Jacques Pouysségur

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Jacques Pouysségur

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Philosophy

Why Is Jacques Pouysségur Influential?

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According to Wikipedia, Jacques Pouysségur is a French engineer and researcher. He was born on November 10, 1943, in Toulouse, Haute-Garonne. He is a research director emeritus of the CNRS. He has conducted research at the Institute for Research on Cancer and Aging, Nice , at the University of Nice Sophia Antipolis. From 2013 to 2021, he also worked in the Department of Medical Biology, Scientific Centre of Monaco . He has been the head of the Tumor Hypoxia and Metabolism Team and a visiting professor at Kyoto Medical University, Kyoto, Japan, since 2013.

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Jacques Pouysségur's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Tumor cell metabolism: cancer's Achilles' heel. (2008) (2036)
Hypoxia signalling in cancer and approaches to enforce tumour regression (2006) (1614)
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia (2003) (1307)
Cyclin D1 Expression Is Regulated Positively by the p42/p44MAPK and Negatively by the p38/HOGMAPK Pathway* (1996) (1286)
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains (2009) (1250)
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007) (1084)
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. (1993) (1000)
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. (2016) (889)
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1* (1999) (831)
Hypoxia and cancer (2007) (745)
Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+ H+ (1989) (736)
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. (1999) (716)
ERK implication in cell cycle regulation. (2007) (686)
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts (1993) (674)
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. (2009) (665)
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. (2000) (662)
Molecular physiology of vertebrate Na+/H+ exchangers. (1997) (653)
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity (2006) (648)
Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry (1999) (622)
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress (2004) (558)
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009) (546)
Hypoxia-induced autophagy: cell death or cell survival? (2010) (544)
A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. (1984) (504)
Disrupting proton dynamics and energy metabolism for cancer therapy (2013) (500)
Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory (2002) (480)
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. (1999) (444)
Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors. (2005) (428)
Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD. (1990) (424)
Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms. (1995) (411)
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. (2006) (404)
Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms* (2002) (395)
The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and −2 Are Induced by the p42/p44MAPK Cascade* (1997) (392)
Targeting the ERK signaling pathway in cancer therapy (2006) (391)
cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca2+ mobilization (1991) (390)
Oxygen, a source of life and stress (2007) (389)
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors (2011) (380)
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity (2011) (375)
The Expanding Family of Eucaryotic Na+/H+Exchangers* (2000) (373)
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. (2003) (355)
The role of erk1 and erk2 in multiple stages of T cell development. (2005) (334)
p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts* (1998) (333)
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. (1977) (327)
Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3). (1992) (322)
pH control mechanisms of tumor survival and growth (2011) (317)
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. (2002) (316)
Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport. (1984) (311)
Hypoxia signalling controls metabolic demand. (2007) (308)
Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases (2002) (304)
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. (2005) (302)
PHD2 mutation and congenital erythrocytosis with paraganglioma. (2008) (299)
The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. (1994) (298)
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. (2006) (285)
Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. (1992) (279)
Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series. (1984) (272)
Hypoxia-inducible Factor 1 Transactivates the Human Leptin Gene Promoter* (2002) (270)
The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing". (1992) (269)
Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. (1993) (265)
Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. (1998) (262)
Serotonin stimulates DNA synthesis in fibroblasts acting through 5–HT1B receptors coupled to a Gi-protein (1988) (256)
Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation (1977) (250)
PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis (2008) (247)
c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors (1985) (247)
Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective. (1994) (247)
Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts. (1994) (240)
HIF at a glance (2009) (231)
Abrogation of p27Kip1 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts* (1996) (230)
Hypoxia and energetic tumour metabolism. (2011) (230)
Growth Factor–induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins (1998) (229)
Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts (1977) (226)
MAP Kinases and Hypoxia in the Control of VEGF Expression (2004) (225)
Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. (2005) (224)
Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin (1987) (223)
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters (2015) (223)
MEK1-ERK2 Signaling Pathway Protects Myocardium From Ischemic Injury In Vivo (2004) (223)
Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition. (1992) (223)
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages (2018) (219)
Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts (1985) (217)
Angiogenesis: how a tumor adapts to hypoxia. (1999) (214)
Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. (1992) (213)
Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels (2007) (204)
Focal localization of the NHE‐1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH. (1993) (202)
Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). (1993) (201)
Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. (1993) (200)
Stress-activated Protein Kinases (JNK and p38/HOG) Are Essential for Vascular Endothelial Growth Factor mRNA Stability* (2000) (199)
The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling (2006) (199)
Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. (2000) (198)
Growth factors activate the Na+/H+ antiporter in quiescent fibroblasts by increasing its affinity for intracellular H+. (1984) (197)
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines (2013) (195)
The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1 (2008) (194)
HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome (2007) (193)
The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors* (1997) (190)
Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation. (1982) (189)
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility (2007) (189)
The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal. (2000) (184)
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy? (2016) (183)
Redox regulation of the hypoxia-inducible factor (2006) (183)
Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. (1994) (181)
Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites. (1991) (180)
Transforming Growth Factor β1 (TGF-β1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-α Signaling (2001) (174)
The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. (2006) (172)
Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts. (1995) (171)
Cytoplasmic Domain of the Ubiquitous Na+/H+ Exchanger NHE1 Can Confer Ca2+ Responsiveness to the Apical Isoform NHE3 (*) (1995) (170)
Mutant α subunits of Gi2 inhibit cyclic AMP accumulation (1991) (170)
Growth factor activation and "H(+)-sensing" of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation. (1994) (170)
Serotonin as a growth factor. (1990) (169)
Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers. (1994) (166)
p70 S6 Kinase-mediated Protein Synthesis Is a Critical Step for Vascular Endothelial Cell Proliferation* (1999) (165)
Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival (2012) (164)
Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts. (1983) (161)
Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. (2008) (160)
Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. (1991) (159)
Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. (1992) (159)
Role of a Na+-dependent Cl-/HCO3- exchange in regulation of intracellular pH in fibroblasts. (1985) (159)
Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis. (1992) (158)
Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist. (1993) (157)
High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer (2010) (157)
HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. (2004) (155)
Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells (2005) (148)
Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension. (1991) (148)
Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. (1992) (148)
Hypoxia‐inducible factor‐1α (HIF‐1α) escapes O2‐driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm (2001) (147)
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy. (2019) (147)
A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis. (1993) (145)
Distinct Cell Cycle Timing Requirements for Extracellular Signal-Regulated Kinase and Phosphoinositide 3-Kinase Signaling Pathways in Somatic Cell Mitosis (2002) (144)
HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation (2001) (143)
The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts. (1986) (141)
Transmembrane receptors and intracellular pathways that control cell proliferation. (1992) (141)
The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases. (2001) (140)
Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation (2005) (138)
Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. (1994) (134)
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. (2002) (134)
Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation. (1992) (133)
Signaling Angiogenesis via p42/p44 MAP Kinase Cascade (2000) (133)
Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C. (1993) (132)
Low cytoplasmic pH inhibits endocytosis and transport from the trans- Golgi network to the cell surface (1989) (131)
The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain. (1994) (130)
EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway (2003) (130)
Hypoxia: the tumor's gateway to progression along the angiogenic pathway. (2001) (129)
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). (1994) (129)
Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin. (2015) (129)
Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia (2009) (126)
The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. (2011) (126)
TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation* (2011) (126)
Pertussis toxin inhibits thrombin‐induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts. (1986) (124)
Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b (2004) (123)
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein‐coupled thrombin receptor. (1996) (123)
Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs. (2003) (122)
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism (2018) (121)
Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform. (1993) (120)
Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide‐specific phospholipase C. (1988) (119)
Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0----G1 transition of fibroblasts. (1986) (119)
Further evidence for a phospholipase C-coupled G protein in hamster fibroblasts. Induction of inositol phosphate formation by fluoroaluminate and vanadate and inhibition by pertussis toxin. (1987) (119)
Harnessing the hypoxia-inducible factor in cancer and ischemic disease. (2007) (119)
HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. (2007) (119)
The growth factor-activatable Na+/H+ exchange system: a genetic approach (1985) (118)
A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry. (1996) (118)
Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines. (1996) (118)
Mammalian MAP kinase modules: how to transduce specific signals. (1997) (117)
Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α* (2000) (116)
Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. (2016) (116)
ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization. (1994) (115)
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli (2009) (114)
Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses. (2019) (113)
Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response (2019) (111)
Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interaction. (1997) (111)
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. (2011) (110)
Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF* (2005) (110)
Proton dynamics in cancer (2010) (110)
ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation*♦ (2009) (109)
Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses (1996) (109)
Confluence of Vascular Endothelial Cells Induces Cell Cycle Exit by Inhibiting p42/p44 Mitogen-Activated Protein Kinase Activity (1999) (108)
cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. (1991) (108)
cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition (1996) (105)
ERK2 but not ERK1 plays a key role in hepatocyte replication: An RNAi‐mediated ERK2 knockdown approach in wild‐type and ERK1 null hepatocytes (2007) (105)
Okadaic acid, a phosphatase inhibitor, induces activation and phosphorylation of the Na+/H+ antiport. (1991) (104)
In vivo pH in metabolic‐defective Ras‐transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH (2012) (104)
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium (2015) (104)
Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1) (1994) (103)
SUMOylation of hypoxia-inducible factor-1α reduces its transcriptional activity (2007) (103)
Oxygen Tension Regulates Pancreatic β-Cell Differentiation Through Hypoxia-Inducible Factor 1α (2009) (101)
Hypoxia and cellular metabolism in tumour pathophysiology (2017) (101)
Total ERK1/2 activity regulates cell proliferation (2009) (100)
Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3* (2000) (99)
Angiogenesis and G-protein-coupled receptors: signals that bridge the gap (2001) (98)
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5) (2018) (98)
Hypoxia in cancer cell metabolism and pH regulation. (2007) (97)
Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma Protuberans (DP) (2001) (97)
MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ (2002) (96)
Regulation of Tumor Cell Motility by ERK Mitogen‐Activated Protein Kinases (2004) (95)
Transcriptional regulation of VCAM‐1 expression by tumor necrosis factor‐α in human tracheal smooth muscle cells: Involvement of MAPKs, NF‐κB, p300, and histone acetylation (2006) (95)
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling. (2001) (93)
Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts (1997) (93)
TGF‐β inhibits growth factor‐induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events (1988) (93)
Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome. (2014) (93)
Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype. (1980) (92)
Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism. (2016) (90)
A Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment (2008) (90)
Overexpression of carbonic anhydrase XII in tissues from resectable non‐small cell lung cancers is a biomarker of good prognosis (2011) (90)
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. (2006) (89)
A functional role for the p62–ERK1 axis in the control of energy homeostasis and adipogenesis (2010) (89)
p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor. (1991) (89)
The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors (*) (1995) (89)
Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway* (1996) (88)
Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1). (1992) (88)
Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer (2020) (87)
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor (2004) (86)
The hypoxia-inducible factor and tumor progression along the angiogenic pathway. (2005) (86)
Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production. (1994) (84)
Spatiotemporal regulation of the p42/p44 MAPK pathway (2001) (84)
Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior (2008) (83)
Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization (2009) (81)
Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE‐1 isoform via Gi‐mediated mitogen activated protein kinase signaling transduction pathways (1999) (80)
Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant. (1977) (80)
[Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells]. (2006) (79)
A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets. (1993) (79)
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm. (2001) (79)
Enhanced phosphorylation of the C‐terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases. (1994) (78)
The Mouse p44 Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase 1) Gene (1995) (78)
Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress. (1995) (77)
The Na+/HCO3− Co‐Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells (2015) (76)
Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors. (1998) (76)
Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells (2012) (76)
Growth factors activate the bumetanide-sensitive Na+/K+/Cl-cotransport in hamster fibroblasts. (1986) (75)
Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains. (1997) (74)
Post-translational and Activation-dependent Modifications of the G Protein-coupled Thrombin Receptor (*) (1995) (73)
HIF‐1α mediates the induction of IL‐8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT‐like behaviour (2010) (73)
Polar Opposites: Erk Direction of CD4 T Cell Subsets (2012) (71)
The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code (2017) (71)
Cyclic AMP inhibits mitogen‐induced DNA synthesis in hamster fibroblasts, regardless of the signalling pathway involved (1989) (70)
Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. (2015) (70)
pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth. (2001) (70)
Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors. (1990) (70)
Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis. (2003) (70)
EGF and insulin action in fibroblasts (1986) (69)
Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins. (1976) (68)
Structure of the 5'-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1. (1991) (68)
Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1. (1997) (67)
Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance. (2012) (67)
Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia (2017) (67)
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 (2010) (66)
Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells. (1986) (66)
Identification of the protein and cDNA of the cardiac Na+ /H+ exchanger (1991) (66)
Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis. (1991) (65)
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels (2013) (65)
Distinct Mechanisms Regulate 5-HT2 and Thrombin Receptor Desensitization (*) (1995) (64)
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol (2002) (64)
Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis (2013) (64)
Oxygen, Hypoxia, and Stress (2007) (64)
A Novel Role for IκB Kinase (IKK) α and IKKβ in ERK-Dependent Up-Regulation of MUC5AC Mucin Transcription by Streptococcus pneumoniae1 (2007) (62)
PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation* (2003) (62)
Coupling between phosphoinositide breakdown and early mitogenic events in fibroblasts. Studies with fluoroaluminate, vanadate, and pertussis toxin. (1987) (62)
Identification of a tetrodotoxin-sensitive Na+ channel in a variety of fibroblast lines (1980) (62)
Growth factor-stimulated protein phosphorylation in G0/G1-arrested fibroblasts. Two distinct classes of growth factors with potentiating effects. (1983) (61)
TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways. (1995) (61)
Signaling Pathways of the Thrombin Receptor (1993) (61)
alpha‐Thrombin‐induced early mitogenic signalling events and G0 to S‐phase transition of fibroblasts require continual external stimulation. (1985) (61)
SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. (2007) (60)
Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1). (1995) (60)
Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality: Erk1 Deficiency Enhances the Impairment of Neurogenesis in Erk2-Deficient Mice (2011) (60)
Genetic Control of the 2-Keto-3-Deoxy-d-Gluconate Metabolism in Escherichia coli K-12: kdg Regulon (1974) (59)
Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1 (2007) (59)
Na+/H+ antiporter gene expression increases during retinoic acid‐induced granulocytic differentiation of HL60 cells (1992) (59)
Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C. (1988) (59)
Mutants of mouse fibroblasts altered in the synthesis of cell surface glycoproteins. Preliminary evidence for a defect in the acetylation of glucosamine 6-phosphate. (1977) (58)
Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export. (2016) (57)
Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration. (2010) (57)
Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia (2012) (56)
Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways. (1988) (56)
The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1. (2004) (55)
Differential regulation of Na+/H+ antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli. (1990) (55)
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status (2014) (54)
Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation. (2006) (54)
Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death. (2017) (53)
B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222. (1995) (53)
Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter. (1986) (51)
Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family (1993) (51)
Isolation and immunological characterization of a glucose-regulated fibroblast cell surface glycoprotein and its nonglycosylated precursor (1978) (51)
α‐Thrombin‐induced inositol phosphate formation in go‐arrested and cycling hamster lung fibroblasts: Evidence for a protein kinase C‐mediated desensitization response (1986) (50)
HIF‐Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell‐Based Therapies for the Treatment of Critical Limb Ischemia (2014) (50)
An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression (1998) (50)
HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration (2008) (50)
Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway. (2009) (48)
Lactate and Acidity in the Cancer Microenvironment (2020) (47)
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. (2002) (47)
The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. (2010) (46)
Multiple division cycles and long‐term survival of hepatocytes are distinctly regulated by extracellular signal‐regulated kinases ERK1 and ERK2 (2009) (46)
Effect of mutations affecting Na+:H+ antiport activity on tumorigenic potential of hamster lung fibroblasts (1988) (46)
Targeting pH regulating proteins for cancer therapy-Progress and limitations. (2017) (46)
Tie1 deficiency induces endothelial–mesenchymal transition (2012) (45)
Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. (1991) (45)
Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis. (2013) (45)
Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype. (1991) (44)
Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death (2020) (44)
The cytoplasmic domain of the Na+/H+ exchangers (NHEs) dictates the nature of the hormonal response: behavior of a chimeric human NHE1/trout beta NHE antiporter. (1994) (44)
Mitogen-potentiating action and binding characteristics of insulin and insulin-like growth factors in Chinese hamster fibroblasts. (1983) (44)
The Na+/H+ exchanger is phosphorylated in human platelets in response to activating agents (1991) (43)
ERK1 plays a critical protective role against N‐methyl‐D‐aspartate‐induced retinal injury (2008) (43)
Role of cytoplasmic domain of the Na+/H+ exchanger in hormonal activation. (1993) (42)
Hirudin, a probe to analyze the growth-promoting activity of thrombin in fibroblasts; reevaluation of the temporal action of competence factors. (1982) (42)
Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Rapid desensitization of phosphocholine-specific (PC) phospholipase D but sustained activity of PC-phospholipase C. (1992) (41)
Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2). (1993) (40)
cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells. (1991) (40)
Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway (2008) (40)
ERK1 is important for Th2 differentiation and development of experimental asthma (2012) (39)
Evidence for a GTP‐binding protein coupling thrombin receptor to PIP2‐phospholipase C in membranes of hamster fibroblasts (1987) (39)
Activation of HIF‐1α in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway (2009) (39)
Growth factor requirements of Chinese hamster lung fibroblasts in serum free media: high mitogenic action of thrombin. (1981) (39)
Complete Structure of an Increasing Capillary Permeability Protein (ICPP) Purified from Vipera lebetina Venom (2002) (38)
Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells (2016) (38)
Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice (2015) (38)
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. (2007) (38)
Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia (2015) (38)
Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation (2015) (38)
ARDent about acetylation and deacetylation in hypoxia signalling. (2006) (37)
Emergence of hamster fibroblast tumors in nude mice—evidence for in vivo selection leading to loss of growth factor requirement (1981) (37)
Effects of Cytotoxic Necrotizing Factor 1 and Lethal Toxin on Actin Cytoskeleton and VE-Cadherin Localization in Human Endothelial Cell Monolayers (1999) (37)
G protein-controlled signal transduction pathways and the regulation of cell proliferation. (1992) (37)
The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization. (1988) (37)
Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts. (1986) (37)
The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma (2018) (37)
Cloning of the human genomic amiloride-sensitive Na+/H+ antiporter gene, identification of genetic polymorphisms, and localization on the genetic map of chromosome 1p. (1990) (37)
Molecular biology and hormonal regulation of vertebrate Na+/H+ exchanger isoforms. (1994) (36)
A genetic approach to the role of energy metabolism in the growth of tumor cells: Tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration (1981) (36)
Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts (1980) (36)
Molecular Properties, Kinetics and Regulation of Mammalian Na+/H+ Exchangers (1994) (36)
Inducible expression of a MAP kinase phosphatase‐3‐GFP chimera specifically blunts fibroblast growth and ras‐dependent tumor formation in nude mice (2004) (35)
Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction (2015) (35)
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. (1990) (35)
Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging (2018) (34)
Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts. (1988) (34)
Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3. (1993) (34)
MAP kinases: activation, subcellular localization and role in the control of cell proliferation. (1993) (34)
When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy. (2005) (33)
An Arresting Start for MAPK (2000) (33)
The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53–p21 axis (2012) (33)
ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1 (2015) (33)
ERK1 and ERK2 are required for radial glial maintenance and cortical lamination (2010) (33)
Transmembrane signalling pathways initiating cell growth in fibroblasts. (1988) (33)
Cell surface glycoproteins and malignant transformation. (1979) (31)
Endothelin stimulates mitogen-activated protein kinase activity in mesangial cells through ETA. (1994) (31)
"Carrier activation" and glucose transport in Chinese hamster fibroblasts. (1978) (30)
Cutting Edge: Extracellular Signal-Related Kinase Is Not Required for Negative Selection of Developing T Cells1 (2009) (30)
Positron emission tomography/computed tomography imaging of residual skull base chordoma before radiotherapy using fluoromisonidazole and fluorodeoxyglucose: potential consequences for dose painting. (2012) (29)
Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system (2012) (29)
Tumor hypoxia and metabolism -- towards novel anticancer approaches. (2013) (29)
Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs (2017) (28)
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteins in Rous sarcoma virus-transformed chick embryo fibroblasts ( glucose starvation / membrane proteins ) (28)
Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence. (1990) (28)
The Na+:H+ antiport in cancer. (1986) (28)
Structure-activity analysis of synthetic α-thrombin-receptor-activating peptides (1993) (28)
Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells. (1991) (27)
Physical Interactions and Functional Coupling between Daxx and Sodium Hydrogen Exchanger 1 in Ischemic Cell Death* (2008) (26)
Characterization of the neuropilin‐1 promoter; gene expression is mediated by the transcription factor Sp1 (2003) (26)
MOLECULAR ASPECTS OF THE STRUCTURE AND MECHANISM OF THE VOLTAGE‐DEPENDENT SODIUM CHANNEL * (1980) (25)
Functional expression of the human growth factor activatable Na+/H+ antiporter (NHE-1) in baculovirus-infected cells. (1991) (25)
Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript. (1991) (25)
Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1. (1993) (24)
The directionality of locomotion of mouse fibroblasts. Role of cell adhesiveness. (1979) (24)
Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma (2019) (24)
Hypoxia-induced autophagy is mediated through the HIF-induction of BNIP3 and BNIP3L via their BH3-domains (2008) (24)
Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin (2018) (24)
Utilization of gluconate by Escherichia coli. Uptake of D-gluconate by a mutant impaired in gluconate kinase activity and by membrane vesicles derived therefrom. (1974) (24)
Down-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomerase. (1982) (24)
Affinity labeling of high-affinity alpha-thrombin binding sites on the surface of hamster fibroblasts. (1985) (23)
Study of MAPK signaling using knockout mice. (2004) (23)
Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters* (2016) (23)
Analysis of growth factor “relaxation” in chinese hamster lung fibroblasts required for tumoral expression (1983) (23)
Functional Expression and Growth Factor Activation of an Epitope-Tagged p 44 Mitogen-Activated Protein Kinase , p 44 mapk (23)
HIF-1 : régulateur central de l’hypoxie (2002) (23)
Early and late mitogenic events induced by FGF on bovine epithelial lens cells are not triggered by hydrolysis of polyphosphoinositides. (1987) (22)
Le métabolisme des hexuronides et des hexuronates chez Escherichia coli K 12: Aspects physiologiques et génétiques de sa régulation (1974) (22)
Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients. (2013) (22)
Chapter 12 Na+-H+ Exchange and Growth Control in Fibroblasts: A Genetic Approach (1986) (21)
Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells. (2008) (20)
Molecular cloning of the growth-factor-activatable human Na+/H+ antiporter. (1988) (20)
Functional expression of Ca2+ ‐mobilizing α‐thrombin receptors in mRNA‐injected Xenopus oocytes (1990) (20)
The mammalian Na+/H+ exchanger gene family--initial structure/function studies. (1993) (20)
ERK1 Regulates the Hematopoietic Stem Cell Niches (2012) (20)
Thrombin-induced protein phosphorylation in resting platelets and fibroblasts: evidence for common post-receptor molecular events. (1983) (19)
'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives. (2022) (19)
Integration of a ‘proton antenna’ facilitates transport activity of the monocarboxylate transporter MCT4 (2017) (19)
Thrombin and Its Receptor in Growth Control a (1995) (18)
Phosphorylation of Na(+)-H+ antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells. (1993) (18)
Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability. (2010) (18)
Hypoxia in health and disease. (2016) (17)
Etude du rameau dégradatif commun des hexuronates chez Escherichia coli K 12 (1971) (17)
NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner (2021) (17)
A transport system for 2-keto-3-deoxy-D-gluconate uptake in Escherichia coli K12. Biochemical and physiological studies in whole cells. (1973) (17)
[MAP kinase module: role in the control of cell proliferation]. (1995) (17)
Signal transduction in hamster fibroblasts overexpressing the human EGF receptor. (1989) (17)
Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype. (1992) (16)
Glucose-induced O ( 2 ) consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic Beta-cells . " (2019) (16)
Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown. (1990) (16)
Molecular Studies of Members of the Mammalian Na+/H+ Exchanger Gene Family (1996) (16)
Structure, Function and Growth Factor Activation of the Na+/H+ Antiporter (NHE1) (1992) (16)
Mitogenic Effects of Fibroblast Growth Factors in Cultured Fibroblastsa (1991) (15)
Sugar transport in chick embryo cardiac cells in culture: analysis by countertransport, relationship to phosphorylation and effect of glucose starvation. (1980) (15)
ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB (2017) (15)
Hypoxic mitochondria: accomplices in resistance. (2011) (15)
Signal transduction. An arresting start for MAPK. (2000) (15)
Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis (2020) (14)
Hif-2alpha mediates UV induced apoptosis through a novel ATF3 dependent death pathway (2008) (14)
Structure, function, and regulation of vertebrate Na+/H+ exchangers. (1993) (14)
α-Thrombin receptors and growth signaling (1993) (14)
Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer (2020) (14)
Endothelin stimulates mitogen-activated protein kinase p42 activity through the phosphorylation of the kinase in rat mesangial cells. (1993) (14)
Étude du rameau dégradatif commun des hexuronates chez Escherichia coli K 12 (1971) (14)
CHAPTER 23 – G Proteins in Growth Factor Action (1990) (13)
Evidence that hamster fibroblast tumors emerge in nude mice through the process of two in vivo selections leading to growth factor “relaxation” and to immune resistance (1982) (13)
Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts. (1990) (12)
From Malignant Progression to Therapeutic Targeting: Current Insights of Mesothelin in Pancreatic Ductal Adenocarcinoma (2020) (12)
Conventional techniques to monitor mitochondrial oxygen consumption. (2014) (12)
Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response (2021) (12)
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter (1990) (12)
HIF1α est une nouvelle cible du facteur de transcription MITF : Implication de la cascade AMPc-MITF-HIF1α dans le développement des melanomas (2006) (12)
Epithelial localization of a reptilian Na+/H+ exchanger homologous to NHE-1. (1997) (11)
Growth factor-stimulated protein synthesis is inhibited by sodium orthovanadate. (2001) (11)
Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas (2017) (10)
Use of tritium-labeled precursors to select mutants. (1987) (10)
Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells. (2019) (10)
RT-PCR method to quantify vascular endothelial growth factor expression. (2001) (10)
Na/H Exchange activities in NHE1-transfected OK-cells: cell polarity and regulation (1993) (10)
A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells (2021) (9)
Differential tumorigenicity of growth factor-dependent versus -independent CCL39 lung fibroblast lines in nude mice. (1986) (9)
Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts. (1989) (9)
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity (2018) (9)
Genetic approach to structure, function, and regulation of the Na+/H+ antiporter. (1987) (9)
99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma (2019) (9)
Independent activation of endogenous p21‐activated protein kinase‐3 (PAK3) and JNK by thrombin in CCL39 fibroblasts (2000) (9)
Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients (2020) (9)
The role of intracellular pH in ligand internalization (1986) (9)
Preparation Microbiologique Du 2‐CETO‐3‐Desoxy‐D‐Gluconate 1‐14C ou U‐14C (1973) (8)
Molecular biology and hormonal regulation of vertebrate Na+/H+ exchanger isoforms. (1994) (8)
Mitogenic effects of fibroblast growth factors in cultured fibroblasts. Interaction with the G-protein-mediated signaling pathways. (1991) (8)
AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts (2015) (8)
Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS (2020) (8)
Gene disruption using zinc finger nuclease technology. (2014) (7)
Correction for Savadjiev et al., Heart wall myofibers are arranged in minimal surfaces to optimize organ function (2012) (7)
Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase (2020) (7)
[Regulation of the Hypoxia-Inducible Factor-1alpha (HIF-1alpha): a breath of fresh air in hypoxia research]. (2004) (6)
Localisation génétique de mutations 2-céto-3-désoxy-6-P-gluconate aldolase négatives chez E. coli K 12 (2004) (6)
Biomarkers in cancer management: a crucial bridge toward personalized medicine (2004) (5)
Co‐culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia (2020) (5)
Hypoxia protects against the cell death triggered by oxovanadium–galactomannan complexes in HepG2 cells (2019) (5)
Phosphorylation of the Growth-Factor Activatable Na+/H+ Antiporter: A Mechanism of Regulation (1991) (5)
Biochemical studies of the structure, mechanism and differentiation of the voltage-sensitive sodium channel (1980) (5)
Alpha-thrombin receptor and MAP kinases in the control of cell growth. (1993) (4)
Hypoxia and hypoxia‐inducible factors promote the development of neointimal hyperplasia in arteriovenous fistula (2021) (4)
Targeting amino acids transporters (SLCs) to starve cancer cells to death. (2019) (4)
Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis (1978) (4)
ERK 1 and ERK 2 present functional redundancy in tetrapods despite higher evolution rate of ERK 1 (2015) (4)
Structure-activity analysis of synthetic alpha-thrombin-receptor-activating peptides. (1993) (4)
Stimulation of Phosphatidylcholine Breakdown by Thrombin and Carbachol but Not by Tyrosine Kinase Receptor Ligands in Cells Transfected with M 1 Muscarinic Receptors (2001) (4)
[2-Keto-3-deoxy-gluconate transport system in E. coli K 12: map location of a structural gene and of its operator]. (1973) (4)
[Study of the common degradative pathway of hexuronates in Escherichia coli K 12. Purification, properties and individuality of 2-keto-3-deoxy-D-gluconnokinase]. (1971) (4)
Enzyme-Linked Immunosorbent Assay for Pharmacological Studies Targeting Hypoxia-Inducible Factor 1α (2005) (3)
Na+,K+,H+ AND PROTEIN PHOSPHORYLATION IN THE GROWTH FACTOR-INDUCED G0/G1 TRANSITION IN FIBROBLASTS (1982) (3)
[A common pathway for hexouronate degradation in Escherichia coli K 12. Induction mechanism of 2-keto-3-deoxy-gluconate metabolizing enzymes]. (1972) (3)
[Map location of 2-keto-3-deoxy-6-P-gluconate aldolase negative mutations in E. coli K12]. (1971) (3)
Functional expression of Ca2(+)-mobilizing alpha-thrombin receptors in mRNA-injected Xenopus oocytes. (1990) (3)
Hypoxia and Tumour Angiogenesis (2008) (3)
Mutations affectant le gène de structure de la 2-céto-3-désoxy-6-P-gluconate aldolase chez E. coli K 12 (1972) (3)
Biochemical titration of glycogen in vitro. (2013) (3)
Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma (2020) (3)
Abstract 3225: Growth inhibition of glycolytic tumors by targeting basigin/lactate-H+ symporters (MCTs): Metformin sensitizes MCT inhibition (2012) (2)
Genetic Disruption of the γ-Glutamylcysteine Ligase in PDAC Cells Induces Ferroptosis-Independent Cell Death In Vitro without Affecting In Vivo Tumor Growth (2022) (2)
Système de transport du 2-céto-3-désoxy-gluconate chez E. coli K12: localisation d'un gène de structure et de son opérateur (1973) (2)
Le récepteur de la thrombine et ses implications dans la prolifération des cellules vasculaires (1993) (2)
Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism (2019) (2)
Gene Transfer in Vascular Cells Using an Engineered Na-H Exchanger (NHE1) as a Selectable Marker. (1999) (2)
Oxygen tension regulates pancreatic beta-cell differentiation through HIF1  (2009) (2)
The silencing approach of the hypoxia-signaling pathway. (2007) (2)
Highlights of the European Association of Cancer Research (EACR 2008). (2009) (2)
Progressive relaxation of Go-arrest controls and altered responsiveness to insulin, EGF and thrombin in CCL39 lung fibroblasts over-expressing myc and ras oncogenes. (1988) (2)
3 Hypoxia signaling — impact on tumor metabolism, cell survival & cell death (2006) (2)
Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice (2017) (1)
Local mitochondrial-endolysosomal microfusion cleaves the (2015) (1)
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1alpha. (2005) (1)
The monocarboxylate transporter 1 (MCT1) and Hypoxia-induced MCT4 are key targets promoting tumor cell survival (2008) (1)
[Physiologic and genetic control of metabolism of 2-keto-3-deoxy-gluconate in E. coli K 12. Regulon kdg]. (1972) (1)
[The common degradative pathway for hexuronates in Escherichia coli K 12. Purification, properties and individuality of 2-keto-3-deoxy-6-phospho-D-gluconate aldolase]. (1971) (1)
Dualité fonctionnelle des anhydrases carboniques CAIX et CAXII : impact pronostique chez les patients atteints d’un carcinome pulmonaire non à petite cellules (CPNPC) (2011) (1)
Hypoxie et croissance tumorale (2004) (1)
Metabolic Rewiring toward Oxidative Phosphorylation Disrupts Intrinsic Resistance to Ferroptosis of the Colon Adenocarcinoma Cells (2022) (1)
Réponse dynamique des anhydrases carboniques IX et XII pendant la réoxygénation tumorale : impact sur l’agressivité tumorale et la dualité pronostique chez les patients atteints d’un carcinome pulmonaire non à petite cellules (CPNPC) (2012) (1)
Neural-specific inactivation of ERK2 in mice causes abnormal laminar formation in the cerebral cortex (2009) (0)
328 Tumour metabolic adaptation to hypoxic and acidic stress (2010) (0)
Chapter 16 The vertebrate Na+/H+ exchangers structure, expression and hormonal regulation (1996) (0)
TRANSMEMBRANE SIGNALLING PATHWAYS CONTROLLING CELL GROWTH (1989) (0)
Hypoxia, Autophagy and Tumour Metabolism (2008) (0)
531 Synergy between HIF1a and LOX is critical for tumour progression (2010) (0)
Molecular structure and regulation of the Na+/H+ exchangers (1999) (0)
METAMORPHOSES (2000) (0)
Marie-Fran9oise Dubois, VanTrungNguyen, (1994) (0)
Cell Growth Signaling in Fibroblasts: the Role of G-Proteins (1990) (0)
Hypoxia and Metabolism Regulation in Chordomas: Correlation Between Biology and Clinical Features for Potential Targeted Therapy (2015) (0)
Hypoxic Stress Signaling (2006) (0)
Imaging intracellular ERK1 dynamics upon stimulation of the MAPK signaling pathway (2005) (0)
Hypoxia-induced BNIP3 reduces proliferation of colon carcinoma cells through downregulation of ERK1/2 (2008) (0)
Isolation ofaChinese hamster fibroblast mutantdefective in hexose transport andaerobic glycolysis: Itsusetodissect themalignant phenotype (1980) (0)
François Lavelle (1943–2018) (2018) (0)
Professor Ernesto Carafoli, a scientific monument in biochemistry and biology of calcium signalling. (2022) (0)
Activation Extracellular Signal-regulated Kinase via Listeria monocytogenes Autophagy of TLR 2 and RIP 2 Pathways Mediate Immunology : (2011) (0)
Abstract 5426: Down-regulation of cancer metabolism enhances radiosensitivity by impairing the heat shock response (2022) (0)
O49 L’oxygène contrôle la différenciation des cellules bêta pancréatiques via HIF1alpha (2010) (0)
The great joy of a BBRC editor. (2019) (0)
protein kinase as a converging targetfordifferent growthfactor signaling pathways: useofpertussis toxin as a discrimination factor (1991) (0)
6 Hypoxia signalling, metabolism and cancer (2009) (0)
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters (2015) (0)
SubsetsOpposites: Erk Direction of CD4 T Cell (2012) (0)
Regulation of the Na7H exchanger isoform NHE1: Role of phosphorylation (2010) (0)
Hypoxia protects against the cell death triggered by oxovanadium–galactomannan complexes in HepG2 cells (2019) (0)
Alpha-thrombin receptors and growth signaling. (1993) (0)
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity (2018) (0)
Molecular Genetics of the Mammalian Na+/H+ Antiporter (2018) (0)
L05.01 HYPOXIA SIGNALING, PHI REGULATION & TUMOR METABOLISM. NOVEL THERAPEUTIC APPROACHES (2013) (0)
Genetic dissection of growth factor-mediated controls of cell proliferation as an approach to analyze the process of tumor progression. (1985) (0)
ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1 (2015) (0)
Erk2 is a critical regulator of spontaneous osteochondromas (P1016) (2013) (0)
Commentarydynamics in cancer (2010) (0)
[Tumor hypoxic and nutritional stress. New anticancer treatment]. (2010) (0)
MAP Kinase Cascade and the Control of Cell Proliferation (1993) (0)
Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation (2015) (0)
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages (2018) (0)
P39 01 TP – USE OF GLYCOLYSIS-DEFICIENT CELLS TO EXAMINE THE RELATIONSHIP BETWEEN LACTATE PRODUCTION AND TUMOUR ACIDITY (1991) (0)
NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner (2021) (0)
Contents, Vol. 4, 1994 (1994) (0)
Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging (2018) (0)
Dissecting the pro-tumoural role of the essential amino-acid transporter complex CD98/LAT1 (2016) (0)
Role of cell surface carbohydrates and proteins in cell behavior: Studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant (cell surface glycoproteins/membrane mutant/growth control/phenotypic transformation/3T3 Balb cells) (2016) (0)
Molecular cloning andexpression ofa cDNA encoding therabbit ileal villus cell basolateral membraneNa+/H+ exchanger (1991) (0)
G-protein signalling pathways and the control of cell proliferation (1990) (0)
HIF-1 links bacterial infection, inflammation and cancer (2008) (0)
Dysregulation of ERK signaling in CD4-expressing cells induces osteochondromas (IRC8P.441) (2015) (0)
Transduction of Mitogenic Signals in Normal and Malignant Cells Impaired in Na+:H+ Antiport-Mediated pH Regulation (2020) (0)
Growth-Promoting Activity of Thrombin in Fibroblasts: Temporal Action and Early Biochemical Events in the G0 → G1 Transition (1983) (0)
Abstract C282: The carcinogen cadmium is a HIF1A stabilizer that reduces HIF1 activity through cytosolic sequestration of HIF1A within K63-linked ubiquitinated aggregates. (2013) (0)
Cell mutants as a tool to study malignant transformation of fibroblasts. (1980) (0)
Mitogenicity of sea anemone toxin its relation to the tetrodo toxin sensitive sodium channel present in fibroblasts (1980) (0)
Implication of MAP kinase and STRESS kinases pathways in the régulation of vascular endothelial growth factor (VEGF) (1996) (0)
p42/p44 MAP kinase (Erk) - Control of spatio-temporal activity (2002) (0)
SubsetsPolar Opposites: Erk Direction of CD4 T Cell (2012) (0)
[Enzymatic synthesis of 2-keto-3-deoxy-D-gluconate]. (1970) (0)
Erratum for Brahimi-Horn et al., “Local Mitochondrial-Endolysosomal Microfusion Cleaves the Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia” (2022) (0)
Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors. (2021) (0)
Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway (2002) (0)
[Metabolism of hexuronides and hexuronates in Escherichia coli K12: physiologic and genetic aspects of its regulation]. (1974) (0)
Death Hydrogen Exchanger 1 in Ischemic Cell Coupling between Daxx and Sodium Physical Interactions and Functional Mechanisms of Signal Transduction : (2007) (0)
Efficacité et toxicité d’une réirradiation stéréotaxique ablative dans les cancers bronchiques pulmonaires non à petites cellules en récidive locale (2012) (0)
[Induced biosynthesis of the 2 last enzymes of hexuronate degradative sequence in Escherichia coli K 12]. (1970) (0)
[Production of 2-keto-3-deoxy-6-phosphogluconate by a mutant of Escherichia coli K 12]. (1970) (0)
[Accumulation of D glucuronate by the transport system of 2-keto-3-deoxy-D-gluconate in Escherichia coli K 12]. (1972) (0)
[Mutations of the structural gene of 2-keto-3-desoxy-6-P-gluconate aldolase in E. coli K 12]. (1972) (0)
The HIF-induced carbonic anhydrase IX and XII regulate intracellular pH promoting tumor survival in a hypoxic and acidic microenvironment (2008) (0)
High sensitivity in quantitative, competitive RT-PCR using QIAGEN ® enzymes* (2002) (0)
Intracellular signals in the mitogenic response (1988) (0)
Modulations of intra and extracellular pH in tumor variants defective in either respiration or glycolysis , observed by in vivo MRS (2009) (0)
This information is current as Subsets Polar Opposites : Erk Direction of CD 4 T Cell (2012) (0)
has the mechanism by which stabilization of HIF-1 ot leads to initiation of the transcription of target genes involved in growth of blood vessels. (2001) (0)
CO22 - L’invalidation de erk1 protège de l’obésité et de l’insulinorésistance (2008) (0)
Le stress hypoxique et nutritionnel tumoral. Nouvelles approches anticancer (2010) (0)
Role of the ERK signaling in the developing cerebral cortex (2010) (0)
P208 - Dual regulation of steroidogenesis and angiogenesis through mrna destabilization triggered by the zinc finger protein tis11b (2004) (0)
L'hypoxie tumorale et le métabolisme - vers de nouvelles approches anticancéreuses (2013) (0)
O89 L’invalidation de la MAP kinase Erk1 augmente la capacité oxydative du muscle squelettique (2009) (0)
Abstract 5011: Potential tumor suppressor role of PHD2 : functional study of mutations identified in germline DNA of patients with congenital polycythemia with or without paraganglioma (2010) (0)
L'angiogenèse hypoxique : approches thérapeutiques en cancérologie (2003) (0)
A crosstalk between HIF-1a and LOX in the tumor microenvironment (2008) (0)
Table of Contents (1991) (0)
L'échangeur Na+/H+ : caractérisation et rôle physiologique (1987) (0)
Pharmacological inhibition of the amino-acid transporter LAT1 demonstrates in vitro anti-neoplastic activity towards medulloblastoma (2018) (0)
Facteurs de croissance hématopoïétiques. Transmission des signaux de prolifération. Discussion (1994) (0)
Glucose depletion accounts fortheinduction oftwotransformation- sensitive membraneproteins inRoussarcoma virus-transformed chickembryofibroblasts (1977) (0)
Glucose transport and glycolytic mutants of fibroblasts their use in analyzing the regulation and the role of these functions in the control of cell division (1980) (0)
MDCK cells phenotype and morphogenesis in transdifferentiated Loss of active MEK1-ERK1/2 restores epithelial (2005) (0)
Growth factor activated MAP kinases: Mechanism of nuclear translocation and role in growth control (1997) (0)
Genetic manipulation of proton transport mechanisms generates modulations of intra and extracellular pH and growth characteristics in tumors (2011) (0)
Subject Index, Vol. 4, 1994 (1994) (0)
Abstract 880: Genetic ablation of the cystine transporter xCT in pancreatic ductal adenocarcinoma inhibits mTORC1, growth, survival and tumor formation: Implications for potentiating chemosensitivityviaerastin (2019) (0)

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