J. Silvio Gutkind
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Cell Biology
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Biology
J. Silvio Gutkind's Degrees
- PhD Molecular Biology University of California, San Diego
- Masters Biochemistry University of California, San Diego
- Bachelors Biochemistry University of California, San Diego
Why Is J. Silvio Gutkind Influential?
(Suggest an Edit or Addition)J. Silvio Gutkind's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway (1995) (1695)
- Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate (1996) (1485)
- Integrin function: molecular hierarchies of cytoskeletal and signaling molecules (1995) (1276)
- G-protein-coupled receptors and cancer (2007) (1242)
- G-protein-coupled receptors and signaling networks: emerging paradigms. (2001) (1030)
- Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis (2005) (920)
- G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator (1998) (873)
- VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin (2006) (846)
- Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors (1996) (812)
- The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades* (1998) (799)
- Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product (1997) (796)
- Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. (2009) (778)
- Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits (1994) (763)
- Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ (1997) (720)
- Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging (2007) (719)
- Cbl-b regulates the CD28 dependence of T-cell activation (2000) (620)
- Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. (2006) (614)
- G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension (2008) (563)
- Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. (1996) (514)
- Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. (2009) (469)
- Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. (2010) (456)
- The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer (2013) (443)
- Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. (2014) (439)
- MAP kinases and the control of nuclear events (2007) (432)
- The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α (2000) (404)
- A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho* (1999) (402)
- Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. (2008) (380)
- Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. (2003) (379)
- Dysregulated molecular networks in head and neck carcinogenesis. (2009) (375)
- Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. (2002) (369)
- Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway (1996) (364)
- Activation of Akt/Protein Kinase B by G Protein-coupled Receptors (1998) (364)
- Signaling from E-cadherins to the MAPK Pathway by the Recruitment and Activation of Epidermal Growth Factor Receptors upon Cell-Cell Contact Formation* (2000) (357)
- mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. (2009) (355)
- CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex* (2009) (354)
- The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth* (2001) (336)
- Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. (2010) (316)
- Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays (2000) (305)
- Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis (2010) (301)
- Proteomic profiling of the cancer microenvironment by antibody arrays (2001) (288)
- A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. (2000) (279)
- Illuminating G-Protein-Coupling Selectivity of GPCRs (2019) (278)
- Cell growth control by G protein-coupled receptors: from signal transduction to signal integration (1998) (278)
- Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. (1991) (276)
- Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors (2000) (270)
- Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (2003) (266)
- Regulation of the Transcriptional Activity of c-Fos by ERK (2005) (264)
- TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation (2008) (262)
- Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. (2005) (253)
- RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? (2001) (251)
- Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho (2000) (247)
- mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. (2012) (242)
- Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B (2004) (240)
- The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. (2001) (235)
- Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions (1999) (234)
- Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. (2005) (232)
- Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase (1995) (232)
- A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH2-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5 (1999) (231)
- Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway (*) (1996) (231)
- Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative (2007) (228)
- The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. (1997) (226)
- Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. (1994) (220)
- Novel insights into G protein and G protein-coupled receptor signaling in cancer. (2014) (218)
- Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors Leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF* (2002) (217)
- Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. (2011) (213)
- Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. (2006) (212)
- A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt* (2000) (211)
- Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK) (1995) (208)
- Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. (2010) (202)
- The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. (2004) (201)
- Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation (2000) (199)
- Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. (1990) (198)
- Binding-Induced Folding of a Natively Unstructured Transcription Factor (2008) (198)
- The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. (2006) (195)
- Human tumor-associated viruses and new insights into the molecular mechanisms of cancer (2008) (191)
- Functional roles of Akt signaling in mouse skin tumorigenesis (2002) (190)
- Phosphorylation of c-Fos by Members of the p38 MAPK Family (2005) (189)
- The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. (2000) (188)
- Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma (2004) (187)
- Viral hijacking of G-protein-coupled-receptor signalling networks (2004) (184)
- Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. (2006) (181)
- MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D* (2007) (179)
- The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG (2002) (176)
- Rac1 Function Is Required for Src-induced Transformation (2003) (173)
- MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. (2001) (173)
- IL‐4 activates a distinct signal transduction cascade from IL‐3 in factor‐dependent myeloid cells. (1992) (172)
- Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. (2012) (171)
- A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. (1993) (171)
- Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. (1993) (171)
- mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. (2002) (170)
- Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression (2008) (170)
- mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas (2012) (168)
- Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. (1996) (166)
- Erratum: G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator (1998) (165)
- Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models (2010) (165)
- Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB (2002) (162)
- The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies (2014) (161)
- Calibration of 125I-polymer standards with 125I-brain paste standards for use in quantitative receptor autoradiography (1989) (159)
- Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras (2010) (158)
- Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. (2004) (158)
- Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles. (2011) (156)
- The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells (1996) (156)
- Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway (2005) (155)
- Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3 (2011) (153)
- The Gα13-Rho Signaling Axis Is Required for SDF-1-induced Migration through CXCR4* (2006) (152)
- Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells (1992) (152)
- Phosphorylation of the Carboxyl-Terminal Transactivation Domain of c-Fos by Extracellular Signal-Regulated Kinase Mediates the Transcriptional Activation of AP-1 and Cellular Transformation Induced by Platelet-Derived Growth Factor (2003) (152)
- Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. (2010) (151)
- Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. (2011) (151)
- Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway (2001) (150)
- Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK (2017) (149)
- Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation (2012) (149)
- Potent Activation of RhoA by Gαq and Gq-coupled Receptors* (2002) (147)
- Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer (2011) (146)
- P-Rex1 Links Mammalian Target of Rapamycin Signaling to Rac Activation and Cell Migration* (2007) (146)
- Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. (2000) (145)
- A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells (2011) (140)
- Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret (1998) (139)
- Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. (1988) (137)
- Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation (2012) (137)
- Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer. (2009) (136)
- RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock (2015) (136)
- Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis (2004) (135)
- Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model (2009) (134)
- A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. (2019) (133)
- Regulation of c-myc expression by PDGF through Rho GTPases (2001) (132)
- Regulation of G Protein-linked Guanine Nucleotide Exchange Factors for Rho, PDZ-RhoGEF, and LARG by Tyrosine Phosphorylation (2002) (132)
- Loss of PTEN expression leading to high Akt activation in human multiple myelomas. (2000) (131)
- Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway* (1997) (131)
- Modulation of canonical Wnt signaling by the extracellular matrix component biglycan (2011) (130)
- Plexin-B1 Utilizes RhoA and Rho Kinase to Promote the Integrin-dependent Activation of Akt and ERK and Endothelial Cell Motility* (2007) (127)
- A Human Suppressor of c-Jun N-terminal Kinase 1 Activation by Tumor Necrosis Factor α* (1997) (125)
- Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions (2012) (121)
- Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis (2015) (119)
- Regulation of p73 by c-Abl through the p38 MAP kinase pathway (2002) (115)
- A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. (2013) (114)
- Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential (2004) (114)
- Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6 (2010) (112)
- PTEN deficiency contributes to the development and progression of head and neck cancer. (2013) (111)
- Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. (2016) (110)
- Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. (1991) (108)
- Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. (2017) (108)
- Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. (2013) (108)
- p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. (2012) (107)
- Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. (2008) (106)
- The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. (2004) (105)
- Down-regulation of CXCL5 inhibits squamous carcinogenesis. (2006) (105)
- Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model (2012) (105)
- PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells (2002) (105)
- A role for p38 MAPK in head and neck cancer cell growth and tumor‐induced angiogenesis and lymphangiogenesis (2014) (105)
- Assembly and patterning of the vascular network of the vertebrate hindbrain (2011) (103)
- Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets (1990) (103)
- Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy (2019) (102)
- Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms. (2009) (100)
- Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation* (2003) (100)
- mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations (2014) (100)
- Assembly and activation of the Hippo signalome by FAT1 tumor suppressor (2018) (99)
- Selective Activation of Effector Pathways by Brain-specific G Protein β5* (1996) (99)
- Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. (2008) (99)
- A Common Requirement for the Catalytic Activity and Both SH2 Domains of SHP-2 in Mitogen-activated Protein (MAP) Kinase Activation by the ErbB Family of Receptors (1998) (98)
- c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase (2010) (98)
- VE-cadherin and claudin-5: it takes two to tango (2008) (97)
- Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction (1991) (96)
- Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. (2007) (96)
- Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6 (2010) (96)
- The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. (2006) (96)
- The p53 tumor suppressor targets a novel regulator of G protein signaling. (1997) (95)
- Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. (1994) (93)
- Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation (1997) (93)
- Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility (2008) (93)
- Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. (1989) (93)
- Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12 (2005) (92)
- Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway. (2000) (92)
- Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways (2002) (91)
- Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays (2004) (90)
- Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from Gα12/13 and Gα11/q* (2008) (90)
- Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes (1994) (90)
- Phosphoinositide 3-Kinase γ Is a Mediator of Gβγ-dependent Jun Kinase Activation* (1998) (90)
- Rac1 Is Required for Epithelial Stem Cell Function during Dermal and Oral Mucosal Wound Healing but Not for Tissue Homeostasis in Mice (2010) (89)
- Faculty Opinions recommendation of Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. (2008) (89)
- A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. (2010) (88)
- Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. (2009) (88)
- Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades (1999) (88)
- LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma (2016) (88)
- Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. (2005) (87)
- P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor (2004) (87)
- Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma (2003) (86)
- Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin. (2008) (86)
- Signals and Receptors. (2016) (86)
- Robo4 Signaling in Endothelial Cells Implies Attraction Guidance Mechanisms* (2006) (86)
- Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis (2006) (86)
- Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. (2001) (86)
- Angiotensin II binding sites in the conduction system of rat hearts. (1987) (85)
- PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma (2015) (84)
- The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. (2009) (84)
- Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. (2009) (84)
- Chemical Carcinogenesis Models for Evaluating Molecular-Targeted Prevention and Treatment of Oral Cancer (2009) (83)
- E-cadherin and Hakai: signalling, remodeling or destruction? (2002) (83)
- Complementary Roles of Intracellular and Pericellular Collagen Degradation Pathways In Vivo (2007) (82)
- Biology of advanced uveal melanoma and next steps for clinical therapeutics (2014) (79)
- Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries. (2000) (79)
- Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The β-Catenin Connection (2006) (79)
- Global gene expression profiles of human head and neck squamous carcinoma cell lines (2004) (78)
- Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. (1998) (78)
- Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. (2012) (78)
- Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor* (1999) (78)
- Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4 (2019) (77)
- NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell (2016) (76)
- Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature* (2008) (75)
- Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009) (75)
- Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. (2012) (74)
- A Role for a CXCR2/Phosphatidylinositol 3-Kinase γ Signaling Axis in Acute and Chronic Vascular Permeability (2009) (74)
- Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (2001) (74)
- CKA, a Novel Multidomain Protein, Regulates the JUN N-Terminal Kinase Signal Transduction Pathway in Drosophila (2002) (74)
- Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? (2004) (73)
- Direct Interaction of p21-Activated Kinase 4 with PDZ-RhoGEF, a G Protein-linked Rho Guanine Exchange Factor* (2004) (72)
- Role for EPS8 in squamous carcinogenesis. (2009) (72)
- Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. (2012) (71)
- Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats. (1988) (71)
- Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2*♦ (2009) (71)
- Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics (2019) (70)
- Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. (2011) (70)
- PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets (2010) (70)
- p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons (2004) (70)
- An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia (2008) (70)
- Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions (2008) (70)
- Engineered Mesenchymal Stem Cells with Enhanced Tropism and Paracrine Secretion of Cytokines and Growth Factors to Treat Traumatic Brain Injury (2015) (69)
- The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma (2010) (69)
- B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade (2020) (69)
- Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk (2006) (68)
- Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. (1997) (67)
- Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. (2016) (67)
- Role of Mitogen-activated Protein Kinases and c-Jun/AP-1 trans-Activating Activity in the Regulation of Protease mRNAs and the Malignant Phenotype in NIH 3T3 Fibroblasts* (1999) (66)
- Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. (2013) (66)
- Inactivating Mutations in GNA13 and RHOA in Burkitt’s Lymphoma and Diffuse Large B cell Lymphoma: A Tumor Suppressor Function for the Gα13/RhoA Axis in B Cells (2015) (66)
- Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer (2013) (65)
- Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis (2013) (65)
- Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway (2014) (65)
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- Interaction between β2- and α2-adrenoceptor responses in the vascular system: effect of clenbuterol (1986) (7)
- Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes. (2019) (7)
- Interactions of protein kinase CK2 subunits. (1999) (7)
- Keeping the epidermal stem cell niche in shape. (2010) (7)
- Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes (2021) (7)
- A new twist for the tumour suppressor hamartin (2000) (7)
- Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer (2012) (7)
- Correction: Rigiracciolo, D.C., et al., IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells 2020, 9, 1010 (2020) (7)
- Phase II trial of everolimus in patients with previously treated recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). (2012) (6)
- Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs. (2022) (6)
- Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: evidence for a PKC and MAP kinase independent pathway. (1998) (6)
- Expression of GNA12 and its role in oral cancer (2011) (6)
- The Next Frontier: Head and Neck Cancer Immunoprevention (2017) (6)
- The Wnt/β-catenin Signaling Circuitry in Head and Neck Cancer (2014) (5)
- Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The B -Catenin Connection (2006) (5)
- Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13. (2004) (5)
- Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components. (2017) (5)
- Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis (2020) (5)
- P-Rex1 links mTOR signaling to Rac activation and cell migration (2007) (5)
- Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC) (2022) (5)
- Further Evidence of Interaction Between Vasodilator β2- and Vasoconstrictor α2-Adrenoceptor–Mediated Responses in Maintaining Vascular Tone in Anesthetized Rats (1989) (5)
- The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins. (1996) (5)
- Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray. (2006) (5)
- Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy (2022) (5)
- PIK3CA mutations in colorectal and breast cancer: impact on oncogenesis and response to nonsteroidal anti-inflammatory drugs (2019) (5)
- Gαs directly drives PDZ-RhoGEF signaling to Cdc42 (2020) (5)
- The PH domain of Ras-GAP is sufficient forin Vitro binding toβγ subunits of heterotrimeric G proteins (1996) (4)
- Development of a yeast-based system to identify new hBRAFV600E functional interactors (2018) (4)
- Effects of clenbuterol treatment on the responses to vasodilators in urethane‐anaesthetized rats (1990) (4)
- Chapter 6 Kaposi's Sarcoma Virally Encoded, G‐Protein–Coupled Receptor (2009) (4)
- The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress (2020) (4)
- Differential Inhibitor of Gβγ Signaling to AKT and ERK Derived from Phosducin-like Protein (2009) (4)
- Autoradiographic quantification of vasoactive intestinal peptide binding sites in sections from human blood mononuclear cell pellets. (1988) (4)
- Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer (2022) (4)
- Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats (1988) (4)
- The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities (1989) (4)
- The Genomic Characterization of Head and Neck Squamous Cell Carcinomas (2016) (4)
- Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes (2019) (4)
- Multi-Institutional Randomized Double-Blind Phase II Trial of Everolimus vs. Placebo as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN) (2020) (4)
- Regulation of mitogen-activated protein kinases by G-protein-coupled receptors. (2002) (4)
- Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential. (2019) (3)
- Cardiovascular effects of alpha-adrenergic drugs: Differences between clonidine and guanabenz (1986) (3)
- Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats. (1989) (3)
- Characterization of β-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography (1988) (3)
- Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives are Potent and Selective σ1 Ligands. (1994) (3)
- Single-walled carbon-nanotube forest immunosensor for amplified detection of cancer biomarkers (2006) (3)
- Targeting the mTOR Signaling Circuitry in Head and Neck Cancer (2017) (3)
- Different pharmacological interaction of clonidine and guanabenz with antidepressive drugs. (1987) (3)
- Sonic Hedgehog in SCLC (2015) (3)
- Gαs Directly Drives PDZ‐RhoGEF Signaling to Cdc42 (2020) (3)
- Ataxia telangiectasia mutated nuclear localization in head and neck cancer cells is PPP2R2B-dependent (2010) (3)
- Interaction between beta 2- and alpha 2-adrenoceptor responses in the vascular system: effect of clenbuterol. (1986) (2)
- Emerging Cancer Biomarkers for HNSCC Detection and Therapeutic Intervention (2017) (2)
- The homozygous CX 3 CR 1M 280 mutation impairs human monocyte survival (2018) (2)
- PRECOGx: exploring GPCR signaling mechanisms with deep protein representations (2022) (2)
- Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs (2021) (2)
- Pressor response induced by clenbuterol treatment in immobilized normotensive rats. (1989) (2)
- Meeting Report—The NIDCR 2nd Salivary Gland Tumor Meeting, November 2008 (2009) (2)
- GNAS‐PKA Oncosignaling Network in Colorectal Cancer (2018) (2)
- A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing GPCR-initiated mitogenic signals (2013) (2)
- Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia (1984) (2)
- Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies (2011) (2)
- Molecular Mechanisms of Cancer (2003) (2)
- Activation of GPCR-Gαi signaling increases keratinocyte proliferation and reduces differentiation, leading to epidermal hyperplasia. (2019) (2)
- 1395 Unique transcriptional signature primes oral mucosa for rapid wound healing in humans (2018) (2)
- CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NF through the CBM Complex (2020) (1)
- Abstract 968: Targeting FAK inhibits YAP-dependent tumor growth in uveal melanoma (2018) (1)
- Challenges and Emerging Opportunities for Targeting mTOR in Cancer. (2022) (1)
- Targeting mTOR in Head and Neck Cancer—Response (2019) (1)
- A phase I dose-finding study of metformin in combination with concurrent cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma. (2018) (1)
- PRK AND ROCK ARE REQUIRED FOR THROMBIN-INDUCED ENDOTHELIAL CELL PERMEABILITY DOWNSTREAM FROM Gα12/13 and Gα11/q (2008) (1)
- Abstract 1425: Synergistic antitumor efficacy of the dual RAF/MEK inhibitor VS-6766 with FAK inhibition for treatment of RAS-dependent solid tumors (2021) (1)
- THE FOLDING AND BINDING PATHWAY OF THE TRANSCRIPTION FACTOR CREB TO CBP (2007) (1)
- Cancer Therapy : Preclinical Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically De fi ned Head and Neck Squamous Cell Carcinoma Mouse Model (2012) (1)
- Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary (2004) (1)
- Endocannabinoids as emerging suppressors of angiogenesis and breast tumor growth and metastatic spreading ” (2008) (1)
- Cryo-electron microscopy structure and analysis of the P-Rex1-G-Beta-Gamma signaling scaffold (2019) (1)
- Abstract LB-7: HPV-associated HNSCC: Widespread mTOR pathway activity and preclinical evaluation of mTOR inhibitors rapamycin and RAD-001 (2011) (1)
- 1 Interaction between FGFR-2 , STAT 5 and progesterone receptors in breast cancer (2011) (1)
- Therapeutics , Targets , and Chemical Biology p 21-Activated Kinase 1 Is Required for Ef fi cient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model (2012) (1)
- Identifying novel molecular vulnerabilities to PTK2/FAK inhibition in G α q‐driven uveal melanoma using a kinome‐wide CRISPR/Cas9 screen (2019) (1)
- Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2018) (1)
- Correction to: mTOR co-targeting strategies for head and neck cancer therapy (2018) (1)
- Antitumor activity of tipifarnib and PI3K pathway inhibitors in HRAS-associated HNSCC. (2020) (1)
- Role in the AP-1 response to UV (2005) (1)
- HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer (2022) (1)
- Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1 (2022) (1)
- Faculty Opinions recommendation of Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. (2005) (1)
- Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models (2014) (1)
- Somatic 9p24.1 alterations in HPV– head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity (2022) (1)
- MKP 1 mediates chemosensitizer effects of E 1 a in response to cisplatin in non-small cell lung carcinoma cells (2017) (1)
- Signaling from G-Protein-Coupled Receptors to the Nucleus (2000) (1)
- O127. EPS8 in squamous carcinogenesis (2009) (1)
- G Protein-Coupled Receptors: RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling (2010) (1)
- Rab 25 in head and neck cancer metastasis 1 Rab 25 regulates invasion and metastasis in head and neck cancer (2012) (1)
- Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling (2011) (1)
- A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors (2023) (1)
- GPCRs in head and neck squamous cell carcinoma (2020) (1)
- G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation (2010) (1)
- Abstract 4985: M4OC-Prevent: Clinical evaluation of metformin for oral cancer precision prevention (2018) (1)
- Sa1632 - Metformin is Associated with Reduced Risk for Colorectal Cancer Among Diabetics (2018) (1)
- Abstract 351: mTOR-ERK co-targeting strategies for head and neck cancer therapy (2017) (1)
- Clinical trial in progress: Phase II trial of defactinib (VS-6063) combined with VS-6766 (CH5126766) in patients with metastatic uveal melanoma. (2021) (1)
- Decreased angiotensin II binding affinity and binding capacity in the anterior pituitary gland of adult spontaneously hypertensive rats. (1988) (1)
- Genes Important for Disease Progression of MDS-Leukemia Revealed by 40K cDNA Microarray. (2005) (1)
- A Randomized Multi-Institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck. (2022) (1)
- Arrestins as rheostats of GPCR signalling (2018) (0)
- Faculty Opinions recommendation of Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. (2005) (0)
- Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry (2022) (0)
- Hypoxia-inducible Factor 1 Mitogen-activated Protein Kinase and p 38 Pathways Acting on Growth Factor Expression and Secretion through Protein-coupled Receptor UpRegulates Vascular Endothelial The Kaposi ' s Sarcoma-associated Herpes Virus G Updated (2000) (0)
- [VE-cadherin takes a walk on the wild side]. (2007) (0)
- [The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins]. (1998) (0)
- Crystal structure of 3rd WW domain of human Nedd4-1 (2014) (0)
- Novel G protein‐ and GPCR‐Regulated Oncogenic Signaling Circuitries (2013) (0)
- O38. Proteomic analysis of laser-captured paraffin-embedded tissues: A molecular portrait of head and neck cancer progression (2009) (0)
- Faculty Opinions recommendation of Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (2006) (0)
- Faculty Opinions recommendation of Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. (2005) (0)
- ID: 366 MT1-MMP Controls Tumor-Induced Angiogenesis through Release of Semaphorin 4D (2006) (0)
- Faculty Opinions recommendation of Autocrine VEGF signaling is required for vascular homeostasis. (2007) (0)
- S13.1 Genomic approaches in oral cancer: Whathave we learned? (2005) (0)
- Protein kinase C isozymes differentially affect intracellular cyclic AMP accumulation (1990) (0)
- Abstract 223: Using physical, genetic and integrated cancer cell maps to investigate head and neck cancer and breast cancer (2020) (0)
- Human Cancer Biology Activationof themTORPathway inPrimaryMedullary Thyroid Carcinoma and Lymph Node Metastases (2012) (0)
- Faculty Opinions recommendation of Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells. (2011) (0)
- Abstract PR03: Use of CRISPR knockout screen to identify genes that regulate tumor cell sensitivity to NK cell-based immunotherapy (2020) (0)
- Genetic variants affecting equivalent protein family positions reflect human diversity (2017) (0)
- Abstract 2339: Halting head & neck squamous cell carcinoma progression by broadly targeting glutamine metabolic pathways (2021) (0)
- Bcl 10 / Malt 1 ) Complex B through the CBM κ NF ActivatingVEGFR 2 in Endothelial Cells by Expression and the Autocrine Activation of Endothelial Growth Factor ( VEGF ) CXCL 8 / IL 8 Stimulates Vascular Accelerated (2009) (0)
- Faculty Opinions recommendation of The selectivity of protein kinase inhibitors: a further update. (2008) (0)
- Abstract LB-159: An orthotopic model of head and neck squamous carcinoma reveals that mTOR inhibition with rapamycin halts lymph node metastasis (2010) (0)
- Mo1957 Histopathological and Immune Studies of Angiogenesis and Gastric Cancer Induced by H. pylori Infection and a Dietary Carcinogen in Macaques (2013) (0)
- Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4 (2019) (0)
- Abstract 1936: Comprehensive long non-coding RNA expression profiling from the TCGA HNSCC RNA-sequencing data (2016) (0)
- ERG REGULATES C-MYC AND ABROGATES DIFFERENTIATION IN PROSTATE CANCER (2009) (0)
- The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress (2020) (0)
- PTEN Downregulation Leads to Augmented Angiogenesis and Increased COX-2 Expression in HNSCC (2014) (0)
- Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC) (2022) (0)
- Abstract 2548: Pentose phosphate pathway inhibition potentiates metformin cytotoxic effects on HNSCC cells (2020) (0)
- Correction to: mTOR co-targeting strategies for head and neck cancer therapy (2018) (0)
- Faculty Opinions recommendation of GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. (2014) (0)
- Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell (2018) (0)
- Progressive Tumor Formation in Mice with Conditional Deletion of TGF- B Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway Molecular Biology, Pathobiology, and (2009) (0)
- Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling (2020) (0)
- GNAS‐PKA Oncosignaling Network in Colorectal Cancer (2017) (0)
- Animal Model Allows Targeted Delivery of Polyoma MiddleTOncogene toVascular Endothelial Progenitors In vivo and Results in Hemangioma Development (2008) (0)
- A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAFV600E colorectal tumors (2022) (0)
- Illuminating the onco-GPCRome: targeting the prostaglandin receptor-Gαs signaling axis as a novel immune checkpoint in cancer (2020) (0)
- G proteins and GPCRs in cancer (2019) (0)
- The authors' reply (2007) (0)
- Faculty Opinions recommendation of Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. (2005) (0)
- Sema3F Suppresses Tumor Initiation Through Alteration of the Immunological Tumor Microenvironment (2020) (0)
- Beyond synthetic lethality: charting the landscape of clinically relevant genetic interactions in cancer (2019) (0)
- Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma (2020) (0)
- Abstract 4800: A next-gen animal model to Study PIK3CA-mTOR driven HPV-related oral malignancies (2017) (0)
- A comprehensive list of studies using 4 NQO as an oral carcinogen in mice , either by local ( oral cavity brushing ) or systemic ( drinking water ) delivery (2009) (0)
- Abstract A20: Gαq controls the Hippo pathway through MOB1 tyrosine phosphorylation by FAK (2020) (0)
- Book Reviews (2000) (0)
- Faculty Opinions recommendation of Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex. (2006) (0)
- Abstract 1610: Local delivery of anti CTLA4 mediates cDC1 dependent eradication of HNSCC with limited IRAEs in a preclinical model of oral squamous cell carcinoma (2021) (0)
- Abstract P1-05-23: Blockade of mTORC1 decreases CXCR4-mediated migration and metastasis (2012) (0)
- PD31. Emerging animal models for the functional genomics analysis of the oral cancer oncogenome (2011) (0)
- Abstract 2059: Novel roles for GNA13 and RHOA as tumor suppressor genes (2015) (0)
- Abstract 3027: Elucidating the role of glutamine metabolism in head & neck squamous cell carcinoma (2022) (0)
- Abstract LB-386: Novel multimodal precision immunotherapy by co-targeting the HER3 oncogenic signaling circuitry and PD-1 for head and neck squamous cell carcinoma (2020) (0)
- Abstract 1260: CP-31398 prevents the progression of oral squamous cell carcinomas from carcinogen-induced premalignant lesions (2014) (0)
- Abstract IA08: Regulation of YAP by tyrosine phosphorylation of core Hippo pathway components: Lessons learned from the GNAQ oncogene and FAK (2020) (0)
- Abstract 2619: Whole genome and transcriptome sequencing identifies an activating mutation ofLPAR1in a patient with metastatic neuroblastoma. (2013) (0)
- Faculty Opinions recommendation of Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. (2007) (0)
- Abstract 4202: Deciphering the effects of GNA13 mutations in B-cell lymphomas (2014) (0)
- Pro-oxidants and Injury Effects : Contributors to Tobacco Carcinogenesis in the Lung ? (2005) (0)
- The kaposi’s sarcoma associated herpesvirus: a model for viral oncogenesis (2002) (0)
- Chapter 34 – Squamous Carcinomas of the Head and Neck: Novel Genomic Approaches (2003) (0)
- NEWAPPROACHES TO THEUNDERSTANDING OFTHEMOLECULARBASISOFORALCANCER (2001) (0)
- of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in and (2021) (0)
- Abstract LB-243: Targeting the PI3K-mTOR signaling with metformin for the prevention of HPV-associated malignancies in HIV- and HIV+ individuals (2014) (0)
- Analysis of Anti-Tumor Immune Responses with Radiation Combined with Anti-PD-L1 Immunotherapy in an HPV Specific Head & Neck Cancer Model. (2018) (0)
- Abstract 5884:4EBP1is a tumor suppressor gene unleashed by mTOR inhibition in head and neck squamous cell carcinoma (2018) (0)
- Abstract LB-48: Somatic mutation of the NMDAR subunit GRIN2A in malignant melanoma results in loss of tumor suppressor activity. (2013) (0)
- 1 Therapeutics, Targets, and Chemical Biology (2012) (0)
- Using global expression changes to determine the function of menin in endocrine tumorigenesis (2007) (0)
- Abstract 3249: Recurrent 3p21 deletion in head and neck squamous cell carcinoma identifies SEMA3F as an anti-lymphangiogenic metastasis suppressor gene (2015) (0)
- Faculty Opinions recommendation of Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. (2007) (0)
- Radiation Combined With CD40 Agonist And PD-1 Blockade Enhances B-cell Tumor Infiltration And Local Tumor Control (2020) (0)
- Abstract 1573: MAGED4B drives oral carcinogenesis and is a promising peptide vaccine target for the treatment of oral squamous cell carcinoma (2012) (0)
- Dissecting theAkt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer TissueArray Initiative (2007) (0)
- CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma. (2023) (0)
- Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response (2022) (0)
- Abstract 4952: Germline variation modulates susceptibility to aggressive disease development in a mouse model of prostate tumorigenesis (2014) (0)
- K-15 Signal transduction and oral cancer: Novel therapeutic opportunities? (2005) (0)
- A common analgesic enhances the anti-tumour activity of 5-aza-2'-deoxycytidine through induction of oxidative stress (2020) (0)
- 口腔癌中ADT-mTOR信号传导网络研究现状 (2009) (0)
- Promote Squamous Cell Carcinogenesis Compartment that Includes the Stem Cells Is Sufficient to in an Epithelial ras Conditional Expression of K-Updated (2004) (0)
- Abstract IA020: Targeting mTOR signaling in oral premalignant lesions: From bench to clinic and back (2022) (0)
- Phosphoinositide-3-Kinase Mediated Activation of JNK by the ßPDGFR (1997) (0)
- Abstract 3825: Germline modifiers of the tumor immune microenvironment reveal drivers of immunotherapy response (2022) (0)
- Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma (2021) (0)
- Gαs (GNAS) suppression of the p53 genomic‐stability checkpoint unleashes RAS‐driven oncogenesis (2020) (0)
- Assembly and activation of the Hippo signalome by FAT1 tumor suppressor (2018) (0)
- Abstract 6406: FAK and MEK co-targeting: A new multimodal precision therapy forGNAQ-driven uveal melanoma (2020) (0)
- Crystal Structure of the C‐terminal Guanine Exchange Factor Module of Trio Reveals its Oncogenic Potential (2019) (0)
- Disruption of the p16INK4A-CDK4-pRB Tumor Suppressor Pathway and Telomerase-Mediated Immortalization Is Sufficient to Initiate the Malignant Conversion of Primary Oral Keratinocytes (2007) (0)
- Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine (2022) (0)
- O47. The epithelial-mesenchymal transition inducer, Snail, inhibits terminal differentiation and promotes inflammation and invasion in squamous cell carcinomas (2009) (0)
- Nanostructured Immunosensor for Attomolar Detection of Cancer Biomarker IL-8 Using Massively Labeled Superparamagnetic Particles (2012) (0)
- Variable Cellular Conduct of Photonic Carbon Nano-Dots (2013) (0)
- subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells (2005) (0)
- Abstract 828: Common genetic variants influence the composition of the tumor immune microenvironment and host anti-tumor responses (2021) (0)
- Squamous Carcinomas of the Head and Neck (2003) (0)
- Abstract B51: Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4 (2020) (0)
- Abstract 4050: A central role for mTORC1 in CXCR4-mediated directional migration and metastasis (2014) (0)
- Abstract 3320: Discovery and development of DNA methylation biomarkers in human papillomavirus related oropharyngeal squamous cell carcinoma (2018) (0)
- Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies (2015) (0)
- CD40 Agonist Combined with Radiation and PD-1 Blockade Enhances Development Of Systemic Tumor-Specific B-Cells And B-Cell Memory (2020) (0)
- Human Cancer Biology Rab 25 Regulates Invasion and Metastasis in Head and Neck Cancer (2013) (0)
- LPAR1 (R163W) mutation promotes cell mobility through activation of Rho pathway. (2013) (0)
- Beyond synthetic lethality: multiple gene interaction types play a key functional role in cancer (2018) (0)
- ACCELERATED COMMUNICATION : G a s activates Cdc 42 via PDZ-RhoGEF (2020) (0)
- The landscape of cancer rewired GPCR signaling axes (2023) (0)
- Effects of Desipramine on the Cardiovascular Responses to Clonidine and Guanabenz (1986) (0)
- Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2019) (0)
- Science Signaling Podcast: 20 September 2011 (2011) (0)
- Catalytic site mutations confer multiple states of G protein activation (2023) (0)
- ActivationofthemTORPathwayinPrimaryMedullaryThyroid Carcinoma and Lymph Node Metastases (2012) (0)
- Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity (2023) (0)
- Faculty Opinions recommendation of Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. (2008) (0)
- Probes for narcotic receptor mediated phenomena 22. (1) synthesis and characterization of optically pure [3H](+)-4-[(αR)-α-((2S, 5R)-4-propyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N, N-diethylbenzamide, [3H]SNC 121, a novel high affinity and select (1996) (0)
- Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck ” (2008) (0)
- Abstract B023: A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors (2019) (0)
- A phase I study of metformin in combination with cisplatin and radiation in locally advanced head and neck squamous cell carcinoma. (2016) (0)
- Abstract LB-224: mTOR inhibition can overcome cetuximab resistance in head and neck cancer. (2013) (0)
- GnasR201C Induces Murine Pancreatic Cystic Neoplasms through Suppression of YAP1 Signaling and Transcriptional Reprogramming (2018) (0)
- 711 The molecular anatomy of human oral and cutaneous wound healing (2016) (0)
- The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. (2018) (0)
- Faculty Opinions recommendation of Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. (2002) (0)
- Splicing, Mutation, and Methylation Alterations Drive Gene Expression in HPV-OPC more than Copy Number Variation: A Network Propagation Analysis (2020) (0)
- Profiling changes in keratinocyte gene expression during wound reepithelialization by laser capture microdissection combined with cDNA array analysis (2001) (0)
- Mutated HRAS activates YAP1-AXL signaling to drive metastasis of head and neck cancer. (2023) (0)
- Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer (2022) (0)
- CHAPTER 218 – G-Protein-Coupled Receptors, Cell Transformation, and Signal Fidelity (2003) (0)
- Crystal Structure of the Complex of 3rd WW domain of Human Nedd4 and 1st PPXY Motif of ARRDC3 (2014) (0)
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What Schools Are Affiliated With J. Silvio Gutkind?
J. Silvio Gutkind is affiliated with the following schools: