John Wahren
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John Wahren's Degrees
- PhD Biochemistry University of California, Berkeley
- Doctorate Medicine Stanford University
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(Suggest an Edit or Addition)John Wahren's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization (1981) (1750)
- Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. (1985) (1124)
- Liver and kidney metabolism during prolonged starvation. (1969) (780)
- Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. (1974) (770)
- Amino acid metabolism during prolonged starvation. (1969) (659)
- Glucose metabolism during leg exercise in man. (1971) (611)
- Insulin resistance in uremia. (1981) (600)
- Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. (1998) (498)
- Contributions of gluconeogenesis to glucose production in the fasted state. (1996) (473)
- Amino acid metabolism in exercising man. (1971) (421)
- Synergistic interaction between exercise and insulin on peripheral glucose uptake. (1981) (408)
- Fuel homeostasis in exercise. (1975) (391)
- Leg blood flow during exercise in man. (1971) (388)
- Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. (1976) (373)
- Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. (1994) (356)
- Substance P: a pioneer amongst neuropeptides (2001) (344)
- Specific binding of proinsulin C-peptide to human cell membranes. (1999) (339)
- Increased 24-hour energy expenditure in cigarette smokers. (1986) (321)
- Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. (1972) (321)
- Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. (1978) (317)
- Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. (1971) (308)
- Role of C-peptide in human physiology. (2000) (275)
- Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. (1999) (260)
- Beneficial effects of C‐peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus (2000) (259)
- Influence of Oral Glucose Ingestion on Splanchnic Glucose and Gluconeogenic Substrate Metabolism in Man (1975) (258)
- Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. (1995) (250)
- INFLUENCE OF SOMATOSTATIN ON CARBOHYDRATE DISPOSAL AND ABSORPTION IN DIABETES MELLITUS (1976) (239)
- Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. (1975) (232)
- Effect of in vivo contact between blood and dialysis membranes on protein catabolism in humans. (1990) (231)
- Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. (2005) (217)
- Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. (1983) (214)
- Splanchnic glucose and amino acid metabolism in obesity. (1974) (213)
- Thermic effect of glucose in man. Obligatory and facultative thermogenesis. (1984) (206)
- Evidence of inter-organ amino-acid transport by blood cells in humans. (1973) (202)
- THE EFFECT OF LOCAL ANAESTHETICS ON THE CENTRAL CIRCULATION AND RESPIRATION IN MAN AND DOG1),2) (1968) (202)
- Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state. (1995) (195)
- Leg glucose uptake during maximal dynamic exercise in humans. (1986) (188)
- Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. (1980) (181)
- Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetes. (2003) (179)
- Splanchnic regulation of glucose production. (2007) (174)
- Hypoglycemia during prolonged exercise in normal men. (1982) (174)
- Influence of beta-adrenergic blockade on glucose-induced thermogenesis in man. (1983) (169)
- Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. (1993) (169)
- Increased Peripheral Insulin Sensitivity and Muscle Mitochondrial Enzymes but Unchanged Blood Glucose Control in Type I Diabetics After Physical Training (1982) (167)
- C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat (2001) (164)
- The influence of human C-peptide on renal function and glucose utilization in Type 1 (insulin-dependent) diabetic patients (1992) (160)
- Uptake of individual free fatty acids by skeletal muscle and liver in man. (1972) (160)
- Is Intravenous Administration of Branched Chain Amino Acids Effective in the Treatment of Hepatic Encephalopathy? A Multicenter Study (2007) (155)
- C-peptide is a bioactive peptide (2007) (155)
- Splanchnic and muscle metabolism during exercise in NIDDM patients. (1995) (151)
- Influence of age on the local circulatory adaptation to leg exercise. (1974) (147)
- Muscle metabolism in patients with chronic obstructive lung disease and acute respiratory failure. (1977) (146)
- Noninvasive tracing of Krebs cycle metabolism in liver. (1991) (144)
- Normalization of ventilation/perfusion relationships after liver transplantation in patients with decompensated cirrhosis: Evidence for a hepatopulmonary syndrome (1990) (141)
- Influence of Maturity-onset Diabetes on Splanchnic Glucose Balance After Oral Glucose Ingestion (1978) (139)
- Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans. (1977) (134)
- The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes (2012) (134)
- Human forearm muscle metabolism during exercise. II. Uptake, release and oxidation of individual FFA and glycerol. (1968) (134)
- Ammonia metabolism during exercise in man. (1985) (132)
- C-peptide exerts beneficial effects on myocardial blood flow and function in patients with type 1 diabetes. (2002) (132)
- C-peptide stimulates rat renal tubular Na+, K+-ATPase activity in synergism with neuropeptide Y (1996) (131)
- Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man. (1976) (129)
- Quantitative aspects of blood flow and oxygen uptake in the human forearm during rhythmic exercise. (1966) (128)
- Circulatory responses to arm exercise with different arm positions. (1968) (123)
- Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. (1984) (120)
- Muscle ammonia and amino acid metabolism during dynamic exercise in man. (1986) (119)
- Quantifying gluconeogenesis during fasting. (1997) (117)
- Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid Published, JLR Papers in Press, January 24, 2007. (2007) (116)
- The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man. (1980) (114)
- Branched-chain amino acids in the treatment of chronic hepatic encephalopathy. (1982) (112)
- Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na+,K+-ATPase activity in diabetes mellitus type I. (2000) (112)
- Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. (1977) (111)
- Differential effects of proinsulin C-peptide fragments on Na +, K +-ATPase activity of renal tubule segments (1998) (110)
- Splanchnic glucose and muscle glycogen metabolism after glucose feeding during postexercise recovery. (1978) (109)
- Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. (1980) (109)
- Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia. (1981) (105)
- Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of Type 1 (insulin-dependent) diabetic patients (1992) (105)
- The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. (2005) (104)
- C-peptide improves autonomic nerve function in IDDM patients (1996) (104)
- Substrate utilization by the inactive leg during one-leg or arm exercise. (1975) (102)
- Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. (1988) (102)
- Effects of proinsulin C-peptide in experimental diabetic neuropathy: vascular actions and modulation by nitric oxide synthase inhibition. (2003) (102)
- Influence of glucose and fructose ingestion on the capacity for long-term exercise in well-trained men. (1984) (96)
- Glutamine and Glutamate Metabolism in Normal and Diabetic Subjects (1973) (96)
- Muscle metabolism during exercise in hemiparetic patients. (1977) (96)
- Amino acid and protein metabolism in diabetes mellitus. (1977) (95)
- Cerebral effects of nicotine during cognition in smokers and non-smokers (1998) (95)
- C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. (2005) (95)
- Plasma glucagon levels in exercising man. (1972) (94)
- Augmented thermic effect of amino acids under general anaesthesia: a mechanism useful for prevention of anaesthesia-induced hypothermia. (1994) (90)
- Smokeless tobacco use and atherosclerosis: an ultrasonographic investigation of carotid intima media thickness in healthy middle-aged men. (1997) (88)
- Insulin, glucagon, and somatostatin in normal physiology and diabetes mellitus. (1976) (87)
- Site of nicotine absorption from a vapour inhaler – comparison with cigarette smoking (2000) (86)
- Haemodynamic effects of a long-acting somatostatin analogue in patients with liver cirrhosis. (1987) (86)
- Free fatty acid metabolism of the human heart at rest. (1969) (84)
- Quantitation of the pathways of hepatic glycogen formation on ingesting a glucose load. (1987) (83)
- Effect of nicotinic acid on physical working capacity and on metabolism of muscle glycogen in man. (1969) (83)
- Glycerol production and utilization in humans: sites and quantitation. (1996) (81)
- Splanchnic and peripheral glucose and lactate metabolism during and after prolonged arm exercise. (1986) (81)
- C-peptide stimulates Na+, K+-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells (2004) (80)
- Direct measurements of the permeability surface area for insulin and glucose in human skeletal muscle. (2003) (80)
- Glucose and amino acid metabolism during recovery after exercise. (1973) (80)
- C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells (2004) (79)
- Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. (1991) (79)
- Physiological effects and therapeutic potential of proinsulin C-peptide. (2014) (76)
- C-peptide: new findings and therapeutic possibilities. (2015) (73)
- Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects (2006) (72)
- Insulin-mediated potassium uptake is normal in uremic and healthy subjects. (1984) (72)
- A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man. (1981) (71)
- Glucose Turnover During Exercise in Healthy Man and in Patients with Diabetes Mellitus (1979) (71)
- GLUCOSE TURNOVER DURING EXERCISE IN MAN * (1977) (71)
- Molecular effects of proinsulin C-peptide. (2002) (70)
- Human forearm muscle metabolism during exercise. V. Quantitative aspects of glucose uptake and lactate production during prolonged exercise. (1970) (70)
- The Lilly Lecture 1976: Insulin, Glucagon, and Somatostatin in Normal Physiology and Diabetes Mellitus (1976) (69)
- Effect of indomethacin on basal and carbon dioxide stimulated cerebral blood flow in man (1981) (68)
- THE EFFECT OF LOCAL ANAESTHETICS ON THE CENTRAL CIRCULATION AND RESPIRATION IN MAN NAD DOG (1971) (68)
- C-peptide binding to human cell membranes: importance of Glu27. (2001) (67)
- Determination of leg blood flow during exercise in man: an indicator-dilution technique based on femoral venous dye infusion. (1973) (66)
- The influence of a long-acting somatostatin analogue on splanchnic haemodynamics and metabolism in healthy subjects and patients with liver cirrhosis. (1986) (65)
- Protein turnover and amino acid metabolism in the regulation of gluconeogenesis. (1974) (65)
- Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. (2010) (65)
- C‐peptide: new findings and therapeutic implications in diabetes (2004) (64)
- Proinsulin C-peptide and its analogues induce intracellular Ca2+ increases in human renal tubular cells (2002) (64)
- Influence of lactate infusion on glucose and FFA metabolism in man. (1976) (64)
- Metabolism of Free Fatty Acids and Ketone Bodies in Skeletal Muscle (1971) (63)
- Physical exercise and fuel homeostasis in diabetes mellitus (1978) (63)
- Cellular internalization of proinsulin C-peptide (2007) (62)
- Physiological variation of blood lymphocyte reactivity: T-cell subsets, immunoglobulin production, and mixed-lymphocyte reactivity. (1983) (62)
- Uptake of Individual Amino Acids by the Human Brain 1 (1973) (61)
- Influence of Physical Training on Formation of Muscle Capillaries in Type I Diabetes (1984) (61)
- Leg blood flow and muscle metabolism in occlusive arterial disease of the leg before and after reconstructive surgery. (1975) (61)
- Ventilation-perfusion inequality in patients with non-alcoholic liver cirrhosis. (1991) (61)
- Onset of Angina Pectoris in Relation to Circulatory Adaptation during Arm and Leg Exercise (1971) (60)
- Hormonal interactions in the regulation of blood glucose. (1979) (60)
- Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial (2016) (59)
- Long‐term use of smokeless tobacco and physical performance in middle‐aged men (1997) (59)
- Human Forearm Muscle Metabolism during Exercise III Uptake, release and oxidation of β-hydroxybutyrate and observations on the β-hydroxybutyrate/acetoacetate ratio (1968) (59)
- C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes (2006) (58)
- Rat C peptide I and II stimulate glucose utilization in STZ-induced diabetic rats (1999) (57)
- Role of Insulin and Glucagon in the Regulation of Hepatic Glucose Production During Exercise (1979) (56)
- C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes patients. (2004) (56)
- Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia. (1988) (55)
- The Contrasting Responses of Splanchnic and Renal Glucose Output to Gluconeogenic Substrates and to Hypoglucagonemia in 60-h-fasted Humans (1980) (55)
- Splanchnic and leg exchange of free fatty acids in patients with liver cirrhosis. (1986) (54)
- Influence of hyperthyroidism on splanchnic exchange of glucose and gluconeogenic precursors. (1981) (53)
- Long-term physical training in female Type 1 (insulin-dependent) diabetic patients: absence of significant effect on glycaemic control and lipoprotein levels (2006) (53)
- Quantification of the pathways followed in hepatic glycogen formation from glucose (1988) (52)
- Brain substrate utilisation during acute hypoglycaemia (1999) (52)
- Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. (1994) (52)
- Quantifying gluconeogenesis during fasting. (1997) (51)
- Pentose pathway in human liver. (1988) (51)
- Human forearm muscle metabolism during exercise. VI. Substrate utilization in prolonged fasting. (1971) (50)
- Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man. (1994) (50)
- Influence of somatostatin on splanchnic haemodynamics in patients with liver cirrhosis. (1984) (50)
- C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanism. (2003) (49)
- New Tricks by an Old Dog (2008) (49)
- Effects of Pancreas Transplantation on Metabolic and Hormonal Profiles in IDDM Patients (1989) (48)
- Simulation and evaluation of nicotine intake during passive smoking: Cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine (1990) (48)
- Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls. (1989) (47)
- C‐peptide and long‐term complications of diabetes (2011) (47)
- Heat leakage across the abdominal wall and meal-induced thermogenesis in normal-weight and obese subjects. (1992) (47)
- Glucose production and gluconeogenesis in adults with uncomplicated falciparum malaria. (1997) (46)
- A limitation in the use of mass isotopomer distributions to measure gluconeogenesis in fasting humans. (1995) (46)
- New aspects on biological activity of C-peptide in IDDM patients. (2009) (46)
- Turnover and splanchnic metabolism of free fatty acids in hyperthyroid patients. (1981) (45)
- Molecular and Cellular Effects of C-peptide—New Perspectives on an Old Peptide (2004) (45)
- C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats. (2004) (45)
- C‐peptide improves neuropathy in type 1 diabetic BB/Wor‐rats (2007) (44)
- VASODILATING ACTION OF SUBSTANCE P IN THE HUMAN FOREARM. (1965) (44)
- C‐peptide revisited – new physiological effects and therapeutic implications (1996) (43)
- Whole body and splanchnic oxygen consumption and blood flow after oral ingestion of fructose or glucose. (1993) (42)
- N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans. (1989) (42)
- Specific binding of proinsulin C-peptide to intact and to detergent-solubilized human skin fibroblasts. (2001) (42)
- Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism. (2007) (42)
- Circulation in the calf at rest, after arterial occlusion and after exercise in normal subjects and in patients with intermittent claudication. (2009) (41)
- THE EFFECT OF MEPIVACAINE AND LIDOCAINE ON FOREARM RESISTANCE AND CAPACITANCE VESSELS IN MAN (1970) (41)
- Limitations in estimating gluconeogenesis and Cori cycling from mass isotopomer distributions using [U-13C6]glucose. (1998) (41)
- 14C-labeled propionate metabolism in vivo and estimates of hepatic gluconeogenesis relative to Krebs cycle flux. (1993) (41)
- Effects of i.v. amino acids on human splanchnic and whole body oxygen consumption, blood flow, and blood temperatures. (1994) (40)
- Amino acid metabolism in McArdle's syndrome. (1973) (40)
- Unordered structure of proinsulin C-peptide in aqueous solution and in the presence of lipid vesicles (2000) (40)
- LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES (1978) (40)
- Separate functional features of proinsulin C-peptide (2005) (39)
- Early microvascular dysfunction in healthy normal-weight males with heredity for type 2 diabetes. (2005) (39)
- C-Peptide Increases Na,K-ATPase Expression via PKC- and MAP Kinase-Dependent Activation of Transcription Factor ZEB in Human Renal Tubular Cells (2011) (39)
- Protein and amino acid metabolism during early starvation as reflected by excretion of urea and methylhistidines. (1989) (39)
- Insulin binding monitored by fluorescence correlation spectroscopy (2001) (38)
- Substrate Turnover during Prolonged Exercise in Man (38)
- Influence of branched-chain amino acid infusion on arterial concentrations and brain exchange of amino acids in patients with hepatic cirrhosis (1981) (37)
- Nicotine and related alkaloids : absorption, distribution, metabolism, and excretion (1993) (37)
- Hepatic glucose production and splanchnic glucose exchange in hyperthyroidism. (1986) (37)
- Influence of a mixed meal on splanchnic and interscapular energy expenditure in humans. (1991) (37)
- Symposium I: hormone-fuel interactions in normal and diabetic man. The liver as site of insulin and glucagon action in normal, diabetic and obese humans. (1975) (36)
- Renal Substrate Exchange in Human Diabetes Mellitus (1975) (36)
- Human forearm muscle metabolism during exercise. VII. FFA uptake and oxidation at different work intensities. (1972) (35)
- Brain substrate utilization during prolonged exercise. (1972) (35)
- Intravenous and subcutaneous administration of a long‐acting somatostatin analogue: effects on glucose metabolism and splanchnic haemodynamics in healthy subjects (1989) (34)
- Nonproductive exchanges: the use of isotopes gone astray. (1992) (34)
- Influence of C‐peptide on early glomerular changes in diabetic mice (2006) (34)
- Influence of growth hormone on splanchnic glucose production in man. (1977) (34)
- Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state. (1989) (34)
- Effects of captopril on hepatic venous pressure and blood flow in patients with liver cirrhosis. (1984) (33)
- Beta-adrenergic blockade does not influence the thermogenic response to a mixed meal in man. (1989) (32)
- Influence of protein ingestion on human splanchnic and whole-body oxygen consumption, blood flow, and blood temperature. (1994) (32)
- Human forearm muscle metabolism during exercise. IV. Glucose uptake at different work intensities. (1970) (32)
- Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats. (1996) (31)
- Interrelationship Between Amino Acid and Carbohydrate Metabolism During Exercise: The Glucose Alanine-Cycle (1971) (31)
- Meal-induced rise in resting energy expenditure in patients with complete cervical spinal cord lesions (1993) (31)
- Turnover of plasma-free arachidonic and oleic acids in resting and exercising human subjects. (1975) (31)
- Diminished skin blood flow in Type I diabetes: evidence for non-endothelium-dependent dysfunction. (2001) (30)
- Total and net muscle protein breakdown in infection determined by amino acid effluxes. (1990) (30)
- Can C‐peptide mediated anti‐inflammatory effects retard the development of microvascular complications of type 1 diabetes? (2013) (30)
- C-Peptide and Its C-Terminal Fragments Improve Erythrocyte Deformability in Type 1 Diabetes Patients (2008) (30)
- C-peptide fragments stimulate glucose utilization in diabetic rats (2004) (30)
- Lactate and pyruvate formation and oxygen utilization in the human forearm muscles during work of high intensity and varying duration. (1962) (29)
- Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation. (1999) (29)
- Influence of Body Position on the Anginal Threshold during Leg Exercise (1974) (29)
- Studies on the peripheral circulation and metabolism in man. IV. Oxygen utilization and lactate formation in the legs of healthy young men during strenuous exercise. (1965) (29)
- Influence of Arginine on Splanchnic Glucose Metabolism in Man (1979) (27)
- Arterial KIC as marker of liver and muscle intracellular leucine pools in healthy and type 1 diabetic humans. (1999) (26)
- Phosphagen and carbohydrate metabolism during exercise in trained middle-aged men. (1974) (26)
- Intravenous infusion of alpha-oxoisocaproate: influence on amino acid and nitrogen metabolism in patients with liver cirrhosis. (1982) (26)
- Use of 14CO2 in estimating rates of hepatic gluconeogenesis. (1992) (26)
- Effect of medium‐ and long‐chain triglyceride infusion on lipoprotein and hepatic lipase in healthy subjects (1991) (26)
- Effects of oral vs. i.v. glucose administration on splanchnic and extrasplanchnic O2 uptake and blood flow. (1996) (25)
- 40th EASD Annual Meeting of the European Association for the Study of Diabetes (2004) (25)
- Efficacy of a long‐acting C‐peptide analogue against peripheral neuropathy in streptozotocin‐diabetic mice (2015) (25)
- Does C-peptide have a physiological role? (1994) (25)
- Muscle Fiber Characteristics in Healthy Men and Patients with Juvenile Diabetes (1979) (25)
- C-peptide: A new potential in the treatment of diabetic nephropathy (2001) (24)
- C-Peptide: the missing link in diabetic nephropathy? (2009) (24)
- Splanchnic and Leg Metabolism of Glucose, Free Fatty Acids and Amino Acids during Prolonged Exercise in Man (1975) (24)
- Utilization of intravenously administered N-acetyl-L-glutamine in humans. (1989) (24)
- The Regulation of Splanchnic Glucose Production in Subjects with Low Insulin Response – a Compensatory Mechanism in Prediabetes? (1973) (24)
- Splanchnic and Leg Metabolism of Glucose, Free Fatty Acids and Amino Acids during Prolonged Exercise in Man (1975) (24)
- Plasma lipolytic activity and substrate oxidation after intravenous administration of heparin and a low molecular weight heparin fragment. (1990) (23)
- Amino acids in liver disease (1983) (23)
- Metabolic adaptation to prolonged starvation in man. (1970) (21)
- Labeling of human C‐peptide by conjugation with N‐succinimidyl‐4‐[18F]fluorobenzoate (2001) (21)
- Evanescent effects of hypo- and hyperglucagonemia on blood glucose homeostasis. (1976) (21)
- Ernst-Friedrich-Pfeiffer Memorial Lecture. New aspects of C-peptide physiology. (1998) (21)
- Turnover of free fatty acids during recovery from exercise. (1975) (21)
- Splanchnic blood flow and oxygen uptake during cardiopulmonary bypass. (2002) (21)
- Human forearm muscle metabolism during exercise. I. Circulatory adaptation to prolonged forearm exercise. (1968) (21)
- Regulation of amino acid metabolism by epinephrine. (1990) (21)
- Diminished meal-induced thermogenesis in elderly man. (1990) (20)
- Meal-induced thermogenesis in previously obese patients. (1990) (20)
- THE ORIGIN OF BLOOD WITHDRAWN FROM DEEP FOREARM VEINS DURING RHYTHMIC EXERCISE. (1964) (20)
- Free fatty acid metabolism of leg muscles during exercise in patients with obliterative iliac and femoral artery disease before and after reconstructive surgery. (1972) (20)
- Crossing the barrier: Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M500024-JLR200 net flux of 27-hydroxycholesterol into the human brain (2005) (20)
- Hepatic extraction and renal production of 3,3'-diiodothyronine and 3',5'-diiodothyronine in man. (1980) (19)
- Leucine uptake by splanchnic and leg tissues in man: relative independence of insulin levels. (1983) (19)
- C‐peptide makes a comeback (2003) (19)
- Muscle metabolism during exercise in patients with Parkinson's disease. (1974) (19)
- Nicotine and Related Alkaloids (1993) (18)
- Influence of hypoglucagonemia on splanchnic glucose output during leg exercise in man (1981) (18)
- Metabolic, thermal and circulatory effects of intravenous infusion of amino acids in tetraplegic patients. (1995) (18)
- Meal-induced thermogenesis in obese patients before and after weight reduction. (1989) (17)
- Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes? (2012) (17)
- Blood flow, substrate utilization and heat generation in tissues drained by the azygos vein in man. (1987) (17)
- The physiological impact of proinsulin C-peptide (1999) (17)
- Influence of vasoactive intestinal polypeptide (VIP) on splanchnic and central hemodynamics in healthy subjects (1989) (17)
- Glucose-induced thermogenesis in tetraplegic patients with low sympathoadrenal activity. (1994) (16)
- Quantitation of the pathways followed in the conversion of fructose to glucose in liver. (1993) (16)
- Fructose-6-phosphate cycling and the pentose cycle in hyperthyroidism. (1990) (16)
- Integrated bioprocess for production of human proinsulin C-peptide via heat release of an intracellular heptameric fusion protein. (2000) (16)
- Gene fragment polymerization gives increased yields of recombinant human proinsulin C-peptide. (1998) (15)
- Simultaneous uptake and release of individual free fatty acids in human forearm muscle during exercise. (1966) (15)
- C‐peptide and the pathophysiology of microvascular complications of diabetes (2017) (15)
- Splanchnic and peripheral glucose metabolism in cirrhosis. (1994) (15)
- The structure, molecular interactions and bioactivities of proinsulin C-peptide correlate with a tripartite molecule (2014) (14)
- Summary of the Conference on Diabetes and Exercise Sponsored by the Kroc Foundation and held in Santa Ynez, California, March 13–17, 1978 (1979) (14)
- Diet-induced thermogenesis in well-trained subjects. (1989) (13)
- Hepatic gluconeogenesis and ketogenesis in hyperthyroidism. (1981) (13)
- Human forearm muscle metabolism during exercise. 3. Uptake, release and oxidation of beta-hydroxybutyrate and observations on the beta-hydroxybutyrate/acetoacetate ratio. (1968) (13)
- Diet-induced thermogenesis in patients with liver cirrhosis. (1989) (12)
- Thermogenic response to intravenous nutrition in patients with cirrhosis. (1992) (12)
- In vivo biodistribution and pharmacokinetics of (18)F-labeled human C-peptide: evaluation in monkeys using positron emission tomography. (2002) (12)
- Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity (2004) (12)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- Biological Effects of C‐peptide and Proinsulin (2003) (11)
- Whole body and splanchnic metabolic and circulatory effects of glucose during beta-adrenergic receptor inhibition. (1997) (11)
- Glucose metabolism during physical exercise in patients with noninsulin-dependent (type II) diabetes. (1993) (11)
- Enhanced insulin action following subcutaneous co‐administration of insulin and C‐peptide in rats (2014) (10)
- Renal and splanchnic exchange of human biosynthetic C-peptide in Type 1 (insulin-dependent) diabetes mellitus (1991) (10)
- Infusion of ornithine-alpha-ketoglutarate in healthy subjects: effects on protein metabolism. (1985) (10)
- Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients (1995) (10)
- A versatile technique for multichannel, digital blood temperature recording in man. (1987) (10)
- Somatostatin and diabetes: suppression of glucose absorption rather than stimulation of glucose disposal. (1976) (9)
- Proinsulin C-peptide - A Consensus Statement (2001) (9)
- Influence of contraceptive steroids on the turnover of plasma free arachidonic and oleic acids. (1977) (9)
- C-peptide and Neuropathy in Type 1 Diabetes (2007) (9)
- Effects of nutrition and diabetes mellitus on the regulation of metabolic fuels during exercise. (1989) (9)
- Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation. (1999) (9)
- Effect of C-peptide on insulin and glucagon release by isolated perfused rat pancreas. (1997) (9)
- Role of cyclic AMP in glucagon-induced stimulation of hepatic glucose output in man. (1979) (9)
- Effect of carnitine supplemented TPN on turnover and muscle utilisation of free fatty acids in patients with persistent post-operative infection. (1989) (8)
- Effect of exercise on splanchnic exchange of free fatty acids. (1973) (8)
- Muscle metabolism during exercise in patients with occlusive arterial disease: effect of reconstructive surgery. (1973) (8)
- Hepatic disposal of endogenous growth hormone and prolactin in man (1979) (8)
- Glucose and free fatty acid utilization in exercise. Studies in normal and diabetic man. (1975) (8)
- Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD (2010) (7)
- Blood flow, oxygen uptake and lactate production in the forearm during exercise induced by median nerve stimulation. (1969) (7)
- Splanchic glucose production and its regulation in healthy monozygotic twins of diabetics. (1973) (6)
- Protein synthesis in skeletal muscle during starvation and refeeding: comparison of data from intact muscle and muscle biopsy material. (1990) (6)
- Experimental studies on the metabolic effects of branched chain amino acids. (1980) (6)
- Influence of fibre ingestion on carbohydrate utilization and absorption. (1982) (6)
- Somatostatin and diabetes mellitus: the role of glucagon in diabetic hyperglycemia and glucose intolerance. (1976) (6)
- Amino acid metabolism in patients with a hereditary myopathy and paroxysmal myoglobinuria. (2009) (6)
- Turnover of plasma free stearic and oleic acids in resting and exercising human subjects. (1975) (6)
- C-Peptide is Relevant in Type 1 Diabetes and its Complications: Summary and Conclusions to the Special Issue. (2009) (5)
- Hypoxemia cured by liver transplantation. (1990) (5)
- A dye dilution method for the determination of brachial artery blood flow during forearm exercise in man. (1965) (5)
- Precise determination of glucose-d2/glucose ratio in human serum and plasma by APCI LC-MS/MS (2009) (5)
- A simplified procedure for the calculation of cardiac output from dye dilution curves. (2009) (5)
- Effect of indomethacin on leg exchange of amino-acids in septic traumatised patients (1988) (5)
- New methods for probing the disposition of nicotine in humans (1993) (4)
- Substrate utilization in paretic human forearm muscle during electrically induced exercise. (1971) (4)
- Normalization of hepatic glucose regulation despite systemic insulin delivery. Studies in patients with pancreatic transplantation for Type 1 (insulin-dependent) diabetes mellitus (1991) (4)
- Hepatic glucose and amino acid metabolism in diabetes. (1972) (4)
- Substrate metabolism during exercise in normal and diabetic man. (1982) (4)
- Amino acid metabolism during exercise in McArdle's syndrome: evidence of altered alanine metabolism. (1972) (4)
- The Missing Link in Diabetic Nephropathy? (2010) (4)
- Triglyceride, free fatty acid and carbohydrate metabolism in hyperlipaemic (type IV) and normolipaemic subjects on carbohydrate- of fat-rich diets. (1975) (4)
- Role of basal glucagon levels in the regulation of splanchnic glucose output and ketogenesis in insulin-deficient humans. (1984) (3)
- LEG GLUCOSE UPTAKE DURING MAXIMAL EXERCISE IN HUMANS (1986) (3)
- Measurement of azygos venous blood flow by a continuous thermal dilution technique. (1986) (3)
- The biochemical basis of splanchnic thermogenesis. (1993) (3)
- [Leg blood supply during exercise: methodological studies with a dye dilution technic]. (1971) (3)
- Metabolism of Free Fatty Acids During Exercise in Patients with Occlusive Arterial Disease of the Leg (1971) (3)
- Exercise and diabetes: an overview. (1979) (3)
- [Severe malnutrition in a middle aged man with anorexia nervosa]. (1971) (3)
- [Influence of protein ingestion on the amino acid metabolism in diabetes mellitus]. (1976) (3)
- Splanchnic extraction of 3,3'-diiodothyronine and 3',5'-diiodothyronine in hyperthyroidism. (1984) (2)
- Large-surface biosensor technology for enhanced recovery in protein characterization. (2005) (2)
- Free fatty acid and ketone body utilization under normal and pathophysiological conditions. (1981) (2)
- The relevance of C-Peptide in diabetes and its complications: an introduction to the special issue. (2009) (2)
- Diabetes and Physical Exercise (1984) (2)
- The effect of carnitine supplementation on carnitine balance in patients with persistent post-operative infection. (1990) (2)
- Leg blood flow during exercise in patients with occlusion of the iliac artery: pre- and postoperative studies. (1973) (2)
- Do Branched-Chain Amino Acids Have a Role in the Treatment of Hepatic Encephalopathy? (1984) (2)
- BLOOD FLOW IN THE EXTREMITIES AT REST, DURING REACTIVE HYPERAEMIA AND AFTER GANGLIONIC BLOCK IN CASES OF FRIEDREICH'S ATAXIA. (2009) (2)
- Serum lipid and lipoprotein levels in female type I diabetics: relationships to aerobic capacity and glycaemic control. (1987) (2)
- Carbohydrate homeostasis and the liver. (2009) (2)
- Simultaneous measurements of external iliac artery and vein blood flow after reconstructive vascular surgery: evidence of increased collateral circulation during exercise. (1973) (1)
- Severe malnutrition in a middle-aged man with anorexia nervosa. (1971) (1)
- Arterial KIC as marker of liver and muscle intracellular leucine pools in healthy and type 1 diabetic humans. (1999) (1)
- FREE FATTY ACID AND KETONE BODY METABOLISM DURING EXERCISE IN DIABETES (1980) (1)
- Direct effect of insulin on the β-cell function (1978) (1)
- Paroxysmal ventricular tachycardia without organic heart disease. A case report describing its provocation and five-year follow-up. (2009) (1)
- [Passive smoking: a more objective approach is needed]. (1994) (1)
- DETERMINATION OF LEG BLOOD FLOW DURING TECHNIQUE BASED ON FEMORAL VENOUS DYE INFUSION EXERCISE IN MAN: AN INDICATOR-DILUTI ON (1973) (1)
- Glucose Metabolism in Exercising Man (1992) (1)
- Glucose Metabolism during Leg Exercise in Man 2717 (1)
- Annual Meeting of the Scandinavian Society for the Study of Diabetes (1972) (1)
- [Brain substrate utilization in man during work]. (1971) (1)
- Does It Make Sense to Screen for Celiac Disease in Children and Adolescents with Type 1 Diabetes ? (1998) (1)
- In vivo evaluation of fluorine-18 labelled human proinsulin connecting peptide (C-Peptide) in monkey using PET (2000) (1)
- 招待講演 Metabolic Adaptation to Physical Exercise in Diabetes Mellitus (1980) (1)
- Renoprotective Effects of C-Peptide on Type 1 Diabetes (2012) (1)
- Sites and mechanism of insulin (I)-mediated potassium (K) metabolism in man (1979) (1)
- PROINSULIN C-PEPTIDE CAN INHIBIT THE EARLY CHANGES OF GLOMERULOPATHY IN DIABETIC MICE (2004) (1)
- [Average body weight and correlation weight in relation to age and sex]. (1981) (1)
- Fourth meeting of the Scandinavian Society for the Study of Diabetes Stockholm, February 1–3, 1968 Abstracts (1968) (1)
- ANGINA DURING ARM AND LEG EXERCISE Table 1 Summary of Clinical History and Findings History of Pain on Age Height Weight chest pain Exposure Postprandial History Patient (2005) (0)
- Preparations of pro-insulin c-peptide with delayed release (2006) (0)
- Effects of local cooling on muscle power and movement size in patients with spastic paresis (1970) (0)
- How Effective Are Branched Chain Amino Acids in the Treatment of Patients with Liver Cirrhosis (1984) (0)
- [Branched-chain amino acids for patients with liver disease--an effective treatment or scientific humbug?]. (1984) (0)
- O.68 Exchange of amino acids and nitrogenous compounds by the brain in man (1983) (0)
- [Substrate metabolism of the skeletal musculature during exercise. 7. Amino acids]. (1972) (0)
- fasting: significance in gluconeogenesis quantitation Origins of the hydrogen bound to carbon 1 of glucose in (2016) (0)
- [Consumption and oxidation of free fatty acids in skeletal muscle during work with different intensity]. (1970) (0)
- Influence of Body Position on the Anginal Threshold during Leg Exercise (1974) (0)
- Pilot Data on Brain-to-Blood Efflux of B-Amyloid Peptides in Man (2014) (0)
- P1-392 Oxysterol crosstalk at the blood-brain barrier (2006) (0)
- [Importance and methods of epidemiological studies in mass x-ray examinations (author's transl)]. (1980) (0)
- Metabolic Effects of Physical Exercise and Training in Diabetes mellitus (1990) (0)
- [Body height relationships in women and men]. (1980) (0)
- ACKNOWLEDGEMENTS (1964) (0)
- The role of the liver in the regulation of glucose homeostasis in man. (1980) (0)
- [Tension-time-index and pain reaction in arm and leg work in patients with angina pectoris]. (1970) (0)
- To the Editor (0)
- Specific peptides for the treatment of diabetes mellitus (1996) (0)
- A dye dilution method for the determination of brachial artery blood flow during rhythmic exercise. (1967) (0)
- C-peptide induced transcription factor ZEB DNA binding and Na,K-ATPase α 1 -subunit mRNA expression. (2013) (0)
- [Actions of the tobacco industry and Swedish physicians]. (2002) (0)
- Discussion (1980) (0)
- Novel therapeutic approach to microvascular complications of type 1 diabetes (2013) (0)
- THE EFFECT OF LIDOCAINE AND MEPIVACAINE ON THE FOREARM RESISTANCE AND CAPACITANCE VESSELS IN MAN (1970) (0)
- Pitfalls in the Evaluation of Therapeutic Effects in Patients with Hepatic Encephalopathy (1984) (0)
- Hepatic Glucose Production: Sensitivity to Endogenous Insulin Secretion in Man. (1971) (0)
- Myocardial metabolism of FFA in resting man. (1970) (0)
- C-peptide: a new potential in the therapy of microvascular complications of Type 1 diabetes? (2015) (0)
- Investigation of Metabolic Changes During Exercise Using the Hepatic Venous Catheter Technique (1981) (0)
- C-Peptide and Diabetic Neuropathy in Patients with Type 1 Diabetes (2012) (0)
- Response to above letter (1990) (0)
- [Symposium concerning methods of estimation of blood circulation in extremities during muscle work. 1. Color dilution technic]. (1970) (0)
- Protein Dynamics in the Splanchnic Region in Humans (1994) (0)
- [Free fatty acid metabolism in leg muscles during work in patients with intermittent claudication]. (1970) (0)
- [Factors contributing to diabetes onset in prediabetic subjects]. (1972) (0)
- Contributory presentations/posters (1999) (0)
- Limitations in estimating gluconeogenesis and Cori cycling from mass isotopomer distributions using [U-13C6]glucose. (1998) (0)
- Reply (1990) (0)
- Importance of route of glucose administration for hepatic glucose uptake in healthy subjects (1978) (0)
- 1999 XIII International Biophysics Congress 19-24 September 1999 New Delhi Abstracts Suppl (2016) (0)
- Inter-Organ Flux of Ammonia during Physical Exercise (1984) (0)
- Applications therapeutiques pour peptide c (2004) (0)
- [Effect of local anesthetics on central and peripheral circulation]. (1970) (0)
- Eighth annual meeting of the European Association for the Study of Diabetes (1973) (0)
- [Substrate metabolism of the skeletal musculature during exercise. 4. Glucose]. (1972) (0)
- [Substrate utilization of the lower arm muscles during electrically induced work in patients with paresis]. (1971) (0)
- DO NOT DISTRIBUTE: FOR OGSP WORKSHOP PARTICIPANTS ONLY Figure 1. Relative Binding Affinities of ANP Receptors for Natriuretic Peptides (2007) (0)
- [C-peptide, new discoveries and therapeutic implications]. (1999) (0)
- [Substrate utilization of the lower arm muscles at rest and during work in long term fasting]. (1971) (0)
- S-76-3 Nicotine abstinence affects the cerebral attention system (1996) (0)
- special communication Quantifying gluconeogenesis during fasting (1997) (0)
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