James R. Gillette

James R. Gillette's AcademicInfluence.com Rankings

James R. Gillette

Medical

#853

World Rank

#1112

Historical Rank

Toxicology

World Rank

Historical Rank

Pharmacology

#54

World Rank

#74

Historical Rank

medical Degrees

James R. Gillette

Chemistry

#1271

World Rank

#1954

Historical Rank

chemistry Degrees

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Medical
Chemistry

James R. Gillette's Degrees

PhD Pharmacology University of California, San Francisco
Bachelors Chemistry University of California, Berkeley

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James R. Gillette's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. (1974) (2848)
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. (1973) (1667)
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. (1973) (1443)
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. (1973) (1152)
EFFECT OF STARVATION ON NADPH-DEPENDENT ENZYMES IN LIVER MICROSOMES OF MALE AND FEMALE RATS (1965) (518)
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. (1973) (480)
Enzymatic metabolism of drugs and other foreign compounds. (1958) (454)
Microsomes and drug oxidations (1968) (438)
Cytochrome P-450 and its role in drug metabolism. (1972) (361)
The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen. (1957) (354)
Possible mechanism of liver necrosis caused by aromatic organic compounds. (1971) (351)
FACTORS AFFECTING DRUG METABOLISM (1971) (346)
Acetaminophen-induced hepatotoxicity. (1981) (344)
Biochemical Mechanisms of Drug Toxicity (1974) (319)
Drug interaction with hepatic microsomal cytochrome. (1966) (316)
Biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic reticulum. (1966) (314)
Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes. (1965) (244)
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates. (1969) (243)
SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI). (1964) (232)
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity. (1974) (218)
Role of detoxifying enzymes in bromobenzene-induced liver necrosis. (1973) (201)
Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450. (1977) (195)
Diverse effects of SKF 525-A and antioxidants on carbon tetrachloride-induced changes in liver microsomal P-450 content and ethylmorphine metabolism. (1968) (160)
Studies on the mechanism of the lung toxicity of paraquat: comparison of tissue distribution and some biochemical parameters in rats and rabbits. (1974) (160)
OVERVIEW OF DRUG‐PROTEIN BINDING (1973) (158)
The distribution of the components of mixed-function oxidase between the rough and the smooth endoplasmic reticulum of liver cells. (1968) (154)
Effect of ambient ammonia on blood ammonia and nitrogen excretion of rainbow trout (Salmo gairdneri). (1968) (152)
Prevention of carbon tetrachloride-induced necrosis by inhibitors of drug metabolism--further studies on their mechanism of action. (1974) (152)
Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. (1976) (151)
Induced Synthesis of Liver Microsomal Enzymes Which Metabolize Foreign Compounds (1959) (149)
Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration. (1968) (142)
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. (1987) (140)
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s. (1990) (134)
Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. (1985) (133)
Drug metabolism as a cause of drug toxicity. (1973) (133)
Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes. (1985) (128)
Enzymatic pathway for the formation of cotinine, a major metabolite of nicotine in rabbit liver. (1960) (127)
Studies on the mechanism of action of mammalian hepatic azoreductase. I. Azoreductase activity of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase. (1967) (123)
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding. (1974) (121)
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH. (1968) (119)
Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism. (1974) (112)
Theoretical studies on cytochrome P-450 mediated hydroxylation: a predictive model for hydrogen atom abstractions (1990) (111)
Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation. (1969) (106)
A comparison of the teratogenic activity of thalidomide in rabbits and rats. (1968) (105)
Metabolism of Drugs and Other Foreign Compounds by Enzymatic Mechanisms (1963) (103)
Mechanism of p-nitrobenzoate reduction in liver: the possible role oc cytochrome P-450 in liver microsomes. (1968) (100)
Generation of reactive metabolites of N-hydroxy-phenacetin by glucoronidation and sulfation. (1977) (98)
Enzymatic reduction of niridazole by rat liver microsomes. (1971) (97)
Concepts in Biochemical Pharmacology (1975) (96)
Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. (1987) (92)
Effect of spironolactone on sex hormones in man. (1975) (88)
3H-Benzene metabolism in rabbit bone marrow. (1979) (87)
Theoretic aspects of pharmacokinetic drug interactions (1977) (86)
Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin. (1978) (85)
Sex differences in the kinetic constants for the N-demethylation of ethylmorphine by rat liver microsomes. (1968) (83)
Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus. (1989) (81)
Studies on the mechanism of action of mammalian hepatic azoreductase. II. The effects of phenobarbital and 3-methylcholanthrene on carbon monoxide sensitive and insensitive azoreductase activities. (1967) (80)
Effects of Caffeine and Theophylline on Activity of Rats in Relation to Brain Xanthine Concentrations 1 (1972) (80)
N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen. (1979) (79)
The effect of phenobarbital on the turnover of microsomal phospholipid in male and female rats. (1968) (79)
Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450. (1979) (79)
Reduction of niridazole by rat liver santhine oxidase. (1971) (75)
The role of biotransformation in chemical-induced liver injury. (1976) (73)
Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. (1989) (72)
Immunochemical evidence of trifluoroacetylated cytochrome P-450 in the liver of halothane-treated rats. (1985) (71)
3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen. (1980) (69)
An unusual metabolite of testosterone. 17 beta-Hydroxy-4,6-androstadiene-3-one. (1986) (69)
Disulfiram impairment of drug metabolism by rat liver microsomes. (1969) (67)
Enhanced Hepatic Microsomal Activity by Pretreatment of Rats with Acetone or Isopropanol (1973) (65)
The effect of anabolic steroids on drug metabolism by microsomal enzymes in rat liver. (1962) (64)
Species and sex differences in the kinetic constants for the N-demethylation of ethyl-morphine by liver microsomes. (1967) (64)
The effect of spironolactone on drug metabolism by hepatic microsomes. (1971) (63)
Interindividual differences in amitriptyline demethylation (1980) (63)
Bromobenzene and p-bromophenol toxicity and covalent binding in vivo. (1982) (62)
Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene. (1968) (61)
Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). (1974) (59)
Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates. (1978) (59)
Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with postnatal development and maturation in male rats. (1969) (58)
The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats. (1974) (57)
Side chain oxidation of alkyl substituted ring compounds. I. Enzymatic oxidation of p-nitrotoluene. (1959) (55)
Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae. (1991) (55)
Changes in Michaelis and spectral constants for aniline in hepatic microsomes from phenobarbital-treated rats. (1969) (54)
Alterations in kinetic constants for hepatic microsomal aniline hydroxylase and ethylmorphine N-demethylase associated with pregnancy in rats. (1969) (54)
Spironolactone and cytochrome P-450: impairment of steroid 21-hydroxylation in the adrenal cortex. (1976) (53)
Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: implications for bromobenzene-induced nephrotoxicity. (1984) (53)
Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: cytochrome P-450. (1989) (53)
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes. (1971) (52)
Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism. (1970) (51)
FACTORS THAT AFFECT THE STIMULATION OF THE MICROSOMAL DRUG ENZYMES INDUCED BY FOREIGN COMPOUNDS. (1963) (50)
Disposition of thalidomide in rabbits and rats. (1968) (50)
The role of ortho-bromophenol in the nephrotoxicity of bromobenzene in rats. (1984) (48)
Investigation of the effects of methyltestosterone, cortisone and spironolactone on the hepatic microsomal mixed function oxidase system in male and female rats. (1973) (47)
Studies on the inhibitory effects of various substances on drug metabolism by liver microsomes: The effect of nicotinamide in altering the apparent mechanism of inhibition (1970) (47)
The enzymatic formation of sulfoxides: the oxidation of chlorpromazine and 4,4'-diaminodiphenyl sulfide by guinea pig liver microsomes. (1960) (47)
Toxic Drug Reactions (1975) (45)
Effects of induction of cytochrome P-450 enzymes on the concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds. (1979) (44)
The effect of starvation on the kinetics of drug oxidation by hepatic microsomal enzymes from male and female rats. (1970) (43)
Mechanism of stimulation of mammalian nitro reductase by flavins. (1963) (43)
Biotransformation of drugs. (1978) (42)
Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters. (1979) (41)
Isotope effect studies on the mechanism of the cytochrome P-450IIA1-catalyzed formation of delta 6-testosterone from testosterone. (1990) (41)
DRUG TOXICITY AS A RESULT OF INTERFERENCE WITH PHYSIOLOGICAL CONTROL MECHANISMS (1965) (40)
A study of the oxidation-reduction state of synthetic 3,4-dihydroxy-DL-phenylalanine melanin. (1971) (40)
Isozymes of cytochrome P-450 that metabolize naphthalene in liver and lung of untreated mice. (1990) (40)
Relationship between NADH and NADPH oxidation during drug metabolism. (1973) (38)
Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes. (1969) (37)
Sequential first-pass elimination of a metabolite derived from a precursor (1979) (37)
A perspective on halothane-induced hepatotoxicity. (1982) (36)
[The effect of desmethylimipramine and other "anti-tremorine" drugs on the metabolism of tremorine and oxotremorine in rats and mice]. (1968) (36)
The effect of carbon tetrachloride on heme components and ethylmorphine metabolism in rat liver microsomes. (1969) (35)
Stereoselective formation of bromobenzene glutathione conjugates. (1982) (35)
Multiple reactive metabolites derived from bromobenzene. (1984) (34)
Drugs and enzymes (1965) (34)
Pre- and postnatal enzyme capacity for drug metabolite production. (1975) (34)
Diffusion of reactive metabolites out of hepatocytes: studies with bromobenzene. (1984) (34)
Spironolactone and cytochrome P-450: impairment of steroid hydroxylation in the adrenal cortex. (1974) (33)
Studies on the mutagenicity of N-hydroxy-2-acetylaminofluorene in the Ames-Salmonella mutagenesis test system. (1978) (32)
A prospective on covalent binding and toxicity. (1977) (30)
The effect of phenobarbital on the synthesis of microsomal phospholipid in female and male rats. (1966) (29)
The catalysis of the oxidation of some dihydroxybenzene derivatives by various metallic ions. (1954) (29)
Investigation of the immunological basis of halothane-induced hepatotoxicity. (1986) (29)
Biotransformation of drugs during aging. (1979) (29)
The metabolic products of naphthalene in mammalian systems. (1967) (29)
Active products of fetal drug metabolism (1973) (28)
Prolongation and potentiation of oxotremorine effects by desmethylimipramine an "anti-tremorine" drug. (1965) (27)
Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase. (1991) (27)
Formation of chemically reactive metabolites of phenacetin and acetaminophen. (1981) (27)
Metabolite pharmacokinetics: methods for simultaneous estimates of elimination rate constants of a drug and its metabolite. A commentary. (1980) (26)
Theoretical relationships between area under the curve and route of administration of drugs and their precursors for evaluating sites and pathways of metabolism. (1978) (26)
Effect of steroids on drug metabolism in male and female rats. (1973) (26)
The problem of chemically reactive metabolites. (1982) (26)
Mechanisms of inhibition of drug metabolic reactions. (1973) (25)
Detection and half-life of bromobenzene-3,4-oxide in blood. (1984) (24)
Other Aspects of Pharmacokinetics (1975) (24)
Theory for the observed isotope effects on the formation of multiple products by different kinetic mechanisms of cytochrome P450 enzymes. (1994) (23)
CYTOCHROME P-450 REDUCTION IN LIVER MICROSOMES AND ITS RELATIONSHIP TO DRUG METABOLISM (1969) (23)
A comparison of the effects of halothane and CCl 4 on the hepatic drug metabolizing system. (1971) (23)
Determination of toxic pathways of metabolism by deuterium substitution. (1984) (22)
Application of pharmacokinetic principles in the extrapolation of animal data to humans. (1976) (22)
Kinetics of Reactive Metabolites and Covalent Binding in Vivo and in Vitro (1977) (21)
The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs (1978) (21)
An integrated approach to the study of chemically reactive metabolites of acetaminophen. (1981) (21)
Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat. (1978) (21)
The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes. (1981) (21)
cDNA‐directed expression of rat testosterone 7α‐hydroxylase using the modified vaccinia virus, T7‐RNA‐polymerase system and evidence for 6α‐hydroxylation and Δ6‐testosterone formation (1989) (21)
Microsomes, endoplasmic reticulum and interactions of cytoplasmic membranes (1969) (21)
Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil) (1961) (21)
Reduced body clearance as the major mechanism of the potentiation by beta2-adrenergic agonists of paraquat lethality in rats. (1978) (20)
9 – Biotransformation of Drugs (1971) (20)
High-performance liquid chromatographic assay for acetaminophen and phenacetin in the presence of their metabolites in biological fluids. (1979) (19)
Intra- and extra-cellular formation of metabolites from chemically reactive species. (1984) (19)
Metabolism, tissue distribution and covalent binding of tripelennamine and its N-nitroso derivative in the rat. (1975) (18)
The kinetics of 32P incorporation into the phospholipids of hepatic rough and smooth microsomal membranes of male and female rats. (1970) (18)
Ascorbic acid inhibits covalent binding of enzymatically generated 2-acetyl-aminofluororene-N-sulfate to DNA under conditions in which it increases mutagenesis in salmonella TA-1538. (1979) (17)
Isotope effect studies on the cytochrome P450 enzymes. (1995) (17)
Effect of different routes of administration of cedrene on hepatic drug metabolism. (1972) (17)
Specificity of the in vitro destruction of adrenal and hepatic microsomal steroid hydroxylases by thiosteroids. (1979) (17)
An immunochemical approach to investigating the mechanism of halothane-induced hepatotoxicity (1987) (17)
Environmental factors in drug metabolism. (1976) (17)
The incorporation of 18-O into naphthalene in the enzymatic formation of 1,2-dihydronaphthalene-1,2-diol. (1967) (16)
Theoretical kinetics of sequential metabolism in vitro. Study of the formation of 16 alpha-hydroxyandrostenedione from testosterone by purified rat P450 2C11. (1994) (16)
A method for the estimation of the fraction of a precursor that is converted to a metabolite in rat in vivo with phenacetin and acetaminophen. (1979) (16)
Enzymatic oxidation of diphenylmethylphosphine and 3-dimethylaminopropyldiphenylphosphine by rat liver microsomes. (1972) (16)
Effect of dietary orotic acid and adenine sulfate on hepatic microsomal enzymes in male and female rats. (1969) (16)
Factors influencing the metabolism and distribution of corticosterone-1,2-3H in the rat. (1966) (16)
The formation of glutathione conjugate derived from propranolol. (1987) (16)
SIGNIFICANCE OF MIXED OXYGENASES AND NITROREDUCTASE IN DRUG METABOLISM (1969) (16)
Sequential organ first-pass effects: simple methods for constructing compartmental pharmacokinetic models from physiological models of drug disposition by several organs. (1982) (15)
Dealkylation of N-Alkylamines by Model Systems (1958) (15)
Deuterium isotope effects on A-ring and D-ring metabolism of testosterone by CYP2C11: evidence for dissociation of activated enzyme-substrate complexes. (1994) (15)
The Pennsylvania State University College of Medicine 1991 Bernard B. Brodie Lecture. Insights into deuterium isotope effects on the metabolism of steroid hormones and foreign compounds by cytochrome P-450 enzymes. (1991) (15)
Hepatic ethylmorphine demthylase and delta-4-steroid reductase in the androgen-insensitive pseudohermaphroditic rat. (1971) (15)
Kinetic evidence for multiple chemically reactive intermediates in the breakdown of phenacetin N-O-glucuronide. (1979) (14)
The inhibitory effects of endogenous NADPH-pyrophosphatase on the reduction of cytochrome c and the oxidation of drugs by liver microsomes. (1970) (14)
REVERSIBLE BINDING AS A COMPLICATION IN RELATING THE IN VITRO EFFECT OF DRUGS TO THEIR IN VIVO ACTIVITY (1965) (14)
The importance of tissue distribution in pharmacokinetics (1973) (14)
Concepts in Biochemical Pharmacology (1971) (14)
The mechanism of formation of o-bromophenol from bromobenzene. (1984) (13)
Reduction of Heterocyclic Nitro Compounds in the Rat Liver (1971) (13)
Kinetics of decomposition of chemically unstable metabolites in the presence of nucleophiles: derivation of equations used in graphical analyses. (1980) (13)
OVERVIEW OF FACTORS AFFECTING DRUG INTERACTIONS (1976) (12)
Significance of covalent binding of chemically reactive metabolites of foreign compounds to proteins and lipids. (1986) (12)
An approach measurement of the stoichiometric relationship between hepatic microsomal drug metabolism and the oxidation of reduced nicotinamide adenine dinucleotide phosphate. (1972) (12)
The use of theoretical pharmacokinetic concepts in studies of the mechanisms of formation of chemically reactive metabolites in vitro and in vivo. (1983) (11)
Effects of anti-NADPH-cytochrome c reductase and anti-cytochrome b5 antibodies on the hepatic and pulmonary microsomal metabolism and covalent binding of the pulmonary toxin 4-ipomeanol. (1978) (11)
Dibenamine impairment of rat hepatic microsomal enzymes and its relation to hepatotoxicity induced by CCl4 and dimethylnitrosamine. (1974) (11)
Some properties of the manganese and copper catalyzed oxidation of catechol and some other ortho-dihydroxybenzene derivatives. (1955) (11)
Formation of Reactive Drug Metabolites as a Basis of Drug Action and Toxicity (1975) (11)
Problems in Correlating In Vitro and In Vivo Studies of Drug Metabolism (1984) (11)
Enzymatic formation of chemically reactive metabolites of N-nitrosodesmethyl tripelennamine by a mechanism other than N-dealkylation. (1975) (11)
Acetylcholine formation in mouse brain and effect of cholinergic drugs. (1972) (11)
Cotinine: an Oxidation Product of Nicotine formed by Rabbit Liver (1959) (11)
cDNA-directed expression of rat P450s IIA1 and IIA2. Catalytic activities toward steroids and xenobiotics and comparison with the enzymes purified from liver. (1990) (11)
A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow (1978) (11)
Effect of chronic treatment with phenobarbital or 3-methylcholanthrene on the male reproductive system in rats. (1974) (10)
Factors That Affect Drug Concentrations in Maternal Plasma (1977) (10)
The role of cytochrome b5 in cytochrome P-450 enzymes. (1975) (10)
Effect of methylcholanthrene or phenobarbital pretreatment of rabbits and rats on the extinction coefficient for cytochrome P-450. (1971) (9)
Keynote address: man, mice, microsomes, metabolites, and mathematics 40 years after the revolution. (1995) (9)
Tetraethylammonium as a Probe for Estimating Renal Plasma Flow in Unanesthetized Rats 1 (1979) (9)
A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids. (1980) (9)
The Role of Sex Hormones in the Metabolism of Drugs and Other Foreign Compounds by Hepatic Microsomal Enzymes (1969) (8)
Drug Actions and Interactions: Theoretical Considerations (1975) (8)
12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2. (1992) (8)
Effects of bromobenzene and carbon tetrachloride on the synthesis and release of proteins by perfused rat liver. (1973) (8)
Pharmacokinetic procedures for the estimation of organ clearances for the formation of short-lived metabolites. Acetaminophen-induced glutathione depletion in hamster liver. (1988) (8)
Final report of the Color Additive Scientific Review Panel. (1986) (7)
Extinction coefficients for cytochrome P-450 in hepatic microsomes from male and female rats. (1971) (7)
Mechanisms in the potentiation and inhibition of pharmacological actions of hexobarbital and zoxazolamine by glycofurol. (1978) (7)
BIOCHEMICAL MECHANISMS FOR HEPATOTOXICITY PRODUCED BY DIETHYLSTILBESTROL (1972) (7)
Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites. (1980) (7)
Problems in risk assessment (1982) (6)
Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, NIH: a short history. (2000) (6)
Mechanism of hepatic necrosis induced by halogenated aromatic hydrocarbons (1975) (6)
Carbon-13 nuclear magnetic resonance studies of spironolactone and several related steroids (1980) (6)
On the role of pharmacokinetics in integrating results from in vivo and in vitro studies. (1986) (5)
Production of a dimer of 2-acetylaminofluorene during the sulfation of N-hydroxy-2-acetylaminofluorene in vitro. (1979) (5)
Metabolism of the B-ring of testosterone by the rat cytochrome P-450 system. (1989) (5)
AN OVERVIEW OF THE ROLE OF MICROSOMAL ENZYMES IN THE FORMATION OF TOXIC METABOLITES (1980) (5)
Effect of temperature on the relationship between hepatic microsomal cytochrome P-450 reduction and ethylmorphine demethylation. (1971) (4)
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity. (1972) (4)
Metabolic Activation of Methyldopa by Cytochrome P450-Generated Superoxide Anion (1977) (4)
Comments on comparative patterns of drug metabolism. (1967) (4)
Drug-nitrite interactions: the lack of toxicity of a N-nitroso derivative of tripelennamine formed in the rat. (1975) (3)
Sulfation in the metabolism and mutagenicity of N-hydroxy-2-fluorenylacetamide. (1981) (3)
Chapter 2 – Kinetic Aspects of Metabolism and Elimination of Foreign Compounds in Animals (1980) (3)
Methods of Biochemical Analysis (1958) (3)
Aspects of drug metabolism relating to pharmacologic activity. (1969) (3)
Overview: theoretical aspects of isotope effects on the pattern of metabolites formed by cytochrome P-450. (1991) (3)
CHAPTER 11 – Enzyme Induction in Laboratory Animals and its Relevance to Food Additive Investigation (1970) (3)
Fluoroacetate inhibition of fatty acid oxidation by liver preparations; a mechanism of action. (1950) (2)
Induction of liver microsomal activities in Japanese quail [with supplemental information on] the induction of microsomal ethylmorphine demethylase activity in sparrow hawk livers by diets containing DDT and dieldrin or DDE (1970) (2)
ON THE MECHANISM OF THE POTENTIATION BY BETA ADRENERGIC AGONISTS OF PARAQUAT TOXICITY IN RATS AND MICE (1977) (2)
19 – Pharmacokinetic Aspects of the Formation and Inactivation of Chemically Reactive Metabolites (1978) (2)
A new principle for estimating hepatic blood flow rates. (1981) (2)
Reactive Metabolites of Organohalogen Compounds (1975) (2)
The Second International Symposium on Microsomes and Drug Oxidations (1973) (2)
The nature of the extrahepatic covalent binding derived from bromobenzene (BB) (1982) (2)
Thalidomide solutions. (1966) (2)
Evaluation of Xenobiotic Metabolism (1987) (2)
280 Oxidation and reduction by microsomal enzymes (1961) (1)
Chapter 25: Comparative Toxicology (1976) (1)
cDNA-directed expression of rat testosterone 7 alpha-hydroxylase using the modified vaccinia virus, T7-RNA-polymerase system and evidence for 6 alpha-hydroxylation and delta 6-testosterone formation. (1989) (1)
Inactivation of horseradish peroxidase by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine. (1994) (1)
pH-dependent one- and two-electron oxidation of 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine catalyzed by horseradish peroxidase. (1994) (1)
Free radical intermediates and liver cell necrosis (1984) (1)
Studies on the activation of p-18O-phenacetin to a reactive metabolite in hamsters (1978) (1)
On the Stability of the O-T Linkage in 17-Hydroxyprogesterone (1967) (1)
2595 – INTERACTION IN RATS OF HEXOBARBITAL AND ZOXAZOLAMINE WITH THE SOLVENT GLYCOFUROL (1978) (0)
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques (1963) (0)
FOREIGN COMPOUNDS BY HEPATIC MICROSOMAL ENZYMES (1969) (0)
Evaluation of the effects of cephaloridine on urate excretion in the rat. (1983) (0)
Effects of isoproterenol on the toxicity in rats of compounds eliminated by the kidneys. (1980) (0)
Permeability and intracellular distribution of 4,4'-diacetyl-diphenyl- -urea-bis-guanylhydrazone (ddug) in sensitive and resistant sarcoma 180 cells (s-180) in vitro. Abstr. (1968) (0)
Methods of Biochemical Analysis . vol. 4. David Glick, Ed. Interscience, New York, 1957. ix + 362 pp. Illus. $8.50. (1957) (0)
P-450 mediated catechol estrogen formation in rat heart (1978) (0)
Reductase in the Androgen-Insensitive Pseudohermaphroditic Rat (1971) (0)
Formation of Reactive Metabolites as a Cause of Drug Toxicity (2008) (0)
Uptake, Fate, and Action of Heavy Metals and Organohalogen Compounds in Living Organisms (1975) (0)
Covalently bound metabolites as a measure of dose: the pharmacokinetic aspect. (1983) (0)
Imipramine metabolism: An in vivo and in vitro comparison (1981) (0)
Formation of Reactive Metabolites of Foreign Compounds and their Covalent Binding to Cellular Constituents (2011) (0)
272 – Concluding Remarks (1978) (0)
Biochemical Preparations. Volume 5 (1958) (0)
The Elusive Metabolite—The Reactive Intermediate (1981) (0)
2086 – METABOLISM OF p-180-PHENACETIN: MECHANISM OF FORMATION OF MERCAPTURIC ACID IN HAMSTERS J.A. Hinson (1978) (0)
7A. Inhibitors of steroid metabolic enzymes 252. Spironolactone inhibition of steroid hydroxylation in adrenal and testis (1974) (0)
Methods of Biochemical Analysis . vol. III. David Glick, Ed. Interscience, New York, 1956. 437 pp. Illus. $9.50. (1956) (0)
1028 – ON THE R0LE 0F CYTOCHROME B5, IN CYTOCHROME P-450 SYSTEMS IN LIVER MICROSOMES (1977) (0)
Theoretical Aspects of Drug Interactions of Interest to Drug Research Scientists and Clinicians (1972) (0)
Methods of Biochemical Analysis . vols. 5 and 6. David Glick, Ed. Interscience, New York, 1957; 1958. ix+502 pp. $9.50; ix+358 pp. $8.50. (1958) (0)
AN UNUSUAL METABOLITE OF TESTOSTERONE BY CYTOCHROME P-450 (1987) (0)
Studies of the stoichiometric relationships between the oxidation of drugs and the oxidation of reduced pyridine nucleotides by liver microsomal enzymes. (1971) (0)
1026 – INVESTIGATION OF THE MECHANISM OF DESTRUCTION OF ADRENAL MICROSOMAL CYTOCHROME P-450 BY SPIRONOLACTONE (1978) (0)
SYMPOSIUM ON DRUG METABOLISM: INTRODUCTORY REMARKS (1976) (0)

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