James Champoux
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Most Influential Person Now
American microbiologist
James Champoux's AcademicInfluence.com Rankings
James Champouxbiology Degrees
Biology
#10326
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#13647
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Microbiology
#689
World Rank
#761
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Biology
James Champoux's Degrees
- Bachelors Microbiology University of California, Berkeley
- Masters Microbiology Stanford University
Why Is James Champoux Influential?
(Suggest an Edit or Addition)According to Wikipedia, James J. Champoux was an American microbiologist who worked at University of Washington and an Elected Fellow of the American Association for the Advancement of Science. Education He earned his B.S. at University of Washington and his Ph.D. at Stanford University.
James Champoux's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DNA topoisomerases: structure, function, and mechanism. (2001) (2425)
- Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. (1998) (794)
- A model for the mechanism of human topoisomerase I. (1998) (656)
- DNA topoisomerase I is involved in both repression and activation of transcription (1993) (367)
- An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay). (1972) (270)
- The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily (2001) (264)
- Human DNA topoisomerase I: relaxation, roles, and damage control (2005) (210)
- Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages* (2005) (204)
- Deletions affecting the transposition of an antibiotic resistance gene. (1977) (204)
- SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity (2005) (190)
- Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination. (1985) (189)
- The Domain Organization of Human Topoisomerase I (*) (1996) (182)
- Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA. (1984) (177)
- Proteins that affect DNA conformation. (1978) (153)
- The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. (2002) (145)
- RNase H activity: structure, specificity, and function in reverse transcription. (2008) (140)
- DNA is linked to the rat liver DNA nicking-closing enzyme by a phosphodiester bond to tyrosine. (1981) (138)
- Biochemical and Biophysical Analyses of Recombinant Forms of Human Topoisomerase I (*) (1996) (136)
- Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. (2000) (134)
- Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription. (1997) (133)
- Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? (2007) (128)
- Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin. (1992) (123)
- Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures. (2002) (116)
- Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis* (1999) (116)
- The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I. (1989) (116)
- Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide. (2003) (115)
- Reconstitution of human topoisomerase I by fragment complementation. (1997) (113)
- Purification and characterization of the DNA untwisting enzyme from rat liver. (1976) (97)
- Preferential binding of human topoisomerase I to superhelical DNA. (1995) (92)
- Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA. (1977) (92)
- 6 Roles of Ribonuclease H in Reverse Transcription (1993) (80)
- Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription (2009) (78)
- Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme. (1976) (78)
- Plus-strand priming by Moloney murine leukemia virus. The sequence features important for cleavage by RNase H. (1989) (77)
- Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. (1999) (76)
- 6 Mechanistic Aspects of Type-I Topoisomerases (1990) (73)
- TOPOISOMERASES AND THE SWIVEL PROBLEM (1980) (73)
- Mechanism of the reaction catalyzed by the DNA untwisting enzyme: attachment of the enzyme to 3'-terminus of the nicked DNA. (1978) (67)
- RNA-primed initiation of Moloney murine leukemia virus plus strands by reverse transcriptase in vitro (1984) (66)
- The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA. (2006) (65)
- Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase (1992) (64)
- The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase. (1993) (62)
- Mapping in vivo topoisomerase I sites on simian virus 40 DNA: asymmetric distribution of sites on replicating molecules (1989) (61)
- Structural insights into the function of type IB topoisomerases. (1999) (58)
- The role of Moloney murine leukemia virus RNase H activity in the formation of plus-strand primers (1987) (58)
- Domains of human topoisomerase I and associated functions. (1998) (55)
- Mechanism of RNA primer removal by the RNase H activity of avian myeloblastosis virus reverse transcriptase (1984) (55)
- The effect of salt on the binding of the eucaryotic DNA nicking-closing enzyme to DNA and chromatin. (1981) (54)
- Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1. (2011) (54)
- Characterization of RNA Strand Displacement Synthesis by Moloney Murine Leukemia Virus Reverse Transcriptase* (1998) (51)
- DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate. (1981) (49)
- Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing. (1984) (46)
- Strand displacement synthesis capability of Moloney murine leukemia virus reverse transcriptase (1994) (46)
- Properties of strand displacement synthesis by Moloney murine leukemia virus reverse transcriptase: mechanistic implications. (1998) (46)
- Plus-strand origin for human immunodeficiency virus type 1: implications for integration (1990) (45)
- Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. (2004) (44)
- Renaturation of complementary single-stranded DNA circles: complete rewinding facilitated by the DNA untwisting enzyme. (1977) (42)
- Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex. (1980) (42)
- Topoisomerase I is preferentially associated with isolated replicating simian virus 40 molecules after treatment of infected cells with camptothecin (1988) (41)
- DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein (2003) (39)
- Synthesis of murine leukemia virus plus strong stop DNA initiates at a unique site. (1982) (39)
- Pausing during Reverse Transcription Increases the Rate of Retroviral Recombination (2006) (38)
- Reconstitution of Enzymatic Activity by the Association of the Cap and Catalytic Domains of Human Topoisomerase I* (2002) (37)
- Priming of superhelical SV40 DNA by Escherichia coli RNA polymerase for in vitro DNA synthesis. (1975) (35)
- The effects of camptothecin on the reaction and the specificity of the wheat germ type I topoisomerase. (1989) (35)
- Sequence, Distance, and Accessibility Are Determinants of 5′-End-directed Cleavages by Retroviral RNases H* (2006) (35)
- Sugar conformations at hybrid duplex junctions in HIV-1 and Okazaki fragments. (1993) (35)
- Polypurine Tract Primer Generation and Utilization by Moloney Murine Leukemia Virus Reverse Transcriptase* (1999) (34)
- The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I* (2004) (34)
- Recognition of internal cleavage sites by retroviral RNases H. (2004) (34)
- Structure‐Based Analysis of the Effects of Camptothecin on the Activities of Human Topoisomerase I (2000) (33)
- RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity (1996) (30)
- The Role of Histidine 632 in Catalysis by Human Topoisomerase I* (2001) (29)
- Mechanism of catalysis by eukaryotic DNA topoisomerase I. (1994) (29)
- The use of DNA and RNA oligonucleotides in hybrid structures with longer polynucleotide chains to probe the structural requirements for moloney murine leukemia virus plus strand priming. (1994) (28)
- The DNA untwisting enzyme from Saccharomyces cerevisiae. Partial purification and characterization. (1978) (27)
- Multiple forms of rat liver type I topoisomerase. (1983) (26)
- The topography of lambda DNA: polyriboguanylic acid binding sites and base composition. (1972) (24)
- DNA topoisomerase I-mediated nicking of circular duplex DNA. (2001) (24)
- Cutting of M13mp7 phage DNA and excision of cloned single-stranded sequences by restriction endonucleases. (1983) (24)
- Cleavage Specificities of Moloney Murine Leukemia Virus RNase H Implicated in the Second Strand Transfer During Reverse Transcription (*) (1995) (24)
- The role of single-strand breaks in the catenation reaction catalyzed by the rat type I topoisomerase. (1986) (23)
- A High-Frequency Secondary Event During the 2004 Parkfield Earthquake (2007) (22)
- Topoisomerase I is preferentially associated with normal SV40 replicative intermediates, but is associated with both replicating and nonreplicating SV40 DNAs which are deficient in histones (1992) (21)
- Specific Cleavages by RNase H Facilitate Initiation of Plus-Strand RNA Synthesis by Moloney Murine Leukemia Virus (2003) (20)
- Effects of Unpaired Nucleotides within HIV-1 Genomic Secondary Structures on Pausing and Strand Transfer* (2005) (20)
- Sequence-specific binding of DNA by the Moloney murine leukemia virus integrase protein (1990) (19)
- Assaying DNA topoisomerase I relaxation activity. (2001) (19)
- Type IA DNA topoisomerases: Strictly one step at a time (2002) (19)
- Kinetics and mechanism of addition of acids to olefins. III. Addition of hydrogen chloride to 2-methyl-1-butene, 2-methyl-2-butene, and isoprene in nitromethane (1969) (18)
- Studies on the regulation and specificity of the DNA-untwisting enzyme. (1979) (17)
- Purification of baculovirus-expressed human DNA topoisomerase I. (1999) (17)
- Characterization of the replicative intermediates of polyoma virus. (1974) (17)
- Analysis of the biased distribution of topoisomerase I break sites on replicating simian virus 40 DNA. (1993) (17)
- The majority of simian immunodeficiency virus/mne circle junctions result from ligation of unintegrated viral DNA ends that are aberrant for integration. (1993) (16)
- The Cap Region of Topoisomerase I Binds to Sites near Both Ends of Simian Virus 40 T Antigen (2003) (16)
- DNA structural features that lead to strand breakage by eukaryotic type-I topoisomerase. (1984) (16)
- Structural alterations in the DNA ahead of the primer terminus during displacement synthesis by reverse transcriptases. (2001) (16)
- Single Unpaired Nucleotides Facilitate HIV-1 Reverse Transcriptase Displacement Synthesis through Duplex RNA* (2004) (15)
- DNA strand breakage by wheat germ type 1 topoisomerase. (1984) (14)
- Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA (2009) (14)
- Preferred Sequences within a Defined Cleavage Window Specify DNA 3′ End-directed Cleavages by Retroviral RNases H* (2009) (13)
- The Sequence and Orientation of Transcription in Bacteriophage λ (1970) (12)
- Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo. (2007) (12)
- A first view of the structure of a type IA topoisomerase with bound DNA. (2002) (11)
- Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H. (2010) (11)
- Interaction of the DNA untwisting enzyme with the SV40 nucleoprotein complex. (1978) (11)
- Arylstibonic acids: novel inhibitors and activators of human topoisomerase IB. (2008) (10)
- Requirements for DNA Unpairing during Displacement Synthesis by HIV-1 Reverse Transcriptase* (2004) (10)
- A cellular single-stranded DNA-dependent ATPase associated with simian virus 40 chromatin. (1983) (6)
- Moloney murine leukemia virus IN protein from disrupted virions binds and specifically cleaves its target sequence in vitro. (1991) (6)
- Assays for the preferential binding of human topoisomerase I to supercoiled DNA. (2009) (6)
- Crystal Structure of a Human Tyrosyl-DNA Phosphodiesterase (Tdp1)-Tungstate Complex (2003) (4)
- Crystal structure of human tyrosyl-DNA phosphodiesterase (Tdp1) in complex with vanadate, DNA and a human topoisomerase I-derived peptide (2003) (2)
- Human DNA Topoisomerase I: Structure, Enzymology and Biology (2012) (2)
- Efficient misincorporation by avian myeloblastosis virus reverse transcriptase in the presence of a single deoxyribonucleoside triphosphate. (1984) (1)
- The Cap Region of Topoisomerase I Binds to Sites near Both Ends of Simian Virus 40 T Antigen (2003) (1)
- HUMAN TOPOISOMERASE I/DNA COMPLEX (1998) (1)
- TheRoleofMoloneyMurineLeukemiaVirusRNaseH Activity intheFormation ofPlus-Strand Primers (1987) (0)
- Purification and preliminary crystallization experiments on DNA-binding proteins human topoisomerase 1 and HIV-2 integrase (1993) (0)
- Human topoisomerase I (Topo70) double mutant K532R/Y723F (2003) (0)
- CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX (2000) (0)
- TOPOISOMERASE I/DNA COMPLEX (1998) (0)
- THE RELATIONSHIP BETWEEN MUTATIONS OF PHE61 OF THE HIV‐1 REVERSE TRANSCRIPTASE FINGER SUBDOMAIN AND DISPLACEMENT SYNTHESIS.: 343 (2004) (0)
- The crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTG (2004) (0)
- Specific Cleavages by RNase H Facilitate Initiation of Plus-Strand RNA Synthesis by Moloney Murine Leukemia Virus (2003) (0)
- Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTA (2004) (0)
- Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octapeptide KLNYYDPR, and tetranucleotide AGTT. (2004) (0)
- Binding ofDNA bytheMoloneyMurine Leukemia VirusIntegrase Protein (1990) (0)
- Progress in the structure determination of a human topoisomerase I–DNA complex (1996) (0)
- HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX (1998) (0)
- DNA Topoisomerases: Type I (2004) (0)
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