J. Silvio Gutkind

J. Silvio Gutkind's AcademicInfluence.com Rankings

J. Silvio Gutkind

Biology

#3754

World Rank

#5696

Historical Rank

Cell Biology

#81

World Rank

#86

Historical Rank

Molecular Biology

#254

World Rank

#258

Historical Rank

Neuroscience

#364

World Rank

#381

Historical Rank

biology Degrees

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Biology

J. Silvio Gutkind's Degrees

PhD Molecular Biology University of California, San Diego
Masters Biochemistry University of California, San Diego
Bachelors Biochemistry University of California, San Diego

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J. Silvio Gutkind's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway (1995) (1695)
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate (1996) (1485)
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules (1995) (1276)
G-protein-coupled receptors and cancer (2007) (1242)
G-protein-coupled receptors and signaling networks: emerging paradigms. (2001) (1030)
Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis (2005) (920)
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator (1998) (873)
VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin (2006) (846)
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors (1996) (812)
The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades* (1998) (799)
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product (1997) (796)
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. (2009) (778)
Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits (1994) (763)
Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ (1997) (720)
Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging (2007) (719)
Cbl-b regulates the CD28 dependence of T-cell activation (2000) (620)
Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. (2006) (614)
G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension (2008) (563)
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. (1996) (514)
Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. (2009) (469)
Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. (2010) (456)
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer (2013) (443)
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. (2014) (439)
MAP kinases and the control of nuclear events (2007) (432)
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α (2000) (404)
A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho* (1999) (402)
Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. (2008) (380)
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. (2003) (379)
Dysregulated molecular networks in head and neck carcinogenesis. (2009) (375)
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. (2002) (369)
Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway (1996) (364)
Activation of Akt/Protein Kinase B by G Protein-coupled Receptors (1998) (364)
Signaling from E-cadherins to the MAPK Pathway by the Recruitment and Activation of Epidermal Growth Factor Receptors upon Cell-Cell Contact Formation* (2000) (357)
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. (2009) (355)
CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex* (2009) (354)
The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth* (2001) (336)
Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. (2010) (316)
Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays (2000) (305)
Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis (2010) (301)
Proteomic profiling of the cancer microenvironment by antibody arrays (2001) (288)
A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. (2000) (279)
Illuminating G-Protein-Coupling Selectivity of GPCRs (2019) (278)
Cell growth control by G protein-coupled receptors: from signal transduction to signal integration (1998) (278)
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. (1991) (276)
Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors (2000) (270)
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (2003) (266)
Regulation of the Transcriptional Activity of c-Fos by ERK (2005) (264)
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation (2008) (262)
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. (2005) (253)
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? (2001) (251)
Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho (2000) (247)
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. (2012) (242)
Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B (2004) (240)
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. (2001) (235)
Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions (1999) (234)
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. (2005) (232)
Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase (1995) (232)
A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH2-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5 (1999) (231)
Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway (*) (1996) (231)
Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative (2007) (228)
The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. (1997) (226)
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. (1994) (220)
Novel insights into G protein and G protein-coupled receptor signaling in cancer. (2014) (218)
Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors Leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF* (2002) (217)
Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. (2011) (213)
Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. (2006) (212)
A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt* (2000) (211)
Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK) (1995) (208)
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. (2010) (202)
The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. (2004) (201)
Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation (2000) (199)
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. (1990) (198)
Binding-Induced Folding of a Natively Unstructured Transcription Factor (2008) (198)
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. (2006) (195)
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer (2008) (191)
Functional roles of Akt signaling in mouse skin tumorigenesis (2002) (190)
Phosphorylation of c-Fos by Members of the p38 MAPK Family (2005) (189)
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. (2000) (188)
Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma (2004) (187)
Viral hijacking of G-protein-coupled-receptor signalling networks (2004) (184)
Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. (2006) (181)
MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D* (2007) (179)
The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG (2002) (176)
Rac1 Function Is Required for Src-induced Transformation (2003) (173)
MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. (2001) (173)
IL‐4 activates a distinct signal transduction cascade from IL‐3 in factor‐dependent myeloid cells. (1992) (172)
Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. (2012) (171)
A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. (1993) (171)
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. (1993) (171)
mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. (2002) (170)
Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression (2008) (170)
mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas (2012) (168)
Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. (1996) (166)
Erratum: G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator (1998) (165)
Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models (2010) (165)
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB (2002) (162)
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies (2014) (161)
Calibration of 125I-polymer standards with 125I-brain paste standards for use in quantitative receptor autoradiography (1989) (159)
Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras (2010) (158)
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. (2004) (158)
Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles. (2011) (156)
The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells (1996) (156)
Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway (2005) (155)
Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3 (2011) (153)
The Gα13-Rho Signaling Axis Is Required for SDF-1-induced Migration through CXCR4* (2006) (152)
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells (1992) (152)
Phosphorylation of the Carboxyl-Terminal Transactivation Domain of c-Fos by Extracellular Signal-Regulated Kinase Mediates the Transcriptional Activation of AP-1 and Cellular Transformation Induced by Platelet-Derived Growth Factor (2003) (152)
Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. (2010) (151)
Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. (2011) (151)
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway (2001) (150)
Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK (2017) (149)
Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation (2012) (149)
Potent Activation of RhoA by Gαq and Gq-coupled Receptors* (2002) (147)
Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer (2011) (146)
P-Rex1 Links Mammalian Target of Rapamycin Signaling to Rac Activation and Cell Migration* (2007) (146)
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. (2000) (145)
A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells (2011) (140)
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret (1998) (139)
Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. (1988) (137)
Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation (2012) (137)
Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer. (2009) (136)
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock (2015) (136)
Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis (2004) (135)
Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model (2009) (134)
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. (2019) (133)
Regulation of c-myc expression by PDGF through Rho GTPases (2001) (132)
Regulation of G Protein-linked Guanine Nucleotide Exchange Factors for Rho, PDZ-RhoGEF, and LARG by Tyrosine Phosphorylation (2002) (132)
Loss of PTEN expression leading to high Akt activation in human multiple myelomas. (2000) (131)
Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway* (1997) (131)
Modulation of canonical Wnt signaling by the extracellular matrix component biglycan (2011) (130)
Plexin-B1 Utilizes RhoA and Rho Kinase to Promote the Integrin-dependent Activation of Akt and ERK and Endothelial Cell Motility* (2007) (127)
A Human Suppressor of c-Jun N-terminal Kinase 1 Activation by Tumor Necrosis Factor α* (1997) (125)
Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions (2012) (121)
Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis (2015) (119)
Regulation of p73 by c-Abl through the p38 MAP kinase pathway (2002) (115)
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. (2013) (114)
Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential (2004) (114)
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6 (2010) (112)
PTEN deficiency contributes to the development and progression of head and neck cancer. (2013) (111)
Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. (2016) (110)
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. (1991) (108)
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. (2017) (108)
Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. (2013) (108)
p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. (2012) (107)
Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. (2008) (106)
The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. (2004) (105)
Down-regulation of CXCL5 inhibits squamous carcinogenesis. (2006) (105)
Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model (2012) (105)
PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells (2002) (105)
A role for p38 MAPK in head and neck cancer cell growth and tumor‐induced angiogenesis and lymphangiogenesis (2014) (105)
Assembly and patterning of the vascular network of the vertebrate hindbrain (2011) (103)
Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets (1990) (103)
Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy (2019) (102)
Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms. (2009) (100)
Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation* (2003) (100)
mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations (2014) (100)
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor (2018) (99)
Selective Activation of Effector Pathways by Brain-specific G Protein β5* (1996) (99)
Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. (2008) (99)
A Common Requirement for the Catalytic Activity and Both SH2 Domains of SHP-2 in Mitogen-activated Protein (MAP) Kinase Activation by the ErbB Family of Receptors (1998) (98)
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase (2010) (98)
VE-cadherin and claudin-5: it takes two to tango (2008) (97)
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction (1991) (96)
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. (2007) (96)
Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6 (2010) (96)
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. (2006) (96)
The p53 tumor suppressor targets a novel regulator of G protein signaling. (1997) (95)
Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. (1994) (93)
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation (1997) (93)
Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility (2008) (93)
Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. (1989) (93)
Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12 (2005) (92)
Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway. (2000) (92)
Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways (2002) (91)
Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays (2004) (90)
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from Gα12/13 and Gα11/q* (2008) (90)
Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes (1994) (90)
Phosphoinositide 3-Kinase γ Is a Mediator of Gβγ-dependent Jun Kinase Activation* (1998) (90)
Rac1 Is Required for Epithelial Stem Cell Function during Dermal and Oral Mucosal Wound Healing but Not for Tissue Homeostasis in Mice (2010) (89)
Faculty Opinions recommendation of Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. (2008) (89)
A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. (2010) (88)
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. (2009) (88)
Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades (1999) (88)
LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma (2016) (88)
Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. (2005) (87)
P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor (2004) (87)
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma (2003) (86)
Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin. (2008) (86)
Signals and Receptors. (2016) (86)
Robo4 Signaling in Endothelial Cells Implies Attraction Guidance Mechanisms* (2006) (86)
Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis (2006) (86)
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. (2001) (86)
Angiotensin II binding sites in the conduction system of rat hearts. (1987) (85)
PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma (2015) (84)
The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. (2009) (84)
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. (2009) (84)
Chemical Carcinogenesis Models for Evaluating Molecular-Targeted Prevention and Treatment of Oral Cancer (2009) (83)
E-cadherin and Hakai: signalling, remodeling or destruction? (2002) (83)
Complementary Roles of Intracellular and Pericellular Collagen Degradation Pathways In Vivo (2007) (82)
Biology of advanced uveal melanoma and next steps for clinical therapeutics (2014) (79)
Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries. (2000) (79)
Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The β-Catenin Connection (2006) (79)
Global gene expression profiles of human head and neck squamous carcinoma cell lines (2004) (78)
Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. (1998) (78)
Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. (2012) (78)
Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor* (1999) (78)
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4 (2019) (77)
NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell (2016) (76)
Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature* (2008) (75)
Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009) (75)
Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. (2012) (74)
A Role for a CXCR2/Phosphatidylinositol 3-Kinase γ Signaling Axis in Acute and Chronic Vascular Permeability (2009) (74)
Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (2001) (74)
CKA, a Novel Multidomain Protein, Regulates the JUN N-Terminal Kinase Signal Transduction Pathway in Drosophila (2002) (74)
Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? (2004) (73)
Direct Interaction of p21-Activated Kinase 4 with PDZ-RhoGEF, a G Protein-linked Rho Guanine Exchange Factor* (2004) (72)
Role for EPS8 in squamous carcinogenesis. (2009) (72)
Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. (2012) (71)
Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats. (1988) (71)
Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2*♦ (2009) (71)
Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics (2019) (70)
Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. (2011) (70)
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets (2010) (70)
p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons (2004) (70)
An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia (2008) (70)
Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions (2008) (70)
Engineered Mesenchymal Stem Cells with Enhanced Tropism and Paracrine Secretion of Cytokines and Growth Factors to Treat Traumatic Brain Injury (2015) (69)
The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma (2010) (69)
B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade (2020) (69)
Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk (2006) (68)
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. (1997) (67)
Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. (2016) (67)
Role of Mitogen-activated Protein Kinases and c-Jun/AP-1 trans-Activating Activity in the Regulation of Protease mRNAs and the Malignant Phenotype in NIH 3T3 Fibroblasts* (1999) (66)
Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. (2013) (66)
Inactivating Mutations in GNA13 and RHOA in Burkitt’s Lymphoma and Diffuse Large B cell Lymphoma: A Tumor Suppressor Function for the Gα13/RhoA Axis in B Cells (2015) (66)
Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer (2013) (65)
Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis (2013) (65)
Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway (2014) (65)
Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients. (2012) (64)
Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation. (1991) (64)
Signaling circuitries controlling stem cell fate: to be or not to be. (2011) (64)
PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. (2011) (64)
Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis. (2003) (63)
Targeted Therapeutic Nanotubes Influence the Viscoelasticity of Cancer Cells to Overcome Drug Resistance (2014) (63)
Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation (2012) (62)
A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes (2014) (62)
The Platelet-derived Growth Factor Controls c-myc Expression through a JNK- and AP-1-dependent Signaling Pathway* (2003) (61)
The NOTCH4–HEY1 Pathway Induces Epithelial–Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma (2017) (60)
Reciprocal negative regulation between S100A7/psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity (2008) (60)
Direct targeting of Gαq and Gα11 oncoproteins in cancer cells (2019) (60)
IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells (2020) (59)
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). (2002) (59)
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. (2007) (58)
Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis (2014) (58)
Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)* (2013) (58)
Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial (2018) (58)
Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis. (1992) (57)
SDF‐1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis (2015) (57)
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells (2007) (56)
Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. (2013) (56)
Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes (2003) (55)
Phosphatidylinositol-4-phosphate 5-Kinase and GEP100/Brag2 Protein Mediate Antiangiogenic Signaling by Semaphorin 3E-Plexin-D1 through Arf6 Protein* (2011) (55)
Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C (2001) (54)
Insulin-Like Growth Factor I Synergizes with Interleukin 4 for Hematopoietic Cell Proliferation Independent of Insulin Receptor Substrate Expression (1999) (54)
GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling. (2018) (53)
PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation* (2013) (53)
Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition. (1995) (52)
Signaling networks and cell cycle control : the molecular basis of cancer and other diseases (2000) (52)
A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. (2008) (52)
Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation (1998) (51)
Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma (2016) (51)
EPS8 upregulates FOXM1 expression, enhancing cell growth and motility. (2010) (50)
Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. (2011) (50)
Signaling from G Protein-coupled Receptors to the c-jun Promoter Involves the MEF2 Transcription Factor (1997) (50)
Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase. (2000) (50)
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers (2020) (48)
Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate. (1992) (48)
Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models (2014) (48)
Identification of distinct populations of PI-3 kinase activity following T-cell activation. (1992) (47)
Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 (2015) (46)
Scaffold proteins dictate Rho GTPase-signaling specificity. (2005) (46)
Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis. (2006) (46)
Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. (2006) (46)
Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development. (1990) (46)
Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet-Printed Gold Nanoparticle Arrays (2013) (45)
Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas (2020) (45)
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6 (2008) (45)
The Rho Family GTPase Cdc42 Regulates the Activation of Ras/MAP Kinase by the Exchange Factor Ras-GRF* (2000) (45)
SPECs, Small Binding Proteins for Cdc42* (2000) (44)
Receptor Tyrosine Kinases Activate Canonical WNT/?-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct Beta-Catenin Phosphorylation (2012) (43)
Epidermal Growth Factor Receptor-independent Constitutive Activation of STAT 3 in Head and Neck Squamous Cell Carcinoma Is Mediated by the Autocrine / Paracrine Stimulation of the Interleukin 6 / gp 130 Cytokine System (2003) (43)
Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer (2016) (43)
How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study. (2009) (42)
Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance. (2011) (42)
CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. (2012) (42)
mTOR Inhibitors and its Role in the Treatment of Head and Neck Squamous Cell Carcinoma (2012) (42)
LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes (2014) (42)
Nano Delivers Big: Designing Molecular Missiles for Cancer Therapeutics (2011) (41)
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies (2016) (41)
Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells. (1996) (41)
Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo (2016) (41)
4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. (2019) (40)
Laminin‐γ2 overexpression in head‐and‐neck squamous cell carcinoma (2002) (40)
Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. (2016) (40)
Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling (1994) (39)
The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor* (1997) (39)
Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. (2015) (39)
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. (2002) (39)
Novel Molecular Mediators in the Pathway Connecting G-protein-coupled Receptors to MAP Kinase Cascades (1999) (39)
Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project. (2000) (39)
Atrial natriuretic peptide receptors in sympathetic ganglia: biochemical response and alterations in genetically hypertensive rats. (1987) (38)
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. (1996) (38)
Future directions and treatment strategies for head and neck squamous cell carcinomas. (2012) (37)
Galpha12 requires acylation for its transforming activity. (1998) (37)
Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C. (1993) (37)
Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. (2013) (36)
Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes. (1994) (36)
DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. (2013) (36)
Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways (1991) (36)
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. (2006) (35)
Combining Portable Raman Probes with Nanotubes for Theranostic Applications (2011) (35)
Specific angiotensin II binding sites in the rat stellate and superior cervical ganglia (1987) (35)
HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers (2020) (35)
WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13 (2016) (35)
Arrestins as rheostats of GPCR signalling (2018) (34)
Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling (2012) (34)
Signal transduction and human disease (2003) (34)
Exploiting the mTOR paradox for disease prevention (2012) (34)
Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance (2017) (34)
The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-κB activity in drug-sensitive MCF-7 cells (2005) (33)
PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells (1997) (33)
Potent transforming activity of the small GTP‐binding protein Rit in NIH 3T3 cells: evidence for a role of a p38γ‐dependent signaling pathway (2002) (33)
Cholecystokinin Receptor Antagonist Halts Progression of Pancreatic Cancer Precursor Lesions and Fibrosis in Mice (2014) (33)
Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation. (2006) (33)
The Biology of Tobacco and Nicotine: Bench to Bedside (2005) (32)
Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression. (2005) (31)
Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation (1989) (31)
mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. (2016) (31)
TGFβ Receptor I Conditional Knockout Mice Develop Spontaneous Squamous Cell Carcinoma (2007) (31)
The Kaposi ’ s Sarcoma-associated Herpes Virus G Protein-coupled Receptor UpRegulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p 38 Pathways Acting on Hypoxia-inducible Factor 1 a 1 (2000) (31)
IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis (2013) (31)
Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor (2011) (30)
A C-terminal Mutant of the G Protein β Subunit Deficient in the Activation of Phospholipase C-β* (1996) (30)
A new G(q)-initiated MAPK signaling pathway in the heart. (2009) (29)
Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation (2014) (29)
Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma (2014) (29)
Tensin can induce JNK and p38 activation. (2000) (29)
Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis (2019) (29)
Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis (2014) (28)
The P34G Mutation Reduces the Transforming Activity of K-Ras and N-Ras in NIH 3T3 Cells but Not of H-Ras* (2004) (28)
Massively Parallel Sequencing Reveals an Accumulation of De Novo Mutations and an Activating Mutation of LPAR1 in a Patient with Metastatic Neuroblastoma (2013) (28)
The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors (1998) (28)
Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer. (2019) (28)
Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation. (1998) (28)
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. (2014) (27)
A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. (2017) (27)
The Gα12/13 Family of Heterotrimeric G Proteins and the Small GTPase RhoA Link the Kaposi Sarcoma-associated Herpes Virus G Protein-coupled Receptor to Heme Oxygenase-1 Expression and Tumorigenesis* (2007) (27)
Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration (2013) (27)
Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity. (2013) (27)
Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes. (2009) (27)
G protein-regulated endocytic trafficking of adenylyl cyclase type 9 (2020) (27)
Metformin inhibits progression of Head and Neck Squamous Cell Carcinoma by acting Directly on Carcinoma Initiating Cells. (2019) (26)
Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury. (2015) (26)
Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells. (1995) (26)
1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. (2010) (26)
Dual Effect of b-Adrenergic Receptors on Mitogen-activated Protein Kinase (1995) (26)
Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells (2016) (25)
TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 (2013) (25)
Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation. (2006) (25)
Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer (2020) (24)
Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. (2004) (24)
Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation (2020) (24)
Control of regulatory T cell and Th17 cell differentiation by inhibitory helix-loop-helix protein Id3 (2010) (24)
Longitudinal Imaging Studies of Tumor Microenvironment in Mice Treated with the mTOR Inhibitor Rapamycin (2012) (24)
Neuronal Nuclear Organization Is Controlled by Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor-1 (2006) (23)
Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer (2021) (23)
Signaling Networks and Cell Cycle Control (2000) (23)
Activation of the mTOR Pathway in Primary Medullary Thyroid Carcinoma and Lymph Node Metastases (2012) (23)
A nonsynonymous single‐nucleotide polymorphism in the PDZ‐Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans (2006) (23)
An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation. (2015) (23)
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins (2018) (23)
Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. (1994) (23)
The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy. (2014) (23)
Regulation of brain atrial natriuretic peptide and angiotensin receptors: quantitative autoradiographic studies. (1989) (22)
Enalapril decreases angiotensin II receptors in subfornical organ of SHR. (1989) (22)
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma (2021) (22)
Mitogen-Activated Protein Kinases Promote WNT/beta-CateninSignaling via Phosphorylation of LRP6 (2011) (22)
The homozygous CX3CR1-M280 mutation impairs human monocyte survival. (2018) (22)
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway (2003) (22)
SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands. (2019) (22)
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity (2021) (22)
Induction of apoptosis in head‐and‐neck squamous carcinoma cells by γ‐irradiation and bleomycin is p53‐independent (2000) (21)
Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene (2014) (21)
Identification and Characterization of a Novel Ste20/Germinal Center Kinase-related Kinase, Polyploidy-associated Protein Kinase* (2003) (21)
Deletion of the COOH Terminus Converts the ST5 p70 Protein from an Inhibitor of RAS Signaling to an Activator with Transforming Activity in NIH-3T3 Cells* (2000) (21)
Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. (2004) (21)
Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells (2014) (21)
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes (1991) (21)
Isoproterenol inhibits fibroblast growth factor-2-induced growth of renal epithelial cells (2000) (20)
The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades. (1997) (20)
Head and Neck Cancer: Emerging Perspectives (2003) (20)
Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray. (2020) (20)
Agonist-induced Ca2+ Sensitization in Smooth Muscle (2013) (20)
The pathway linking small GTP-binding proteins of the Rho family to cytoskeletal components and novel signaling kinase cascades (1996) (20)
HPV16 E5 Mediates Resistance to PD-L1 Blockade and can be targeted with Rimantadine in Head and Neck Cancer. (2019) (20)
Angiotensin II and Basic Fibroblast Growth Factor Mitogenic Pathways in Human Fetal Mesangial Cells (2000) (19)
Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects (2011) (19)
Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter. (2016) (19)
Decreased angiotensin II receptors in subfornical organ of spontaneously hypertensive rats after chronic antihypertensive treatment with enalapril. (1990) (19)
Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance (2019) (19)
Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2019) (19)
Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions (2021) (19)
Calcium signaling induces a partial EMT (2021) (19)
Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. (2010) (19)
Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation (2000) (19)
Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis (2014) (19)
Chimeric Gαi2/Gα13 Proteins Reveal the Structural Requirements for the Binding and Activation of the RGS-like (RGL)-containing Rho Guanine Nucleotide Exchange Factors (GEFs) by Gα13* (2004) (19)
Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer (2016) (18)
Role of GRB2‐associated binder 1 in epidermal growth factor receptor‐induced signaling in head and neck squamous cell carcinoma (2013) (18)
Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential (2019) (18)
Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology. (2005) (18)
cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits (2018) (17)
Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression (2021) (17)
Nuclear mapping of nanodrug delivery systems in dynamic cellular environments. (2012) (17)
Muscarinic receptors promote castration resistant growth of prostate cancer through a FAK-YAP signaling axis (2020) (17)
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers (2016) (17)
Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer (2020) (17)
Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold (2019) (17)
Role for EPS 8 in squamous carcinogenesis (2009) (16)
Diverse biologic properties imparted by the c-fgr proto-oncogene. (1992) (16)
The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors. (1994) (16)
Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαq and Gα12/13 Families of Heterotrimeric G Proteins (2000) (15)
Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors. (2007) (15)
Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. (2009) (15)
Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis (2021) (15)
Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. (2003) (15)
Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes (1998) (14)
PRECOG: PREdicting COupling probabilities of G-protein coupled receptors (2019) (14)
Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake. (2015) (14)
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling (2021) (14)
Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC (2022) (14)
Insights into β2‐adrenergic receptor binding from structures of the N‐terminal lobe of ARRDC3 (2014) (14)
Oncotargeting G proteins: The Hippo in the room (2014) (14)
THE KSHV/HHV 8 G PROTEIN COUPLED RECEPTOR IS A VIRAL ONCOGENE AND ANGIOGENESIS ACTIVATOR (1998) (13)
Semaphorin 4 D / Plexin-B 1 Induces Endothelial Cell Migration through the Activation of PYK 2 , Src , and the Phosphatidylinositol 3-Kinase – Akt Pathway (2005) (13)
MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements (2011) (13)
Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation. (2009) (12)
Interpretation of cancer mutations using a multiscale map of protein systems (2021) (12)
Regulation of angiotensin II binding sites in the subfornical organ and other rat brain nuclei after water deprivation (1987) (12)
A phase I study of everolimus in combination with cetuximab and cisplatin as first-line therapy in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). (2012) (12)
Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways. (2013) (12)
Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma (2020) (12)
MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells (2015) (11)
Cellular systems for studying human oral squamous cell carcinomas. (2011) (11)
The Kaposi’s Sarcoma-associated Herpes Virus G Protein-coupled Receptor Up- Regulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p38 Pathways Acting on Hypoxia-inducible Factor 1a (2000) (11)
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 (2021) (11)
Oral and pharyngeal epithelial keratinocyte culture. (2013) (11)
PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. (1997) (11)
Receptor Tyrosine Kinases Activate Canonical WNT/ b Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct b -Catenin Phosphorylation (2012) (10)
Mitogen-Activated Protein Kinase Family (2004) (10)
Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. (2020) (10)
Unleashing Immunotherapy by Targeting Cancer Stem Cells. (2020) (10)
PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells. (2016) (10)
Exploiting PI 3 K / mTOR signaling to accelerate epithelial wound healing (2013) (10)
Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C REGULATION OF CELL PROLIFERATION AND SURVIVAL* (2001) (10)
A Molecular Crosstalk between E-cadherin and EGFR Signaling Networks (2008) (10)
Levels of sirolimus in saliva and blood following mouthwash application. (2014) (10)
mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity (2020) (9)
E1a is an exogenous in vivo tumour suppressor. (2017) (9)
Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats. (1987) (9)
A pilot, single arm, prospective trial using neoadjuvant rapamycin prior to definitive therapy in head and neck squamous cell carcinoma. (2015) (9)
RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development (2008) (9)
Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes (2017) (8)
Activation of MAPKs by G protein-coupled receptors. (2004) (8)
Genetic variants affecting equivalent protein family positions reflect human diversity (2017) (8)
Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: A case report (2015) (8)
Signaling by G protein coupled receptors and G proteins: a perspective (2001) (8)
Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling (2018) (8)
Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. (2013) (8)
Alteration of atrial natriuretic peptide binding sites in spontaneously hypertensive rats. (1988) (8)
Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application (2015) (8)
Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing (2020) (7)
[The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins]. (2012) (7)
Interaction between β2- and α2-adrenoceptor responses in the vascular system: effect of clenbuterol (1986) (7)
Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes. (2019) (7)
Interactions of protein kinase CK2 subunits. (1999) (7)
Keeping the epidermal stem cell niche in shape. (2010) (7)
Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes (2021) (7)
A new twist for the tumour suppressor hamartin (2000) (7)
Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer (2012) (7)
Correction: Rigiracciolo, D.C., et al., IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells 2020, 9, 1010 (2020) (7)
Phase II trial of everolimus in patients with previously treated recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). (2012) (6)
Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs. (2022) (6)
Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: evidence for a PKC and MAP kinase independent pathway. (1998) (6)
Expression of GNA12 and its role in oral cancer (2011) (6)
The Next Frontier: Head and Neck Cancer Immunoprevention (2017) (6)
The Wnt/β-catenin Signaling Circuitry in Head and Neck Cancer (2014) (5)
Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The B -Catenin Connection (2006) (5)
Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13. (2004) (5)
Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components. (2017) (5)
Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis (2020) (5)
P-Rex1 links mTOR signaling to Rac activation and cell migration (2007) (5)
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC) (2022) (5)
Further Evidence of Interaction Between Vasodilator β2- and Vasoconstrictor α2-Adrenoceptor–Mediated Responses in Maintaining Vascular Tone in Anesthetized Rats (1989) (5)
The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins. (1996) (5)
Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray. (2006) (5)
Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy (2022) (5)
PIK3CA mutations in colorectal and breast cancer: impact on oncogenesis and response to nonsteroidal anti-inflammatory drugs (2019) (5)
Gαs directly drives PDZ-RhoGEF signaling to Cdc42 (2020) (5)
The PH domain of Ras-GAP is sufficient forin Vitro binding toβγ subunits of heterotrimeric G proteins (1996) (4)
Development of a yeast-based system to identify new hBRAFV600E functional interactors (2018) (4)
Effects of clenbuterol treatment on the responses to vasodilators in urethane‐anaesthetized rats (1990) (4)
Chapter 6 Kaposi's Sarcoma Virally Encoded, G‐Protein–Coupled Receptor (2009) (4)
The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress (2020) (4)
Differential Inhibitor of Gβγ Signaling to AKT and ERK Derived from Phosducin-like Protein (2009) (4)
Autoradiographic quantification of vasoactive intestinal peptide binding sites in sections from human blood mononuclear cell pellets. (1988) (4)
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer (2022) (4)
Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats (1988) (4)
The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities (1989) (4)
The Genomic Characterization of Head and Neck Squamous Cell Carcinomas (2016) (4)
Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes (2019) (4)
Multi-Institutional Randomized Double-Blind Phase II Trial of Everolimus vs. Placebo as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN) (2020) (4)
Regulation of mitogen-activated protein kinases by G-protein-coupled receptors. (2002) (4)
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential. (2019) (3)
Cardiovascular effects of alpha-adrenergic drugs: Differences between clonidine and guanabenz (1986) (3)
Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats. (1989) (3)
Characterization of β-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography (1988) (3)
Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives are Potent and Selective σ1 Ligands. (1994) (3)
Single-walled carbon-nanotube forest immunosensor for amplified detection of cancer biomarkers (2006) (3)
Targeting the mTOR Signaling Circuitry in Head and Neck Cancer (2017) (3)
Different pharmacological interaction of clonidine and guanabenz with antidepressive drugs. (1987) (3)
Sonic Hedgehog in SCLC (2015) (3)
Gαs Directly Drives PDZ‐RhoGEF Signaling to Cdc42 (2020) (3)
Ataxia telangiectasia mutated nuclear localization in head and neck cancer cells is PPP2R2B-dependent (2010) (3)
Interaction between beta 2- and alpha 2-adrenoceptor responses in the vascular system: effect of clenbuterol. (1986) (2)
Emerging Cancer Biomarkers for HNSCC Detection and Therapeutic Intervention (2017) (2)
The homozygous CX 3 CR 1M 280 mutation impairs human monocyte survival (2018) (2)
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations (2022) (2)
Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs (2021) (2)
Pressor response induced by clenbuterol treatment in immobilized normotensive rats. (1989) (2)
Meeting Report—The NIDCR 2nd Salivary Gland Tumor Meeting, November 2008 (2009) (2)
GNAS‐PKA Oncosignaling Network in Colorectal Cancer (2018) (2)
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing GPCR-initiated mitogenic signals (2013) (2)
Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia (1984) (2)
Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies (2011) (2)
Molecular Mechanisms of Cancer (2003) (2)
Activation of GPCR-Gαi signaling increases keratinocyte proliferation and reduces differentiation, leading to epidermal hyperplasia. (2019) (2)
1395 Unique transcriptional signature primes oral mucosa for rapid wound healing in humans (2018) (2)
CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NF through the CBM Complex (2020) (1)
Abstract 968: Targeting FAK inhibits YAP-dependent tumor growth in uveal melanoma (2018) (1)
Challenges and Emerging Opportunities for Targeting mTOR in Cancer. (2022) (1)
Targeting mTOR in Head and Neck Cancer—Response (2019) (1)
A phase I dose-finding study of metformin in combination with concurrent cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma. (2018) (1)
PRK AND ROCK ARE REQUIRED FOR THROMBIN-INDUCED ENDOTHELIAL CELL PERMEABILITY DOWNSTREAM FROM Gα12/13 and Gα11/q (2008) (1)
Abstract 1425: Synergistic antitumor efficacy of the dual RAF/MEK inhibitor VS-6766 with FAK inhibition for treatment of RAS-dependent solid tumors (2021) (1)
THE FOLDING AND BINDING PATHWAY OF THE TRANSCRIPTION FACTOR CREB TO CBP (2007) (1)
Cancer Therapy : Preclinical Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically De fi ned Head and Neck Squamous Cell Carcinoma Mouse Model (2012) (1)
Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary (2004) (1)
Endocannabinoids as emerging suppressors of angiogenesis and breast tumor growth and metastatic spreading ” (2008) (1)
Cryo-electron microscopy structure and analysis of the P-Rex1-G-Beta-Gamma signaling scaffold (2019) (1)
Abstract LB-7: HPV-associated HNSCC: Widespread mTOR pathway activity and preclinical evaluation of mTOR inhibitors rapamycin and RAD-001 (2011) (1)
1 Interaction between FGFR-2 , STAT 5 and progesterone receptors in breast cancer (2011) (1)
Therapeutics , Targets , and Chemical Biology p 21-Activated Kinase 1 Is Required for Ef fi cient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model (2012) (1)
Identifying novel molecular vulnerabilities to PTK2/FAK inhibition in G α q‐driven uveal melanoma using a kinome‐wide CRISPR/Cas9 screen (2019) (1)
Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2018) (1)
Correction to: mTOR co-targeting strategies for head and neck cancer therapy (2018) (1)
Antitumor activity of tipifarnib and PI3K pathway inhibitors in HRAS-associated HNSCC. (2020) (1)
Role in the AP-1 response to UV (2005) (1)
HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer (2022) (1)
Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1 (2022) (1)
Faculty Opinions recommendation of Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. (2005) (1)
Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models (2014) (1)
Somatic 9p24.1 alterations in HPV– head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity (2022) (1)
MKP 1 mediates chemosensitizer effects of E 1 a in response to cisplatin in non-small cell lung carcinoma cells (2017) (1)
Signaling from G-Protein-Coupled Receptors to the Nucleus (2000) (1)
O127. EPS8 in squamous carcinogenesis (2009) (1)
G Protein-Coupled Receptors: RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling (2010) (1)
Rab 25 in head and neck cancer metastasis 1 Rab 25 regulates invasion and metastasis in head and neck cancer (2012) (1)
Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling (2011) (1)
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors (2023) (1)
GPCRs in head and neck squamous cell carcinoma (2020) (1)
G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation (2010) (1)
Abstract 4985: M4OC-Prevent: Clinical evaluation of metformin for oral cancer precision prevention (2018) (1)
Sa1632 - Metformin is Associated with Reduced Risk for Colorectal Cancer Among Diabetics (2018) (1)
Abstract 351: mTOR-ERK co-targeting strategies for head and neck cancer therapy (2017) (1)
Clinical trial in progress: Phase II trial of defactinib (VS-6063) combined with VS-6766 (CH5126766) in patients with metastatic uveal melanoma. (2021) (1)
Decreased angiotensin II binding affinity and binding capacity in the anterior pituitary gland of adult spontaneously hypertensive rats. (1988) (1)
Genes Important for Disease Progression of MDS-Leukemia Revealed by 40K cDNA Microarray. (2005) (1)
A Randomized Multi-Institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck. (2022) (1)
Arrestins as rheostats of GPCR signalling (2018) (0)
Faculty Opinions recommendation of Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. (2005) (0)
Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry (2022) (0)
Hypoxia-inducible Factor 1 Mitogen-activated Protein Kinase and p 38 Pathways Acting on Growth Factor Expression and Secretion through Protein-coupled Receptor UpRegulates Vascular Endothelial The Kaposi ' s Sarcoma-associated Herpes Virus G Updated (2000) (0)
[VE-cadherin takes a walk on the wild side]. (2007) (0)
[The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins]. (1998) (0)
Crystal structure of 3rd WW domain of human Nedd4-1 (2014) (0)
Novel G protein‐ and GPCR‐Regulated Oncogenic Signaling Circuitries (2013) (0)
O38. Proteomic analysis of laser-captured paraffin-embedded tissues: A molecular portrait of head and neck cancer progression (2009) (0)
Faculty Opinions recommendation of Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (2006) (0)
Faculty Opinions recommendation of Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. (2005) (0)
ID: 366 MT1-MMP Controls Tumor-Induced Angiogenesis through Release of Semaphorin 4D (2006) (0)
Faculty Opinions recommendation of Autocrine VEGF signaling is required for vascular homeostasis. (2007) (0)
S13.1 Genomic approaches in oral cancer: Whathave we learned? (2005) (0)
Protein kinase C isozymes differentially affect intracellular cyclic AMP accumulation (1990) (0)
Abstract 223: Using physical, genetic and integrated cancer cell maps to investigate head and neck cancer and breast cancer (2020) (0)
Human Cancer Biology Activationof themTORPathway inPrimaryMedullary Thyroid Carcinoma and Lymph Node Metastases (2012) (0)
Faculty Opinions recommendation of Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells. (2011) (0)
Abstract PR03: Use of CRISPR knockout screen to identify genes that regulate tumor cell sensitivity to NK cell-based immunotherapy (2020) (0)
Genetic variants affecting equivalent protein family positions reflect human diversity (2017) (0)
Abstract 2339: Halting head & neck squamous cell carcinoma progression by broadly targeting glutamine metabolic pathways (2021) (0)
Bcl 10 / Malt 1 ) Complex B through the CBM κ NF ActivatingVEGFR 2 in Endothelial Cells by Expression and the Autocrine Activation of Endothelial Growth Factor ( VEGF ) CXCL 8 / IL 8 Stimulates Vascular Accelerated (2009) (0)
Faculty Opinions recommendation of The selectivity of protein kinase inhibitors: a further update. (2008) (0)
Abstract LB-159: An orthotopic model of head and neck squamous carcinoma reveals that mTOR inhibition with rapamycin halts lymph node metastasis (2010) (0)
Mo1957 Histopathological and Immune Studies of Angiogenesis and Gastric Cancer Induced by H. pylori Infection and a Dietary Carcinogen in Macaques (2013) (0)
Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4 (2019) (0)
Abstract 1936: Comprehensive long non-coding RNA expression profiling from the TCGA HNSCC RNA-sequencing data (2016) (0)
ERG REGULATES C-MYC AND ABROGATES DIFFERENTIATION IN PROSTATE CANCER (2009) (0)
The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress (2020) (0)
PTEN Downregulation Leads to Augmented Angiogenesis and Increased COX-2 Expression in HNSCC (2014) (0)
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC) (2022) (0)
Abstract 2548: Pentose phosphate pathway inhibition potentiates metformin cytotoxic effects on HNSCC cells (2020) (0)
Correction to: mTOR co-targeting strategies for head and neck cancer therapy (2018) (0)
Faculty Opinions recommendation of GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. (2014) (0)
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell (2018) (0)
Progressive Tumor Formation in Mice with Conditional Deletion of TGF- B Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway Molecular Biology, Pathobiology, and (2009) (0)
Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling (2020) (0)
GNAS‐PKA Oncosignaling Network in Colorectal Cancer (2017) (0)
Animal Model Allows Targeted Delivery of Polyoma MiddleTOncogene toVascular Endothelial Progenitors In vivo and Results in Hemangioma Development (2008) (0)
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAFV600E colorectal tumors (2022) (0)
Illuminating the onco-GPCRome: targeting the prostaglandin receptor-Gαs signaling axis as a novel immune checkpoint in cancer (2020) (0)
G proteins and GPCRs in cancer (2019) (0)
The authors' reply (2007) (0)
Faculty Opinions recommendation of Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. (2005) (0)
Sema3F Suppresses Tumor Initiation Through Alteration of the Immunological Tumor Microenvironment (2020) (0)
Beyond synthetic lethality: charting the landscape of clinically relevant genetic interactions in cancer (2019) (0)
Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma (2020) (0)
Abstract 4800: A next-gen animal model to Study PIK3CA-mTOR driven HPV-related oral malignancies (2017) (0)
A comprehensive list of studies using 4 NQO as an oral carcinogen in mice , either by local ( oral cavity brushing ) or systemic ( drinking water ) delivery (2009) (0)
Abstract A20: Gαq controls the Hippo pathway through MOB1 tyrosine phosphorylation by FAK (2020) (0)
Book Reviews (2000) (0)
Faculty Opinions recommendation of Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex. (2006) (0)
Abstract 1610: Local delivery of anti CTLA4 mediates cDC1 dependent eradication of HNSCC with limited IRAEs in a preclinical model of oral squamous cell carcinoma (2021) (0)
Abstract P1-05-23: Blockade of mTORC1 decreases CXCR4-mediated migration and metastasis (2012) (0)
PD31. Emerging animal models for the functional genomics analysis of the oral cancer oncogenome (2011) (0)
Abstract 2059: Novel roles for GNA13 and RHOA as tumor suppressor genes (2015) (0)
Abstract 3027: Elucidating the role of glutamine metabolism in head & neck squamous cell carcinoma (2022) (0)
Abstract LB-386: Novel multimodal precision immunotherapy by co-targeting the HER3 oncogenic signaling circuitry and PD-1 for head and neck squamous cell carcinoma (2020) (0)
Abstract 1260: CP-31398 prevents the progression of oral squamous cell carcinomas from carcinogen-induced premalignant lesions (2014) (0)
Abstract IA08: Regulation of YAP by tyrosine phosphorylation of core Hippo pathway components: Lessons learned from the GNAQ oncogene and FAK (2020) (0)
Abstract 2619: Whole genome and transcriptome sequencing identifies an activating mutation ofLPAR1in a patient with metastatic neuroblastoma. (2013) (0)
Faculty Opinions recommendation of Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. (2007) (0)
Abstract 4202: Deciphering the effects of GNA13 mutations in B-cell lymphomas (2014) (0)
Pro-oxidants and Injury Effects : Contributors to Tobacco Carcinogenesis in the Lung ? (2005) (0)
The kaposi’s sarcoma associated herpesvirus: a model for viral oncogenesis (2002) (0)
Chapter 34 – Squamous Carcinomas of the Head and Neck: Novel Genomic Approaches (2003) (0)
NEWAPPROACHES TO THEUNDERSTANDING OFTHEMOLECULARBASISOFORALCANCER (2001) (0)
of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in and (2021) (0)
Abstract LB-243: Targeting the PI3K-mTOR signaling with metformin for the prevention of HPV-associated malignancies in HIV- and HIV+ individuals (2014) (0)
Analysis of Anti-Tumor Immune Responses with Radiation Combined with Anti-PD-L1 Immunotherapy in an HPV Specific Head & Neck Cancer Model. (2018) (0)
Abstract 5884:4EBP1is a tumor suppressor gene unleashed by mTOR inhibition in head and neck squamous cell carcinoma (2018) (0)
Abstract LB-48: Somatic mutation of the NMDAR subunit GRIN2A in malignant melanoma results in loss of tumor suppressor activity. (2013) (0)
1 Therapeutics, Targets, and Chemical Biology (2012) (0)
Using global expression changes to determine the function of menin in endocrine tumorigenesis (2007) (0)
Abstract 3249: Recurrent 3p21 deletion in head and neck squamous cell carcinoma identifies SEMA3F as an anti-lymphangiogenic metastasis suppressor gene (2015) (0)
Faculty Opinions recommendation of Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. (2007) (0)
Radiation Combined With CD40 Agonist And PD-1 Blockade Enhances B-cell Tumor Infiltration And Local Tumor Control (2020) (0)
Abstract 1573: MAGED4B drives oral carcinogenesis and is a promising peptide vaccine target for the treatment of oral squamous cell carcinoma (2012) (0)
Dissecting theAkt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer TissueArray Initiative (2007) (0)
CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma. (2023) (0)
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response (2022) (0)
Abstract 4952: Germline variation modulates susceptibility to aggressive disease development in a mouse model of prostate tumorigenesis (2014) (0)
K-15 Signal transduction and oral cancer: Novel therapeutic opportunities? (2005) (0)
A common analgesic enhances the anti-tumour activity of 5-aza-2'-deoxycytidine through induction of oxidative stress (2020) (0)
口腔癌中ADT-mTOR信号传导网络研究现状 (2009) (0)
Promote Squamous Cell Carcinogenesis Compartment that Includes the Stem Cells Is Sufficient to in an Epithelial ras Conditional Expression of K-Updated (2004) (0)
Abstract IA020: Targeting mTOR signaling in oral premalignant lesions: From bench to clinic and back (2022) (0)
Phosphoinositide-3-Kinase Mediated Activation of JNK by the ßPDGFR (1997) (0)
Abstract 3825: Germline modifiers of the tumor immune microenvironment reveal drivers of immunotherapy response (2022) (0)
Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma (2021) (0)
Gαs (GNAS) suppression of the p53 genomic‐stability checkpoint unleashes RAS‐driven oncogenesis (2020) (0)
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor (2018) (0)
Abstract 6406: FAK and MEK co-targeting: A new multimodal precision therapy forGNAQ-driven uveal melanoma (2020) (0)
Crystal Structure of the C‐terminal Guanine Exchange Factor Module of Trio Reveals its Oncogenic Potential (2019) (0)
Disruption of the p16INK4A-CDK4-pRB Tumor Suppressor Pathway and Telomerase-Mediated Immortalization Is Sufficient to Initiate the Malignant Conversion of Primary Oral Keratinocytes (2007) (0)
Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine (2022) (0)
O47. The epithelial-mesenchymal transition inducer, Snail, inhibits terminal differentiation and promotes inflammation and invasion in squamous cell carcinomas (2009) (0)
Nanostructured Immunosensor for Attomolar Detection of Cancer Biomarker IL-8 Using Massively Labeled Superparamagnetic Particles (2012) (0)
Variable Cellular Conduct of Photonic Carbon Nano-Dots (2013) (0)
subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells (2005) (0)
Abstract 828: Common genetic variants influence the composition of the tumor immune microenvironment and host anti-tumor responses (2021) (0)
Squamous Carcinomas of the Head and Neck (2003) (0)
Abstract B51: Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4 (2020) (0)
Abstract 4050: A central role for mTORC1 in CXCR4-mediated directional migration and metastasis (2014) (0)
Abstract 3320: Discovery and development of DNA methylation biomarkers in human papillomavirus related oropharyngeal squamous cell carcinoma (2018) (0)
Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies (2015) (0)
CD40 Agonist Combined with Radiation and PD-1 Blockade Enhances Development Of Systemic Tumor-Specific B-Cells And B-Cell Memory (2020) (0)
Human Cancer Biology Rab 25 Regulates Invasion and Metastasis in Head and Neck Cancer (2013) (0)
LPAR1 (R163W) mutation promotes cell mobility through activation of Rho pathway. (2013) (0)
Beyond synthetic lethality: multiple gene interaction types play a key functional role in cancer (2018) (0)
ACCELERATED COMMUNICATION : G a s activates Cdc 42 via PDZ-RhoGEF (2020) (0)
The landscape of cancer rewired GPCR signaling axes (2023) (0)
Effects of Desipramine on the Cardiovascular Responses to Clonidine and Guanabenz (1986) (0)
Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2019) (0)
Science Signaling Podcast: 20 September 2011 (2011) (0)
Catalytic site mutations confer multiple states of G protein activation (2023) (0)
ActivationofthemTORPathwayinPrimaryMedullaryThyroid Carcinoma and Lymph Node Metastases (2012) (0)
Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity (2023) (0)
Faculty Opinions recommendation of Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. (2008) (0)
Probes for narcotic receptor mediated phenomena 22. (1) synthesis and characterization of optically pure [3H](+)-4-[(αR)-α-((2S, 5R)-4-propyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N, N-diethylbenzamide, [3H]SNC 121, a novel high affinity and select (1996) (0)
Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck ” (2008) (0)
Abstract B023: A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors (2019) (0)
A phase I study of metformin in combination with cisplatin and radiation in locally advanced head and neck squamous cell carcinoma. (2016) (0)
Abstract LB-224: mTOR inhibition can overcome cetuximab resistance in head and neck cancer. (2013) (0)
GnasR201C Induces Murine Pancreatic Cystic Neoplasms through Suppression of YAP1 Signaling and Transcriptional Reprogramming (2018) (0)
711 The molecular anatomy of human oral and cutaneous wound healing (2016) (0)
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. (2018) (0)
Faculty Opinions recommendation of Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. (2002) (0)
Splicing, Mutation, and Methylation Alterations Drive Gene Expression in HPV-OPC more than Copy Number Variation: A Network Propagation Analysis (2020) (0)
Profiling changes in keratinocyte gene expression during wound reepithelialization by laser capture microdissection combined with cDNA array analysis (2001) (0)
Mutated HRAS activates YAP1-AXL signaling to drive metastasis of head and neck cancer. (2023) (0)
Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer (2022) (0)
CHAPTER 218 – G-Protein-Coupled Receptors, Cell Transformation, and Signal Fidelity (2003) (0)
Crystal Structure of the Complex of 3rd WW domain of Human Nedd4 and 1st PPXY Motif of ARRDC3 (2014) (0)

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