John W. Daly

Q: What Schools Are Affiliated With John W. Daly

John W. Daly is affiliated with the following schools: Tohoku University, Florida International University, University of Panama, Virginia Military Institute, University of Antananarivo, University of Chicago, Old Dominion University, University of Bonn, Radboud University Nijmegen

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John W. Daly

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John W. Daly's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Nomenclature and classification of purinoceptors. (1994) (1631)
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. (1981) (1546)
Arene oxides: a new aspect of drug metabolism. (1974) (972)
Adenosine receptors and behavioral actions of methylxanthines. (1981) (676)
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. (1981) (657)
Adenosine receptors: targets for future drugs. (1982) (596)
Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds. (2005) (566)
Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines. (1981) (528)
Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. (1980) (489)
Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog (1992) (448)
A RADIOISOTOPIC METHOD FOR MEASURING THE FORMATION OF ADENOSINE 3′,5′‐CYCLIC MONOPHOSPHATE IN INCUBATED SLICES OF BRAIN (1969) (448)
Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds. (1967) (443)
Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate- generating systems, receptors, and enzymes (1985) (400)
1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. (1970) (395)
Forskolin: a unique diterpene activator of cyclic AMP-generating systems. (1981) (390)
A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide. (1971) (388)
Epibatidine, a potent analgetic and nicotinic agonist. (1994) (388)
Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the amphibia. (1987) (359)
A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine. (1960) (354)
Alkylxanthines: inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity. (1979) (301)
Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors. (1971) (298)
Cyclic Nucleotides in the Nervous System (1977) (288)
Adenosine receptor ligands: differences with acute versus chronic treatment. (1996) (266)
Forskolin, cyclic AMP and cellular physiology (1983) (250)
The chemistry of poisons in amphibian skin. (1995) (238)
Forskolin: its biological and chemical properties. (1986) (237)
Caffeine--an atypical drug of dependence. (1998) (234)
4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a potent inhibitor of adenosine cyclic 3',5'-monophosphate phosphodiesterases in homogenates and tissue slices from rat brain. (1976) (223)
Thirty years of discovering arthropod alkaloids in amphibian skin. (1998) (221)
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. (1985) (220)
Role of the arene oxide-oxepin system in the metabolism of aromatic substrates: I. In vitro conversion of benzene oxide to a premercapturic acid and a dihydrodiol (1968) (214)
Toxicity of Panamanian Poison Frogs (Dendrobates): Some Biological and Chemical Aspects (1967) (214)
Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines (1983) (204)
Activation of Cyclic AMP‐Generating Systems in Brain Membranes and Slices by the Diterpene Forskolin: Augmentation of Receptor‐Mediated Responses (1982) (196)
The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. 3. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes. (1968) (195)
Homobatrachotoxin in the genus Pitohui: chemical defense in birds? (1992) (194)
Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. (1988) (191)
Batrachotoxin: Chemistry and Pharmacology (1971) (182)
Nicotinic Agonists, Antagonists, and Modulators From Natural Sources (2005) (179)
8‐(3‐Chlorostyryl)caffeine (CSC) is a selective A2‐adenosine antagonist in vitro and in vivo (1993) (176)
Substrates and inhibitors of dopamine-β-oxidase (1962) (164)
Widespread occurrence in frogs and toads of skin compounds interacting with the ouabain site of Na+, K+-ATPase. (1980) (163)
Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. (1981) (155)
Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs. (2004) (154)
Stimulated formation of adenosine 3',5'-cyclic phosphate in cerebral cortex: synergism between electrical activity and biogenic amines. (1970) (154)
Cis-1,2-dihydroxy-1,2-dihydronaphthalene: a bacterial metabolite from naphthalene. (1971) (150)
Oribatid mites as a major dietary source for alkaloids in poison frogs (2007) (149)
Regulation of phosphatidylinositol turnover in brain synaptoneurosomes: stimulatory effects of agents that enhance influx of sodium ions. (1986) (149)
Classification of skin alkaloids from neotropical poison-dart frogs (Dendrobatidae). (1978) (147)
Adenosine-dependent formation of cyclic AMP in brain slices. (1976) (147)
Conversion of naphthalene to trans-naphthalene dihydrodiol: evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes. (1972) (147)
Effect of gangliosides on adenylate cyclase activity in rat cerebral cortical membranes. (1979) (147)
Catechol-O-methyltransferase. II. A new class of inhibitors of catechol-o-methyltransferase; 3,5-dihydroxy-4-methoxybenzoic acid and related compounds. (1970) (145)
Dart-poison frogs. (1983) (141)
Adenosine-elicited accumulation of cyclic AMP in brain slices: potentiation by agents which inhibit uptake of adenosine. (1974) (141)
ACCUMULATION OF CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE IN CEREBRAL CORTICAL SLICES FROM RAT AND MOUSE: STIMULATORY EFFECT OF α‐ AND β‐ADRENERGIC AGENTS AND ADENOSINE (1973) (140)
An uptake system for dietary alkaloids in poison frogs (Dendrobatidae). (1994) (139)
3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. (1988) (139)
Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. (1994) (136)
Melyrid beetles (Choresine): a putative source for the batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds. (2004) (135)
Maitotoxin: a unique pharmacological tool for research on calcium-dependent mechanisms. (1990) (134)
Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. (1983) (133)
The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex. (1985) (131)
Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to arene oxide pathway. (1975) (129)
Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. (2003) (129)
Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices. (1980) (126)
A dangerously toxic new frog (Phyllobates) used by Emberá Indians of western Colombia, with discussion of blowgun fabrication and dart poisoning. Bulletin of the AMNH ; v. 161, article 2 (1978) (125)
Liver microsomal expoxide hydrase. Solubilization, purification, and characterization. (1975) (124)
Histrionicotoxins: roentgen-ray analysis of the novel allenic and acetylenie spiroalkaloids isolated from a Colombian frog, Dendrobates histrionicus. (1971) (122)
Batrachotoxin alkaloids from passerine birds: a second toxic bird genus (Ifrita kowaldi) from New Guinea. (2000) (121)
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. (2002) (119)
A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase. (1992) (119)
A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor (1986) (119)
Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase. (1973) (118)
Cyclic adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices. I. Formation of cyclic adenosine 3',5'-monophosphate from endogenous adenosine triphosphate and from radioactive adenosine triphosphate formed during a prior incubation with radioactive adenine. (1973) (118)
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. (1986) (118)
Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpene forskolin. (1982) (117)
The structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs. (1969) (116)
Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. IV. Stereochemical considerations of dihydrodiol formation and dehyrogenation (1970) (115)
A role for central A3‐adenosine receptors (1993) (113)
Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor. (1992) (113)
Dietary source for skin alkaloids of poison frogs (Dendrobatidae)? (1994) (109)
Morphology of the granular secretory glands in skin of poison-dart frogs (Dendrobatidae). (1979) (109)
A new class of tyrosine hydroxylase inhibitors and a simple assay of inhibition in vivo. (1967) (108)
Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism. (1991) (107)
The dextro and levorotatory isomers of N-phenylisopropyladenosine: stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices. (1979) (107)
Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years. (2007) (106)
Batrachotoxin-induced depolarization and [3H]batrachotoxinin-a 20 alpha-benzoate binding in a vesicular preparation from guinea pig cerebral cortex. (1983) (106)
Preliminary evaluation of skin toxins and vocalizations in taxonomic and evolutionary studies of poison-dart frogs (Dendrobatidae). Bulletin of the AMNH ; v. 157, article 3 (1976) (106)
Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. (1973) (106)
Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics. (2000) (106)
Cyclic AMP-generating systems: regional differences in activation by adrenergic receptors in rat brain (1981) (103)
Binding of [3H]forskolin to rat brain membranes. (1984) (103)
Physiology and pharmacology of adenosine derivatives (1983) (103)
Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source (2002) (100)
The combined use of α-methyltyrosine and threo-dihydroxyphenylserine—selective reduction of dopamine levels in the central nervous system (1968) (99)
Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. (2003) (99)
Gephyrotoxins, histrionicotoxins and pumiliotoxins from the neotropical frog Dendrobates histrionicus. (1977) (99)
Dynamic aspects of enzymatic O-methylation and -demethylation of catechols in vitro and in vivo. (1960) (99)
Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain (1993) (99)
Monooxygenase activity in Cunninghamella bainieri: evidence for a fungal system similar to liver microsomes. (1973) (98)
Catechol O-methyltransferase. IV. Factors affecting m- and p-methylation of substituted catechols. (1972) (97)
Levels of batrachotoxin and lack of sensitivity to its action in poison-dart frogs (Phyllobates). (1980) (97)
Arene oxides as intermediates in the oxidative metabolism of aromatic compounds. Isomerization of methyl-substituted arene oxides. (1972) (95)
Solubilization, purification, and properties of a hepatic epoxide hydrase. (1971) (94)
Guanosine 5'-(beta, gamma-imido)triphosphate inhibition of forskolin-activated adenylate cyclase is mediated by the putative inhibitory guanine nucleotide regulatory protein. (1982) (94)
Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors. (1986) (94)
Alkaloids from bufonid toads (Melanophryniscus): decahydroquinolines, pumiliotoxins and homopumiliotoxins, indolizidines, pyrrolizidines, and quinolizidines. (1993) (93)
Binding of alpha-and beta-adrenergic ligands to cerebral cortical membranes: effect of 6-hydroxydopamine treatment and relationship to the responsiveness of cyclic amp-generating systems in two rat strains. (1978) (92)
An activator of protein kinase C (phorbol‐12‐myristate‐13‐acetate) augments 2‐chloroadenosine‐elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations (1985) (92)
Forskolin, adenylate cyclase, and cell physiology: an overview. (1984) (91)
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. (1985) (91)
Locomotor activity in mice during chronic treatment with caffeine and withdrawal (1993) (91)
Oxygen-dependent reaction of 6-hydroxydopamine, 5,6-dihydroxytryptamine, and related compounds with proteins in vitro: a model for cytotoxicity. (1976) (90)
A study of the irreversible cholinesterase inhibitor, diisopropylfluorophosphate, on time course of end-plate currents in frog sartorius muscle. (1974) (90)
Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes. (1971) (90)
Membrane potential fluorescence: A rapid and highly sensitive assay for nicotinic receptor channel function (2003) (90)
Accumulations of Cyclic AMP in Adenine‐Labeled Cell‐free Preparations from Guinea Pig Cerebral Cortex: Role of α‐Adrenergic and H1‐Histaminergic Receptors (1980) (90)
Migration of deuterium during hydroxylation of aromatic substrates by liver microsomes. I. Influence of ring substitutents. (1968) (88)
Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds (1972) (87)
Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 2. Effects of depolarizing agents, membrane stabilizers, phosphodiesterase inhibitors, and adenosine analogs. (1972) (87)
Ernest Guenther award in chemistry of natural products. Amphibian skin: a remarkable source of biologically active arthropod alkaloids. (2003) (84)
The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker. (2004) (83)
Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor. (1977) (83)
Enzymatic p-O-Methylation by Catechol O-Methyl Transferase (1959) (82)
Injury to the ureter during gynecologic surgical procedures. (1988) (82)
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. (1993) (81)
Alkaloids from dendrobatid frogs: structures of two omega-hydroxy congeners of 3-butyl-5-propylindolizidine and occurrence of 2,5-disubstituted pyrrolidines and a 2,6-disubstituted piperidine. (1986) (81)
Species differences in structure‐activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors (1986) (80)
Formation of cyclic adenosine 3',5'-monophosphate from adenosine in brain slices. (1970) (80)
Alkaloids from a panamanian poison frog, Dendrobates speciosus: identification of pumiliotoxin-A and allopumiliotoxin class alkaloids, 3,5-disubstituted indolizidines, 5-substituted 8-methylindolizidines, and a 2-methyl-6-nonyl-4-hydroxypiperidine. (1988) (80)
Arthropod–Frog Connection: Decahydroquinoline and Pyrrolizidine Alkaloids Common to Microsympatric Myrmicine Ants and Dendrobatid Frogs (2004) (79)
The nature of receptors regulating the formation of cyclic AMP in brain tissue. (1976) (79)
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. (1985) (79)
Geographic and Seasonal Variation in Alkaloid-Based Chemical Defenses of Dendrobates pumilio from Bocas del Toro, Panama (2006) (79)
Structure-activity relationships for N6-substituted adenosines at a brain A1-adenosine receptor with a comparison to an A2-adenosine receptor regulating coronary blood flow. (1986) (78)
Cyclic adenosine 3',5'-monophosphate formation in brain slices: stimulation by batrachotoxin, ouabain, veratridine, and potassium ions. (1970) (78)
First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus. (1994) (78)
Further Alkaloids Common to Ants and Frogs: Decahydroquinolines and a Quinolizidine (1999) (78)
ADENOSINE RECEPTORS: TARGETS FOR FUTURE DRUGS (1982) (77)
Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine. (1997) (76)
A new class of indolizidine alkaloids from the poison frog, Dendrobates tricolor. X-ray analysis of 8-hydroxy-8-methyl-6-(2'-methylhexylidene)-1-azabicyclo[4.3.0]nonane (1980) (76)
The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. II. Synthesis of 3,4-toluene-4-2H oxide and subsequent "NIH shift" to 4-hydroxytoluene-3-2H. (1968) (75)
Alkaloids in Madagascan frogs (Mantella): pumiliotoxins, indolizidines, quinolizidines, and pyrrolizidines. (1993) (74)
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. (1989) (73)
Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations. Effects of norepinephrine, histamine, carbamylcholine and 2-chloroadenosine. (1985) (73)
Activation of rat cerebral cortical 3',5'-cyclic nucleotide phosphodiesterase activity by gangliosides. (1980) (73)
[3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors. (1986) (72)
Nuclear Magnetic Resonance Spectra of Indoles (1960) (71)
New classes of amidine, indolizidine and quinolizidine alkaloids from a poison-frog, dendrobates pumilio (dendrobatidae) (1987) (70)
Regulation of cyclic AMP formation in brain tissue by alpha-adrenergic receptors: requisite intermediacy of prostaglandins of the E series. (1980) (70)
Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current. (1974) (70)
Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor. (1981) (70)
Caffeine analogs: structure-activity relationships at adenosine receptors. (1991) (69)
The production of meta-chlorotyrosine from para-chlorophenylalanine by phenylalanine hydroxylase (1966) (69)
Evidence for biosynthesis of pseudophrynamine alkaloids by an Australian myobatrachid frog (pseudophryne) and for sequestration of dietary pumiliotoxins. (2002) (69)
Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. (1992) (68)
Steroidal alkaloids (batrachotoxins and 4β-hydroxybatrachotoxins), “indole alkaloids” (calycanthine and chimonanthine) and a piperidinyldipyridin (1983) (68)
Occurrence of skin alkaloids in non-dendrobatid frogs from Brazil (Bufonidae), Australia (Myobatrachidae) and Madagascar (Mantellinae). (1984) (68)
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. (2002) (68)
Allenic and acetylenic spiropiperidine alkaloids from the neotropical frog, Dendrobates histrionicus. (1974) (67)
The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines. (1966) (67)
Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates (2003) (67)
Batrachotoxin. The active principle of the Colombian arrow poison frog, Phyllobates bicolor. (1965) (66)
Chronic effects of a monoamine oxidase-inhibiting antidepressant: decreases in functional alpha-adrenergic autoreceptors precede the decrease in norepinephrine-stimulated cyclic adenosine 3': 5'- monophosphate systems in rat brain (1982) (65)
Formation of inositol phosphates in synaptoneurosomes of guinea pig brain: stimulatory effects of receptor agonists, sodium channel agents and sodium and calcium ionophores (1988) (65)
Metobolism of chlorobenzene with hepatic microsomes and solubilized cytochrome P-450 systems. (1975) (65)
Accumulation of adenosine cyclic 3',5'-monophosphate in rat cerebral cortical slices. Stimulatory effect of alpha and beta adrenergic agents after treatment with 6-hydroxydopamine, 2,3,5-trihydroxyphenethylamine, and dihydroxytryptamines. (1973) (65)
Adenosine receptors: development of selective agonists and antagonists. (1987) (64)
The structure of batrachotoxinin A, a novel steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia. (1968) (64)
The role of calcium ions in accumulation of cyclic adenosine monophosphate elicited by alpha and beta adrenergic agonists in rat brain slices. (1977) (64)
Chronic Effects of Xanthines on Levels of Central Receptors in Mice (1999) (63)
Actions of the histrionicotoxins at the ion channel of the nicotinic acetylcholine receptor and at the voltage-sensitive ion channels of muscle membranes. (1982) (63)
Effect of depolarizing agents on accumulation of cyclic adenosine 3',5'-monophosphate in cerebral cortical slices. (1972) (62)
Discovery of a defensively malodorous and nocturnal frog in the family Dendrobatidae : phylogenetic significance of a new genus and species from the Venezuelan Andes. American Museum novitates ; no. 3002 (1991) (62)
Rearrangement of (1- 2 H)- and (2- 2 H)naphthalene 1,2-oxides to 1-naphthol. Mechanism of the NIH shift. (1972) (61)
Stimulation of phosphoinositide breakdown in brain synaptoneurosomes by agents that activate sodium influx: antagonism by tetrodotoxin, saxitoxin, and cadmium. (1987) (60)
Cyclic adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices. II. The role of phosphodiesterase activity in the regulation of levels of cyclic adenosine 3',5'-monophosphate. (1973) (60)
Cyclic adenosine 3',5'monophosphate role in the physiology and pharmacology of the central nervous system. (1975) (59)
Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines. (1979) (59)
Norepinephrine-Sensitive Adenylate Cyclases in Rat Brain: Relation to Behavior and Tyrosine Hydroxylase (1974) (59)
Histamine‐elicited accumulations of cyclic adenosine 3′,5′‐monophosphate in guinea‐pig brain slices: Effect of H1‐ and H2‐antagonists (1975) (59)
Marine toxins and nonmarine toxins: convergence or symbiotic organisms? (2004) (59)
Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 1. Structure-activity relationships of agonists and antagonists of biogenic amines and of tricyclic tranquilizers and antidepressants. (1972) (59)
Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand. (2004) (58)
Regulation of adenosine cyclic 3',5'-phosphate formation in cerebral cortical slices. Interaction among norepinephrine, histamine, serotonin. (1971) (58)
Acetylcholine receptor and ionic channel of Torpedo electroplax: binding of perhydrohistrionicotoxin to membrane and solubilized preparations. (1978) (58)
A reconstituted microsomal enzyme system that converts naphthalene to trans-1,2-dihydroxy-1,2-dihydronaphthalene via naphthalene-1,2-oxide: presence of epoxide hydrase in cytochrome P-450 and P-448 fractions. (1972) (58)
Chapter One - Alkaloids from Amphibian Skins (1999) (57)
Accumulation of adenosine 3':5'-cyclic monophosphate in clonal glial cells: labeling of intracellular adenine nucleotides with radioactive adenine. (1972) (57)
Norepinephrine-Sensitive Systems Generating Adenosine 3',5'-Monophosphate: Increased Responses in Cerebral Cortical Slices from Reserpine-Treated Rats (1974) (57)
Absence of skin alkaloids in captive-raised Madagascan mantelline frogs (Mantella) and sequestration of dietary alkaloids. (1997) (57)
Enzymatic conversion of 5-tritiotryptophan to 4-tritio-5-hydroxytryptophan (1966) (57)
Patients with Malignant Hyperthermia Demonstrate an Altered Calcium Control Mechanism in B Lymphocytes (2002) (56)
Identification of 3,4-Dimethoxyphenethylamine from Schizophrenic Urine by Mass Spectrometry (1967) (56)
Variability in alkaloid profiles in neotropical poison frogs (Dendrobatidae): genetic versus environmental determinants. (1992) (56)
Alkaloids from dendrobatid poison frogs: trans-decahydroquinolines and indolizidines (1986) (56)
Cyclic adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices. 3. Formation, degradation, and reformation of cyclic adenosine 3',5'-monophosphate during sequential stimulations by biogenic amines and adenosine. (1973) (55)
Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse. (1972) (55)
Use of dansyl derivatives and mass spectrometry for identification of biogenic amines. (1968) (55)
Definition of subclasses of adenosine receptors associated with adenylate cyclase: interaction of adenosine analogs with inhibitory A1 receptors and stimulatory A2 receptors. (1987) (55)
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors. (1985) (54)
Alkaloids in Bufonid Toads (Melanophryniscus): Temporal and Geographic Determinants for Two Argentinian Species (2007) (54)
Accumulations of inositol phosphates and cyclic AMP in brain slices: synergistic interactions of histamine and 2-chloroadenosine. (1986) (54)
INTERRELATIONSHIPS AMONG THE LEVELS OF ATP, ADENOSINE AND CYCLIC AMP IN INCUBATED SLICES OF GUINEA‐PIG CEREBRAL CORTEX: EFFECTS OF DEPOLARIZING AGENTS, PSYCHOTROPIC DRUGS AND METABOLIC INHIBITORS (1974) (53)
Hydroxylation of alkyl and halogen substituted anilines and acetanilides by microsomal hydroxylases. (1968) (53)
The protein kinase C activator phorbol‐12‐myristate‐13‐acetate enhances cyclic AMP accumulation in pheochromocytoma cells (1986) (52)
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor. (2003) (52)
Characterization of the locomotor depression produced by an A2‐selective adenosine agonist (1990) (52)
Venom chemistry of the ant Myrmicaria melanogaster from Brunei. (2007) (52)
Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors. (1988) (52)
The role of adenosine receptors in the central action of caffeine. (2020) (51)
Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells. (1992) (51)
Adenosine receptor interactions and anxiolytics (1983) (51)
Migration of substituents during Hydroxylation of aromatic substrates (NIH shift). Oxidations with peroxytrifluoroacetic acid. (1971) (51)
Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers. (1995) (50)
Effects of histrionicotoxin on the chemosensitive and electrical properties of skeletal muscle (1975) (50)
Pharmacological activity of alkaloids from poison-dart frogs (Dendrobatidae). (1978) (50)
Stimulation of adenosine 3',5'-monophosphate formation by alpha and beta adrenergic agonists in rat cerebral cortical slices: effects of clonidine. (1975) (50)
An electrophysiological study of the effects of D-tubocurarine, atropine, and alpha-bungarotoxin on the cholinergic receptor in innervated and chronically denervated mammalian skeletal muscles. (1974) (50)
Purines. VI. The Preparation of Certain 6-Substituted-and 6,9-Disubstituted Purines (1956) (49)
Molecular probes for extracellular adenosine receptors. (1987) (49)
The antinociceptive effect of intrathecally administered adenosine analogs in mice correlates with the affinity for the A1-adenosine receptor (1991) (49)
Role of Cyclic Nucleotides in the Nervous System (1975) (49)
Madagascan poison frogs (Mantella) and their skin alkaloids / John W. Daly, Nirina Rabe Andriamaharavo, Marta Andriantsiferana, and Charles W. Myers. American Museum novitates ; no. 3177 (1996) (48)
INTRAMOLECULAR MIGRATION OF TRITIUM AND DEUTERIUM DURING NONENZYMATIC AROMATIC HYDROXYLATION. (1967) (48)
Retention of deuterium in p-tyrosine formed enzymatically from p-deuterophenylalanine. (1966) (48)
A functionalized congener approach to adenosine receptor antagonists: amino acid conjugates of 1,3-dipropylxanthine. (1986) (48)
Anti‐HIV‐1 limonoid: first isolation from Clausena excavata (2003) (48)
Chapter 39 – Chemistry and Pharmacology of Frog Venoms (1971) (47)
Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase. (1992) (47)
A common pumiliotoxin from poison frogs exhibits enantioselective toxicity against mosquitoes (2006) (47)
Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells. (1986) (47)
The formation, degradation, and function of cyclic nucleotides in the nervous system. (1977) (47)
A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F. (1992) (47)
Highly stereoselective construction of trans(2,3)-cis(2,6)-trisubstituted piperidines: An application to the chiral synthesis of Dendrobates alkaloids (1997) (47)
Membrane Potentials in Cell‐free Preparations from Guinea Pig Cerebral Cortex: Effect of Depolarizing Agents and Cyclic Nucleotides (1980) (46)
Caffeine: a model drug of abuse. (1990) (46)
Batrachotoxin, a Selective Probe for Channels Modulating Sodium Conductances in Electrogenic Membranes (1977) (46)
An arboreal poison frog (Dendrobates) from western Panama. (1984) (46)
Stimulation of adenosine 3',5'-monophosphate formation in rat cerebral cortical slices by methoxamine: interaction with an alpha adrenergic receptor. (1975) (46)
Ibogaine: a potent noncompetitive blocker of ganglionic/neuronal nicotinic receptors. (1997) (46)
Selective stimulation of Ca2+ flux in cells by maitotoxin. (1992) (45)
Multiple effects of caffeine on Ca2+ release and influx in human B lymphocytes. (2001) (45)
Depolarization-evoked accumulation of cyclic AMP in brain slices: inhibition by exogenous adenosine deaminase. (1973) (45)
The production of meta-tritiotyrosine from p-tritiophenylalanine by phenylalanine hydroxylase. (1966) (45)
Purines in cellular signaling : targets for new drugs (1990) (44)
Alkaloids of neotropical poison frogs (Dendrobatidae). (1982) (44)
CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE FORMATION IN GUINEA‐PIG BRAIN SLICES: EFFECT OF H1‐ AND H2‐HISTAMINERGIC AGONISTS (1976) (44)
Antinociceptive effects of the alkaloid epibatidine: Further studies on involvement of nicotinic receptors (1995) (44)
Alkaloids from Australian frogs (Myobatrachidae): pseudophrynamines and pumiliotoxins. (1990) (44)
Pseudophrynamine A: an unusual prenyl pyrrolo[2,3-b]indole ester from an Australian frog, Pseudophryne coriacea (Myobatrachidae) (1988) (44)
Absence of tetrodotoxins in a captive-raised riparian frog, Atelopus varius. (1997) (44)
Calmodulin stimulation of adenylate cyclase in rat brain membranes does not require GTP. (1982) (43)
Maitotoxin, a potent, general activator of phosphoinositide breakdown (1989) (43)
Accumulation of adenosine 3',5'-monophosphate in rat brain slices: effects of prostaglandins. (1975) (43)
Interactions of bupivacaine with ionic channels of the nicotinic receptor. Analysis of single-channel currents. (1984) (43)
Diethylstilbestrol-elicited accumulation of cyclic AMP in incubated rat hypothalamus. (1975) (43)
The effect of histamines and other compounds on the formation of adenosine 3′,5′‐monophosphate in slices from cerebral cortex (1970) (43)
Effects of chronic caffeine on adenosine, dopamine and acetylcholine systems in mice. (1994) (42)
Uptake and binding of dopamine and 6-hydroxydopamine in murine neuroblastoma and fibroblast cells. (1976) (42)
A role for central A3-adenosine receptorsMediation of behavioral depressant effects (1993) (42)
Phenolic antioxidants: potent inhibitors of the (Ca2+ + Mg2+‐ATPase of sarcoplasmic reticulum (1986) (42)
N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. (1991) (42)
Effect of membrane depolarization and biogenic amines on the formation of cyclic AMP in incubated brain slices. (1970) (41)
The use of thin-layer chromatography for the analysis of drugs. Isolation and identification of barbiturates and nonbarbiturate hypnotics from urine, blood and tissues. (1963) (41)
Effects of the amphiphilic peptides melittin and mastoparan on calcium influx, phosphoinositide breakdown and arachidonic acid release in rat pheochromocytoma PC12 cells. (1992) (41)
The synthesis of 2,4,5-trihydroxyphenylalanine (6-hydroxydopa). A centrally active norepinephrine-depleting agent. (1969) (41)
Glutamate- and veratridine-elicited accumulations of cyclic AMP in brain slices: a role for factors which potentiate adenosine-responsive systems (1980) (41)
Brain α-adrenergic receptors: comparison of [3H]WB 4101 binding with norepinephrine-stimulated cyclic AMP accumulation in rat cerebral cortex (1978) (41)
Alkylxanthines as research tools. (2000) (41)
A Siphonotid Millipede (Rhinotus) as the Source of Spiropyrrolizidine Oximes of Dendrobatid Frogs (2003) (41)
Synthesis of alkaloid 223A and a structural revision. (2002) (40)
Catechol O-Methyltransferase: III. m- and p-O-Methylation of Catecholamines and Their Metabolites (1970) (40)
Interrelationship between catecholamine-stimulated formation of adenosine 3',5'-monophosphate in cerebellar slices and inhibitory effects on cerebellar Purkinje cells: antagonism by neuroleptic compounds. (1976) (39)
The accumulation of cyclic AMP and cyclic GMP in guinea pig brain slices. Effect of calcium ions, norepinephrine and adenosine. (1977) (39)
Alkaloids from dendrobatid poison frogs: Further cis-decahydroquinolines and 8-methylindolizidines (1991) (39)
THE USE OF THIN-LAYER CHROMATOGRAPHY OF DRUGS. IDENTIFICATION AND ISOLATION TRANQUILIZERS AND OF ANTIHISTAMINICS IN TISSUES (1963) (39)
The migration of deuterium during aryl hydroxylation. II. Effect of induction of microsomal hydroxylases with phenobarbital or polycyclic aromatic hydrocarbons. (1969) (38)
Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus). (2008) (38)
Analogues of Adenosine, Theophylline, and Caffeine: Selective Interactions with A1 and A2 Adenosine Receptors (1987) (38)
A1- and A2-selective adenosine antagonists: in vivo characterization of cardiovascular effects. (1987) (37)
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. (1988) (37)
Catechol O-methyltransferase. 3. M- and p-O-methylation of catecholamines and their metabolites. (1970) (36)
Arene Oxides‐Oxepins (1973) (36)
Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. (1993) (36)
Dihydroxytryptamines: effects on noradrenergic function in mouse heart in vivo. (1975) (36)
Sciatic and peroneal nerve injury: a complication of vaginal operations. (1967) (36)
Assay and partial purification of epoxide hydrase from rat liver microsomes. (1974) (36)
Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi. (2010) (36)
Chemical and Enzymatic Routes to Methoxydopamines (1961) (36)
Adenosine Receptors:Selective Agonists and Antagonists (1995) (36)
Alkaloids of Anuran Skin: Antimicrobial Function? (2005) (35)
Hydroxylation-induced migrations of tritium in several substrates of liver aryl hydroxylases. (1967) (35)
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. (1989) (35)
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors. (1993) (35)
Loperamide: a positive modulator for store-operated calcium channels? (1997) (35)
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists. (1990) (35)
A stereospecific synthesis of (+/-)-5,8-disubstituted indolizidines and (+/-)-1,4-disubstituted quinolizidines found in poison frog skins. (2000) (34)
Deuterium migration during the acid-catalyzed dehydration of 6-deuterio-5,6-dihydroxy-3-chloro-1,3-cyclohexadi-ene, a nonenzymic model for the NIH shift (1967) (34)
Interaction of clonidine with pre- and post-synaptic adrenergic receptors of rat brain: effects on cyclic AMP-generating systems. (1976) (34)
Inhibitors of norepinephrine metabolism in vivo. (1959) (34)
Arene oxides as intermediates in the metabolism of aromatic substrates: alkyl and oxygen migrations during isomerization of alkylated arene oxides. (1971) (34)
Epiquinamide: a poison that wasn't from a frog that was. (2009) (33)
Interaction of gephyrotoxin and indolizidine alkaloids with the nicotinic acetylcholine receptorion channel complex of torpedo electroplax (1986) (33)
Macromolecular sites for specific neurotoxins and drugs on chemosensitive synapses and electrical excitation in biological membranes. (1988) (33)
METHYLATION AND DEMETHYLATION IN RELATION TO THE IN VITRO METABOLISM OF MESCALINE (1962) (33)
Pumiliotoxin B binds to a site on the voltage-dependent sodium channel that is allosterically coupled to other binding sites. (1988) (33)
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. (2005) (32)
The pharmacology of batrachotoxin. VII. Structure-activity relationships and the effects of pH. (1975) (32)
Maitotoxin: effects on calcium channels, phosphoinositide breakdown, and arachidonate release in pheochromocytoma PC12 cells. (1990) (32)
Quantitative studies on the hydroxylation-induced migration of deuterium and tritium during phenylalanine hydroxylation. (1967) (32)
N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide. (2008) (32)
Altered responsiveness of adenosine 3′,5′-monophosphate-generating systems in rat cortical slices after lesions of the medial forebrain bundle (1975) (32)
Epibatidine: A Novel (Chloropyridyl)azabicycloheptane with Potent Analgesic Activity from an Ecuadoran Poison Frog. (1992) (32)
Production of m-methyltyrosine and p-hydroxymethylphenylalanine from p-methylphenylalanine by phenylalanine hydroxylase. (1968) (32)
Migration of deuterium during aryl hydroxylation. 3. Effect of ortho- and meta- substituents. (1969) (32)
Phospholipase D-catalyzed hydrolysis of phosphatidylcholine occurs with P-O bond cleavage. (1991) (32)
Skin as a Toxin Storage Organ in the Endemic New Guinean Genus Pitohui (2009) (32)
Photolysis of pyridine-N-oxide: an oxygen atom transfer model for enzymatic oxygenation, arene oxide formation, and the NIH shift (1970) (32)
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors. (1986) (31)
Caffeine Analogs: Effects on Ryanodine-Sensitive Calcium-Release Channels and GABAA Receptors (2003) (31)
1980 Taxonomy and Ecology of Dendrobates bombetes , a New Andean Poison Frog With New Skin Toxins (31)
Chemistry of Catecholamines: Revised Structures for the Iodoaminochromes (1963) (31)
Optically active 1,2-naphthalene oxide (1970) (30)
Catechol-O-methyltransferase. I. An enzymatic assay for cardiac norepinephrine. (1969) (30)
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. (1998) (30)
Individual and Geographic Variation of Skin Alkaloids in Three Species of Madagascan Poison Frogs (Mantella) (2008) (30)
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities. (2000) (30)
A [3H]amine congener of 1,3‐dipropyl‐8‐phenylxanthine (1986) (30)
N-methyldecahydroquinolines: an unexpected class of alkaloids from Amazonian poison frogs (Dendrobatidae). (2009) (30)
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. (1986) (29)
Nicotinic receptor-elicited sodium flux in rat pheochromocytoma PC12 cells: Effects of agonists, antagonists, and noncompetitive blockers (1991) (29)
The pharmacology of pumiliotoxin-B. I. Interaction with calcium sites in the sarcoplasmic reticulum of skeletal muscle. (1981) (29)
Pumiliotoxin alkaloids: a new class of sodium channel agents. (1990) (29)
Synthesis and adrenergic activity of ring-fluorinated phenylephrines. (1986) (28)
Intramolecular migration of deuterium and tritium during enzymic hydroxylation of p-deuteroacetanilide and p-tritioacetanilide. (1967) (28)
Calcium-dependent effects of maitotoxin on phosphoinositide breakdown and on cyclic AMP accumulation in PC12 and NCB-20 cells. (1989) (28)
Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene. (1973) (28)
Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms. (1991) (28)
Aerobic aromatic hydroxylation catalyzed by horseradish peroxidase: absense of NIH shift. (1970) (28)
Structure of alkaloid 275A, a novel 1-azabicyclo[5.3.0]decane from a dendrobatid frog, Dendrobates lehmanni: synthesis of the tetrahydrodiastereomers. (2001) (27)
Multiple neurotransmitter receptors in the brain: amines, adenosine, and cholecystokinin. (1981) (27)
A new class of cardiotonic agents: structure-activity correlations for natural and synthetic analogues of the alkaloid A new class of A new class of cardiotonic agents: structure-activity correlations for natural and synthetic analogues of the alkaloid pumiliotoxin B (8-hydroxy-8-methyl-6-alkylidene (1985) (27)
The pharmacology of batrachotoxin. V. A comparative study of membrane properties and the effect of batrachotoxin on sartorius muscles of the frogs Phyllobates aurotaenia and Rana pipiens. (1973) (27)
β-Adrenergic-control of cyclic AMP-generating systems in cerebellum: Pharmacological heterogeneity confirmed by destruction of interneurons (1976) (27)
Rapid analysis of tryptophan hydroxylase in rat tissue using 5- 3 H-tryptophan. (1971) (27)
Evidence That a Novel 8‐Phenyl‐Substituted Xanthine Derivative is a Cardioselective Adenosine Receptor Antagonist In Vivo (1987) (26)
Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells: role of calcium uptake and phosphoinositide breakdown. (1990) (26)
Decahydroquinoline alkaloids: Noncompetitive blockers for nicotinic acetylcholine receptor-channels in pheochromocytoma cells andTorpedo electroplax (1991) (26)
On the inability of tryptamine to serve as a precursor of serotonin. (1959) (25)
Isotope studies on the mechanism of action of adrenal tyrosine hydroxylase. (1968) (25)
Inhibition of platelet aggregation by adenosine receptor agonists (1994) (25)
Effect of batrachotoxin on the electroplax of electric eel: evidence for voltage-dependent interaction with sodium channels. (1977) (25)
Binding of [3H]perhydrohistrionicotoxin and [3H]phencyclidine to the nicotinic receptor-ion channel complex of Torpedo electroplax. Inhibition by histrionicotoxins and derivatives. (1985) (25)
Alkaloid 223A: the first trisubstituted indolizidine from dendrobatid frogs. (1997) (25)
Pumiliotoxin alkaloids: relationship of cardiotonic activity to sodium channel activity and phosphatidylinositol turnover. (1988) (24)
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors. (2007) (24)
Localization of glutamate decarboxylase on line-immunoelectrophoresis and two-dimensional electrophoresis by use of the radioactive suicide substrate [2-3H]-gamma-acetylenic GABA. (1980) (24)
Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig. (1991) (24)
Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants. (1990) (24)
Interactions of bupivacaine with ionic channels of the nicotinic receptor. Electrophysiological and biochemical studies. (1984) (24)
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC). (1989) (24)
Mechanism of maitotoxin-stimulated phosphoinositide breakdown in HL-60 cells. (1990) (24)
A new subclass of alkaloids from a dendrobatid poison frog: a structure for deoxypumiliotoxin 251H. (1995) (23)
Regulation of cyclic AMP levels in brain tissue. (1972) (23)
Effect of calmidazolium analogs on calcium influx in HL-60 cells. (2000) (23)
Interactions of gephyrotoxin with the acetylcholine receptor-ionic channel complex. I. Blockade of the ionic channel. (1984) (23)
Mesoionic xanthine analogues: antagonists of adenosine receptors. (1984) (23)
(3H)BATRACHOTOXININ A 20α-BENZOATE BINDING TO VOLTAGE-SENSITIVE SODIUM CHANNELS: A RAPID AND QUANITATIVE ASSAY FOR LOCAL ANESTHETIC ACTIVITY IN A VARIETY OF DRUGS (1985) (23)
The "pink spot," 3,4-dimethoxyphenylethylamine, common tea, and schizophrenia. (1970) (23)
The enantioselective synthesis of poison-frog alkaloids (−)-203A, (−)-209B, (−)-231C, (−)-233D, and (−)-235B″ (2006) (23)
Effect of proteases and protease inhibitors on adenylate cyclase activity in rat cerebral cortical membranes. (1979) (22)
Interaction of pumiliotoxin B with an "alkaloid-binding domain" on the voltage-dependent sodium channel. (1992) (22)
Cone biopsy: an outpatient procedure. (1980) (22)
Syntheses and adrenergic activities of ring-fluorinated epinephrines. (1988) (22)
Pumiliotoxin-C and synthetic analogues. A new class of nicotinic antagonists. (1982) (22)
Recent Studies on the Centrally Active Endogenous Amines (1963) (22)
Chronic effects of ethanol on central adenosine function of mice (1994) (22)
Calcium-dependent 3':5'-cyclic nucleotide phosphodiesterase. Inhibition of basal activity at physiological levels of potassium ions. (1978) (22)
Local anesthetics differentiate dihydropyridine calcium antagonist binding sites in rat brain and cardiac membranes. (1987) (22)
A name for the poison frog of Cordillera Azul, eastern Peru, with notes on its biology and skin toxins (Dendrobatidae). American Museum novitates ; no. 2674 (1979) (22)
The binding of fluorocatecholamines to adrenergic and dopaminergic receptors in rat brain membranes. (1980) (22)
Isomers of 2,4,5-trihydroxyphenethylamine (6-hydroxydopamine): long-term effects on the accumulation of (3H)-norepinephrine in mouse heart in vivo. (1973) (21)
Stimulation of calcium release by caffeine analogs in pheochromocytoma cells. (1993) (21)
Treatment of Vaginal Dysplasia and Carcinoma In Situ with Topical 5‐Fluorouracil (1980) (21)
Loperamide: novel effects on capacitative calcium influx (2000) (21)
A simple radiometric assay for microsomal aryl hydroxylase activity. (1970) (21)
Differential effects of maitotoxin on ATP secretion and on phosphoinositide breakdown in rat pheochromocytoma cells (1988) (21)
Effects of mastoparan and related peptides on phosphoinositide breakdown in HL-60 cells and cell-free preparations. (1991) (21)
Contact toxicities of anuran skin alkaloids against the fire ant (Solenopsis invicta) (2013) (21)
Adenosine Receptors in the Central Nervous System: Structure-Activity Relationships for Agonists and Antagonists (1985) (20)
Accumulation of adenosine 3′,5′‐monophosphate in incubated slices from discrete regions of squirrel monkey cerebral cortex: effect of norepinephrine, serotonin and adenosine (1973) (20)
Taxonomy and ecology of Dendrobates bombetes, a new Andean poison frog with new skin toxins. American Museum novitates ; no. 2692 (1980) (20)
8-Substituted xanthines as antagonists at A1- and A2-adenosine receptors. (1988) (20)
Cis- and trans-configurations of α,α′-disubstituted piperidines and pyrrolidines by GC-FTIR; application to decahydroquinoline stereochemistry (1994) (20)
Discovery of the Costa Rican poison frog Dendrobates granuliferus in sympatry with Dendrobates pumilio, and comments on taxonomic use of skin alkaloids. American Museum novitates ; no. 3144 (1995) (20)
Sabinene Hydrate: a Constituent of American Peppermint Oil1 (1958) (20)
A SURVEY OF NONXANTHINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS. (1996) (20)
Neurochemical and behavioral effects of clonidine and related imidazolines: interaction with alpha-adrenoceptors. (1978) (20)
The effects of batrachotoxin on cat papillary muscle. (1976) (20)
Identification of histrionicotoxins by GC-MS and GC-FTIR: Photo- and chemical-artefacts and revised 13C NMR assignments (1992) (20)
The metabolism of hydroxychlorpromazines by rat liver microsomes. (1967) (20)
5,8-Disubstituted indolizidines: A new class of noncompetitive blockers for nicotinic receptor-channels (1991) (20)
Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B. (2009) (19)
Selective exchange of nuclear protons in hydroxyindoles. (1967) (19)
Flexible synthetic routes to poison-frog alkaloids of the 5,8-disubstituted indolizidine-class I: synthesis of common lactam chiral building blocks and application to the synthesis of (-)-203A, (-)-205A, and (-)-219F (2007) (19)
A novel 8-phenyl-substituted xanthine derivative is a selective antagonist at adenosine A1-receptors in vivo. (1985) (19)
Imidazodiazepinediones: a new class of adenosine receptor antagonists. (1990) (19)
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. (1991) (19)
Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines. (1980) (19)
Methylxanthines block antigen-induced responses in RBL-2H3 cells independently of adenosine receptors or cyclic AMP: evidence for inhibition of antigen binding to IgE. (1991) (19)
The pharmacology of batrachotoxin. VI. Effects on the mammalian motor nerve terminal. (1974) (19)
Calcium ion-elicited accumulations of cyclic GMP in guinea pig cerebellar slices. (1977) (19)
Bis(monoacylglycero)phosphate from PC12 cells, a phospholipid that can comigrate with phosphatidic acid: molecular species analysis by fast atom bombardment mass spectrometry. (1992) (19)
Local anesthetics: comparison of effects on batrachotoxin-elicited sodium flux and phosphoinositide breakdown in guinea pig cerebral cortical synaptoneurosomes. (1988) (18)
Cyclic AMP‐Generating Systems in Cell‐Free Preparations from Guinea Pig Cerebral Cortex: Loss of Adenosine and Amine Responsiveness Due to Low Levels of Endogenous Adenosine (1980) (18)
Xanthine functionalized congeners as potent ligands at A2-adenosine receptors. (1987) (18)
Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. (1982) (18)
[Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine]. (1998) (18)
Probing the adenosine receptor with adenosine and xanthine biotin conjugates (1985) (18)
Cardiotonic activities of pumiliotoxin B, pyrethroids and a phorbol ester and their relationships with phosphatidylinositol turnover. (1987) (18)
Pharmacology of the alkaloid pumiliotoxin-B. II. Possible involvement of calcium and sodium-dependent processes in nerve and skeletal muscle. (1987) (18)
Effect of forskolin on alterations of vascular permeability induced with bradykinin, prostaglandin E1, adenosine, histamine and carrageenin in rats. (1983) (17)
Assay of enzymes of catecholamine biosynthesis and metabolism. (1971) (17)
Release of norepinephrine and dopamine from brain vesicular preparations: Effects of adenosine analogues (1982) (17)
pumiliotoxins: magnetic resonance spectral assignments and structural definition of pumiliotoxins A and B and related allopumiliotoxins (1984) (17)
Enantioselective syntheses of two 5, 9E diastereomers of 223V, an alkaloid from the poison frog Dendrobates pumilio (2005) (17)
Synthesis and Metabolism of 6-Hydroxycatecholamines* (1965) (17)
Homoepiboxidines: further potent agonists for nicotinic receptors. (2004) (17)
Metabolism of acetanilide with hepatic microsomes and reconstituted cytochrome monoxygenase systems. (1974) (17)
Spiropyrrolizidines: a new class of blockers of nicotinic receptors. (1996) (17)
Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. (2000) (17)
Inhibitors of store‐operated calcium channels: Imidazoles, phenothiazines, and other tricyclics (1999) (17)
Autoradiographic localization of mouse brain adenosine receptors with an antagonist ([3H]xanthine amine congener) ligand probe (1988) (17)
Activation of phosphoinositide breakdown and elevation of intracellular calcium in a rat RBL‐2H3 mast cell line by adenosine analogs: Involvement of A3‐adenosine receptors? (1996) (17)
Accumulations of cyclic AMP and inositol phosphates in guinea pig cerebral cortical synaptoneurosomes: enhancement by agents acting at sodium channels. (1986) (16)
Altered responsiveness of adenosine 3′,5′-monophosphate-generating systems in brain slices from adult rats after neonatal treatment with 6-hydroxydopamine (1975) (16)
Purines in Cellular Signaling (1990) (16)
Biologically Active Alkaloids from Poison Frogs (Dendrobatidae) (1982) (16)
The ionic channel of the acetylcholine receptor. Regulation by sites outside and inside the cell membrane which are sensitive to quaternary ligands. (1981) (16)
A new species of poison frog lDendrobates r from Andean Ecuadorc including an analysis of its skin toxins (1976) (16)
Mouse β-TC6 Insulinoma Cells: High Expression of Functional α3β4 Nicotinic Receptors Mediating Membrane Potential, Intracellular Calcium, and Insulin Release (2006) (16)
Purine Functionalized Congeners as Molecular Probes for Adenosine Receptors (1991) (16)
Mechanism of aromatic hydroxylation in fungi. Evidence for the formation of arene oxides. (1976) (16)
Degeneration of CA1 neurons in hippocampus after ischemia in Mongolian gerbils: Cyclic AMP-systems (1983) (16)
Facile Synthesis of 4-Piperidones by Condensation of an α,β-Unsaturated Ketone, an Aldehyde and Ammonia: Synthesis of the Dendrobatid Frog Alkaloid 241D (1994) (16)
Enantioselective syntheses of poison-frog alkaloids : 219F and 221I and an epimer of 193E (2006) (16)
Effects of combinations of methylxanthines and adenosine analogs on locomotor activity in control and chronic caffeine‐treated mice (1993) (16)
Histrionicotoxins : Carbon-13 magnetic resonance spectral assignments and structural definition of further alkaloids from poison frogs (dendrobatidae) (1983) (16)
Interactions of gephyrotoxin with the acetylcholine receptor-ionic channel complex. II. Enhancement of desensitization. (1984) (16)
1-Isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices. (1979) (15)
Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats. (2010) (15)
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists. (1996) (15)
A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog (Mantella). (1996) (15)
The Preparation and Properties of Certain 2- and 4-Chloro Substituted Pteridines1 (1956) (15)
Purification of calcium-dependent phosphodiesterases from rat cerebrum by affinity chromatography on activator protein-sepharose. (1977) (15)
Intramolecular Migrations during Hydroxylation of Aromatic Compounds: The NIH Shift (1968) (15)
7-Deaza-9-phenyladenines. A new class of adenosine receptor antagonists. (1988) (15)
Sulfur analogs of dopamine and norepinephrine. Inhibition of catechol-O-methyltransferase. (1972) (14)
Enzymatic hydration of 8,9-indan oxide, Homoallylic addition of water. (1970) (14)
Adenosine Agonists and Antagonists (1990) (14)
Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx (1994) (14)
A simple direct assay of 3',5'-cyclic nucleotide phosphodiesterase activity based on the use of polyacrylamide-bononate affinity gel chromatography. (1979) (14)
Modulation of forskolin binding to rat brain membranes. (1985) (14)
The depletion of cardiac norepinephrine by 3,5-dihydroxy-4-methoxyphenethylamine and related compounds. (1967) (14)
Chapter 3 Amphibian Alkaloids (1993) (14)
The chemorelease of norepinephrine in mouse hearts. Structure-activity relationships. II. Drugs affecting the sympathetic and central nervous systems. (1966) (14)
Adenosine analogs with covalently attached lipids have enhanced potency at A1‐adenosine receptors (1987) (14)
Release of norepinephrine from brain vesicular preparations: Effects of an adenylate cyclase activator, forskolin, and a phosphodiesterase inhibitor (1982) (14)
Effect of maitotoxin analogues on calcium influx and phosphoinositide breakdown in cultured cells. (1991) (14)
Activation and desensitization of rat A3‐adenosine receptors by selective adenosine derivatives and xanthine‐7‐ribosides (1998) (13)
Mechanisms of regulation of neuronal sensitivity. (1980) (13)
Inhibition of receptor-mediated stimulation of cyclic AMP accumulation in neuroblastoma-hybrid NCB-20 cells by a phorbol ester. (1987) (13)
First Enantioselective Synthesisof a Hydroxyindolizidine Alkaloid from the Ant Myrmicariamelanogaster (2008) (13)
The structure of solaphyllidine, a novel 4-ketosteroidal alkaloid. (1970) (13)
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors. (1987) (13)
2, 3-cis-3, 4-trans-3, 4-Dihydroxy-L-proline: Mass Spectrometry and X-ray Analysis (1969) (13)
Functional and Phylogenetic Diversity of BSH and PVA Enzymes (2021) (13)
Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors (2007) (13)
Biosynthesis of cholesterol and cholesterol acetate in dendrobatid arrow poison frogs. (1971) (13)
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. (1988) (13)
Formation of phenols from aromatic substrates by plant and animal mono-oxygenases: the effect of adjacent deuteriums on the magnitude of the NIH shift of tritium. (1973) (13)
The structure of the side chain of the frog alkaloid pumiliotoxin B (1982) (13)
The synthesis of dehydrobufotenine. (1967) (13)
Enzymic and nonenzymic hydroxylation and chlorination of p-deuteroanisole. (1968) (13)
Combination of 5‐Fluorouracil and Radiation as Primary Therapy of Carcinoma of the Cervix (1968) (12)
Norepinephrine depletion and responsiveness of norepinephrine-sensitive cyclic AMP generating systems in guinea pig brain (1976) (12)
Chronic NMDA receptor stimulation: therapeutic implications of its effect on adenosine A1 receptors. (1995) (12)
Brain alpha-adrenergic receptors: comparison of [3H]WB 4101 binding with norepinephrine-stimulated cyclic AMP accumulation in rat cerebral cortex. (1978) (12)
Infectious morbidity associated with pelvic exenteration. (1980) (12)
Batrachotoxin, an extremely active cardio- and neurotoxin from the Colombian arrow poison frog Phyllobates aurotaenia. (1971) (12)
Mechanisms of Action of Caffeine on the Nervous System (2004) (12)
Behavioral activity and accumulation of cyclic AMP in brain slices of strains of mice. (1976) (12)
Determination of absolute stereochemistry and an alternative synthesis of homopumiliotoxin 223G: identification on chiral GC columns with the natural alkaloid. (2000) (12)
Pyrethroids: involvement of sodium channels in effects on inositol phosphate formation in guinea pig synaptoneurosomes (1989) (11)
The accumulation of adenosine 3',5'-monophosphate in cerebral cortical slices of the quaking mouse, a neurologic mutant. (1974) (11)
A Structure for 261C, a Novel Tricylic Alkaloid from the Madagascan Poison Frog, Mantella betsileo (2003) (11)
N6-cyclohexyladenosine and 1,3-diethyl-8-phenylxanthine label two distinct adenosine receptors in brain membranes (1980) (11)
Pharmacology of Caffeine (1998) (11)
Antagonism of α- and β-adrenergic-mediated accumulations of cyclic AMP in rat cerebral cortical slices by the β-antagonist (−)alprenolol (1976) (11)
Norepinephrine uptake sites in cardiac tissue. Lack of affinity of 6-hydroxynorepinephrine and related compounds. (1975) (11)
Local anesthetic properties of opioids and phencyclidines: Interaction with the voltage-dependent, batrachotoxin binding site in sodium channels (1985) (11)
Strain differences in responsiveness of norepinephrine-sensitive adenosine 3',5'-monophosphate-generating systems in rat brain slices after intraventricular administration of 6-hydroxydopamine. (1977) (11)
High-affinity binding of forskolin to rat brain membranes. (1985) (11)
Alkaloids from frog skins: selective probes for ion channels and nicotinic receptors. (1995) (11)
Batrachotoxinin-A 20-α-benzoate: A new radioactive ligand for voltage sensitive sodium channels (1981) (11)
"Living cytology" in the diagnosis of intraabdominal adenocarcinoma. (1975) (10)
GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. (1986) (10)
Pseudophrynaminol: a potent noncompetitive blocker of nicotinic receptor-channels. (1997) (10)
Pyrrolizidine oximes: a novel new class of dendrobatid alkaloids (1992) (10)
The combined use of alpha-methyltyrosine and threo-dihydroxyphenylserine--selective reduction of dopamine levels in the central nervous system. (1968) (10)
Effects of ATP and UTP in pheochromocytoma PC12 cells: Evidence for the presence of three P2 receptors, only one of which subserves stimulation of norepinephrine release (1994) (10)
Acute treatment of mice with high doses of caffeine: An animal model for choreiform movement (1993) (10)
Synthesis of pyrrolizidine oximes 222 and 236: Novel alkaloids of a dendrobatid poison frog (1994) (10)
Adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices: effects of alpha- and beta-adrenergic agents, histamine, serotonin and adenosine. (1973) (10)
Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. (2004) (10)
The action of catechol-o-methyltransferase on 7,8-dihydroxychlorpromazine--formation of 7-hydroxy-8-methoxychlorpromazine and 8-hydroxy-7-methoxychlorpromazine. (1969) (10)
Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release. (2006) (10)
Labilization of Ester Bonds in Aminocyclitol Derivatives. II. Polyacetates of Deoxystreptamine1 (1960) (10)
The depletion of norepinephrine-3H from heart by alpha-methyl-m-tyrosine. A novel and convenient method for assaying the inhibition of aromatic amino acid decarboxylase in vivo. (1966) (10)
Alkaloids from dendrobatid poison frogs: Further pumiliotoxins and allopumiliotoxins and a reassignment of the keto function in pumiliotoxin 307F (1991) (10)
Pyrazolopyridines: Effect of structural alterations on activity at adenosine‐ and GABAA‐receptors (1997) (10)
Inhibition of N6‐[3H]Cyclohexyladenosine Binding by Carbamazepine (1990) (9)
The absolute configuration of the side chain diol moiety of the poison-frog alkaloid pumiliotoxin B (1982) (9)
Chapter 4 The Nature and Origin of Amphibian Alkaloids (1998) (9)
Release of norepinephrine and dopamine from brain vesicular preparations: Effects of calcium antagonists (1982) (9)
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol. (1991) (9)
STRUCTURE–ACTIVITY CORRELATIONS IN TRIHYDROXYPHENETHYLAMINES AND DIHYDROXYTRYPTAMINES RELATIONSHIP TO CYTOTOXICITY IN ADRENERGIC AND SEROTONERGIC NEURONS (1974) (9)
Syntheses of the Proposed Structures of Poison-Frog Alkaloids 179 and 207E and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors (2008) (9)
Calcium-dependent cyclic nucleotide phosphodiesterase. Inhibition of basal activity by heat-stable factors from rat cerebrum. (1979) (9)
Ammonia chemical ionization tandem mass spectrometry in structure determination of alkaloids. I. Pyrrolidines, piperidines, decahydroquinolines, pyrrolizidines, indolizidines, quinolizidines and an azabicyclo[5.3.0]decane. (1999) (9)
A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar. (2005) (9)
[260] The use of dansyl derivatives for the identification and quantitation of amines (1971) (9)
Pseudosarcomatous fasciitis of the vulva. (1981) (9)
Ammonia chemical ionization tandem mass spectrometry in structural determination of alkaloids. II. Tetraponerines from pseudomyrmecine ants. (2001) (9)
The role of calcium in the regulation of cyclic nucleotide levels in brain slices of rat and guinea pig (1978) (9)
The chemorelease of norepinephrine from mouse hearts. IV. Structure-activity relationships. Reserpines and yohimbines. (1968) (9)
Dehiscence, evisceration, and other complications. (1988) (9)
Accumulation of Cyclic Nucleotides (1977) (8)
Phosphorimaging detection and quantitation for isotopic ion flux assays. (2005) (8)
General methods for the preparation of deuterium and tritium‐labelled phenethylamines and phenethanollamines: Synthesis of radioactive 6‐hydroxydopamine (1975) (8)
The synthesis of O-methylnordehydrobufotenine, a new psychoactive indole. (1969) (8)
Interactions of piperidine derivatives with the nicotinic cholinergic receptor complex from Torpedo electric organ (1988) (8)
Acummulation of cyclic adenosine 3', 5'-monophosphate in cerebral cortical slices from rat and mouse: stimulatory effect of alpha- and beta-adrenergic agents and adenosine. (1973) (8)
Caste-specific tyramides from Myrmicine ants. (2010) (8)
A naturally occurring erythro diastereomer of pumiliotoxin b (1988) (8)
The venoms of amphibians. (1966) (7)
Intracellular formation of analogs of cyclic AMP. Studies with brain slices labeled with radioactive derivatives of adenine and adenosine. (1975) (7)
The Synthesis and Properties of N,N-Dialkylaminovinylindoles (1962) (7)
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. (2000) (7)
Tropical poison frogs. (1993) (7)
The spontaneous occurrence of progressive synergistic bacterial gangrene on the abdominal wall. (1978) (7)
Antagonism of carbamylcholine-induced depolarization by batrachotoxin and veratridine. (1978) (7)
Enantioselective Synthesis of Poison-Frog Alkaloid 237D and Determination of Absolute Stereochemistry (2005) (7)
The synthesis and metabolism of 2,3-dihydro-L-tryptophan and 2,3-dihydro-5-hydroxy-DL-tryptophan. (1967) (7)
The structure of gephyrotoxin (GTX) 223AB (1981) (7)
Calcium‐dependent Desensitization of Adenylate Cyclase in Rat Cerebral Cortical Slices (1980) (7)
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity. (1993) (7)
Inhibition of Calcium‐Dependent ATPase from Sarcoplasmic Reticulum by a New Class of Indolizidine Alkaloids, Pumiliotoxins A, B, and 251D (1982) (7)
The husbandry and care of dendrobatid frogs. (2005) (7)
N6-functionalized congeners of adenosine with high potency at A2-adenosine receptors: potential ligands for affinity chromatography. (1986) (6)
Local anesthetics: stimulation of incorporation of inositol into phosphoinositides in guinea pig cerebral cortical synaptoneurosomes. (1990) (6)
Co-existence of muscarinic and nicotinic receptors and their functional interaction in mouse Beta-TC6 cells. (2009) (6)
7,8‐Dioxochlorpromazine, synthesis and properties (1975) (6)
Formation of second messengers in response to activation of ion channels in excitable cells (1988) (6)
The use of thin-layer chromatography for the analysis of drugs. Identification and isolation of phenothiazine tranquilizers and of antihistaminics in body fluids and tissues. (1963) (6)
Partial structures and binding studies of maitotoxin, the most potent marine toxin. (1992) (6)
Effects of forskolin and analogues on nicotinic receptor-mediated sodium flux, voltage-dependent calcium flux, and voltage-dependent rubidium efflux in pheochromocytoma PC12 cells (1990) (5)
Store-operated calcium channels in HL-60 cells effects of temperature, differentiation and loperamide. (2000) (5)
Blockade of central beta-adrenergic receptors by tazolol (1-isopropylamino-3-(2-thiazoloxy)-2-propanol). (1977) (5)
Histrionicotoxins: Effects on binding of radioligands for sodium, potassium, and calcium channels in brain membranes (1986) (5)
Procaine isothiocyanate: An irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels (1990) (5)
Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier (1969) (5)
Adaptive responses of brain cyclic AMP-generating systems to alterations in synaptic input. (1976) (5)
A NEW CLASS OF CARDIOTONIC AGENTS: STRUCTURE-ACTIVITY CORRELATIONS FOR NATURAL AND SYNTHETIC ANALOGS OF THE ALKALOID PUMILIOTOXIN (8-HYDROXY-8-METHYL-6-ALKYLIDENE-1-AZABICYCLO(4.3.0)NONANES) (1985) (5)
The Isolation and Structure of the Novel cis-Fused Indolizidine 249H from Frog Skin: cis- vs. trans-Fused Indolizidines Distinguished by NMR (1998) (5)
Binding of Radioactive Ligands to Adenosine Receptors in the Central Nervous System (1983) (5)
The sodium channel in membranes of electroplax. Binding of batrachotoxinin-a [3H]benzoate to particulate preparations from electric eel (electrophorus) (1986) (5)
Crystal and molecular structure of cis-2-isopropyl-3-(4-nitrophenyl)-oxaziridine (1972) (5)
Batrachotoxinin-A 20-alpha-benzoate: a new radioactive ligand for voltage sensitive sodium channels. (1981) (4)
Interaction of batrachotoxinin-A benzoate with voltage-sensitive sodium channels: The effects of pH (1981) (4)
THE ISOLATION AND STRUCTURE OF PUMILIOTOXIN 341A : A NOVEL CYCLIC ETHER FROM THE FROG EPIPEDOBA TES TRICOLOR (1999) (4)
Effects of forskolin analogs, phosphodiesterase inhibitors and 8-bromo cyclic AMP on plasma exudations induced with bradykinin and prostaglandin E1 in rat skin. (1984) (4)
Voltage-dependent sodium channels in synaptoneurosomes: studies with22Na+ influx and [3H]saxitoxin and [3H]batrachotoxinin-A 20-α-benzoate binding. Effects of proparacaine isothiocyanate (1990) (4)
Rapid identification of analgesic drugs in urine with thin-layer chromatography (1962) (4)
Batrachotoxinin A [3H]Benzoate Binding to Sodium Channels (1992) (4)
Biodiversity of Alkaloids in Amphibian Skin: A Dietary Arthropod Source (1999) (4)
Dioicine: A Novel Prenylated Purine Alkaloid from Gymnocladus dioicus (2009) (4)
Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. (1985) (4)
Adenosine analogs: potentiation of bradykinin-induced plasma exudation in rat skin and prevention by caffeine and theophylline. (1984) (4)
Separation of the enantiomers of the aminonaphthylalanines by paper chromatography (1966) (4)
Reduction of tissue norepinephrine and blood pressure by 3,5-dihydroxy-4-methoxy-phenylalanine. (1968) (4)
VI. Nomenclature and Classification of Purinoceptors * (2016) (4)
Effects of maitotoxin on atrial natriuretic factor-mediated accumulation of cyclic GMP in PC12 cells. (1990) (4)
Riboflavin: Inhibitory effects on receptors, G‐proteins, and adenylate cyclase (1997) (4)
Synthesis of tritiated functionalized congeners of 1.3-dipropylxanthine having high affinity at adenosine receptors (1986) (4)
EFFECTS OF BACTRACHOTOXIN ON ELECTROPLAX Na+‐K+‐ATPase AND LEVELS OF ATP IN RAT MUSCLE 1 (1972) (4)
Chapter 30. Cytochrome P-450 Monoxygenases and Drug Metabolism (1974) (4)
The chemorelease of norepinephrine from mouse hearts. 3. 3,5-Dihydroxy-4-methoxyphenethylamines and related compounds. (1968) (3)
Phenolic Mediators of Animal Metabolism (1967) (3)
Ernest Guenther Award in Chemistry of Natural Products. Amphibian Skin: A Remarkable Source of Biologically Active Arthropod Alkaloids (2003) (3)
The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTPγS to brain membranes (1995) (3)
Effects of ring fluorination on the adrenergic properties of phenylephrine. (1987) (3)
Maitotoxin stimulates phosphoinositide breakdown in neuroblastoma hybrid NCB-20 cells (1987) (3)
REGULATION OF CYCLIC AMP LEVELS IN BRAIN (1973) (3)
Scorpion venom (Leiurus quinquestriatus) elicits accumulations of inositol phosphates and cyclic AMP in guinea pig cortical synaptoneurosomes (1986) (3)
APEC, An A2-Selective Adenosine Agonist, is a More Potent Locomotor Depressant Than N6-Cyclohexyladenosine (1991) (3)
N 6‐Substituted 9‐methyladenines: A new class of adenosine receptor antagonists (1987) (3)
The prevention of postoperative pulmonary emboli with low-molecular-weight dextran. (1975) (2)
ALLENIC AND ACETYLENIC SPIROPIPERIDINE ALKALOIDS FROM THE NEOTROPICAL FROG. DENDROBATES HISTRIONICUS (1975) (2)
Symposium: Chemical defense in birds (1994) (2)
Progressive Necrotizing Wound Infections in Postirradiated Patients (1978) (2)
Reserpine: Interactions with Batrachotoxin and Brevetoxin Sites on Voltage-Dependent Sodium Channels (2002) (2)
cis‐ and trans‐Configurations of α,α′‐Disubstituted Piperidines and Pyrrolidines by GC‐FTIR; Application to Decahydroquinoline Stereochemistry. (1995) (2)
A new secotrinervitane diterpene isolated from soldiers of the Madagascan termite species, Nasutitermes canaliculatus. (1996) (2)
Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus) (2008) (2)
Fluorescent derivatives of strophanthidin. Interaction with sodium- and potassium-activated adenosine triphosphatase. (1972) (2)
Substrates and inhibitors of dopamine-beta-oxidase. (1962) (2)
Corrigendum to “Enantioselective syntheses of two 5, 9E diastereomers of 223V, an alkaloid from the poison frog Dendrobates pumilio” [Tetrahedron 61 (2005) 1187] (2005) (2)
Groin dissection with prevention of tissue loss and postoperative infection. (1979) (2)
Chemical and Biochemical Approaches to the Enantiomers of Chiral Fluorinated Catecholamines and Amino Acids (2000) (1)
ARENE OXIDES, A NEW ASPECT OF DRUG METABOLISM (1974) (1)
[Frog venoms. Isolation and structure of pumiliotoxin]. (1969) (1)
Effect of histrionicotoxin on ion channels in synaptic and conducting membranes of electroplax ofElectrophorus electricus (1983) (1)
Guanine Nucleotide Dependence of Calcium-Calmodulin Stimulation of Adenylate Cyclase in Rat Cerebral Cortex and Striatum (1982) (1)
A combination of benzathine penicillin G and triple sulfonamides in oral therapy of acute upper respiratory tract infections. (1954) (1)
Pyrrolizidine Oximes: A Novel New Class of Dendrobatid Alkaloids. (2010) (1)
Constitution and Analgetic Activity of a New Product in the Benzomorphan Synthesis (1965) (1)
Synthesis and Adrenergic Activities of Ring-Fluorinated Analogues of 3- (tert-Butylamino)-2-(3,4-dihydroxyphenyl)-1-propanol. (1993) (1)
Enzymatic Formation, Degradation, and Action of Cyclic Nucleotides (1977) (1)
Additions and Corrections - Purines. VI. The Preparation of Certain 6-Substituted- and 6,9-Disubstituted Purines (1956) (1)
Batrachotoxin alkaloids from passerine birds: a second toxic genus (Ifrita kowaldi) (2000) (1)
ADRENERGIC RECEPTORS AND ADENYLATE CYCLASE IN MEMBRANE PREPARATIONS FROM THE CENTRAL NERVOUS SYSTEM (1979) (1)
N6-Substituted N-Alkyladenosine-5′-uronamides: Bifunctional Ligands Having Recognition Groups for A1 and A2 Adenosine Receptors. (1987) (1)
Intramolecular migrations of aryl substituents during enzymatic hydroxylation. (1968) (1)
The Isolation and Structure of Pumiliotoxin 341A: A Novel Cyclic Ether from the Frog Epipedobates tricolor. (1999) (1)
Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the amphibia (1988) (1)
A Structure for 261C, a Novel Tricyclic Alkaloid from the Madagascan Poison Frog, Mantella betsileo. (2003) (1)
ACTIONS OF NEUROTOXINS ON THE ACETYLCHOLINE RECEPTOR–IONIC CONDUCTANCE MODULATOR UNIT AND ON SODIUM CHANNELS (1976) (1)
ENHANCED ACCUMULATIONS OF CYCLIC AMP IN BRAIN SLICES ELICITED BY NOREPINEPHRINE AFTER INTRAVENTRICULAR PRETREATMENT OF RATS WITH 6-HYDROXYDOPAMINE (1974) (1)
SYNTHESIS AND BIOLOGICAL PROPERTIES OF 2-, 5-, AND 6-FLUORONOREPINEPHRINES (1980) (1)
The Isolation and Structure of the Novel cis-Fused Indolizidine 249H from Frog Skin: cis- vs. trans-Fused Indolizidines Distinguished by NMR. (1999) (1)
Morphological appearance of yolk sac tumors of the ovary in vitro. (1977) (1)
Further studies on the interaction of loperamide with capacitative calcium entry in Leukemic HL‐60 cells (2006) (1)
Functional Role of Cyclic Nucleotides (1977) (1)
Effects of forskolin and prostaglandin E1 on leukotriene C- and D-induced plasma exudation in the rat skin. (1986) (1)
A Stereospecific Synthesis of (.+-.)-5,8-Disubstituted Indolizidines (I) and (.+-.)-1,4-Disubstituted Quinolizidines (II) and (III) Found in Poison Frog Skins. (2001) (1)
Pumiliotoxin alkaloids: Relationship of cardiotonic activity to sodium channel activity and phosphatidylinositol turnover (1988) (1)
1,3-DIALKYL-8-(P-SULFOPHENYL)XANTHINES: POTENT WATER-SOLUBLE ANTAGONISTS FOR A1- AND A2-ADENOSINE RECEPTORS (1985) (0)
Benzo(1,2-c:5,4-c′)dipyrazoles: Non-Xanthine Adenosine Antagonists. (1989) (0)
IT-substituted 9-methyladenines : a new class of adenosine receptor antagonists (2001) (0)
AR KOFFEIN BEROENDEFRAMKALLANDE ? VARLDENS MEST NYTTJADE PSYKOAKTIVA SUBSTANS PAVERKAR SAMMA DELAR AV HJARNAN SOM KOKAIN (1998) (0)
Seizures induced by methylxanthines, potential cognitive enhancers in dementia syndromes (1989) (0)
Imidazole‐induced elevations of intracellular calcium in HL‐60 cells: effect of inhibition of phospholipase C by the steroidal maleimide U73122 (2006) (0)
Synthesis and Adrenergic Activity of a Semi-Rigid Analogue of 6- Fluoronorepinephrine. (2010) (0)
Contact toxicities of anuran skin alkaloids against the fire ant (Solenopsis invicta) (2013) (0)
Exploratory Laparotomy in Recurrent Cervical Cancer (1974) (0)
Adenosine receptors. (1985) (0)
Joint committee and the prospect of white smoke on marijuana. (2015) (0)
A Naturally Occurring Erythro Diastereomer (Ic) of Pumiliotoxin B (Ia). (1989) (0)
Altered brain cyclic AMP-responses in rats reared in enriched or impoverished environments (1976) (0)
Synthesis of Pyrrolizidine Oximes 222 and 236: Novel Alkaloids of a Dendrobatid Poison Frog. (1994) (0)
Synthesis and Adrenergic Activities of Ring-Fluorinated Analogues of 2- (3,4-Dihydroxyphenyl)morpholine. (1994) (0)
Highly Stereoselective Construction of trans‐(2,3)‐cis(2,6)‐ Trisubstituted Piperidines: An Application to the Chiral Synthesis of Dendrobates Alkaloids. (1997) (0)
Alkaloids of Neotropical Poison Frogs. (Dendrobatidae). (277 Literaturzitate). (1982) (0)
Extraction and identification of Bufadienolide from toads (2003) (0)
Occurrence of carnosine in skin of certain leptodactylid frogs (1966) (0)
New adenosine receptors antagonists (1984) (0)
Accumulation of adenosine-3',5'-monophosphate (c-amp) in brain slices from the 'quaking' mouse, a neurologic mutant. Abstr. (1973) (0)
Alkaloids. Nature's Curse or Blessing By Manfred Hesse. Verlag Helvetica Chimica Acta, Zürich, Switzerland, and Wiley-VCH Weinheim, Germany. 2002. xii + 413 pp. 16 × 18 cm. $135. ISBN 3-906390-24-1. (2003) (0)
Locomotor Depression in Mice is Elicited by A1-Selective and A2-selective Adenosine Agonists (1990) (0)
Response : Pitohui : How Toxic and to Whom? (1993) (0)
Enantioselective Synthesis of Poison-Frog Alkaloid 237D (I) and Determination of Absolute Stereochemistry. (2005) (0)
Identification of Histrionicotoxins by GC-MS and GC-FTIR: Photo- and Chemical-Artefacts and Revised 13C NMR Assignments. (1992) (0)
MAMMALIAN ALKALOIDS. 8. SYNTHESIS AND BIOLOGICAL EFFECTS OF TETRAHYDROPAPAVEROLINE RELATED 1-BENZYLTETRAHYDROISOQUINOLINES (1980) (0)
Enantioselective Syntheses of Poison-Frog Alkaloids: 219F and 221I and an Epimer (I) of 193E. (2006) (0)
Living Cytology—Revisited: In Vitro Demonstration of Intraabdominal Adenocarcinomatosis (1979) (0)
7,8-DIOXOCHLORPROMAZINE, SYNTHESIS AND PROPERTIES (1975) (0)
PRELIMINARY EVALUATION OF SKIN (0)
SYNTHESIS OF PUMILIOTOXIN C (1976) (0)
Antagonism of alpha- and beta-adrenergic-mediated accumulations of cyclic AMP in rat cerebral cortical slices by the beta-antagonist (-)alprenolol. (1976) (0)
ILI-5 Potent Neurotoxin of Chiriquitoxin and Zetekitoxin from the Panamanian Golden Frogs Atelopus Species(Isolation and Structure Elucidation of Natural Products) (2006) (0)
NOREPINEPHRINE UPTAKE SITES IN CARDIAC TISSUE, LACK OF AFFINITY OF 6-HYDROXYNOREPINEPHRINE AND RELATED COMPOUNDS (1975) (0)
499 – ACTIONS OF NEUROTOXINS ON THE ACEIYLCHOLINE RECEPTOR-IONIC CONDUCTANCE MODULATOR UNIT AND ON SODIUM CHANNELS (1977) (0)
The synthesis of certain 6- and 9- substituted purines of biological interest (1955) (0)
Separation of the enantiomers of the aminonaphthyl-alanines by paper chromatography. (1966) (0)
Pseudophrynamine A: An Unusual Prenyl Pyrrolo(2,3-b)indole Ester from an Australian Frog, Pseudophryne coriacea (Myobatrachidae). (1988) (0)
SIGNIFICANCE OF THE NIH SHIFT WITH RESPECT TO LIVER MICROSOME HYDROXYLATIONS (1969) (0)
Analogues of 1,3-Dipropyl-S-phenylxanthine: Enhancement of Selectivity at A1-Adenosine Receptors by Aryl Substituents. (1987) (0)
Potential effector of Grb7 family of signaling proteins (1998) (0)
Advances in natural products chemistry, extraction, and isolation of biologically active compounds Edited by , Halsted Press, New York, 1981 (1982) (0)
Facile Synthesis of 4-Piperidones by Condensation of an α,β- Unsaturated Ketone, an Aldehyde and Ammonia: Synthesis of the Dendrobatid Frog Alkaloid 241D (XII). (1995) (0)
Chiral Synthesis of Poison‐Frog Alkaloids 251N and 221K. (2007) (0)
Convulsant properties of methylxanthines, potential cognitive enhancers in dementia syndromes (1990) (0)
ARENE OXIDES-OXEPINS (1974) (0)
STRUCTURE-ACTIVITY RELATIONSHIPS FOR ACTIVATION OF ADENYLATE CYCLASE BY THE DITERPENE FORSKOLIN AND ITS DERIVATIVES (1983) (0)
GEPHYROTOXINS, HISTRIONICOTOXINS AND PUMILIOTOXINS FROM THE NEOTROPICAL FROG DENDROBATES HISTRIONICUS (1977) (0)
Contents to volume 184 (2001) (0)
A quintuplet gestation. (1960) (0)
YUICHI KANAOKA: A Pioneer in Chemical Biology (2003) (0)
MESOIONIC XANTHINE ANALOGS: ANTAGONISTS OF ADENOSINE RECEPTORS (1985) (0)
N6,9‐Disubstituted Adenines: Effect on Affinity for Adenosine Receptors of a Chiral Center in the 9‐Substituent. (2010) (0)
Additions and Corrections - Deuterium Migration during the Acid-Catalyzed Dehydration of 6-Deutrio-5,6-dihydroxy-3-chloro-1,3-cyclohexadiene, a Nonenzymatic Model for the NIH Shift. (1968) (0)
The Enantioselective Synthesis of Poison-Frog Alkaloids (—)-203A, (—)-209B, (—)-231C, (—)-233D, (—)-235B“. (2006) (0)
Subject Index, Vol. 42, 1991 (1991) (0)
1‐Methyl‐4‐substituted‐1H‐pyrazolo(3,4‐b)pyridine‐5‐carboxylic Acid Derivatives: Effect of Structural Alterations on Activity at A1 and A2 Adenosine Receptors. (1995) (0)

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