John K. Westwick
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Biology
John K. Westwick's Degrees
- Masters Biochemistry Stanford University
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)John K. Westwick's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K (1997) (778)
- Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. (1990) (709)
- Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways (1997) (484)
- Chemokines and T lymphocytes: more than an attraction. (1998) (462)
- IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. (2014) (459)
- Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation* (1997) (405)
- Ceramide Activates the Stress-activated Protein Kinases (*) (1995) (379)
- Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation (1996) (367)
- Lck regulates Vav activation of members of the Rho family of GTPases (1997) (343)
- The coupling of α6β4 integrin to Ras–MAP kinase pathways mediated by Shc controls keratinocyte proliferation (1997) (331)
- Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway* (1999) (319)
- Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. (2001) (298)
- Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. (1994) (293)
- The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. (1999) (288)
- Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation (2014) (283)
- Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth (2010) (266)
- L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. (1997) (264)
- Identifying off-target effects and hidden phenotypes of drugs in human cells (2006) (253)
- IL-4 inhibits the expression of IL-8 from stimulated human monocytes. (1990) (241)
- A novel murine model of severe pulmonary arterial hypertension. (2011) (229)
- Chemokines: understanding their role in T-lymphocyte biology. (1998) (212)
- JNK mediates hepatic ischemia reperfusion injury. (2005) (202)
- The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α* (1998) (189)
- Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. (1994) (189)
- Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. (1999) (188)
- Low-molecular-weight heparin and prevention of postoperative deep vein thrombosis. (1982) (184)
- Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass. (1993) (182)
- RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase. (1995) (162)
- Human vascular smooth muscle cells express receptors for CC chemokines. (1998) (160)
- Isolation of a NCK-associated Kinase, PRK2, an SH3-binding Protein and Potential Effector of Rho Protein Signaling* (1996) (158)
- Activation of Jun kinase is an early event in hepatic regeneration. (1995) (157)
- Human peritoneal mesothelial cells synthesize interleukin-8. Synergistic induction by interleukin-1 beta and tumor necrosis factor-alpha. (1993) (157)
- Chemokine gene expression and secretion by cytokine-activated human microvascular endothelial cells. Differential regulation of monocyte chemoattractant protein-1 and interleukin-8 in response to interferon-gamma. (1994) (156)
- Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes (2013) (156)
- Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma1 (2001) (154)
- Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines (1998) (153)
- SMAD and p38 MAPK Signaling Pathways Independently Regulate α1(I) Collagen Gene Expression in Unstimulated and Transforming Growth Factor-β-stimulated Hepatic Stellate Cells* (2005) (149)
- Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. (1994) (137)
- Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-B-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation (*) (1996) (136)
- Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation (1993) (131)
- TLR9 Differentiates Rapidly from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis (2010) (131)
- The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. (1994) (122)
- Chemokines: new ligands, receptors and activities. (1995) (122)
- Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumor necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist. (1993) (121)
- Novel neutrophil-stimulating peptides. (1989) (120)
- Human cytomegalovirus infection up‐regulates interleukin‐8 gene expression and stimulates neutrophil transendothelial migration (1997) (117)
- The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. (1997) (110)
- p120 GAP Modulates Ras Activation of Jun Kinases and Transformation* (1997) (108)
- The Role of the CCL2/CCR2 Axis in Mouse Mast Cell Migration In Vitro and In Vivo (2010) (96)
- Chemokine production by human vascular smooth muscle cells: modulation by IL‐13 (1997) (96)
- Activation of Human TRPC6 Channels by Receptor Stimulation* (2004) (94)
- Activation of Phosphatidylinositol 3-Kinase by Interleukin-13 (1997) (94)
- Cytokine-induced Apoptosis in Epithelial HT-29 Cells Is Independent of Nitric Oxide Formation (1999) (93)
- Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation* (2002) (92)
- Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. (2004) (92)
- A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13) (2017) (91)
- Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH2-terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun* (1998) (91)
- Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics. (1997) (90)
- Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8. (1991) (90)
- Potent and specific inhibition of IL-8-, IL-1α- and IL-1β-inducedin vitro human lymphocyte migration by calcium channel antagonists (1989) (88)
- Inhibition of CD28‐mediated T cell costimulation by the phosphoinositide 3‐kinase inhibitor wortmannin (1995) (88)
- Phosphoinositide Lipid Phosphatases: Natural Regulators of Phosphoinositide 3-Kinase Signaling in T Lymphocytes* (2008) (86)
- The p65/RelA Subunit of NF-κB Suppresses the Sustained, Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor (2002) (86)
- L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. (1995) (85)
- A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with marfan and loeys–dietz syndrome (2013) (84)
- Oncogenic ras induces gastrin gene expression in colon cancer. (1998) (84)
- IL-1 receptor antagonist inhibits monocyte chemotactic peptide 1 generation by human mesangial cells. (1992) (83)
- Notch signaling mediates TGF-β1-induced epithelial-mesenchymal transition through the induction of Snai1. (2012) (82)
- Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac (1998) (79)
- Receptor-operated Ca2+ influx channels in leukocytes: a therapeutic target? (2002) (76)
- Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. (1995) (75)
- Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases (2005) (75)
- Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. (1989) (75)
- Investigation of the Interaction of Blood Platelets with the Coagulation System at the Site of Plug Formation In Vivo in Man - Effect of Low-Dose Aspirin (1987) (75)
- Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT‐29 (1995) (73)
- Inhibition of Tumor Growth, Angiogenesis, and Tumor Cell Proliferation by a Small Molecule Inhibitor of c-Jun N-terminal Kinase (2005) (72)
- Platelet activation during steady state sickle cell disease. (1983) (70)
- THE ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITIS (1974) (69)
- Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays. (2004) (65)
- Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. (1986) (63)
- Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels (1995) (63)
- Transient receptor potential (TRP) channels as potential drug targets in respiratory disease. (2003) (62)
- Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. (2014) (60)
- Regulation and expression of chemokines: potential role in glomerulonephritis (1996) (59)
- Ras-mediated transcription activation: analysis by transient cotransfection assays. (1995) (55)
- Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. (2013) (55)
- Expression of transient receptor potential C6 channels in human lung macrophages. (2010) (54)
- C‐X‐C and C‐C chemokine expression and secretion by the human colonic epithelial cell line, HT‐29: differential effect of T lymphocyte‐derived cytokines (1999) (54)
- Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation. (1986) (52)
- Characterization of platelet‐activating factor‐induced elevation of cytosolic free calcium concentration in eosinophils (1989) (51)
- Interleukin 8 and monocyte chemoattractant protein 1 production by cultured human airway smooth muscle cells. (1998) (51)
- The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. (2011) (51)
- Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1992) (50)
- [35] Methods for analyzing c-Jun kinase (1995) (49)
- PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA. (2007) (48)
- Activation of activating protein 1 during hepatic acute phase response. (1993) (47)
- ADP metabolism in vascular tissue, a possible thrombo-regulatory mechanism. (1979) (46)
- Measuring drug action in the cellular context using protein-fragment complementation assays. (2003) (46)
- beta-thromboglobulin and platelet factor 4 levels in retinal vein occlusion. (1983) (44)
- IL-15 complexes induce NK cell and T cell responses independent of type I IFN signalling during rhinovirus infection (2014) (43)
- Recombinant guinea pig and human RANTES activate macrophages but not eosinophils in the guinea pig. (1997) (42)
- Do prostacyclin and thromboxane play a role in endotoxic shock? (1981) (42)
- Endothelin induces an increase in renal vascular resistance and a fall in glomerular filtration rate in the rabbit isolated perfused kidney (1989) (42)
- Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice (1982) (41)
- Interleukin‐8 production by the human colon epithelial cell line HT‐29: modulation by interleukin‐13 (1996) (40)
- Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase (2010) (39)
- Tyrosine-kinase activity in rabbit platelets stimulated with platelet-activating factor. The effect of inhibiting tyrosine kinase with genistein on platelet-signal-molecule elevation and functional responses. (1993) (39)
- Interleukin-1-induced IL-8 and IL-6 gene expression and production in human mesangial cells is differentially regulated by cAMP. (1995) (37)
- Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line. (1987) (37)
- Anti-inflammatory actions of interleukin-13: suppression of tumor necrosis factor-alpha and antigen-induced leukocyte accumulation in the guinea pig lung. (1999) (35)
- EFFECTS OF PROSTAGLANDINS E2 AND I2 ON HUMAN LYMPHOCYTE TRANSFORMATION IN THE PRESENCE AND ABSENCE OF INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS (1979) (35)
- Structural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: recognition by cerebellar and platelet inositol-1,4,5-trisphosphate receptors. (1997) (34)
- ENHANCED IN-VIVO PLATELET RELEASE REACTION, INCREASED THROMBOXANE SYNTHESIS, AND DECREASED PROSTACYCLIN RELEASE AFTER TOURNIQUET ISCHAEMIA (1980) (33)
- Airway inflammation induced by recombinant guinea pig tumor necrosis factor-alpha. (1997) (32)
- Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. (2006) (32)
- Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. (1993) (32)
- Cyclosporin therapy in vivo attenuates the response to vasodilators in the isolated perfused kidney of the rabbit (1989) (31)
- Elevation of PMN cytosolic free calcium and locomotion stimulated by novel peptides from IL-1-treated human synovial cell cultures. (1988) (31)
- Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses. (1992) (30)
- Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. (1984) (30)
- Differential effects of protein kinase C inhibitors on chemokine production in human synovial fibroblasts (1996) (29)
- Antagonism of the platelet activating factor‐induced rise of the intracellular calcium ion concentration of U937 cells (1988) (29)
- The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules. (1991) (29)
- Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes. (2005) (28)
- Essential role of phosphoinositide 3‐kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation (2009) (28)
- Methods for analyzing c-Jun kinase. (1995) (27)
- Effect of corticosteroids on nitric oxide production in inflammatory bowel disease: are leukocytes the site of action? (2005) (27)
- Evidence That the Lipid Phosphatase SHIP-1 Regulates T Lymphocyte Morphology and Motility (2011) (27)
- Increased vascular permeability and polymorphonuclear leucocyte accumulation in vivo in response to recombinant cytokines and supernatant from cultures of human synovial cells treated with interleukin 1. (1989) (27)
- TRP channels as drug targets. (2004) (27)
- Analysis of a transformed cell line using antisense c-fos RNA. (1988) (27)
- Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on high-resolution CT imaging. (2014) (26)
- Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. (1996) (26)
- ENDOTHELIN AND CYCLOSPORIN NEPHROTOXICITY (1988) (26)
- Antibody ligation of CD7 leads to association with phosphoinositide 3‐kinase and phosphatidylinositol 3,4,5‐trisphosphate formation in T lymphocytes (1995) (26)
- CCR7 Deficiency on Dendritic Cells Enhances Fungal Clearance in a Murine Model of Pulmonary Invasive Aspergillosis1 (2009) (25)
- Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists. (1989) (24)
- Evidence for the presence and location of annexins in human platelets. (1992) (24)
- Neutrophil stimulation by recombinant cytokines and a factor produced by IL-1-treated human synovial cell cultures. (1988) (23)
- Mechanisms of Stimulus—Response Coupling in Platelets (1985) (23)
- Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. (2013) (22)
- Chemical genetic strategies to delineate MAP kinase signaling pathways using protein-fragment complementation assays (PCA). (2006) (21)
- L-arginine/nitric oxide pathway: a possible signal transduction mechanism for the regulation of the chemokine IL-8 in human mesangial cells. (1993) (21)
- Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. (1981) (21)
- Phorbol esters modulate thrombin-operated calcium mobilisation and dense granule release in human platelets. (1986) (20)
- Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes. (2011) (20)
- Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells. (2010) (20)
- Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. (1983) (19)
- The function of CCR3 on mouse bone marrow‐derived mast cells in vitro (2010) (19)
- Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28. (1997) (18)
- Structure activity relationships of 12-deoxyphorbol esters of human platelets. (1980) (18)
- Regional heterogeneity of endothelium‐dependent vasodilatation in the rabbit kidney. (1991) (17)
- Endothelin‐1 in the rabbit: interactions with cyclo‐oxygenase and NO‐synthase products (1993) (17)
- An X-ray analysis of adjuvant arthritis in the rat. The effect of prednisolone and indomethacin (1977) (17)
- In vivo platelet release reaction in patients with heart valve prosthesis. (1980) (17)
- Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation. (1994) (17)
- Effect of Pyridoxal 5'-Phosphate (PALP) on Human Platelet Aggregation, Dense Granule Release and Thromboxane B2 Generation - Role of Schiff Base Formation (1982) (17)
- hrIL‐8‐Induced Hyperresponsiveness in Guinea Pig Perfused Lungs (1991) (17)
- A role for protein phosphorylation in modulating Ca2+ elevation in rabbit platelets treated with thapsigargin. (1996) (17)
- The p 65 / RelA Subunit of NF-B Suppresses the Sustained , Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor (2002) (16)
- Inhibition by staurosporine of mitogen‐induced calcium mobilisation in human T lymphoblasts (1988) (16)
- Genetic ablation of PI3Kγ results in defective IL‐17RA signalling in T lymphocytes and increased IL‐17 levels (2012) (16)
- Selective antagonism of prostaglandin (PG) E1, PGD2 and prostacyclin (PGI2) on human and rabbit platelets by di-4-phloretin phosphate (DPP). (1978) (15)
- Therapeutic scope of modulation of non-voltage-gated cation channels. (2005) (15)
- Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets. (1994) (15)
- Interleukin-8--a mediator of inflammatory lung disease? (1991) (15)
- Nicotinic acetylcholine receptors in primary cultures of hippocampal neurons: pharmacology and Ca++ permeability. (1994) (15)
- Phorbol esters regulate CD2- and CD3-mediated calcium responses in peripheral blood-derived human T cells. (1989) (15)
- Phosphoinositide 3-Kinase Alpha-Dependent Regulation of Branching Morphogenesis in Murine Embryonic Lung: Evidence for a Role in Determining Morphogenic Properties of FGF7 (2014) (14)
- The protein phosphatase inhibitor calyculin A stimulates chemokine production by human synovial cells. (1995) (14)
- Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells. (2005) (14)
- The effect of pulmonary metabolites of prostaglandins E1, E2 and F2alpha on ADP-induced aggregation of human and rabbit platelets [proceedings]. (1976) (14)
- D-myo-Inositol 1,4,5-Trisphosphate Analogues Modified at the 3-Position Inhibit Phosphatidylinositol 3-Kinase (*) (1995) (13)
- Protein-fragment complementation assays (PCA) in small GTPase research and drug discovery. (2006) (13)
- Responses to Endothelins‐1, −2, and −3 and Sarafotoxin 6c After Ischemia/Reperfusion in Isolated Perfused Rat Heart: Role of Vasodilator Loss (1995) (13)
- Synthesis of 1L-chiro-inositol 2,3,5-trisphosphorothioate, the first partial agonist at the platelet myo-inositol 1,4,5-trisphosphate receptor. (1994) (13)
- 6-Deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate: A potent agonist at the inositol 1,4,5-trisphosphate receptor (1996) (13)
- A role for RANTES in T lymphocyte proliferation. (1996) (12)
- A role for phosphoinositide 3--kinase in RANTES induced chemotaxis of T lymphocytes. (1995) (12)
- Intraperitoneal Injection of Human Recombinant Neutrophil‐Activating Factor/Interleukin 8 (hrNAF/IL‐8) Produces a T Cell and Eosinophil Infiltrate in the Guinea Pig Lung. Effect of PAF Antagonist WEB2086 (1991) (12)
- Improving drug discovery with contextual assays and cellular systems analysis. (2011) (12)
- The whoosh and trickle of calcium signalling. (1995) (12)
- Effects of Anti-IL-13 (Novartis QAX576) on Inflammatory Responses Following Nasal Allergen Challenge (NAC). (2009) (12)
- Interleukin-13 inhibits nitric oxide production in human colonic mucosa. (2000) (11)
- Myo-inositol 1,4,6-trisphosphate: A new synthetic Ca2+-mobilising inositol phosphate (1993) (11)
- Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels (2009) (11)
- Therapeutic modulation of inflammatory gene transcription by kinase inhibitors (2002) (10)
- Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6 -trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors. (1996) (10)
- Chemotactic cytokines. Biology of the inflammatory peptide supergene family. Proceedings of the Second International Symposium on Chemotactic Cytokines. June 25-26, 1990, London, United Kingdom. (2012) (10)
- Disparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes (2000) (10)
- Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases (2017) (10)
- Microvascular responses produced by the prostaglandin endoperoxide PGG2 in vivo [proceedings]. (1977) (10)
- The Chemokines : biology of the inflammatory peptide supergene family II (1993) (9)
- Myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3,4-trisphosphorothioate: New synthetic Ca2+-mobilising partial agonists at the inositol 1,4,5-trisphosphate receptor (1995) (9)
- myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor. (2000) (9)
- Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid. (1991) (9)
- Comparison Of Effects Of Imatinib And Nilotinib In A Rodent Model Of Pulmonary Arterial Hypertension (2010) (8)
- Therapeutic scope of modulation of non-voltage-gated cation channels. (2004) (8)
- Inhibition of thromboxane formation prevents endotoxin-induced renal fibrin deposition in jaundiced rats. (1983) (8)
- Human recombinant neutrophil-activating factor/interleukin-8 is a spasmogen of airway smooth muscle in vitro. (1989) (8)
- Reversal of noradrenaline-induced constriction of hamster cheek pouch arterioles by prostaglandins and their metabolites. (1977) (8)
- The effect of daphnane esters on platelet aggregation and erythema of the mouse ear (1980) (7)
- Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy (2017) (7)
- Exploiting network biology to improve drug discovery. (2007) (7)
- Rabbit monoarticular arthritis and synovial prostaglandins. (1973) (6)
- Comparison of the effects of prostaglandin analogues on rabbit platelets, rabbit isolated vascular tissues and rabbit skin microvasculature [proceedings]. (1978) (6)
- Functional proteomics analysis of GTPase signaling networks. (2001) (6)
- Low Molecular Weight Heparin and the Prevention of Postoperative Deep Vein Thrombosis (1983) (5)
- ENDOTHELIN AND CYCLOSPORINE NEPHROTOXICITY (1988) (5)
- Potentiation of ADP-ase activity of aortic rings by prostaglandin synthetase inhibitors and PGE1 [proceedings]. (1977) (5)
- The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation. (1995) (5)
- Calcium release activity and metabolism of inositol 1,4,5-trisphosphate in T cells. Modulation by novel inositol 1,4,5-trisphosphate 5-phosphatase inhibitors. (1994) (5)
- Prostaglandins as mediators of inflammation--vascular aspects. (1979) (4)
- Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy (2021) (4)
- Proceedings: The effect of sulphinpyrazone, sodium aspirin and oxprenolol on the formation of arterial platelet thrombi. (1975) (4)
- Interleukin 8 (IL-8) is Produced by the Bronchoalveolar Lavage Cell Population from Patients with Active but not Inactive Sarcoidosis (1993) (4)
- Proceedings: Measurement of changes in the microvasculature. (1976) (4)
- Human mesangial cell-derived interleukin 8 and interleukin 6: modulation by an interleukin 1 receptor antagonist. (1991) (4)
- Modulation of thrombus formation in vivo by prostaglandins [proceedings]. (1977) (4)
- Role of endogenous arachidonate metabolites in phospholipid-induced human platelet activation. (1983) (4)
- Differential effect of platelet-activating factor receptor antagonists on human T-lymphocyte proliferation (1987) (3)
- Abstract of papers to be presented at the 31st annual scientific session of the American College of Cardiology Atlanta, Georgia, April 25–29, 1982The release of thromboxane during atrial pacing and the haemodynamic and metabolic effects of its inhibition by dazoxiben (1982) (3)
- An ATP receptor that mediates increases in intracellular calcium in U937 cells is a P2Y-purinoceptor (1990) (3)
- A Role for Platelet-Activating Factor (PAF) in Human T-Lymphocyte Proliferation (1987) (3)
- Raf-independent deregulation of p 38 and JNK kinases are critical for Ras transformation (2002) (3)
- Stimulation of signal transduction pathways by MCP-1 in human monocytes and THP-1 cells. (1996) (3)
- Vascular changes in rabbit skin induced by proinflammatory phorbol and 12-deoxyphorbol esters (1981) (3)
- Platelet-activating factor induces inositol 1,4,5 tris- and 1,3,4,5 tetrakis-phosphate production in U937 cells (1989) (3)
- Mechanisms of calcium homeostasis in the polymorphonuclear leucocyte (1986) (3)
- NFκB: A Key Integrator of Cell Signaling (2003) (3)
- Stimulation of tyrosine phosphorylation and phosphatidylinositol 3-kinase by MCP-1 in THP-1 cells. (1997) (3)
- cause tumorigenic transformation . kinase-independent pathways is sufficient to Raf / mitogen-activated protein Oncogenic Ras activation of (1996) (3)
- Intraperitoneal injection off neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) results in a lymphocyte and eosinophil infiltrate in the guinea-pig lung (1990) (2)
- The interaction of the tyrosine kinase pp60src with membrane and cytoskeletal components. (1993) (2)
- Phosphoinositide 3-Kinase Alpha-Dependent Regulation of Branching Morphogenesis in Murine Embryonic Lung : Evidence for a Role in Determining Morphogenic Properties of FGF 7 (2014) (2)
- Chemotactic Cytokines (1991) (2)
- Effect of SC 38249, a Novel Substituted Imidazole, on Platelet Aggregation In Vitro and In Vivo (1988) (2)
- SMAD and p38 MAPK Signaling Pathways Independently Regulate (cid:1) 1(I) Collagen Gene Expression in Unstimulated and Transforming Growth Factor- (cid:2) -stimulated Hepatic Stellate Cells* (2005) (2)
- myo-Inositol 1,4,6-Trisphosphorothioate and myo-Inositol 1,3,4- Trisphosphorothioate: New Synthetic Ca2+-Mobilizing Partial Agonists at the Inositol 1,4,5-Trisphosphate Receptor. (1995) (2)
- Imatinib Attenuates Hypoxia-Induced PAH Pathology Via Reduction In Serotonin Through Inhibition Of Tryptophan Hydroxylase 1 Expression (2012) (1)
- ofOphthalmology , 1983 , 67 , 143-146 f 3-Thromboglobulin and platelet factor 4 levels in retinal vein occlusion (1)
- RELEASE OF AN AGGREGATING SUBSTANCE BY HUMAN PLATELETS IN RESPONSE TO PHORBOL‐ESTER STIMULATION (1982) (1)
- IL-1 INDUCED IL-8 AND IL-6 EXPRESSION AND PRODUCTION IN HUMAN MESANGIAL CELLS (MC) IS DIFFERENTIALLY REGULATED BY CAMP (1995) (1)
- T5 Sampling Airway Mucosal Lining Fluid Identifies Roles For IL-33 and Multiple Inflammatory Pathways in Virus-Induced Asthma Exacerbations (2012) (1)
- Differential Stability Of Prostacyclin (PGI2) In Whole Blood And Plasma (1981) (1)
- Nasal and bronchial levels of Th2 cytokines correlate during a virus induced asthma exacerbation (2012) (1)
- The Roles Of TPH1, Serotonin And PDGF Within A Novel Murine Model Of Pulmonary Arterial Hypertension (2011) (1)
- The Effect of Sulfinpyrazone, Aspirin and their Metabolites on Prostacyclin Production by Rabbit Aortic Rings (1979) (1)
- PRO‐INFLAMMATORY AND TUMOUR PROMOTING PHORBOL AND 12‐DEOXYPHORBOL ESTER‐INDUCED CHANGES IN RABBIT SKIN MICROVASCULATURE (1980) (1)
- MYO-INOSITOL-1,4,6-TRISPHOSPHOROTHIOATE - AN INHIBITOR OF INOSITOL TRISPHOSPHATE-INDUCED CA-45(2+) RELEASE (1994) (1)
- Characterisation of platelet-activating factor-induced diacylglycerol generation in rabbit platelets. (1989) (1)
- Characterisation of platelet activating factor induced inositol (1, 4, 5)-trisphosphate production in platelets: modulation by protein kinase C (1990) (1)
- Intracellular localisation and functional properties of human TRPC7 (2004) (1)
- PMN stimulation by factors from IL-1-treated human synovial cell cultures (1989) (1)
- Single Oral Dose Administration Of A Specific Thromboxane Synthetase Inhibitor To Normal Volunteers - A Double Blind Placebo Controlled Study (1981) (1)
- Low Molecular Weight Heparin And Postoperative Deep Vein Thrombosis (1981) (1)
- Comparison of Sulfinpyrazone and its Metabolites on TxB2 and PGE2 Generation By Human Platelets (1979) (1)
- Proto-oncogenes/ transcription factors (1998) (1)
- Characterisation of a serine/threonine kinase which mediates CD28 phosphorylation following activation by B7.1. (1996) (1)
- Cloning and characterization of proteins that bind the sh3 domains of the nck adaptor protein (1996) (1)
- Imatinib As A Therapy For Pulmonary Arterial Hypertension - Insights Into Mechanism Of Action From Rodent Models (2012) (1)
- HUMAN BLOOD PLATELET AGGREGATION BY ESTERS OF 12‐DEOXYPHORBOL (1979) (1)
- Stimulation of platelets with platelet-activating factor induces changes in the subcellular distribution and activity of the tyrosine kinase pp60c-src. (1995) (1)
- Prostaglandins and model aspects of thrombosis. (1977) (1)
- Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus (2004) (0)
- The Effect of Prostaglandins G2, D2, E2, E1 and Arachidonic acid on Thrombus Formation in Vivo (1977) (0)
- CHAPTER 286 – NFκB: A Key Integrator of Cell Signaling (2003) (0)
- Prostaglandins that induce platelet aggregation: The role of thromboxane A2 (1981) (0)
- CYCLOSPORIN AND THE VASCULAR REACTIVITY OF ISOLATED PERFUSED RABBIT KIDNEYS (1988) (0)
- Prostaglandins andmodel aspects ofthrombosis (1977) (0)
- A reengineered common chain cytokine augments CD8+ T cell–dependent immunotherapy (2022) (0)
- Prostanoids And Endotoxaemia In The Mini-Pig (1981) (0)
- Reduction in serotonin signaling via TPH1 inhibition attenuates the progression of PAH in mice with genetic ablation of endothelial BMPR-II (2012) (0)
- Tumor necrosis factor-$alpha; stimulates AP-1 activity through phosphorylation of c-Jun (1993) (0)
- Platelet Function in Retinal Vein Occlusion (1982) (0)
- Histologically normal colonic biopsies from patients with colitis behave like inflamed colon not bowel from healthy individuals (1998) (0)
- A simple perfusion system for the study of histamine release from rat peritoneal mast cells (2006) (0)
- Endotoxin Inhibits Prostacyclin Release From Rabbit Aorta (1981) (0)
- Human Platelet Aggregation Without Thromboxane (Tx) Formation (1981) (0)
- Possible Mode Of Action Of A Semi-Synthetic Heparin Analogue . (SSHA) (1981) (0)
- Ca2+ release and binding studies of compounds structurally related to inositol 1,4,5-trisphosphate and adenophostin (1996) (0)
- Differential effect of IL-4, IL-10 & IL-13 on the production of IL-8 and nitric oxide in colonic biopsies from patients with colitis (1998) (0)
- Phosphoinositide 3-Kinase in T Lymphocytes -Coupledi Factor Activates a G The CXC Chemokine Stromal Cell-Derived (1999) (0)
- The inhibition of nitric oxide (NO) production in patients with colitis by anti-inflammatory cytokines and steroids is due to reduced transcription of iNOS (2000) (0)
- ACTIVATION OF PROTEIN KINASE C INHIBITS THROMBIN AND FLUORIDE STIMULATED EICOSANOID PRODUCTION IN HUMAN PLATELETS (1987) (0)
- myo‐Inositol 1,4,6‐Triphosphate: A New Synthetic Ca2+‐Mobilising Inositol Phosphate. (1994) (0)
- Synergistic II-8 Synthesis by Human Peritoneal Mesothelial Cells (Hpmc) Following II-1β and Tnfα Treatment (1993) (0)
- The chemokins biology of the inflammatory peptide supergene family II: Preface (1993) (0)
- CCR7 Deficiency Enhances Hematopoietic Stem Cell And Myeloid Progenitor Cell Proliferation And Ameliorates Susceptibility To Invasive Pulmonary Aspergillosis Following Hematopoietic Stem Cell Transplantation (2010) (0)
- Mast Cell Migration In Vitro and In Vivo The Role of the CCL2/CCR2 Axis in Mouse (2010) (0)
- Measurement of changes in the microvasculature A simple perfusion system for the study of histamine release from rat peritoneal mast cells (2006) (0)
- Pattern of chemokine secretion from stimulated human dermal fibroblasts: Analysis by electrospray mass spectrometry (1994) (0)
- Are mononuclear cells the site of action of steroids & “anti-inflammatory” cytokines in colitis? (1998) (0)
- Human Peritoneal Mesothelial Cells Synthesize I nterleukin-8 Synergistic Induction by Interleukin- 1 and Tumor Necrosis Factor-a-Nicholas (2007) (0)
- Chemotactic Cytokine Generation by Human Lung Microvascular Endothelial Cells: Differential Regulation by Gamma Interferon (1993) (0)
- Pharmacology Of 12-Deoxyphorbol Phenyl Acetate (12-DOPP) Induced Human Platelet Aggregation (1981) (0)
- Model of Pulmonary Invasive Aspergillosis Enhances Fungal Clearance in a Murine CCR 7 Deficiency on Dendritic Cells (2009) (0)
- Abstract 878: Targeted expansion of NKG2D-expressing tumor infiltrating leukocytes improves adoptive transfer immunotherapy (2020) (0)
- 842 – ENHANCEMENT OF IN VITRO HUMAN LYMPHOCYTE RESPONSES BY INHIBITORS OF ARACHIDONIC ACID METABOLISM; REVERSIBILITY BY PROSTAGLANDIN E2 AND PROSTACYCLIN (1978) (0)
- Elucidating Compound Selectivity: Integration of Chemoproteomic, Protein Signaling, and Gene Expression Profiles (2009) (0)
- Intrinsic Aerobic Capacity Influences Hypoxia-Induced Pulmonary Hypertension. (2009) (0)
- PLATELET ACTIVATING FACTOR (PAF) IN ODONTOGENIC CYSTS (1989) (0)
- Paradoxical effects of indomethacin and trifluoperazine on Ca2+ ionophore A23187-induced human platelet aggregation, thromboxane B2 production, and dense granule release. (1983) (0)
- Incidence Of Venous Thrombosis, Increased Platelet Release Reaction And Thromboxane Synthesis Following Tourniquet Ischaemia (1981) (0)
- INTERLEUKIN-1 INDUCED IL-8 GENERATION IN MESANGIAL CELLS INVOLVES A PERTUSSIS-TOXIN-SENSITIVE GUANINE-NUCLEOTIDE BINDING-COMPONENT (1992) (0)
- Thrombocytopaenia, Thromboxane And Prostacyclin Production During The Forssman Reaction In The Guinea-Pig: Effect Of A Thromboxane Synthetase Inhibitor (1981) (0)
- Oncogenic Ha-Ras-induced Signaling Activates NF- (cid:107) B Transcriptional Activity, Which Is Required for Cellular Transformation* (1997) (0)
- Phenotype of polarized M-CSF and GM-CSF MΦ. (2013) (0)
- Evaluation Of In Vivo Platelet Activation In Sickle Cell Disease (1981) (0)
- Abstract 3440: Novel in vitro TME platform for rapid cancer therapeutic and target discovery (2022) (0)
- Histologically normal colonic biopsies from patients with colitis behave like inflammed colon not bowel from healthy individuals: Steroid sensitivity of IL-8 & nitric oxide (NO) production* (1998) (0)
- The Effect of Haemofiltration on Circulating Cytokines in Children Undergoing Cardiopulmonary Bypass: A Preliminary Study (1993) (0)
- 1309 stimulates signal transduction through CCR8 (2001) (0)
- CHIRAL REGIOISOMERS OF INS(1,4,5)P-3 - STRUCTURE-ACTIVITY PROFILE (1995) (0)
- THE ROLE OF IONISED INTRACELLULAR FREE CALCIUM ([Ca++]i) IN THROMBIN-INDUCED DENSE GRANULE SECRETION (1987) (0)
- Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309 (2010) (0)
- Regulation of inflammatory mediator production in human colonic epithelial cells. (1997) (0)
- High-content analysis of signaling networks enables predictive compound profiling (2012) (0)
- Further characterisation of platelet-activating factor-induced IL1 production by human adherent monocytes (1987) (0)
- Calcium influx pathways in H EK 293 cells over-expressing trp3 channels (2001) (0)
- Endotoxin Induced Fall In Plasma Prekallikrein: Prevention By Prostacyclin And Lignocained (1981) (0)
- Abstract 3675: Novel immune oncology strategy for targeted cytotoxic lymphocyte activation (2017) (0)
- Characterisation of CXCR7, CXCR3 and aptypical on Mast Cells and other leukocytes (2007) (0)
- Evolutionarily Conserved Wnk and Ste20 Kinases Are Essential for Acute Volume Recovery and Survival after Kinase to Regulate P21waf1/cip1 Stability Mst Kinases Monitor Actin Cytoskeletal Integrity and Signal via C-jun N-terminal Kinase Stress-activated Small-molecule P21-activated Kinase Inhibitor P (2006) (0)
- Rhinovirus Induces IL-4, IL-5 And IL-13 In The Airways In Asthma But Not In Non-Atopic Subjects (2012) (0)
- Endothelin in the anaesthetised rabbit: action and interaction in the renal microcirculation. (1989) (0)
- Cytokine profiles in animal models of asthma (1993) (0)
- Differential regulation of RANTES production on primary human T-cells following combinations of CD3/CD28/PMA treatments (1997) (0)
- Role Of 5-HT In Susceptibility Of Rats With Low Intrinsic Aerobic Capacity To Hypoxia-Induced Pulmonary Hypertension (2011) (0)
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