J. R. D. Mitchell
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Most Influential Person Now
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J. R. D. Mitchellbiology Degrees
Biology
#9281
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#12467
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Biochemistry
#1402
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#1526
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Chemistry Biology
J. R. D. Mitchell's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry Stanford University
Why Is J. R. D. Mitchell Influential?
(Suggest an Edit or Addition)J. R. D. Mitchell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. (1974) (2848)
- Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. (1973) (1667)
- Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. (1973) (1443)
- Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. (1973) (1152)
- Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis. (1976) (483)
- Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. (1973) (480)
- Isoniazid-associated hepatitis in 114 patients. (1975) (346)
- Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. (1983) (334)
- Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. (1974) (288)
- Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. (1974) (280)
- Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. (1980) (231)
- Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver. (1988) (230)
- Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. (1978) (219)
- Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat. (1976) (211)
- Role of detoxifying enzymes in bromobenzene-induced liver necrosis. (1973) (201)
- Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury. (1989) (189)
- Molecular basis for several drug-induced nephropathies. (1977) (166)
- Isoniazid hepatoxicity: the relationship between covalent binding and metabolism in vivo. (1980) (164)
- Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals. (2001) (163)
- Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. (1985) (160)
- Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. (1976) (151)
- Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. (1974) (149)
- Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. (1990) (148)
- Bromobenzene metabolism and hepatic necrosis. (1971) (136)
- Drug metabolism as a cause of drug toxicity. (1973) (133)
- Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. (1977) (127)
- Acetylation rates and monthly liver function tests during one year of isoniazid preventive therapy. (1975) (125)
- Age-dependence of hypertensive-normotensive differences in plasma norepinephrine. (1983) (125)
- The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene. (1973) (119)
- Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. (1970) (114)
- Guanethidine and related agents. I. Mechanism of the selective blockade of adrenergic neurons and its antagonism by drugs. (1970) (113)
- The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis. (1980) (108)
- Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress. (1990) (107)
- Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates. (1976) (99)
- Oxidant stress and hepatic necrosis in rats treated with diquat. (1985) (95)
- High-performance liquid chromatography and gas chromatography-mass spectrometry determination of specific lipid peroxidation products in vivo. (1983) (91)
- Hypoxic damage generates reactive oxygen species in isolated perfused rat liver. (1988) (89)
- Alkylation of the liver plasma membrane and inhibition of the Ca2+ ATPase by acetaminophen. (1988) (85)
- Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography. (1977) (85)
- Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines. (1977) (83)
- Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans. (1985) (81)
- Ethanol suppresses hepatic glutathione synthesis in rats in vivo. (1984) (80)
- Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool. (1981) (79)
- Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite. (1976) (77)
- Quantitation of lipid peroxidation products by gas chromatography-mass spectrometry. (1986) (77)
- Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin. (1977) (76)
- Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. (1967) (75)
- The role of biotransformation in chemical-induced liver injury. (1976) (73)
- Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice. (1985) (73)
- Acute pulmonary injury in rats by nitrofurantoin and modification by vitamin E, dietary fat, and oxygen. (2015) (71)
- Metabolic activation: biochemical basis for many drug-induced liver injuries. (1976) (68)
- Biliary excretion of glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress. (1984) (65)
- N-Hydroxylation of phenacetin by hamster liver microsomes. (1976) (59)
- The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats. (1974) (57)
- Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress. (1985) (54)
- Renin-aldosterone profiling in hypertension. (1977) (53)
- Regulation of expression of the lipoprotein lipase gene in brown adipose tissue. (1992) (51)
- Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine. (1978) (50)
- Echocardiographic comparison of black and white hypertensive subjects. (1979) (48)
- Biochemical changes after hepatic injury from toxic doses of acetaminophen or furosemide. (1976) (46)
- Chemical nature of reactive intermediates as determinant of toxicologic responses. (1982) (45)
- ATP-dependent calcium uptake by rat liver plasma membrane vesicles. Effect of alkylating hepatotoxins in vivo. (1985) (45)
- Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man. (1987) (43)
- Plasma norepinephrine concentrations: no differences among normal volunteers and low, high or normal renin hypertensive patients. (1978) (42)
- Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury. (1990) (42)
- Propylbutyldopamine: Hemodynamic Effects in Conscious Dogs, Normal Human Volunteers and Patients with Heart Failure (1983) (41)
- Biochemical changes after hepatic injury by allyl alcohol and N-hydroxy-2-acetylaminofluorene. (1976) (39)
- Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A. (1971) (38)
- Relationship between NADH and NADPH oxidation during drug metabolism. (1973) (38)
- Activation of peripheral dopamine presynaptic receptors lowers blood pressure and heart rate in dogs. (1983) (37)
- Plasma concentrations of propranolol and 4-hydroxypropranolol in man measured by high pressure liquid chromatography. (1979) (36)
- An investigation of the cause of accumulation of verapamil during regular dosing in patients. (1985) (33)
- Role of interferon in prophylaxis of rabies after exposure. (1976) (30)
- Toxicity-related changes in benzene metabolism in vivo. (1977) (28)
- Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension. (1978) (27)
- Enzyme-linked immunosorbent assay with major outer membrane proteins of Brucella melitensis to measure immune response to Brucella species (1986) (27)
- Formation of chemically reactive metabolites of phenacetin and acetaminophen. (1981) (27)
- Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man. (1988) (27)
- Proliferation and differentiation of human myeloid leukemic cells in immunodeficient mice: electron microscopy and cytochemistry. (1984) (26)
- Rhesus diploid rabies vaccine (adsorbed): a new rabies vaccine using FRhL-2 cells. (1985) (26)
- Quantitation of leukotriene B4 in human serum by negative ion gas chromatography-mass spectrometry. (1989) (26)
- Spectrum of dysautonomia in mitral valvular prolapse. (1989) (26)
- Application of chemical ionization mass spectrometry and the twin-ion technique to better define a mechanism in acetylhydrazine toxicity. (1976) (24)
- Evidence for increased membrane permeability of plasmalemmal vesicles from livers of phenobarbital-induced CCl4-intoxicated rats. (1986) (23)
- A placebo-controlled dose-response study of the reactogenicity and immunogenicity of a cold-adapted recombinant A/Victoria/3/75 (H3N2) live influenza virus candidate vaccine in healthy volunteers. (1977) (23)
- Drug metabolism in the production of liver injury. (1975) (22)
- High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma. (1987) (21)
- The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes. (1981) (21)
- Verapamil and norverapamil determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single-dose pharmacokinetic studies. (1984) (20)
- Diquat hepatotoxicity in the Fischer-344 rat: the role of covalent binding to tissue proteins and lipids. (1989) (19)
- Overview of alkylation and peroxidation mechanisms in acute lethal hepatocellular injury by chemically reactive metabolites. (1981) (19)
- Immunization Against Ehrlich's Ascites Carcinoma with X-Irradiated Tumor Cells.∗ (1959) (18)
- Plasma glutathione disulfide as an index of oxidant stress in vivo: effects of carbon tetrachloride, dimethylnitrosamine, nitrofurantoin, metronidazole, doxorubicin and diquat. (1984) (18)
- N-hydroxylation of p-chloroacetanilde in hamsters. (1976) (18)
- Deuterium isotope effects on the metabolism and toxicity of phenacetin in hamsters. (1978) (17)
- Effect of Environmental Temperature on the Response of Mice to Whole-Body Roentgen Radiation (1949) (17)
- No evidence for reactive oxygen damage in ischemia-reflow injury. (1987) (16)
- Rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine. II. Results of clinical studies simulating prophylactic therapy for rabies exposure. (1983) (15)
- Free radicals in vivo. Covalent binding to lipids. (1984) (15)
- Rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine. Results of initial clinical studies of preexposure vaccination. (1982) (15)
- Alkylation and peroxidation injury from chemically reactive metabolites. (1981) (14)
- In vivo regulation of hepatic glutathione synthesis: effects of food deprivation or glutathione depletion by electrophilic compounds. (1981) (13)
- Detection of Toxacara canis Antibodies with the Fluorescent Antibody Technique.∗ (1964) (13)
- Measurement of oxidant stress in vivo. (1990) (13)
- Glutathione disulfide formation and lipid peroxidation during cardiac ischemia and reflow in the dog in vivo. (1989) (12)
- Steady state verapamil tissue distribution in the dog: differing tissue accumulation. (1986) (11)
- Liver membrane calcium transport in diquat-induced oxidative stress in vivo. (1988) (11)
- Propylbutyldopamine. Mechanism of blood pressure lowering in hypertensive patients. (1984) (11)
- Covalent binding: useful index of the formation of chemically reactive drug metabolites. (1975) (10)
- The role of cytochrome b5 in cytochrome P-450 enzymes. (1975) (10)
- Sensitive procedure for detecting residual viable virus in inactivated rabies vaccine. (1971) (10)
- Drug Actions and Interactions: Theoretical Considerations (1975) (8)
- Characterization of a herpes-like virus recovered from Burkitt lymphoma cells(P3-J) and propagated in dog thymus cells. 1. An electron microscope study. (1968) (8)
- Drug-induced liver injury. (1978) (8)
- Proliferation of human malignant hematopoietic cells in immunodeficient mice: suppression by antibody to pluripotent K-562 leukemia cells involves direct cytolysis and effector cells. (1983) (8)
- Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems. (1981) (8)
- Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. (1982) (7)
- Activities of enzymes of glycerolipid synthesis in brown adipose tissue after treatment of rats with the adrenergic agonists BRL 26830A and phenylephrine, after exposure to cold and in streptozotocin-diabetes. (1991) (7)
- The pathophysiological significance of reactive oxygen formation in rat liver. (1991) (6)
- Alkylating toxins and the liver plasma membrane calcium pump/calcium atpase. (1988) (6)
- The redox midpoint potential of haem a in cytochrome-c oxidase is sensitive to extramitochondrial pH (1989) (6)
- Terazosin (Hytrin): cumulative experience of clinical trials in the USA for the treatment of mild to moderate essential hypertension. (1987) (6)
- A study of glycerolphosphate acyltransferase in rat liver mitochondria-submitochondrial localization and some properties of the solubilized enzyme. (1994) (5)
- Isolation of a virus from Burkitt lymphoma cells. (1967) (5)
- Progress in hepatology. Metabolic activation of drugs to toxic substances. (1975) (5)
- 268 – FORMATION OF CHEMICALLY REACTIVE METABOLITES FROM DRUGS (1978) (4)
- Application of Chemical Ionization Ms and the Twin-Ion Technique in the Analysis of Reactive Intermediates in Drug Metabolism (1977) (4)
- The response of brown adipose tissue mitochondrial glycerolphosphate acyltransferase to cold-exposure in hypothyroidism, after adrenalectomy and after treatment with cycloheximide. (1994) (3)
- The role of metabolic activation for drug-induced liver injuries. (1977) (3)
- Absence of morphological, chromosomal and antigenic changes in the K-562 cell line growing as localized or disseminated tumours in nude mice. (1982) (2)
- IMPORTANCE OF DOSE-THRESHOLD FOR DRUG-INDUCED TISSUE LESIONS (1976) (1)
- Metastasizing mammary tumors. Spontaneous mammary tumors in asplenic mice heterozygous for athymia. (1982) (1)
- Macromolecular binding in assessing drug and chemical-induced tissue lesions. (1977) (1)
- Effects of x-irradiated tumor cells on spontaneous mammary tumor recurrences in C3H mice. (1962) (1)
- Relevance of lipids to heterotransplantation of human malignancies. (1982) (1)
- Suppression of metastases of heterotransplanted human cells by an antibody. Abstr. (1981) (1)
- Identification of a Burkitt-cell virus. (1969) (1)
- Tissue selective toxicity: Introduction (1984) (0)
- Sensitive Procedure for Detecting Residual Viable Virus in Inactivated Rabies Vaccine (1971) (0)
- Lipid metabolism in the brown adipose tissue of the hibernating and the cold acclimated hamster (1989) (0)
- The use of stable isotopes to better define toxic metabolic pathways of p-hydroxyacetanilide (acetaminophen) and p-ethoxyacetanilide (phenacetin) (1978) (0)
- Characterization of a herpes-like virus recovred from Burkitt lymphoma cells(P3-J) and propagated in dog thymus cells. 1. An electron microscope study. (1968) (0)
- 416 – INCREASES IN SEVERAL DRUG-INDUCED RENAL LESIONS AFTER HIGH FAT DIETS DEFICIENT IN OR REPLETED WITH VITAMIN E (1978) (0)
- 2241 – USE OF STABLE ISOTOPES IN TOXICOLOGIC STUDIES OF CHEMICALLY REACTIVE DRUG METABOLITES (1978) (0)
- Effects of treatment of one tumor transplant upon subsequent tumor transplants in mice. (1962) (0)
- Age associated regulation of dissemination of human leukemia cells in nude mice. Abstr. (1982) (0)
- Evidence for increased permeability of rat liver plasma membrane vesicles after CCl/sub 4/ in vivo (1986) (0)
- Sensitive Procedure forDetecting Residual Viable Virus inInactivated Rabies Vaccine (1971) (0)
- Growth of ascites tumors in mice injected with x-irradiated cells by different routes and in different doses. (1961) (0)
- 268 – FORMATION OF CHEMICALLY REACTIVE METABOLITES FROM DRUGS (1978) (0)
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