Jack W. Szostak | Academic Influence

Why Is Jack W. Szostak Influential?

According to Wikipedia, Jack William Szostak is a Canadian American biologist of Polish British descent, Nobel Prize laureate, Professor of Genetics at Harvard Medical School, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston. Szostak has made significant contributions to the field of genetics. His achievement helped scientists to map the location of genes in mammals and to develop techniques for manipulating genes. His research findings in this area are also instrumental to the Human Genome Project. He was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Elizabeth Blackburn and Carol W. Greider, for the discovery of how chromosomes are protected by telomeres.

Jack W. Szostak's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

In vitro selection of RNA molecules that bind specific ligands (7448)
The double-strand-break repair model for recombination (2308)
Yeast transformation: a model system for the study of recombination. (1218)
In vitro selection of functional nucleic acids. (1009)
A DNA aptamer that binds adenosine and ATP. (941)
RNA-peptide fusions for the in vitro selection of peptides and proteins. (900)
A mutant with a defect in telomere elongation leads to senescence in yeast (891)
Synthesizing life : Paths to unforeseeable science & technology (831)
Isolation of new ribozymes from a large pool of random sequences [see comment]. (775)
Synthesizing life (773)
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging (769)
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures (658)
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division (636)
Cloning yeast telomeres on linear plasmid vectors (566)
Template-directed synthesis of a genetic polymer in a model protocell (557)
Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site (512)
An RNA motif that binds ATP (509)
DNA sequences of telomeres maintained in yeast (498)
Double-strand breaks at an initiation site for meiotic gene conversion (489)
Functional proteins from a random-sequence library (466)
Genetic applications of yeast transformation with linear and gapped plasmids. (440)
Yeast recombination: the association between double-strand gap repair and crossing-over. (384)
Construction of artificial chromosomes in yeast (377)
Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae (374)
Structurally complex and highly active RNA ligases derived from random RNA sequences. (362)
Coupled Growth and Division of Model Protocell Membranes (361)
Pedigree analysis of plasmid segregation in yeast (356)
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA (354)
The Emergence of Competition Between Model Protocells (347)
A DNA metalloenzyme with DNA ligase activity (341)
The use of mRNA display to select high-affinity protein-binding peptides (338)
The guanosine binding site of the Tetrahymena ribozyme (289)
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae (273)
In vitro evolution of new ribozymes with polynucleotide kinase activity (249)
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene (249)
The eightfold path to non-enzymatic RNA replication (237)
Structural conventions for group I introns. (236)
In vitro evolution of a self-alkylatlng ribozyme (234)
One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. (232)
Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells (223)
Ribozyme-catalysed amino-acid transfer reactions (214)
Progress toward synthetic cells. (210)
RNA Catalysis in Model Protocell Vesicles (204)
Physical effects underlying the transition from primitive to modern cell membranes (201)
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold (194)
Competition between model protocells driven by an encapsulated catalyst. (189)
RNA-catalysed synthesis of complementary-strand RNA (188)
A kinetic study of the growth of fatty acid vesicles. (187)
Ribosomal synthesis of unnatural peptides. (187)
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. (179)
Informational Complexity and Functional Activity of RNA Structures (179)
In vitro selection of RNA aptamers specific for cyanocobalamin. (176)
RNA aptamers that bind flavin and nicotinamide redox cofactors. (175)
Chromosome segregation in mitosis and meiosis. (175)
The origins of cellular life. (169)
Replicating vesicles as models of primitive cell growth and division. (166)
Telomeric repeat from T. thermophila cross hybridizes with human telomeres (163)
In vitro evolution suggests multiple origins for the hammerhead ribozyme (163)
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors (162)
Ribozyme-catalyzed tRNA aminoacylation (160)
ARD1 and NAT1 proteins form a complex that has N‐terminal acetyltransferase activity. (156)
Thermostability of model protocell membranes (156)
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides (147)
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. (147)
In vitro genetics. (144)
Optimized synthesis of RNA-protein fusions for in vitro protein selection. (143)
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways (137)
Isolation of high-affinity GTP aptamers from partially structured RNA libraries (137)
Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. (136)
Transfer of yeast telomeres to linear plasmids by recombination (135)
Stereospecific recognition of tryptophan agarose by in vitro selected RNA (130)
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns (128)
Expanding roles for diverse physical phenomena during the origin of life. (128)
Chromosome length controls mitotic chromosome segregation in yeast (127)
A Small Aptamer with Strong and Specific Recognition of the Triphosphate of ATP (125)
Enzymatic aminoacylation of tRNA with unnatural amino acids. (124)
mRNA display: from basic principles to macrocycle drug discovery. (122)
Insertion of a genetic marker into the ribosomal DNA of yeast. (121)
Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose (121)
Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water (120)
Protocells and RNA Self-Replication. (118)
TNA synthesis by DNA polymerases. (115)
Formation of Protocell-like Vesicles in a Thermal Diffusion Column (114)
An optimal degree of physical and chemical heterogeneity for the origin of life? (112)
Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. (111)
Constructing high complexity synthetic libraries of long ORFs using in vitro selection. (110)
Selection of a ribozyme that functions as a superior template in a self-copying reaction. (109)
A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. (106)
Isolation and characterization of fluorophore-binding RNA aptamers. (106)
Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. (106)
In vitro genetic analysis of the Tetrahymena self-splicing intron (105)
Aptamers selected for higher-affinity binding are not more specific for the target ligand. (105)
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides (104)
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. (104)
Mineral Surface Directed Membrane Assembly (103)
Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. (102)
Concentration-Driven Growth of Model Protocell Membranes (101)
Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. (99)
DNA polymerase-mediated DNA synthesis on a TNA template. (97)
Origins of life: Systems chemistry on early Earth (97)
Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication (97)
An alternative pathway for meiotic chromosome segregation in yeast. (97)
Photochemically driven redox chemistry induces protocell membrane pearling and division (96)
Functional information and the emergence of biocomplexity (94)
Chance and necessity in the selection of nucleic acid catalysts. (93)
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. (93)
Reconstructing the emergence of cellular life through the synthesis of model protocells. (89)
Isolation of a fluorophore-specific DNA aptamer with weak redox activity. (89)
Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. (88)
Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot. (88)
Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides (85)
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. (85)
Enzymatic activity of the conserved core of a group I self-splicing intron (85)
RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. (85)
Is there left-handed DNA at the ends of yeast chromosomes? (84)
The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life. (82)
Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers (82)
Ribosomal Synthesis of N-Methyl Peptides (81)
Stereochemical course of catalysis by the Tetrahymena ribozyme. (80)
High fidelity TNA synthesis by Therminator polymerase (79)
An in Vitro Selection System for TNA (78)
A simple method for 3'-labeling of RNA. (78)
Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. (78)
Kinetic Analysis of an Efficient DNA-Dependent TNA Polymerase (77)
Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. (77)
Scanning the human proteome for calmodulin-binding proteins (76)
Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. (75)
1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. (73)
Cloning regulated yeast genes from a pool of lacZ fusions. (73)
Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. (73)
Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. (72)
Functional information: Molecular messages (72)
Multiple, tandem plasmid integration in Saccharomyces cerevisiae. (71)
UV-light-driven prebiotic synthesis of iron-sulfur clusters. (69)
In Vitro Selection of Specific Ligand‐binding Nucleic Acids (69)
Preparation of Large Monodisperse Vesicles (68)
A simple physical mechanism enables homeostasis in primitive cells (67)
Fungal recombination (67)
Ribosomal synthesis of dehydroalanine-containing peptides. (67)
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets (65)
Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. (64)
Ribozymes: aiming at RNA replication and protein synthesis. (64)
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template (64)
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides (62)
Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer (62)
Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension (62)
Solution structure of an informationally complex high-affinity RNA aptamer to GTP. (60)
Identification of epitope‐like consensus motifs using mRNA display (60)
Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions (59)
A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension (59)
A strategy for the generation of conditional mutations by protein destabilization. (59)
A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. (58)
Mutational analysis of conserved nucleotides in a self-splicing group I intron. (58)
Isolation of novel ribozymes that ligate AMP-activated RNA substrates. (57)
Attempts to Define Life Do Not Help to Understand the Origin of Life (57)
Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation (57)
Unusual metal ion catalysis in an acyl-transferase ribozyme. (56)
20 In Vitro Selection of Functional RNA Sequences (56)
Copying of Mixed-Sequence RNA Templates inside Model Protocells (53)
Gene conversion adjacent to regions of double-strand break repair. (53)
In vitro selection of catalytic RNAs. (53)
In vitro genetic analysis: Selection and amplification of rare functional nucleic acids (53)
Multicomponent Assembly of Proposed DNA Precursors in Water (52)
Isolation of a ribozyme with 5'-5' ligase activity. (52)
Introduction: Combinatorial Chemistry. (51)
DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA (50)
In Vitro Selection of Functional Lantipeptides (50)
Collaboration between primitive cell membranes and soluble catalysts (50)
Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity (50)
N2′→P3′ Phosphoramidate Glycerol Nucleic Acid as a Potential Alternative Genetic System (49)
Origin of life on earth. (48)
Structural and kinetic characterization of an acyl transferase ribozyme. (45)
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. (45)
Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. (43)
Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization (43)
The Origins of Nucleotides (43)
Single-Molecule Imaging of an in Vitro-Evolved RNA Aptamer Reveals Homogeneous Ligand Binding Kinetics (41)
Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. (41)
Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. (40)
Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. (40)
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA (39)
In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. (38)
Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension (38)
Activated Ribonucleotides Undergo a Sugar Pucker Switch upon Binding to a Single-Stranded RNA Template (38)
Oligoarginine Peptides Slow Strand Annealing and Assist Nonenzymatic RNA Replication (37)
Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. (37)
Hybridization with synthetic oligonucleotides. (37)
Recombination between sequences in nonhomologous positions. (36)
Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs (36)
Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. (35)
Structural insights into the effects of 2′-5′ linkages on the RNA duplex (35)
Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. (35)
Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. (35)
Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides (35)
Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA (34)
Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. (34)
A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide (34)
Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. (33)
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes (32)
Fungal recombination. (31)
Artificial lantipeptides from in vitro translations. (31)
Meiotic recombination on artificial chromosomes in yeast. (29)
Replication and resolution of telomeres in yeast. (29)
3 Protocells: Genetic Polymers Inside Membrane Vesicles (28)
Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. (27)
The Free Energy Landscape of Pseudorotation in 3′–5′ and 2′–5′ Linked Nucleic Acids (26)
Unusual Base-Pairing Interactions in Monomer–Template Complexes (25)
Synthesis and Nonenzymatic Template-Directed Polymerization of 2′-Amino-2′-deoxythreose Nucleotides (24)
Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells (23)
Crystallographic observation of nonenzymatic RNA primer extension (23)
Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex (23)
Synthesis of α-l-Threofuranosyl Nucleoside Triphosphates (tNTPs) (21)
Shrink-wrap vesicles. (21)
Enzymatic Primer-Extension with Glycerol-Nucleoside Triphosphates on DNA Templates (21)
Single-molecule binding experiments on long time scales. (21)
Controlled Growth of Filamentous Fatty Acid Vesicles under Flow (20)
Generation of Functional RNAs from Inactive Oligonucleotide Complexes by Non-enzymatic Primer Extension (20)
Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization (20)
Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (18)
The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. (18)
Bulk Self-Assembly of Giant, Unilamellar Vesicles. (18)
Uncovering the Thermodynamics of Monomer Binding for RNA Replication (18)
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes (17)
Hybridization with synthetic oligonucleotides. (17)
Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms (17)
Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom (16)
Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide (16)
A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension (16)
[18] Yeast vectors with negative selection (16)
DNA ends: just the beginning (Nobel lecture). (16)
Template‐Directed Copying of RNA by Non‐enzymatic Ligation† (16)
Genetic dissection of an RNA enzyme. (16)
A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides (15)
Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis (15)
Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. (15)
Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. (15)
Structure and evolutionary analysis of a non-biological ATP-binding protein. (15)
Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth. (15)
In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity (14)
Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension (14)
In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates (13)
Roles of the 2 , um Gene Products in Stable Maintenance of the 2 iim Plasmid of Saccharomyces cerevisiae (13)
Exploding vesicles (13)
In vitro selection of RNA aptamers against a composite small molecule-protein surface (13)
Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II) (13)
Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides (12)
Material for A Genomewide Search for Ribozymes Reveals an HDV-like Sequence in the Human CPEB 3 Gene (12)
UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth. (12)
Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying. (11)
Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. (11)
Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. (11)
Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. (11)
2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. (11)
Yeast vectors with negative selection. (11)
Non-enzymatic primer extension with strand displacement (11)
Ribozyme catalysis (11)
Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. (10)
Conformational Analysis of DNA Repair Intermediates by Time-Resolved Fluorescence Spectroscopy (10)
The beginning of the ends (10)
A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2’-deoxynucleotides (10)
Selection of Functional RNA and DNA Molecules from Randomized Sequences (10)
Genetic and physical analyses of sister chromatid exchange in yeast meiosis. (10)
Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. (10)
Total chemical synthesis of a ribozyme derived from a group I intron. (9)
Evolution ex vivo (9)
Transfer of Sequence Information and Replication of Diimine Duplexes (9)
A rapid procedure for the construction of linear yeast plasmids. (9)
How Did Life Begin? (9)
Preparation, Purification, and Use of Fatty Acid-containing Liposomes (9)
Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage (9)
Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. (8)
Lipid constituents of model protocell membranes. (8)
The Virtual Circular Genome Model for Primordial RNA Replication. (8)
Mutations in a semiconserved region of the Tetrahymena intron (8)
Deep sequencing of non-enzymatic RNA primer extension (8)
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution (8)
Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. (8)
Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation. (8)
SEXUAL INDUCTION IN EUDORINA: EFFECTS OF LIGHT, NUTRIENTS, AND CONDITIONED MEDIUM 1 (8)
Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. (7)
A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying. (7)
Structure and Activity of Ribozymes (7)
Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. (7)
Non-enzymatic primer extension with strand displacement (7)
Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations (7)
Selective labeling and detection of specific RNAs in an RNA mixture. (7)
Preparation of fatty acid micelles. (7)
The Origins of Nucleotides (7)
Molecular biology: RNA gets a grip on translation (7)
DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates (7)
Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage (6)
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression. (6)
Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension (6)
LIFE ON EARTH (6)
Ray Wu, as remembered by a former student (6)
The Origin of Life on Earth and the Design of Alternative Life Forms (6)
In vitro selection and directed evolution. (6)
In vitro Selection of Specific Ligand-Binding Nucleic Acids (6)
Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase (5)
Assembly of a functional ribozyme from short oligomers by enhanced non-enzymatic ligation (5)
Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. (5)
Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine (4)
A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae (4)
Molecular diversity comes of age ! (4)
Erratum: Competition between model protocells driven by an encapsulated catalyst (4)
In search of the RNA world on Mars (4)
[17] Construction of specific chromosomal rearrangements in yeast (4)
A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying (4)
Erratum: Scanning the human proteome for calmodulin-binding proteins (Proceedings of the National Academy of Sciences of the United States of America (April 26, 2005) 102, 17 (5969-5974)) (4)
Not just Salk (4)
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry (4)
Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide (3)
Large phenotypic enhancement of structured random RNA pools. (3)
Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension (3)
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry. (3)
The ascent of molecules. (3)
Models of Protocellular Structure, Function and Evolution (3)
Bacterial carotenoids suppress Caenorhabditis elegans surveillance and defense of translational dysfunction (3)
The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis. (3)
Chemical Synthesis of Oligoribonucleotides Containing 2‐Aminopurine: Substrates for the Investigation of Ribozyme Function. (3)
The origins of life : a subject collection from Cold Spring Harbor perspectives in biology (3)
Telomeres and artificial chromosomes in yeast (3)
‘Fair is Foul, and Foul is Fair’: Kyoto Nihonga, Anti-Bijin Portraiture and the Psychology of the Grotesque (2)
Author response: Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides (2)
Models of the Protocellular Structures, Functions and Evolution (2)
Interpreting turbidity measurements for vesicle studies (2)
Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions. (2)
In search of the RNA world on Mars (2)
Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae (2)
Construction of specific chromosomal rearrangements in yeast. (2)
Colloquium Papers: Functional information and the emergence of biocomplexity (2)
Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension (2)
Steps toward a Synthetic Protocell (2)
Cloning regulated yeast genes from a pool of lacZ fusions. (2)
Structure-activity relationships in nonenzymatic template-directed RNA synthesis. (2)
Chapter 7:Mammalian Self-Cleaving Ribozymes (2)
Functional RNAs exhibit tolerance for non-heritable 2 9 – 5 9 versus 3 9 – 5 9 backbone heterogeneity (2)
Retraction for Litovchick and Szostak, Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (2)
Telomerase: the beginning of the ends. (2)
The Mechanism of Nonenzymatic Template Copying with Imidazole‐Activated Nucleotides (2)
4 Towards non-enzymatic RNA replication (2)
Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth (2)
Deciphering nonenzymatic RNA polymerization through crystallography (2)
aptamer to GTP Solution structure of an informationally complex high-affinity RNA (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template and primer containing an N3'-> P5' linkage (1)
Deep sequencing of nonenzymatic RNA primer extension (1)
4 In Vitro Selection of Nucleic Acid Sequences that Bind Small Molecules (1)
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization (1)
RNA-catalysed synthesis of complementary strand RNA (1)
Designing Biomimetic, Dissipative Material Systems (1)
Use Of Single-Molecule Imaging To Analyze The Distribution Of Binding Ability In RNA Aptamer Populations (1)
5 Efficient and high-fidelity copying of an RNA-like model prebiotic system (1)
Two Paths to the Pure Land: The Niga-byakudō Theme and the Modernist Buddhist Art of Hada Teruo (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, dideoxy primer, 3'-amino-ddGTP (nGTP), and Ca2+ (1)
Artificial chromosomes. (1)
50 ideas to change science Part one Life and Earth (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template and 3'-amino primer (1)
Ribozymes. Evolution ex vivo. (1)
Self-assembly of model protocell membranes (1)
DNA ENDS: JUST THE BEGINNING (1)
On the origin of life. (1)
Solid-Phase Synthesis of Sequence-Defined Informational Oligomers. (1)
Painting Circles: Tsuchida Bakusen and Nihonga Collectives in Early Twentieth Century Japan (1)
DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, 3'-amino primer, dGpNHpp analog, and Mn2+ (1)
Author response: Crystallographic observation of nonenzymatic RNA primer extension (1)
High resolution RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G (0)
50 ideas to change science: Artificial life (0)
Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae (0)
Genetic andPhysical Analyses ofSister Chromatid Exchange inYeastMeiosis (0)
RNA hairpin, bound with TNA monomer (0)
Synthesis of Model Protocells Reconstructing the Emergence of Cellular Life through the (0)
Meiotic recombination on artificial chromosomes in yeast. (0)
The Origin of Life on Earth and the Design of Alternative Life Forms (0)
RNA 15mer duplex binding with PZG monomer (0)
Photochemistry and the origin of life (Conference Presentation) (0)
Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue (0)
Physical Models for Early Membrane Growth and Evolution (0)
RNA hairpin complex with guanosine dinucleotide ligand G(5')ppp(5')G (0)
Out of a harsh and hostile earth (0)
Freeze-thaw Cycles Enable a Prebiotically Plausible and Continuous Pathway from Nucleotide Activation to Nonenzymatic RNA Copying (0)
Approaches to the selection of an RNA replicase (0)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme (0)
RNA hairpin structure containing 2-MeImpG analogue bound (0)
In vitro selection of novel ligase ribozymes (0)
Spontaneous division of model protocell membranes (0)
Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents (0)
mRNA-display of DNA-binding helix-turn-helix protein (0)
Nonenzymatic RNA-templated Synthesis of N3'→P5' Phosphoramidate DNA. (0)
Thyroid iodoaminoacids in mice selected for high and low iodine uptake. (0)
A simple method for 34-labeling of RNA (0)
RNA-activated 2-AIpG monomer complex, 1h soaking (0)
7 Imperfect RNA synthesis via model prebiotic reactions and consequences for functional RNAs (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites (0)
Author response: Non-enzymatic primer extension with strand displacement (0)
Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides. (0)
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization (0)
Native RNA-10mer Structure: ccggcgccgg (0)
RNA-activated 2-AIpG monomer, 1.5h soaking (0)
RNA duplex bound with TNA 3'-3' imidazolium dimer (0)
3'-deoxy modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G (0)
Template‐Directed Copying of RNA by Non‐enzymatic Ligation (0)
The Virtual Circular Genome Model for Primordial RNA Replication (0)
Chance and Necessity in the Selection of Nucleic Acid Catalysts (0)
RNA primer-template complex with 2-methylimidazole-activated monomer analogue-3 binding sites (0)
Protocells Nonenzymatic Template-Directed RNA Synthesis Inside Model (0)
RNA duplex containing UU mispair (0)
RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue (0)
Carol Widney Greider (1961-) (0)
The Origins of Cellular Life service (0)
Telomere DNA protects the chromosomes (0)
Miniribozymes, SmallDerivatives ofthesunYIntron, Are Catalytically Active (0)
RNA-monomer complex containing pyrophosphate linkage (0)
Rolesofthe2,umGeneProducts inStable Maintenance ofthe2iim Plasmid ofSaccharomyces cerevisiae (0)
RNA-activated 2-AIpG monomer complex, 5 min soaking (0)
RNA-imidazolium-bridged intermediate complex, 4h soaking (0)
Telomeres and Telomerase in Cellular Aging (Senescence) (0)
Class I GTP aptamer (0)
RNA-activated 2-AIpG monomer, 3h soaking (0)
Deep Phylogeny (0)
Crystallographic observation of nonenzymatic RNA primer extension (0)
Emergence of Primordial Enzymes from Mixtures of Random Peptides (0)
Cooperativity and Downstream Binding in RNA Replication (0)
RNA duplex with 2-MeImpG analogue bound-one binding site (0)
Beyond Chikujōkai: Expanding Infl uences and New Encounters (0)
Roles of the 2,um Gene Products in Stable Maintenance of the 2iim (0)
Kinetic Explanations for the Sequence Biases Observed in the Nonenzymatic Copying of RNA Templates (0)
Telomeres and Telomerase in Cellular Aging ( Senescence ) [ 1 ] (0)
Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold (0)
Nonenzymatic loop-closing ligation generates RNA hairpins and is a template-free way to assemble functional RNAs (0)
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML (0)
RNA-dGMP complex with Mg ion (0)
Origin of life on earth. (Cover story) (0)
Native 7mer-RNA duplex (0)
PRELIMINARY COMMUNICATION Open Access (0)
How Did Life Begin? (0)
8 Using pseudorotation as a reaction coordinate in free energy simulations of nucleic acids (0)
Miniribozymes, small derivatives of the sunY intron, are catalytically active (0)
embryonic development to death , including the discovery of the effects of shortening repetitive sequences of DNA , called telomeres , on the ends of chromosomes (0)
6 Crystal structure studies of RNA molecules containing 2′–5′-linkages (0)
RNA hairpin structure containing tetraloop/receptor motif (0)
RNA-activated 2-AIpG monomer complex, 15 min soaking (0)
RNA-dGMP complex with Sr ion (0)
RNA hairpin structure containing one TNA nucleotide as primer (0)
Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (0)
University of Groningen Single-molecule binding experiments on long time scales Elenko, (0)
Self-complimentary RNA 15mer binding with GMP monomers (0)
RNA-activated 2-AIpG monomer complex, 2h soaking (0)
Electronic Life-detection Instrument for Enceladus/Europa (ELIE) (0)
Artificial lantipeptides from in vitro translations w (0)
Gathering the Higashiyama Circle (0)
Immune Quiescence The Hedgehog Pathway Promotes (0)
Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates (0)
Structural Insights into the Evolution of a Non-Biological Protein (0)
NON-ENZYMATIC RNA REPLICATION AND THE ORIGIN OF LIFE (0)
Prebiotically Plausible Activation Chemistry Compatible with Nonenzymatic RNA Copying (0)
Abstract: The earth sciences: new resources for teachers (0)
Crystal Structures of RNA Duplexes Containing 2-thio-Uridine (0)
Non-enzymatic primer extension with strand displacement 1 (0)
solution structure of a non-biological ATP-binding protein (0)
Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe (0)
A strategy forthegeneration ofconditional mutations byprotein destabilization (0)
RNA hairpin structure containing one TNA nucleotide as template (0)
RNA-activated 2-AIpG monomer complex, 30 min soaking (0)
RNA hairpin structure containing 2-MeImpG monomer analogue and 2-MeImp-oligomer analogue (0)
Gene conversion adjacent to regions of double-strand break repair (0)
RNA primer-template complex with guanosine dinucleotide ligand G(5')ppp(5')G (0)
RNA primer-template complex with guanosine dinucleotide p(5')G(3')p(5')G ligand (0)
The Hayflick Limit (0)
Multiple, Tandem Plasmid Integration in Saccharomyces cerevisiae (0)
Genetic and physical analyses of sister chromatid exchange in yeast meiosis (0)
RNA duplex, bound with TNA monomer (0)
Gene Product Is Required for Repression of Cryptic Mating-Type Information at the HML Locust (0)
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus (0)
Non-enzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides (0)
Fe2+ in Prebiotic Non-Enzymatic RNA Chemistry and Early Compartmentation (0)
GeneConversion Adjacent toRegions ofDouble-Strand BreakRepair (0)
RNA hairpin structure containing 2-MeImp-oligo analogue (0)
RNA oligonucleotides with 3'-arabino guanosine co-crystallized with GMP (0)
Picturing the Ryukyus: Other Images in the Sakamaki-Hawley Collection (0)
Chelsea Foxwell’s Making Modern Japanese-Style Painting: Kano Hōgai and the Search for Images attempts to answer a seemingly simple ques- tion: by what process did Japanese painters in the early-to-mid-Meiji period (0)
Hiatus, Expansion, and Collapse: The Kokuten’s Middle and Final Stages (0)
Bakusen’s Early Life and Works: Towards a Rural Genre Painting (0)
Artistic Flowering: The Second and Third Kokuten Exhibitions (0)
The Modernist Traditionalism of Isamu Noguchi and Hasegawa Saburo (0)
“Art Is Something Born”: The Rise and Fall of the Kokuga Society (1918–28) and the Emergence of the Kokuten Style (0)
Making Modern Japanese-Style Painting: Kano Hōgai and the Search for Images by Chelsea Foxwell (review) (0)
Views of Ryukyu:Paintings and Prints in the Hamilton Library Collection (0)
List of Characters (0)
Documents Related to the Kokuga Sōsaku Kyōkai (0)
The Inaugural Kokuten Exhibition of 1918: Content and Contexts (0)
Challenges, Changes, and Evolving Strategies at the Bunten (0)
RNA 10mer duplex with six 2'-5'-linkages (0)
The Virtual Circular Genome Model for Primordial RNA Replication (0)

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