Jacobijn Gussekloo

Jacobijn Gussekloo's AcademicInfluence.com Rankings

Jacobijn Gussekloo

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#8291

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Philosophy

Jacobijn Gussekloo's Degrees

Bachelors Biology University of Amsterdam
Masters Biomedical Sciences Leiden University
PhD Gerontology Utrecht University

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Jacobijn Gussekloo's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Subclinical hypothyroidism and the risk of coronary heart disease and mortality. (2010) (968)
Thyroid status, disability and cognitive function, and survival in old age. (2004) (826)
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. (2010) (500)
Successful aging in the oldest old: Who can be characterized as successfully aged? (2001) (479)
Meta-analysis: Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality (2008) (470)
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. (2012) (451)
Subclinical Thyroid Dysfunction and the Risk of Heart Failure Events: An Individual Participant Data Analysis From 6 Prospective Cohorts (2012) (379)
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study (2010) (339)
Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study (2009) (332)
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study. (2002) (327)
Accuracy of the 15‐item geriatric depression scale (GDS‐15) in a community sample of the oldest old (2003) (327)
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population‐based study (2005) (321)
Subclinical thyroid dysfunction and fracture risk: a meta-analysis. (2015) (256)
Integrated disease management interventions for patients with chronic obstructive pulmonary disease. (2013) (249)
A high response is not essential to prevent selection bias: results from the Leiden 85-plus study. (2002) (227)
Temporal relation between depression and cognitive impairment in old age: prospective population based study (2004) (227)
High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age. (2003) (206)
Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age (2007) (205)
The metabolic syndrome is associated with decelerated cognitive decline in the oldest old (2007) (195)
Prevalence, correlates and recognition of depression in the oldest old: the Leiden 85-plus study. (2004) (188)
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism (2017) (180)
Inflammation and Stroke: The Leiden 85-Plus Study (2002) (180)
In a population-based prospective study, no association between high blood pressure and mortality after age 85 years (2006) (179)
Association between high‐density lipoprotein and cognitive impairment in the oldest old (2002) (177)
Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study. (2005) (175)
Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. (2012) (174)
Walking and Talking as Predictors of Falls in the General Population: The Leiden 85‐Plus Study (2003) (174)
Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis (2018) (165)
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study (2009) (148)
Warts in primary schoolchildren: prevalence and relation with environmental factors (2009) (146)
Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. (2015) (139)
Is depression in old age fatal only when people feel lonely? (2005) (134)
High Blood Pressure and Resilience to Physical and Cognitive Decline in the Oldest Old: The Leiden 85‐Plus Study (2012) (133)
Long‐term use of proton pump inhibitors and vitamin B12 status in elderly individuals (2008) (131)
Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial (2010) (129)
C-reactive protein is a strong but nonspecific risk factor of fatal stroke in elderly persons. (2001) (124)
Effectiveness of integrated disease management for primary care chronic obstructive pulmonary disease patients: results of cluster randomised trial (2014) (122)
Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation (2017) (121)
Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study (2004) (119)
Common Chronic Diseases and General Impairments as Determinants of Walking Disability in the Oldest‐Old Population (2002) (119)
The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population-based study (2006) (117)
The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life (2009) (117)
Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies. (2016) (116)
Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning--the DANTE Study Leiden: A Randomized Clinical Trial. (2015) (114)
Impact of mild cognitive impairment on survival in very elderly people: cohort study (1997) (109)
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age (2005) (107)
The Relationship between the Extent of Collaboration of General Practitioners and Pharmacists and the Implementation of Recommendations Arising from Medication Review (2013) (106)
Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia. (2005) (102)
Auditory rehabilitation of older people from the general population--the Leiden 85-plus study. (2003) (102)
Cutaneous wart-associated HPV types: prevalence and relation with patient characteristics. (2012) (101)
Predictive factors of urinary tract infections among the oldest old in the general population. a population-based prospective follow-up study (2011) (100)
Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study. (2005) (99)
Idiopathic Senile Gait Disorders Are Signs of Subclinical Disease (2000) (98)
Effectiveness and cost-effectiveness of a proactive, goal-oriented, integrated care model in general practice for older people. A cluster randomised controlled trial: Integrated Systematic Care for older People—the ISCOPE study (2016) (94)
Vascular disease and apathy in old age. The Leiden 85‐plus Study (2008) (89)
C-Reactive Protein Is a Strong but Nonspecific Risk Factor of Fatal Stroke in Elderly Persons (2000) (85)
Cognitive function in the oldest old: Women perform better than men (2000) (84)
Diabetic retinopathy screening in patients with diabetes mellitus in primary care: Incentives and barriers to screening attendance. (2012) (83)
Natural history of depression in the oldest old (2006) (83)
The 15‐item Geriatric Depression Scale (GDS‐15) detects changes in depressive symptoms after a major negative life event. The Leiden 85‐plus Study (2004) (82)
Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities. (2011) (81)
Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors1 (2004) (80)
Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study. (2002) (74)
The contribution of patient interviews to the identification of drug‐related problems in home medication review (2012) (72)
Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts. (2015) (72)
Disability in the Oldest Old: “Can Do” or “Do Do”? (2001) (72)
Co‐occurrence of depression and anxiety in elderly subjects aged 90 years and its relationship with functional status, quality of life and mortality (2009) (71)
Blood Pressure Variability and Cardiovascular Risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) (2012) (71)
Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function (2003) (70)
Lower blood pressure during antihypertensive treatment is associated with higher all-cause mortality and accelerated cognitive decline in the oldest-old. Data from the Leiden 85-plus Study (2018) (69)
How usual is usual care in pragmatic intervention studies in primary care? An overview of recent trials. (2010) (69)
Subclinical Thyroid Dysfunction and Cognitive Decline in Old Age (2013) (67)
Effects of Medication Review on Drug-Related Problems in Patients Using Automated Drug-Dispensing Systems (2011) (67)
Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism. (2019) (67)
Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: an individual participant data analysis. (2014) (67)
Predicting survival in oldest old people. (2012) (64)
High Blood Pressure, Physical and Cognitive Function, and Risk of Stroke in the Oldest Old: The Leiden 85-Plus Study (2013) (62)
In an observational study elderly patients had an increased risk of falling due to home hazards. (2005) (61)
Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming (2004) (60)
Evaluation of a Novel Broad-Spectrum PCR-Multiplex Genotyping Assay for Identification of Cutaneous Wart-Associated Human Papillomavirus Types (2010) (59)
Natural Course of Cutaneous Warts Among Primary Schoolchildren: A Prospective Cohort Study (2013) (59)
Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study (2013) (58)
Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. (2016) (58)
Comparison of quadriceps strength and handgrip strength in their association with health outcomes in older adults in primary care (2014) (57)
Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age. (2010) (57)
Mortality risk in men is associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR) (1999) (56)
Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study (2018) (56)
Does depression in old age increase only cardiovascular mortality? The Leiden 85‐plus Study (2004) (55)
Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: A randomised controlled trial (DREAMeR-study) (2019) (54)
Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts (2018) (54)
Disability transitions in the oldest old in the general population. The Leiden 85-plus study (2013) (53)
No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85‐plus Study (2002) (53)
Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study (2013) (53)
Medication adherence and knowledge of older patients with and without multidose drug dispensing. (2013) (53)
Late-onset dementia: structural brain damage and total cerebral blood flow. (2005) (52)
Variation in GP decisions on antihypertensive treatment in oldest-old and frail individuals across 29 countries (2017) (52)
Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study. (2008) (50)
Gene dose of apolipoprotein E and age-related hearing loss (2012) (50)
Blood pressure trends and mortality: the Leiden 85-plus Study (2013) (50)
Majority of drug-related problems identified during medication review are not associated with STOPP/START criteria (2015) (49)
Warts Transmitted in Families and Schools: A Prospective Cohort (2013) (48)
Plasma NT-proBNP as predictor of change in functional status, cardiovascular morbidity and mortality in the oldest old: the Leiden 85-plus study (2014) (48)
Chronic kidney disease in patients with diabetes mellitus type 2 or hypertension in general practice. (2010) (47)
Association of APOE e2/e3/e4 and Promoter Gene Variants With Dementia But Not Cardiovascular Mortality in Old Age (2002) (46)
Clinical Relevance of a Raised Plasma N‐Terminal Pro‐Brain Natriuretic Peptide Level in a Population‐Based Cohort of Nonagenarians (2009) (46)
Thyroid status and renal function in older persons in the general population. (2014) (45)
The effect of cognitive impairment on the predictive value of multimorbidity for the increase in disability in the oldest old: the Leiden 85-plus Study (2011) (44)
Prospective study of the effect of blood pressure on renal function in old age: the Leiden 85-Plus Study. (2006) (44)
High prevalence of cutaneous warts in elementary school children and the ubiquitous presence of wart‐associated human papillomavirus on clinically normal skin (2015) (43)
Determinants of absence of osteoarthritis in old age (2011) (43)
Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85‐plus Study (2013) (43)
Temporal Relationship Between Cognitive and Physical Performance in Middle-Aged to Oldest Old People (2016) (41)
Natural course of care dependency in residents of long-term care facilities: prospective follow-up study (2014) (41)
Benzodiazepine use and risk of mortality in individuals aged 85 years or older. (2003) (41)
Framingham Stroke Risk Score and Cognitive Impairment for Predicting First-Time Stroke in the Oldest Old (2013) (40)
Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST) (2017) (40)
Cochrane corner: is integrated disease management for patients with COPD effective? (2014) (39)
Effectiveness of Cranberry Capsules to Prevent Urinary Tract Infections in Vulnerable Older Persons: A Double-Blind Randomized Placebo-Controlled Trial in Long-Term Care Facilities (2014) (38)
Thyroid Function Tests in the Reference Range and Fracture: Individual Participant Analysis of Prospective Cohorts (2017) (38)
Systolic Blood Pressure and Cognitive Decline in Older Adults With Hypertension (2019) (36)
Subclinical thyroid dysfunction and functional capacity among elderly. (2014) (36)
Three-year follow-up of Mini-Mental State Examination score in community residents aged 85 and over (1995) (36)
Effects of a stepped-care intervention programme among older subjects who screened positive for depressive symptoms in general practice: the PROMODE randomised controlled trial. (2012) (36)
Prevalence of Carriers of Intermediate and Pathological Polyglutamine Disease-Associated Alleles Among Large Population-Based Cohorts. (2019) (36)
RECODE: Design and baseline results of a cluster randomized trial on cost-effectiveness of integrated COPD management in primary care (2013) (36)
A community based study of the incidence of dementia in subjects aged 85 years and over. (1995) (36)
HPV type in plantar warts influences natural course and treatment response: secondary analysis of a randomised controlled trial. (2013) (35)
Monochloroacetic acid application is an effective alternative to cryotherapy for common and plantar warts in primary care: a randomized controlled trial. (2015) (35)
The Routine Electrocardiogram for Cardiovascular Risk Stratification in Old Age: The Leiden 85‐Plus Study (2007) (35)
Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus Study. (2005) (35)
Quality of life in community-dwelling older persons with apathy. (2014) (35)
Low blood pressure in the very old, a consequence of imminent heart failure: the Leiden 85-plus Study (2008) (34)
Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review (2010) (34)
Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85 (1999) (33)
Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. (2002) (32)
Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial (2018) (32)
Evidence for the association of the S100β gene with low cognitive performance and dementia in the elderly (2007) (31)
Leisure activities and the risk of dementia. (2003) (31)
Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi‐Inflammatory Biomarkers (2017) (30)
Successful Geriatric Rehabilitation: Effects on Patients' Outcome of a National Program to Improve Quality of Care, the SINGER Study. (2017) (30)
NT-proBNP, blood pressure, and cognitive decline in the oldest old (2014) (30)
Incidence and predictive factors of lower respiratory tract infections among the very elderly in the general population. The Leiden 85-plus Study (2008) (29)
What do older adults with multimorbidity and polypharmacy think about deprescribing? The LESS study - a primary care-based survey (2020) (29)
Homocysteine Levels and Treatment Effect in the Prospective Study of Pravastatin in the Elderly at Risk (2014) (29)
THE BIDIRECTIONAL RELATIONSHIP BETWEEN VISION AND COGNITION: A SYSTEMATIC REVIEW AND META-ANALYSIS. (2020) (28)
Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study (2011) (28)
Evidence-based medicine in older patients: how can we do better? (2015) (28)
Impact of valvular heart disease on activities of daily living of nonagenarians: the leiden 85-plus study a population based study (2010) (28)
Cost-effectiveness of integrated COPD care: the RECODE cluster randomised trial (2015) (28)
Validity of the three apathy items of the Geriatric Depression Scale (GDS‐3A) in measuring apathy in older persons (2017) (28)
Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study (2010) (27)
Unravelling complex primary-care programs to maintain independent living in older people: a systematic overview. (2017) (27)
Geriatric Screening, Triage Urgency, and 30‐Day Mortality in Older Emergency Department Patients (2020) (26)
Level of Satisfaction of Older Persons with Their General Practitioner and Practice: Role of Complexity of Health Problems (2014) (26)
The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data (2018) (25)
Perceived doctor-patient relationship and satisfaction with general practitioner care in older persons in residential homes (2018) (25)
Potentially inappropriate medication and attitudes of older adults towards deprescribing (2020) (25)
Recommendations for (Discontinuation of) Statin Treatment in Older Adults: Review of Guidelines (2019) (25)
Problems experienced by informal caregivers with older care recipients with and without cognitive impairment (2016) (25)
Low thyroid function is not associated with an accelerated deterioration in renal function. (2019) (25)
Lesional HPV types of cutaneous warts can be reliably identified by surface swabs. (2011) (25)
Anaemia in older persons. (2011) (25)
Predictive value of traditional risk factors for cardiovascular disease in older people: A systematic review. (2020) (25)
Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilities. (2013) (24)
Drug‐related problems identified during medication review before and after the introduction of a clinical decision support system (2018) (24)
How general practitioners would deprescribe in frail oldest-old with polypharmacy — the LESS study (2018) (24)
The association of thyroid function and the risk of kidney function decline: a population-based cohort study. (2016) (24)
Predictive Value of a Profile of Routine Blood Measurements on Mortality in Older Persons in the General Population: The Leiden 85-Plus Study (2013) (23)
The Impact of Levothyroxine on Cardiac Function in Older Adults with Mild Subclinical Hypothyroidism: a Randomized Clinical Trial. (2019) (22)
Assistive devices and community-based services among 85-year-old community-dwelling elderly in The Netherlands: Ownership, use,and need for intervention (2006) (22)
High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age (2007) (22)
Current choices in the treatment of cutaneous warts: a survey among Dutch GP. (2010) (21)
Prediction of mortality and functional decline by changes in eGFR in the very elderly: the Leiden 85-plus study (2013) (21)
How do general practitioners identify inflammatory arthritis? A cohort analysis of Dutch general practitioner electronic medical records. (2016) (21)
Benefits of increasing the dose of influenza vaccine in residents of long‐term care facilities: A randomized placebo‐controlled trial (2009) (21)
Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice: an individual participant data meta-analysis (2018) (20)
The additional value of routine electrocardiograms in cardiovascular risk management of older people (2008) (20)
Response to an unsolicited intervention offer to persons aged ≥ 75 years after screening positive for depressive symptoms: a qualitative study (2011) (20)
Cost-Effectiveness of Cranberry Capsules to Prevent Urinary Tract Infection in Long-Term Care Facilities: Economic Evaluation with a Randomized Controlled Trial (2014) (19)
GPs' perspectives on secondary cardiovascular prevention in older age: a focus group study in the Netherlands. (2015) (19)
Markers of autonomic tone on a standard ECG are predictive of mortality in old age. (2006) (19)
The accuracy of plasma natriuretic peptide levels for diagnosis of cardiac dysfunction and chronic heart failure in community-dwelling elderly: a systematic review. (2009) (19)
Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS (2017) (19)
Consequences of Interaction of Functional, Somatic, Mental and Social Problems in Community-Dwelling Older People (2015) (18)
NT-proBNP Best Predictor of Cardiovascular Events and Cardiovascular Mortality in Secondary Prevention in Very Old Age: The Leiden 85-Plus Study (2013) (18)
Prognostic value of cardiovascular disease status: the Leiden 85-plus study (2012) (17)
Variability in Vulnerability Assessment of Older People by Individual General Practitioners: A Cross-Sectional Study (2014) (17)
Physician’s Prescribing Preference as an Instrumental Variable: Exploring Assumptions Using Survey Data (2015) (17)
Assessment of Appropriateness of Screening Community‐Dwelling Older People to Prevent Functional Decline (2012) (17)
Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease. (2015) (16)
Diagnostic accuracy of plasma NT-proBNP levels for excluding cardiac abnormalities in the very elderly (2010) (16)
The use of goal attainment scaling during clinical medication review in older persons with polypharmacy. (2019) (16)
Exploring the variation in implementation of a COPD disease management programme and its impact on health outcomes: a post hoc analysis of the RECODE cluster randomised trial (2015) (16)
Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. (2019) (16)
Older people coping with low mood: a qualitative study (2015) (16)
[Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study']. (2006) (16)
Completeness of medication reviews provided by community pharmacists (2014) (16)
Relationship of patient volume and service concentration with outcome in geriatric rehabilitation. (2013) (16)
Association of Thyroid Dysfunction With Cognitive Function (2021) (16)
Prevalence of five common clinical abnormalities in very elderly people: population based cross sectional study (2003) (16)
Thyroid status and mortality in nonagenarians from long-lived families and the general population (2017) (16)
GPs' perspectives on preventive care for older people: a focus group study. (2012) (15)
Associations of Various Health-Ratings with Geriatric Giants, Mortality and Life Satisfaction in Older People (2016) (15)
General practitioners’ deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries (2021) (15)
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study. (2011) (14)
Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults (2020) (14)
Randomised Controlled Trial of Unsolicited Occupational Therapy in Community-Dwelling Elderly People: The LOTIS Trial (2006) (14)
Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism (2021) (14)
Burden of cardiovascular disease across 29 countries and GPs’ decision to treat hypertension in oldest-old (2018) (14)
N‐terminal pro–brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk (2014) (14)
Seasonal mood variation in the elderly: the Leiden 85‐plus Study (2005) (14)
The effectiveness of functional task exercise and physical therapy as prevention of functional decline in community dwelling older people with complex health problems (2018) (13)
DREAMeR: Drug use Reconsidered in the Elderly using goal Attainment scales during Medication Review; study protocol of a randomised controlled trial (2018) (13)
Yield and costs of direct and stepped screening for depressive symptoms in subjects aged 75 years and over in general practice (2011) (13)
An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms (2020) (13)
No increased mortality risk in older persons with unexplained anaemia. (2012) (13)
The influence of the administration method on scores of the 15-item Geriatric Depression Scale in old age (2012) (12)
International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey. (2015) (12)
Clinically diagnosed infections predict disability in activities of daily living among the oldest-old in the general population: the Leiden 85-plus Study (2013) (12)
An Internet-based Acceptance and Commitment Therapy intervention for older adults with anxiety complaints: study protocol for a cluster randomized controlled trial (2018) (12)
Evaluation of continuous summary physical performance scores (CSPPS) in an elderly cohort (2005) (12)
049 HANDGRIP STRENGTH AND MORTALITY IN THE OLDEST OLD: THE LEIDEN 85-PLUS STUDY (2010) (12)
Changes in geriatric rehabilitation: a national programme to improve quality of care. The Synergy and Innovation in Geriatric Rehabilitation study (2015) (12)
Patient Characteristics and General Practitioners’ Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries (2019) (11)
Time trends in preventive drug treatment after myocardial infarction in older patients. (2010) (11)
The Dilemma of Treating Subclinical Hypothyroidism: Risk that Current Guidelines Do More Harm than Good (2014) (11)
Associations of elevated anti-TPO antibodies with thyroid function, survival, functioning and depressive symptoms in the oldest old: the Leiden 85-plus Study. (2019) (11)
Increase in N-terminal pro-brain natriuretic peptide levels, renal function and cardiac disease in the oldest old. (2015) (11)
Self-Reported Hindering Health Complaints of Community-Dwelling Older Persons: A Cross-Sectional Study (2015) (11)
Feasibility and acceptability of the ‘Acutely Presenting Older Patient’ screener in routine emergency department care (2020) (10)
Statin Use and Self-Reported Hindering Muscle Complaints in Older Persons: A Population Based Study (2016) (10)
L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms (2020) (10)
Cost‐utility and cost‐effectiveness analysis of a clinical medication review focused on personal goals in older persons with polypharmacy compared to usual care: Economic evaluation of the DREAMeR study (2020) (10)
The effect of pain on presence and severity of depressive disorders in older persons: The role of perceived control as mediator. (2016) (10)
Clinical determinants of low handgrip strength and its decline in the oldest old: the Leiden 85-plus Study (2020) (10)
The clinically meaningful change in physical performance scores in an elderly cohort (2007) (10)
PREDICTIVE VALUE OF LOW FERRITIN IN OLDER PERSONS WITH ANEMIA WITH AND WITHOUT INFLAMMATION: THE LEIDEN 85‐PLUS STUDY (2010) (9)
Satisfaction in Older Persons and General Practitioners during the Implementation of Integrated Care (2016) (9)
A Structured Process Description of a Pragmatic Implementation Project: Improving Integrated Care for Older Persons in Residential Care Homes (2017) (9)
Outcomes of Thyroid Dysfunction in People Aged Eighty Years and Older: An Individual Patient Data Meta-Analysis of Four Prospective Studies (Towards Understanding Longitudinal International Older People Studies Consortium) (2020) (9)
Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials (2021) (9)
The effect of a telephone follow-up call for older patients, discharged home from the emergency department on health-related outcomes: a systematic review of controlled studies (2021) (8)
Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over (2018) (8)
Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial (2020) (8)
Mental Health in Primary Care (2018) (8)
Mental Health in Primary Care (2018) (8)
Low Thyroid Function and Anemia in Old Age: The Leiden 85‐Plus Study (2015) (8)
[Combined vision and hearing impairment: in an estimated 30,000-35,000 people aged 55 years or over in The Netherlands]. (2007) (8)
Effectiveness of intramuscular gluteal glucocorticoid injection versus intra-articular glucocorticoid injection in knee osteoarthritis: design of a multicenter randomized, 24 weeks comparative parallel-group trial (2020) (8)
The effect of vitamin B12 and folic acid supplementation on routine haematological parameters in older people: an individual participant data meta-analysis (2018) (8)
Outcomes of thyroid dysfunction in people aged 80 years and older: an individual patient data meta-analysis of four prospective studies (TULIPS consortium). (2020) (7)
Anaemia and physical and mental health in the very old: An individual participant data meta-analysis of four longitudinal studies of ageing. (2020) (7)
Evaluation of High Cholesterol and Risk of Dementia and Cognitive Decline in Older Adults Using Individual Patient Meta-Analysis (2021) (7)
Combined impact of future trends on healthcare utilisation of older people: A Delphi study. (2019) (7)
Is education a demographic dividend? The role of cognitive reserve in dementia-related cognitive decline: a comparison of six longitudinal studies of ageing (2015) (6)
Implementation of the acutely presenting older patient (APOP) screening program in routine emergency department care (2021) (6)
Subclinical thyroid disorders (2012) (6)
High Sensitivity Cardiac Troponin T and Cognitive Function in the Oldest Old: The Leiden 85-Plus Study. (2017) (6)
Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease (2019) (6)
Prediction of functional decline in community-dwelling older persons in general practice: a cohort study (2018) (6)
The APOP screener and clinical outcomes in older hospitalised internal medicine patients. (2020) (6)
Does depression specifically increase cardiovascular mortality? (2005) (6)
Wishes and needs of community-dwelling older persons concerning general practice: A qualitative study (2018) (6)
A Postal Screener for Pain and Need for Treatment in Older Persons in Primary Care (2014) (6)
Sunday, 26 August 2012 (2012) (5)
Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial (2018) (5)
Association Between Glycosylated Hemoglobin and Cardiovascular Events and Mortality in Older Adults without Diabetes Mellitus in the General Population: The Leiden 85‐Plus Study (2015) (5)
Warts: cryotherapy, salicylic acid or expectantly awaiting? a randomised controlled trial (2008) (4)
Effectiveness and cost-effectiveness of a proactive, goal-oriented, integrated care model in general practice for older people. Integrated Systematic Care for older People–the ISCOPE study (2013) (4)
Vitamin B 12 and Folate and the Risk of Anemia in Old Age (2008) (4)
Managing hypertension in frail oldest-old—The role of guideline use by general practitioners from 29 countries (2019) (4)
Changes in patient satisfaction related to their perceived health state during implementation of improved integrated care for older persons (2019) (4)
Risk stratification and treatment effect of statins in secondary cardiovascular prevention in old age: Additive value of N-terminal pro-B-type natriuretic peptide (2016) (4)
population based study cognitive impairment in old age: prospective Temporal relation between depression and (2007) (4)
Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial. (2022) (4)
Latent class analysis of the Apathy Scale does not identify subtypes of apathy in general population‐based older persons (2016) (4)
Plasma NT-proBNP as predictor of change in functional status, cardiovascular morbidity and mortality in the oldest old: the Leiden 85-plus study (2013) (3)
Goal Attainment Scaling with older people in general practice: a feasibility study (2020) (3)
HPV type‐specific distribution among family members and linen in households of cutaneous wart patients (2021) (3)
Do we AGREE on the targets of antihypertensive drug treatment in older adults: a systematic review of guidelines on primary prevention of cardiovascular diseases (2021) (3)
Cooperation Instead of Competition (2011) (3)
Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies (2022) (3)
Relation between erythropoietin, hemoglobin and renal function in the oldest old. The Leiden 85-plus Study (2010) (3)
Research on multimorbidity in primary care. Selected abstracts from the EGPRN meeting in Tampere, Finland, 9–12 May 2019 (2019) (2)
Is integrated disease management of CORD effective? Results of the RECODE cluster randomized controlled trial in real world patients (2014) (2)
Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies (2019) (2)
SS9.01: Independent living with multimorbidity? Your GP is ready for it! (2014) (2)
Visual impairment as a predictor for deterioration in functioning: the Leiden 85-plus Study (2022) (2)
Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: an individual patient data meta-analysis (2022) (2)
Cost-Effectiveness of a COPD Disease Management Program in Primary Care: The Recode Cluster Randomized Trial. (2014) (2)
Declining daily functioning as a prelude to a hip fracture in older persons—an individual patient data meta-analysis (2022) (2)
Drug prescription rates in secondary cardiovascular prevention in old age: Do vulnerability and severity of the history of cardiovascular disease matter? (2015) (2)
Positive health during the COVID-19 pandemic: a survey among community-dwelling older individuals in the Netherlands (2022) (2)
A proactive approach to complex problems in older people (2009) (2)
No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials (2022) (2)
Increased risk of mortality associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR) (1999) (2)
Structured scoring of supporting nursing tasks to enhance early discharge in geriatric rehabilitation: The BACK-HOME quasi-experimental study. (2016) (2)
Lower Performance in Orientation to Time and Place Associates with Greater Risk of Cardiovascular Events and Mortality in the Oldest Old: Leiden 85-Plus Study (2017) (2)
Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank (2021) (2)
Variation in treatment strategies of Swiss general practitioners for subclinical hypothyroidism in older adults. (2015) (2)
Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials (2022) (2)
Effect of Intramuscular vs Intra-articular Glucocorticoid Injection on Pain Among Adults With Knee Osteoarthritis (2022) (2)
Total Joint Replacement in the Past Does Not Relate to a Deteriorated Functional Level and Health Status in the Oldest Old (2012) (2)
Experiences with and attitudes towards geriatric screening among older emergency department patients: a qualitative study (2021) (2)
Biomarkers versus traditional risk factors to predict cardiovascular events in very old adults: cross-validated prospective cohort study (2020) (2)
Telephone follow‐up to reduce unplanned hospital returns for older emergency department patients: A randomized trial (2021) (2)
Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies (2022) (2)
[The guideline 'Cardiovascular risk management' is too simplified for elderly care]. (2012) (1)
Statins and blood pressure. (2008) (1)
How to interprete subclinical thyroid dysfunction in the prevention and management of heart failure events? Individual participant data analysis from six prospective cohorts (2012) (1)
Chapter 7 Low production capacity of Interleukin-10 is associated with the metabolic syndrome and type-2 diabetes (2000) (1)
A comparison of drug-related problems before and after the introduction of a clinical decision support system during medication review (2016) (1)
Majority of drug-related problems identified during medication review are not associated with STOPP/START criteria (2015) (1)
Measuring daily functioning in older persons using a frailty index: a cohort study based on routine primary care data. (2020) (1)
Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium. (2023) (1)
Change in N-terminal pro B-type natriuretic peptide levels in the oldest old: The Leiden 85-plus Study (2013) (1)
SUBCLINICAL HYPOTHYROIDISM AND THE RISK OF CORONARY HEART DISEASE AND MORTALITY : AN INDIVIDUAL PARTICIPANT DATA ANALYSIS FROM NINE PROSPECTIVE COHORT STUDIES (2010) (1)
Disability transitions in the oldest old in the general population. The Leiden 85-plus study (2013) (1)
103PERSPECTIVES ON QUALITY OF TRANSITIONAL CARE FROM HOSPITAL TO HOME FOR VULNERABLE OLDER PATIENTS (2019) (1)
[Causes and consequences of cognitive decline in the very elderly; the 'Leiden 85-plus Study']. (2004) (1)
Thyroid dysfunction and the risk of dementia and cognitive decline: Systematic review, meta-analysis and clinical implications (2016) (1)
[The complexity of medical care of frail older patients]. (2014) (1)
Cryotherapy is the most effective treatment for common warts in general practice (2011) (1)
Academic networks for more integration and more demand-driven care and support for people with complex needs (2018) (1)
Intramuscular gluteal glucocorticoid injection versus intra-articular glucocorticoid injection in knee osteoarthritis: a 24-week multicenter randomized controlled non-inferiority trial (2021) (1)
RECODE: RCT on effectiveness of integrated COPD management in primary care (2011) (1)
317 Plasma NT‐proBNP of the very elderly in the general population: a prospective study (2008) (1)
Self-efficacy is independently associated with brain volume in older women (2012) (1)
cohort study in older people: population based observational biomarkers to predict cardiovascular mortality Use of Framingham risk score and new (2009) (1)
Does depression specifically increase cardiovascular mortality? [3] (multiple letters) (2005) (1)
[The relationship between atherosclerosis, cognitive impairment, and depression in old age]. (2006) (1)
[A treatment plan as method and compass]. (2015) (1)
[Medication review in older people: identification of a new risk group]. (2015) (1)
Proximity to death is associated with frequency of GP contacts in the oldest old: the Leiden 85-plus study. (2012) (1)
SS2.02: Subclinical hypothyroidism in older age (2014) (0)
[Disciplinary proceedings on screening and preventive diagnostics]. (2009) (0)
101OLDER PATIENTS' SATISFACTION WITH EMERGENCY DEPARTMENT CARE (2019) (0)
articleSubnormal vitamin B 12 concentrations and anaemia in older people : a systematic review (2015) (0)
Receptorsof CD4 T Cells Expressing Killer Ig-Like Phenotypic and Functional Characterization (2004) (0)
Thyroid Status and Survival in Old Age—Reply (2005) (0)
102GERIATRIC VULNERABILITY IN OLDER EMERGENCY DEPARTMENT PATIENTS ACCORDING TO ELECTRONIC HEALTH RECORDS (2019) (0)
Comparison of quadriceps strength and handgrip strength in their association with health outcomes in older adults in primary care (2014) (0)
' s response to reviews Title : Impact of valvular heart disease on daily living activity of nonagenarians : The Leiden 85-plus study (2009) (0)
[Should subclinical hypothyroidism in older persons be treated?]. (2012) (0)
Longitudinal Study of the Cognitive Function of the Oldest Old (1992) (0)
Costs-effectiveness of cranberry capsules to prevent urinary tract infections in long- term care facilities: economic evaluation with a randomized controlled trial (2015) (0)
P755The impact of levothyroxine on cardiac function in older adults with subclinical hypothyroidism: a randomized clinical trial (2019) (0)
82A CONTRIBUTION TO THE AGEING SOCIETY BY INTERDISCIPLINARY EDUCATION: THE MASTER’S PROGRAMME ON VITALITY AND AGEING (2019) (0)
risk stratification and treatment effect of statins in secondary cardiovascular prevention in old age: additive value of nt-probnp (2015) (0)
Erratum to: Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study (2012) (0)
dementia in subjects aged 85 years and over . A community based study of the incidence of (0)
SUBCLINICAL THYROID DYSFUNCTION AND FRACTURE RISK : AN INDIVIDUAL PARTICIPANT DATA ANALYSIS OF PROSPECTIVE COHORTS (2014) (0)
[Cardiovascular prevention in the over-80 age group is not beneficial]. (2008) (0)
Older individuals’ views on their personal screening results for complex health problems: a qualitative study (2020) (0)
The effectiveness of integrated disease management (IDM) programmes for COPD patients : A Cochrane systematic review (2013) (0)
Self-perceived functioning and (instrumental) activities of daily living questionnaires after a hip fracture: Do they tell the same story? (2022) (0)
Abstracts SwissFamilyDocs Conference 2014 Swiss Quality indicators for diabetes management in Swiss primary based on Identifying and discouraging overuse in Swiss Is More Project (0)
Satisfaction of older persons with their primary health care practice. Driven by age or complexity of health problems? Results from the ISCOPE Study (2013) (0)
Effects of discontinuation of levothyroxine treatment in older adults: protocol for a self-controlled trial (2023) (0)
100ADHERENCE TO GERIATRIC EMERGENCY DEPARTMENT GUIDELINES IN ROUTINE CARE (2019) (0)
Chapter 6 Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function : The Leiden 85-plus Study (2000) (0)
Prognostic value of cardiovascular disease status: the Leiden 85-plus study (2012) (0)
[Coping strategies of older people with low mood]. (2016) (0)
Correction: Predictive Value of a Profile of Routine Blood Measurements on Mortality in Older Persons in the General Population: The Leiden 85-Plus Study (2015) (0)
Assessment of the appropriateness of cardiovascular preventive medication in older people: using the RAND/UCLA Appropriateness Method (2022) (0)
Integrated disease mangement interventions for patients with chronic pulmonary disease (review) (2013) (0)
APPROPRIATENESS OF CARDIOVASCULAR PREVENTIVE MEDICATION IN OLDER PEOPLE: A QUALITATIVE RAM-STUDY (2022) (0)
Are general practitioners willing to deprescribe in oldest-old patients with polypharmacy? (2019) (0)
THE DANTON STUDY - DISCONTINUATION OF ANTIHYPERTENSIVE TREATMENT IN OLDER PEOPLE WITH DEMENTIA LIVING IN A NURSING HOME: RESULTS OF A RANDOMIZED CONTROLLED TRIAL (2022) (0)
Chapter 8 Inflammation and Stroke (0)
The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis (2022) (0)
Assessment of evidence for screening community-dwelling older people (2010) (0)
Integrated disease management interventions for chronic obstructive pulmonary disease (2014) (0)
Screening for presence of pain and need for care at old age in general practice (2013) (0)
Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study (2011) (0)
Receptors of CD4 T Cells Expressing Killer Ig-Like Phenotypic and Functional Characterization (2004) (0)
Geriatric screening, fall characteristics and 3- and 12 months adverse outcomes in older patients visiting the emergency department with a fall (2021) (0)
Assessment of Appropriateness of Cardiovascular Preventive Medication in Adults ≥ 75 years (2020) (0)
Thyroid status and survival in old age. Authors' reply (2005) (0)
Effectiveness of intramuscular corticosteroid injection versus intra-articular injection in patients with knee osteoarthritis: design of an open pragmatic randomized controlled trial (2018) (0)
Proxy Decision-Making for Clinical Research in Nursing Home Residents With Dementia: A Qualitative Analysis. (2023) (0)
Response to David Nace and Paul Drinka (2014) (0)
Thyroid hormone replacement therapy for subclinical hypothyroidism in adults: systematic review and meta-analysis of randomized-controlled trials (2018) (0)
Is integrated COPD care cost-effective? (2016) (0)
The impact of atherosclerosis on cognitive function (2001) (0)
Receptors of CD 4 T Cells Expressing Killer Ig-Like Phenotypic and Functional Characterization (2004) (0)
Title Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants : a cross-sectional study (2018) (0)
Subclinical thyroid dysfunction, functional capacity and cognitive performance in old age (2013) (0)
Using a new matrix to describe real-life integrated care innovation for older persons in primary care (2018) (0)
Effects and costs of a combined screening and treatment program for elderly (aged 75 years and over) with depressive symptoms in general practice (2006) (0)
Role of Vitamin B12 in Anemia in Old Age--Reply (2009) (0)
' s response to reviews Title : Natural course of care dependency in residents of long-term care facilities : Prospective follow-up study (2014) (0)
[Cost-effectiveness research in elderly residents in long-term care: prevention is better than cure, but not always cheaper]. (2015) (0)
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies (2022) (0)
The effects of single and a combination of determinants of anaemia in the very old: results from the TULIPS consortium (2021) (0)
Perceptions of elderly patients interviewed after screening on depressive feelings (2013) (0)
TRUST; Multimodal effects of Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism; a randomised placebo-controlled trial (2011) (0)
DISENTANGLING THE VARYING ASSOCIATIONS BETWEEN SYSTOLIC BLOOD PRESSURE AND HEALTH OUTCOMES IN THE VERY OLD: AN INDIVIDUAL PATIENT DATA META-ANALYSIS. (2022) (0)
Effectiveness of innovations in geriatric rehabilitation. The SINGER Study (2013) (0)
Correction: Statin Use and Self-Reported Hindering Muscle Complaints in Older Persons: A Population Based Study (2021) (0)
Classical cardiovascular risk factors and secondary major coronary events: A Mendelian randomization study in the UK biobank population (2021) (0)
Vascular disease and apathy symptoms in the very old: A cross‐sectional and longitudinal meta‐analysis of individual participant data (2022) (0)
Cognitive function in old age but not mood is dependent on a ER22/23EK variation in the glucocorticoid receptor gene. The Leiden 85-plus Study. (2007) (0)
Further evidence for atherosclerosis underlying dementia in the oldest old (2001) (0)
[Education within the Dutch National Care for the Elderly Programme]. (2016) (0)
An international case-vignette study to assess general practitioners’ willingness to deprescribe (LESS) (2018) (0)
The effect of thyroid hormone therapy on muscle function, strength and mass in older adults with subclinical hypothyroidism-an ancillary study within two randomized placebo controlled trials. (2023) (0)
Erratum to: Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study (2012) (0)
A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting (2023) (0)
International Evaluations of Cognitive Reserve and Cognitive Decline in Preclinical Stages of Dementia (2015) (0)
Systematic Review of Guidelines on Antihypertensive Treatment in Older Adults: SPRINTing to More Heterogeneity? (2020) (0)
OP06 Is education a demographic dividend? international evaluations of cognitive reserve and cognitive decline in preclinical stages of dementia: evidence from four longitudinal studies of ageing (2015) (0)
The effect of levothyroxine therapy on depressive symptoms in adults with subclinical hypothyroidism (2020) (0)
' s response to reviews Title : Predictive Factors of Urinary Tract Infections among the Oldest Old in the General Population . A Population Based Prospective Follow-up Study (2011) (0)

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