Jack W. Szostak | Academic Influence

Jack W. Szostak's AcademicInfluence.com Rankings

Jack W. Szostak

Biology

#43

World Rank

#83

Historical Rank

#27

USA Rank

Molecular Biology

#30

World Rank

#30

Historical Rank

#21

USA Rank

Biochemistry

#34

World Rank

#46

Historical Rank

#23

USA Rank

Genetics

#31

World Rank

#52

Historical Rank

#21

USA Rank

biology Degrees

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Biology

Jack W. Szostak's Degrees

PhD Biochemistry Cornell University

Why Is Jack W. Szostak Influential?

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According to Wikipedia, Jack William Szostak is a Canadian American biologist of Polish British descent, Nobel Prize laureate, University Professor at the University of Chicago, former Professor of Genetics at Harvard Medical School, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston. Szostak has made significant contributions to the field of genetics. His achievement helped scientists to map the location of genes in mammals and to develop techniques for manipulating genes. His research findings in this area are also instrumental to the Human Genome Project. He was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Elizabeth Blackburn and Carol W. Greider, for the discovery of how chromosomes are protected by telomeres.

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Jack W. Szostak's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

In vitro selection of RNA molecules that bind specific ligands (1990) (7983)
The double-strand-break repair model for recombination (1983) (2386)
Yeast transformation: a model system for the study of recombination. (1981) (1253)
In vitro selection of functional nucleic acids. (1999) (1034)
A DNA aptamer that binds adenosine and ATP. (1995) (991)
RNA-peptide fusions for the in vitro selection of peptides and proteins. (1997) (932)
A mutant with a defect in telomere elongation leads to senescence in yeast (1989) (913)
Synthesizing life (2001) (856)
Synthesizing life : Paths to unforeseeable science & technology (2001) (829)
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging (2006) (815)
Isolation of new ribozymes from a large pool of random sequences [see comment]. (1993) (791)
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures (1992) (701)
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division (2003) (668)
Cloning yeast telomeres on linear plasmid vectors (1982) (585)
Template-directed synthesis of a genetic polymer in a model protocell (2008) (575)
Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site (1991) (525)
An RNA motif that binds ATP (1993) (523)
DNA sequences of telomeres maintained in yeast (1984) (514)
Double-strand breaks at an initiation site for meiotic gene conversion (1989) (505)
Functional proteins from a random-sequence library (2001) (490)
Genetic applications of yeast transformation with linear and gapped plasmids. (1983) (457)
Yeast recombination: the association between double-strand gap repair and crossing-over. (1983) (404)
Coupled Growth and Division of Model Protocell Membranes (2009) (391)
Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae (1980) (390)
Construction of artificial chromosomes in yeast (1983) (382)
Structurally complex and highly active RNA ligases derived from random RNA sequences. (1995) (378)
The Emergence of Competition Between Model Protocells (2004) (364)
Pedigree analysis of plasmid segregation in yeast (1983) (363)
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA (1991) (359)
A DNA metalloenzyme with DNA ligase activity (1995) (357)
The use of mRNA display to select high-affinity protein-binding peptides (2001) (354)
The guanosine binding site of the Tetrahymena ribozyme (1989) (298)
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae (1989) (280)
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene (2006) (269)
In vitro evolution of new ribozymes with polynucleotide kinase activity (1994) (254)
The eightfold path to non-enzymatic RNA replication (2012) (250)
One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. (2001) (243)
In vitro evolution of a self-alkylatlng ribozyme (1995) (240)
Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells (2013) (239)
Structural conventions for group I introns. (1987) (239)
Progress toward synthetic cells. (2014) (225)
Ribozyme-catalysed amino-acid transfer reactions (1996) (214)
RNA Catalysis in Model Protocell Vesicles (2005) (212)
Physical effects underlying the transition from primitive to modern cell membranes (2011) (208)
Competition between model protocells driven by an encapsulated catalyst. (2013) (207)
A kinetic study of the growth of fatty acid vesicles. (2004) (205)
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold (2007) (200)
RNA-catalysed synthesis of complementary-strand RNA (1989) (199)
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. (2018) (197)
Informational Complexity and Functional Activity of RNA Structures (2004) (192)
The origins of cellular life. (2010) (191)
Ribosomal synthesis of unnatural peptides. (2005) (191)
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. (1990) (185)
In vitro selection of RNA aptamers specific for cyanocobalamin. (1994) (182)
Chromosome segregation in mitosis and meiosis. (1985) (180)
RNA aptamers that bind flavin and nicotinamide redox cofactors. (1995) (178)
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors (2012) (178)
Replicating vesicles as models of primitive cell growth and division. (2004) (173)
Telomeric repeat from T. thermophila cross hybridizes with human telomeres (1988) (168)
In vitro evolution suggests multiple origins for the hammerhead ribozyme (2001) (167)
Thermostability of model protocell membranes (2008) (165)
ARD1 and NAT1 proteins form a complex that has N‐terminal acetyltransferase activity. (1992) (163)
Ribozyme-catalyzed tRNA aminoacylation (2000) (163)
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides (2007) (158)
Scanning the human proteome for calmodulin-binding proteins (2005) (151)
Isolation of high-affinity GTP aptamers from partially structured RNA libraries (2002) (149)
Protocells and RNA Self-Replication. (2018) (149)
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. (2004) (148)
In vitro genetics. (1992) (147)
Optimized synthesis of RNA-protein fusions for in vitro protein selection. (2000) (146)
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways (1985) (145)
Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents (1985) (144)
Transfer of yeast telomeres to linear plasmids by recombination (1984) (138)
Expanding roles for diverse physical phenomena during the origin of life. (2010) (136)
mRNA display: from basic principles to macrocycle drug discovery. (2014) (134)
Enzymatic aminoacylation of tRNA with unnatural amino acids. (2006) (132)
Stereospecific recognition of tryptophan agarose by in vitro selected RNA (1992) (131)
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns (1990) (130)
Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water (2010) (129)
Chromosome length controls mitotic chromosome segregation in yeast (1986) (128)
A Small Aptamer with Strong and Specific Recognition of the Triphosphate of ATP (2004) (128)
Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose (2005) (127)
Insertion of a genetic marker into the ribosomal DNA of yeast. (1979) (125)
Formation of Protocell-like Vesicles in a Thermal Diffusion Column (2009) (123)
TNA synthesis by DNA polymerases. (2003) (114)
Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. (2009) (113)
Selection of a ribozyme that functions as a superior template in a self-copying reaction. (1992) (113)
Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. (1996) (112)
An optimal degree of physical and chemical heterogeneity for the origin of life? (2011) (112)
Constructing high complexity synthetic libraries of long ORFs using in vitro selection. (2000) (111)
In vitro genetic analysis of the Tetrahymena self-splicing intron (1990) (110)
Isolation and characterization of fluorophore-binding RNA aptamers. (1998) (109)
Aptamers selected for higher-affinity binding are not more specific for the target ligand. (2006) (109)
Concentration-Driven Growth of Model Protocell Membranes (2012) (106)
Mineral Surface Directed Membrane Assembly (2007) (105)
Photochemically driven redox chemistry induces protocell membrane pearling and division (2012) (105)
A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae (1991) (105)
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides (2017) (105)
An alternative pathway for meiotic chromosome segregation in yeast. (1986) (105)
Functional information and the emergence of biocomplexity (2007) (103)
Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. (1996) (101)
Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication (2010) (100)
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. (1991) (100)
Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. (1990) (99)
Origins of life: Systems chemistry on early Earth (2009) (98)
Chance and necessity in the selection of nucleic acid catalysts. (1996) (97)
DNA polymerase-mediated DNA synthesis on a TNA template. (2003) (97)
The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life. (2017) (95)
Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides (2016) (94)
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus (1987) (91)
Reconstructing the emergence of cellular life through the synthesis of model protocells. (2009) (91)
Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot. (1998) (91)
Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. (1990) (89)
Isolation of a fluorophore-specific DNA aptamer with weak redox activity. (1998) (89)
RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. (1989) (88)
Enzymatic activity of the conserved core of a group I self-splicing intron (1986) (88)
Is there left-handed DNA at the ends of yeast chromosomes? (1983) (87)
High fidelity TNA synthesis by Therminator polymerase (2005) (84)
Ribosomal Synthesis of N-Methyl Peptides (2008) (84)
Fungal recombination (1985) (84)
Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. (2013) (84)
UV-light-driven prebiotic synthesis of iron-sulfur clusters. (2017) (84)
Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe (1987) (83)
A simple method for 3'-labeling of RNA. (1996) (82)
Stereochemical course of catalysis by the Tetrahymena ribozyme. (1989) (81)
Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers (2009) (81)
Kinetic Analysis of an Efficient DNA-Dependent TNA Polymerase (2005) (80)
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets (2014) (79)
An in Vitro Selection System for TNA (2005) (79)
Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae (1987) (79)
Cloning regulated yeast genes from a pool of lacZ fusions. (1983) (77)
Functional information: Molecular messages (2003) (77)
Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae (1988) (76)
Ribosomal synthesis of dehydroalanine-containing peptides. (2006) (76)
A simple physical mechanism enables homeostasis in primitive cells (2016) (73)
1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. (1994) (73)
Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. (2003) (73)
Multiple, Tandem Plasmid Integration in Saccharomyces cerevisiae (1983) (72)
In Vitro Selection of Specific Ligand‐binding Nucleic Acids (1992) (72)
Preparation of Large Monodisperse Vesicles (2009) (72)
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides (2017) (71)
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template (2007) (67)
Solution structure of an informationally complex high-affinity RNA aptamer to GTP. (2006) (66)
Attempts to Define Life Do Not Help to Understand the Origin of Life (2012) (66)
Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions (2014) (66)
Ribozymes: aiming at RNA replication and protein synthesis. (1996) (65)
A strategy for the generation of conditional mutations by protein destabilization. (1992) (62)
Identification of epitope‐like consensus motifs using mRNA display (2002) (62)
Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. (1995) (62)
Copying of Mixed-Sequence RNA Templates inside Model Protocells (2018) (61)
Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension (2015) (61)
Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer (2013) (61)
A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. (2003) (61)
Isolation of novel ribozymes that ligate AMP-activated RNA substrates. (1997) (59)
A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension (2016) (59)
Mutational analysis of conserved nucleotides in a self-splicing group I intron. (1990) (59)
Unusual metal ion catalysis in an acyl-transferase ribozyme. (1998) (57)
Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation (2017) (56)
20 In Vitro Selection of Functional RNA Sequences (1993) (56)
DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA (1981) (55)
In vitro selection of catalytic RNAs. (1994) (54)
Gene conversion adjacent to regions of double-strand break repair (1988) (54)
Multicomponent Assembly of Proposed DNA Precursors in Water (2012) (54)
In vitro genetic analysis: Selection and amplification of rare functional nucleic acids (1991) (54)
Hybridization with synthetic oligonucleotides. (1979) (53)
Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity (2011) (53)
N2′→P3′ Phosphoramidate Glycerol Nucleic Acid as a Potential Alternative Genetic System (2009) (53)
Collaboration between primitive cell membranes and soluble catalysts (2016) (53)
Isolation of a ribozyme with 5'-5' ligase activity. (1995) (52)
Introduction: Combinatorial Chemistry. (1997) (52)
The Origins of Nucleotides (2011) (52)
Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. (2018) (52)
In Vitro Selection of Functional Lantipeptides (2012) (51)
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. (2000) (47)
Structural and kinetic characterization of an acyl transferase ribozyme. (1998) (45)
Origin of life on earth. (2009) (44)
Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. (2008) (44)
Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization (2015) (44)
Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides (2015) (43)
Single-Molecule Imaging of an in Vitro-Evolved RNA Aptamer Reveals Homogeneous Ligand Binding Kinetics (2009) (42)
Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae (1986) (41)
Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension (2012) (40)
Structural insights into the effects of 2′-5′ linkages on the RNA duplex (2014) (40)
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA (2018) (40)
Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. (1995) (40)
Recombination between sequences in nonhomologous positions. (1983) (40)
Oligoarginine Peptides Slow Strand Annealing and Assist Nonenzymatic RNA Replication (2016) (39)
Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. (1993) (39)
Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs (2014) (39)
Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. (1997) (39)
In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. (1994) (39)
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes (2016) (38)
Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. (2004) (37)
Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. (1990) (37)
Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. (2006) (36)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme. (1991) (35)
Miniribozymes, small derivatives of the sunY intron, are catalytically active (1989) (35)
Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. (2006) (35)
Activated Ribonucleotides Undergo a Sugar Pucker Switch upon Binding to a Single-Stranded RNA Template (2012) (35)
Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA (1977) (34)
Artificial lantipeptides from in vitro translations. (2011) (34)
Bulk Self-Assembly of Giant, Unilamellar Vesicles. (2020) (31)
Meiotic recombination on artificial chromosomes in yeast. (1992) (31)
A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide (2017) (31)
The Free Energy Landscape of Pseudorotation in 3′–5′ and 2′–5′ Linked Nucleic Acids (2014) (30)
Replication and resolution of telomeres in yeast. (1983) (30)
Synthesis and Nonenzymatic Template-Directed Polymerization of 2′-Amino-2′-deoxythreose Nucleotides (2014) (29)
Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. (1991) (28)
The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. (2019) (26)
3 Protocells: Genetic Polymers Inside Membrane Vesicles (2006) (26)
Non-enzymatic primer extension with strand displacement (2019) (25)
Controlled Growth of Filamentous Fatty Acid Vesicles under Flow (2014) (25)
Template‐Directed Copying of RNA by Non‐enzymatic Ligation† (2020) (24)
Unusual Base-Pairing Interactions in Monomer–Template Complexes (2016) (24)
Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. (2019) (23)
Fungal recombination. (1985) (23)
Crystallographic observation of nonenzymatic RNA primer extension (2018) (23)
Shrink-wrap vesicles. (2005) (23)
Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells (2019) (23)
Single-molecule binding experiments on long time scales. (2010) (22)
Uncovering the Thermodynamics of Monomer Binding for RNA Replication (2015) (22)
Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex (2017) (22)
Enzymatic Primer-Extension with Glycerol-Nucleoside Triphosphates on DNA Templates (2009) (22)
Synthesis of α-l-Threofuranosyl Nucleoside Triphosphates (tNTPs) (2005) (21)
Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. (2019) (21)
A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides (2020) (20)
Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization (2007) (20)
Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide (2018) (19)
Generation of Functional RNAs from Inactive Oligonucleotide Complexes by Non-enzymatic Primer Extension (2014) (19)
Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms (2015) (19)
UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth (2019) (19)
Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation (2020) (19)
Roles of the 2 , um Gene Products in Stable Maintenance of the 2 iim Plasmid of Saccharomyces cerevisiae (18)
Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides (2015) (17)
Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (2008) (17)
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes (2017) (17)
Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom (2016) (17)
Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. (2011) (17)
DNA ends: just the beginning (Nobel lecture). (2010) (17)
Genetic dissection of an RNA enzyme. (1987) (17)
The virtual circular genome model for primordial RNA replication (2020) (17)
Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension (2018) (16)
Structure and evolutionary analysis of a non-biological ATP-binding protein. (2007) (16)
[18] Yeast vectors with negative selection (1983) (16)
In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates (2020) (16)
Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean–Archaean Earth (2018) (16)
Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying (2020) (16)
A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension (2017) (15)
Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II) (2018) (15)
A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2’-deoxynucleotides (2019) (15)
In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity (2006) (15)
Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis (2016) (14)
Lipid constituents of model protocell membranes. (2019) (13)
Ribozyme catalysis (1992) (13)
Exploding vesicles (2011) (13)
In vitro selection of RNA aptamers against a composite small molecule-protein surface (2005) (13)
Yeast vectors with negative selection. (1983) (13)
Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. (2016) (12)
Deep sequencing of non-enzymatic RNA primer extension (2020) (12)
Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. (1994) (12)
Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water (2011) (12)
The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis. (2021) (12)
2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. (2007) (11)
Transfer of Sequence Information and Replication of Diimine Duplexes (2019) (11)
Genetic and physical analyses of sister chromatid exchange in yeast meiosis (1991) (11)
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution (2017) (11)
How Did Life Begin? (2018) (10)
Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. (1994) (10)
The beginning of the ends (1989) (10)
Selection of Functional RNA and DNA Molecules from Randomized Sequences (1993) (10)
Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations (2015) (10)
Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. (2013) (10)
Mutations in a semiconserved region of the Tetrahymena intron (1991) (10)
Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension (2021) (10)
Conformational Analysis of DNA Repair Intermediates by Time-Resolved Fluorescence Spectroscopy (2009) (10)
Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying (2021) (9)
Preparation, Purification, and Use of Fatty Acid-containing Liposomes (2018) (9)
Large phenotypic enhancement of structured random RNA pools. (2019) (9)
Total chemical synthesis of a ribozyme derived from a group I intron. (1995) (9)
Evolution ex vivo (1993) (9)
Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage (2019) (9)
A rapid procedure for the construction of linear yeast plasmids. (1983) (9)
Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. (1990) (9)
Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates (2021) (9)
A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying. (2018) (9)
Preparation of fatty acid micelles. (2013) (8)
SEXUAL INDUCTION IN EUDORINA: EFFECTS OF LIGHT, NUTRIENTS, AND CONDITIONED MEDIUM 1 (1973) (8)
In search of the RNA world on Mars (2020) (8)
Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. (2017) (8)
Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage (2019) (7)
Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension (2017) (7)
Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. (2013) (7)
Structure and Activity of Ribozymes (1988) (7)
Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth (2021) (7)
Molecular biology: RNA gets a grip on translation (2002) (7)
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression. (2020) (7)
Selective labeling and detection of specific RNAs in an RNA mixture. (2003) (7)
Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase (2020) (6)
DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates (2019) (6)
Material for A Genomewide Search for Ribozymes Reveals an HDV-like Sequence in the Human CPEB 3 Gene (2006) (6)
Ray Wu, as remembered by a former student (2009) (6)
In vitro selection and directed evolution. (1997) (6)
The Origin of Life on Earth and the Design of Alternative Life Forms (2017) (6)
Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. (2016) (6)
Assembly of a functional ribozyme from short oligomers by enhanced non-enzymatic ligation (2019) (5)
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization (2020) (5)
In vitro Selection of Specific Ligand-Binding Nucleic Acids (1992) (5)
Not just Salk (2017) (5)
Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. (2016) (5)
Template-Free Assembly of Functional RNAs by Loop-Closing Ligation (2022) (5)
LIFE ON EARTH (2009) (5)
Structure-activity relationships in nonenzymatic template-directed RNA synthesis. (2021) (4)
Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides (2021) (4)
Erratum: Scanning the human proteome for calmodulin-binding proteins (Proceedings of the National Academy of Sciences of the United States of America (April 26, 2005) 102, 17 (5969-5974)) (2005) (4)
[17] Construction of specific chromosomal rearrangements in yeast (1983) (4)
Erratum: Competition between model protocells driven by an encapsulated catalyst (2013) (4)
Molecular diversity comes of age ! (1995) (4)
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry (2020) (4)
Bacterial carotenoids suppress Caenorhabditis elegans surveillance and defense of translational dysfunction (2020) (3)
Telomeres and artificial chromosomes in yeast (1984) (3)
Models of Protocellular Structure, Function and Evolution (2001) (3)
Construction of specific chromosomal rearrangements in yeast. (1983) (3)
Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides (2022) (3)
Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine (2019) (3)
Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions (2020) (3)
Telomerase: the beginning of the ends. (1989) (3)
The origins of life : a subject collection from Cold Spring Harbor perspectives in biology (2010) (3)
The ascent of molecules. (2013) (3)
Solid-Phase Synthesis of Sequence-Defined Informational Oligomers (2020) (2)
Chance and Necessity in the Selection of Nucleic Acid Catalysts (1996) (2)
‘Fair is Foul, and Foul is Fair’: Kyoto Nihonga, Anti-Bijin Portraiture and the Psychology of the Grotesque (2012) (2)
4 Towards non-enzymatic RNA replication (2013) (2)
Interpreting turbidity measurements for vesicle studies (2018) (2)
Functional RNAs exhibit tolerance for non-heritable 2 9 – 5 9 versus 3 9 – 5 9 backbone heterogeneity (2013) (2)
Retraction for Litovchick and Szostak, Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (2009) (2)
Introduction: Collectivism in Twentieth-Century Japanese Art with a Focus on Operational Aspects of Dantai (2013) (2)
Steps toward a Synthetic Protocell (2008) (2)
Models of the Protocellular Structures, Functions and Evolution (2000) (2)
The Mechanism of Nonenzymatic Template Copying with Imidazole‐Activated Nucleotides (2019) (2)
Chemical Synthesis of Oligoribonucleotides Containing 2‐Aminopurine: Substrates for the Investigation of Ribozyme Function. (1991) (2)
Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes (2022) (1)
RNA-catalyzed RNA Ligation within Prebiotically Plausible Model Protocells (2023) (1)
DNA ENDS: JUST THE BEGINNING (2009) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, dideoxy primer, 3'-amino-ddGTP (nGTP), and Ca2+ (2020) (1)
Deciphering nonenzymatic RNA polymerization through crystallography (2018) (1)
Two Paths to the Pure Land: The Niga-byakudō Theme and the Modernist Buddhist Art of Hada Teruo (2007) (1)
Painting Circles: Tsuchida Bakusen and Nihonga Collectives in Early Twentieth Century Japan (2013) (1)
5 Efficient and high-fidelity copying of an RNA-like model prebiotic system (2013) (1)
RNA-catalysed synthesis of complementary strand RNA (1989) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template and primer containing an N3'-> P5' linkage (2020) (1)
50 ideas to change science Part one Life and Earth (2010) (1)
Use Of Single-Molecule Imaging To Analyze The Distribution Of Binding Ability In RNA Aptamer Populations (2009) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template and 3'-amino primer (2020) (1)
On the origin of life. (2016) (1)
Chapter 7:Mammalian Self-Cleaving Ribozymes (2007) (1)
Author response: Crystallographic observation of nonenzymatic RNA primer extension (2018) (1)
Ribozymes. Evolution ex vivo. (1993) (1)
Designing Biomimetic, Dissipative Material Systems (2016) (1)
Experimental Tests of the Virtual Circular Genome Model for Nonenzymatic RNA Replication (2023) (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, 3'-amino primer, dGpNHpp analog, and Mn2+ (2020) (1)
Prebiotically Plausible Activation Chemistry Compatible with Nonenzymatic RNA Copying (2020) (1)
Self-assembly of model protocell membranes (2018) (1)
aptamer to GTP Solution structure of an informationally complex high-affinity RNA (2006) (1)
4 In Vitro Selection of Nucleic Acid Sequences that Bind Small Molecules (1996) (1)
Nonenzymatic loop-closing ligation generates RNA hairpins and is a template-free way to assemble functional RNAs (2021) (1)
Crystal Structures of RNA Duplexes Containing 2-thio-Uridine (2014) (0)
RNA hairpin structure containing one TNA nucleotide as template (2020) (0)
RNA hairpin structure containing 2-MeImpG monomer analogue and 2-MeImp-oligomer analogue (2018) (0)
notes on the contributors (1984) (0)
The Origins of Cellular Life service (2010) (0)
PRELIMINARY COMMUNICATION Open Access (2011) (0)
RNA hairpin structure containing 2-MeImpG analogue bound (2018) (0)
A simple method for 34-labeling of RNA (1996) (0)
NON-ENZYMATIC RNA REPLICATION AND THE ORIGIN OF LIFE (2012) (0)
Passive endocytosis in model protocells (2023) (0)
Rolesofthe2,umGeneProducts inStable Maintenance ofthe2iim Plasmid ofSaccharomyces cerevisiae (1987) (0)
solution structure of a non-biological ATP-binding protein (2007) (0)
Genetic andPhysical Analyses ofSister Chromatid Exchange inYeastMeiosis (1991) (0)
8 Using pseudorotation as a reaction coordinate in free energy simulations of nucleic acids (2013) (0)
GeneConversion Adjacent toRegions ofDouble-Strand BreakRepair (1988) (0)
How Did Life Begin? (2018) (0)
RNA-activated 2-AIpG monomer, 1.5h soaking (2018) (0)
Deep Phylogeny (2010) (0)
Nonenzymatic RNA-templated Synthesis of N3'→P5' Phosphoramidate DNA. (2020) (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue (2016) (0)
The Yeast ARD] Gene Product Is Required for Repression of Cryptic Mating-Type Information at the HML Locust (2014) (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue-3 binding sites (2016) (0)
Telomeres and Telomerase in Cellular Aging (Senescence) (2017) (0)
RNA-dGMP complex with Mg ion (2018) (0)
embryonic development to death , including the discovery of the effects of shortening repetitive sequences of DNA , called telomeres , on the ends of chromosomes (2019) (0)
Self-complimentary RNA 15mer binding with GMP monomers (2016) (0)
RNA hairpin, bound with TNA monomer (2020) (0)
Approaches to the selection of an RNA replicase (1994) (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites (2016) (0)
RNA-activated 2-AIpG monomer complex, 15 min soaking (2018) (0)
Author response: Non-enzymatic primer extension with strand displacement (2019) (0)
Molecular crowding facilitates ribozyme-catalyzed RNA assembly (2023) (0)
The Hayflick Limit (2017) (0)
Protocells Nonenzymatic Template-Directed RNA Synthesis Inside Model (2013) (0)
Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold (2007) (0)
RNA duplex, bound with TNA monomer (2020) (0)
RNA hairpin complex with guanosine dinucleotide ligand G(5')ppp(5')G (2018) (0)
Non-enzymatic primer extension with strand displacement 1 (0)
Cooperativity and Downstream Binding in RNA Replication (2016) (0)
High resolution RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G (2021) (0)
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets (2014) (0)
Artificial lantipeptides from in vitro translations w (2011) (0)
RNA-activated 2-AIpG monomer complex, 1h soaking (2018) (0)
RNA oligonucleotides with 3'-arabino guanosine co-crystallized with GMP (2020) (0)
Direct monitoring of the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization from gaps and overhangs (2023) (0)
Telomere DNA protects the chromosomes (2010) (0)
3'-deoxy modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G (2021) (0)
Making Modern Japanese-Style Painting: Kano Hōgai and the Search for Images by Chelsea Foxwell (review) (2019) (0)
Fe2+ in Prebiotic Non-Enzymatic RNA Chemistry and Early Compartmentation (2017) (0)
Thyroid iodoaminoacids in mice selected for high and low iodine uptake. (1970) (0)
Challenges, Changes, and Evolving Strategies at the Bunten (2013) (0)
Lipid exchange promotes fusion of model protocells (2023) (0)
RNA conformation and metal ion coordination in the nonenzymatic primer extension reaction center (2023) (0)
RNA hairpin structure containing tetraloop/receptor motif (2018) (0)
Immune Quiescence The Hedgehog Pathway Promotes (2012) (0)
7 Imperfect RNA synthesis via model prebiotic reactions and consequences for functional RNAs (2013) (0)
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML (1990) (0)
Main Manuscript for Passive endocytosis in protocells enables nutrient transport bypassing permeability limits (2022) (0)
Artificial chromosomes. (1987) (0)
Native RNA-10mer Structure: ccggcgccgg (2014) (0)
Synthesis of Model Protocells Reconstructing the Emergence of Cellular Life through the (2009) (0)
Views of Ryukyu:Paintings and Prints in the Hamilton Library Collection (2013) (0)
Spontaneous division of model protocell membranes (2019) (0)
List of Characters (2013) (0)
Gathering the Higashiyama Circle (2013) (0)
Picturing the Ryukyus: Other Images in the Sakamaki-Hawley Collection (2013) (0)
The Inaugural Kokuten Exhibition of 1918: Content and Contexts (2013) (0)
Abstract: The earth sciences: new resources for teachers (1995) (0)
“Art Is Something Born”: The Rise and Fall of the Kokuga Society (1918–28) and the Emergence of the Kokuten Style (2013) (0)
The Modernist Traditionalism of Isamu Noguchi and Hasegawa Saburo (2021) (0)
Hiatus, Expansion, and Collapse: The Kokuten’s Middle and Final Stages (2013) (0)
Documents Related to the Kokuga Sōsaku Kyōkai (2013) (0)
Beyond Chikujōkai: Expanding Infl uences and New Encounters (2013) (0)
Bakusen’s Early Life and Works: Towards a Rural Genre Painting (2013) (0)
Emergence of Primordial Enzymes from Mixtures of Random Peptides (2010) (0)
RNA hairpin structure containing 2-MeImp-oligo analogue (2018) (0)
Enhanced nonenzymatic RNA copying with in-situ activation of short oligonucleotides (2023) (0)
Artistic Flowering: The Second and Third Kokuten Exhibitions (2013) (0)
RNA-activated 2-AIpG monomer, 3h soaking (2018) (0)
RNA duplex bound with TNA 3'-3' imidazolium dimer (2020) (0)
RNA duplex with 2-MeImpG analogue bound-one binding site (2017) (0)
mRNA-display of DNA-binding helix-turn-helix protein (2004) (0)
RNA 10mer duplex with six 2'-5'-linkages (2014) (0)
RNA-imidazolium-bridged intermediate complex, 4h soaking (2018) (0)
RNA-activated 2-AIpG monomer complex, 5 min soaking (2018) (0)
50 ideas to change science: Artificial life (2010) (0)
Carol Widney Greider (1961-) (2019) (0)
RNA primer-template complex with guanosine dinucleotide p(5')G(3')p(5')G ligand (2017) (0)
Physical Models for Early Membrane Growth and Evolution (2013) (0)
Telomeres and Telomerase in Cellular Aging ( Senescence ) [ 1 ] (2019) (0)
Native 7mer-RNA duplex (2014) (0)
Template‐Directed Copying of RNA by Non‐enzymatic Ligation (2020) (0)
RNA-activated 2-AIpG monomer complex, 2h soaking (2018) (0)
A strategy forthegeneration ofconditional mutations byprotein destabilization (1992) (0)
In vitro selection of novel ligase ribozymes (1996) (0)
Origin of life on earth. (Cover story) (2009) (0)
RNA duplex containing UU mispair (2014) (0)
RNA primer-template complex with guanosine dinucleotide ligand G(5')ppp(5')G (2017) (0)
Structural Insights into the Evolution of a Non-Biological Protein (2007) (0)
Class I GTP aptamer (2006) (0)
Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides (2021) (0)
Miniribozymes, SmallDerivatives ofthesunYIntron, Are Catalytically Active (1989) (0)
RNA-activated 2-AIpG monomer complex, 30 min soaking (2018) (0)
RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue (2018) (0)
Out of a harsh and hostile earth (2010) (0)
RNA-dGMP complex with Sr ion (2018) (0)
Photochemistry and the origin of life (Conference Presentation) (2019) (0)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme (1991) (0)
6 Crystal structure studies of RNA molecules containing 2′–5′-linkages (2013) (0)
University of Groningen Single-molecule binding experiments on long time scales Elenko, (2010) (0)
RNA hairpin structure containing one TNA nucleotide as primer (2020) (0)
Virtual Circular Genome Model for Prebiotically Plausible Nonenzymatic RNA Replication (2022) (0)
RNA 15mer duplex binding with PZG monomer (2016) (0)
RNA-monomer complex containing pyrophosphate linkage (2019) (0)

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