J. Thomas Parsons

J. Thomas Parsons's AcademicInfluence.com Rankings

J. Thomas Parsons

Biology

#6849

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#9652

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Cell Biology

#239

World Rank

#247

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Biology

J. Thomas Parsons's Degrees

Bachelors Biology University of California, Riverside

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J. Thomas Parsons's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cell Migration: Integrating Signals from Front to Back (2003) (4885)
Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010) (1736)
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. (1992) (1455)
Focal adhesion kinase: the first ten years (2003) (1365)
FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly (2004) (1358)
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src (1994) (1297)
Src family kinases, key regulators of signal transduction (2004) (875)
Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again (2002) (784)
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. (1992) (742)
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains (1995) (670)
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets (1992) (666)
Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement (2000) (664)
HDAC6 modulates cell motility by altering the acetylation level of cortactin. (2007) (632)
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation (2001) (595)
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk (1995) (574)
Focal adhesion kinase and associated proteins. (1994) (542)
Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex (1993) (525)
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK (1994) (494)
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. (1990) (452)
Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor* (2007) (450)
A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK (1996) (436)
Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin (*) (1995) (417)
Identification and characterization of a novel cytoskeleton-associated pp60src substrate (1991) (415)
Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-Actin and the Arp2/3 Complex (2000) (413)
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions (1993) (410)
Cortactin: coupling membrane dynamics to cortical actin assembly (2001) (409)
Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. (1997) (409)
Cell Migration--Movin' On (1999) (397)
p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase* (1996) (369)
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene (1989) (358)
Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. (1995) (353)
Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation (1997) (345)
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase (1996) (341)
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK (1993) (320)
Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins. (1996) (317)
Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype (2010) (302)
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation (2003) (273)
Signal transduction through integrins: A central role for focal adhesion kinase? (1995) (272)
Interaction of Cortactin and N-WASp with Arp2/3 Complex (2002) (262)
Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons (1998) (256)
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. (1994) (243)
Integrin connections map: to infinity and beyond. (2002) (239)
Adhesion-induced tyrosine phosphorylation of the p130 src substrate. (1995) (221)
Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells (2001) (215)
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases. (1999) (206)
The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. (1991) (204)
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. (1998) (197)
Dynamin2 and Cortactin Regulate Actin Assembly and Filament Organization (2002) (195)
SH2 domain specificity and activity modified by a single residue (1994) (190)
Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment (2011) (190)
Biochemical studies on adenovirus multiplication. 18. Resolution of early virus-specific RNA species in Ad 2 infected and transformed cells. (1969) (186)
Cortactin Interacts with WIP in Regulating Arp2/3 Activation and Membrane Protrusion (2003) (182)
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. (2003) (179)
Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase (1997) (176)
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins (1989) (176)
Selective Expression of an Endogenous Inhibitor of FAK Regulates Proliferation and Migration of Vascular Smooth Muscle Cells (2001) (171)
Focal adhesion kinase: an integrin-linked protein tyrosine kinase. (1993) (170)
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells (2005) (164)
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase (2007) (163)
Genetics of src: structure and functional organization of a protein tyrosine kinase. (1989) (160)
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. (2002) (159)
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. (2008) (153)
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein (1994) (148)
A Role for Focal Adhesion Kinase in Phenylephrine-induced Hypertrophy of Rat Ventricular Cardiomyocytes* (2000) (146)
Mitogen-Activated Protein Kinase Feedback Phosphorylation Regulates MEK1 Complex Formation and Activation during Cellular Adhesion (2004) (142)
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. (1996) (141)
Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin. (1993) (140)
Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells (1991) (136)
The nucleotide sequence complexity of avian tumor virus RNA. (1974) (135)
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. (1987) (133)
FAK phosphorylation sites mapped by mass spectrometry (2005) (125)
The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor. (1993) (121)
Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin (1984) (117)
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. (1998) (115)
pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src (1989) (115)
Stable Association of PYK2 and p130Cas in Osteoclasts and Their Co-localization in the Sealing Zone* (1999) (113)
Regulated Expression of Focal Adhesion Kinase-Related Nonkinase, the Autonomously Expressed C-Terminal Domain of Focal Adhesion Kinase (1999) (113)
Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention (2008) (112)
Transcription of Adenovirus Genes in Productively Infected and in Transformed Cells (1970) (112)
Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate (1993) (111)
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts (2006) (106)
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts (2008) (106)
Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. (1999) (101)
The identification of p130cas-binding proteins and their role in cellular transformation. (1996) (100)
Local degradation of fibronectin at sites of expression of the transforming gene product pp60src (1985) (95)
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. (2003) (94)
Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas). (2001) (94)
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells (2004) (91)
Focal adhesion kinase: structure and signalling (1994) (87)
RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility (2007) (85)
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein (1991) (81)
Expression of focal adhesion kinase in normal and pathologic human prostate tissues (2002) (81)
Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib. (2013) (76)
Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95. (1988) (76)
Characterization of Graf, the GTPase-activating Protein for Rho Associated with Focal Adhesion Kinase (1998) (75)
Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway* (1996) (75)
Clinical, Molecular and Genetic Validation of a Murine Orthotopic Xenograft Model of Pancreatic Adenocarcinoma Using Fresh Human Specimens (2013) (72)
Immunoaffinity purification of tyrosine-phosphorylated cellular proteins. (1989) (72)
Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells. (2009) (71)
Mislocalization or Reduced Expression of Arf GTPase-activating Protein ASAP1 Inhibits Cell Spreading and Migration by Influencing Arf1 GTPase Cycling* (2005) (71)
Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity (1984) (68)
Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation (1982) (66)
Emerging views of integrin signaling: Implications for prostate cancer (2004) (65)
Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate. (1992) (63)
Quantitative Determination and Location of Newly Synthesized Virus-Specific Ribonucleic Acid in Chicken Cells Infected with Rous Sarcoma Virus (1973) (61)
Matrix Rigidity Regulates Cancer Cell Growth by Modulating Cellular Metabolism and Protein Synthesis (2012) (60)
CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer (2017) (57)
In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase. (1974) (57)
Extracellular Signal-Regulated Kinase 2 (ERK2) Phosphorylation Sites and Docking Domain on the Nuclear Pore Complex Protein Tpr Cooperatively Regulate ERK2-Tpr Interaction (2008) (54)
Rapidly labeled messenger ribonucleic acid-protein complex of rat liver nuclei. (1968) (54)
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability (1989) (53)
Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins (1986) (49)
Biochemical studies on adenovirus multiplication, XIX. Resolution of late viral RNA species in the nucleus and cytoplasm. (1971) (49)
Molecular cloning of avian sarcoma virus closed circular DNA: structural and biological characterization of three recombinant clones (1980) (48)
In vitro synthesis of a unique RNA species by a T particle of vesicular stomatitis virus (1977) (48)
SRChing for the substrates of Src (2014) (48)
Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes* (2002) (48)
Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model (2009) (47)
c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes. (2001) (47)
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. (2012) (47)
RNase H hydrolysis of the 5′ terminus of the avian sarcoma virus genome during reverse transcription (1978) (45)
Avian Retrovirus pp32 DNA-Binding Protein I. Recognition of Specific Sequences on Retrovirus DNA Terminal Repeats (1982) (44)
Cortactin phosphorylation sites mapped by mass spectrometry (2006) (43)
The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors. (1994) (43)
CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response (2018) (41)
Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation (1985) (40)
A novel role for signal transducer and activator of transcription 5b (STAT5b) in β1-integrin-mediated human breast cancer cell migration (2009) (36)
Oncogene-mediated multistep transformation of C3H10T1/2 cells. (1987) (36)
Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus. (1970) (34)
c-Raf-mediated Inhibition of Epidermal Growth Factor-stimulated Cell Migration* (1999) (34)
Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A. (1997) (34)
Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase. (2001) (33)
FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury (2008) (32)
Identification and characterization of novel substrates for protein tyrosine kinases. (1993) (32)
A Thirteen-Gene Expression Signature Predicts Survival of Patients with Pancreatic Cancer and Identifies New Genes of Interest (2014) (31)
Identification of phosphorylation sites in βPIX and PAK1 (2007) (31)
Co-Treatment with Panitumumab and Trastuzumab Augments Response to the MEK Inhibitor Trametinib in a Patient-Derived Xenograft Model of Pancreatic Cancer1 (2014) (30)
Structure of the BH Domain from Graf and Its Implications for Rho GTPase Recognition* (2000) (30)
A new approach to the isolation of RNA-DNA hybrids and its application to the quantitative determination of labeled tumor virus RNA. (1974) (30)
Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein. (1987) (30)
Integrin-mediated signaling in normal and malignant cells: a role of protein tyrosine kinases. (1996) (30)
The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. (2013) (30)
Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas). (2000) (29)
Protein-synthetic capacities of liver nuclear subfractions. (1966) (28)
Identification of transcriptional elements within the long terminal repeat of Rous sarcoma virus (1983) (27)
Protein-tyrosine kinases, oncogenes, and cancer. (1993) (27)
Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein (1986) (27)
Analysis of cellular integration sites in avian sarcoma virus infected duck embryo cells (1979) (25)
Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product (1983) (25)
Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli. (1982) (24)
Studies on the structure and synthesis of Rous sarcoma virus RNA. (1975) (24)
Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch". (2002) (23)
Immune response to the src gene product in mice bearing tumors induced by injection of avian sarcoma virus-transformed mouse cells (1979) (22)
Chicken Macrophage Stimulating Protein Is a Ligand of the Receptor Protein-tyrosine Kinase Sea* (1999) (21)
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. (2012) (21)
Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527. (1993) (20)
FRNK, the autonomously expressed C‐terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: Analysis of expression in transgenic mice (2005) (20)
Closing the GAP in a signal transduction pathway. (1990) (18)
Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells. (2019) (17)
Integration of avian sarcoma virus DNA sequences in transformed mammalian cells. (1977) (17)
Identification of phosphorylation sites in betaPIX and PAK1. (2007) (17)
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis. (1989) (16)
Terminally repeated sequences in the avian sarcoma virus RNA genome. (1977) (16)
Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527) (1991) (16)
Purification of virus-specific RNA from chicken cells infected with avian sarcoma virus: identification of genome-length and subgenome-leghth viral RNAs (1978) (16)
MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages (1987) (15)
Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases. (1996) (14)
Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells. (1988) (14)
Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene (2007) (14)
The Src pathway as a therapeutic strategy (2005) (13)
Direct Proof of the 5′ to 3′ Transcriptional Jump During Reverse Transcription of the Avian Retrovirus Genome by DNA Sequencing (1981) (12)
Arrangement of Integrated Avian Sarcoma Virus DNA Sequences Within the Cellular Genomes of Transformed and Revertant Mammalian Cells (1980) (12)
c-Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor, P190 RhoGAP, and Focal Adhesion Kinase Regulates Diverse Cellular Processes (2001) (11)
Modular domains of focal adhesion-associated proteins. (1998) (11)
Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages (1992) (10)
Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+. (1992) (9)
Breaking barriers through collaboration: the example of the Cell Migration Consortium (2002) (8)
Shifting Paradigms in Tumor Metastasis: Challenges and Opportunities—A Workshop Report (2002) (8)
Monoclonal antibodies specific for the virion polypeptide, p27, of avian retroviruses. (1984) (8)
Deletion mutant of the Bratislava-77 strain of Rous sarcoma virus containing a fusion of the group-specific antigen and envelope genes (1979) (7)
In vitro transcription of reconstituted 35s RNA.tRNAtrp template.primer complexes by the avian oncornavirus DNA polymerase. Effect of temperature on the size of the DNA transcripts. (1978) (7)
Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src (1983) (7)
Structural and functional motifs of the Rous sarcoma virus src protein. (1986) (6)
Characterization of c-myc proteins from avian bursal lymphoma cell lines. (1986) (5)
Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src (1987) (5)
Assay and purification and focal adhesion kinase. (1998) (5)
Identification and Characterization of a Novel Cytoskeleton-Associated pp6Osrc Substrate (5)
Adjuvant Trametinib Delays the Outgrowth of Occult Pancreatic Cancer in a Mouse Model of Patient-Derived Liver Metastasis (2016) (5)
Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src (1991) (4)
Effect of trametinib in combination with panitumumab and trastuzumab on tumor growth in an orthotopic xenograft model of human pancreatic cancer. (2013) (4)
Immunological methods for the detection of phosphotyrosine-containing proteins in neural tissues (1992) (3)
Accelerated fraction radiotherapy with concomitant capecitabine as neoadjuvant therapy of borderline resectable pancreatic cancer. (2012) (3)
CHAPTER 78 – Integrin Signaling: Cell Migration, Proliferation, and Survival (2003) (3)
Interplay between Oncogenes and Tumor Suppressor Genes in Human Disease (2016) (2)
Retroviruses and cancer: models for cancer in animals and humans. (1993) (2)
Focal Adhesion Kinase and its Associated Proteins (2019) (1)
Isolation of antibodies specific for avian viral and cellular myc proteins. (1985) (1)
Reduced Expression of Arf GTPase-activating Protein ASAP 1 Inhibits Cell Spreading and Migration by Influencing Arf 1 GTPase Cycling (2004) (1)
Isolation and Partial Characterization of a Monoclonal Antibody to the Rous Sarcoma Virus Transforming Protein pp 60 src (1)
Mutations within the5'HalfoftheAvianRetrovirus MC29 v-myc GeneAlter orAbolish Transformation ofChicken Embryo Fibroblasts andMacrophages (1992) (0)
Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer (2018) (0)
Abstract 1592: Targeting proliferative signals in patient-derived pancreatic cancers propagated orthotopically in immunocompromised mice (2011) (0)
Abstract 5600: Acquired resistance of pancreatic cancers to combination therapy with lapatinib plus the MEK 1/2 inhibitor GSK1120212: Using a murine orthotopic xenograft model to identify resistance pathways (2012) (0)
The Integrin-Mediated Suppression of Apoptosis Correlates with Suppression of Ceramide Generation † 780 (1998) (0)
Targeting occult metastatic disease: A hematogenously derived xenograft model of human pancreatic tumor growth in the murine liver. (2013) (0)
Abstract 935: Inhibition of pancreatic cancer growth via MEK-targeted therapy is significantly enhanced by concomitant inhibition of EGFR and Her2. (2013) (0)
Abstract LB-158: A human xenograft model for developing personalized targeted therapy for pancreatic cancer (2010) (0)
REQUIREMENT FOR pp125 FOCAL ADHESION KINASE AND c-SRC IN THE INTEGRIN-DEPENDENT ACTIVATION OF p70/p85 RIBOSOMAL S6 KINASE. ▴ 936 (1996) (0)
Abstract C19: The role of resident liver macrophages in suppressing the progression of hepatic micrometastases from pancreatic ductal adenocarcinoma (2016) (0)
CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response (2018) (0)
Inhibition of focal adhesion kinase prevents growth of prostate tumors in mice (2000) (0)
Results Disruption of FAK Expression in the Prostate of Normal and TRAMP Mice To assess the role of FAK in prostate cancer progression in TRAMP mice , normal and TRAMP mice were interbred (2009) (0)
Abstract 4040: The MEK inhibitor trametinib delays tumor outgrowth and prolongs survival in a patient-derived mouse model of occult hepatic metastatic pancreatic cancer (2014) (0)
Oncogene-mediated Multistep Transformation of C 3 H 10 T 1 / 2 Cells 1 (2006) (0)
Focal Adhesion Kinase: Targeting Adhesions Signals in Normal and Cancer Cells (2007) (0)
tyrosine phosphorylation. catalytically inactive FAK: a role for paxillin (FAK) is rescued by coexpression of Src or C-terminal domain of focal adhesion kinase Inhibition of cell spreading by expression of the (2013) (0)
Biochemical Studies on Adenovirus Multi XIX. Resolution of Late Viral RNA Spe4 Nucleus and Cytoplasm (2016) (0)
Expression, purification and crystallization of a novel gtpase activating protein (GAP) associated with focal adhesion kinase (1998) (0)
Cortactin regulates lamellipodia dynamics (2002) (0)
Abstract B21: In a patient-derived xenograft model of occult hepatic metastasis from pancreatic cancer the MEK inhibitor trametinib delays tumor outgrowth and prolongs survival (2014) (0)
Analysis of the Rous Sarcoma Virus Promoter Region by Site-Directed Mutagenesis (1982) (0)
Abstract 808: Combination therapy with a MEK inhibitor plus T-type calcium channel inhibitor is highly effective in patient-derived pancreatic ductal adenocarcinomas (2014) (0)
pp6Ov-src Inactivate Transformation and Modulate Membrane Stability (2003) (0)
Abstract A47: A patient-derived xenograft model of pancreatic cancer in mice to develop novel adjuvant therapies (2016) (0)
Acquired resistance to combination therapy with lapatinib and MEK 1/2 inhibitor GSK1120212 in an in vivo murine model of pancreatic cancer. (2012) (0)
Identification ofTranscriptional Elements Within theLong Terminal Repeat ofRousSarcoma Virus (1983) (0)
Monoclonal Antibody Which Binds Both Amino and Carboxy Peptide Fragments of pp6OV-src (2003) (0)
Abstract LB-241: Cancer-associated fibroblasts modulate growth- and metastasis-promoting pathways in human pancreatic cancer cells and augment orthotopic tumor growth in mice (2010) (0)
Faculty Opinions recommendation of PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. (2008) (0)
Identification and characterization of a 2000,000 dalton tumor antigen on avian sarcoma virus transformed balb/c cells. Abstr. (1982) (0)

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