Jack W. Singer
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Engineering Computer Science
Jack W. Singer's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Computer Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Jack W. Singer's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanisms of action of arsenic trioxide. (2002) (961)
- One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. (1977) (926)
- Marrow transplantation for acute nonlymphoblastic leukemia in first remission. (1979) (628)
- Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer (1991) (491)
- Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment. (1983) (422)
- Monoclonal antibody 12-8 recognizes a 115-kd molecule present on both unipotent and multipotent hematopoietic colony-forming cells and their precursors (1986) (325)
- Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia. (1987) (320)
- Evidence for a multistep pathogenesis of a myelodysplastic syndrome. (1984) (307)
- Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration. (1985) (258)
- Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man (1982) (256)
- Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor (1993) (250)
- Marrow transplantation in thirty "untransfused" patients with severe aplastic anemia. (1980) (229)
- Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial (2018) (193)
- Paclitaxel poliglumex (XYOTAX, CT-2103): a macromolecular taxane. (2005) (189)
- Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial. (2017) (183)
- Acute nonlymphocytic leukemia: heterogeneity of stem cell origin (1981) (182)
- Phase III Trial Comparing Paclitaxel Poliglumex (CT-2103, PPX) in Combination with Carboplatin Versus Standard Paclitaxel and Carboplatin in the Treatment of PS 2 Patients with Chemotherapy-Naïve Advanced Non-small Cell Lung Cancer (2008) (175)
- Expression of the gene defect in X-linked agammaglobulinemia. (1986) (173)
- Location and distribution of difucoganglioside (VI3NeuAcV3III3Fuc2nLc6) in normal and tumor tissues defined by its monoclonal antibody FH6. (1985) (167)
- Acute nonlymphocytic leukemia: expression in cells restricted to granulocytic and monocytic differentiation. (1979) (155)
- Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer (2008) (152)
- TREATMENT OF CHRONIC GRANULOCYTIC LEUKAEMIA IN CHRONIC PHASE BY ALLOGENEIC MARROW TRANSPLANTATION (1982) (151)
- Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data. (2003) (144)
- Acute nonlymphocytic leukemia: heterogeneity of stem cell origin. (1981) (140)
- The L4F3 antigen is expressed by unipotent and multipotent colony-forming cells but not by their precursors. (1986) (132)
- Synthesis and in Vivo Antitumor Activity of Poly(l-glutamic acid) Conjugates of 20(S)-Camptothecin (2003) (129)
- Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane (2005) (128)
- Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo. (2001) (124)
- Treatment of adult acute lymphoblastic leukemia with allogeneic bone marrow transplantation. Multivariate analysis of factors affecting acute graft-versus-host disease, relapse, and relapse-free survival. (1991) (122)
- Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. (1997) (120)
- Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia. (1992) (120)
- Randomized Phase III Trial Comparing Single-Agent Paclitaxel Poliglumex (CT-2103, PPX) with Single-Agent Gemcitabine or Vinorelbine for the Treatment of PS 2 Patients with Chemotherapy-Naïve Advanced Non-small Cell Lung Cancer (2008) (118)
- Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II. (1979) (118)
- Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer–drug conjugate (2006) (118)
- Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. (2012) (111)
- Durable complete remission of acute nonlymphocytic leukemia associated with discontinuation of immunosuppression following relapse after allogeneic bone marrow transplantation. A case report of a probable graft-versus-leukemia effect. (1990) (108)
- Heterogeneity in human interleukin-3 receptors. A subclass that binds human granulocyte/macrophage colony stimulating factor. (1989) (108)
- Long-term follow-up of patients with invasive fungal disease who received adjunctive therapy with recombinant human macrophage colony-stimulating factor. (1993) (107)
- Graft‐versus‐host disease prevention by methotrexate combined with cyclosporin compared to methotrexate alone in patients given marrow grafts for severe aplastic anaemia: long‐term follow‐up of a controlled trial (1989) (102)
- Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice (1995) (100)
- Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. (1980) (99)
- In vitro and in vivo metabolism of paclitaxel poliglumex: identification of metabolites and active proteases (2007) (99)
- The cytoskeleton of stromal cells from human bone marrow cultures resembles that of cultured smooth muscle cells. (1990) (97)
- Effect of granulocyte-macrophage colony-stimulating factor and interleukin-3 on interleukin-8 production by human neutrophils and monocytes. (1993) (96)
- Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. (1994) (94)
- Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow. (1978) (93)
- Effect of peripheral blood lymphocytes from patients with aplastic anemia on granulocytic colony growth from HLA-matched and -mismatched marrows: effect of transfusion sensitization. (1978) (92)
- High-dose cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation in patients with lymphoid malignancies who have received dose-limiting radiation therapy. (1993) (89)
- Steroids and hematopoiesis I. The effect of steroids on in vitro erythroid colony growth: Structure/activity relationships (1976) (89)
- Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy (2018) (88)
- A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell. (1984) (86)
- Simian virus 40-transformed adherent cells from human long-term marrow cultures: cloned cell lines produce cells with stromal and hematopoietic characteristics. (1987) (85)
- Treatment of aplastic anemia by bone marrow transplantation in identical twins. (1980) (84)
- An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome. (1996) (84)
- Secondary malignancies after marrow transplantation. (1984) (82)
- Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression. (2004) (80)
- Use of alpha interferon for the treatment of relapse of chronic myelogenous leukemia in chronic phase after allogeneic bone marrow transplantation. (1992) (78)
- Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit. (1979) (78)
- A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation (1993) (75)
- Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. (2003) (73)
- Single-Agent Versus Combination Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer and a Performance Status of 2: Prognostic Factors and Treatment Selection Based on Two Large Randomized Clinical Trials (2009) (72)
- Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon. (1983) (71)
- Marrow transplantation from donors other than HLA-identical siblings. (1979) (70)
- SERUM REACTIVITY TO HUMAN T-CELL LEUKAEMIA/LYMPHOMA VIRUS TYPE I PROTEINS IN PATIENTS WITH LARGE GRANULAR LYMPHOCYTIC LEUKAEMIA (1987) (69)
- Allogeneic bone marrow transplantation for chronic granulocytic leukemia. (1981) (68)
- Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor (2016) (68)
- Immunosuppressive therapy of aplastic anemia: results of a prospective, randomized trial of antithymocyte globulin (ATG), methylprednisolone, and oxymetholone to ATG, very high-dose methylprednisolone, and oxymetholone. (1992) (67)
- Conjugation of Camptothecins to Poly‐(l‐Glutamic Acid) (2000) (67)
- Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. (1991) (67)
- CHRONIC LYMPHOCYTIC LEUKÆMIA: CLONAL ORIGIN IN A COMMITTED B-LYMPHOCYTE PROGENITOR (1978) (65)
- Restoration of nonclonal hematopoiesis in chronic myelogenous leukemia (CML) following a chemotherapy-induced loss of the Ph1 chromosome. (1980) (65)
- Anthracycline cardiotoxicity: Clinical and pathologic outcomes assessed by radionuclide ejection fraction (1980) (64)
- Human marrow stromal cells: response to interleukin-6 (IL-6) and control of IL-6 expression. (1989) (62)
- Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. (2003) (61)
- Humoral and cellular immune mechanisms of neutropenia in patients with Felty's syndrome. (1980) (60)
- Substrate specificity of lysophosphatidic acid acyltransferase beta -- evidence from membrane and whole cell assays. (2006) (60)
- 5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine. (1977) (59)
- One-hundred-ten patients with aplastic anemia (AA) treated by marrow transplantation in Seattle. (1978) (58)
- Phase I study of busulfan and cyclophosphamide in preparation for allogeneic marrow transplant for patients with multiple myeloma. (1992) (55)
- Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies (2016) (54)
- Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation (2018) (54)
- Steroids and hematopoiesis II. The effect of steroids on in vitro erythroid colony growth: Evidence for different target cells for different classes of steroids (1976) (53)
- The Novel Anthracenedione, Pixantrone, Lacks Redox Activity and Inhibits Doxorubicinol Formation in Human Myocardium: Insight to Explain the Cardiac Safety of Pixantrone in Doxorubicin-Treated Patients (2013) (53)
- CT‐1501R SELECTIVELY INHIBITS INDUCED INFLAMMATORY MONOKINES IN HUMAN WHOLE BLOOD EX VIVO (1994) (50)
- Paroxysmal nocturanal hemoglobinuria and marrow failure treated by infusion of marrow from an identical twin. (1976) (49)
- Comparison of pixantrone-based regimen (CPOP-R) with doxorubicin-based therapy (CHOP-R) for treatment of diffuse large B-cell lymphoma. (2013) (49)
- Chronic lymphocytosis with neutropenia: evidence for a novel, abnormal T-cell population associated with antibody-mediated neutrophil destruction. (1983) (48)
- Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-β inhibitors (2005) (48)
- Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines. (1996) (46)
- Lysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies. (2005) (46)
- Cultured marrow stromal cells express common acute lymphoblastic leukaemia antigen (CALLA): implications for marrow transplantation (1983) (45)
- Steroids and hematopoiesis. III. The response of granulocytic and erythroid colony-forming cells to steroids of different classes. (1976) (45)
- Time- and dose-dependent changes in ejection fraction determined by radionuclide angiography after anthracycline therapy. (1978) (43)
- A phase I and pharmacokinetic study of paclitaxel poliglumex and cisplatin in patients with advanced solid tumors (2009) (43)
- Results of the Persist-2 Phase 3 Study of Pacritinib (PAC) Versus Best Available Therapy (BAT), Including Ruxolitinib (RUX), in Patients (pts) with Myelofibrosis (MF) and Platelet Counts <100,000/µl (2016) (42)
- Regulation of cytokine and growth factor gene expression in human bone marrow stromal cells transformed with simian virus 40. (1990) (41)
- Sensitive detection of 5-methylcytosine and quantitation of the 5-methylcytosine/cytosine ratio in DNA by gas chromatography--mass spectrometry using multiple specific ion monitoring. (1979) (41)
- Phase I trial with recombinant human interleukin-3 in patients with lymphoma undergoing autologous bone marrow transplantation. (1993) (41)
- Lysophosphatidic acid acyltransferase-β: a novel target for induction of tumour cell apoptosis (2003) (40)
- Philadelphia chromosome (Ph1)-negative chronic myelogenous leukemia (CML): a clonal disease with origin in a multipotent stem cell. (1980) (39)
- Heterogeneity of B cell involvement in acute nonlymphocytic leukemia. (1985) (39)
- Phospholipase C δ-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells (2004) (38)
- Lysophosphatidic acid acyltransferase‐β (LPAAT‐β) is highly expressed in advanced ovarian cancer and is associated with aggressive histology and poor survival (2006) (36)
- Prevalence of clinically relevant bacteremia after upper gastrointestinal endoscopy in bone marrow transplant recipients. (1990) (35)
- DEGRADATION RATES OF VULGAXANTHINE I (1980) (35)
- Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes (2018) (33)
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures (2019) (31)
- Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia (2016) (31)
- Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors. (1989) (30)
- A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation. (1993) (30)
- Induction of Apoptosis Using Inhibitors of Lysophosphatidic Acid Acyltransferase-β and Anti-CD20 Monoclonal Antibodies for Treatment of Human Non-Hodgkin's Lymphomas (2005) (29)
- Evidence that oral pentoxifylline reverses acute renal dysfunction in bone marrow transplant recipients receiving amphotericin B and cyclosporine. Results of a pilot study. (1991) (29)
- Phase II study of tosedostat with cytarabine or decitabine in newly diagnosed older patients with acute myeloid leukaemia or high‐risk MDS (2016) (29)
- Coculture studies of 16 untransfused patients with aplastic anemia. (1979) (29)
- Effect of gender on outcome in two randomized phase III trials of paclitaxel poliglumex (PPX) in chemonaïve pts with advanced NSCLC and poor performance status (PS2). (2006) (28)
- Lisofylline inhibits transforming growth factor beta release and enhances trilineage hematopoietic recovery after 5-fluorouracil treatment in mice. (1996) (28)
- The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. (1990) (26)
- Chronic myelogenous leukemia: in vitro studies of hematopoietic regulation in a patient undergoing intensive chemotherapy. (1981) (26)
- Synthesis and in vivo antitumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin. (2003) (26)
- Monotherapy with pixantrone in histologically confirmed relapsed or refractory aggressive B‐cell non‐Hodgkin lymphoma: post‐hoc analyses from a phase III trial (2016) (26)
- Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta. (1994) (26)
- Expression of lysophosphatidic acid acyltransferase beta (LPAAT-β) in ovarian carcinoma: correlation with tumour grading and prognosis (2005) (25)
- Nontransformed colony-derived stromal cell lines from normal human marrows. I. Growth requirement and myelopoiesis supportive ability. (1995) (25)
- Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is highly expressed in advanced ovarian cancer and is associated with aggressive histology and poor survival. (2006) (25)
- Phase I/II study of pixantrone in combination with cyclophosphamide, vincristine, and prednisone in patients with relapsed aggressive non-Hodgkin lymphoma (2011) (24)
- Effect of 5-azacytidine on gene expression in marrow stromal cells (1989) (24)
- Toxic Epidermal Necrolysis Possibly Linked to Aztreonam in Bone Marrow Transplant Patients (1992) (23)
- Chronic myelogenous leukemia: Prolonged survival with spontaneous decline in the frequency of Ph1‐positive cells and subsequent development of mixed Ph1‐positive and Ph1‐negative blast crisis (1983) (23)
- Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib (2006) (23)
- Evidence for clonal development and stem cell origin of M7 megakaryocytic leukemia. (1988) (23)
- Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP. (1994) (21)
- Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non‐Hodgkin lymphoma (2011) (20)
- Serum-free estradiol (E2) levels are prognostic in men with chemotherapy-naive advanced non-small cell lung cancer (NSCLC) and performance status (PS) 2 (2007) (20)
- Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin. (2014) (20)
- Novel bis-platinum complexes endowed with an improved pharmacological profile. (2010) (19)
- Differences in the frequency of normal and clonal precursors of colony- forming cells in chronic myelogenous leukemia and acute myelogenous leukemia (1992) (19)
- Effect of Recombinant α-Interferon on the Expression of the bcr-abl Fusion Gene in Human Chronic Myelogenous Human Leukemia Cell Lines (1987) (19)
- Tracing Development and Cell Lineages in Human Hemopoietic Neoplasia (1985) (19)
- Trisomy of 1q in preleukaemia with progression to acute leukaemia. (2009) (18)
- Inhibitors of intracellular phosphatidic acid production: novel therapeutics with broad clinical applications (1994) (18)
- Lisofylline suppresses ex vivo release by murine spleen cells of hematopoietic inhibitors induced by cancer chemotherapeutic agents. (2000) (17)
- Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B‐cell non‐Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306) (2019) (17)
- Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta. (2004) (17)
- Effect of lysophosphatidic acid acyltransferase-β inhibition in acute leukemia (2006) (16)
- Stromal cells from human long-term marrow cultures, but not cultured marrow fibroblasts, phagocytose horse serum constituents: studies with a monoclonal antibody that reacts with a species-specific epitope common to multiple horse serum proteins. (1987) (16)
- Nature of remission in acute myeloid leukemia: more questions than answers. (1992) (16)
- Long-Term Follow-up of Patients With Invasive Fungal Disease Who Received Adjunctive Therapy With Recombinant Human Macrophage Colony-Stimulating Factor (2003) (16)
- Long-term follow-up of three controlled trials comparing cyclosporine versus methotrexate for graft-versus-host disease prevention in patients given marrow grafts for leukemia [letter] (1992) (16)
- Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. (2000) (15)
- Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis (1987) (15)
- Chronic Graft-versus-Host Disease: Pathogenesis, Diagnosis, Treatment, and Prognostic Factors (1988) (15)
- Recombinant tumor necrosis factor alpha and interleukin 1 alpha increase expression of c-abl protooncogene mRNA in cultured human marrow stromal cells. (1989) (14)
- Effect of methylxanthine derivatives on T cell activation. (1992) (14)
- Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis (2018) (14)
- Long-Term Response and Remission with Pixantrone in Patients with Relapsed or Refractory Aggressive Non-Hodgkin Lymphoma: Post-Hoc Analysis of the Multicenter, Open-Label, Randomized PIX301 Trial (2018) (13)
- Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. (1997) (13)
- Long-term cultures of human marrow cells. (1986) (13)
- Comprehensive Kinase Profile of Pacritinib, a Non-Myelosuppressive JAK2 Kinase Inhibitor in Phase 3 Development in Primary and Post ET/PV Myelofibrosis (2014) (13)
- "Clonal" remission in acute leukemia. (1984) (12)
- The effect of long-term marrow culture on the origin of colony-forming cells in acute myeloblastic leukemia: studies of two patients heterozygous for glucose-6-phosphate dehydrogenase. (1988) (12)
- Angioimmunoblastic lymphadenopathy with retinitis and drug related exacerbations. A clinicopathological case study (1979) (12)
- Localization of transfused neutrophils to site of infection during treatment with recombinant human granulocyte-macrophage colony- stimulating factor and pentoxifylline [letter] (1991) (12)
- Host origin of marrow stromal cells obtained from marrow transplant recipients and transformed in vitro by simian virus-40. (1988) (11)
- Viability of human marrow after long-term cryopreservation. (1980) (11)
- Marrow transplantation for severe aplastic anemia: the Seattle experience. (1984) (10)
- Recombinant granulocyte‐macrophage colony stimulating factor followed by immunosuppressive therapy for aplastic anaemia (1993) (10)
- A randomized placebo-controlled trial of lisofylline in HLA-identical, sibling-donor, allogeneic bone marrow transplant recipients. The Lisofylline Marrow Transplant Study Group. (2000) (10)
- The Cost-effectiveness of Pixantrone for Third/Fourth-line Treatment of Aggressive Non-Hodgkin's Lymphoma. (2016) (8)
- Iron storage and transport markers in Parkinson’s disease and MPTP-treated mice (1993) (8)
- Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta. (2005) (8)
- Use of interferon alfa-2a to treat hematologic relapse of chronic myelogenous leukemia after bone marrow transplantation. (1993) (8)
- Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia (1984) (7)
- Use of recombinant human granulocyte macrophage colony-stimulating factor to speed engraftment and treat graft failure following marrow transplantation in man. (1990) (7)
- Use of recombinant hematopoietic growth factors in bone marrow transplantation. (1993) (7)
- Time- and Dose‐Dependent Changes in Ejection Fraction After Anthracycline Therapy (1979) (7)
- Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer. (2016) (7)
- Synthesis, SAR, and Antitumor Properties of Diamino‐C,N‐diarylpyrimidine Positional Isomers: Inhibitors of Lysophosphatidic Acid Acyltransferase‐β. (2004) (7)
- Differential expression of collagenase by human fibroblasts and bone marrow stromal cells. (1994) (7)
- Comparison of two intravenous cyclosporine infusion schedules in marrow transplant recipients. (1988) (7)
- rhGM-CSF after allogeneic bone marrow transplantation from unrelated donors: a pilot study of cyclosporine and prednisone as graft-versus-host disease prophylaxis. (1993) (7)
- LACK of IRON Binding by Pixantrone IS ASSOCIATED with Reduced PRODUCTION of Reactive Oxygen SPECIES and Myoctye Cytotoxicity IN VITRO. (2009) (7)
- Sodium vanadate, a tyrosine phosphatase inhibitor, affects expression of hematopoietic growth factors and extracellular matrix RNAs in SV40-transformed human marrow stromal cells. (1992) (6)
- EFFECT OF GM-CSF ON CIRCULATING GRANULOCYTE-MONOCYTE PROGENITORS IN AUTOLOGOUS BONE MARROW TRANSPLANTATION (1989) (6)
- Poly- l -Glutamic Acid Anti-cancer Drug Conjugates (2010) (6)
- Clonal development of the acute leukemias. (1989) (6)
- Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. (2006) (6)
- Results of a Phase 3 Randomised Multicenter Study Comparing Pixantrone + Rituximab with Gemcitabine + Rituximab in Patients with Relapsed Aggressive B-Cell Non-Hodgkin Lymphoma Not Eligible for Stem Cell Transplantation (2018) (6)
- Transforming growth factor beta expression in human marrow stromal cells. (1991) (5)
- Effect of recombinant alpha-interferon on the expression of the bcr-abl fusion gene in human chronic myelogenous human leukemia cell lines. (1987) (5)
- Effects of marrow storage at 4 degrees C on the subsequent generation of long-term marrow cultures. (1985) (5)
- Targeting JAK2 By Gene Knockout or Pacritinib Treatment Reduces Gvhd and Xenograft Rejection By Promoting Induced Treg Differentiation (2015) (5)
- Pacritinib, a Dual FLT3/JAK2 Inhibitor, Reduces Irak-1 Signaling in Acute Myeloid Leukemia (2015) (5)
- Long-term follow-up of three controlled trials comparing cyclosporine versus methotrexate for graft-versus-host disease prevention in patients given marrow grafts for leukemia. (1992) (5)
- Activities derived from established human myeloid cell lines reverse the suppression of cell line colony formation by lactoferrin and transferrin. (1986) (4)
- P-939 XYOTAX™ (paclitaxel poliglumex, PPX): Pharmacokineticevidence for prolonged tumor exposure and reduced systemic exposure to paclitaxel (2005) (4)
- Pacritinib Targets IRAK1 and Shows Synergy with HDAC and BET Inhibitors in Acute Myeloid Leukemia (2016) (4)
- Cloning and sequencing of the human c-abl 3' untranslated region. (1990) (4)
- Helper (OKT4) T cells from human T cell colonies produce potent colony-stimulating activity. (1986) (4)
- Phase 3 Trial of Pixantrone Dimaleate Compared with Other Agents as Third-Line, Single-Agent Treatment of Relapsed Aggressive Non-Hodgkin Lymphoma (EXTEND): End of Study Results. (2010) (4)
- Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer (1994) (4)
- In vitro marrow culture techniques in aplastic anaemia and related disorders. (1978) (4)
- Clonal remission in childhood acute myeloid leukemia is an infrequent event. (1993) (4)
- Clonal remissions in acute nonlymphocytic leukemia: implications for curability. (1991) (3)
- Phase III Trial of Pixantrone Dimaleate Compared with Other Agents as Third-Line, Single-Agent Treatment of Relapsed Aggressive Non-Hodgkin's Lymphoma (EXTEND): Results From the Treatment and Follow-up Periods. (2009) (3)
- Relationship of JAK2V617F Allelic Burden (AB) to Demographics, Disease Characteristics, and Response to Therapy in Persist-1, a Randomized Phase III Study of Pacritinib (PAC) Versus Best Available Therapy (BAT) in Patients (pts) with Primary and Secondary Myelofibrosis (MF) (2016) (3)
- Serologic surveillance for evidence of deep disseminating fungal infections in bone marrow transplantation recipients. (1988) (3)
- Biodistribution of paclitaxel poliglumex (PPX) in lung: Analysis of gender-related alterations in a preclinical model. (2006) (3)
- Comparative biomarker profiles of pacritinib, momelotinib, pexidartinib, and ruxolitinib using BioMAP Diversity PLUS panel (2016) (3)
- CPOP-R Versus CHOP-R as First-line Therapy for Diffuse Large B-cell Lymphoma (DLBCL): A Phase 2, Randomized, Open-label, Multicenter Study (2011) (3)
- Hematopoietic growth factors in marrow transplantation and radiation injury. (1990) (3)
- Long-term follow-up of 103 patients who received recombinant human granulocyte-macrophage colony-stimulating factor after unrelated donor bone marrow transplantation. (1993) (3)
- Localization of transfused neutrophils to site of infection during treatment with recombinant human granulocyte-macrophage colony-stimulating factor and pentoxifylline. (1991) (2)
- Phase III Trial Comparing Paclitaxel Poliglumex (CT-2103, PPX) in Combination with Carboplatin Versus Standard Paclitaxel and Carboplatin in the Treatment of PS 2 Patients with Chemotherapy-Naı¨ve Advanced Non-small Cell Lung Cancer (2008) (2)
- Different types of endotoxin-induced release of colony stimulating factors by adherent leucocytes in the presence of fresh and heat-inactivated autologous serum. (2009) (2)
- 633 POSTER Effect of estrogen on cathepsin B activity and antitumor efficacy of Paclitaxel Poliglumex in human tumor xenografts (2006) (2)
- Engraftment of HLA Identical Marrow in Treatment of Severe Aplastic Anemia: Results of 110 Consecutive Transplants (1978) (2)
- Procoagulant inhibitory properties of paclitaxel poliglumex (2010) (2)
- Perioperative treatment with phosphatidic acid inhibitor (Lisofylline leads to prolonged survival of hearts in the guinea pig to rat xenotransplant model. (1996) (2)
- Metabolism of poly-l-glutamic acid (PG) paclitaxel (CT-2103); characterization of metabolites generated through proteolysis by lysosomal cathepsin B (2002) (2)
- forming cells but not by their precursors The L4F3 antigen is expressed by unipotent and multipotent colony (2011) (2)
- Serum Colony Stimulating Factor: A Marker for Graft-versus-Host Disease in Humans (1977) (2)
- A Phase II Study Of Tosedostat (TST) In Combination With Either Cytarabine Or Decitabine In Newly Diagnosed Older Patients With Acute Myeloid Leukemia (AML) Or High-Risk Myelodysplastic Syndrome (MDS) (2013) (2)
- Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells (2018) (2)
- 637 POSTER Paclitaxel poliglumex cellular uptake by normal tissues and human tumor xenograft: an IHC study in nude mice (2006) (2)
- B2-04: Single agent versus combination therapy in advanced NSCLC patients with performance status 2: Results from a regression analysis of STELLAR 3 and 4 (2007) (2)
- Human myelo proliferative disorders clonal origin in pluripotent stem cells (1978) (1)
- Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis (2018) (1)
- Cardiac toxicity of arsenic trioxide. (2001) (1)
- Models to Predict Response to JAK-inhibitor Therapy in Patients with Myelofibrosis (2017) (1)
- Influence of infusion duration on the efficacy and toxicity of intravenous cyclosporine in bone marrow transplant patients. (1988) (1)
- Abstract 3576: Pixantrone is chemically and mechanistically related to mitoxantrone (Mito) and doxorubicin (Dox) but lacks their iron binding properties and myocyte toxicity in vitro (2010) (1)
- Novel bisplatinum complexes characterized by an improved in vitro plasma protein binding and in vivo efficacy on xenograft models (2007) (1)
- Role of colony-stimulating factors in bone marrow transplantation. (1992) (1)
- Abstract CT159: Investigation of the absorption, metabolism, excretion, and mass balance of [14C]-pacritinib in healthy subjects: a phase I study (2016) (1)
- Non-Small Cell Lung Cancer: Does Estrogen Affect Outcome? (2007) (1)
- Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. (1997) (1)
- The Use of Genetic Markers in Studies of Myeloid Neoplasia. (1990) (1)
- Targeting Aminopeptidases by Tosedostat (TST) (CHR2797), Alone and with LBH589, Induces Significant Cytotoxicity Against Human Multiple Myeloma (MM) Cells (2012) (1)
- Marrow Stromal Cells, Hematopoietic Growth Factors and Extracellular Matrix Proteins (1990) (1)
- Studies with human long-term marrow cultures. (1984) (1)
- Mechanisms of Action of Arsenic Trioxide Updated (2002) (1)
- Marrow Transplantation for Severe Aplastic Anemia (2020) (1)
- Pixantrone Dimaleate (PIX) and Comparators In the Treatment of Relapsed Aggressive Non-Hodgkin Lymphoma (aNHL): An Analysis of Response and Survival by Gender and Age (2010) (0)
- BBR 3576 a 9-aza-anthrapyrazole endowed with high antitumor activity on prostate carcinoma models (2007) (0)
- Monoclonal antibody treatment of peripheral blood cells from some patients with acute non lymphocytic leukemia results in generation of normal colony forming unit granulocyte macrophage in long term culture (1985) (0)
- transplantation regimen-related toxicities in patients undergoing allogeneic marrow A randomized controlled trial of pentoxifylline for the prevention of (2011) (0)
- 643 POSTER Energy dependent uptake of paclitaxel poliglumex by human NSCLC tumor and murine macrophage-like cell lines (2006) (0)
- Diamino‐C,N‐diarylpyridine Positional Isomers as Inhibitors of Lysophosphatidic Acid Acyltransferase‐β. (2006) (0)
- Alive in continuous remission Alive after relapse Transplant deaths ’ Causes of Death Relapse Graft failure and infection Without GVHD CMV pneumonia Other infection Hemorrhage VOD of liver CMV pneumonia Other infection Pulmonary failure With chronic GVHD Infection CMV pneumonia (2003) (0)
- Phase 1-11 Trial of Pentoxifylline for the Prevention of Transplant-Related Toxicities Following Bone Marrow Transplantation (2003) (0)
- LPAAT-B is a prognostic and therapeutic target in epithelial ovarian cancer (2004) (0)
- Simian Virus 40Transformed 40Transformed 40Transformed Adherent Cells From Human Long-term Marrow Cultures : Cloned Cell Lines Produce Cells With Stromal and Hematopoietic Characteristics (2005) (0)
- Radiopharmaceutical reimbursement rates. (2008) (0)
- Recombinant tumor necrosis factor a and interleukin la increase expression of c-abl protooncogene mRNA in cultured human marrow stromal cells (0)
- Studies on Untransfused Patients with Aplastic Anemia (AA) (1979) (0)
- Single-agent compared to combination first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) and a performance status (PS) of 2 (2016) (0)
- Phase II Clinical Study of the Clinical Efficacy and Safety of Tosedostat in Patients with Myelodysplastic Syndromes (MDS) after Failure of Hypomethylating Agent-Based Therapy (2017) (0)
- The use of recombinant human granulocyte macrophage colony-stimulating factor in autologous bone marrow transplantation. (1991) (0)
- Pharmacokinetics and Safety of Pacritinib in Patients with Hepatic Impairment and Healthy Volunteers (2016) (0)
- Pixantrone (PIX) Inhibition of Doxorubicinol (DOXOL) Formation in Human Myocardium: Implications for Cardiac Safety in Non-Hodgkin Lymphoma (NHL) Patients with Prior Anthracycline Treatment (2011) (0)
- P3-019: Serum Cathepsin B (CB) is prognostic and may predict response to therapy in chemotherapy-naive PS2 advanced NSCLC patients treated on two concurrent phase III trials of paclitaxel poliglumex (PPX) vs control treatments (STELLAR 3 and 4) (2007) (0)
- Stimulation of release of hematopoietic inhibitors by hydrophobic or amphipathic chemotherapeutic agents Inhibition by lisofylline (1994) (0)
- Abstract 4675: Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal growth factor receptor mutation-positive non-small cell lung cancer (2016) (0)
- A Randomized Phase II Study of Tosedostat in Combination with Either Cytarabine or Decitabine in Newly Diagnosed Older Patients with Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome (2014) (0)
- Selective Inhibition of Lysophosphatidic Acid Acyltransferase-β by CT32228 Inhibits MAPK and Enhances the Antileukemic Activity of Imatinib in BCR-ABL Expressing Cell Lines Resistant to Imatinib. (2005) (0)
- body irradiation, and allogeneic marrow transplantation One hundred patients with acute leukemia treated by chemotherapy, total (2011) (0)
- Molecular Characterization of PS-341 (bortezomib) Resistance: Implications for Overcoming Resistance Using Lysophosphatidic Acid Acyltransferase (LPAAT)-β Inhibitors. (2004) (0)
- Co-culture studies in transfused and untransfused patients with aplastic anemia. (1979) (0)
- Radioresistance oftheEnhancing Effect ofCells fromCarrier-Immunized Mice inanInVitro PrimaryImmuneResponse (1971) (0)
- Chronic Myelogenous Leukemia IN VITRO STUDIES OF HEMATOPOIETIC REGULATION IN A PATIENT UNDERGOINGINTENSIVE CHEMOTHERAPY (2013) (0)
- An Integrated Efficacy and Safety Analysis of Phase 1/2 Studies of Tosedostat, a Novel Aminopeptidase Inhibitor, as Monotherapy for Hematological Malignancies (2014) (0)
- Serum cathepsin B (CB) levels are prognostic in chemotherapy-naive patients (pts) with advanced non-small cell lung cancer (NSCLC) and performance status (PS) of 2 (2007) (0)
- IL-6 expression Human marrow stromal cells: response to interleukin-6 (IL-6) and control of (2011) (0)
- 645 POSTER Effect of estrogen on outcome in two randomized phase III studies of paclitaxel poliglumex (PPX) in advanced non-small cell lung cancer (NSCLC) (2006) (0)
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What Schools Are Affiliated With Jack W. Singer?
Jack W. Singer is affiliated with the following schools:
