Jack W. Szostak | Academic Influence

Why Is Jack W. Szostak Influential?

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According to Wikipedia, Jack William Szostak is a Canadian American biologist of Polish British descent, Nobel Prize laureate, university professor at the University of Chicago, former Professor of Genetics at Harvard Medical School, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston. Szostak has made significant contributions to the field of genetics. His achievement helped scientists to map the location of genes in mammals and to develop techniques for manipulating genes. His research findings in this area are also instrumental to the Human Genome Project. He was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Elizabeth Blackburn and Carol W. Greider, for the discovery of how chromosomes are protected by telomeres.

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Jack W. Szostak's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

In vitro selection of RNA molecules that bind specific ligands (1990) (7830)
The double-strand-break repair model for recombination (1983) (2377)
Yeast transformation: a model system for the study of recombination. (1981) (1250)
In vitro selection of functional nucleic acids. (1999) (1024)
A DNA aptamer that binds adenosine and ATP. (1995) (975)
RNA-peptide fusions for the in vitro selection of peptides and proteins. (1997) (924)
A mutant with a defect in telomere elongation leads to senescence in yeast (1989) (904)
Synthesizing life : Paths to unforeseeable science & technology (2001) (829)
Synthesizing life (2001) (826)
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging (2006) (801)
Isolation of new ribozymes from a large pool of random sequences [see comment]. (1993) (786)
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures (1992) (693)
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division (2003) (659)
Cloning yeast telomeres on linear plasmid vectors (1982) (583)
Template-directed synthesis of a genetic polymer in a model protocell (2008) (568)
Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site (1991) (525)
An RNA motif that binds ATP (1993) (517)
DNA sequences of telomeres maintained in yeast (1984) (512)
Double-strand breaks at an initiation site for meiotic gene conversion (1989) (505)
Functional proteins from a random-sequence library (2001) (483)
Genetic applications of yeast transformation with linear and gapped plasmids. (1983) (458)
Yeast recombination: the association between double-strand gap repair and crossing-over. (1983) (402)
Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae (1980) (388)
Construction of artificial chromosomes in yeast (1983) (382)
Coupled Growth and Division of Model Protocell Membranes (2009) (380)
Structurally complex and highly active RNA ligases derived from random RNA sequences. (1995) (374)
Pedigree analysis of plasmid segregation in yeast (1983) (362)
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA (1991) (357)
The Emergence of Competition Between Model Protocells (2004) (354)
A DNA metalloenzyme with DNA ligase activity (1995) (353)
The use of mRNA display to select high-affinity protein-binding peptides (2001) (347)
The guanosine binding site of the Tetrahymena ribozyme (1989) (296)
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae (1989) (279)
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene (2006) (263)
In vitro evolution of new ribozymes with polynucleotide kinase activity (1994) (251)
The eightfold path to non-enzymatic RNA replication (2012) (244)
One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. (2001) (241)
Structural conventions for group I introns. (1987) (239)
In vitro evolution of a self-alkylatlng ribozyme (1995) (235)
Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells (2013) (234)
Progress toward synthetic cells. (2014) (215)
Ribozyme-catalysed amino-acid transfer reactions (1996) (213)
RNA Catalysis in Model Protocell Vesicles (2005) (208)
Physical effects underlying the transition from primitive to modern cell membranes (2011) (205)
A kinetic study of the growth of fatty acid vesicles. (2004) (200)
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold (2007) (198)
Competition between model protocells driven by an encapsulated catalyst. (2013) (197)
RNA-catalysed synthesis of complementary-strand RNA (1989) (194)
Informational Complexity and Functional Activity of RNA Structures (2004) (187)
Ribosomal synthesis of unnatural peptides. (2005) (187)
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. (1990) (185)
The origins of cellular life. (2010) (183)
In vitro selection of RNA aptamers specific for cyanocobalamin. (1994) (181)
Chromosome segregation in mitosis and meiosis. (1985) (179)
RNA aptamers that bind flavin and nicotinamide redox cofactors. (1995) (178)
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors (2012) (173)
Replicating vesicles as models of primitive cell growth and division. (2004) (169)
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. (2018) (168)
Telomeric repeat from T. thermophila cross hybridizes with human telomeres (1988) (168)
In vitro evolution suggests multiple origins for the hammerhead ribozyme (2001) (164)
Thermostability of model protocell membranes (2008) (163)
ARD1 and NAT1 proteins form a complex that has N‐terminal acetyltransferase activity. (1992) (163)
Ribozyme-catalyzed tRNA aminoacylation (2000) (163)
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides (2007) (153)
Scanning the human proteome for calmodulin-binding proteins (2005) (149)
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. (2004) (147)
In vitro genetics. (1992) (146)
Optimized synthesis of RNA-protein fusions for in vitro protein selection. (2000) (145)
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways (1985) (145)
Isolation of high-affinity GTP aptamers from partially structured RNA libraries (2002) (144)
Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents (1985) (144)
Transfer of yeast telomeres to linear plasmids by recombination (1984) (138)
Protocells and RNA Self-Replication. (2018) (135)
Expanding roles for diverse physical phenomena during the origin of life. (2010) (134)
Stereospecific recognition of tryptophan agarose by in vitro selected RNA (1992) (131)
Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water (2010) (129)
Enzymatic aminoacylation of tRNA with unnatural amino acids. (2006) (129)
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns (1990) (129)
mRNA display: from basic principles to macrocycle drug discovery. (2014) (128)
A Small Aptamer with Strong and Specific Recognition of the Triphosphate of ATP (2004) (127)
Chromosome length controls mitotic chromosome segregation in yeast (1986) (127)
Insertion of a genetic marker into the ribosomal DNA of yeast. (1979) (125)
Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose (2005) (123)
Formation of Protocell-like Vesicles in a Thermal Diffusion Column (2009) (118)
TNA synthesis by DNA polymerases. (2003) (113)
Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. (1996) (112)
An optimal degree of physical and chemical heterogeneity for the origin of life? (2011) (111)
Constructing high complexity synthetic libraries of long ORFs using in vitro selection. (2000) (110)
Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. (2009) (110)
Selection of a ribozyme that functions as a superior template in a self-copying reaction. (1992) (110)
Isolation and characterization of fluorophore-binding RNA aptamers. (1998) (109)
In vitro genetic analysis of the Tetrahymena self-splicing intron (1990) (108)
Aptamers selected for higher-affinity binding are not more specific for the target ligand. (2006) (106)
A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae (1991) (105)
Concentration-Driven Growth of Model Protocell Membranes (2012) (104)
Mineral Surface Directed Membrane Assembly (2007) (104)
An alternative pathway for meiotic chromosome segregation in yeast. (1986) (103)
Photochemically driven redox chemistry induces protocell membrane pearling and division (2012) (102)
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides (2017) (101)
Functional information and the emergence of biocomplexity (2007) (99)
Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication (2010) (99)
Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. (1990) (99)
Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. (1996) (99)
Origins of life: Systems chemistry on early Earth (2009) (98)
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. (1991) (98)
DNA polymerase-mediated DNA synthesis on a TNA template. (2003) (97)
Chance and necessity in the selection of nucleic acid catalysts. (1996) (95)
The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life. (2017) (94)
Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot. (1998) (91)
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus (1987) (91)
Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides (2016) (91)
Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. (1990) (89)
Isolation of a fluorophore-specific DNA aptamer with weak redox activity. (1998) (89)
Reconstructing the emergence of cellular life through the synthesis of model protocells. (2009) (89)
RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. (1989) (87)
Is there left-handed DNA at the ends of yeast chromosomes? (1983) (87)
Enzymatic activity of the conserved core of a group I self-splicing intron (1986) (87)
Fungal recombination (1985) (84)
High fidelity TNA synthesis by Therminator polymerase (2005) (84)
Ribosomal Synthesis of N-Methyl Peptides (2008) (83)
Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe (1987) (83)
Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers (2009) (81)
A simple method for 3'-labeling of RNA. (1996) (81)
Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. (2013) (81)
Stereochemical course of catalysis by the Tetrahymena ribozyme. (1989) (81)
Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae (1987) (79)
UV-light-driven prebiotic synthesis of iron-sulfur clusters. (2017) (79)
An in Vitro Selection System for TNA (2005) (79)
Kinetic Analysis of an Efficient DNA-Dependent TNA Polymerase (2005) (79)
Cloning regulated yeast genes from a pool of lacZ fusions. (1983) (77)
Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae (1988) (76)
Functional information: Molecular messages (2003) (76)
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets (2014) (76)
Ribosomal synthesis of dehydroalanine-containing peptides. (2006) (75)
1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. (1994) (73)
Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. (2003) (72)
In Vitro Selection of Specific Ligand‐binding Nucleic Acids (1992) (72)
Multiple, Tandem Plasmid Integration in Saccharomyces cerevisiae (1983) (72)
Preparation of Large Monodisperse Vesicles (2009) (71)
A simple physical mechanism enables homeostasis in primitive cells (2016) (70)
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template (2007) (66)
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides (2017) (65)
Ribozymes: aiming at RNA replication and protein synthesis. (1996) (65)
Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. (1995) (62)
Attempts to Define Life Do Not Help to Understand the Origin of Life (2012) (62)
A strategy for the generation of conditional mutations by protein destabilization. (1992) (62)
Solution structure of an informationally complex high-affinity RNA aptamer to GTP. (2006) (62)
Identification of epitope‐like consensus motifs using mRNA display (2002) (62)
Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions (2014) (62)
Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer (2013) (61)
Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension (2015) (61)
A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. (2003) (60)
Mutational analysis of conserved nucleotides in a self-splicing group I intron. (1990) (59)
Copying of Mixed-Sequence RNA Templates inside Model Protocells (2018) (57)
A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension (2016) (57)
Unusual metal ion catalysis in an acyl-transferase ribozyme. (1998) (57)
20 In Vitro Selection of Functional RNA Sequences (1993) (56)
Isolation of novel ribozymes that ligate AMP-activated RNA substrates. (1997) (56)
DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA (1981) (55)
Multicomponent Assembly of Proposed DNA Precursors in Water (2012) (54)
Gene conversion adjacent to regions of double-strand break repair (1988) (54)
In vitro selection of catalytic RNAs. (1994) (54)
In vitro genetic analysis: Selection and amplification of rare functional nucleic acids (1991) (54)
N2′→P3′ Phosphoramidate Glycerol Nucleic Acid as a Potential Alternative Genetic System (2009) (53)
Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation (2017) (53)
Hybridization with synthetic oligonucleotides. (1979) (53)
Introduction: Combinatorial Chemistry. (1997) (52)
Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity (2011) (52)
Collaboration between primitive cell membranes and soluble catalysts (2016) (52)
Isolation of a ribozyme with 5'-5' ligase activity. (1995) (51)
The Origins of Nucleotides (2011) (51)
In Vitro Selection of Functional Lantipeptides (2012) (50)
Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. (2018) (48)
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. (2000) (46)
Structural and kinetic characterization of an acyl transferase ribozyme. (1998) (45)
Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization (2015) (44)
Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. (2008) (44)
Origin of life on earth. (2009) (44)
Single-Molecule Imaging of an in Vitro-Evolved RNA Aptamer Reveals Homogeneous Ligand Binding Kinetics (2009) (42)
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA (2018) (40)
Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension (2012) (40)
Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. (1995) (40)
Recombination between sequences in nonhomologous positions. (1983) (40)
Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae (1986) (39)
Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides (2015) (39)
In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. (1994) (39)
Structural insights into the effects of 2′-5′ linkages on the RNA duplex (2014) (39)
Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs (2014) (38)
Oligoarginine Peptides Slow Strand Annealing and Assist Nonenzymatic RNA Replication (2016) (38)
Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. (1997) (38)
Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. (1990) (37)
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes (2016) (37)
Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. (1993) (37)
Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. (2006) (36)
Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. (2004) (36)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme. (1991) (35)
Activated Ribonucleotides Undergo a Sugar Pucker Switch upon Binding to a Single-Stranded RNA Template (2012) (35)
Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. (2006) (35)
Miniribozymes, small derivatives of the sunY intron, are catalytically active (1989) (34)
Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA (1977) (34)
Artificial lantipeptides from in vitro translations. (2011) (32)
Meiotic recombination on artificial chromosomes in yeast. (1992) (31)
A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide (2017) (30)
Replication and resolution of telomeres in yeast. (1983) (30)
The Free Energy Landscape of Pseudorotation in 3′–5′ and 2′–5′ Linked Nucleic Acids (2014) (29)
Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. (1991) (28)
Synthesis and Nonenzymatic Template-Directed Polymerization of 2′-Amino-2′-deoxythreose Nucleotides (2014) (27)
3 Protocells: Genetic Polymers Inside Membrane Vesicles (2006) (26)
Bulk Self-Assembly of Giant, Unilamellar Vesicles. (2020) (25)
Unusual Base-Pairing Interactions in Monomer–Template Complexes (2016) (24)
Controlled Growth of Filamentous Fatty Acid Vesicles under Flow (2014) (23)
Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells (2019) (23)
Fungal recombination. (1985) (23)
Single-molecule binding experiments on long time scales. (2010) (22)
Uncovering the Thermodynamics of Monomer Binding for RNA Replication (2015) (21)
Synthesis of α-l-Threofuranosyl Nucleoside Triphosphates (tNTPs) (2005) (21)
Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. (2019) (21)
Non-enzymatic primer extension with strand displacement (2019) (21)
Enzymatic Primer-Extension with Glycerol-Nucleoside Triphosphates on DNA Templates (2009) (21)
Shrink-wrap vesicles. (2005) (21)
The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. (2019) (20)
Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization (2007) (20)
Generation of Functional RNAs from Inactive Oligonucleotide Complexes by Non-enzymatic Primer Extension (2014) (19)
Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms (2015) (19)
Template‐Directed Copying of RNA by Non‐enzymatic Ligation† (2020) (19)
Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex (2017) (19)
Crystallographic observation of nonenzymatic RNA primer extension (2018) (19)
Roles of the 2 , um Gene Products in Stable Maintenance of the 2 iim Plasmid of Saccharomyces cerevisiae (18)
Genetic dissection of an RNA enzyme. (1987) (17)
UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth (2019) (17)
Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom (2016) (17)
A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides (2020) (17)
Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (2008) (17)
Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides (2015) (17)
Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. (2011) (17)
DNA ends: just the beginning (Nobel lecture). (2010) (16)
[18] Yeast vectors with negative selection (1983) (16)
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes (2017) (16)
Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. (2019) (16)
Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean–Archaean Earth (2018) (16)
Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide (2018) (16)
Structure and evolutionary analysis of a non-biological ATP-binding protein. (2007) (15)
In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity (2006) (15)
Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension (2018) (15)
A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension (2017) (14)
In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates (2020) (14)
Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis (2016) (14)
Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying (2020) (14)
Ribozyme catalysis (1992) (13)
Exploding vesicles (2011) (13)
Yeast vectors with negative selection. (1983) (13)
In vitro selection of RNA aptamers against a composite small molecule-protein surface (2005) (13)
Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II) (2018) (13)
The virtual circular genome model for primordial RNA replication (2020) (13)
Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation (2020) (12)
Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. (2016) (12)
Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water (2011) (12)
2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. (2007) (11)
Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. (1994) (11)
Genetic and physical analyses of sister chromatid exchange in yeast meiosis (1991) (11)
A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2’-deoxynucleotides (2019) (11)
Transfer of Sequence Information and Replication of Diimine Duplexes (2019) (11)
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution (2017) (11)
Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. (1994) (10)
Selection of Functional RNA and DNA Molecules from Randomized Sequences (1993) (10)
The beginning of the ends (1989) (10)
Lipid constituents of model protocell membranes. (2019) (10)
Mutations in a semiconserved region of the Tetrahymena intron (1991) (10)
Deep sequencing of non-enzymatic RNA primer extension (2020) (10)
How Did Life Begin? (2018) (10)
Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. (2013) (10)
Conformational Analysis of DNA Repair Intermediates by Time-Resolved Fluorescence Spectroscopy (2009) (9)
Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage (2019) (9)
Total chemical synthesis of a ribozyme derived from a group I intron. (1995) (9)
Preparation, Purification, and Use of Fatty Acid-containing Liposomes (2018) (9)
A rapid procedure for the construction of linear yeast plasmids. (1983) (9)
Evolution ex vivo (1993) (9)
Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. (1990) (9)
SEXUAL INDUCTION IN EUDORINA: EFFECTS OF LIGHT, NUTRIENTS, AND CONDITIONED MEDIUM 1 (1973) (8)
A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying. (2018) (8)
Preparation of fatty acid micelles. (2013) (8)
Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations (2015) (8)
Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. (2017) (8)
Large phenotypic enhancement of structured random RNA pools. (2019) (8)
The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis. (2021) (8)
Material for A Genomewide Search for Ribozymes Reveals an HDV-like Sequence in the Human CPEB 3 Gene (2006) (8)
Molecular biology: RNA gets a grip on translation (2002) (7)
Structure and Activity of Ribozymes (1988) (7)
Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage (2019) (7)
In search of the RNA world on Mars (2020) (7)
Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. (2013) (7)
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression. (2020) (7)
Selective labeling and detection of specific RNAs in an RNA mixture. (2003) (7)
The Origin of Life on Earth and the Design of Alternative Life Forms (2017) (6)
In vitro selection and directed evolution. (1997) (6)
Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. (2016) (6)
Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension (2017) (6)
Ray Wu, as remembered by a former student (2009) (6)
Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase (2020) (6)
DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates (2019) (6)
LIFE ON EARTH (2009) (5)
Not just Salk (2017) (5)
In vitro Selection of Specific Ligand-Binding Nucleic Acids (1992) (5)
Assembly of a functional ribozyme from short oligomers by enhanced non-enzymatic ligation (2019) (5)
Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. (2016) (5)
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry (2020) (4)
Erratum: Competition between model protocells driven by an encapsulated catalyst (2013) (4)
Erratum: Scanning the human proteome for calmodulin-binding proteins (Proceedings of the National Academy of Sciences of the United States of America (April 26, 2005) 102, 17 (5969-5974)) (2005) (4)
Molecular diversity comes of age ! (1995) (4)
Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension (2021) (4)
Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth (2021) (4)
[17] Construction of specific chromosomal rearrangements in yeast (1983) (4)
Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions (2020) (3)
Telomerase: the beginning of the ends. (1989) (3)
Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying (2021) (3)
Models of Protocellular Structure, Function and Evolution (2001) (3)
The origins of life : a subject collection from Cold Spring Harbor perspectives in biology (2010) (3)
Bacterial carotenoids suppress Caenorhabditis elegans surveillance and defense of translational dysfunction (2020) (3)
Construction of specific chromosomal rearrangements in yeast. (1983) (3)
Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine (2019) (3)
The ascent of molecules. (2013) (3)
Telomeres and artificial chromosomes in yeast (1984) (3)
Models of the Protocellular Structures, Functions and Evolution (2000) (2)
Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates (2021) (2)
Interpreting turbidity measurements for vesicle studies (2018) (2)
Steps toward a Synthetic Protocell (2008) (2)
Chance and Necessity in the Selection of Nucleic Acid Catalysts (1996) (2)
Functional RNAs exhibit tolerance for non-heritable 2 9 – 5 9 versus 3 9 – 5 9 backbone heterogeneity (2013) (2)
Solid-Phase Synthesis of Sequence-Defined Informational Oligomers (2020) (2)
Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides (2021) (2)
4 Towards non-enzymatic RNA replication (2013) (2)
Chemical Synthesis of Oligoribonucleotides Containing 2‐Aminopurine: Substrates for the Investigation of Ribozyme Function. (1991) (2)
Template-Free Assembly of Functional RNAs by Loop-Closing Ligation (2022) (2)
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization (2020) (2)
Retraction for Litovchick and Szostak, Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (2009) (2)
The Mechanism of Nonenzymatic Template Copying with Imidazole‐Activated Nucleotides (2019) (2)
‘Fair is Foul, and Foul is Fair’: Kyoto Nihonga, Anti-Bijin Portraiture and the Psychology of the Grotesque (2012) (2)
Deciphering nonenzymatic RNA polymerization through crystallography (2018) (1)
RNA-catalysed synthesis of complementary strand RNA (1989) (1)
Nonenzymatic loop-closing ligation generates RNA hairpins and is a template-free way to assemble functional RNAs (2021) (1)
Designing Biomimetic, Dissipative Material Systems (2016) (1)
Ribozymes. Evolution ex vivo. (1993) (1)
Two Paths to the Pure Land: The Niga-byakudō Theme and the Modernist Buddhist Art of Hada Teruo (2007) (1)
Painting Circles: Tsuchida Bakusen and Nihonga Collectives in Early Twentieth Century Japan (2013) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template and primer containing an N3'-> P5' linkage (2020) (1)
Use Of Single-Molecule Imaging To Analyze The Distribution Of Binding Ability In RNA Aptamer Populations (2009) (1)
Prebiotically Plausible Activation Chemistry Compatible with Nonenzymatic RNA Copying (2020) (1)
50 ideas to change science Part one Life and Earth (2010) (1)
Structure-activity relationships in nonenzymatic template-directed RNA synthesis. (2021) (1)
On the origin of life. (2016) (1)
Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides (2022) (1)
4 In Vitro Selection of Nucleic Acid Sequences that Bind Small Molecules (1996) (1)
Self-assembly of model protocell membranes (2018) (1)
aptamer to GTP Solution structure of an informationally complex high-affinity RNA (2006) (1)
5 Efficient and high-fidelity copying of an RNA-like model prebiotic system (2013) (1)
Chapter 7:Mammalian Self-Cleaving Ribozymes (2007) (1)
DNA ENDS: JUST THE BEGINNING (2009) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, 3'-amino primer, dGpNHpp analog, and Mn2+ (2020) (1)
Author response: Crystallographic observation of nonenzymatic RNA primer extension (2018) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template and 3'-amino primer (2020) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, dideoxy primer, 3'-amino-ddGTP (nGTP), and Ca2+ (2020) (1)
Structural Insights into the Evolution of a Non-Biological Protein (2007) (0)
Self-complimentary RNA 15mer binding with GMP monomers (2016) (0)
GeneConversion Adjacent toRegions ofDouble-Strand BreakRepair (1988) (0)
Telomere DNA protects the chromosomes (2010) (0)
Crystal Structures of RNA Duplexes Containing 2-thio-Uridine (2014) (0)
Template‐Directed Copying of RNA by Non‐enzymatic Ligation (2020) (0)
University of Groningen Single-molecule binding experiments on long time scales Elenko, (2010) (0)
Rolesofthe2,umGeneProducts inStable Maintenance ofthe2iim Plasmid ofSaccharomyces cerevisiae (1987) (0)
High resolution RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G (2021) (0)
Artistic Flowering: The Second and Third Kokuten Exhibitions (2013) (0)
Artificial lantipeptides from in vitro translations w (2011) (0)
Non-enzymatic primer extension with strand displacement 1 (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue-3 binding sites (2016) (0)
RNA-activated 2-AIpG monomer complex, 30 min soaking (2018) (0)
How Did Life Begin? (2018) (0)
RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue (2018) (0)
RNA-imidazolium-bridged intermediate complex, 4h soaking (2018) (0)
RNA primer-template complex with guanosine dinucleotide p(5')G(3')p(5')G ligand (2017) (0)
RNA 10mer duplex with six 2'-5'-linkages (2014) (0)
50 ideas to change science: Artificial life (2010) (0)
Challenges, Changes, and Evolving Strategies at the Bunten (2013) (0)
Cooperativity and Downstream Binding in RNA Replication (2016) (0)
3'-deoxy modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G (2021) (0)
Class I GTP aptamer (2006) (0)
RNA hairpin structure containing 2-MeImp-oligo analogue (2018) (0)
Views of Ryukyu:Paintings and Prints in the Hamilton Library Collection (2013) (0)
Physical Models for Early Membrane Growth and Evolution (2013) (0)
Protocells Nonenzymatic Template-Directed RNA Synthesis Inside Model (2013) (0)
RNA hairpin structure containing one TNA nucleotide as template (2020) (0)
Immune Quiescence The Hedgehog Pathway Promotes (2012) (0)
Abstract: The earth sciences: new resources for teachers (1995) (0)
Native 7mer-RNA duplex (2014) (0)
RNA-activated 2-AIpG monomer complex, 5 min soaking (2018) (0)
RNA-monomer complex containing pyrophosphate linkage (2019) (0)
RNA-activated 2-AIpG monomer complex, 1h soaking (2018) (0)
The Origins of Cellular Life service (2010) (0)
Miniribozymes, SmallDerivatives ofthesunYIntron, Are Catalytically Active (1989) (0)
RNA-dGMP complex with Sr ion (2018) (0)
Emergence of Primordial Enzymes from Mixtures of Random Peptides (2010) (0)
RNA-dGMP complex with Mg ion (2018) (0)
RNA oligonucleotides with 3'-arabino guanosine co-crystallized with GMP (2020) (0)
Telomeres and Telomerase in Cellular Aging (Senescence) (2017) (0)
Deep Phylogeny (2010) (0)
7 Imperfect RNA synthesis via model prebiotic reactions and consequences for functional RNAs (2013) (0)
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets (2014) (0)
Native RNA-10mer Structure: ccggcgccgg (2014) (0)
RNA duplex containing UU mispair (2014) (0)
8 Using pseudorotation as a reaction coordinate in free energy simulations of nucleic acids (2013) (0)
Approaches to the selection of an RNA replicase (1994) (0)
RNA-activated 2-AIpG monomer, 1.5h soaking (2018) (0)
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML (1990) (0)
RNA hairpin, bound with TNA monomer (2020) (0)
Nonenzymatic RNA-templated Synthesis of N3'→P5' Phosphoramidate DNA. (2020) (0)
The Hayflick Limit (2017) (0)
Picturing the Ryukyus: Other Images in the Sakamaki-Hawley Collection (2013) (0)
A strategy forthegeneration ofconditional mutations byprotein destabilization (1992) (0)
Carol Widney Greider (1961-) (2019) (0)
Genetic andPhysical Analyses ofSister Chromatid Exchange inYeastMeiosis (1991) (0)
RNA-activated 2-AIpG monomer complex, 2h soaking (2018) (0)
In vitro selection of novel ligase ribozymes (1996) (0)
The Yeast ARD] Gene Product Is Required for Repression of Cryptic Mating-Type Information at the HML Locust (2014) (0)
A simple method for 34-labeling of RNA (1996) (0)
Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides (2021) (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites (2016) (0)
RNA hairpin structure containing 2-MeImpG analogue bound (2018) (0)
RNA duplex bound with TNA 3'-3' imidazolium dimer (2020) (0)
Origin of life on earth. (Cover story) (2009) (0)
The Inaugural Kokuten Exhibition of 1918: Content and Contexts (2013) (0)
The Modernist Traditionalism of Isamu Noguchi and Hasegawa Saburo (2021) (0)
Hiatus, Expansion, and Collapse: The Kokuten’s Middle and Final Stages (2013) (0)
RNA hairpin structure containing 2-MeImpG monomer analogue and 2-MeImp-oligomer analogue (2018) (0)
Documents Related to the Kokuga Sōsaku Kyōkai (2013) (0)
Making Modern Japanese-Style Painting: Kano Hōgai and the Search for Images by Chelsea Foxwell (review) (2019) (0)
“Art Is Something Born”: The Rise and Fall of the Kokuga Society (1918–28) and the Emergence of the Kokuten Style (2013) (0)
List of Characters (2013) (0)
Gathering the Higashiyama Circle (2013) (0)
Beyond Chikujōkai: Expanding Infl uences and New Encounters (2013) (0)
Artificial chromosomes. (1987) (0)
PRELIMINARY COMMUNICATION Open Access (2011) (0)
RNA-activated 2-AIpG monomer, 3h soaking (2018) (0)
RNA duplex with 2-MeImpG analogue bound-one binding site (2017) (0)
RNA 15mer duplex binding with PZG monomer (2016) (0)
Bakusen’s Early Life and Works: Towards a Rural Genre Painting (2013) (0)
embryonic development to death , including the discovery of the effects of shortening repetitive sequences of DNA , called telomeres , on the ends of chromosomes (2019) (0)
Synthesis of Model Protocells Reconstructing the Emergence of Cellular Life through the (2009) (0)
Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold (2007) (0)
Telomeres and Telomerase in Cellular Aging ( Senescence ) [ 1 ] (2019) (0)
Spontaneous division of model protocell membranes (2019) (0)
Out of a harsh and hostile earth (2010) (0)
RNA duplex, bound with TNA monomer (2020) (0)
RNA primer-template complex with guanosine dinucleotide ligand G(5')ppp(5')G (2017) (0)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme (1991) (0)
Author response: Non-enzymatic primer extension with strand displacement (2019) (0)
Fe2+ in Prebiotic Non-Enzymatic RNA Chemistry and Early Compartmentation (2017) (0)
Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes (2022) (0)
RNA-activated 2-AIpG monomer complex, 15 min soaking (2018) (0)
Thyroid iodoaminoacids in mice selected for high and low iodine uptake. (1970) (0)
6 Crystal structure studies of RNA molecules containing 2′–5′-linkages (2013) (0)
solution structure of a non-biological ATP-binding protein (2007) (0)
Photochemistry and the origin of life (Conference Presentation) (2019) (0)
RNA hairpin complex with guanosine dinucleotide ligand G(5')ppp(5')G (2018) (0)
NON-ENZYMATIC RNA REPLICATION AND THE ORIGIN OF LIFE (2012) (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue (2016) (0)
Virtual Circular Genome Model for Prebiotically Plausible Nonenzymatic RNA Replication (2022) (0)
RNA hairpin structure containing one TNA nucleotide as primer (2020) (0)
mRNA-display of DNA-binding helix-turn-helix protein (2004) (0)
RNA hairpin structure containing tetraloop/receptor motif (2018) (0)

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