James E. Crowe
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Pediatrician
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James E. Crowe's Degrees
- Doctorate Medicine University of North Carolina at Chapel Hill
- PhD Microbiology and Immunology University of North Carolina at Chapel Hill
Why Is James E. Crowe Influential?
(Suggest an Edit or Addition)According to Wikipedia, James Earl Crowe Jr. is an American immunologist and pediatrician as well as Professor of Pediatrics and Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center. Education and career James Crowe was born August 14, 1961, in Nashville, Tennessee. He received his B.S. from Davidson College in 1983. Then went on to medical school at the University of North Carolina, Chapel Hill, completing his M.D. in 1987. He continued at the University of North Carolina for his pediatric internship and residency from 1987 to 1990. Following his medical training, Crowe moved to the U.S. National Institutes of Health in 1990 serving first as a Medical Staff Fellow from 1990 to 1993 under Robert Chanock and Brian R. Murphy, then as a Senior Research Investigator in the Laboratoy of Infectious Diseases from 1993 to 1995. He then completed a clinical fellowship in pediatric infectious diseases at Vanderbilt Medical Center before being appointed to the faculty as an assistant professor in the Department of Pediatrics in 1996. Crowe was subsequently promoted to associate professor in 2001, and to full professor in the Department of Pediatrics in 2004. He is currently in Ann Scott Carell Chair at the Vanderbilt University Medical Center, an endowed professorship as well as Director of the Vanderbilt Vaccine Center. In 2014, Crowe was elected to the National Academy of Medicine.
James E. Crowe's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Potently neutralizing and protective human antibodies against SARS-CoV-2 (2020) (824)
- Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. (2004) (771)
- Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies (2021) (702)
- Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus (2010) (586)
- Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition (2020) (566)
- Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition (2020) (465)
- Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19 (2020) (448)
- Proof of principle for epitope-focused vaccine design (2014) (446)
- Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors (2008) (429)
- Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions (2012) (355)
- Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice (2016) (338)
- An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies (2022) (251)
- Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes (2010) (244)
- Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein (2020) (241)
- Towards a consensus on datasets and evaluation metrics for developing B‐cell epitope prediction tools (2007) (241)
- The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience. (2006) (232)
- Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection (2021) (221)
- Mxra8 is a receptor for multiple arthritogenic alphaviruses (2018) (204)
- Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers (2015) (204)
- An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies (2021) (203)
- Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children. (1997) (203)
- High frequency of shared clonotypes in human B cell receptor repertoires (2019) (201)
- Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies. (2005) (197)
- A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin (2011) (192)
- Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein (2020) (186)
- A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins (2015) (183)
- Radiology of Syndromes, Metabolic Disorders, and Skeletal Dysplasias (1990) (181)
- Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity. (1992) (176)
- Respiratory syncytial virus vaccine development. (2001) (172)
- Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein (2021) (170)
- A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. (2005) (167)
- A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. (2018) (162)
- A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface (2014) (155)
- Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein (2021) (153)
- Respiratory Syncytial Virus Induces Host RNA Stress Granules To Facilitate Viral Replication (2010) (153)
- Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection (2016) (149)
- Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults. (2005) (149)
- Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection (2018) (148)
- Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2 (2008) (148)
- A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction (2009) (146)
- Dengue Viruses Are Enhanced by Distinct Populations of Serotype Cross-Reactive Antibodies in Human Immune Sera (2014) (143)
- Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress (2015) (140)
- Human Respiratory Syncytial Virus Nucleoprotein and Inclusion Bodies Antagonize the Innate Immune Response Mediated by MDA5 and MAVS (2012) (139)
- Single molecule–sensitive probes for imaging RNA in live cells (2009) (138)
- Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail (2021) (137)
- Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection (2011) (136)
- Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans (2017) (136)
- A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface (2019) (135)
- An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines. (1994) (134)
- An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies. (2008) (133)
- Specificity for human hemoglobin enhances Staphylococcus aureus infection. (2010) (133)
- The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein (2013) (129)
- A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin (2013) (127)
- Effect of Zinc Salts on Respiratory Syncytial Virus Replication (2004) (126)
- Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site (2013) (126)
- Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus (2015) (124)
- A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection (2019) (123)
- Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. (1994) (122)
- A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis. (2012) (117)
- Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells (2003) (116)
- Influence of maternal antibodies on neonatal immunization against respiratory viruses. (2001) (115)
- Population-Based Incidence of Human Metapneumovirus Infection among Hospitalized Children (2010) (115)
- Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization. (1995) (113)
- Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus (1995) (113)
- Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes (2012) (113)
- In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains (2021) (112)
- Prevalence of Reovirus-Specific Antibodies in Young Children in Nashville, Tennessee (2005) (112)
- Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics (2015) (111)
- Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody (2015) (108)
- Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. (2015) (107)
- A human antibody against Zika virus crosslinks the E protein to prevent infection (2017) (104)
- Passively Acquired Antibodies Suppress Humoral But Not Cell-Mediated Immunity in Mice Immunized with Live Attenuated Respiratory Syncytial Virus Vaccines (2001) (104)
- Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus. (2005) (103)
- A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees. (1994) (103)
- Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes. (2005) (102)
- Human metapneumovirus infection in children hospitalized for wheezing (2005) (102)
- The Cotton Rat (Sigmodon hispidus) Is a Permissive Small Animal Model of Human Metapneumovirus Infection, Pathogenesis, and Protective Immunity (2005) (100)
- A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV. (1993) (100)
- Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance. (2017) (99)
- Immunology of viral respiratory tract infection in infancy. (2003) (96)
- Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses (2009) (95)
- Isolation of Dengue Virus-Specific Memory B Cells with Live Virus Antigen from Human Subjects following Natural Infection Reveals the Presence of Diverse Novel Functional Groups of Antibody Clones (2014) (94)
- Human Germline Antibody Gene Segments Encode Polyspecific Antibodies (2013) (94)
- A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses (2016) (94)
- A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3 (2000) (92)
- Addition of a Missense Mutation Present in the L Gene of Respiratory Syncytial Virus (RSV) cpts530/1030 to RSV Vaccine Candidate cpts248/404 Increases Its Attenuation and Temperature Sensitivity (1999) (92)
- RhoA Interacts with the Fusion Glycoprotein of Respiratory Syncytial Virus and Facilitates Virus-Induced Syncytium Formation (1999) (91)
- Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis. (1994) (90)
- Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies (2016) (89)
- Human Metapneumovirus as a Major Cause of Human Respiratory Tract Disease (2004) (88)
- Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections (2016) (87)
- Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies (2016) (86)
- In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains. (2021) (83)
- Capturing the Spectrum of Interaction Effects in Genetic Association Studies by Simulated Evaporative Cooling Network Analysis (2009) (82)
- Human Metapneumovirus Fusion Protein Vaccines That Are Immunogenic and Protective in Cotton Rats (2006) (82)
- Venezuelan Equine Encephalitis Virus Replicon Particles Encoding Respiratory Syncytial Virus Surface Glycoproteins Induce Protective Mucosal Responses in Mice and Cotton Rats (2007) (81)
- Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses (2012) (81)
- HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. (2018) (80)
- High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals (2012) (80)
- Coronavirus infection and hospitalizations for acute respiratory illness in young children (2009) (79)
- Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence (2011) (78)
- The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans (2022) (77)
- The Pediatric Burden of Human Coronaviruses Evaluated for Twenty Years (2009) (77)
- Feature Selection using a Random Forests Classifier for the Integrated Analysis of Multiple Data Types (2006) (75)
- Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection (2018) (75)
- Genetic basis for adverse events after smallpox vaccination. (2008) (75)
- Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years (2009) (75)
- A New Quaternary Structure Epitope on Dengue Virus Serotype 2 Is the Target of Durable Type-Specific Neutralizing Antibodies (2015) (75)
- Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics. (2013) (73)
- Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination (2009) (73)
- SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies (2021) (71)
- Infant and Adult Human B Cell Responses to Rotavirus Share Common Immunodominant Variable Gene Repertoires 1 (2003) (69)
- An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by several therapeutic monoclonal antibodies (2021) (69)
- Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication (2011) (69)
- Current approaches to the development of vaccines against disease caused by respiratory syncytial virus (RSV) and parainfluenza virus (PIV). A meeting report of the WHO Programme for Vaccine Development. (1995) (69)
- Comparison of Subgenomic and Total RNA in SARS-CoV-2-Challenged Rhesus Macaques (2021) (69)
- A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo (2007) (68)
- Broad dengue neutralization in mosquitoes expressing an engineered antibody (2019) (68)
- Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design. (2017) (68)
- Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire (2012) (68)
- Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains (2022) (66)
- Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection. (2018) (66)
- Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site (2012) (65)
- Respiratory Syncytial Virus Regulates Human MicroRNAs by Using Mechanisms Involving Beta Interferon and NF-κB (2012) (64)
- Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity (2014) (64)
- A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein (2017) (64)
- Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity (2012) (63)
- Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies. (2015) (63)
- Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis (2017) (63)
- Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8+ Lung-Resident Memory T Cells. (2019) (63)
- Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. (2009) (61)
- Immune responses of infants to infection with respiratory viruses and live attenuated respiratory virus candidate vaccines. (1998) (61)
- Discovering naturally processed antigenic determinants that confer protective T cell immunity. (2013) (61)
- Generation of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles. (2003) (61)
- Acute bowing fractures of the forearm in children: a frequently missed injury. (1977) (61)
- Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization (2020) (60)
- A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA (2018) (60)
- Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trial. (2004) (60)
- Gold nanorod vaccine for respiratory syncytial virus (2013) (59)
- VH1–46 Is the Dominant Immunoglobulin Heavy Chain Gene Segment in Rotavirus-Specific Memory B Cells Expressing the Intestinal Homing Receptor α4β71 (2005) (59)
- Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action (2017) (59)
- The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein (1997) (59)
- Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail (2021) (59)
- Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate. (1996) (59)
- Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence. (2016) (58)
- Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody (2017) (58)
- The Human Polymeric Immunoglobulin Receptor Facilitates Invasion of Epithelial Cells by Streptococcus pneumoniae in a Strain-Specific and Cell Type-Specific Manner (2002) (58)
- A Critical Phenylalanine Residue in the Respiratory Syncytial Virus Fusion Protein Cytoplasmic Tail Mediates Assembly of Internal Viral Proteins into Viral Filaments and Particles (2012) (57)
- Machine learning competition in immunology - Prediction of HLA class I binding peptides. (2011) (57)
- A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope (2021) (56)
- Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses (2012) (56)
- Human Antibody Responses to Mature and Immature Forms of Viral Envelope in Respiratory Syncytial Virus Infection: Significance for Subunit Vaccines (1999) (56)
- H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. (2016) (56)
- BROADLY NEUTRALIZING ANTIBODIES FROM HUMAN SURVIVORS TARGET A CONSERVED SITE IN THE EBOLA VIRUS GLYCOPROTEIN HR2/MPER REGION (2018) (56)
- Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein (2018) (56)
- Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells. (2007) (55)
- Adverse events after smallpox immunizations are associated with alterations in systemic cytokine levels. (2004) (55)
- Live subgroup B respiratory syncytial virus vaccines that are attenuated, genetically stable, and immunogenic in rodents and nonhuman primates. (1996) (54)
- Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell (2021) (54)
- Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. (2018) (53)
- Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus (2017) (53)
- Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation. (2008) (52)
- Cytokine expression patterns associated with systemic adverse events following smallpox immunization. (2006) (52)
- Identification of an H-2Db-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus (2005) (52)
- Independent Structural Domains in Paramyxovirus Polymerase Protein* (2012) (52)
- Differential Regulation of Granzyme and Perforin in Effector and Memory T Cells following Smallpox Immunization1 (2005) (51)
- Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore (2013) (51)
- Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals (2020) (50)
- A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes. (1995) (50)
- Identification of a novel human leucocyte antigen‐A*01‐restricted cytotoxic T‐lymphocyte epitope in the respiratory syncytial virus fusion protein (2003) (50)
- Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein. (1998) (49)
- Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses. (2018) (49)
- An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats (2008) (47)
- Transforming Growth Factor Beta Is a Major Regulator of Human Neonatal Immune Responses following Respiratory Syncytial Virus Infection (2010) (46)
- Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination (2016) (46)
- Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope (2019) (46)
- An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody (2011) (46)
- Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions (2021) (46)
- Evaporative cooling feature selection for genotypic data involving interactions (2007) (45)
- Immunodominance of the VH1–46 Antibody Gene Segment in the Primary Repertoire of Human Rotavirus-Specific B Cells Is Reduced in the Memory Compartment through Somatic Mutation of Nondominant Clones1 (2008) (45)
- Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques (2017) (45)
- Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine (2010) (44)
- Tissue-Specific Regulation of CD8+ T-Lymphocyte Immunodominance in Respiratory Syncytial Virus Infection (2006) (44)
- Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms (2017) (43)
- Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection (2020) (42)
- Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. (2019) (42)
- Maturation-Induced Cloaking of Neutralization Epitopes on HIV-1 Particles (2011) (42)
- Identification of Residues in the Human Respiratory Syncytial Virus Fusion Protein That Modulate Fusion Activity and Pathogenesis (2014) (41)
- Respiratory Syncytial Virus Nucleoprotein-Specific Cytotoxic T-Cell Epitopes in a South African Population of Diverse HLA Types Are Conserved in Circulating Field Strains (2003) (41)
- Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity (2015) (41)
- Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site (2015) (41)
- Regulatory T cell expression of CLA or α4β7 and skin or gut acute GVHD outcomes (2011) (41)
- Functional Maturation of the Human Antibody Response to Rotavirus1 (2008) (41)
- Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody (2016) (40)
- Deep sequencing and human antibody repertoire analysis. (2016) (40)
- Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface. (2017) (39)
- Pulmonary blastoma in a child. (1979) (39)
- Identification of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus. (2005) (38)
- The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations. (2009) (38)
- Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. (2020) (38)
- Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes. (2005) (38)
- Intermittent testicular torsion in the pediatric patient: sonographic indicators of a difficult diagnosis. (2013) (37)
- Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection (2020) (37)
- A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus (2021) (36)
- Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies (2016) (36)
- The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. (2018) (35)
- Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics (2020) (35)
- Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice. (2019) (35)
- In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model (2018) (34)
- Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody. (2019) (34)
- Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein (2016) (34)
- Tissue-Specific Expressed Antibody Variable Gene Repertoires (2014) (34)
- CHLAMYDIA INFECTION (2001) (34)
- Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein (2018) (34)
- The Transmembrane Domain of the Respiratory Syncytial Virus F Protein Is an Orientation-Independent Apical Plasma Membrane Sorting Sequence (2005) (33)
- Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein. (2014) (33)
- Pseudovirion Particles Bearing Native HIV Envelope Trimers Facilitate a Novel Method for Generating Human Neutralizing Monoclonal Antibodies Against HIV (2010) (33)
- Respiratory Syncytial Virus Assembles into Structured Filamentous Virion Particles Independently of Host Cytoskeleton and Related Proteins (2012) (32)
- Human monoclonal antibody Fab fragments cloned from combinatorial libraries: potential usefulness in prevention and/or treatment of major human viral diseases. (1993) (32)
- Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1 (2016) (31)
- Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences (2015) (31)
- Cellular immune responses to diluted and undiluted aventis pasteur smallpox vaccine. (2006) (31)
- Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection* (2015) (31)
- Combining Single RNA Sensitive Probes with Subdiffraction-Limited and Live-Cell Imaging Enables the Characterization of Virus Dynamics in Cells (2013) (30)
- Prophylactic and therapeutic testing of Nicotiana-derived RSV-neutralizing human monoclonal antibodies in the cotton rat model (2013) (29)
- Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses. (2013) (29)
- High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires (2019) (29)
- Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins (2018) (29)
- Broadly Neutralizing Antibodies Targeting New Sites of Vulnerability in Hepatitis C Virus E1E2 (2019) (28)
- CD40-ligand in primate cardiac allograft and viral immunity (2001) (28)
- Unusual Features of Vaccinia Virus Extracellular Virion Form Neutralization Resistance Revealed in Human Antibody Responses to the Smallpox Vaccine (2012) (27)
- Examination of a Fusogenic Hexameric Core from Human Metapneumovirus and Identification of a Potent Synthetic Peptide Inhibitor from the Heptad Repeat 1 Region (2006) (27)
- Passive IgA monoclonal antibody is no more effective than IgG at protecting mice from mucosal challenge with respiratory syncytial virus. (1999) (27)
- Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains (2019) (27)
- Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals (2021) (27)
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- Respiratory Syncytial Virus (2016) (0)
- Quantum dots provide a faster, more sensitive method for detecting respiratory viral infections (2005) (0)
- Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein (2018) (0)
- Human orthopoxvirus antibodies and methods of use therefor (2017) (0)
- Chapter 155 – B-Cell Development (2004) (0)
- crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab (2020) (0)
- Reply to Schlapbach et al (2011) (0)
- crystal structure of monoclonal antibody MR78 Fab (2017) (0)
- Faculty Opinions recommendation of Engineering microRNA responsiveness to decrease virus pathogenicity. (2008) (0)
- The crystal structure of bovine ultralong antibody BOV-2 (2019) (0)
- following Smallpox Immunization Perforin in Effector and Memory T Cells Differential Regulation of Granzyme and (2017) (0)
- Faculty Opinions recommendation of Immune recognition of a human renal cancer antigen through post-translational protein splicing. (2004) (0)
- Exposure to Family Members: Infections and Recent Live Vaccinations (2013) (0)
- Viral Pneumonia (2012) (0)
- Human Monoclonal Antibodies to Escherichia coli Outer Membrane Protein A Porin Domain Cause Aggregation but Do Not Alter In Vivo Bacterial Burdens in a Murine Sepsis Model (2022) (0)
- Structural and functional analysis of cooperativity in a potent human antibody cocktail against Ebola virus (2020) (0)
- Antibody Response to Rotavirus Functional Maturation of the Human (2008) (0)
- ConvergenceSequence Divergence and Interclonal Repertoires Diversify by B Cell Intraclonal Epitope-Specific Human Influenza Antibody (2011) (0)
- Faculty Opinions recommendation of Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing. (2002) (0)
- Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies (2022) (0)
- Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods (2022) (0)
- Variable Gene Repertoires Rotavirus Share Common Immunodominant Infant and Adult Human B Cell Responses to (2003) (0)
- EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 (2016) (0)
- Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses (2021) (0)
- EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 (2016) (0)
- The crystal structure of bovine ultralong antibody BOV-3 (2019) (0)
- Fab fragments of chikungunya virus neutralizing human monoclonal antibody 5M16 (2015) (0)
- Respiratory Syncytial Virus: A Nanotechnology Driven Approach Toward Vaccine Development (2010) (0)
- Interaction Between Post-Transplant Diabetes Mellitus and Regulatory T Cell Phenotype (2011) (0)
- The immunogenetics of smallpox vaccination. Commentary (2007) (0)
- Compositions de vaccins a base de virus respiratoire syncytial attenue (1993) (0)
- Universal Flu Primum non nocere (2014) (0)
- Mechanisms of Zika virus antibody neutralization (2018) (0)
- Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk (2019) (0)
- Faculty Opinions recommendation of Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. (2009) (0)
- Improved Visualization of the Lumbar Spine and Sacrum in Pediatric Patients by Use of the Pneumatic Compression Paddle (1979) (0)
- Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation (2016) (0)
- Monoclonal Antibodies for Infectious Diseases: Why We are on the Threshold of a Major Therapeutic Revolution (2017) (0)
- Receptor Binding Site H1N1 Influenza Virus Hemagglutinin Antibody Recognition of the Pandemic (2013) (0)
- Faculty Opinions recommendation of Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. (2004) (0)
- Crystal structure of the anti-RSV F Fab 14N4 (2016) (0)
- Crystal structure of human Fab 14N4 in complex with post-fusion RSV F (2016) (0)
- ZIKV-specific CD8 T cell immunity in humans is affected by DENV pre-exposure (2018) (0)
- Author Correction: A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus (2022) (0)
- Mapping Epitopes of Pan‐Ebolavirus Antibodies From Human Survivors (2016) (0)
- Cornea Farinata and other Variants (2009) (0)
- The crystal structure of a MR78 mutant (2018) (0)
- The crystal structure of bovine ultralong antibody BOV-5 (2019) (0)
- Pediatric Skeletal Radiology (1993) (0)
- Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab (2015) (0)
- A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in rhesus macaques (2021) (0)
- Cryo-EM structure of Dengue virus serotype 3 at 37 degrees C (2015) (0)
- Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants (2022) (0)
- Heterosubtypic human antibody response to influenza H7N9 in survivors of natural infection (2020) (0)
- crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain (2020) (0)
- Faculty Opinions recommendation of Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. (2005) (0)
- 1408. Enterovirus D68 RNA Visualized in the Anterior Horn of the Spinal Cord of a Pediatric Patient with Flaccid Paralysis (2020) (0)
- Introduction (2004) (0)
- Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics (2020) (0)
- Human antibody specificities that confer protective immunity to poxvirus infections (VAC11P.1109) (2015) (0)
- #16: Enterovirus D68 Visualized in the Anterior Horn of the Spinal Cord of a Pediatric Patient with Flaccid Paralysis (2021) (0)
- Handbook of Pediatric Imaging (1992) (0)
- Crowdsourcing Immunity (2013) (0)
- Crystal structure of RSV F in complex with human antibody hRSV90 (2017) (0)
- Naturally processed HLA class I-restricted epitopes inform targets of protective CD8+ T cell-mediated immunity (113.11) (2012) (0)
- Computational epitope mapping of class I fusion proteins using Bayes classification (2022) (0)
- Ebola virus glycoprotein in complex with EBOV-520 Fab (2020) (0)
- Crystal structure of human anti staphylococcus aureus antibody STAU-281 Fab in complex with IsdB NEAT2 domain (2020) (0)
- #31: Children with Invasive S. aureus Infection Produce Broadly Neutralizing Antibodies Against Distantly Related Variants of the Cytotoxin LukAB (2021) (0)
- Logistic curve analysis used to calculate IC50 values for neutralization assays. (2020) (0)
- nd Outcome of Symptomatic Upper and Lower espiratory Tract Infections by Respiratory Viruses n Adult Recipients of Hematopoietic Stem Cell ransplants for Hematologic Malignancies (2005) (0)
- Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 (2015) (0)
- A Clinical Isolate Strain of Respiratory Syncytial Virus (RSV) Causes Airway Obstruction and Histopathology in Mice Similar to Severe RSV Disease in Infants (2008) (0)
- α 4 β 7 ± Regulatory T Cells (Tregs) at Engraftment Predict Long-Term Graft-Versus-Host Disease (GVHD) Outcomes. (2009) (0)
- Metabolic Complications Precede Alloreactivity and are Characterized by Changes in Th1/Th17 Immunity (2018) (0)
- Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1 (2020) (0)
- SARS-CoV-2 human monoclonal antibody therapy (2020) (0)
- Retraction for hinge determines (2015) (0)
- Contributors (2008) (0)
- Faculty Opinions recommendation of Low-coverage vaccination strategies for the conservation of endangered species. (2006) (0)
- Correction for “ Combined TRPC 3 and TRPC 6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy (2014) (0)
- Anti Rotavirus Antibody (2013) (0)
- Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation. (2015) (0)
- Even old foes can learn sweet new tricks. (2022) (0)
- Emergency plain film radiology of the nontraumatized patient with altered consciousness. (1978) (0)
- The Molecular Tool‐Kit of Viral Hemorrhagic Fevers (2015) (0)
- Viral Pneumonia (2006) (0)
- Corrigendum: Convergent antibody responses are associated with broad neutralization of hepatitis C virus (2023) (0)
- Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. (2023) (0)
- Potently neutralizing human monoclonal antibodies against the zoonotic pararubulavirus Sosuga virus (2022) (0)
- Responses to the Smallpox Vaccine Resistance Revealed in Human Antibody (2014) (0)
- Tribute to David T. Karzon, MD and Robert M. Chanock, MD (2011) (0)
- The cryoEM structures of immature and mature Zika virus and of mature Zika virus complexed with a human monoclonal antibody (2017) (0)
- The crystal structure of bovine ultralong antibody BOV-7 (2019) (0)
- The vaccine compositions containing the attenuated respiratory syncytial virus (1993) (0)
- Current Understanding of Humoral Immunity to Enterovirus D68. (2018) (0)
- Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibody AZD8895 (2021) (0)
- Crystal Structure of an influenza A hemagglutinin antibody Fab variant CH67:1203d4 chimera (2019) (0)
- Faculty Opinions recommendation of Stable antibody expression at therapeutic levels using the 2A peptide. (2005) (0)
- EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 (2016) (0)
- New-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Celltransplant Is Initiated By Insulin Resistance, Not Iatrogenesis (2019) (0)
- A method for detecting respiratory syncytial virus (2002) (0)
- CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143. (2020) (0)
- The Transmembrane Domain of the Respiratory Syncytial Virus F Protein Is an Orientation-Independent Apical Plasma Membrane Sorting Sequence (2006) (0)
- Crystal structure of Hendra receptor binding protein head domain in complex with human neutralizing antibody HENV-32 (2020) (0)
- Current Understanding of Humoral Immunity to Enterovirus D68. (2018) (0)
- CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP (2020) (0)
- Faculty Opinions recommendation of Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120. (2004) (0)
- II of the Envelope Protein Unique Cross-Reactive Epitope on the bc Loop of Domain Virus-Specific Monoclonal Antibody 1 C 19 Reveals a The Potent and Broadly Neutralizing Human Dengue 2013 (2015) (0)
- Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires (2020) (0)
- Enterovirus D68 in complex with human monoclonal antibody EV68-159 (2020) (0)
- #91: Human Antibodies Neutralize Enterovirus D68 and Protect Against Infection and Paralytic Disease (2021) (0)
- Antiviral protection by antibodies targeting the glycan cap of Ebola virus glycoprotein requires activation of the complement system (2023) (0)
- Early Th1 Immunity Decreases Acute Graft-Versus-Host Disease and Impairs Graft-Versus-Leukemia Effect after Allogeneic Hematopoietic Cell Transplantation (2014) (0)
- Shared VH1-46 antibody gene usage in pemphigus vulgaris predicts antibody cross-reactivity to desmoglein 3 and rotavirus VP6 (HUM1P.271) (2015) (0)
- Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain (2020) (0)
- Gastrointestinal Radiology in Pediatrics (1975) (0)
- CD 154 blockade spares secondary immunity to influenza in primates (2004) (0)
- Contributors (2006) (0)
- Primary Hepatic Leiomyosarcoma: Case Report and Review of the Literature: 727 (2010) (0)
- Human Monoclonal Antibodies to the Staphylococcus aureus Toxin LukAB have Distinct Mechanisms of Protection and Are Efficacious in vivo (2016) (0)
- E107 Complexity of human naïve B cell repertoires: The starting point for induction of neutralizing antibodies (2013) (0)
- crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab (2020) (0)
- STRUCTURAL ANALYSIS OF ROTAVIRUS ANTIGEN – ANTIBODY INTERACTIONS By Mohammed Sefiu Aiyegbo (2013) (0)
- Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C (2015) (0)
- The crystal structure of bovine ultralong antibody BOV-1 (2019) (0)
- Discovering protective T-cell responses by interrogating naturally processed antigenic determinants (2013) (0)
- Invited Research Highlight Contribution (2014) (0)
- Neutralization Fingerprinting Technology for Characterizing Polyclonal Antibody Responses to Dengue Vaccines (2021) (0)
- Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses (2012) (0)
- Cryo-EM structure of Dengue virus serotype 3 at 28 degrees C (2015) (0)
- Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein (2015) (0)
- Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures (2019) (0)
- This information is current as 3 and Rotavirus Antigen VP 6 DesmogleinPemphigus Vulgaris Autoantigen Determinants of VH 1-46 Cross-Reactivity to (2016) (0)
- Protein Coated Gold Nanorod Vaccines (2013) (0)
- Faculty Opinions recommendation of Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. (2002) (0)
- Faculty Opinions recommendation of Secondary replicative function of CD8+ T cells that had developed an effector phenotype. (2009) (0)
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