Jeffrey Wade Harper
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Jeffrey Wade Harperbiology Degrees
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Cell Biology
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#129
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Molecular Biology
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Genetics
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Biology
Jeffrey Wade Harper's Degrees
- PhD Molecular Biology University of California, Berkeley
- Masters Biochemistry Stanford University
Why Is Jeffrey Wade Harper Influential?
(Suggest an Edit or Addition)Jeffrey Wade Harper's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases (1993) (5827)
- Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control (1995) (2185)
- WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. (1994) (2076)
- A Map of the Interactome Network of the Metazoan C. elegans (2004) (1767)
- The DNA damage response: ten years after. (2007) (1663)
- p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest (1994) (1551)
- Systematic and quantitative assessment of the ubiquitin-modified proteome. (2011) (1479)
- Defining the Human Deubiquitinating Enzyme Interaction Landscape (2009) (1448)
- Network organization of the human autophagy system (2010) (1448)
- Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex (2002) (1420)
- SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box (1996) (1419)
- F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex (1997) (1316)
- The BioPlex Network: A Systematic Exploration of the Human Interactome (2015) (1136)
- Inhibition of cyclin-dependent kinases by p21. (1995) (1063)
- Molecular definitions of autophagy and related processes (2017) (1036)
- Architecture of the human interactome defines protein communities and disease networks (2017) (1000)
- p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. (1995) (971)
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy (2014) (923)
- The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase (2004) (871)
- The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro (1999) (861)
- The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation (2004) (851)
- Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle (1992) (847)
- Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization (2013) (831)
- Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways (2015) (816)
- Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCFFbw7 Ubiquitin Ligase (2001) (803)
- Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. (1999) (786)
- Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome (1997) (784)
- Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways (2009) (772)
- Systematic analysis and nomenclature of mammalian F-box proteins. (2004) (651)
- Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide (2014) (618)
- Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex (2000) (598)
- A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (2006) (592)
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. (2015) (592)
- Drug discovery in the ubiquitin–proteasome system (2006) (567)
- The anaphase-promoting complex: it's not just for mitosis any more. (2002) (535)
- Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. (2014) (522)
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway (2016) (506)
- Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. (1996) (502)
- BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3 (2003) (500)
- Structure of a -TrCP1-Skp1--Catenin Complex (2003) (497)
- Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair (2009) (464)
- Deletion of p16 and p15 genes in brain tumors. (1994) (464)
- How the Cyclin Became a Cyclin Regulated Proteolysis in the Cell Cycle (1999) (463)
- A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation (2006) (460)
- Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. (1994) (445)
- Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. (2007) (444)
- The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3 (2011) (431)
- Cdk inhibitors in development and cancer. (1996) (427)
- Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (1997) (425)
- Defining human ERAD networks through an integrative mapping strategy (2011) (419)
- The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. (2005) (417)
- Anticancer drug targets: cell cycle and checkpoint control. (1999) (409)
- p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. (1999) (408)
- Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. (1999) (406)
- Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. (2000) (398)
- The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. (1999) (397)
- Cancer Proliferation Gene Discovery Through Functional Genomics (2008) (396)
- Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). (2005) (394)
- Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. (2003) (388)
- SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (1999) (385)
- Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. (2009) (384)
- A family of mammalian F-box proteins (1999) (378)
- Cdk inhibitors: on the threshold of checkpoints and development. (1994) (373)
- Building and decoding ubiquitin chains for mitophagy (2018) (371)
- SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. (2003) (370)
- Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities (2007) (365)
- Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging (2007) (361)
- Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. (1992) (359)
- Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. (2000) (349)
- A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. (2010) (344)
- Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics (2010) (338)
- Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. (1998) (331)
- SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway (2017) (324)
- Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. (1996) (312)
- Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex (2006) (308)
- SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation (2008) (307)
- Dual proteome-scale networks reveal cell-specific remodeling of the human interactome (2020) (289)
- Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P (2016) (282)
- Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. (2004) (268)
- Building and remodelling Cullin–RING E3 ubiquitin ligases (2013) (268)
- CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. (1993) (267)
- In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. (1995) (266)
- SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Proteinm* (2005) (263)
- Purification of heparin-binding growth factors. (1986) (261)
- Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress (2015) (257)
- Insulin‐like growth factor ligands, receptors, and binding proteins in cancer (2005) (252)
- Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis (2015) (247)
- N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex (2011) (245)
- Extensive Gene Traffic on the Mammalian X Chromosome (240)
- Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy (2015) (237)
- Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence (2019) (236)
- mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. (2011) (230)
- Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor. (1985) (225)
- Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. (2006) (220)
- Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. (2008) (220)
- The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (2010) (218)
- Constructing and decoding unconventional ubiquitin chains (2011) (212)
- Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization (2016) (211)
- Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition (2003) (206)
- CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. (1992) (205)
- Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation (2016) (203)
- A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling (2011) (203)
- Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. (2002) (202)
- Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism (2017) (194)
- Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. (2010) (193)
- Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes (1999) (193)
- Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses (2012) (192)
- SCF-mediated protein degradation and cell cycle control (2005) (186)
- The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. (2009) (185)
- Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity (2012) (177)
- Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. (1985) (173)
- Coupling of DNA Synthesis and Histone Synthesis in S Phase Independent of Cyclin/cdk2 Activity (2002) (171)
- Proteome complexity and the forces that drive proteome imbalance (2016) (169)
- Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. (2019) (168)
- DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. (2011) (166)
- The role of Cdk7 in CAK function, a retro-retrospective. (1998) (165)
- Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. (1993) (158)
- Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers (2012) (157)
- Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8 (2014) (153)
- Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation (2016) (152)
- TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. (2019) (151)
- Uba1 functions in Atg7- and Atg3-independent autophagy (2013) (150)
- Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication. (1999) (149)
- Identification and Functional Evaluation of Cellular and Viral Factors Involved in the Alteration of Nuclear Architecture during Herpes Simplex Virus 1 Infection (2005) (148)
- Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes. (2016) (141)
- Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E (1999) (139)
- Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase* (2004) (138)
- Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. (2019) (133)
- Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling (2012) (130)
- QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology (2015) (129)
- System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. (2016) (126)
- The tumor suppressor CYLD regulates entry into mitosis (2007) (126)
- Structural Complexity in Ubiquitin Recognition (2006) (125)
- G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts (1998) (124)
- Quantifying ubiquitin signaling. (2015) (124)
- Cyclin C is a haploinsufficient tumour suppressor (2014) (124)
- A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. (1996) (123)
- Ubiquitin proteasome system (UPS): what can chromatin do for you? (2007) (122)
- GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution. (2010) (121)
- Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. (2018) (120)
- A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. (2015) (118)
- The Cyclin E/Cdk2 Substrate p220NPAT Is Required for S-Phase Entry, Histone Gene Expression, and Cajal Body Maintenance in Human Somatic Cells (2003) (115)
- S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation (1997) (114)
- A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. (2011) (113)
- Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C (2016) (113)
- Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. (1996) (113)
- Systematic Analysis of Ribophagy in Human Cells Reveals By-stander Flux During Selective Autophagy (2017) (113)
- TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling (2017) (112)
- Cyclin-dependent kinases. (2001) (110)
- Protein destruction: Adapting roles for Cks proteins (2001) (108)
- A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. (2001) (107)
- The F-box Protein FBX4 Targets PIN2/TRF1 for Ubiquitin-mediated Degradation and Regulates Telomere Maintenance* (2006) (107)
- Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability. (2017) (103)
- The histone demethylase LSD1/KDM1A promotes the DNA damage response (2013) (102)
- A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. (2010) (102)
- Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate (2016) (100)
- TIRR regulates 53BP1 by masking its histone methyl-lysine binding function (2017) (100)
- Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling (2020) (100)
- A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling (2007) (100)
- The Oncoprotein Kinase Chaperone CDC37 Functions as an Oncogene in Mice and Collaborates with Both c-mycand Cyclin D1 in Transformation of Multiple Tissues (2000) (99)
- An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (2008) (97)
- HiNF-P Directly Links the Cyclin E/CDK2/p220NPAT Pathway to Histone H4 Gene Regulation at the G1/S Phase Cell Cycle Transition (2005) (95)
- Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (2013) (94)
- Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression (2010) (94)
- Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates. (1984) (94)
- G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells (2017) (93)
- Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. (2010) (92)
- Cyclin/CDK Regulates the Nucleocytoplasmic Localization of the Human Papillomavirus E1 DNA Helicase (2004) (92)
- An Oriented Peptide Array Library (OPAL) Strategy to Study Protein-Protein Interactions* (2004) (92)
- Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (2013) (91)
- RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway (2018) (90)
- The X-Linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain (2013) (90)
- Exit from Exit Resetting the Cell Cycle through Amn1 Inhibition of G Protein Signaling (2003) (90)
- An OBSL1-Cul7Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning (2011) (90)
- The ORFeome Collaboration: a genome-scale human ORF-clone resource (2016) (89)
- Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response (2014) (88)
- The role of protein stability in the cell cycle and cancer. (1998) (87)
- A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation (2019) (87)
- SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation (2011) (86)
- Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes (2012) (85)
- Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux (2017) (83)
- Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells (2008) (82)
- Reversal of Growth Suppression by p107 via Direct Phosphorylation by Cyclin D1/Cyclin-Dependent Kinase 4 (2002) (80)
- Cyclin F Disruption Compromises Placental Development and Affects Normal Cell Cycle Execution (2004) (80)
- Expression of Met-(-1) angiogenin in Escherichia coli: conversion to the authentic less than Glu-1 protein. (1988) (80)
- The Tumor-specific Hyperactive Forms of Cyclin E Are Resistant to Inhibition by p21 and p27* (2005) (79)
- Culprits in the degradation of cyclin E apprehended. (1999) (79)
- TIMMDC1/C3orf1 Functions as a Membrane-Embedded Mitochondrial Complex I Assembly Factor through Association with the MCIA Complex (2013) (78)
- Understanding Cullin-RING E3 Biology through Proteomics-based Substrate Identification* (2012) (77)
- The Cyclin E/Cdk2 Substrate and Cajal Body Component p220NPAT Activates Histone Transcription through a Novel LisH-Like Domain (2003) (76)
- Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors. (1985) (75)
- The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase (2020) (73)
- Selective isotopic enrichment of synthetic RNA: application to the HIV-1 TAR element. (1993) (72)
- Structure of a -TrCP1-Skp1--Catenin Complex: Destruction Motif Binding and Lysine Specificity (2003) (68)
- Identification of HiNF-P, a Key Activator of Cell Cycle-Controlled Histone H4 Genes at the Onset of S Phase (2003) (66)
- Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates. (1987) (66)
- Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase (2017) (64)
- Regulation of Postsynaptic RapGAP SPAR by Polo-like Kinase 2 and the SCFβ-TRCP Ubiquitin Ligase in Hippocampal Neurons*S⃞ (2008) (63)
- A phosphorylation-driven ubiquitination switch for cell-cycle control. (2002) (61)
- Differential Roles for Checkpoint Kinases in DNA Damage-dependent Degradation of the Cdc25A Protein Phosphatase* (2008) (61)
- Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220NPAT in human embryonic stem cells (2007) (60)
- Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins. (2011) (59)
- Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation (2016) (59)
- A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex (2013) (58)
- Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells (2019) (57)
- HeLa Cells Are Phenotypically Limiting in Cyclin E/CDK2 for Efficient Human Papillomavirus DNA Replication* (2000) (56)
- Amino acid sequence of bovine brain derived class 1 heparin-binding growth factor. (1986) (56)
- DNA damage: ubiquitin marks the spot (2008) (55)
- Interwoven Ubiquitination Oscillators and Control of Cell Cycle Transitions (2004) (55)
- SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Caenorhabditis elegans Germline (2012) (55)
- Cullin-RING Ubiquitin Ligase Regulatory Circuits: a Quarter Century Beyond the F-box Hypothesis. (2021) (54)
- Brd4 Regulation of Papillomavirus Protein E2 Stability (2009) (51)
- Two potentially oncogenic cyclins, cyclin A and cyclin D1, share common properties of subunit configuration, tyrosine phosphorylation and physical association with the Rb protein. (1993) (50)
- Visualization of a highly organized intranuclear network of filaments in living mammalian cells. (2004) (49)
- Skipping into the E2F1-destruction pathway (1999) (49)
- The SCF–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkBa and b-catenin and stimulates IkBa ubiquitination in vitro (1999) (49)
- Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. (2002) (49)
- Ribosome Abundance Control Via the Ubiquitin-Proteasome System and Autophagy. (2020) (49)
- Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP (2016) (48)
- The cellular chamber of doom. (2001) (48)
- Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C (2018) (48)
- Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis (2015) (46)
- Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis. (1999) (45)
- BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data. (2018) (45)
- Neddylating the Guardian Mdm2 Catalyzed Conjugation of Nedd8 to p53 (2004) (44)
- Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. (2013) (42)
- NCoR1 Mediates Papillomavirus E8^E2C Transcriptional Repression (2010) (41)
- CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15 (1993) (40)
- Systematic Quantitative Analysis of Ribosome Inventory Upon Nutrient Stress (2020) (40)
- Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy (2019) (39)
- QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease (2016) (39)
- Negative regulation of SCFSkp2 ubiquitin ligase by TGF-β signaling (2004) (37)
- Proteomic Analysis and Identification of Cellular Interactors of the Giant Ubiquitin Ligase HERC2 (2014) (36)
- Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function (2019) (35)
- Emerging Anatomy of the BAP1 Tumor Suppressor System (2012) (35)
- The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells (2019) (34)
- Reaction of peptide thiobenzyl esters with mammalian chymotrypsinlike enzymes: a sensitive assay method. (1981) (34)
- A covalent angiogenin/ribonuclease hybrid with a fourth disulfide bond generated by regional mutagenesis. (1989) (34)
- Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0 (2014) (34)
- NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms (2019) (33)
- Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells. (2007) (33)
- The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis (2016) (31)
- TIF1γ Protein Regulates Epithelial-Mesenchymal Transition by Operating as a Small Ubiquitin-like Modifier (SUMO) E3 Ligase for the Transcriptional Regulator SnoN1* (2014) (31)
- ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. (2019) (30)
- A Tribute to Arthur Kornberg 1918–2007 (2008) (30)
- Angelman syndrome–associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome (2018) (29)
- Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin. (1988) (28)
- Cyclin‐Dependent Kinases (2001) (27)
- p21 and p57 control muscle differentiation at the myogenin step (1999) (27)
- Bortezomib-Mediated Inhibition of Steroid Receptor Coactivator-3 Degradation Leads to Activated Akt (2008) (27)
- Isotope labeling for 13C relaxation measurements on RNA. (1995) (27)
- 3-Alkoxy-7-amino-4-chloroisocoumarins: a new class of suicide substrates for serine proteases (1984) (27)
- Expression and purification of recombinant rat protein disulfide isomerase from Escherichia coli. (1991) (26)
- Conserved residues flanking the thiol/disulfide centers of protein disulfide isomerase are not essential for catalysis of thiol/disulfide exchange. (1992) (25)
- Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. (2004) (25)
- Purification and assay of the budding yeast anaphase-promoting complex. (2005) (24)
- Elevated Skp 2 Protein Expression in Human Prostate Cancer : Association with Loss of the Cyclin-dependent Kinase Inhibitor p 27 and PTEN and with Reduced Recurrence-free Survival 1 (2002) (24)
- Uba 1 functions in Atg 7-and Atg 3-independent autophagy (2013) (24)
- Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons (2019) (24)
- Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor. (1986) (23)
- A license to kill: transcriptional activation and enhanced turnover of Myc by the SCF(kp2) ubiquitin ligase. (2003) (23)
- Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy (2021) (23)
- Mutagenesis of residues flanking Lys-40 enhances the enzymatic activity and reduces the angiogenic potency of angiogenin. (1990) (22)
- Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration (2020) (22)
- Erratum: The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation (Proceedings of the National Academy of Science of the United States of America (June 15, 2004) 101, 24 (9085-9090) DOI: 10.1073/pnas.0402770101) (2006) (21)
- Enzymatically active angiogenin/ribonuclease A hybrids formed by peptide interchange. (1988) (19)
- Correction: Corrigendum: Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis (2016) (18)
- New mechanism-based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthalide (1983) (18)
- Purification and analysis of CIP/KIP proteins. (1997) (18)
- Inhibitors for E3 ubiquitin ligases (2010) (18)
- A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin (2016) (18)
- A Novel Hap1–Tsc1 Interaction Regulates Neuronal mTORC1 Signaling and Morphogenesis in the Brain (2013) (17)
- CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF‐P (2009) (17)
- Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A alpha, and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones. (1985) (16)
- DNA-Damage Control: Claspin Destruction Turns off the Checkpoint (2006) (16)
- CDK 2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC 2 in the cell cycle ( cell cycle regulation / cyclins / threonine-serine protein kinase / phosphotyrosine ) (16)
- ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection (2021) (16)
- Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death* (2017) (16)
- CANCER-RELEVANT CULLIN-RING UBIQUITIN LIGASES (2005) (15)
- Analysis of mammalian Cdc37, a protein kinase targeting subunit of heat shock protein 90. (1997) (14)
- iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation (2021) (13)
- Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity. (1988) (12)
- HiNF‐P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription (2007) (12)
- The CASTOR Proteins Are Arginine Sensors for the mTORC 1 Pathway Graphical (2016) (11)
- Refolded HIV-1 tat protein protects both bulge and loop nucleotides in TAR RNA from ribonucleolytic cleavage. (1991) (11)
- Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes (2019) (10)
- Selective 5' modification of T7 RNA polymerase transcripts. (1992) (9)
- The histone demethylase LSD 1 / KDM 1 A promotes the DNA damage response (2013) (9)
- Stuck in the Middle: Drugging the Ubiquitin System at the E2 Step (2011) (8)
- Chemical biology: A degrading solution to pollution (2007) (8)
- From loops to chains: unraveling the mysteries of polyubiquitin chain specificity and processivity. (2006) (7)
- RING finger specificity in SCF-driven protein destruction. (2002) (7)
- Cdc25A and Dub3 in a high-stakes balancing act (2010) (7)
- proteins Systematic analysis and nomenclature of mammalian F-box data (2004) (6)
- Mapping cell structure across scales by fusing protein images and interactions (2020) (6)
- Cell biology: Balancing act (2014) (6)
- Telomeric TuRF1 wars. (2010) (5)
- Observation of a chloride-dependent intermediate during catalysis by angiotensin converting enzyme using radiationless energy transfer. (1987) (5)
- Efp: A ring of independence? (2002) (5)
- NCoR 1 Mediates Papillomavirus E 8 E 2 C Transcriptional Repression † (2010) (5)
- The catalytic mechanism of angiotensin converting enzyme and related zinc enzymes. (1986) (5)
- Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical (3)
- Ubiquitin Gets CARDed (2010) (3)
- A road map of cellular protein homeostasis. (2009) (3)
- How the Cyclin Became a Minireview Cyclin: Regulated Proteolysis in the Cell Cycle (1999) (3)
- TeraFly: real-time three-dimensional visualization and annotation of terabytes of multidimensional volumetric images (2017) (3)
- Conformational characterization of human angiogenin by limited proteolysis (1988) (3)
- The F-box Protein FBX4 Targets PIN2/TRF1 for Ubiquitin- mediated Degradation and Regulates Telomere (2006) (3)
- Spindle assembly factor protection. (2014) (2)
- Deafening cycle (2003) (2)
- Cell biology: Stairway to the proteasome (2009) (2)
- Protein aggregates caught stalling (2018) (2)
- Abstract 18: Prohibitin 1 regulates apoptosis via its interaction with XIAP (2015) (2)
- Live imaging defines the dynamics and molecular basis of in vivo mitophagy (2020) (2)
- The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.) (2019) (1)
- Live imaging of reporter zebrafish reveals dynamics and molecular basis of physiological-stress induced mitophagy (2020) (1)
- Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1 (2021) (1)
- Abstract 4272: Mutations inRABL3alter RAS prenylation and are associated with hereditary pancreatic cancer (2017) (1)
- Author response: EDF1 coordinates cellular responses to ribosome collisions (2020) (1)
- Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy (2020) (1)
- Resource Defining the Human Deubiquitinating Enzyme Interaction Landscape (1)
- of Cyclin D1 by the SCF FBX4-aB Crystallin Complex (2006) (1)
- Proteomics-based Cullin-RING E3 substrate identification (2012) (1)
- Super Heavy TMTpro Labeling Reagent: An Alternative and Higher-Charge-State-Amenable Stable-Isotope-Labeled TMTpro Variant. (2021) (1)
- proteinsanalysis and nomenclature of mammalian F-box (2006) (0)
- Methods Preparation of Proteins and Antibodies Puri®cation of Pid from Nuclear Extracts P53 Deacetylation Assay (0)
- network identifies SIRT 3-ATP synthase association d SIRT 3 binds ATP 5 O in a stress-and pH-sensitive manner d SIRT 3 links fuel utilization with membrane potential homeostasis (2016) (0)
- Cdk2: cyclin-dependent kinase 2 (vertebrates) (1995) (0)
- Identification of Genes Regulated by Proteolysis (2005) (0)
- Resource System-Wide Modulation o f HECT E 3 Ligases with Selective Ubiquitin Variant Probes Graphical Abstract Highlights (2016) (0)
- Host ubiquitin protein tags lipid to fight bacteria (2021) (0)
- Human mutant angiogenin (angiogenesis factor with superior angiogenin activity) genes for it and method of expression. (1989) (0)
- Association of the HPV-16 E7 oncoprotein with the cullin 2 ubiquitin ligase complex. (2006) (0)
- Proteines et genes a sequence f (1998) (0)
- itor of Cdk 2 and Cdk 4 kinase complexes in vitro ( Gu (0)
- Faculty Opinions recommendation of E3 ubiquitin ligase that recognizes sugar chains. (2002) (0)
- Protein aggregates caught stalling. (2018) (0)
- Structure of the Skp1-Fbw7 complex (2007) (0)
- Cyclin dependent kinase inhibitors. (1997) (0)
- Identification of Pathways Required for the Coordination of Late Mitotic Events in Animal Cells (2004) (0)
- Simply quantifying ubiquitin complexity (2011) (0)
- Developmental Cell Previews Telomeric TuRF 1 Wars (2011) (0)
- Deletion ofpl 6 and pl 5 Genes in Brain Tumors 1 (2006) (0)
- APC10/DOC1 SUBUNIT OF S. cerevisiae (2002) (0)
- Structure of the Skp1-Fbw7-CyclinEdegC complex (2007) (0)
- TITLE : Role of cdc 37 in Breast Cancer (0)
- Dynamics of PARKIN-Depe ndent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics Graphical (0)
- Advances in Brief WAF 1 / CIP 1 Is Induced in / ? 53-mediated G ! Arrest and Apoptosis 1 (2006) (0)
- Functional Genomics Cancer Proliferation Gene Discovery Through (2010) (0)
- Abstract 4986: Pancreatic cancers develop metabolic resistance pathways to glutaminase inhibition (2017) (0)
- DCNL complex with N-terminally acetylated NEDD8 E2 peptide (2012) (0)
- The Role of Cyclin Dependent Kinase Inhibitor, CIP1, in Breast Cancer. (1995) (0)
- Regulation of NF (kappa) B-Dependent Cell Survival Signals Through the SCF (Slimb) Ubiquitin Ligase Pathway (2002) (0)
- Human ATG 8 Modifiers Autophagy Pathways by Direct Binding to Autophagy : Regulation of Endocytic and Rab GTPase-Activating Proteins in (2012) (0)
- Molecular Dissection of the 8 Phase Transcriptional Program Controlled by Cyclin E-P220 NPAT Signaling Pathway (2005) (0)
- Number : DAMD 17-011-0135 TITLE : Identification of Genes Regulated by Proteolysis (0)
- Silva , by Multiplex RNAi Screening Profiling Essential Genes in Human Mammary Cells (2009) (0)
- NCoR1 Mediates Papillomavirus E8 (cid:1) E2C Transcriptional Repression (cid:1) † (2010) (0)
- Retinoblastoma Protein in Growth Control and Differentiation (2001) (0)
- 'Ubiquitylation: mechanism and functions' review series (2013) (0)
- yeast Cul1WHB-Dcn1P acetylated Ubc12N complex (2011) (0)
- N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-stapled acetylated Ubc12N complex (2011) (0)
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What Schools Are Affiliated With Jeffrey Wade Harper?
Jeffrey Wade Harper is affiliated with the following schools:
