James N. Ihle

Q: What Schools Are Affiliated With James N. Ihle

James N. Ihle is affiliated with the following schools: Yale University, University of Arizona, Medical University of South Carolina, University of Tennessee, University of Chicago, University of Washington, Osaka University, University of Tennessee Health Science Center, Erasmus University Rotterdam

James N. Ihle's AcademicInfluence.com Rankings

James N. Ihle

Biology

#4393

World Rank

#6556

Historical Rank

Molecular Biology

#338

World Rank

#344

Historical Rank

Neuroscience

#461

World Rank

#480

Historical Rank

Biochemistry

#453

World Rank

#534

Historical Rank

biology Degrees

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Biology

James N. Ihle's Degrees

PhD Biochemistry University of California, San Diego
Bachelors Chemistry University of California, San Diego

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James N. Ihle's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

STATs: Signal Transducers and Activators of Transcription (1996) (1520)
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene (1996) (1459)
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses (1998) (1368)
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells (1996) (1242)
Cytokine receptor signalling (1995) (1204)
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin (1993) (1163)
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors (1998) (1112)
Gene-marking to trace origin of relapse after autologous bone-marrow transplantation (1993) (971)
Jaks and Stats in signaling by the cytokine receptor superfamily. (1995) (935)
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase (1993) (929)
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. (2003) (888)
Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. (1987) (836)
The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop (1999) (785)
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene (1993) (777)
The Stat family in cytokine signaling. (2001) (737)
Defective Lymphoid Development in Mice Lacking Jak3 (1995) (687)
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction (1993) (667)
Signaling by the cytokine receptor superfamily: JAKs and STATs. (1994) (650)
Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity. (1983) (640)
Signaling through the hematopoietic cytokine receptors. (1995) (633)
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. (1999) (616)
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells (1994) (615)
SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality (1999) (572)
Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. (1991) (529)
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway (1993) (513)
Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. (2000) (509)
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region (1994) (507)
SOCS3 regulates the plasticity of gp130 signaling (2003) (465)
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. (2002) (455)
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. (1993) (452)
Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients (1993) (435)
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. (2000) (408)
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines (1988) (407)
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex (2002) (397)
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis (1999) (391)
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis (1993) (374)
Procedures for the purification of interleukin 3 to homogeneity. (1982) (374)
Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan. (1984) (366)
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop (1997) (362)
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. (2000) (341)
B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells (1987) (340)
Interferon-induced nuclear signalling by Jak protein tyrosine kinases (1993) (335)
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13 (1992) (333)
Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4 (1997) (321)
Contenders in FasL/TNF death signaling (1995) (320)
Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production1 (2001) (311)
Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells. (1994) (307)
Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26. (1992) (302)
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. (1994) (299)
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism (1985) (292)
Naturally occurring dominant negative variants of Stat5 (1996) (285)
Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response (1996) (284)
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. (1994) (277)
Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. (1988) (271)
Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand (1993) (270)
Stat5 tetramer formation is associated with leukemogenesis. (2005) (245)
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation (1994) (239)
Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants. (1994) (233)
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses (1997) (228)
Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine. (1981) (222)
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. (2000) (221)
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation (2003) (217)
The Janus protein tyrosine kinase family and its role in cytokine signaling. (1995) (214)
Kinase‐negative mutants of JAK1 can sustain interferon‐gamma‐inducible gene expression but not an antiviral state. (1996) (213)
Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line. (1982) (212)
Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors (1988) (212)
Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. (1999) (201)
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. (2000) (200)
Distribution of the mammalian Stat gene family in mouse chromosomes. (1995) (199)
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons (2008) (191)
Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation (2009) (190)
Permissive role of interleukin 3 (IL‐3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture (1985) (183)
Interaction between the Components of the Interferon γ Receptor Complex (*) (1995) (182)
Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor. (1988) (178)
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. (2002) (171)
Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development (2004) (163)
Regulation of interleukin 7–dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5 (2005) (162)
The Evil proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development (1997) (162)
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus (1991) (154)
Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line. (1986) (153)
Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations. (1994) (153)
Jak2: normal function and role in hematopoietic disorders. (2007) (152)
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. (2004) (152)
Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells (1994) (151)
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes (1985) (151)
Re-examination of the Role of Suppressor of Cytokine Signaling 1 (SOCS1) in the Regulation of Toll-like Receptor Signaling*♦ (2004) (150)
Interleukin 3: Possible Roles in the Regulation of Lymphocyte Differentiation and Growth (1982) (149)
Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer (1998) (148)
Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. (1993) (141)
Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases (*) (1995) (139)
Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes. (1982) (136)
A small amphipathic α‐helical region is required for transcriptional activities and proteasome‐dependent turnover of the tyrosine‐phosphorylated Stat5 (2000) (135)
Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA (1993) (134)
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. (2005) (133)
Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor (1992) (131)
Signaling by the Cytokine Receptor Superfamily a (1998) (131)
Absence of Erythrogenesis and Vasculogenesis in Plcg1-deficient Mice* (2002) (130)
Evidence for specific receptors for interleukin 3 on lymphokine-dependent cell lines established from long-term bone marrow cultures. (1984) (129)
Functional interaction of STAT5 and nuclear receptor co‐repressor SMRT: implications in negative regulation of STAT5‐dependent transcription (2001) (129)
Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6. (1998) (128)
The distal region and receptor tyrosines of the Epo receptor are non‐essential for in vivo erythropoiesis (2001) (127)
Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. (1993) (127)
Phenotypic characteristics of cell lines requiring interleukin 3 for growth. (1982) (127)
Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. (1994) (126)
Chromatin condensation via the condensin II complex is required for peripheral T‐cell quiescence (2011) (126)
Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages (1993) (123)
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53‐regulated apoptosis (2002) (122)
Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. (1990) (120)
Jaks and stats in cytokine signaling (1997) (120)
AUTOGENOUS IMMUNITY TO ENDOGENOUS RNA TUMOR VIRUS : RADIOIMMUNE PRECIPITATION ASSAY OF MOUSE SERUM ANTIBODY LEVELS (1973) (119)
Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. (1987) (116)
Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. (1998) (115)
v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. (1994) (115)
Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor. (1997) (112)
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding (1994) (109)
Divergent Mechanisms Utilized by SOCS3 to Mediate Interleukin-10 Inhibition of Tumor Necrosis Factor α and Nitric Oxide Production by Macrophages* (2006) (109)
Localization of Evi-2 to chromosome 11: linkage to other proto-oncogene and growth factor loci using interspecific backcross mice. (1988) (107)
Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. (1998) (107)
Interleukin-3 and hematopoiesis. (1992) (101)
An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer. (1992) (101)
Establishment of continuous cultures of Thy1.2+, Lytl+,2−T cells with purified interleukin 3 (1981) (101)
Multiple hematopoietic growth factors signal through tyrosine phosphorylation. (1990) (99)
Pharmacokinetics of subcutaneous recombinant human granulocyte colony-stimulating factor in children. (1992) (98)
Correlation of cell-surface phenotype with the establishment of interleukin 3-dependent cell lines from wild-mouse murine leukemia virus-induced neoplasms. (1985) (96)
Immunological regulation of hematopoietic/lymphoid stem cell differentiation by interleukin 3. (1986) (95)
Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter (1991) (95)
The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG. (1994) (92)
DNA rearrangements proximal to the EVI1 locus associated with the 3q21q26 syndrome. (1994) (90)
Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates. (1988) (89)
Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts. (1990) (87)
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2 (2006) (86)
Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity (2007) (86)
STATs and MAPKs: obligate or opportunistic partners in signaling. (1996) (85)
Induction in vivo and in vitro of terminal deoxynucleotidyl transferase by thymosin in bone marrow cells from athymic mice (1978) (82)
AUTOGENOUS IMMUNITY TO ENDOGENOUS RNA TUMOR VIRUS (1974) (81)
Interleukin 3-dependent hematopoietic progenitor cell lines. (1983) (81)
The Challenges of Translating Knockout Phenotypes into Gene Function (2000) (80)
The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1. (1987) (79)
Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors. (1994) (76)
Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development (2001) (75)
Signaling by the cytokine receptor superfamily in normal and transformed hematopoietic cells. (1996) (75)
The Janus protein tyrosine kinases in hematopoietic cytokine signaling. (1995) (75)
Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus. (1978) (75)
Janus kinases in cytokine signalling. (1996) (74)
Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. (1991) (73)
Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. (1975) (72)
Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene (1990) (71)
Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera. (1975) (69)
Chronic immune stimulation is required for Moloney leukaemia virus-induced lymphomas (1981) (68)
Radiation leukemia in C57BL/6 mice. II. Lack of ecotropic virus expression in the majority of lymphomas (1976) (67)
Role of myc in the abrogation of IL3 dependence of myeloid FDC-P1 cells. (1987) (67)
Identification, cDNA Cloning, and Targeted Deletion of p70, a Novel, Ubiquitously Expressed SH3 Domain-Containing Protein (2002) (67)
The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11 (1997) (62)
Radiation leukemia in C57BL/6 mice. I. Lack of serological evidence for the role of endogenous ecotropic viruses in pathogenesis (1976) (60)
Jak1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor (1997) (59)
Recombinant murine granulocyte‐macrophage (GM) colony‐stimulating factor supports formation of GM and multipotential blast cell colonies in culture: Comparison with the effects of interleukin‐3 (1987) (59)
Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene. (1989) (57)
Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses. (1978) (57)
Two Domains of the Erythropoietin Receptor Are Sufficient for Jak2 Binding/Activation and Function (2006) (57)
Purification and serological characterization of the major envelope glycoprotein from AKR murine leukemia virus and its reactivity with autogenous immune sera from mice (1976) (56)
Biological and serological characterization of radiation leukemia virus. (1976) (56)
Feline lymphomas: immunological and cytochemical characterization. (1989) (56)
A Kinase-deficient Splice Variant of the Human JAK3 Is Expressed in Hematopoietic and Epithelial Cancer Cells (*) (1995) (55)
EVI-1 zinc finger protein works as a transcriptional activator via binding to a consensus sequence of GACAAGATAAGATAAN1-28 CTCATCTTC. (1995) (55)
Retrovirus-mediated gene transfer as an approach to analyze neuroblastoma relapse after autologous bone marrow transplantation. (1992) (54)
The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes. (1990) (54)
Physicochemical, biological and serological properties of a leukemogenic virus isolated from cultured RadLV-induced lymphomas of C57BL/Ka mice. (1978) (54)
Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. (1978) (53)
Disposition of recombinant human granulocyte colony-stimulating factor in children with severe chronic neutropenia. (1993) (53)
Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5. (1979) (52)
Hematopoietic Signaling by the Cytokine Receptor Superfamily (1995) (52)
Bipotential murine hemopoietic cell line (NFS-60) that is responsive to IL-3, GM-CSF, G-CSF, and erythropoietin. (1988) (52)
Determination of the transphosphorylation sites of Jak2 kinase. (2004) (52)
Interleukin 3 (1985) (51)
Properties of mouse leukemia viruses. XVI. Suppression of spontaneous fetal leukemias in AKR mice by treatment with broadly reacting antibody against the viral glycoprotein gp 71. (1979) (50)
Origins and properties of hematopoietic growth factor-dependent cell lines. (1989) (50)
Hepatocyte growth factor stimulates growth of hematopoietic progenitor cells. (1993) (49)
Murine B‐cell stimulatory factor‐1 (BSF‐1)/Interleukin‐4 (IL‐4) is a multilineage colony‐stimulating factor that acts directly on primitive hemopoietic progenitors (1989) (48)
Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines (1987) (48)
Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame (1994) (48)
Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. (1998) (48)
Multiple hemopoietic lineages are found after stimulation of mouse bone marrow precursor cells with interleukin 3. (1984) (47)
Signal transduction through the receptor for erythropoietin. (1993) (45)
Purified interleukin-3 and erythropoietin support the terminal differentiation of hemopoietic progenitors in serum-free culture. (1986) (45)
Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. (1995) (45)
Antigenic specificities of the cellular immune response of C57BL/6 mice to the Moloney leukemia/sarcoma virus complex. (1979) (45)
Characterization of the blastogenic and cytotoxic responses of normal mice to ecotropic C-type viral gp71. (1977) (44)
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons (2008) (44)
Gene Marking and Autologous Bone Marrow Transplantation a (1994) (44)
2 Cytokine receptors and signal transduction (1994) (44)
Characterization of the type and group specificities of the immune response in mice to murine leukemia viruses (1976) (42)
Induction of growth alterations in factor-dependent hematopoietic progenitor cell lines by cocultivation with irradiated bone marrow stromal cell lines. (1986) (42)
Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin. (1993) (41)
Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway. (2008) (41)
T cell recognition of Moloney leukemia virus proteins. III. T cell proliferative responses against gp70 are associated with the production of a lymphokine inducing 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes. (1981) (41)
Interleukins and lymphocyte activation. (1982) (41)
Phenotypic heterogeneity of Moloney leukemia virus-induced T cel lymphomas. (1980) (40)
Stromal growth factor production in irradiated lectin exposed long-term murine bone marrow cultures. (1987) (39)
The human Evi-1 gene is located on chromosome 3q24-q28 but is not rearranged in three cases of acute nonlymphocytic leukemias containing t(3;5)(q25;q34) translocations. (1990) (39)
His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia. (1991) (38)
Interleukin-3 and Hematopoiesis (Part 1 of 2) (1992) (38)
Gadd45γ Is Dispensable for Normal Mouse Development and T-Cell Proliferation (2001) (38)
The Centrosomal, Putative Tumor Suppressor Protein TACC2 Is Dispensable for Normal Development, and Deficiency Does Not Lead to Cancer (2004) (37)
Inactivation of murine xenotropic oncornavirus by normal mouse sera is not immunoglobulin-mediated. (1976) (37)
An Early Onset Progressive Motor Neuron Disorder in Scyl1-Deficient Mice Is Associated with Mislocalization of TDP-43 (2012) (36)
Effects of Polyadenylic Acids on Functions of Murine RNA Tumor Viruses (1973) (35)
Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation. (2003) (35)
Infection of immune mast cells by Harvey sarcoma virus: immortalization without loss of requirement for interleukin-3 (1985) (35)
Biochemical and biological properties of interleukin-3: a lymphokine mediating the differentiation of a lineage of cells that includes prothymocytes and mastlike cells. (1985) (34)
Dual effects of pertussis toxin on lymphoid cells in culture. (1986) (33)
Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells (1987) (33)
The Identification of JAK2 Tyrosine Kinase as a Signaling Molecule for Growth Hormone (1994) (33)
Autogenous immunity to mouse mammary tumor virus in mouse strains of high and low mammary tumor incidence. (1976) (33)
Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. II. Response in C57BL/6 mice. (1976) (32)
The Action of Interleukin-2 Receptor Subunits Defines a New Type of Signaling Mechanism for Hematopoietin Receptors in Hepatic Cells and Fibroblasts (*) (1995) (32)
Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. (1999) (31)
Genetic mapping of the mouse interleukin 3 gene to chromosome 11. (1987) (31)
The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells. (1989) (31)
Natural immunity to endogenous oncornaviruses in mice. (1977) (30)
Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin (1993) (30)
Biologic properties of interleukin 3. II. Serologic comparison of 20-alpha-SDH-inducing activity, colony-stimulating activity, and WEHI-3 growth factor activity by using an antiserum against IL 3. (1984) (30)
Phase I study of cytokine-gene modified autologous neuroblastoma cells for treatment of relapsed/refractory neuroblastoma. (1992) (30)
Mechanisms of C-type viral leukemogenesis. I. Correlation of in vitro lymphocyte blastogenesis to viremia and leukemia. (1979) (30)
Serological and virological analysis of NIH (NIH X AKR) mice: evidence for three AKR murine leukemia virus loci. (1978) (30)
AUTOGENOUS IMMUNITY TO ENDOGENOUS RNA TUMOR VIRUS (1973) (28)
Autogenous Immunity to Endogenous RNA Tumor Virus: Differential Reactivities of Immunoglobulins M and G to Virus Envelope Antigens (1974) (28)
Distribution of terminal deoxynucleotidyl transferase in bovine serum albumin gradient-fractionated thymocytes and bone marrow cells of normal and leukemic mice. (1977) (28)
Ars 2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation (2010) (28)
A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. (2006) (28)
Autologous bone marrow transplant for children with AML in first complete remission: use of marker genes to investigate the biology of marrow reconstitution and the mechanism of relapse. (1991) (27)
Characterization of a Family of Novel Cysteine- Serine-Rich Nuclear Proteins (CSRNP) (2007) (27)
Assessment of the efficacy of purging by using gene marked autologous marrow transplantation for children with AML in first complete remission. (1994) (27)
Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia (1989) (27)
Control of differentiation of thymocyte precursors in the bone marrow by thymic hormones. (1978) (26)
Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6. (1992) (26)
Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia. (2006) (26)
Expression of AKR murine leukemia virus gp71-like and BALB(X) gp-71- like antigens in normal mouse tissues in the absence of overt virus expression (1977) (26)
Experimental models and conceptual approaches to studies of lymphomas and leukemia: etiology, biology, and control. (1978) (25)
Radiation leukemia in C57BL/6 mice. III. Correlation of altered expression of terminal deoxynucleotidyl transferase to induction of leukemia (1978) (25)
Strain-, age-, and tumor-dependent distribution of terminal deoxynucleotidyl transferase in thymocytes of mice. (1976) (25)
Mechanisms in T cell leukemogenesis. II. T cell responses of preleukemic BALB/c mice to Moloney leukemia virus antigens. (1981) (25)
Possible immunological mechanisms in C-type viral leukemogenesis in mice. (1982) (25)
Increased responses to lymphokines are correlated with preleukemia in mice inoculated with Moloney leukemia virus. (1981) (24)
Natural immunity in mice to the envelope glycoprotein of endogenous ecotropic type C viruses: neutralization of virus infectivity (1977) (24)
Effects of recombinant human hematopoietic growth factors on leukemic blasts from children with acute myeloblastic or lymphoblastic leukemia. (1993) (24)
Interleukin 3 dependent retrovirus induced lymphomas: loss of the ability to terminally differentiate in response to differentiation factors. (1984) (24)
VIRUS IDENTIFICATION OF ANTIBODY REACTIVITY TO SELECT VIRAL ANTIGENS (1974) (24)
Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway. (2008) (24)
Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily. (1994) (24)
Signaling by the cytokine receptor superfamily just another kinase story (1994) (23)
Chimeric Erythropoietin-Interferon γ Receptors Reveal Differences in Functional Architecture of Intracellular Domains for Signal Transduction* (1997) (23)
Further characterization of the oncornavirus inactivating factor in normal mouse serum. (1979) (23)
Trophoblast Stem Cells Rescue Placental Defect in SOCS3-deficient Mice* (2006) (23)
Interleukin 3 (IL-3) induces transcription from nonrearranged T cell receptor gamma loci in IL-3-dependent cell lines (1989) (23)
Molecular cloning and characterization of murine leukemia virus-related DNA sequences from C3H/HeN mouse DNA (1982) (22)
Detection of a recombinant murine leukemia virus-related glycoprotein on virus-negative thymoma cells. (1981) (22)
Granulocyte colony-stimulating factor corrects the neutropenia associated with glycogen storage disease type Ib. (1991) (22)
Genetic analysis of the endogenous C3H murine leukemia virus genome: evidence for one locus unlinked to the endogenous murine leukemia virus genome of C57BL/6 mice. (1978) (22)
The roles of Jaks and Stats in cytokine signaling. (1998) (21)
Effect of glucocorticoids on activation of leukemia virus in AKR mouse embryo cells. (1975) (21)
Interleukins 2 and 3 regulate the in vitro proliferation of two distinguishable populations of 20-alpha-hydroxysteroid dehydrogenase-positive cells. (1985) (21)
Jak 1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor (1997) (21)
B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. (1978) (20)
Rescue of a thymotropic, leukemogenic C-type virus from cultured, nonproducer-lymphoma cells of strain C57BL/Ka mice. (1979) (20)
Inefficient humoral immune response of lymphoma-prone wild mice to persistent leukemia virus infection. (1976) (18)
Membrane localization is not required for Mpl function in normal hematopoietic cells. (2001) (18)
Assessment of reactivities of natural antibodies to endogenous RNA tumor virus envelope antigens and virus-induced cell surface antigens. (1975) (18)
Genes and gene products involved in growth regulation of tumor cells. (1985) (18)
Insertional mutagenesis and the transformation of hematopoietic stem cells. (1993) (18)
Different serotypes of B-tropic murine leukemia viruses and association with endogenous ecotropic viral loci. (1980) (17)
Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. III. Influence on endogenous MuLV-mediated pathogenesis. (1976) (16)
Evi-1 expression in Xenopus. (2005) (16)
Properties of mouse leukemia viruses. XVII. Factors required for successful treatment of spontaneous AKR leukemia by antibodies against gp71. (1981) (15)
The Evi-1 zinc finger myeloid transforming protein binds to genomic fragments containing (GATA)n sequences. (1995) (15)
A phase I trial of high-dose carboplatin and etoposide with autologous marrow support for treatment of stage D neuroblastoma in first remission: use of marker genes to investigate the biology of marrow reconstitution and the mechanism of relapse. (1991) (15)
Gadd45gamma is dispensable for normal mouse development and T-cell proliferation. (2001) (15)
Resistance of cultures of normal T cells to infection with murine type C viruses (1981) (14)
Properties of mouse leukemia viruses XVIII. Effective treatment of AKR leukemia with antibody to gp7l eliminates the neonatal burst of ecotropic AKR virus producing cells (1982) (14)
Stat 5 a / b contribute to interleukin 7 – induced B-cell precursor expansion , but abl-and bcr / abl-induced transformation are independent of Stat 5 (2000) (14)
Properties of mouse leukemia viruses. XIX. Effective antibody therapy of AKR leukemia occurs independently of virus neutralization and produces long-term changes in the virus status of the thymus. (1984) (14)
Cytokine receptors and signal transduction. (1994) (14)
Lack of alterations in the cytoplasmic domains of the granulocyte colony-stimulating factor receptors in eight cases of severe congenital neutropenia. (1995) (14)
Signaling by the Hematopoietic Cytokine Receptors (1996) (14)
Autogenous immunity to endogenous RNA tumor virus: reactivity of natural immune sera to antigenic determinants of several biologically distinct murine leukemia viruses. (1975) (14)
A microassay for colony-stimulating factor based on thymidine incorporation. (1984) (13)
The immune response to C-type viruses and its potential role in leukemogenesis. (1982) (13)
T cell recognition of Moloney sarcoma virus proteins during tumor regression. I. Lack of a requirement for macrophages and the role of blastogenic factors in T cell proliferation. (1981) (13)
Recombinant human TNF-alpha stimulates the secretion of granulocyte colony-stimulating factor in vivo. (1992) (12)
Expression of EVIl in Myelodysplastic Syndromes and Other Hematologic Malignancies Without 3 q 26 Translocations (2002) (12)
Inhibition of normal mouse lymphocyte mitogen responses by xenogeneic or allogeneic antibodies to the MuLV glycoprotein gp71. (1976) (11)
The humoral immune response of NIH Swiss and SWR/J mice to vaccination with formalinized AKR or Gross murine leukemia virus. (1977) (11)
The Temporal Separation of Transcription and Translation and its Control in Cotton Embryogenesis and Germination (1972) (11)
Biologic effects of prolonged melphalan treatment of murine long-term bone marrow cultures and interleukin 3-dependent hematopoietic progenitor cell lines. (1985) (10)
Interleukin-4 and-13 Induce Upregulation of the Murine Macrophage 12 / 15-Lipoxygenase Activity : Evidence for the Involvement of Transcription Factor STAT (1998) (10)
Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT/enhancer-binding protein e (2001) (9)
Phenotypes and mechanisms in the transformation of hematopoietic cells. (1990) (9)
Evidence for a Stable Intermediate in Leukemia Virus Activation in AKR Mouse Embryo Cells (1974) (9)
Unique pathway of IL-3-driven hemopoietic differentiation. (1989) (9)
Homogeneous interleukin 3 enhances arginase activity in murine hematopoietic cells. (1985) (9)
of Stat 5 . Naturally occurring dominant negative variants (1996) (8)
Strain-dependent development of an autogenous immune response in mice to endogenous C type viruses. (1975) (8)
Comparison of allogeneic and self-restricted stimulation of lymphokine production by dual-reactive cloned T cells. (1984) (8)
Monoclonal antibodies to the envelope proteins of Moloney leukemia virus: characterization of recombinant viruses. (1980) (8)
Lack of constitutive activation of Janus kinases and signal transduction and activation of transcription factors in Philadelphia chromosome-positive acute lymphoblastic leukemia. (1996) (8)
Pathways in Cytokine Regulation of Hematopoiesis (2001) (8)
Abrogation of IL-3 dependence of myeloid FDC-P1 cells by tyrosine kinase oncogenes is associated with induction of c-myc. (1988) (7)
Subunit structure of the erythropoietin receptor analyzed by 125I-Epo cross-linking in cells expressing wild-type or mutant receptors (1993) (7)
Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice. (1976) (7)
A phase I trial of high-dose carboplatin and etoposide with autologous marrow support for treatment of relapse/refractory neuroblastoma without apparent bone marrow involvement: use of marker genes to investigate the biology of marrow reconstitution and the mechanism of relapse. (1991) (7)
NATURAL CYTOTOXIC ACTIVITY OF MOUSE SPLEEN CELL CULTURES MAINTAINED WITH INTERLEUKIN-3 (1982) (6)
T cell recognition of Moloney sarcoma virus proteins. II. Phenotypes of the different lymphocyte subpopulations producing and responding to blastogenic factors and their relative frequencies during tumor regression. (1981) (6)
Characterization of a unique defective type C virus associated with a Moloney leukemia virus-induced splenic T-cell lymphoma cell line (1980) (6)
Books also Received (1955) (6)
Autogenous immunity to endogenous RNA tumor virus: humoral immune response to virus envelope antigens. (1976) (5)
The effect of altered lymphocyte function on the immunologic disorders of NZB/NZW mice. Response to anti-thymocyte globulin. (1977) (5)
Isolation and characterization of a unique C57BL B-tropic virus. (1980) (5)
Variations in the human phospholipase Cγ2 gene in patients with B-cell defects of unknown etiology (2001) (5)
Biochemical and Biological Properties of Interleukin-3 (1984) (4)
Structural and functional analysis of the promoter of the murine Vγ1.1 T cell receptor gene (1995) (4)
Differential roles of cytokine signaling during T-cell development. (1999) (4)
Interleukin 3 regulation of hematopoietic stem cell differentiation. (1985) (4)
Interleukin-3 and Hematopoiesis (Part 2 of 2) (1992) (4)
Mechanisms in the transformation of IL3-dependent hematopoietic stem cells. (1989) (4)
AKR-MuLV-associated cell surface antigens (2005) (4)
Comparison of sequence homology of poly(A) and non-poly(A) containing 34S RNA of AKR murine leukemia virus. (1977) (4)
Deregulation of the c-myc and N-myc genes in transformed cells. (1988) (3)
The 4-6-8 method of sequence analysis. (1988) (3)
Insertional mutagenesis and transformation of hematopoietic stem cells. (1990) (2)
Regulation of T cell receptor gamma gene expression by cytokines in murine hematopoietic cells. (1995) (2)
The antiapoptotic function of megakaryocyte growth and development factor (Peg-rmMGDF) Is disrupted in STAT5ab−/− and JAK2+/− mice (2000) (2)
Mechanisms of C-Type Viral Leukemogenesis (1979) (2)
Tumor-associated immunoglobulins, antitumor antibodies, and antiviral antibodies in C. parvum-treated normal and tumor-bearing mice (1978) (2)
Immunological Regulation of Hematopoietic Stem Cell Function by Interleukin 3 and Its Role in Leukemogenesis (1988) (2)
Immunological regulation of hematopoietic stem cell differentiation by interleukin-3. (1985) (2)
Transformation and insertional mutagenesis in vitro of primary hematopoietic stem cell cultures. (1986) (2)
Oncogenic and immunogenic potential of cloned HIX virus in mice and cats (2005) (2)
Mechanisms in interleukin 3 regulated growth and differentiation. (1987) (1)
Purification and characterization of a murine tumor cell surface glycoprotein of 75,000 daltons that is related to the major envelope glycoprotein of murine leukemia virus. (1978) (1)
Characteristics of IL-3 derived and IL-3 dependent lymphocyte cell lines. (1982) (1)
Contemporary Topics in Immunobiology (1977) (1)
Multiple lymphokine activities are secreted by a cloned murine T helper cell (1982) (1)
Terminal transferase. Enzyme marker for a specific prothymocyte cell population. Abstr. (1977) (1)
XVIII. Effective treatment of AKR leukemia with antibody to gp7 1 eliminates the neonatal burst of ecotropic AKR virus producing cells. (1982) (1)
Glucocorticoid control of gene expression (1975) (1)
but abl- andbcr/abl-induced transformation are independent of Stat5 induced B-cell precursor expansion, - Stat5a/b contribute to interleukin 7 (2013) (1)
Transforming Genes: Oncogenes, Genes, and Growth Factors . Gordon Guroff, Ed. Wiley-Interscience, New York, 1987. xiv, 386 pp., illus. $69.95.; Oncogenes and Growth Control . Patricia Kahn and Thomas Graf, Eds. Springer-Verlag, New York, 1986. xxiv, 369 pp., illus. $69.50. (1987) (0)
CHAPTER 74 – Cytokine Receptor Superfamily Signaling (2003) (0)
The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1 (1987) (0)
Gadd 45 g Is Dispensable for Normal Mouse Development and T-Cell Proliferation (2001) (0)
Structure ofthemurineJak2protein-tyrosine kinase anditsrolein interleukin 3signal transduction (1993) (0)
Structural and functional analysis of the promoter of the murine V gamma 1.1 T cell receptor gene. (1995) (0)
Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci (1996) (0)
Kinases appartenant a la famille jak et regulation de la transduction du signal de la cytokine (1994) (0)
Further characterization of b-tropic murine leukemia viruses isolated from c57bl mice. Abstr. (1979) (0)
Effects ofPolyadenylic Acids on Functions of MurineRNA TumorViruses (1973) (0)
Insertion andTruncation ofc-mybbyMurineLeukemiaVirusina Myeloid CellLineDerived fromCultures ofNormal Hematopoietic Cells (1987) (0)
IL-4 and IL-3 but are not required proteins that are tyrosine phosphorylated in Cloning of murine Stat 6 and human Stat 6 , Stat (1995) (0)
CHARACTERIZATION OF CELLULAR INTERACTIONS WITH BLASTOGENIC FACTOR(S) IN ANTIGEN-SPECIFIC LYMPHOPROLIFERATIVE RESPONSES (1981) (0)
Signal Transducers and Activators of Transcription in Cytokine Signaling (2003) (0)
Transforming Genes. (Book Reviews: Oncogenes, Genes, and Growth Factors; Oncogenes and Growth Control) (1987) (0)
Interaction of Interleukin 3 with Pluripotent Hematopoietic Stem Cells (1986) (0)
[40] Interleukin 3 (1985) (0)
Hematopoietic Cytokine Receptor Signaling (1996) (0)
Feline Lymphomas: Immunological and Cytochemical Characterization1 (2006) (0)
The relative roles of interleukins 1, 2, and 3 in the regulation of T cell differentiation. (1984) (0)
PRODUCTION OF INTERLEUKIN-3 BY MURINE TUMOR CELLS (1982) (0)
[Biology, serology and biochemistry of leucemogenic viruses derived from a radiation-induced tumor of C57BL mice]. (1980) (0)
Immuno-prophylaxis and -therapy of C-type oncorna viral diseases in mice and cats (2005) (0)
Childhood Leukemias: Signal transduction in the regulation of hematopoiesis (2006) (0)
murine myeloid tumors. integration site, Evi-1, in the DNA of AKXD Identification of a common ecotropic viral (2013) (0)
The molecular and cellular biology of interleukin-3. (1989) (0)
Autogenous immunity to mouse mammary tumor virus in high and low mammary tumor bearing mice. Abstr. (1976) (0)
Gadd45 g Is Dispensable for Normal Mouse Development and T-Cell Proliferation (2001) (0)
Regulation of gene expression and viral neoplasia (1973) (0)
Multiple Hemoopoietic Lineages Are Found After Stimulation of Mouse Bone Marrow Precursor Cells With Interleulin 3 (2007) (0)
Table of Contents (1996) (0)
AUTOGENOUS IMMUNITY TO RNA TUMOR VIRUS activity (0)
Mechanisms in interleukin-3 regulated growth and differentiation of hematopoietic cells. (1987) (0)
Chronic blastogenesis to endogenous viral antigen(s): a possible mechanism for c-type viral leukemogenesis. Abstr. (1979) (0)
Correction (2001) (0)
Childhood Leukemias: Hematopoietic growth factors (2006) (0)
Interferon Therapy During the Plateau Phase of Multiple Myeloma: An Update of the Swedish Study Jan Westin, Agostino Cortelezzi, Martin Hjorth, Stig Rhljer, Ingemar Turesson and G&an Zador for a cooperative study group (1991) (0)
Interleukin 3: Regulation of the differentiation and growth of 20-α-hydroxysteroid-positive lymphocytes (1982) (0)
Induction of an enzyme marker for mature t cells in athymic mice. Abstr. (1980) (0)
Characterization oftheTypeandGroupSpecificities ofthe ImmuneResponse inMicetoMurineLeukemia Viruses (1976) (0)
Interleukin-3 regulation of the growth and differentiation of hematopoietic lymphoid stem cells. (1986) (0)
The immune response of (C57BL/6 X C3H)F1 mice to the endogenous AKR-MuLV (2005) (0)
Amino- and carboxyl-terminal ami coded by gag gene of murine leuke) (2016) (0)
The Evi‐1 zinc finger protein and transformation of hematopoietic progenitors (1991) (0)
erythroblastosis and polycythemia Role of erythropoietin receptor signaling in Friend virus-induced (2013) (0)
Mechanisms of IL-3 Regulated Growth and Transformation of Hematopoietic Cells (1989) (0)
Transforming genes: oncogenes, genes, and growth factors. (1987) (0)
Thmsformation and Insertional Mutagenesis In Vitro of Primary Hematopoietic Stem CeO Cultures (0)
Tumor virus envelope antigens and virus-induced cell surface antigens. (1975) (0)
Endogenous N-Terminal Truncated STAT5 Expressed from Alternative Start Codons Promotes SCF Signaling in Murine Primary Mast Cell Cultures. (2004) (0)
Abstract 3691: Deletion of Suppressor Of Cytokine Signaling-1 in a Murine Model of Atherosclerosis Results in a Lethal Systemic Inflammation (2008) (0)
Restoration of lymphopoiesis in Jak3 deficient scid mice with IL-3. (1997) (0)

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