Jack L. Feldman

Q: What Schools Are Affiliated With Jack L. Feldman

Jack L. Feldman is affiliated with the following schools: University of California, Los Angeles, University of Chicago, University of Auckland

Jack L. Feldman's AcademicInfluence.com Rankings

Jack L. Feldman

Biology

#7030

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#9877

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Physiology

#251

World Rank

#452

Historical Rank

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Biology

Why Is Jack L. Feldman Influential?

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According to Wikipedia, Jack L. Feldman is an American neuroscientist, David Geffen School of Medicine Chair in Neuroscience and Distinguished Professor of Neurobiology at the University of California, Los Angeles . His research contributions include elucidating the mechanisms underlying breathing and sighing. He discovered and named the pre-Bötzinger complex, an area in the brain stem that is responsible for controlling breathing. He was the recipient of the Hodgkin–Huxley–Katz Prize from the Physiological Society in 2017.

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Jack L. Feldman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. (1991) (1976)
Breathing: rhythmicity, plasticity, chemosensitivity. (2003) (828)
Looking for inspiration: new perspectives on respiratory rhythm (2006) (785)
PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. (1998) (598)
Synaptic control of motoneuronal excitability. (2000) (579)
Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex. (1999) (571)
Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons (2001) (532)
Brainstem network controlling descending drive to phrenic motoneurons in rat (1994) (451)
Brainstem projections to the major respiratory neuron populations in the medulla of the cat (1989) (402)
Distinct rhythm generators for inspiration and expiration in the juvenile rat (2006) (378)
Understanding the rhythm of breathing: so near, yet so far. (2013) (375)
In vitro brainstem-spinal cord preparations for study of motor systems for mammalian respiration and locomotion (1987) (338)
Opioid-Induced Quantal Slowing Reveals Dual Networks for Respiratory Rhythm Generation (2003) (332)
Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids. (1993) (319)
Breathing matters (2018) (312)
Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. (1990) (303)
Sodium and Calcium Current-Mediated Pacemaker Neurons and Respiratory Rhythm Generation (2005) (295)
Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat (2008) (288)
Respiratory Rhythm An Emergent Network Property? (2002) (257)
Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat. (1991) (249)
Electrical Coupling and Excitatory Synaptic Transmission between Rhythmogenic Respiratory Neurons in the PreBötzinger Complex (2000) (247)
Neural mechanisms generating locomotion studied in mammalian brain stem‐spinal cord in vitro (1988) (236)
Respiratory rhythm generation and synaptic inhibition of expiratory neurons in pre-Bötzinger complex: differential roles of glycinergic and GABAergic neural transmission. (1997) (229)
Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons (2005) (218)
Inspiratory bursts in the preBötzinger complex depend on a calcium‐activated non‐specific cation current linked to glutamate receptors in neonatal mice (2007) (211)
Active Expiration Induced by Excitation of Ventral Medulla in Adult Anesthetized Rats (2011) (206)
Cellular Mechanisms Underlying Modulation of Breathing Pattern in Mammals a (1989) (196)
Pacemaker behavior of respiratory neurons in medullary slices from neonatal rat. (1994) (194)
Differential innervation of protruder and retractor muscles of the tongue in rat (1995) (187)
Brainstem connections of the rostral ventral respiratory group of the rat (1990) (180)
Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. (1993) (178)
Monosynaptic transmission of respiratory drive to phrenic motoneurons from brainstem bulbospinal neurons in rats (1988) (176)
Neurophysiology of Breathing in Mammals (1986) (173)
Opioid‐resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat (2002) (170)
Central coordination of respiratory and cardiovascular control in mammals. (1988) (160)
Projections from the ventral respiratory group to phrenic and intercostal motoneurons in cat: an autoradiographic study (1985) (160)
Excitatory amino acid-mediated transmission of inspiratory drive to phrenic motoneurons. (1990) (159)
Subnuclear organization of the lateral tegmental field of the rat. I: Nucleus ambiguus and ventral respiratory group (1990) (152)
Interaction of pulmonary afferents and pneumotaxic center in control of respiratory pattern in cats. (1976) (151)
The peptidergic control circuit for sighing (2016) (143)
Breathing control center neurons that promote arousal in mice (2017) (142)
Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cord in vitro. (1992) (141)
Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation (2007) (140)
The effects of microstimulation and microlesions in the ventral and dorsal respiratory groups in medulla of cat (1982) (136)
Projections of preBötzinger Complex neurons in adult rats (2010) (134)
Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms. (1996) (131)
Role of Inhibition in Respiratory Pattern Generation (2013) (130)
Pre-Bötzinger complex in cats: respiratory neuronal discharge patterns (1992) (126)
Neurogenesis of respiratory rhythm and pattern: emerging concepts. (1990) (119)
Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro. (1994) (116)
Powerful inhibition of pontine respiratory neurons by pulmonary afferent activity (1976) (115)
Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons (2004) (112)
Role of Parafacial Nuclei in Control of Breathing in Adult Rats (2015) (111)
Glycinergic Pacemaker Neurons in PreBötzinger Complex of Neonatal Mouse (2010) (107)
Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat? (1989) (104)
Neural control of respiratory pattern in mammals: an overview (1995) (101)
Discharge properties of dorsal medullary inspiratory neurons: relation to pulmonary afferent and phrenic efferent discharge. (1984) (100)
Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo (2016) (98)
Distinct Inspiratory Rhythm and Pattern Generating Mechanisms in the preBötzinger Complex (2013) (97)
Acetylcholine modulates respiratory pattern: effects mediated by M3-like receptors in preBötzinger complex inspiratory neurons. (2000) (97)
Afferent projections to the inspiratory neuronal region of the ventrolateral nucleus of the tractus solitarius in the cat (1979) (91)
Decussation of bulbospinal respiratory axons at the level of the phrenic nuclei in adult rats: A possible substrate for the crossed phrenic phenomenon (1991) (90)
Generation of respiratory rhythm and pattern in mammals: insights from developmental studies (1995) (89)
Respiratory activity in retrotrapezoid nucleus in cat. (1990) (88)
Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat (2002) (84)
Calcium-dependent plateau potentials in rostral ambiguus neurons in the newborn mouse brain stem in vitro. (1997) (83)
Functional respiratory rhythm generating networks in neonatal mice lacking NMDAR1 gene. (1997) (83)
Optogenetic perturbation of preBötzinger Complex inhibitory neurons modulates respiratory pattern (2015) (83)
Ventral respiratory group projections to phrenic motoneurons: Electron microscopic evidence for monosynaptic connections (1990) (82)
Efferent projections of excitatory and inhibitory preBötzinger Complex neurons (2018) (82)
Phrenic motoneuron morphology in the neonatal rat (1991) (81)
Mechanisms underlying regulation of respiratory pattern by nicotine in preBötzinger complex. (2001) (80)
Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal. (2006) (78)
Cholinergic neurotransmission in the preBÖtzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm (2005) (78)
Subnuclear organization of the lateral tegmental field of the rat. II: Catecholamine neurons and ventral respiratory group (1990) (77)
Interactions among inspiratory neurons in dorsal and ventral respiratory groups in cat medulla. (1983) (76)
Monoaminergic and gabaergic terminations in phrenic nucleus of rat identified by immunohistochemical labeling (1989) (74)
Episodic Stimulation of α1-Adrenoreceptors Induces Protein Kinase C-Dependent Persistent Changes in Motoneuronal Excitability (2007) (73)
Caudal medullary expiratory neurone and internal intercostal nerve discharges in the cat: effects of lung inflation. (1985) (68)
Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. (2008) (68)
Facing the challenge of mammalian neural microcircuits: taking a few breaths may help (2015) (67)
Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem (1986) (66)
Synaptic interaction between medullary respiratory neurones during apneusis induced by NMDA‐receptor blockade in cat. (1992) (65)
Properties of inspiratory termination by superior laryngeal and vagal stimulation. (1979) (64)
Concurrent Inhibition and Excitation of Phrenic Motoneurons during Inspiration: Phase-Specific Control of Excitability (1999) (63)
Blockade of NMDA receptor-channels by MK-801 alters breathing in adult rats (1992) (63)
Episodic hypoxia evokes long‐term facilitation of genioglossus muscle activity in neonatal rats (2004) (63)
Interactions between respiratory oscillators in adult rats (2016) (60)
Emergence of Population Bursts from Simultaneous Activation of Small Subsets of preBötzinger Complex Inspiratory Neurons (2013) (60)
Interventions and Manipulations of Interoception (2021) (59)
Relation between expiratory duration and rostral medullary expiratory neuronal discharge (1978) (58)
Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus. (1997) (57)
Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern. (2002) (56)
Serotonergic inhibition of phrenic motoneuron activity: an in vitro study in neonatal rat (1997) (53)
Nicotinic excitation of rat hypoglossal motoneurons (2002) (53)
Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals. (2010) (51)
Central cholinergic regulation of respiration: nicotinic receptors (2009) (49)
AMPA receptor activation and phosphatase inhibition affect neonatal rat respiratory rhythm generation (1998) (48)
Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro (2004) (48)
Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro (2009) (48)
Oscillations in Endogenous Inputs to Neurons Affect Excitability and Signal Processing (2003) (48)
Modulation of AMPA receptors by cAMP‐dependent protein kinase in PreBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat (2003) (45)
Silent hypoxaemia in COVID‐19 patients (2020) (44)
Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades (2005) (43)
α4* Nicotinic Receptors in preBötzinger Complex Mediate Cholinergic/Nicotinic Modulation of Respiratory Rhythm (2008) (43)
Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats". (2006) (42)
Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons (2019) (41)
Short time scale correlations between discharges of medullary respiratory neurons. (1980) (41)
Rhythmogenic neuronal networks, emergent leaders, and k-cores. (2008) (39)
Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials (2007) (38)
NMDA receptors in preBötzinger complex neurons can drive respiratory rhythm independent of AMPA receptors (2007) (38)
Effect of synchronous activation of medullary inspiratory bulbo‐spinal neurones on phrenic nerve discharge in cat. (1984) (37)
Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation (2020) (36)
Models of respiratory phase-switching. (1977) (36)
Distinct Subtypes of Metabotropic Glutamate Receptors Mediate Differential Actions on Excitability of Spinal Respiratory Motoneurons (1999) (36)
Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons (2008) (34)
Multiple Actions of 1S,3R-ACPD in Modulating Endogenous Synaptic Transmission to Spinal Respiratory Motoneurons (1996) (31)
Origins of excitatory drive within the respiratory network: anatomical localization. (1994) (31)
Respiratory pattern generation in mammals: in vitro en bloc analyses (1992) (30)
Sighs and gasps in a dish (2000) (29)
Reelin demarcates a subset of pre‐Bötzinger complex neurons in adult rat (2012) (28)
Multiple putative neuromessenger inputs to the phrenic nucleus in rat (1992) (27)
Phasic Vagal Sensory Feedback Transforms Respiratory Neuron Activity In Vitro (2001) (27)
Pulmonary Afferent Influences on Respiratory Modulation of Sympathetic Discharge (1980) (27)
Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats (2017) (27)
Dynamic Modulation of Inspiratory Drive Currents by Protein Kinase A and Protein Phosphatases in Functionally Active Motoneurons (2003) (26)
Distinct parafacial regions in control of breathing in adult rats (2018) (26)
Glutamate release and presynaptic action of AP4 during inspiratory drive to phrenic motoneurons (1992) (26)
RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Bötzinger complex. (2001) (24)
Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation. (2002) (24)
Quantal synaptic transmission in phrenic motor nucleus. (1992) (24)
Bulbospinal respiratory neurons are a source of double synapses onto phrenic motoneurons following cervical spinal cord hemisection in adult rats (1993) (23)
Chapter 14--looking forward to breathing. (2011) (23)
Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA (2004) (22)
Nicotine delivery to rats via lung alveolar region-targeted aerosol technology produces blood pharmacokinetics resembling human smoking. (2013) (22)
Respiratory pattern generation in mammals: in vitro en bloc analyses (1991) (22)
Generation of respiratory patterns in mammals (1988) (21)
Intracellular recording from phrenic motoneurons receiving respiratory drive in vitro (1988) (21)
Practice makes perfect, even for breathing (2009) (20)
Opioids modulate an emergent rhythmogenic process to depress breathing (2019) (19)
Facts and challenges in respiratory neurobiology (2015) (19)
Intrinsic and extrinsic factors affecting phrenic motoneuronal excitability in neonatal rats (1997) (19)
Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms (2004) (17)
Identifying neurons in the PreBötzinger complex that generate respiratory rhythm: Visualizing the ghost in the machine (2001) (17)
Slip of the tongue. (2004) (15)
Breathing Rhythm and Pattern and Their Influence on Emotion. (2022) (15)
Functional heterogeneity of dorsal, ventral and pontine respiratory groups revealed by micropharmacological techniques (1987) (15)
Research Priorities for Patients with Heart Failure and Central Sleep Apnea. An Official American Thoracic Society Research Statement (2021) (13)
Role of the ventrolateral region of the nucleus of the tractus solitarius in processing respiratory afferent input from vagus and superior laryngeal nerves (1987) (12)
Interactions between brainstem respiratory neurons. (1981) (10)
Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC (2007) (9)
The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal". (2006) (9)
Precision Medicine for Breath-Focused Mind-Body Therapies for Stress and Anxiety: Are We Ready Yet? (2021) (8)
A network model for control of inspiratory cutoff by the pneumotaxic center with supportive experimental data in cats (1976) (8)
Central neural production of periodic respiratory movements (1982) (8)
Central mechanisms controlling expiratory duration. (1978) (6)
Neural Control of Respiratory and Cardiovascular Functions (2013) (5)
Chronic intermittent nicotine delivery with lung alveolar region-targeted aerosol technology produces circadian blood pharmacokinetics in rats resembling human smokers (2017) (5)
Respiratory Central Pattern Generator (2010) (5)
Facing the challenge of mammalian neural microcircuits: Taking a few breaths may help. (2014) (5)
Protein kinase G‐dependent mechanisms modulate hypoglossal motoneuronal excitability and long‐term facilitation (2010) (4)
Phase‐ and state‐dependent modulation of breathing pattern by preBötzinger complex somatostatin expressing neurons (2021) (4)
Cyclothiazide‐induced persistent increase in respiratory‐related activity in vitro (2012) (3)
Nervous System Research with RIP Conjugates (2014) (3)
Brainstem Respiratory Circuits (2009) (3)
Microcircuit synchronization and heavy tailed synaptic weight distribution in preBötzinger Complex contribute to generation of breathing rhythm (2020) (3)
Generation of respiratory rhythm in mammals (2009) (3)
Neurobiology of Breathing Control (1995) (3)
Role of the dorsal and ventral respiratory groups: Generation of respiratory rhythm (1985) (2)
Role of the dorsal respiratory group (DRG): Processing of vagal and superior laryngeal nerve afferent input (1987) (2)
Inspiratory rhythmogenic activity is burst-independent and opioid-sensitive (2019) (2)
Neonatal Mice Lacking NMDAR 1 Gene Functional Respiratory Rhythm Generating Networks in (1997) (2)
In vitro studies of mammalian respiration and locomotion (1986) (2)
Network synchronization and synchrony propagation: emergent elements of inspiration (2019) (2)
Phase- and State-Dependent Modulation of Breathing Pattern by preBötzinger Complex Somatostatin Expressing Neurons (2021) (1)
Neurobiology of breathing control. Where to look and what to look for. (1995) (1)
AGE-RELATED EFFECTS OF ONLINE EMOTION REGULATION STRATEGIES ON MOOD AND MEMORY (2007) (1)
Microinjection of (sub)picomoles of excitatory amino acids into cat or rat brainstem alters respiratory and cardiovascular motor control (1986) (1)
Role of the dorsal and ventral respiratory groups: Generation of spatiotemporal patterns of motoneuronal activity (1985) (1)
Functional Relations Between Dorsal Medullary Inspiratory Neurons and Phrenic Motoneurons (1983) (1)
Author response: Interactions between respiratory oscillators in adult rats (2016) (1)
A stereotaxic system for independent coordinated positioning of two or three microelectrodes (1982) (1)
Respiratory Central Pattern Generator: Microcircuit Generation of the Rhythms and Patterns of Breathing (2017) (1)
Perturbation of cardiovascular function by picomoles of L-glutamate injected into rat brainstem (1985) (1)
Faculty Opinions recommendation of Respiratory control by ventral surface chemoreceptor neurons in rats. (2004) (0)
Projection and function of bulbospinal neurons in the dorsal and ventral respiratory groups of cats (1984) (0)
Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics (2022) (0)
Reciprocal inhibition of expiratory neurons is glycinergic and not required for rhythm generation (1995) (0)
Brain Stem Spinal Cord Respiratory Period in the Lung-Attached Neonate Rat Phasic Lung Inflation Shortens Inspiration and (2015) (0)
RatsRetrotrapezoid Nucleus Chemoreceptors in Receptor-Expressing C-Fiber Vagal Afferents Activation of 5-Hydroxytryptamine Type 3 (2015) (0)
Decision letter: ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression (2020) (0)
Control of breathing: chemoreception, neuroplasticity, integrated responses and disorders of ventilatory control (2009) (0)
Model Predictions Pre-Bötzinger Complex. III. Experimental Tests of Models of Respiratory Rhythm Generation in the (2015) (0)
Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats (2017) (0)
Faculty Opinions recommendation of Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. (2004) (0)
hypoxia in rat response to hypoxia following acute intermittent 5-HT-mediated long-term facilitation and enhanced Recurrent laryngeal nerve activity exhibits a (2015) (0)
With the Respiratory CPG Late-Expiratory Activity: Emergence and Interactions (2015) (0)
Faculty Opinions recommendation of V1 spinal neurons regulate the speed of vertebrate locomotor outputs. (2006) (0)
Breathing matters (2018) (0)
Respiratory motor discharge altered by picomole glutamate (GLU) injection into the ventral respiratory group (VRG) of cat (1985) (0)
Faculty Opinions recommendation of Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo. (2005) (0)
Organization of oscillatory motor pattern generation networks in the mammalian central nervous system (1990) (0)
Defining preBötzinger Com plex Rhythm-and Pattern-Generating Neural Microcircuits In Vivo Highlights (2016) (0)
Faculty Opinions recommendation of BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. (2004) (0)
Central Nervous System Pharmacology of the Control of Breathing (1987) (0)

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What Schools Are Affiliated With Jack L. Feldman?

Jack L. Feldman is affiliated with the following schools: