J. William. Lown

J. William. Lown's AcademicInfluence.com Rankings

J. William. Lown

Chemistry

#2186

World Rank

#3058

Historical Rank

chemistry Degrees

J. William. Lown

Biology

#6217

World Rank

#8885

Historical Rank

Molecular Biology

#627

World Rank

#642

Historical Rank

Biochemistry

#778

World Rank

#882

Historical Rank

biology Degrees

Download Badge

Chemistry
Biology

J. William. Lown's Degrees

PhD Biochemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

Why Is J. William. Lown Influential?

(Suggest an Edit or Addition)

(See a Problem?)

J. William. Lown's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents. (1977) (259)
The mechanism of the bleomycin-induced cleavage of DNA. (1977) (229)
Synthetic DNA minor groove-binding drugs. (1999) (180)
Podophyllotoxins: current status and recent developments. (1998) (179)
HYPOCRELLINS and THEIR USE IN PHOTOSENSITIZATION * (1990) (179)
Anthracycline and anthracenedione-based anticancer agents (1988) (173)
The mechanism of the degradation of DNA by streptonigrin. (1976) (168)
Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay. (1976) (166)
Anthracycline and anthraquinone anticancer agents: current status and recent developments. (1993) (164)
Molecular recognition between oligopeptides and nucleic acids: novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity. (1986) (157)
Photosensitization by anticancer agents 12. Perylene quinonoid pigments, a novel type of singlet oxygen sensitizer (1992) (151)
Discovery and development of anthracycline antitumour antibiotics (1993) (139)
Phototherapeutic potential of alternative photosensitizers to porphyrins. (1994) (128)
Anticancer, Anti-inflammatory and Analgesic Activity Evaluation of Heterocyclic Compounds Synthesized by the Reaction of 4-Isothiocyanato-4-methylpentan-2-one with Substituted o-Phenylenediamines, o-Diaminopyridine and (Un)Substituted o (2001) (119)
Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids. (1985) (118)
Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects. (1982) (111)
Synthesis and sequence-specific DNA binding of a topoisomerase inhibitory analog of Hoechst 33258 designed for altered base and sequence recognition. (1992) (109)
Molecular recognition between oligopeptides and nucleic acids. Monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding. (1987) (106)
Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. (1993) (105)
Recent developments in sequence selective minor groove DNA effectors. (2000) (101)
Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping. (1978) (96)
Photosensitization with anticancer agents. 15. Perylenequinonoid pigments as potential photodynamic therapeutic agents: formation of semiquinone radicals and reactive oxygen species on illumination. (1993) (95)
Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents. (1979) (94)
Bis-benzimidazole anticancer agents: targeting human tumour helicases. (1999) (91)
Electrochemical Studies of Antitumor Antibiotics III . Daunorubicin and Adriamycin (1977) (88)
Effects of analogs of the DNA minor groove binder Hoechst 33258 on topoisomerase II and I mediated activities. (1992) (86)
Molecular mechanisms of binding and single-strand scission of DNA by the antitumor antibiotics saframycins A and C (1982) (85)
Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. (1997) (84)
High-field NMR and restrained molecular modeling studies on a DNA heteroduplex containing a modified apurinic abasic site in the form of covalently linked 9-aminoellipticine. (1994) (81)
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation. (1989) (77)
Mechanism of action of 2-haloethylnitrosoureas on DNA and its relation to their antileukemic properties (1978) (77)
Design and binding of a distamycin A analog to d(CGCAAGTTGGC).cntdot.d(GCCAACTTGCG): synthesis, NMR studies, and implications for the design of sequence-specific minor groove binding oligopeptides (1992) (70)
α-DNA I. Synthesis, characterization by high field 1H-NMR, and base-pairing properties of the unnatural hexadeoxyribonudeotide α-[d(CpCpTpTpCpC)] with its complement β-[d(GpGpApApGpG)] (1986) (69)
Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA (1976) (69)
Convenient Routes to Substituted Benzimidazoles and Imidazolo[4,5-b]pyridines Using Nitrobenzene as Oxidant (1990) (69)
Pyrroloquinoline and pyridoacridine alkaloids from marine sources. (1999) (68)
α-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural α-hexadeoxyribonucleotide α-[d(CpApTpGpCpG)] with its β-complement β-[d(GpTpApCpGpC)] deduced from high field 1H-NMR (1987) (67)
Molecular recognition between ligands and nucleic acids: novel pyridine- and benzoxazole-containing agents related to Hoechst 33258 that exhibit altered DNA sequence specificity deduced from footprinting analysis and spectroscopic studies. (1990) (66)
Efficient total syntheses of the oligopeptide antibiotics netropsin and distamycin (1985) (63)
THE CONFORMATIONS IN SOLUTION OF trans-CYCLOHEXENE DIHALIDES AND cis- AND trans-1,2-CYCLOHEXANEDIOLS AND DERIVATIVES (1964) (63)
Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy. (1984) (63)
Evidence for the generation of free hydroxyl radicals from certain quinone antitumor antibiotics upon reductive activation in solution (1981) (62)
Studies Related to Antitumor Antibiotics. Part VI. Correlation of Covalent Cross-linking of DNA by Bifunctional Aziridinoquinones with their Antineoplastic Activity (1975) (62)
High field 1H-NMR analysis of the 1:1 intercalation complex of the antitumor agent mitoxantrone and the DNA duplex [d(CpGpCpG)]. (1985) (61)
Molecular mechanisms of action of anticancer agents involving free radical intermediates (1985) (59)
Enzymatic oxidative activation and transformation of the antitumor agent mitoxantrone. (1988) (59)
Hypocrellins as photosensitizers for photodynamic therapy: a screening evaluation and pharmacokinetic study (1996) (58)
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase. (1998) (57)
Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments. (1994) (56)
Nitrosourea-induced DNA single-strand breaks. (1979) (53)
UPTAKE KINETICS AND INTRACELLULAR LOCALIZATION OF HYPOCRELLIN PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY: A CONFOCAL MICROSCOPY STUDY (1995) (52)
Design, biochemical pharmacology, electrochemistry and tumour biology of anti-tumour anthrapyrazoles. (1986) (50)
Newer approaches to the study of the mechanisms of action of antitumor antibiotics (1982) (49)
Synthesis of novel imidazole-containing DNA minor groove binding oligopeptides related to the antiviral antibiotic netropsin (1987) (48)
Photosensitization with anticancer agents 13. The production of singlet oxygen by halogenated and metal-ion-chelated perylenequinones (1992) (48)
Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].cntdot.poly[d(G-C)], and poly[d(A-T)].cntdot.poly[d(A-T)] (1986) (48)
The mechanism of action of quinone antibiotics (2004) (48)
A facile synthesis of staurosporine aglycone (1994) (47)
Redox activities of antitumor anthracyclines determined by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation. (1986) (46)
Studies related to antitumor antibiotics. Part VIII. Cleavage of DNA by streptonigrin analogues and the relationship to antineoplastic activity. (1976) (45)
DNA recognition by lexitropsins, minor groove binding agents (1994) (45)
Heterocyclic Compounds as Inflammation Inhibitors (2002) (45)
Structural and dynamic aspects of binding of a prototype lexitropsin to the decadeoxyribonucleotide d(CGCAATTGCG)2 deduced from high-resolution 1H NMR Studies. (1988) (44)
Horseradish peroxidase-catalyzed oxidation of mitoxantrone: spectrophotometric and electron paramagnetic resonance studies. (1986) (43)
Molecular mechanism of binding of pyrrolo(1,4)benzodiazepine antitumour agents to deoxyribonucleic acid--anthramycin and tomaymycin. (1979) (42)
Photoreaction of psoralen and other furocoumarins with nucleic acids (1978) (42)
NMR characterization of a heterocomplex formed by distamycin and its analog 2-ImD with d(CGCAAGTTGGC):d(GCCAACTTGCG) : preference for the 1:1:1 2-ImD:Dst:DNA complex over the 2:1 2-ImD:DNA and the 2:1 Dst:DNA complexes (1993) (42)
Polyazamacrocycles. V. Structure of Isomeric 3,5,7,7,10,12,14,14-Octamethyl-1,4,8,11-tetraazacyclotetradecanes (1989) (42)
Molecular recognition between oligopeptides and nucleic acids: influence of van der Waals contacts in determining the 3'-terminus of DNA sequences read by monocationic lexitropsins (1988) (42)
A New DNA Minor Groove Binding Motif: Cross-Linked Lexitropsins (1994) (41)
Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. (1991) (41)
1996 Hoffman–LaRoche Award Lecture Photochemistry and photobiology of perylenequinones (1997) (40)
Characteristics of the interaction of anthrapyrazole anticancer agents with deoxyribonucleic acids: structural requirements for DNA binding, intercalation, and photosensitization. (1988) (39)
Photosensitization with anticancer agents 14. Perylenequinonoid pigments as new potential photodynamic therapeutic agents: formation of tautomeric semiquinone radicals (1992) (38)
Electrochemical Studies of Antitumor Antibiotics II . Polarographic and Cyclic Voltammetric Studies of Mitomycin C (1977) (38)
Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models. (1986) (38)
Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin. (2000) (38)
Studies related to antitumor antibiotics (1977) (36)
Interaction of the peroxidase-derived metabolite of mitoxantrone with nucleic acids. Evidence for covalent binding of 14C-labeled drug. (1989) (36)
Minor‐groove binders are inhibitors of the catalytic activity of DNA gyrases (1993) (35)
Sequence specific molecular recognition by a monocationic lexitropsin of the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies. (1988) (35)
Synthesis of novel thiazole-containing DNA minor groove binding oligopeptides related to the antibiotic distamycin (1990) (35)
Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. (1988) (35)
Mechanism of action of (2-haloethyl)nitrosoureas on DNA: discrimination between alternative pathways of DNA base modification by 1,3-bis(2-fluoroethyl)-1-nitrosourea by using specific deuterium labeling and identification of reaction products by HPLC/tandem mass spectrometry (1990) (35)
DNA sequence specificity of antitumor agents. Oncogenes as possible targets for cancer therapy. (1988) (34)
Sequence specific molecular recognition and binding by a GC recognizing Hoechst 33258 analogue to the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies. (1990) (34)
Studies related to antitumor antibiotics. Part XIII. Reactivity of 2- and 3-indolylcarbinyl compounds as models for mitosane action (1978) (34)
THE β-D -CONFIGURATION OF THE RIBOSYL NICOTINAMIDE PORTION OF DIPHOSPHOPYRIDINE NUCLEOTIDE (1963) (34)
Photosensitization by anticancer agents 21: new perylene- and aminonaphthoquinones. (1996) (34)
Studies related to antitumor antibiotics. Part IX. Reactions of carzinophillin with DNA assayed by ethidium fluorescence. (1977) (33)
Electron paramagnetic resonance characterization and conformation of daunorubicin semiquinone intermediate implicated in anthracycline metabolism, cardiotoxicity, and anticancer action (1984) (32)
Synthesis, complete 1H assignments and conformations of the self-complementary hexadeoxyribonucleotide [d(CpGpApTpCpG)]2 and its fragments by high field NMR. (1984) (32)
Design and Synthesis of Novel Pyrrolo[2,1-c][1,4]benzodiazepine-Lexitropsin Conjugates. (1999) (32)
α-DNA-III. Characterization by high field 1H-NMR, anti-parallel self-recognition and conformation of the unnatural hexadeoxyribonucleotides α-(d(CpApTpGpCpG) and α-d(CpGpCpApTpG). αOligodeoxynucleotides as potential cellular probes for gene control (1987) (32)
Anti-HIV-I activity of linked lexitropsins. (1992) (32)
Studies on the effects of the antitumor agent camptothecin and derivatives on deoxyribonucleic acid. Mechanism of the scission of deoxyribonucleic acid by photoactivated camptothecin. (1980) (31)
Lexitropsins in antiviral drug development. (1992) (31)
Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-trans-methylcyclohexyl)-1-nitrosourea. (1981) (31)
Studies related to antitumor antibiotics. 28. Structure and function of the antitumor antibiotic carzinophillin A: the first natural intercalative bisalkylator (1982) (30)
Addition reactions of acetylenic esters with substituted thioureas (1967) (30)
Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin. (1986) (30)
High-field 1H and 31P NMR studies on the binding of the anticancer agent mitoxantrone to d[CpGpApTpCpG]2. (1986) (30)
Synthesis of specifically nitrogen-15- and carbon-13-labeled antitumor (2-haloethyl)nitrosoureas. The study of their conformations in solution by nitrogen-15 and carbon-13 nuclear magnetic resonance electronic control in their aqueous decomposition (1981) (29)
Reaction of Cyclopropenones with Heteroaromatic Nitrogen Compounds (1971) (29)
Molecular recognition between oligopeptides and nucleic acids: DNA sequence specificity and binding properties of thiazole-lexitropsins incorporating the concepts of base site acceptance and avoidance. (1990) (29)
Structure of a dicationic monoimidazole lexitropsin bound to DNA. (1995) (29)
Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates. (2005) (28)
Mode of action of saframycin antitumor antibiotics: sequence selectivities in the covalent binding of saframycins A and S to deoxyribonucleic acid. (1990) (28)
FTIR study of specific binding interactions between DNA minor groove binding ligands and polynucleotides. (1992) (27)
A simple high-yielding approach to perylenequinone from the novel one-step double coupling reaction of 1,2-naphtoquinone (1992) (27)
Molecular recognition between oligopeptides and nucleic acids: sequence-specific binding of the naturally occurring antibiotic (4S)-(+)-anthelvencin A and its (4R)-(-) enantiomer to deoxyribonucleic acids deduced from proton NMR, footprinting, and thermodynamic data (1989) (27)
Isohelicity and Strand Selectivity in the Minor Groove Binding of Chiral (1R,2R)- and (1S,2S)-Bis(netropsin)-1,2-cyclopropanedicarboxamide Ligands to Duplex DNA (1994) (27)
Studies related to antitumor antibiotics. Part XIV. Reactions of mitomycin B with DNA. (1978) (27)
Molecular recognition between oligopeptides and nucleic acids: DNA binding specificity of a series of bis netropsin analogues deduced from footprinting analysis. (1990) (27)
PHOTOSENSITIZATION OF ANTICANCER AGENTS‐8. ONE‐ELECTRON REDUCTION OF MITOXANTRONE: AN EPR AND SPECTROPHOTOMETRIC STUDY (1989) (26)
Total synthesis and absolute configuration of the antibiotic oligopeptide (4S)-(+)-anthelvencin A and its 4R-(-) enantiomer (1988) (26)
Photosensitization with anticancer agents. 18. Perylenequinonoid pigments as potential photodynamic therapeutic agents: preparation and photodynamic properties of amino-substituted hypocrellin derivatives. (1993) (26)
Synthesis of carbazomycin B (1993) (26)
Studies Relating to Aziridine Antitumor Antibiotics. Part II. 13C and 1H Nuclear Magnetic Resonance Spectra of Mitomycin C and Structurally Related Streptonigrin (1974) (25)
Sequence-selective DNA binding by linked bis-N-methylpyrrole dipeptides: an analysis by methidium propyl-EDTA (MPE) footprinting and force-field calculations (1991) (25)
Alkyldinitrogen species implicated in the carcinogenic, mutagenic, and anticancer activities of N-nitroso compounds: characterization by nitrogen-15 NMR of nitrogen-15-enriched compounds and analysis of DNA base situselectivity by ab initio calculations (1984) (25)
Rational recognition of nucleic acid sequences. (1999) (24)
Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)--polymade conjugates and 2,2'-PBD dimers. (2000) (24)
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro. (1997) (24)
Reactions of Carbonyl Ylides (1971) (24)
Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer. (1996) (24)
Reactions of the antitumor agent carminic acid and derivatives with DNA (1979) (24)
Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo [2,1][1,4] benzodiazepine-glycosylated pyrrole and imidazole polyamide conjugates. (2003) (24)
Photosensitization of human leukemic cells by anthracenedione antitumor agents. (1990) (24)
Electrochemical Studies of Antitumor Antibiotics IV . Electrochemical Studies of Daunomycinone Analogues (1978) (23)
Interactions of the glycopeptide antitumor antibiotics bleomycin and tallysomycin with deoxyribonucleic acid in vitro. (1980) (23)
Photosensitization with anticancer agents 19. EPR studies of photodynamic action of calphostin C: formation of semiquinone radical and activated oxygen on illumination with visible light. (1994) (23)
Variation of DNA sequence specificity of DNA-oligopeptide binding ligands related to netropsin: imidazole-containing lexitropsins. (1989) (23)
Effects of alkylation by dimethyl sulfate, nitrogen mustard, and mitomycin C on DNA structure as studied by the ethidium binding assay. (1976) (23)
Electrochemical Studies of Antitumor Antibiotics V . An Electrochemical Method of Measurement of the Binding of Doxorubicin and Daunorubicin Derivatives to DNA (1984) (23)
Synthesis of (4S)- and (4R)-methyl 2-amino-1-pyrroline-5-carboxylate and their application to the preparation of (4S)-(+)- and (4R)-(-)-dihydrokikumycin B (1987) (23)
The mechanism of the neocarzinostatin-induced cleavage of DNA. (1978) (23)
DNA sequence selectivities in the covalent bonding of antibiotic saframycins Mx1, Mx3, A, and S deduced from MPE.Fe(II) footprinting and exonuclease III stop assays. (1992) (22)
Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation. (2003) (22)
Photosensitization by anticancer agents. 11. Mechanisms of photosensitization of human leukemic cells by diaminoanthraquinones: singlet oxygen and radical reactions. (1992) (22)
Synthesis, annealing properties, fluorine-19 NMR characterization, and detection limits of a trifluorothymidine-labeled antisense oligodeoxyribonucleotide 21 mer' (1991) (22)
Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers. (2000) (22)
Molecular recognition between oligopeptides and nucleic acids: DNA binding selectivity of a series of 1,2,4-triazole-containing lexitropsins. (1991) (22)
ELECTROPHILIC ADDITIONS OF IODONIUM NITRATE TO UNSATURATED SUBSTRATES (1977) (22)
Photosensitization by antitumor agents 3: spectroscopic evidence for superoxide and hydroxyl radical production by anthrapyrazole-sensitized oxidation of NADH. (1986) (21)
Photosensitization with anticancer agents. 16. The photo-oxidation of hypocrellin A. A mechanism study using 18O labelling. (1993) (21)
CHARACTERIZATION OF A CPI-LEXITROPSIN CONJUGATE-OLIGONUCLEOTIDE COVALENT COMPLEX BY 1H NMR AND RESTRAINED MOLECULAR DYNAMICS SIMULATION (1995) (21)
Noval antitumor nitrosoureas and related compounds and their reactions with DNA. (1980) (21)
Subcellular distribution of a nitroxide spin-labeled netropsin in living KB cells. Electron paramagnetic resonance and sequence specificity studies. (1989) (21)
A general solution- and solid-phase synthetic procedure for incorporating three contiguous imidazole moieties into DNA sequence reading polyamides. (2001) (20)
SYNTHETIC CHEMISTRY OF NATURALLY OCCURRING OLIGOPEPTIDE ANTIBIOTICS AND RELATED LEXITROPSINS (1989) (20)
Design and development of sequence selective lexitropsin DNA minor groove binders (1995) (20)
Addition of Iodonium Nitrate to Unsaturated Hydrocarbons (1971) (20)
Structure of the adduct formed between 3-aminocarbazole and the apurinic site oligonucleotide model d[Tp(Ap)pT] (1987) (20)
Heterocyclic compounds as inflammation inhibitors. (2002) (20)
PHOTOSENSITIZATION BY ANTITUMOR AGENTS—1. PRODUCTION OF SINGLET OXYGEN DURING IRRADIATION OF ANTHRAPYRAZOLES WITH VISIBLE LIGHT (1986) (20)
Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: synthesis, inhibitory activity against topoisomerase I, and biological evaluation. (1996) (19)
Studies related to antitumor antibiotics. Part XXIV. High field 1H nmr analysis and conformations of saframycins A and C (1981) (19)
Bleomycin models. Haemin–acridines which bind to DNA and cause oxygen-dependent scission (1982) (19)
Two-dimensional double-quantum spectroscopy for the hydrogen NMR assignment of oligodeoxyribonucleotides (1984) (19)
148. Proton magnetic studies of rotenone and related compounds (1962) (19)
Molecular mechanisms of binding and single-strand scission of deoxyribonucleic acid by the antitumor antibiotics saframycins A and C. (1982) (19)
Design, synthesis, and sequence selective DNA cleavage of functional models of bleomycin. 1. Hybrids incorporating a simple offal-complexing moiety of bleomycin and lexitropsin carriers. (1995) (19)
DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity (2001) (19)
Formation of benzoxathiete under mild conditions and its valence tautomerism in solution to monothio-o-benzoquinone: an experimental and quantum chemical study (1989) (19)
Photosensitization by antitumor agents, 4. Anthrapyrazole-photosensitized formation of single strand-breaks in DNA. (1988) (19)
Photosensitization by antitumor agents--7. Correlation between anthracenedione-photosensitized DNA damage, NADH oxidation and oxygen consumption following visible light illumination. (2008) (19)
Thermally disallowed valence tautomerization of an indano[1,2-b]aziridine to an isoquinolinium imine (1971) (18)
Transannular cyclizations of 1,2-dithia-5,8-diazacyclodeca-4,8-dienes during borohydride reduction (1987) (18)
Ethidium binding assay for reactive oxygen species generated from reductively activated adriamycin (doxorubicin). (1984) (18)
Quantum chemical studies of the products of decomposition of anticancer (2-haloethyl)nitrosoureas under physiological conditions (1988) (18)
Structural and dynamic aspects of the sequence specific binding of netropsin and its bis-imidazole analogue on the decadeoxyribonucleotide d-[CGCAATTGCG]2. (1988) (18)
Reaction of 3-aroylaziridines with aryl isothiocyanates (1969) (18)
Structural and dynamic aspects of non-intercalative (1:1) binding of a thiazole-lexitropsin to the decadeoxyribonucleotide d-[CGCAATTGCG]2: An 1H-NMR and molecular modeling study. (1991) (18)
Stereochemistry and mechanism of the thermal [1,3] alkyl shift of stable 1,4-dialkyl-1,4-dihydropyrazines (1974) (18)
CC-1065 functional analogues possessing different electron-withdrawing substituents and leaving groups: synthesis, kinetics, and sequence specificity of reaction with DNA and biological evaluation. (1993) (18)
Molecular recognition and binding of a GC site-avoiding thiazole-lexitropsin to the decadeoxyribonucleotide d-[CGCAATTGCG]2: 1H-NMR evidence for thiazole intercalation. (1990) (18)
Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin. (2001) (18)
Synthesis and cycloaddition reactions of 2-(2-thienyl)aziridines (1970) (18)
Glycosidic coupling of regiospecifically synthesized xantho[2,3-g]tetralin aglycones to afford antileukemic but redox inactive structures related to anthracyclines (1985) (18)
Photosensitization by selected anticancer agents. (1990) (18)
PHOTOSENSITIZATION BY ANTICANCER AGENTS—10. ortho‐SEMIQUINONE AND SUPEROXIDE RADICALS PRODUCED DURING ANTHRAPYRAZOLE‐SENSITIZED OXIDATION OF CATECHOLS (1992) (18)
Structure and dynamics of ligand-template interactions of topoisomerase inhibitory analogs of Hoechst 33258: high field 1H-NMR and restrained molecular mechanics studies. (1992) (17)
The Chemistry of DNA Damage by Antitumour Drugs (1983) (17)
Discovery and Development of Anthracycline Antitumor Antibiotics (1993) (17)
Application of functionalised 1,3-dipoles to the synthesis of fused heterocycles (1975) (17)
Discrimination between alternative pathways of aqueous decomposition of antitumor (2-chloroethyl)nitrosoureas using specific oxygen-18 labeling (1982) (16)
Mode of DNA binding of bis-benzimidazoles and related structures studied by electric linear dichroism. (1994) (16)
Convenient syntheses of pyrroloiminoquinone and its lexitropsin-linked derivative (1994) (16)
Optimization of cross-linked lexitropsins. (1996) (16)
Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI--N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency. (1996) (16)
A Concise Synthesis of the Pyrroloquinoline Nucleus of the Makaluvamine Alkaloids (1997) (16)
Characterization of the reaction products of deoxyguanosine with the anticancer agent BFNU and BFNU-1,1,1',1'-d4 in different buffers by high-performance liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. (1990) (15)
Sequence specific molecular recognition and binding of a monocationic bis-imidazole lexitropsin to the decadeoxyribonucleotide d-[(GATCCGTATG).(CATACGGATC)]: structural and dynamic aspects of intermolecular exchange studied by 1H-NMR. (1988) (15)
Synthesis and biodistribution of 14C‐radiolabelled hypocrellin B (1995) (15)
Photosensitization by antitumor agents 2: anthrapyrazole-photosensitized oxidation of ascorbic acid and 3,4-dihydroxyphenylalanine. (1986) (15)
Electrochemical Studies of Antitumor Antibiotics: I . Cyclic Voltammetric Study of Mitomycin B (1977) (15)
Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the chemical reactions with deoxyribonucleic acid. (1979) (15)
Photosensitization by antitumor agents. 5. Daunorubicin-photosensitized oxidation of NAD(P)H in aqueous and N,N-dimethylformamide/aqueous solutions--an electron paramagnetic resonance study. (1988) (15)
Enediyne-lexitropsin DNA-targeted anticancer agents. Physicochemical and cytotoxic properties in human neoplastic cells in vitro, and intracellular distribution. (1997) (14)
1,3-Dipolar cycloaddition of nitrosonaphthols to 3-aroylazindines. Novel syntheses of substituted naphtho[1,2-d]oxazoles and naphtho[2,1-d]oxazoles (1970) (14)
Studies Relating to Aziridine Antitumor Antibiotics. Part I. Asymmetric Syntheses. Part II. Chiral Aziridines and their Conversion to α-Aminoacids (1973) (14)
Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules. (1992) (14)
Design of Sequence-specific Agents: Lexitropsins (1993) (14)
Reactions of Functionalized 1,3-Dipoles (1974) (14)
Reaction of Diphenylcyclopropenethione with Heteroaromatic Nitrogen Compounds (1971) (14)
Further Synthetic Applications of Functionalized 1,3-Dipoles (1975) (14)
SYNTHESIS AND BIOLOGICAL EVALUATION OF HYBRID MOLECULES CONTAINING THE PYRROLOQUINOLINE NUCLEUS AND DNA-MINOR GROOVE BINDERS (1996) (14)
Lexitropsins: rational design of DNA sequence reading agents as novel anti-cancer agents and potential cellular probes. (1988) (13)
Molecular Mechanisms of DNA Sequence Recognition by Groove Binding Ligands: Biochemical and Biological Consequences (1990) (13)
Orbital symmetry control in the thermal and photoinduced pericyclic reactions of some 1,2-dihydropyrazines with dimethyl acetylenedicarboxylate (1975) (13)
Lexitropsin Conjugates: Action on DNA Targets (1997) (13)
Formation of novel 1,2-oxathietanes from 2-chloroethyl sulfoxide precursors and their reactions in solution, including formal [.sigma.2s + .sigma.2a] cycloreversions and rearrangements (1986) (13)
Thermal Decomposition of Stereoisomeric 3-Aroyl- and 3-Carbomethoxyaziridines in Acetonitrile (1972) (13)
Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates. (2003) (13)
Bis-intercalative binding to DNA of novel bis(10-methyl)acridinium chlorides and its dependence on chain length of linker. (1978) (13)
Mechanism of action of antitumor 3-(2-haloethyl) aryltriazenes on deoxyribonucleic acid. (1982) (13)
Synthesis and redox properties of chromophore modified glycosides related to anthracyclines (1982) (13)
Structure and conformation of saframycin R determined by high field 1H and 13C NMR and its interactions with DNA in solution. (1983) (13)
Diphenylcyclopropenethione S-oxide (1970) (13)
Reaction of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) with guanosine: evidence for a new mechanism of DNA modification. (1986) (13)
Enzymatic oxidative activation of 5-iminodaunorubicin. Spectrophotometric and electron paramagnetic resonance studies. (1989) (13)
Reaction of Diphenylcyclopropenethione with Pyridinium Imines (1972) (13)
Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the intermediates from nitrosourea decomposition. (1979) (12)
Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins. (1999) (12)
Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis. (1990) (12)
Synthesis and DNA cleaving properties of hybrid molecules containing propargylic sulfones and minor groove binding lexitropsins (1993) (12)
Studies Related to Antitumor Antibiotics. Part III. Syntheses of 1,2,3,4,5,6-Hexahydro-2,3-benzazocin-5-ones as Possible Intermediates in the Biosynthesis of Mitomycins (1975) (12)
Reaction of 3-aroylaziridines with diphenylcyclopropenone. Synthesis and properties of novel 4-aroyl-4-oxazolines (1970) (12)
Reactions of Tetrasubstituted Azomethine Ylides Generated from Tetracyanoethylene Oxide (1972) (12)
Synthesis and reactions of deuterated 2-(alkylimino)-3-nitrosooxazolidines, 3-alkyl-1-(2-hydroxyethyl)-1-nitrosoureas, and related compounds as possible intermediates in the aqueous decomposition of 3-alkyl-1-(2-chloroethyl)-1-nitrosoureas (1981) (12)
DNA binding studies and influence on the activity of DNA topoisomerases of bis-netropsins: different effects of analogs containing cis and trans ethylene linkers. (1997) (12)
Synthesis of New Armed Cyclopolyamines and Their Selective Extraction Properties for Metal Ions (1995) (11)
Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriers (1993) (11)
Structure and conformation of the duplex consensus acceptor exon:intron junction d[(CpTpApCpApGpGpT). (ApCpCpTpGpTpApG)] deduced from high-field 1H-NMR of non-exchangeable and imino protons. (1986) (11)
Design, synthesis, DNA sequence preferential alkylation and biological evaluation of N-mustard derivatives of distamycin and netropsin analogues. (1995) (11)
The reaction of lead tetra-acetate with oximes. Part I. Alicyclic and aliphatic oximes (1966) (11)
An alternative method for synthesis of the CC-1065 pharmacophore, 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (1993) (11)
Photosensitization with anticancer agents. 20--EPR studies on the photodynamic action of phleichrome: formation of semiquinone radical and activated oxygen species on illumination with visible light. (1995) (11)
Synthesis of novel cross-linked bis-lexitropsins (1994) (11)
10-Acetyl-10-hydroxyxantho[2,3-f]tetralin 8-glycosides as angular chromophore analogues of anthracyclines: synthesis, redox properties, microsomal oxygen consumption, and antileukemic evaluation. (1986) (11)
Reactions of diphenylcyclopropenone with 1,3-dipoles (1970) (11)
Thermal [2 + 3] cycloaddition of imino compounds to 3-aroylaziridines. Synthesis of imidazolidines (1969) (11)
Synthesis of specifically deuterium labeled sulfur and oxygen ether side-chain-extended antileukemic (2-chloroethyl)nitrosoureas and study of their products and pathways of decomposition under physiological conditions (1982) (10)
Sequential valence tautomerism, 1,3-sigmatropic (C→N) alkyl shift and cycloreversion to pyrrole and ketenimine in the reaction of some 1,2-dihydropyrazines with dimethyl acetylene-dicarboxylate (1973) (10)
Benzoxathiete and related structures: experimental and quantum chemical studies (1990) (10)
1,3-Dipolar cycloaddition reactions of 2-(2′-thienyl)aziridines (1970) (10)
DNA minor groove binding of cross-linked lexitropsins: experimental conditions required to observe the covalently linked WPPW (groove wall-peptide-peptide-groove wall) motif. (1995) (10)
Stereoelectronic control in the aqueous decomposition of novel nitrosothioureas (1983) (10)
Regiospecific synthesis of redox inactive ring C modified aglycones related to anthracyclines. Application of photo-Fries rearrangement and novel nucleophile-catalyzed rearrangements leading to the xantho[2,3-g]tetralin and xantho[2,3-f]tetralin systems (1984) (10)
Design, synthesis and antitumor cytotoxicity of novel bis-benzimidazoles. (2000) (9)
Novel cyclopropylindole conjugates and dimers: synthesis and anti-cancer evaluation. (2001) (9)
A 1H-NMR study of the DNA binding characteristics of thioformyldistamycin, an amide isosteric lexitropsin. (1992) (9)
Quantum chemical and molecular mechanics studies on the binding of stereoisomers of the oligopeptide antibiotics amidinomycin and noformycin to the minor groove of B-DNA. (1993) (9)
Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].poly[d(G-C)], and poly[d(A-T)].poly[d(A-T)]. (1986) (9)
Design, synthesis, DNA sequence preferential alkylation and biological evaluation of N-mustard derivatives of Hoechst 33258 analogues. (1995) (9)
Developmnet of an efficient oligonucleotide derivatization protocol (1991) (9)
A New All-Season Passive Sampling System for Monitoring H2S in Air (2002) (9)
SYNTHESIS OF POTENTIAL DNA BISINTERCALATIVE AGENTS OF THE PHENANTHRIDINIUM CLASS (1979) (9)
1H-NMR assignments of the non-exchangeable protons of the consensus donor exon:intron junctioń d(CpApGpGpTpApApGpT). (1985) (9)
Synthesis and Antitumor Cytotoxicity Evaluation of Novel Thiazole‐Containing Glycosylated Polyamides (2003) (9)
A Convenient Synthesis of Cross-Linked Homodimeric BIS-Lexitropsins (1995) (9)
Acetylenic esters. Part III. Reactions of thiocarbonyl compounds with methyl propiolate, methyl methylpropiolate, and methyl phenylpropiolate (1968) (9)
The 1,3-dipolar addition of 2-aroyl-aziridines to 1-nitrosonaphth-2-ol: novel syntheses of substituted naphtho[1,2-d]oxazoles (1970) (9)
Site Selective Alkoxymethylation of Imidazo[4,5-b]pyridines: Structural Analysis by High Field NMR Methods (1993) (9)
Protein kinase C-α inhibitors; structure-activity relationships in bis-indole series (1995) (9)
Mechanisms of distamycin A/DAPI chromosome staining. I. Competition binding effects of nonintercalative DNA groove-binding agents in situ and in vitro. (1993) (9)
Studies on the effects of the antitumor agent camptothecin and derivatives on DNA. Camptothecin potentiated cleavage of DNA by bleomycin in vitro. (1981) (9)
DNA sequence recognition altered bis-benzimidazole minor-groove binders (1998) (9)
The oxidation of selenocystamine to 2-aminoethaneselenenic acid. (1966) (8)
Design of distamicin analogues to probe the physical origin of the antiparallel side by side oligopeptide binding motif in DNA minor groove recognition. (1996) (8)
SYNTHESIS OF NEW BIS-CROWN ETHERS THAT SHOW SPECIFIC METAL ION TRANSPORT PROPERTIES (1995) (8)
Sequential assignments in deoxyribonucleotide tetramers by 31P/1H two‐dimensional shift correlation NMR spectroscopy (1986) (8)
Hybrid molecules containing propargylic sulfones and DNA minor groove-binding lexitropsins: synthesis, sequence specificity of reaction with DNA and biological evaluation. (1994) (8)
1,3-Dipolar cycloaddition reactions of monocyclic aziridines with dimethyl 1-cyclobutene-1,2-dicarboxylate (1994) (8)
Enhanced DNA alkylation activities of Hoechst 33258 analogues designed for bioreductive activation. (1997) (8)
Synthesis, DNA binding, sequence preference and biological evaluation of minor groove-selective N1-alkoxyalkyl-bis-benzimidazoles. (1994) (8)
Design, synthesis and topoisomerase II inhibition activity of 4'-demethylepipodophyllotoxin-lexitropsin conjugates. (1996) (7)
Psoralen--lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease III stop assay, and mode of binding from electric linear dichroism. (1994) (7)
Suprafacial [1,3]-sigmatropic benzyl shift in 1,4-dibenzyl-1,4-dihydro-2,6-diphenylpyrazine (1973) (7)
1,3-Dipolar cycloadditions to an isoquinolinium imine obtained by thermally disallowed valence tautomerism of a 6-cyclohexylimino-1,1a,6,6a-tetrahydro-1a-phenylindeno[1,2-b]azirine (1970) (7)
Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates. (2002) (7)
Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides. (2002) (7)
Synthesis of a Series of Acodazole and Naphthothiophene-Deuterioporphyrins and Metalloporphyrins (1992) (7)
Synthesis of an unsymmetrical bis-lexitropsin-1,2,9,9a–tetrahydrocyclo- propa[c]benzo[e]indol-4-one (CBI) conjugate (1999) (7)
Design and synthesis of new thiazolated cross-linked DNA binding polyamides for altered sequence recognition (2002) (7)
Synthetic studies in novel hypocrellin B derivatives (1993) (7)
The binding of prototype lexitropsins to the minor groove of DNA: quantum chemical studies. (1991) (7)
Synthesis and Cellular Uptake of Fluorescently Labeled 1-Chloromethyl-5- Hydroxy-1, 2-Dihydro-3H-Benz [e] Indole (Seco-CBI)- Pyrrole Polyamide Conjugates (2004) (7)
Effects of bifunctional netropsin-related minor groove-binding ligands on mammalian type I DNA topoisomerase. (1997) (7)
Selective Cleavage of Benzoxazoles to o-Hydroxy-N-Substituted Anilines with Sodium Borohydride-Acetic Acid (1990) (7)
Self-condensation and rearrangement of N-alkylphenacylamines (1973) (7)
Reaction of 3-aroylaziridines with diphenylcyclopropenone and subsequent stereospecific 1,3-dipolar cycloaddition of the adducts with dimethyl 1-cyclobutene 1,2-dicarboxylate (1995) (7)
Molecular Recognition Between Oligopeptides and Nucleic Acids: Influence of van der Waals Contacts in Determining the 3′‐Terminus of DNA Sequences Read by Monocationic Lexitropsins. (1988) (7)
Synthesis of Bis-Lexitropsin-1,2,9,9a-tetrahydrocyclopropa[ c]benz[e]indole-4-one (CBI) Conjugates (1998) (7)
Molecular recognition between ligands and nucleic acids: DNA binding characteristics of analogues of Hoechst 33258 designed to exhibit altered base and sequence recognition. (1991) (7)
Design and Efficient Synthesis of Novel DNA Interstrand Cross-Linking Agents: C2-Linked Pyrrolo[2,1-c][1,4]benzodiazepine Dimers (1999) (7)
Structure and conformation of the branch core triribonucleotide containing 2'-5' and 3'-5' phosphodiester linkages (A 2'p5'G 3'p5'C) i solution, essential for yeast mRNA splicing, deduced from 1H-NMR. (1987) (7)
The chemistry of Δ4-oxazolines 1. Nucleophilic additions to form substituted furans (1969) (7)
Synthesis and antitumor cytotoxicity evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine imidazole containing polyamide conjugates. (2003) (7)
Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy (1994) (6)
The addition of azomethine ylids to diphenylcyclopropenone: synthesis of novel 4-oxazolines (1968) (6)
Synthesis of novel-N-nitrosothioureas and examination of their mechanisms of formation by high-field nitrogen-15 and carbon-13 nuclear magnetic resonance spectra of specifically labeled compounds (1983) (6)
Design and Synthesis of 1,2,9,9a-Tetrahydrocyclo propa[c]benz[e]indole-4-one (CBI) Dimers (1999) (6)
Novel linked antiviral and antitumor agents related to netropsin - 2: Synthesis and biological evaluation (1991) (6)
Podophyllotoxins: Current Status and Recent Developments (1998) (6)
Amide isosteres of lexitropsins: synthesis, DNA binding characteristics and sequence selectivity of thioformyldistamycin. (1991) (6)
Design, synthesis and sequence selective DNA cleavage of functional models of bleomycin--II. 1,2-trans-disubstituted cyclopropane units as novel linkers. (1995) (6)
Structure and conformation in solution of the parallel-stranded hybrid α-d(CGCAATTCGC)·β-d(GCGTTAAGCG) by high-resolution 2D NMR (1992) (6)
Interaction of bisantrene anti-cancer agents with DNA: footprinting, structural requirements for DNA unwinding, kinetics and mechanism of binding and correlation of structural and kinetic parameters with anti-cancer activity. (1989) (6)
Synthesis of Geometrically Constrained Unsymmetrical Bis(polyamides) Related to the Antiviral Distamycin (2000) (6)
ALICYCLIC KETYLS: I. ANGULAR DEPENDENCE OF HYPERFINE COUPLING AND CONFORMATIONAL MOBILITY OF CYCLOHEXANONE KETYLS (1965) (6)
Functional Models of the Antitumor Antibiotic Bleomycin (1995) (6)
Mechanism of interstrand cross-linking of DNA by anticancer 2-haloethylnitrosoureas. (1986) (6)
Studies on cooperative binding of an extended distamycin A analogue in the minor groove of DNA by NMR spectroscopy. (1996) (6)
DNA sequence-selective binding of head-to-tail linked bis-lexitropsins: relation of phasing to cytotoxic potency. (1993) (6)
A novel asymmetric synthesis of α-aminoacids from nitriles employing diisopinocampheylborane as a chiral agent (1972) (6)
Molecular recognition between oligopeptides and nucleic acids rational design of sequence specific dna binding agents (1988) (6)
The reaction of 2-aroylaziridines with aldehydes to form oxazolidines (1970) (6)
Synthesis of a Novel N-Methoxymethylpyrrole-containing DNA Minor Groove Binding Oligopeptide Related to Distamycin (1995) (5)
Design, synthesis and evaluation of novel bismustard cross-linked lexitropsins (1995) (5)
Reaction of 1-Nitroso-2-naphthylamine with 3-Aroylaziridines (1971) (5)
Structure and conformation of the duplex consensus 5'-splice site d[(CpApGpGpTpApApGpT).(ApCpTpTpApCpCpTpG)] deduced from high field 1H-NMR of the non-exchangeable and imino protons. (1987) (5)
Enzymatic preparation of optically active precursors of CPI, the DNA alkylation subunit of the naturally occurring antitumour antibiotic CC-1065 (1996) (5)
The reaction of 2-arenoylaziridines with aldehydes to form oxazolidines (1970) (5)
Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNA by Bleomycin (1979) (5)
Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Pathways of aqueous decomposition and pharmacological characteristics of new anticancer disulfide-linked nitrosoureas. (1985) (5)
QUINODIMETHANE CHEMISTRY: THE GENERATION AND TRAPPING OF QUINODIMETHANES FROM SUBSTITUTED AROMATIC HYDROCARBONS WITH HIGH-POTENTIAL QUINONES (1966) (5)
Reaction of 3-aroylaziridines with 2-nitroso-1-naphthol (1970) (5)
Efficient Synthesis of a Novel Perylenequinone and Its Dimethyl Ether Derivatives (1995) (5)
Formation of 1,2-oxathietanes and their formal [σ2s+ σ2a]cycloreversion during the stereoelectronically controlled aqueous decomposition of sulfoxide-substituted nitrosoureas (1983) (5)
Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: synthesis, DNA sequence specificity and biological evaluation. (1996) (5)
A PRACTICAL ROUTE TO OPTICALLY ACTIVE CBI, A POTENT ANALOG OF THE CC-1065 ALKYLATION SUBUNIT (1997) (5)
Complete 1H assignments of the non-exchangeable protons of the non self-complementary heptadeoxyribonucleotide d[(GTCGTCA).(TGACGAC)] and its component strands by high field NMR. (1985) (5)
Kinetics and energetics of the addition of iodonium nitrate to unsaturated systems (1977) (5)
Naphtho[2,1-b]thiophene-linked 1,2-dithia-5,8-diazacyclodecanes and imidazolidino[1,2-d]dithiazepines: synthesis, structure proof by x-ray diffraction analysis, and DNA binding properties (1988) (5)
Novel cycloaddition reactions with alkyl substituted nitrogen heterocycles (1970) (4)
Reaction of dicyanomethylides with 3-(3',3'-dimethyltriazene-1-yl)-pyridine-4-carboxylic acid. Unexpected preferential formation of pyrido[4,3-a]indolizines (1992) (4)
Synthesis and in vitro cytotoxicity studies of novel L-tryptophan-polyamide conjugates and L-tryptophan dimers linked with aliphatic chains and polyamides. (2004) (4)
Synthesis of 3(2-haloethyl)aryltriazenes and study of their reactions in aqueous solution (1981) (4)
Liblomycin-mediated DNA cleavage in human head and neck squamous carcinoma cells and purified DNA. (1990) (4)
DNA interaction of the imidazole-containing lexitropsin ImPy: titration viscometric study in comparison to netropsin. (1995) (4)
Models for bleomycin antitumour antibiotics: haeminacridines which bind to DNA, cause oxygen-dependent strand scission, and exhibit anticancer properties (1984) (4)
Synthesis of nitrosothioureas. 15N N.m.r. evidence for the formation of thionitrosyl compounds in the nitrosation of thioureas (1981) (4)
Stable 1,4-dialkyl-1,4-dihydropyrazines (1972) (4)
Quantum chemical studies employing an ab initio combination approach on the binding of the bis-benzimidazole Hoechst 33258 to the minor groove of DNA. (1995) (4)
SYNTHESIS OF NOVEL THIAZOLE-CONTAINING BIS-1-CHLOROMETHYL-5-HYDROXY-1,2-DIHYDRO-3H-BENZ[e]INDOLE(seco-CBI)-POLYAMIDE CONJUGATES AS ANTICANCER AGENTS (2002) (4)
Synthetic Application of Cycloaddition of Aziridines (1971) (4)
1H and 31P-NMR assignments of the non-exchangeable protons of the consensus acceptor exon:intron junction d(CpTpApCpApGpGpT). (1986) (4)
Thermal [2 + 3] cycloaddition of N-trichloroacetyldiphenylcyclopropenimine to 3-aroylaziridines and 3-carbomethoxyaziridines (1970) (4)
The conformations of the cis and trans-1,2-cyclohexanediols and certain of their derivatives (1963) (4)
SYNTHESIS OF AMIDINE AND BIS AMIDINE PERCURSORS (2001) (4)
A Simple High-Yielding Approach to Perylenequinone from the Novel One- Step Double Coupling Reaction of 1,2-Naphthoquinone. (1992) (4)
Conformations of the antitumor agent 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea in solution studied by 15N-NMR (1981) (4)
Erratum: Acetylenic esters. II. Further addition reactions with sulphur and nitrogen-containing compounds (1967) (4)
Quantum chemical studies of alkyldinitrogen species implicated in nitrosamine carcinogenesis (1989) (4)
NOVEL ANTITUMOR NITROSOUREAS AND RELATED COMPOUNDS AND THEIR REACTIONS WITH DNA (1980) (4)
A Convenient Synthesis of Substituted Oxazolo-[5,4-b]Pyridines Using Lead Tetraacetate as Oxidative Cyclizing Agent (1991) (4)
ALICYCLIC KETYLS: II. TEMPERATURE DEPENDENCE OF THE CONFORMATIONAL MOBILITY OF MEDIUM-SIZED RINGS (1965) (4)
Stereochemistry of [1,3]alkyl sigmatropic shift from nitrogen to carbon and its reverse in certain nitrogen heterocycles (1974) (4)
One-step synthesis of 3,5-dihydro-2H-pyrrolo[3,4-d]oxazoles by reaction of p-nitrosophenols with 2-aroylaziridines (1972) (4)
DNA Sequence Recognition of a Cross-Linked Polyamide: CD Studies, Footprinting and Effects on the Activity of DNA Gyrase (2000) (4)
558. Application of nuclear magnetic resonance spectroscopy to Diels–Alder adducts of p-benzoquinones (1963) (4)
Reactions of 4-aroyl-4-oxazolines and 3-aroyI-4,5-dihydrofurans (1970) (3)
Pyrroloquinoline and Pyridoacridine Alkaloids from Marine Sources (1999) (3)
Novel substituted 1,2-oxathietanes from competing cyclizations of 2-chloroethyl sulfoxide precursors. Observation of vinylogous 1,4-halogen participation in 1,2-oxathietane generation (1986) (3)
Novel Amination and 1,2-Amino,hydro-Elimination between 2,3-Diketopyrido[4,3,2-de]quinolines and Primary Amino Compounds (1999) (3)
SYNTHESIS OF THE PYRIDINO[4,3,2-de]QUINOLINE NUCLEUS: A DERIVATIVE OF THE DISCORHABDIN ALKALOIDS (1998) (3)
Reaction of iodonium nitrate with alkenes (1970) (3)
Synthesis and antitumor activity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents (1995) (3)
SYNTHESIS OF BIOREDUCTIVELY ACTIVATED ALKYLATING HOECHST 33258 ANALOGUES (1998) (3)
Peroxidase induced metabolism and lipid peroxide scavenging by antitumor agents. (1990) (3)
Synthesis of Designed Functional Models of Bleomycin Incorporating Imidazole - containing Lexitropsins as Novel DNA Recognition Sites (1995) (3)
The reaction of lead tetra-acetate with oximes. Part II. Substituted acetophenone oximes (1966) (3)
Principles and Methods in the Study of Free Radicals Generated in the Metabolism and Cytotoxic Action of Chemotherapeutic Agents (1988) (3)
Ab initio studies on 1,2-oxathietane, Z and E 3,4-dimethyl-1,2-oxathietane, and their products of formal [σ2s + σ2a] cycloreversion (1988) (3)
Dehydrogenation of 7,12-Dihydropleiadene Compounds with High Potential Quinones (1971) (3)
1996 Hoffman‐LaRoche Award Lecture Photochemistry and Photobiology of Perylenequinones (1997) (3)
Biophysical studies permitting an approach to a second generation of less cardiotoxic anthracyclines (1984) (3)
Synthesis of an Unsymmetrical Bis‐lexitropsin‐1,2,9,9a‐tetrahydrocyclopropa[c]benzo[e]indol‐4‐one (CBI) Conjugate. (1999) (3)
Quinodimethane Analogs in the Pleiadene and Acepleiadene Systems (1971) (3)
REACTION OF 3-AROYLAZIRIDINES WITH DIPHENYLCYCLOPROPENONE. 1,3-DIPOLE CASCADE FROM AZOMETHINE YLIDE TO CARBONYL YLIDE (1995) (3)
ANTITUMOR ANTIBIOTICS. VI. CORRELATION OF COVALENT CROSS-LINKING OF DNA BY BIFUNCTIONAL AZIRIDINOQUINONES WITH THEIR ANTINEOPLASTIC ACTIVITY (1976) (3)
RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A. (2001) (3)
Design and synthesis of DNA cleaving bleomycin models: 1,2-trans-disubstituted cyclopropane units as novel linkers (1994) (3)
Study of the conformation of novel N-nitrosothioureas by high-field nitrogen-15 and carbon-13 nuclear magnetic resonance spectroscopy employing specifically labeled compounds (1983) (3)
Solution structure studies of the cobalt complex of a bleomycin functional model bound to d(CGCAATTGCG)2 by two-dimensional nuclear magnetic resonance methods and restrained molecular dynamics simulation. (1996) (3)
Reaction of iodonium nitrate with some olefinic alcohols (1971) (3)
Practical Route to Introduce Lexitropsins Possessing A Natural Trisulfide Linker; Synthesis of N-(Lexitropsinthiosulfenyl) phthalimides (1998) (2)
SYNTHESIS OF HOECHST 33258 ANALOGUES DESIGNED TO TARGET HUMAN TUMOR HELICASES (1999) (2)
alpha-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural alpha-hexadeoxyribonucleotide alpha-[d(CpApTpGpCpG)] with its beta-complement beta-[d(GpTpApCpGpC)] deduced from high field 1H-NMR. (1987) (2)
Alicyclic Ketyls. III. Conformational Mobility of Cyclononanone Ketyl Examined by Electron Paramagnetic Resonance (1966) (2)
Synthesis and antitumor cytotoxicity evaluation of pyrido[4,3,2-de]quinolines and isoquinolino[6,5,4,3-cde]quinolines. (2000) (2)
Theoretical studies using an ab initio and molecular modelling combination method on the binding of sequence recognition altered bis-benzimidazoles to the minor groove of DNA. (1997) (2)
Synthesis and NMR characterization of selectively 15N‐labelled trans‐ and cis‐butenediamido‐linked bis‐netropsins (1995) (2)
Synthesis, determination of sequence selective DNA minor groove binding and biological evaluation of hybrid bithiazole-linked netropsin derivatives (1992) (2)
Reactive species from the electrocyclic opening of three-membered heterocycles (1973) (2)
Synthesis and separation of diastereomers of O-(2,2,2-trifluoroethyl)-3′,5′-dinucleoside phosphates (1994) (2)
Characterization of alkyldinitrogen species implicated in the carcinogenic, mutagenic and anticancer activities of N-nitroso compounds. (1984) (2)
Design and Synthesis of Sequence-specific DNA Minor Groove Recognizing Ligands of the Cross-linked Lexitropsin Class (1995) (2)
Electron paramagnetic resonance and spin trapping study of radicals formed during reaction of aromatic amines with isoamyl nitrite under aprotic conditions. (1990) (2)
Design and Synthesis of Novel Pyrrolo[2,1-c][1,4]benzodiazepine — Lexitropsin Conjugates. (1999) (2)
Synthesis of (4S)- and (4R)-Methyl 2-Amino-1-pyrroline-5-carboxylates and Their Application to the Preparation of (4S)-(+)- and (4R)-(-)-Dihydrokikumycin B. (1988) (2)
alpha-DNA-III. Characterization by high field 1H-NMR, anti-parallel self-recognition and conformation of the unnatural hexadeoxyribonucleotides alpha-[d(CpApTpGpCpG)] and alpha-[d(CpGpCpApTpG)]. Alpha-oligodeoxynucleotides as potential cellular probes for gene control. (1987) (2)
Section Review Oncologic, Endocrine & Metabolic: Bleomycin antibiotics and their role in cancer chemotherapy (1996) (2)
Design and Synthesis of Novel Pyrrolo[2,1-c][1,4]benzodiazepine - Imidazole Containing Polyamide Conjugates (2002) (2)
Shape-Selective Binding of Geometrically-Constrained bis-Distamycins to a DNA Duplex and a Model Okazaki Fragment of Identical Sequence (2000) (2)
DESIGN AND SYNTHESIS OF A NEW CLASS OF PYRROLOBENZIMIDAZOLE BASED AGENTS TO TARGET HUMAN TUMOR HELICASES (2000) (2)
Novel substituted indolocarbazoles as potent and selective inhibitors of protein kinase C (1995) (2)
Ab Initio Calculations on (-)-Calicheamicinone and Some of its Reactions Involved in its Activation and Interaction with DNA (2000) (2)
Design, Synthesis and in vitro Cytotoxicity Studies of Novel Pyrrolo[2,1][1,4]benzodiazepine‐glycosylated Pyrrole and Imidazole Polyamide Conjugates. (2004) (2)
Synthesis, topoisomerase I inhibitory activity and in vitro cytotoxicity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents. (1998) (2)
DNA Sequence Recognition of Thiazole-Containing Cross-Linked Polyamides Can Be Favored by T-A Steps (2002) (2)
Pathways and kinetics of aqueous decomposition and carbamoylating activity of new anticancer nitroimidazole-linked 2-chloroethylnitrosoureas. (1989) (2)
Solid-Phase Synthesis of 1-Chloromethyl-1,2-dihydro-3H-benz[e]indole (seco-CBI) and a Polyamide Conjugate (2000) (2)
731. Epimeric dihydroaromatic hydrocarbons: stereospecific syntheses of cis- and trans-1,2-dihydro-1,2-dimethylnaphthalenes and 9,10-dihydro-9,10-dimethylanthracenes (1962) (2)
Semi-Empirical, Ab Initio and Molecular Modeling Studies on the DNA Binding of a Calicheamicinone-Polyamide Conjugate (2000) (2)
Sequence dependent conformation and local geometry of the conserved branch site sequence element d(TpApCpTpApApC), essential for yeast mRNA splicing, deduced from high resolution 1H-NMR. (1987) (2)
High Resolution 2D-NMR Studies Including Complete Assignments and Conformational Characteristics of the NF-κB Binding Enhancer Element of HIV-LTR (1995) (2)
DNA Apurinic Sites: Synthesis of a Model Compound and Study of its Reactivity with 3-Aminocarbazole (1987) (1)
STEREOCHEMISTRY AND REGIOCHEMISTRY OF THE ADDITION OF IODONIUM NITRATE TO ALKENES (1974) (1)
Formation of Novel 1,2-Oxathietanes and Their Chemical Reactivity Including Formal [s2s+s2s] Cycloreversions and Rearrangement (1984) (1)
SYNTHESIS OF DESIGNED BLEOMYCIN MODELS WITH DIFFERENT DNA RECOGNITION SITES (1995) (1)
Conformational characteristics of high affinity Sp1 binding enhancer elements of HIV-LTR by high resolution 2D-NMR. (1995) (1)
Design and Synthesis of Novel Thiazole‐Containing Cross‐Linked Polyamides Related to the Antiviral Antibiotic Distamycin. (2000) (1)
Quantum Chemical Studies of Alkyldinitrogen Species Implicated in Nitrosamine Carcinogenesis. (1989) (1)
Total Synthesis and Absolute Configuration of the Antibiotic Oligopeptide (4S)-(+)-Anthelvencin A and Its 4R-(-) Enantiomer. (1988) (1)
Isolation and characterization of electrophiles from 2-haloethylnitrosoureas forming cytotoxic DNA cross-links and cyclic nucleotide adducts and the analysis of base site-selectivity by ab initio calculations. (1986) (1)
ELECTROPHILIC ADDITIONS OF BROMONIUM NITRATE TO UNSATURATED SUBSTRATES (1977) (1)
Reaction of 3,3-pentamethylenediaziridine with diphenylcyclopropenone (1969) (1)
SYNTHESIS OF A FURANO[4,3,2-de]QUINOLINE NUCLEUS: A DERIVATIVE OF THE DISCORHABDIN ALKALOIDS (1997) (1)
Synthtetic Studies on Mitomycins. An Alternative Synthesis of 2,3-Dihydro-1H and 9H-pyrrolo[1,2-a]indoles by Transannular Ring Closure (1976) (1)
Stereochemistry and regiochemistry of the addition of lodonium nitrate to alkenes (1973) (1)
Design and Synthesis of Cyclopropylpyrroloindole (CPI)— Lexitropsin Conjugates and Related Structures (2000) (1)
SNAr REACTIONS OF METHYL AND ETHYL 2-NITRO-5-FLUOROBENZOATES IN THE SYNTHESIS OF PYRRO[2,1-c][1.4]BENZODIAZEPINE PRECURSORS (1999) (1)
Design and Synthesis of Novel DNA Interstrand Cross-Linking Agents: C2-Linked Pyrrolo[2,1-c][1,4]benzodiazepine Polyamide Conjugates (2002) (1)
Synthesis of Analogs of Hoechst 33258 Designed for Altered Base and Sequence Recognition (2000) (1)
A Facile and Efficient Synthesis of Pyrrolo[2,l-c][l,4]benzodiazepine Antitumor Antibiotics: An Improved Deprotective Cyclization Method by "Clayon" (1998) (1)
Anti‐HIV‐I Activity of Linked Lexitropsins. (1992) (1)
Novel Cyclopropylindole Conjugates and Dimers: Synthesis and Anticancer Evaluation (2001) (1)
Ab Initio Studies of the Reaction of Hydrogen Transfer from DNA to the Calicheamicinone Diradical (2001) (1)
A Concise Synthesis of the Pyrroloquinoline Nucleus of the Makaluvamine Alkaloids. (1997) (1)
Structure‐Activity Relationship of Novel Oligopeptide Antiviral and Antitumor Agents Related to Netropsin and Distamycin. (1986) (1)
Molecular pharmacology of the anticancer agent mitoxantrone and related structures (1987) (1)
DNA alkylation by minor groove-binding N1-alkoxyalkyl-bis-benzimidazoles. (1995) (1)
Binding to DNA of selected lexitropsins and effects on prokaryotic topoisomerase activity. (1993) (1)
Solid-phase synthesis of a folate conjugate of a DNA binding polyamide (2002) (1)
Nucleophilic Displacement of Bromide by Thiosulfate Ion from 1,2-Aminobromopropanes (1965) (1)
DISCOVERY AND DEVELOPMENT OF ANTHRAQUINONE ANTITUMOUR ANTIBIOTICS (1993) (1)
Theoretical studies employing an ab initio and molecular modeling combination method on the DNA binding of bis-benzimidazoles designed for bioreductive activation. (1998) (1)
SYNTHESIS OF 3-(2-HALOETHYL)ARYLTRIAZENES AND STUDY OF THEIR REACTIONS IN AQUEOUS SOLUTION (1981) (1)
A Facile Synthesis of Staurosporine Aglycone. (1994) (1)
Interaction of the cobalt complex of a bleomycin functional model with d(CGCAATTGCG)2: evidence of minor groove binding by 2D NMR methods. (1995) (0)
Efficient Total Synthesis of the Oligopeptide Antibiotics Netropsin (I) and Distamycin (II). (1986) (0)
STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 1) (1996) (0)
1H-NMR Assignment of Single Strand and Duplex Splice Domain of the Consensus Donor Exon:Intron Junction (1985) (0)
10-Acetyl-10-hydroxyxantho(2,3-f)tetralin 8-Glycosides as Angular Chromophore Analogues of Anthracyclines: Synthesis, Redox Properties, Microsomal Oxygen Consumption, and Antileukemic Evaluation. (1987) (0)
Perylenequinonen for application as sonosensitizer (2002) (0)
STUDIES RELATED TO ANTITUMOR ANTIBIOTICS. PART VII. SYNTHESIS OF STREPTONIGRIN ANALOGS AND THEIR SINGLE STRAND SCISSION OF DNA (1976) (0)
STUDIES ON THE REACTIONS OF 2,3-DIKETOPYRIDO[4,3,2-de] QUINOLINES WITH ALIPHATIC AMINES (2001) (0)
A Convenient Synthesis of Substituted Oxazolo(5,4‐b)pyridines Using Lead Tetraacetate as Oxidative Cyclizing Agent. (1991) (0)
Novel Substituted 1,2-Oxathietanes from Competing Cyclizations of 2-Chloroethyl Sulfoxide Precursors. Observation of Vinylogous 1,4-Halogen Participation in 1,2-Oxathietane Generation. (1986) (0)
Naphtho(2,1-b)thiophene-Linked 1,2-Dithia-5,8-diazacyclodecanes and Imidazolidino(1,2-d)dithiazepines: Synthesis, Structure Proof by X-Ray Diffraction Analysis, and DNA Binding Properties. (1989) (0)
Two-Dimensional 1H-N.M.R. Assignment of Short Duplex Oligodeoxyribo-Nucleotides Which May Be Used as Potential Targets for Anticancer Drugs (1985) (0)
SEQUENTIAL VALENCE TAUTOMERISM, 1,3-SIGMATROPIC (C-N) ALKYL SHIFT AND CYCLOREVERSION TO PYRROLE AND KETENIMINE IN THE REACTION OF SOME 1,2-DIHYDROPYRAZINES WITH DIMETHYL ACETYLENEDICARBOXYLATE (1973) (0)
SYNTHESIS OF NITROSOTHIOUREAS. NITROGEN-15 NMR EVIDENCE FOR THE FORMATION OF THIONITROSYL COMPOUNDS IN THE NITROSATION OF THIOUREAS (1981) (0)
Convenient Routes to Substituted Benzimidazoles and Imidazolo(4,5-b)pyridines Using Nitrobenzene as Oxidant. (1990) (0)
Design, Synthesis and Evaluation of Novel Bismustard Cross-Linked Lexitropsis. (1996) (0)
Site Selective Alkoxymethylation of Imidazo(4,5-b)pyridines: Structural Analysis by High Field NMR Methods. (1993) (0)
Structure of the Adduct Formed between 3-Aminocarbazole and the Apurinic Site Oligonucleotide Model d(Tp(Ap)pT). (1988) (0)
THERMISCHE (2+3)-CYCLOADDITION VON IMINOVERBINDUNGEN AN 3-AROYL-AZIRIDINEN, SYNTH. VON IMIDAZOLIDINEN (1970) (0)
Convenient Synthesis of Cross‐Linked Homodimeric Bis‐lexitropsins (1995) (0)
Synthesis and in Vitro Anticancer Evaluation of (S)-2-Amino-3-(3-indolyl)propionic acid (L-Tryptophan) Pyrrole & Imidazole Polyamide Conjugates (2003) (0)
Reaction of 3‐Aroylaziridines with Diphenylcyclopropenone. 1,3‐Dipole Cascade from Azomethine Ylide to Carbonyl Ylide. (1995) (0)
Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-Polyaminoalkyl Conjugates by the Use of SNAr Reaction of 2-Nitro-5-fluorobenzoate Precursor as Key Reaction (2004) (0)
Synthesis of Carbazomycin B (I). (1993) (0)
ALKYLDINITROGEN SPECIES IMPLICATED IN THE CARCINOGENIC, MUTAGENIC, AND ANTICANCER ACTIVITIES OF N-NITROSO COMPOUNDS: CHARACTERIZATION BY NITROGEN-15 NMR OF NITROGEN-15-ENRICHED COMPOUNDS AND ANALYSIS OF DNA BASE SITUSELECTIVITY BY AB (1985) (0)
Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR. (1992) (0)
Selective Cleavage of Benzoxazoles (I) to o-Hydroxy N-Substituted Anilines (II) with Sodium Borohydride/Acetic Acid. (1990) (0)
Synthesis of Designed Functional Models of Bleomycin Incorporating Imidazole-Containing Lexitropsins as Novel DNA Recognition Sites. (1995) (0)
DNA sequence recognition in crosslinked polyamides: The head group and linker lengti affinity and specificity (2016) (0)
Transannular Cyclizations of 1,2-Dithia-5,8-diazacyclodeca-4,8-dienes During Borohydride Reduction. (1987) (0)
Benzoxathiete and Related Structures: Experimental and Quantum Chemical Studies. (1991) (0)
Synthesis of Analogues of Hoechst 33258 Designed for Altered Base and Sequence Recognition. (2000) (0)
SYNTHESIS OF SPECIFICALLY NITROGEN-15- AND CARBON-13-LABELED ANTITUMOR (2-HALOETHYL)NITROSOUREAS. THE STUDY OF THEIR CONFORMATIONS IN SOLUTION BY NITROGEN-15 AND CARBON-13 NUCLEAR MAGNETIC RESONANCE ELECTRONIC CONTROL IN THEIR AQUEOUS (1982) (0)
An Alternative Approach for Synthesis of the CC-1065 Pharmacophore, 1, 2,7,7a-Tetrahydrocycloprop(1,2-c)indol-4-one (I). (2010) (0)
STUDIES RELATED TO ANTITUMOR ANTIBIOTICS PART 3, SYNTHESES OF 1,2,3,4,5,6-HEXAHYDRO-2,3-BENZAZOCIN-5-ONES AS POSSIBLE INTERMEDIATES IN THE BIOSYNTHESIS OF MITOMYCINS (1975) (0)
GLYCOSIDIC COUPLING OF REGIOSPECIFICALLY SYNTHESIZED XANTHO(2,3-G)TETRALIN AGLYCONES TO AFFORD ANTILEUKEMIC BUT REDOX INACTIVE STRUCTURES RELATED TO ANTHRACYCLINES (1985) (0)
STEREOCHEMISTRY OF (1,3)ALKYL SIGMATROPIC SHIFT FROM NITROGEN TO CARBON AND ITS REVERSE IN CERTAIN NITROGEN HETEROCYCLES (1974) (0)
Convenient Syntheses of Pyrroloiminoquinone and Its Lexitropsin‐Linked Derivative. (1994) (0)
Erratum: Addition reactions of acetylenic esters with substituted thioureas (1967) (0)
CYCLOADDITIONSRK. MIT ALKYL-SUBSTITUIERTEN STICKSTOFFHETEROCYCLEN (1970) (0)
Quantum Chemical Studies of the Products of Decomposition of Anticancer (2-Haloethyl)nitrosoureas Under Physiological Conditions. (1988) (0)
1,3-DIPOLARE CYCLOADDITION VON NITROSONAPHTHOLEN AN 3-AROYL-AZIRIDINE, SYNTH. SUBSTITUIERTER NAPHTHO(1,2-D)OXAZOLE UND NAPHTHO(2,1-D)OXAZOLE (1970) (0)
Efficient Synthesis of a Novel Perylenequinone and Its Dimethyl Ether Derivatives. (1995) (0)
REACTIONS OF 1H-2,3-DIKETOPYRIDO[4,3,2-de] QUINOLINE WITH ACETONE AND ACETOPHENONE: A NOVEL SYNTHESIS OF THE ISOQUINOLINO[6,5,4,3-cde]QUINOLINE NUCLEUS (1998) (0)
STUDIES ON THE REACTIONS OF 2,3-DIKETOPYRIDO[4,3,2-de] QUINOLINES WITH AMINO ACIDS AND AMINO ESTERS (2000) (0)
Synthesis of a Novel N‐Methoxymethylpyrrole Containing DNA Minor Groove Binding Oligopeptide Related to Distamycin. (1995) (0)
STABILE 1,4-DIALKYL-1,4-DIHYDROPYRAZINE (1972) (0)
alpha-DNA. I. Synthesis, characterization by high field 1H-NMR, and base-pairing properties of the unnatural hexadeoxyribonucleotide alpha-[d(CpCpTpTpCpC)] with its complement beta-[d(GpGpApApGpG)]. (1986) (0)
1,3-DIPOLARE ADDITION VON 2-AROYLAZIRIDINEN AN 1-NITROSONAPHTHOL-(2), SYNTH. VON NAPHTHO(1,2-D)OXAZOLEN (1970) (0)
Synthesis of Polyaminoalkyl Substituted Conjugates of Pyrrolo[2,1-c][1,4]benzodiazepine Involving SNAr Reaction of 2-Nitro-5-fluorobenzoate Precursors (2000) (0)
Chapter 6 Unimolecular Homogeneous Decompositions and Isomerizations of Sulfur Compounds (1972) (0)
Synthesis and Separation of Diastereomers of O-(2,2,2-Trifluoroethyl)- 3′,5′-dinucleoside Phosphates. (1995) (0)
STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 2) (1996) (0)
Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides (2005) (0)
Enzymatic Preparation of Optically Active Precursors of CPI, the DNA Alkylation Subunit of the Naturally Occurring Antitumor Antibiotic CC‐ 1065. (1996) (0)
Agents antiretroviraux oligopeptidiques (1992) (0)
Molecular recognition of DNA binding agents: high-field 1H and 31P one- and two-dimensional NMR studies on the 1:1 intercalation complexes of mitoxantrone with selected oligodeoxyribonucleotides. (1986) (0)
Formation of Benzoxathiete Under Mild Conditions and Its Valence Tautomerism in Solution to Monothio-o-benzoquinone: An Experimental and Quantum Chemical Study. (1989) (0)
Synthesis of Novel Imidazole-Containing DNA Minor Groove Binding Oligopeptides Related to the Antiviral Antibiotic Netropsin. (1988) (0)
Molecular Recognition Between Oligopeptides and Nucleic Acids: Sequence-Specific Binding of the Naturally Occurring Antibiotic (4S)-(+)-Anthelvencin A and Its (4R)-(-) Enantiomer to Deoxyribonucleic Acids Deduced from 1H NMR, Footprin (1989) (0)
THERMISCHE (2+3)CYCLOADDITION VON N-TRICHLORACETYL-DIPHENYLCYCLOPROPENIMIN AN 3-AROYL- UND 3-CARBOMETHOXY-AZIRIDINE (1970) (0)
Formation of Novel 1,2-Oxathietanes from 2-Chloroethyl Sulfoxide Precursors and Their Reactions in Solution, Including Formal [σ2s + σ2a] Cycloreversions and Rearrangements. (1986) (0)
Reaction of 3-Aroylaziridines with Diphenylcyclopropenone and Subsequent Stereospecific 1,3-Dipolar Cycloaddition of the Adducts with Dimethyl 1-Cyclobutene 1,2-Dicarboxylate. (1995) (0)
STUDIES RELATING TO AZIRIDINE ANTITUMOR ANTIBIOTICS PART 2, (13)C AND (1)H NUCLEAR MAGNETIC RESONANCE SPECTRA OF MITOMYCIN C AND STRUCTURALLY RELATED STREPTONIGRIN (1974) (0)
High resolution 2D-NMR studies indicating complete assignments and conformational characteristics of the NF-kappa B binding enhancer element of HIV-LTR. (1995) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With J. William. Lown?

J. William. Lown is affiliated with the following schools:

University of Alberta

J. William. Lown's Academic­Influence.com Rankings

J. William. Lown's Degrees

Why Is J. William. Lown Influential?

J. William. Lown's Published Works

Published Works

What Schools Are Affiliated With J. William. Lown?

J. William. Lown's AcademicInfluence.com Rankings