James Michael May

James Michael May's AcademicInfluence.com Rankings

James Michael May

Biology

#13464

World Rank

#17009

Historical Rank

Neuroscience

#2337

World Rank

#2401

Historical Rank

biology Degrees

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Biology

James Michael May's Degrees

PhD Neuroscience Stanford University

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James Michael May's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. (2009) (544)
Reduction of Dehydroascorbate to Ascorbate by the Selenoenzyme Thioredoxin Reductase* (1997) (334)
Protection and Recycling of α-Tocopherol in Human Erythrocytes by Intracellular Ascorbic Acid (1998) (294)
How does ascorbic acid prevent endothelial dysfunction? (2000) (276)
Role of vitamin C in the function of the vascular endothelium. (2013) (240)
Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells. (1979) (220)
Is ascorbic acid an antioxidant for the plasma membrane? (1999) (213)
Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate. (1996) (191)
Uptake, recycling, and antioxidant actions of α-lipoic acid in endothelial cells (2002) (184)
Erythrocyte ascorbate recycling: antioxidant effects in blood. (1998) (183)
Reduction of the Ascorbyl Free Radical to Ascorbate by Thioredoxin Reductase* (1998) (182)
The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes. (1979) (179)
The mechanism of the insulin-like effects of ionic zinc. (1982) (153)
Vitamin C transport and its role in the central nervous system. (2012) (150)
The Concise Guide to Pharmacology 2013/14: Overview (2013) (143)
Ascorbic acid recycling enhances the antioxidant reserve of human erythrocytes. (1995) (127)
Inflammation in the vascular bed: importance of vitamin C. (2008) (126)
Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity (2007) (124)
Vitamin C promotes maturation of T-cells. (2013) (117)
Ascorbate function and metabolism in the human erythrocyte. (1998) (116)
Oxidative Stress Is a Mediator of Glucose Toxicity in Insulin-secreting Pancreatic Islet Cell Lines* (2004) (113)
Mitochondrial uptake and recycling of ascorbic acid. (2001) (111)
Coordinate regulation of L-arginine uptake and nitric oxide synthase activity in cultured endothelial cells. (2002) (95)
Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase. (1998) (94)
Vitamin C : Its Functions and Biochemistry in Animals and Plants (2004) (91)
The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C (2011) (91)
Human Erythrocyte Membranes Contain a Cytochrome b561 That May Be Involved in Extracellular Ascorbate Recycling* (2006) (89)
Functional Organization of Mammalian Hexokinase II (1996) (88)
Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. (2004) (88)
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid (2008) (87)
Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice (2009) (83)
Nitrite uptake and metabolism and oxidant stress in human erythrocytes. (2000) (81)
Requirement for GSH in recycling of ascorbic acid in endothelial cells. (2001) (79)
Interaction of ascorbate and alpha-tocopherol in resealed human erythrocyte ghosts. Transmembrane electron transfer and protection from lipid peroxidation. (1996) (79)
Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells. (2002) (77)
Human Erythrocyte Recycling of Ascorbic Acid (2004) (77)
Mechanisms of ascorbic acid recycling in human erythrocytes. (2001) (75)
Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid. (1998) (75)
Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze (2009) (74)
Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease (2017) (73)
Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. (2010) (70)
Characterization of proinsulin-insulin intermediates in human plasma. (1978) (69)
Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells. (2012) (68)
Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis. (2005) (68)
Abnormal Islet and Adipocyte Function in Young B-cell-deficient Rats with Near-Normoglycemia (1984) (67)
Reduction and uptake of methylene blue by human erythrocytes. (2004) (65)
Ascorbate Transport and Recycling by SH-SY5Y Neuroblastoma Cells: Response to Glutamate Toxicity (2006) (62)
Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice (2009) (61)
Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine (2013) (60)
Ascorbate is the major electron donor for a transmembrane oxidoreductase of human erythrocytes. (1995) (59)
Ascorbic acid protects SH-SY5Y neuroblastoma cells from apoptosis and death induced by β-amyloid (2006) (58)
Low ascorbic acid and increased oxidative stress in gulo(−/−) mice during development (2010) (58)
Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs. (2001) (58)
Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice[S] (2014) (56)
Extracellular reduction of the ascorbate free radical by human erythrocytes. (2000) (56)
Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. (2003) (55)
Plant catechols prevent lipid peroxidation in human plasma and erythrocytes (2001) (54)
Ascorbic Acid Uptake and Regulation of Type I Collagen Synthesis in Cultured Vascular Smooth Muscle Cells (2008) (53)
Insulin stimulation of Na+ transport and glucose metabolism in cultured kidney cells. (1982) (52)
Vitamin C distribution and retention in the mouse brain (2010) (52)
Uptake and antioxidant effects of ergothioneine in human erythrocytes. (1999) (51)
Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. (2011) (50)
Behavioral and monoamine changes following severe vitamin C deficiency (2013) (50)
α-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells (2008) (50)
Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. (1999) (49)
Macrophage differentiation increases expression of the ascorbate transporter (SVCT2). (2009) (49)
Recycling of vitamin C from its oxidized forms by human endothelial cells. (2003) (49)
Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting steps. (2001) (45)
Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide. (2005) (45)
Ascorbic acid blunts oxidant stress due to menadione in endothelial cells. (2003) (44)
Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells. (1999) (41)
Generation of oxidant stress in cultured endothelial cells by methylene blue: protective effects of glucose and ascorbic acid. (2003) (41)
GSH is required to recycle ascorbic acid in cultured liver cell lines. (2001) (40)
The Effect of Endogenous Gastric Inhibitory Polypeptide on Glucose-induced Insulin Secretion in Mild Diabetes (1978) (40)
Maturational loss of the vitamin C transporter in erythrocytes. (2007) (40)
Glucose utilization in rat adipocytes. The interaction of transport and metabolism as affected by insulin. (1983) (40)
Mitochondrial recycling of ascorbic acid from dehydroascorbic acid: dependence on the electron transport chain. (2002) (39)
A combined deficiency of vitamins E and C causes severe central nervous system damage in guinea pigs. (2006) (39)
Erythrocyte defenses against hydrogen peroxide: the role of ascorbic acid. (1998) (37)
Ascorbate-dependent electron transfer across the human erythrocyte membrane. (1999) (37)
Role of the C-terminal tail of the GLUT1 glucose transporter in its expression and function in Xenopus laevis oocytes. (1995) (36)
N epsilonB29-(+)-biotinylinsulin and its complexes with avidin. Synthesis and biological activity. (1978) (36)
Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation. (2009) (35)
Development of ascorbate transporters in brain cortical capillary endothelial cells in culture (2008) (35)
Ascorbic acid prevents increased endothelial permeability caused by oxidized low density lipoprotein (2010) (34)
Redox regulation of ascorbic acid transport: Role of transporter and intracellular sulfhydryls (2004) (34)
Vitamin C recycling and function in human monocytic U-937 cells. (1999) (34)
Recycling of the ascorbate free radical by human erythrocyte membranes. (2001) (34)
The simple model of adipocyte hexose transport. Kinetic features, effect of insulin, and network thermodynamic computer simulations. (1982) (33)
Functional Interaction between the N- and C-terminal Halves of Human Hexokinase II* (1999) (33)
Serum angiotensin converting enzyme in diabetic patients. (1993) (33)
Coupled Glucose Transport and Metabolism in Cultured Neuronal Cells: Determination of the Rate-Limiting Step (1995) (33)
Nitric oxide mediates tightening of the endothelial barrier by ascorbic acid. (2011) (32)
Ascorbic acid spares α-tocopherol and decreases lipid peroxidation in neuronal cells (2003) (31)
Ascorbic acid prevents high glucose-induced apoptosis in human brain pericytes. (2014) (31)
Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice (2016) (31)
Combined Vitamin C and Vitamin E Deficiency Worsens Early Atherosclerosis in Apolipoprotein E–Deficient Mice (2010) (30)
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. (2018) (30)
Regulation of embryonic neurotransmitter and tyrosine hydroxylase protein levels by ascorbic acid (2013) (30)
Macrophage IKK&agr; Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis (2016) (29)
Ascorbic acid spares α-tocopherol and prevents lipid peroxidation in cultured H4IIE liver cells (2003) (28)
Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice (2010) (28)
Glucose utilization in islets of hyperglycemic rat models with impaired glucose-induced insulin secretion. (1987) (28)
Uptake and reduction of α-lipoic acid by human erythrocytes (2007) (27)
Inhibition of aldose reductase in human erythrocytes by vitamin C. (1999) (27)
Ascorbate uptake and antioxidant function in peritoneal macrophages. (2005) (26)
Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability (2015) (26)
Mitochondrial recycling of ascorbic acid as a mechanism for regenerating cellular ascorbate (2007) (25)
Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. (2016) (24)
Triacylglycerol turnover in large and small rat adipocytes: effects of lipolytic stimulation, glucose, and insulin. (1982) (24)
Ascorbic acid efflux and re-uptake in endothelial cells: maintenance of intracellular ascorbate (2009) (24)
Selenium spares ascorbate and α‐tocopherol in cultured liver cell lines under oxidant stress (2001) (24)
Selective macrophage ascorbate deficiency suppresses early atherosclerosis. (2011) (23)
Thioredoxin Reductase Reduces Lipid Hydroperoxides and Spares α-Tocopherol (2002) (22)
Ascorbic acid decreases oxidant stress in endothelial cells caused by the nitroxide tempol (2005) (22)
Liposomes Containing α-Tocopherol and Ascorbate are Protected from an External Oxidant Stress (1997) (22)
Potentiation by Glucose of Lipolytic Responsiveness of Human Adipocytes (1986) (21)
Ascorbate-dependent protection of human erythrocytes against oxidant stress generated by extracellular diazobenzene sulfonate. (2000) (21)
Ascorbate reverses high glucose- and RAGE-induced leak of the endothelial permeability barrier. (2014) (21)
Cobalt‐induced oxidant stress in cultured endothelial cells: Prevention by ascorbate in relation to HIF‐1α (2009) (21)
The role of glutathione in rat adipocyte pentose phosphate cycle activity. (1981) (21)
The inhibition of hexose transport by permeant and impermeant sulfhydryl agents in rat adipocytes. (1985) (20)
Increased Expression of SVCT2 in a New Mouse Model Raises Ascorbic Acid in Tissues and Protects against Paraquat-Induced Oxidative Damage in Lung (2012) (20)
Ascorbic acid prevents oxidant-induced increases in endothelial permeability. (2011) (19)
Combined selenium and vitamin C deficiency causes cell death in guinea pig skeletal muscle. (2009) (18)
Ascorbic acid spares alpha-tocopherol and decreases lipid peroxidation in neuronal cells. (2003) (18)
Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice (2018) (18)
Recycling of vitamin C by mammalian thioredoxin reductase. (2002) (18)
Accessibility and reactivity of ascorbate 6-palmitate bound to erythrocyte membranes. (1996) (18)
Oxidized lipoprotein induces the macrophage ascorbate transporter (SVCT2): protection by intracellular ascorbate against oxidant stress and apoptosis. (2009) (17)
Regulation of the human ascorbate transporter SVCT2 exon 1b gene by zinc-finger transcription factors. (2011) (17)
Intracellular Ascorbate Prevents Endothelial Barrier Permeabilization by Thrombin* (2015) (16)
Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism. (2004) (16)
Monitoring conformational change in the human erythrocyte glucose carrier: use of a fluorescent probe attached to an exofacial carrier sulfhydryl. (1993) (16)
Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. (1994) (16)
Ascorbic acid transport in brain microvascular pericytes. (2015) (15)
Localization of a reactive exofacial sulfhydryl on the glucose carrier of human erythrocytes. (1990) (15)
Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton. (2016) (15)
Reaction of an exofacial sulfhydryl group on the erythrocyte hexose carrier with an impermeant maleimide. Relevance to the mechanism of hexose transport. (1988) (15)
Control of glucose phosphorylation in L6 myotubes by compartmentalization, hexokinase, and glucose transport. (2003) (14)
Ascorbic acid spares alpha-tocopherol and prevents lipid peroxidation in cultured H4IIE liver cells. (2003) (13)
Nitric oxide-induced oxidant stress in endothelial cells: amelioration by ascorbic acid. (2004) (13)
CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a. (2011) (13)
Ascorbic acid repletion: A possible therapy for diabetic macular edema? (2016) (13)
Thiol‐fatty acylation of the glucose transport protein of human erythrocytes (1990) (13)
Nitrite Generates an Oxidant Stress and Increases Nitric Oxide in EA.hy926 Endothelial Cells (2004) (12)
Location and recycling of mitochondrial α-tocopherol (2003) (12)
Inhibition of hexose transport and labelling of the hexose carrier in human erythrocytes by an impermeant maleimide derivative of maltose. (1988) (12)
Determinants of gastric inhibitory polypeptide and insulin secretion. (1981) (12)
Coupling of glucose transport and phosphorylation in Xenopus oocytes and cultured cells: Determination of the rate‐limiting step (1993) (11)
Oxidized LDL up-regulates the ascorbic acid transporter SVCT2 in endothelial cells (2010) (11)
Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity. (2006) (11)
Uptake and reduction of alpha-lipoic acid by human erythrocytes. (2007) (11)
Catalase-dependent measurement of H2O2 in intact mitochondria. (2002) (11)
Interaction of a permeant maleimide derivative of cysteine with the erythrocyte glucose carrier. Differential labelling of an exofacial carrier thiol group and its role in the transport mechanism. (1989) (11)
Labeling of human erythrocyte band 3 with maltosylisothiocyanate. Interaction with the anion transporter. (1987) (11)
Inhibition of hexose transport by adenosine derivatives in human erythrocytes (1988) (11)
A "cysteineless" GLUT1 glucose transporter has normal function when expressed in Xenopus oocytes. (1995) (10)
Selective labeling of the erythrocyte hexose carrier with a maleimide derivative of glucosamine: relationship of an exofacial sulfhydryl to carrier conformation and structure. (1989) (10)
Ascorbic acid catabolism: breakdown pathways in animals and plants (2004) (10)
Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice (2019) (10)
Interaction of the Transcription Start Site Core Region and Transcription Factor YY1 Determine Ascorbate Transporter SVCT2 Exon 1a Promoter Activity (2012) (9)
Differential labeling of the erythrocyte hexose carrier by N-ethylmaleimide: correlation of transport inhibition with reactive carrier sulfhydryl groups. (1989) (9)
Chelation of intracellular iron enhances endothelial barrier function: a role for vitamin C? (2010) (9)
Similarities in the metabolism of alloxan and dehydroascorbate in human erythrocytes. (1998) (8)
Ascorbic acid efflux from human brain microvascular pericytes: role of re-uptake. (2015) (8)
Thioredoxin reductase reduces lipid hydroperoxides and spares alpha-tocopherol. (2002) (8)
Ligand-induced conformational changes modify proteolytic cleavage of the adipocyte insulin-sensitive glucose transporter. (1993) (7)
Photolabeling of the human erythrocyte glucose carrier with androgenic steroids. (1988) (7)
Photoaffinity labeling of glyceraldehyde-3-phosphate dehydrogenase by an aryl azide derivative of glucosamine in human erythrocytes. (1986) (7)
Combined vitamin C and E deficiency induces motor defects in gulo−/−/SVCT2+/− mice (2013) (7)
Troglitazone protects human erythrocytes from oxidant damage. (2000) (7)
Abstract 15960: Macrophage IKKalpha Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival and Decreases Early Atherosclerosis (2013) (6)
Human Erythrocyte Recycling of Ascorbic Acid: Relative Contributions from the Ascorbate Free Radical and Dehydroascorbic Acid (2004) (5)
Testing models of insulin binding in rat adipocytes using network thermodynamic computer simulations. (1986) (5)
Rat adipocyte utilization of different substrates: Effects of cell size and the control of lipogenesis (1982) (5)
Liposomes containing alpha-tocopherol and ascorbate are protected from an external oxidant stress. (1997) (5)
Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. (2012) (5)
Tryptic digestion of the human erythrocyte glucose transporter: effects on ligand binding and tryptophan fluorescence. (1993) (5)
Location and recycling of mitochondrial alpha-tocopherol. (2003) (5)
In vitro phosphorylation of a synthetic collagen peptide by cyclic AMP-dependent protein kinase. (1984) (4)
The inhibition of hexose transport and metabolism by small amounts of adenosine 5'-triphosphate in isolated rat adipocytes. (1982) (4)
Selenium spares ascorbate and alpha-tocopherol in cultured liver cell lines under oxidant stress. (2001) (4)
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice (2021) (3)
Interaction of Ascorbate and -Tocopherol in Resealed Human Erythrocyte Ghosts (1996) (3)
Effects of ATP depletion on the mechanism of hexose transport in intact human erythrocytes (1988) (3)
Assessing the reductive capacity of cells by measuring the recycling of ascorbic and lipoic acids. (2010) (3)
The effect of insulin-stimulated pentose phosphate cycle activity on cellular glutathione content in rat adipocytes. (1982) (3)
Sodium‐dependent vitamin C transporter‐2 mediates vitamin C transport at the cortical nerve terminal (2015) (3)
The one-site model of human erythrocyte glucose transport: testing its predictions using network thermodynamic computer simulations. (1991) (2)
Ascorbic acid in the central nervous system: uptake, distribution and functions (2004) (2)
Dietary allowances for vitamin C: Recommended Dietary Allowances and optimal nutrient ingestion (2004) (2)
Photolabeling of the adipocyte hexose carrier with an aryl azide derivative of maltose (1987) (2)
Famine From Feast: Low Red Cell Vitamin C Levels in Diabetes☆ (2015) (2)
Medical aspects of the development of scurvy: past and present (2013) (2)
Correction: Increased Expression of SVCT2 in a New Mouse Model Raises Ascorbic Acid in Tissues and Protects against Paraquat-Induced Oxidative Damage in Lung (2012) (1)
Inhibition of hexose transport in the human erythrocyte by 5, 5′-dithiobis(2-nitrobenzoic acid): Role of an exofacial carrier sulfhydryl group (1989) (1)
Interactions of selenium, vitamin E, and vitamin C in atherosclerosis (2002) (1)
The insulin-like effects of low molecular weight thiols: role of trace metal contamination of commercial thiols. (1980) (1)
Abnormal total NADP+ and glutathione and impaired glucose metabolism of large rat adipocytes (1980) (1)
The expression of biologically active recombinant ricin A chain "in vitro" (1988) (0)
Abstract 549: Loss of Macrophage Akt2/Akt3 or Akt1/Akt2 Decreases Cell Survival and Suppresses Early Atherosclerosis in Ldlr Null Mice (2015) (0)
SLC23 family of ascorbic acid transporters in GtoPdb v.2021.3 (2021) (0)
skeletal muscle cells: rate-limiting steps Glucose uptake and metabolism by cultured human (2016) (0)
Is ascorbic acid an antioxidant for the plasma membrane? (2020) (0)
Microsoft Word-Manuscript_Track Changes.docx (2015) (0)
Erratum (2013) (0)
Abstract 15417: Macrophage Deficiency of Akt2 or Both Akt1 and Akt2 Reduces Atherosclerosis: Akt is Critical for Macrophage Polarization and Survival (2013) (0)
SLC23 family of ascorbic acid transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
N EB2g-( +)-Biotinylinsulin and Its Complexes with Avidin (2011) (0)
Role of short-term α-lipoic acid therapy in patients with hypercholesterolemia to reverse oxidative stress and endothelial dysfunction (2015) (0)
Ingestive Behavior and Neurosciences A Combined Deficiency of Vitamins E and C Causes Severe Central Nervous System Damage in Guinea Pigs 1 , 2 (2006) (0)
Abstract 2: Loss of Rictor in Macrophages Suppresses Their Viability and Reduces Atherosclerosis in LDLR Null Mice (2016) (0)
Abstract 129: Overexpression of P110alpha Induces Vascular Malformation in Mouse Tail, Feet and Ears (2016) (0)
Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability (2015) (0)

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