Jacob Glanville
American computational immunoengineer and businessperson
Jacob Glanville's AcademicInfluence.com Rankings
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Business Biology
Jacob Glanville's Degrees
- PhD Immunology Stanford University
- Masters Business Administration Stanford University
- Bachelors Bioengineering University of California, Berkeley
Why Is Jacob Glanville Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jacob Eli Gunn Glanville is an American computational immunoengineer and businessperson. He is co-founder and chief executive officer of the start-up company Distributed Bio and its spin-out, Centivax. Glanville was featured in the documentary series Pandemic: How to Prevent an Outbreak. Glanville was born in The Dalles, Oregon and raised in Guatemala to American expatriate parents. His mother is an artist and his father an inn keeper. In 2007, Glanville graduated from University of California, Berkeley where he studied Genetics, Genomics, and Development in the Molecular and Cellular Biology program and conducted research in the Glenys Thomsom HLA population genetics laboratory and Kimmen Sjolander Berkeley Phylogenomics group. In 2008, he joined Pfizer and was promoted to staff scientist four years later. In 2012, Glanville founded Distributed Bio and became the first Computational and Systems Immunology Ph.D. candidate at Stanford University. He completed his doctorate in 2017. His doctoral advisors were Scott D. Boyd and Mark M. Davis. Glanville's dissertation was titled Reading the adaptive receptor repertoires. Microbiologist Sarah Ives is his research co-lead at Distributed Bio on the influenza project featured in Pandemic: How to Prevent an Outbreak.
Jacob Glanville's Published Works
Published Works
- Identifying specificity groups in the T cell receptor repertoire (2017) (606)
- Diversity and clonal selection in the human T-cell repertoire (2014) (545)
- Linking T-cell receptor sequence to functional phenotype at the single-cell level (2014) (438)
- Deconstructing the Peptide-MHC Specificity of T Cell Recognition (2014) (431)
- Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire (2009) (393)
- A catalog of the mouse gut metagenome (2015) (383)
- Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. (2014) (214)
- B cell exchange across the blood-brain barrier in multiple sclerosis. (2012) (204)
- Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease (2013) (169)
- Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation (2011) (165)
- Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study (2021) (161)
- IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity (2016) (136)
- Human B-cell isotype switching origins of IgE. (2016) (111)
- Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets (2016) (104)
- Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein (2017) (94)
- The Individual and Population Genetics of Antibody Immunity (2017) (90)
- Synthetic antibodies designed on natural sequence landscapes. (2011) (83)
- Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens. (2017) (74)
- When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions (2018) (63)
- T Cell–Dependent Affinity Maturation and Innate Immune Pathways Differentially Drive Autoreactive B Cell Responses in Rheumatoid Arthritis (2018) (58)
- Disruption of Adaptive Immunity Enhances Disease in SARS-CoV-2-Infected Syrian Hamsters (2020) (52)
- Deep sequencing in library selection projects: what insight does it bring? (2015) (49)
- Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential. (2013) (42)
- A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals (2015) (38)
- Comment on “A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data” (2017) (35)
- Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy. (2016) (33)
- Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire (2016) (31)
- Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers (2021) (30)
- The Restricted DH Gene Reading Frame Usage in the Expressed Human Antibody Repertoire Is Selected Based upon its Amino Acid Content (2013) (29)
- A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation (2015) (24)
- The antibody mining toolbox (2013) (22)
- Codon-Precise, Synthetic, Antibody Fragment Libraries Built Using Automated Hexamer Codon Additions and Validated through Next Generation Sequencing (2015) (17)
- Multivalency transforms SARS-CoV-2 antibodies into broad and ultrapotent neutralizers (2020) (16)
- Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions (2013) (15)
- High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance (2017) (14)
- Erratum: IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity (2016) (10)
- Converging evolution leads to near maximal junction diversity through parallel mechanisms in B and T cell receptors (2017) (8)
- Estimate of within population incremental selection through branch imbalance in lineage trees (2014) (6)
- A new clustering method identifies multiple sclerosis‐specific T‐cell receptors (2021) (6)
- Deep profiling of single T cell receptor repertoire and phenotype with targeted RNA-seq (TECH2P.927) (2015) (5)
- Comparative analysis of the feline immunoglobulin repertoire. (2017) (5)
- A general solution to broad-spectrum vaccine design for rapidly mutating viruses (2020) (5)
- Correction: Corrigendum: Linking T-cell receptor sequence to functional phenotype at the single-cell level (2015) (4)
- Editorial: Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development (2020) (4)
- Erratum: Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E10438–E10445) DOI: 10.1073/pnas.1715812114) (2018) (2)
- Antibody reproducibility challenges: the solution lies in the sequence (2016) (1)
- Abstract 4895: A cancer stem cell instigator pathway revealed by transcriptomics, stem cell mutagenesis, and in-vivo tumor initiation. (2013) (0)
- A mouse fecal microbial gene catalogue established by Illumina-based sequencing (2012) (0)
- Bypassing Tetramers: Convergent Anti-Epstein Barr Virus (EBV) T Cell Repertoires Allow Specificities to Be Read From Primary Sequence.: Abstract# 1329 (2014) (0)
- Formation and function of basic body tissues (1971) (0)
- Abstract 3966: Mining the cancer immuno-responsome: The identification of functional antitumor antibodies from patients receiving checkpoint inhibitors (2018) (0)
- Abstract 922: End-to-end discovery to support the development of safe and efficacious engineered cell therapies (2021) (0)
- Erratum: Bring out your dead (2015) (0)
- Abstract 523: Advanced engineering using CAR-T display libraries: Ultra-high throughput functional screen (2020) (0)
- Computational and Systems Immunology: A Student's Perspective. (2019) (0)
- Basic Materials and Workmanship (1994) (0)
- Amendments: Author Correction: A catalog of the mouse gut metagenome (2019) (0)
- Abstract 1550: Bruteforcing immune oncology discovery with computational immuno-engineering (2019) (0)
- Improving Antibody Discovery and Selection Techniques Moderator: David King, Chief Scientific Officer, AnaptysBio 8:00 Isolation and Deep Sequencing of HIV-1 Neutralizing Antibodies (2012) (0)
- Acid Content Repertoire Is Selected Based upon its Amino Usage in the Expressed Human Antibody Gene Reading Frame H The Restricted D (2013) (0)
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