John M. Pawelek
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John M. Pawelekbiology Degrees
Biology
#11836
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#15263
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Molecular Biology
#1867
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#1896
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Biochemistry
#1980
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#2121
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Chemistry Biology
John M. Pawelek's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is John M. Pawelek Influential?
(Suggest an Edit or Addition)John M. Pawelek's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin. (1982) (524)
- Tumor-targeted Salmonella as a novel anticancer vector. (1997) (504)
- Lipid A mutant Salmonella with suppressed virulence and TNFα induction retain tumor-targeting in vivo (1999) (428)
- Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. (2014) (352)
- L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions (2012) (342)
- Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. (1996) (328)
- Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis (2008) (312)
- Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome (2011) (261)
- Bacteria as tumour-targeting vectors. (2003) (258)
- Biodistribution and genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of Salmonella typhimurium. (2000) (256)
- New regulators of melanin biosynthesis and the autodestruction of melanoma cells (1980) (222)
- Factors regulating growth and pigmentation of melanoma cells. (1976) (221)
- Curcumin: A new candidate for melanoma therapy? (2016) (218)
- 5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity (1978) (184)
- Dopachrome conversion: a possible control point in melanin biosynthesis. (1980) (166)
- Biology of hypopigmentation. (1988) (163)
- The cancer cell--leukocyte fusion theory of metastasis. (2008) (160)
- Control of phenotypic expression of cultured melanoma cells by melanocyte stimulating hormones. (1973) (157)
- Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa. (1988) (151)
- Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells (1975) (149)
- Tumour-cell fusion as a source of myeloid traits in cancer. (2005) (143)
- High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. (1994) (131)
- Animals under the sun: effects of ultraviolet radiation on mammalian skin. (1998) (129)
- Autophagy in cutaneous malignant melanoma (2010) (125)
- Melanoma × macrophage hybrids with enhanced metastatic potential (1998) (124)
- UVB-induced melanogenesis may be mediated through the MSH-receptor system. (1989) (124)
- Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for alpha MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes. (1995) (114)
- Regulation of melanocyte stimulating hormone action at the receptor level: discontinuous binding of hormone to synchronized mouse melanoma cells during the cell cycle. (1974) (114)
- Molecular biology of pigment cells. Molecular controls in mammalian pigmentation. (1973) (112)
- Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT–tumor hybrids by FISH (2005) (108)
- Effects of thyroxine and low oxygen tension on chondrogenic expression in cell culture. (1969) (107)
- β1,6-Branched Oligosaccharides Are Increased in Lymph Node Metastases and Predict Poor Outcome in Breast Carcinoma (2005) (106)
- Molecular cascades in UV-induced melanogenesis: a central role for melanotropins? (1992) (105)
- A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer (2013) (104)
- A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. (2000) (103)
- Response of mouse melanoma cells to melanocyte stimulating hormone (1974) (100)
- Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient (2004) (94)
- Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein. (1996) (92)
- Tumour cell hybridization and metastasis revisited (2000) (90)
- UV Light and MSH Receptors (1999) (86)
- Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines. (1990) (81)
- Dopachrome conversion factor functions as an isomerase. (1990) (81)
- Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents. (2016) (79)
- Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes (1996) (77)
- Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans. (2004) (74)
- Fusion hybrids with macrophage and melanoma cells up-regulate N-acetylglucosaminyltransferase V, beta1-6 branching, and metastasis. (2001) (73)
- Synthesis and characterization of melanins from dihydroxyindole-2-carboxylic acid and dihydroxyindole. (1992) (72)
- New regulators of melanogenesis are associated with purified tyrosinase isozymes. (1982) (72)
- Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system (1977) (71)
- The biosynthesis of mammalian melanin. (1982) (70)
- Beta1,6-branched oligosaccharides and coarse vesicles: a common, pervasive phenotype in melanoma and other human cancers. (2003) (64)
- Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone. (1975) (62)
- Antitumour effects of genetically engineered Salmonella in combination with radiation. (2000) (60)
- MSH receptors in immortalized human epidermal keratinocytes: A potential mechanism for coordinate regulation of the epidermal‐melanin unit (1993) (60)
- Melanoma cells which require cyclic AMP for growth (1975) (59)
- Why do melanomas get so dark? (2009) (58)
- Construction of VNP20009 (2004) (58)
- Demonstration of tyrosinase in the adult bovine uveal tract and retinal pigment epithelium. (1978) (57)
- Structural/functional relationships between internal and external MSH receptors: Modulation of expression in Cloudman melanoma cells by UVB radiation (1991) (57)
- Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis. (1999) (55)
- Tumor-Targeted Salmonella (2002) (54)
- After dopachrome? (1991) (52)
- Evidence suggesting that a cyclic AMP‐dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells (1979) (50)
- Melanoma cells. (1979) (50)
- Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? (2006) (49)
- Salmonella pathogenicity island-2 and anticancer activity in mice (2002) (48)
- Human monocyte x mouse melanoma fusion hybrids express human gene. (2001) (48)
- Cancer-cell fusion with migratory bone-marrow-derived cells as an explanation for metastasis: new therapeutic paradigms. (2008) (44)
- L-Tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells (1989) (42)
- A Melanoma Lymph Node Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: A Second Case of Leucocyte-Tumor Cell Hybridization in Cancer Metastasis (2017) (42)
- What controls melanogenesis? (1998) (41)
- GnT-V, macrophage and cancer metastasis: A common link (2004) (41)
- Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells. (1999) (39)
- Increase in melanin formation and promotion of cytotoxicity in cultured melanoma cells caused by phosphorylated isomers of L-dopa. (1986) (38)
- Tumor-targeted Salmonella. Highly selective delivery vectors. (2000) (37)
- Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis (2020) (37)
- Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha. (1998) (36)
- Internal binding sites for MSH: Analyses in wild‐type and variant Cloudman melanoma cells (1990) (36)
- Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells. (1991) (35)
- Receptors for B-melanocyte-stimulating hormone exhibit positive cooperativity in synchronized melanoma cells. (1988) (35)
- Phosphorylated isomers of L-dopa stimulate MSH binding capacity and responsiveness to MSH in cultured melanoma cells. (1987) (35)
- Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers. (1990) (34)
- Coexpression of β1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome (2005) (34)
- Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line (1984) (33)
- Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine (1995) (33)
- Altered N-glycosylation in macrophage x melanoma fusion hybrids. (1999) (33)
- Evidence that dopachrome tautomerase is a ferrous iron‐binding glycoprotein (1992) (33)
- Genetic control of melanization: isolation and analysis of amelanotic variants from cultured melanotic melanoma cells. (1974) (32)
- Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer (2014) (32)
- Inhibition of proliferation of cloudman S91 melanoma cells by insulin and characterization of some insulin‐resistant variants (1980) (31)
- Melanoma x macrophage fusion hybrids acquire increased melanogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism. (1998) (29)
- Leukocyte-cancer cell fusion: initiator of the warburg effect in malignancy? (2011) (29)
- Small Gtpase rab3A is associated with melanosomes in melanoma cells. (2000) (29)
- Stimulation of the receptor for melanocyte‐stimulating hormone by retinoic acid (1990) (26)
- Up-regulation of MSH receptors by MSH in Cloudman melanoma cells. (1992) (26)
- GnT-V expression and metastatic phenotypes in macrophage-melanoma fusion hybrids is down-regulated by 5-Aza-dC: evidence for methylation sensitive, extragenic regulation of GnT-V transcription. (2006) (26)
- Melanophages reside in hypermelanotic, aberrantly glycosylated tumor areas and predict improved outcome in primary cutaneous malignant melanoma (2007) (25)
- MSH binding in bomirski amelanotic hamster melanoma cells is stimulated by L-tyrosine (1987) (23)
- Hairless pigmented guinea pigs: a new model for the study of mammalian pigmentation. (1990) (23)
- &bgr;1,6-branched oligosaccharides regulate melanin content and motility in macrophage–melanoma fusion hybrids (2007) (22)
- Expression of c-Met proto-oncogene in metastatic macrophage x melanoma fusion hybrids: implication of its possible role in MSH-induced motility. (2003) (22)
- Co‐localization of β1,6‐branched Oligosaccharides and Coarse Melanin in Macrophage–Melanoma Fusion Hybrids and Human Melanoma Cells In Vitro (2004) (21)
- Viewing Malignant Melanoma Cells as Macrophage-tumor Hybrids (2007) (21)
- Effects of ultraviolet irradiation on the cell cycle. (1994) (20)
- [51] Melanoma cells (1979) (19)
- Tumour-Selective Salmonella-Based Cancer Therapy (2001) (19)
- New regulatory factors for melanogenesis: developmental changes in neonatal mice of various genotypes. (1983) (19)
- Leukocyte–Cancer Cell Fusion—Genesis of a Deadly Journey (2019) (18)
- A metabolic switch to memory CAR T cells: Implications for cancer treatment. (2020) (17)
- Tumor-targeted salmonella as a novel anti-melanoma vector: 491 (1997) (17)
- THE DEVELOPMENT OF HOUSEHOLD WASTEWATER TREATMENT PLANTS IN POLAND - ADVANTAGES AND DISADVANTAGES (2017) (17)
- Clinical evaluation of the lightening effect of cytidine on hyperpigmented skin (2018) (16)
- Studies on the Cloudman melanoma cell line as a model for the action of MSH. (1985) (16)
- Assay of melanotropic peptides in an in vitro mammalian system. (1981) (14)
- Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential. (1999) (14)
- Pmel17: controversial indeed but critical to melanocyte function. (2006) (14)
- Upregulation of alpha and beta integrin subunits in metastatic macrophage–melanoma fusion hybrids (2009) (14)
- A possible role for melanin precursors in regulating both pigmentation and proliferation of melanocytes. (1988) (13)
- Recent Advances in Studies of Skin Color and Skin Cancer (2020) (12)
- Phosphorylated mixed isomers of L-dopa increase melanin content in skins of Skh-2 pigmented hairless mice. (1987) (12)
- Evidence for glycosylation as a regulator of the pigmentary system: key roles of sialyl(α2-6)gal/GalNAc-terminated glycans in melanin synthesis and transfer (2015) (11)
- Quantitative and economical aspects of water loss in water-pipe networks in rural areas (2008) (10)
- Phenylalanine hydroxylase in melanoma cells (1978) (10)
- Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene. (2000) (9)
- Evidence that a 90-kDa phosphoprotein, an associated kinase, and a specific phosphatase are involved in the regulation of Cloudman melanoma cell proliferation by insulin. (1985) (9)
- Approaches to increasing skin melanin with MSH analogs and synthetic melanins. (2001) (9)
- Chimeric antigen receptor T-cell therapy for melanoma (2021) (8)
- Melanoma as a macrophage/melanocyte hybrid and the symbiotic nature of eukaryotic cells. (1993) (8)
- A melanoma patient with macrophage-cancer cell hybrids in the primary tumor, a lymph node metastasis and a brain metastasis. (2021) (8)
- Cytidine decreases melanin content in a reconstituted three-dimensional human epidermal model (2019) (8)
- Is human melanogenesis stimulated by cyclic AMP? (1990) (7)
- A new enzyme in the pigment pathway? (1985) (7)
- Water Management in Poland in View of Water Supply and Sewage Disposal Infrastructure Development (2015) (7)
- LB1591 In-vitro and in-vivo evaluation of skin lightening efficacy of cytidine (2018) (6)
- Positive regulation of melanogenesis by l-tyrosine and l-dopa (1987) (6)
- Interactions between insulin and the cyclic AMP system of Cloudman S91 mouse melanoma cells (1983) (6)
- Control of cultured melanoma cells by melanocyte stimulating hormone. Abstr. (1972) (5)
- Membrane glycoproteins common to vesicles and melanosomes in mouse melanoma cells. (2008) (5)
- Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella. (2016) (4)
- Human Cancer Biology Punctate LC 3 B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation , Metastasis , and Poor Outcome (2012) (4)
- Variation in water consumption in rural households during the multi-year period (2016) (4)
- Ultraviolet light and pigmentation of the skin (1992) (4)
- Co-localization of beta1,6-branched oligosaccharides and coarse melanin in macrophage-melanoma fusion hybrids and human melanoma cells in vitro. (2004) (4)
- Transmission of Information in Neoplasia by Extracellular Vesicles (2015) (4)
- Defect of insulin receptor in insulin‐resistant variants of Cloudman S91 mouse melanoma cells (1992) (3)
- Analysis of the sewage system expandability in Mściwojów commune (2013) (3)
- International Scientific Collaboration Is Needed to Bridge Science to Society: USERN2020 Consensus Statement (2021) (3)
- Prediction of the Stability of Chemical Composition of Therapeutic Groundwater (2019) (3)
- Erratum to “Human monocyte X mouse melanoma fusion hybrids express human gene” [Gene 275 (2001) 103–106] (2002) (2)
- The Interdependence of Organic and Biogenic Pollutants Concentrations in the Aspect of their Susceptibility to Biodegradation – A Case Study (2021) (2)
- Genetic evidence for tumor-hematopoietic cell hybrids in a human renal cell carcinoma metastasis (2004) (2)
- Abstract 3786: LC3B-positive autophagosomes are a common feature of solid tumors and associated with proliferation, metastasis and poor outcome (2011) (1)
- Abstract 1477: Tumor cell-leukocyte fusion in human cancer: A melanoma brain metastasis with a donor-patient hybrid genome following allogeneic BMT (2011) (1)
- Selected quality indictators for water drawn from a retention reservoir (2008) (1)
- Development of water supply and sewage systems in rural areas of Małopolskie and Podkarpackie Voivodeships (2014) (1)
- Evidence for glycosylation as a regulator of the pigmentary system: key roles of sialyl(α2-6)gal/GalNAc-terminated glycans in melanin synthesis and transfer (2015) (1)
- Ozone water treatment in small water purification plants in Poland – Mszana Dolna case study (2019) (1)
- Investigation of the Wastewater Treatment Plant Processes Efficiency Using Statistical Tools (2020) (1)
- is a ferrous iron-binding (1992) (1)
- Growth by Melanocyte (2016) (0)
- Ultraviolet light, MSH receptors, and the melanocyte cell cycle: 241 (1993) (0)
- AN UNEXPECTED ROLE FOR TYROSINASE IN MELANIN BIOSYNTHESIS AND THE AUTODESTRUCTION OF MELANOMA CELLS (1982) (0)
- Melanoma/macrophage hybrids as models for melanoma metastasis: 189 (1997) (0)
- studies with normal human melanocytes and melanoma cell lines isolated from primary and metastatic tumors and clinical melanoma metastases revealed that thymosin b4 is specifically up-regulated in metastatic human melano- (2006) (0)
- Melanoma pigmentation and progression: Some things new under the sun. (2004) (0)
- Is human melanogenesis stimulated by cyclic AMP? Commentary and authors' reply (1990) (0)
- Isolation and analysis of melanoma cells resistant to msh-mediated growth controls. Abstr. (1974) (0)
- Melanotropin Mechanisms of Action: Melanogenesis (2018) (0)
- Tricarboxylic acid esters : with inhibitory effect on lipid peroxidation (1992) (0)
- Cancer Cell Fusion with Myeloid Cells: Implications for Energy Metabolism in Malignant Hybrids (2011) (0)
- Synthesis of 125I-Labeled β-Melanotropin and Assay of Melanotropin Receptors (1991) (0)
- A GENETICALLY DEFINED ROLE FOR PROTEIN PHOSPHORYLATION IN THE REGULATION OF PROLIFERATION BY INSULIN (1982) (0)
- GnT-V regulates motility and melanogenesis in macrophage???melanoma fusion hybrids (2006) (0)
- Aberrant Glycosylation and its Correlation with Expression of GNTV and Matriptase in Malignant Melanoma (2008) (0)
- Nest-specific Golgi complex abnormalities in cutaneous malignant melanoma (2006) (0)
- Phosphorylated derivatives of L-dopa and compositions of phosphorylated derivatives of L-dopa and compositions. (1990) (0)
- The effects of insulin on cloudman s91 melanoma cells. Abstr. (1980) (0)
- Alteration in number and affinity of insulin receptors on insulin-resistant cloudman melanoma cells. Abstr. (1983) (0)
- Bordetella pertussis exhibits specific attachment, invasion, and cytotoxic capabilities toward human cancer cells. (2004) (0)
- Leucocyte-Tumor Cell Hybridization Can Initiate Cancer Metastasis (2020) (0)
- Using of water from a mountain stream for water supply purposes (1999) (0)
- [Effect of Inhitrypsin preparation on transplantability of polyoma tumor cells in CBA mice]. (1979) (0)
- Water supply network expansion in the commune of Mściwojów as relates to the pilot project vital landscapes (2013) (0)
- Variation in water consumption on the farms of Goszcza village connected to Kocmyrzow-Luborzyca water supply system (2001) (0)
- Aberrant glycosylation in cutaneous malignant melanoma: multilevel regulation of GnT-V expression (2006) (0)
- Genetic Control of Melanization: Isolation from Cultured Melanotic Melanoma Cells (amelanotic melanoma variants/cell culture/mutagenesi (2016) (0)
- Demonstration and characterization of polyoma-tumor-associated antigenic components using preparative and analytical polyacrylamide gel electrophoresis. (1982) (0)
- A Canadian experiment with breast cancer information exchange pilot projects. (1996) (0)
- Vesicular membrane glycoproteins and melanosomal biogenesis (1991) (0)
- Is dopachrome tautomerase necessary to get DHICA from dopachrome? (1994) (0)
- DHICA conversion: a possible control point in melanin biosynthesis (1993) (0)
- The frequency and duration of increased turbidity levels of montane stream water (2000) (0)
- Abstract 5106: Autophagy in malignant melanoma and breast carcinoma (2010) (0)
- Matriptase and gnt-v localized to beta 1,6-branched oligosaccharide-rich regions in japanese melanomas. (2004) (0)
- [Comparison of soluble surface proteins of embryonic cells and of cells of mice polyoma tumor CBA/T-6T-6]. (1977) (0)
- Reply to the response to our letter (2006) (0)
- Evidence that a 90-kDa phosphoprc specific phosphatase are involved i) melanoma cell proliferation by insu (2016) (0)
- Variants from cultured melanotic melanoma cells. (1974) (0)
- Restricting Tumor Lactate Metabolism using Dichloroacetate Improves T Cell Functions (2021) (0)
- L-DOPA AND COMPOSITIONS AND METHODS FOR INCREASING THE MELANN CONTENT IN MAMMALAN SKIN AND HAIR (2017) (0)
- [Polyoma tumor growth in hamsters immunized with surface protein extracts from cells of a trypsinized tumor]. (1977) (0)
- Vincent J. Hearing, PhD (2010) (0)
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What Schools Are Affiliated With John M. Pawelek?
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