Jack D. Keene | Academic Influence

Jack D. Keene's AcademicInfluence.com Rankings

Jack D. Keene

Biology

#8298

World Rank

#11351

Historical Rank

#2313

USA Rank

Microbiology

#478

World Rank

#539

Historical Rank

#119

USA Rank

Molecular Biology

#1307

World Rank

#1334

Historical Rank

#207

USA Rank

biology Degrees

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Biology

Jack D. Keene's Degrees

PhD Molecular Genetics Stanford University
Masters Microbiology Stanford University
Bachelors Biology University of California, Berkeley

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Why Is Jack D. Keene Influential?

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According to Wikipedia, Jack D. Keene is a James B. Duke Professor of Molecular Genetics and Microbiology at Duke University. Keene studies the regulation of RNA and the mechanisms of RNA-protein interactions. He identified RNA recognition motif proteins, which are the largest family of RNA-binding proteins. He isolated the first human autoimmune antigen. He formalized the posttranscriptional operon and regulon model to describe global gene regulation, and proposed the RNA regulon hypothesis to better understand post-transcriptional regulation of mRNAs encoding proteins. Keene introduced the RIP protocol for isolating specific mRNPs, which has become a tool for the mapping of mRNA targets of specific RBPs.

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Jack D. Keene's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

RNA regulons: coordination of post-transcriptional events (2007) (1267)
Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome (2001) (1102)
RNA recognition: towards identifying determinants of specificity. (1991) (656)
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. (2011) (613)
RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts (2006) (594)
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate (1993) (502)
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein (1989) (490)
Eukaryotic mRNPs may represent posttranscriptional operons. (2002) (477)
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation (2003) (449)
Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. (2000) (433)
Proteomic and immunologic analyses of brain tumor exosomes (2009) (385)
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. (2002) (383)
Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. (1993) (382)
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data (2011) (332)
Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays. (2002) (315)
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. (1999) (306)
The origins of defective interfering particles of the negative-strand RNA viruses (1981) (302)
A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30 gag antigen (1987) (276)
ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. (1999) (258)
Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. (1997) (247)
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome (2001) (243)
Molecular analysis of the 60-kDa human Ro ribonucleoprotein. (1988) (242)
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. (1998) (240)
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. (1999) (218)
Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes (1997) (210)
Genomic structure and amino acid sequence domains of the human La autoantigen. (1988) (185)
SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells (2016) (178)
The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies (1983) (175)
Inhibition of Polyglutamine Protein Aggregation and Cell Death by Novel Peptides Identified by Phage Display Screening* (2000) (172)
Ribonomic Analysis of Human Pum1 Reveals cis-trans Conservation across Species despite Evolution of Diverse mRNA Target Sets (2008) (170)
Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation. (2000) (168)
Search for organising principles: understanding in systems biology. (2004) (162)
RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. (1991) (157)
Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III (1994) (154)
Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites (1991) (153)
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. (2003) (153)
Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. (1994) (151)
Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus. (1998) (139)
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. (2008) (139)
Post-transcriptional operons and regulons co-ordinating gene expression (2005) (138)
Mechanisms coordinating ELAV/Hu mRNA regulons. (2013) (132)
U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts. (1991) (130)
Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. (1996) (128)
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis (2008) (124)
Systematic analysis of posttranscriptional gene expression (2010) (120)
Isolation and analysis of cDNA clones expressing human lupus La antigen. (1985) (120)
Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. (2003) (120)
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype (2008) (115)
Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs (2014) (112)
Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. (1990) (112)
The ribonome: a dominant force in co‐ordinating gene expression (2009) (108)
Site on the vesicular stomatitis virus genome specifying polyadenylation and the end of the L gene mRNA (1980) (107)
Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation (2011) (99)
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA (1994) (99)
Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene. (1981) (96)
Minireview: global regulation and dynamics of ribonucleic Acid. (2010) (95)
Coordinated posttranscriptional mRNA population dynamics during T-cell activation (2009) (94)
Post-transcriptional RNA regulons affecting cell cycle and proliferation. (2014) (91)
Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR1 (2009) (88)
Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. (2005) (86)
Nucleotide sequence and host La protein interactions of rabies virus leader RNA (1984) (86)
In vitro RNA selection identifies RNA ligands that specifically bind to eukaryotic translation initiation factor 4B: the role of the RNA remotif. (1996) (84)
Polycistronic vesicular stomatitis virus RNA transcripts. (1980) (82)
A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus. (1983) (81)
Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein (1991) (79)
Nucleotide sequence homology at the 3' termini of RNA from vesicular stomatitis virus and its defective interfering particles. (1978) (78)
Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins. (1994) (72)
XRN1 Stalling in the 5’ UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability (2015) (70)
In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. (1992) (69)
The complete sequence of a unique rna species synthesized by a DI particle of VSV (1978) (65)
Rapid and transient localization of the leader RNA of vesicular stomatitis virus in the nuclei of infected cells. (1982) (65)
Association between the 7 S RNA and the lupus La protein varies among cell types. (1983) (64)
Exploring molecular diversity with combinatorial shape libraries. (1994) (63)
Nuclear RNA-binding proteins. (1991) (63)
A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component (1989) (62)
A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody. (1988) (61)
Terminal sequences of vesicular stomatitis virus RNA are both complementary and conserved (1979) (56)
RNA sequence and transcriptional properties of the 3' end of the Newcastle disease virus genome. (1985) (54)
Activity‐dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain (2008) (54)
Autoantibodies specific for U1 RNA and initiator methionine tRNA. (1986) (53)
Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons (2008) (52)
Gene expression analysis of messenger RNP complexes. (2004) (51)
Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins. (1988) (50)
Intervening sequence between the leader region and the nucleopcapsid gene of vesicular stomatitis virus RNA (1980) (49)
A specific internal RNA polymerase recognition site of VSV RNA is involved in the generation of DI particles (1979) (49)
Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. (1985) (48)
Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq (2017) (47)
The U1 RNA-Binding Site of the U1 Small Nuclear Ribonucleoprotein (snRNP)-Associated A Protein Suggests a Similarity with U2 snRNPs (1989) (46)
Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions (1991) (45)
The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain (1994) (45)
RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus (1982) (43)
Vesicular stomatitis virus defective interfering particle containing a muted internal leader RNA gene. (1981) (41)
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA (1994) (41)
RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells (2004) (41)
Biological clocks and the coordination theory of RNA operons and regulons. (2007) (40)
Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3. (1980) (40)
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. (2011) (40)
Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs (1984) (38)
In vitro selection of RNA epitopes using autoimmune patient serum. (1993) (37)
RNA regulons in cancer and inflammation. (2018) (36)
La gets its wings (2004) (35)
Ribotrap : targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs. (2008) (35)
Temporal correlation of antibody responses to different epitopes of the human La autoantigen. (1990) (34)
60-kDa Ro protein autoepitopes identified using recombinant polypeptides. (1994) (34)
Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity (1996) (34)
Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus (1987) (34)
RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. (1992) (34)
Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. (1995) (33)
RNA surfaces as functional mimetics of proteins. (1996) (32)
Organizing mRNA export (2003) (31)
Biotinylated tags for recovery and characterization of ribonucleoprotein complexes. (2004) (31)
Antigenicity of a recombinant Ro (SS-A) fusion protein. (1990) (30)
Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen. (1988) (30)
The sequence at the termini of four genes of the three reovirus serotypes. (1982) (29)
In vitro synthesis of messenger RNA by a defective interfering particle of vesicular stomatitis virus. (1977) (29)
The plus strand of reovirus gene S2 is identical with its in vitro transcript. (1980) (29)
Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation (2015) (28)
Genome-wide regulatory analysis using en masse nuclear run-ons emRUNs and ribonomic profiling with autoimmune sera (2003) (28)
Tissue Type-Specific Expression of the dsRNA-Binding Protein 76 and Genome-Wide Elucidation of Its Target mRNAs (2010) (27)
Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus. (1986) (26)
Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus. (1983) (25)
Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. (1990) (25)
A Two-Phase Innate Host Response to Alphavirus Infection Identified by mRNP-Tagging In Vivo (2007) (24)
The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming (2018) (24)
Transcriptional and Posttranscriptional Regulation of Cytokine Gene Expression in HIV-1 Antigen-Specific CD8+ T Cells That Mediate Virus Inhibition (2014) (23)
Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera. (2003) (22)
The global dynamics of RNA stability orchestrates responses to cellular activation (2010) (21)
Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells. (1985) (21)
Molecular biology of nuclear autoantigens. (1992) (20)
Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. (1995) (20)
Characterization of the 3' terminus of RNA isolated from vesicular stomatitis virus and from its defective interfering particles. (1977) (19)
Association of 3' terminal RNA sequences with avian leukosis viruses causing a high incidence of osteopetrosis. (1982) (19)
Alu RNA-protein complexes formed in vitro react with a novel lupus autoantibody. (1985) (19)
Posttranscriptional generation of macromolecular complexes. (2003) (18)
The metabolic fate of independently initiated VSV mRNA transcripts. (1982) (18)
The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen. (1990) (18)
Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. (1991) (17)
Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein. (1984) (16)
DO-RIP-seq to quantify RNA binding sites transcriptome-wide. (2017) (14)
In vitro selection of aptamers from RNA libraries. (1999) (14)
Autoimmune epitopes in messenger RNA. (2002) (11)
Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins (1989) (11)
Coordinating Expression of RNA Binding Proteins with Their mRNA Targets (2014) (10)
Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. (1996) (9)
Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics. (1989) (9)
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells† (2021) (9)
RNA recognition by autoantigens and autoantibodies (2004) (8)
The globalization of messenger RNA regulation. (2014) (8)
Ras Post-transcriptionally Enhances a Pre-malignantly Primed EMT to Promote Invasion (2018) (8)
RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts (2018) (8)
A comparison of the extents of methylation of vesicular stomatitis virus messenger RNA. (1976) (8)
Erratum: Direct interactions between autoantigen La and human immunodeficiency virus leader RNA (Journal of Virology 68:11 (7014)) (1995) (8)
Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. (1985) (7)
Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome. (1989) (6)
Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis. (1989) (6)
HypothesisEukaryotic mRNPs May Represent Posttranscriptional Operons (2002) (5)
Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression. (1985) (5)
EFFECTS OF CELL EXTRACTS ON TRANSCRIPTION BY VIRION AND INTRACELLULAR NUCLEOCAPSIDS OF VESICULAR STOMATITIS VIRUS (1984) (5)
Phage Display Libraries (2002) (5)
Identification of specific protein-RNA target sites using libraries of natural sequences. (1999) (5)
Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis. (2017) (5)
Transfer RNAs associated with vesicular stomatitis virus. (1981) (4)
the endoplasmic reticulum Signal sequence-and translation-independent mRNA localization to (2)
Interactions of Proteins with Specific Sequences in RNA (1997) (2)
Leucine Periodicity of U2 snRNP Autoantigen A′ Implicated in U2 snRNP Protein: Protein Interactions (1989) (2)
Epitope Mapping of the Ro-RNP Autoantigen Using Recombinant Polypeptides (1989) (1)
Combinatorial chemistry (1998) (1)
Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs (1993) (1)
on membrane-bound ribosomes Partitioning and translation of mRNAs encoding soluble proteins (2003) (1)
A three allele TaqI polymorphism at TOP1 gene. (1990) (1)
Nature of the la and ro RNPs (1987) (1)
Molecular Features of an RNA Recognition Motif Family of Proteins (1989) (1)
TERMINAL SEQUENCE HOMOLOGIES IN REOVIRUS GENES (1980) (1)
Association between autoimmune epitopes and RNA binding domains of the human Lupus La protein (1987) (1)
Analysis of the 60 kD Ro Protein — hY RNA Complex: An RNA Recognition Motif Within Ro Protein is Required for Binding to hY 1 RNA (1989) (0)
The influence of mRNA stability on glucose transporter gene expression. (2000) (0)
ATM regulates a DNAdamage response posttranscriptional RNAoperon in lymphocytes (2016) (0)
Polycistronic vesicular stomatitis virus RNA transcripts ( transcription / polyadenylylation / sequence determination (0)
The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs (1989) (0)
Vesicular stomatitis virus defective interfering particle containing a muted internal leader RNA gene (initiation sites/termination sites/generation of defective particles/autointerference) (2017) (0)
Molecular analysis of the U2 snRNP unique protein A′ (1987) (0)
RNA-Binding Protein IGF2BP3 Regulates Cell Fate Decisions that Drive Cirrhosis Pathogenesis (2017) (0)
Downregulation of RNA polymerase III transcription of the hY3 gene in vitro (2004) (0)
Decision letter: Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails (2020) (0)
Characterization of a Drosophila U snRNP RNA-binding protein (2004) (0)
Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs (2014) (0)
The U1 RNBA Binding Site of the U1 snRNP-Associated A Protein Overlaps an Anti-U1 RNA Antibody Binding Site (1989) (0)
The Human La Autoantigen Contains an RNA Binding Domain and an ATP Binding Domain (1989) (0)
Special Topic: Frontiers in RNA Research The globalization of messenger RNA regulation (2014) (0)
Abstract P6-07-06: Post-transcriptional coordination of gene expression during breast cancer tumorigenesis (2015) (0)
INTERACTIONS BETWEEN CELLULAR LA PROTEIN AND LEADER RNAs (1984) (0)
RECOMBINATION EVENTS DURING THE GENERATION OF DI RNAS OF VSV (1984) (0)
The U1 RNA-specific 70K protein: RNA-binding studies and autoimmune cross-reactivity with type-C retroviruses (1987) (0)
contacts between theRNA polymerase of vesicular stomatitis virus andtheleader RNA gene (1981) (0)
76 Posttranscriptional control of gene expression in activated T cells (2000) (0)
The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation (2023) (0)
Specificity analysis of anti-La autoantibodies using cloned La fusion proteins (1989) (0)
Validation of a novel transgenic mouse model for the isolation of endothelial-specific transcripts by ribonucleoprotein (RNP) tagging (2008) (0)
Molecular characterization of the Ro small cytoplasmic RNPS (1987) (0)
The RNA binding protein, HuR, posttranscriptionally regulates the expression of chemokines and cytokines☆ (2004) (0)
Effects on the assembly and processing of snRNPs during infections with VSV and influenza virus (1985) (0)
Isolation and analysis of cDNA cloi lupus La antigen (systemic lupus erythematosus/small nuclear ribonucleoprotein/ELID (2016) (0)
Procede de derivation des epitopes (1993) (0)
The Binding of Anti-La Antibodies to Fusion Proteins Containing Various La Epitopes (1989) (0)
Emerging tools for exploring RNA regulation (LL4-3)Chairperson: Ichiro Yahara (2010) (0)

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