James E. Darnell | Academic Influence

James E. Darnell's AcademicInfluence.com Rankings

James E. Darnell

Biology

#634

World Rank

#1114

Historical Rank

#355

USA Rank

Cell Biology

#15

World Rank

#16

Historical Rank

#9

USA Rank

Molecular Biology

#89

World Rank

#92

Historical Rank

#55

USA Rank

Neuroscience

#112

World Rank

#119

Historical Rank

#49

USA Rank

biology Degrees

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Biology

James E. Darnell's Degrees

PhD Biochemistry University of Washington

Why Is James E. Darnell Influential?

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According to Wikipedia, James Edwin Darnell Jr. is an American biologist who made significant contributions to RNA processing and cytokine signaling and is author of the cell biology textbook Molecular Cell Biology. In 2004, he was elected a foreign member of the Royal Swedish Academy of Sciences. He became a member of the American Philosophical Society in 2013.

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James E. Darnell's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. (1994) (5910)
STATs and gene regulation. (1997) (4047)
Signalling: STATs: transcriptional control and biological impact (2002) (2995)
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation (1995) (2099)
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. (1994) (1988)
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. (1995) (1949)
Stat3 as an Oncogene (1999) (1767)
The role of STATs in transcriptional control and their impact on cellular function (2000) (1249)
Stat3 as an Oncogene (1999) (1215)
The JAK-STAT pathway at twenty. (2012) (1192)
Transcription factors as targets for cancer therapy (2002) (1114)
Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice (1996) (1106)
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors (1995) (1047)
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. (1990) (971)
Sedimentation characteristics of rapidly labelled RNA from HeLa cells. (1962) (919)
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. (1992) (856)
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions (1994) (829)
The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo (1994) (818)
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. (1993) (797)
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. (1992) (748)
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4 (1995) (729)
Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA (1998) (707)
Stat3 Activation Is Required for Cellular Transformation by v-src (1998) (704)
Signal Transduction and the Control of Gene Expression (2002) (697)
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. (1993) (681)
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. (1992) (631)
Variety in the level of gene control in eukaryotic cells (1982) (583)
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation (2015) (554)
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. (1996) (551)
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. (2003) (546)
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. (1994) (542)
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. (1995) (538)
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. (1992) (528)
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes (1989) (502)
Polyadenylic Acid Sequences: Role in Conversion of Nuclear RNA into Messenger RNA (1971) (487)
Two contact regions between Stat1 and CBP/p300 in interferon γ signaling (1996) (485)
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins (1993) (478)
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. (1988) (478)
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. (1991) (460)
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. (1995) (451)
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. (1990) (450)
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway (1995) (429)
Transcriptional control in the production of liver-specific mRNAs (1981) (427)
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. (1989) (421)
A transcriptional hierarchy involved in mammalian cell-type specification (1992) (418)
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways. (1993) (415)
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. (1990) (397)
Identification of a Stat Gene That Functions in Drosophila Development (1996) (396)
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins (1992) (381)
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. (1994) (380)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover (2017) (380)
POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA. (1963) (380)
Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing (1978) (373)
Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. (1994) (373)
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. (1997) (350)
Biogenesis of mRNA: Genetic Regulation in Mammalian Cells (1973) (338)
Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function. (1993) (334)
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. (1996) (330)
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. (1987) (328)
Cytoplasmic activation of GAF, an IFN‐gamma‐regulated DNA‐binding factor. (1991) (314)
Biogenesis and characterization of histone messenger RNA in HeLa cells. (1972) (313)
DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites. (1996) (313)
Validating Stat3 in cancer therapy (2005) (311)
Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function. (1972) (307)
Role of STAT2 in the alpha interferon signaling pathway (1995) (305)
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either (1990) (304)
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA. (1971) (303)
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes (1983) (298)
Implications of RNA-RNA splicing in evolution of eukaryotic cells. (1978) (292)
Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. (1963) (289)
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons (1991) (286)
Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells. (1965) (282)
Structural bases of unphosphorylated STAT1 association and receptor binding. (2005) (282)
Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. (1966) (278)
ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM. (1965) (271)
Structure of the amino-terminal protein interaction domain of STAT-4. (1998) (266)
Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences (1979) (260)
Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells (1992) (260)
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. (2001) (256)
Polyadenylic acid segment in mRNA becomes shorter with age. (1973) (246)
Speculations on the early course of evolution. (1986) (245)
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport (1985) (243)
The primary transcription unit of the mouse β-Major globin gene (1981) (243)
Characterization of a new low molecular weight RNA in HeLa cell ribosomes. (1968) (239)
The Significance of Tetramerization in Promoter Recruitment by Stat5 (1999) (235)
Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain* (1996) (234)
Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. (1995) (229)
Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation (1999) (228)
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. (1987) (227)
Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon- (*) (1996) (225)
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. (2006) (225)
The state of the STATs: recent developments in the study of signal transduction to the nucleus. (1997) (225)
Methylated, blocked 5 termini in HeLa cell mRNA. (1975) (223)
Ribonucleic acids from animal cells. (1968) (219)
Ser727‐dependent recruitment of MCM5 by Stat1α in IFN‐γ‐induced transcriptional activation (1998) (216)
Dependence of liver-specific transcription on tissue organization (1985) (210)
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. (1999) (209)
Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes. (1988) (206)
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex (1996) (204)
Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130 (1996) (200)
Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation (2004) (199)
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. (1995) (199)
Distribution of the mammalian Stat gene family in mouse chromosomes. (1995) (199)
Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate (1993) (197)
Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA. (1973) (189)
Synergistic interaction between interferon‐alpha and interferon‐gamma through induced synthesis of one subunit of the transcription factor ISGF3. (1990) (188)
The adsorption and early fate of purified poliovirus in HeLa cells. (1961) (188)
Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. (1966) (182)
Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway. (1998) (182)
THE TURNOVER OF NUCLEAR DNA-LIKE RNA IN HELA CELLS (1968) (182)
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds (1993) (181)
A simplified procedure for purification of large amounts of poliovirus: characterization and amino acid analysis of Type 1 poliovirus. (1960) (180)
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. (1996) (180)
Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. (1971) (178)
The initiation sites for RNA transcription in Ad2 DNA (1977) (178)
Regulation of the Primary Expression of the Early Adenovirus Transcription Units (1979) (177)
Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. (1993) (174)
A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes. (1988) (173)
The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells (1976) (173)
Transcriptional induction of two genes in human cells by beta interferon. (1984) (171)
Function of Stat2 protein in transcriptional activation by alpha interferon (1996) (169)
Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase (1997) (167)
The methylation of adenovirus-specific nuclear and cytoplasmic RNA. (1976) (163)
The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein (1996) (160)
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. (2005) (160)
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. (1986) (159)
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping of nascent RNA molecular labeled in isolated nuclei (1977) (159)
A CYTOPLASMIC STRUCTURE INVOLVED IN THE SYNTHESIS AND ASSEMBLY OF POLIOVIRUS COMPONENTS. (1964) (156)
Sindbis virus infection of chick and hamster cells: synthesis of virus-specific proteins. (1969) (156)
Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction. (1986) (153)
RNA synthesis in poliovirus-infected cells. (1963) (150)
Distribution of 5 s RNA in HeLa cells. (1967) (149)
The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. (1991) (148)
Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. (1994) (148)
Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. (1990) (146)
Aspects of the synthesis of poliovirus RNA and the formation of virus particles. (1966) (146)
Arrangement of specific oligonucleotides within poly(A) terminated HnRNA molecules (1974) (145)
Transcription units for mRNA production in eukaryotic cells and their DNA viruses. (1979) (144)
Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. (2006) (144)
The effects of methionine deprivation on ribosome synthesis in HeLa cells. (1967) (141)
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination (1983) (141)
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. (1994) (140)
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene (1991) (140)
A Drosophila PIAS homologue negatively regulates stat92E (2001) (138)
Transcriptional control of the mouse prealbumin (transthyretin) gene: both promoter sequences and a distinct enhancer are cell specific (1986) (138)
Methyl labeling of HeLa cell hnRNA: a comparison with mRNA (1976) (133)
Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. (1993) (133)
The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation. (1993) (133)
The addition of 5′ cap structures occurs early in hnRNA synthesis and prematurely terminated molecules are capped (1980) (131)
Posttranscriptional modulation of gene expression in cultured rat hepatocytes (1984) (131)
tRNA synthesis in HeLa cells: a precursor to tRNA and the effects of methionine starvation on tRNA synthesis. (1969) (130)
Lipid and protein organization in sindbis virus. (1971) (129)
Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-γ (2002) (129)
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation (1999) (128)
Identification of the membrane protein and "core" protein of Sindbis virus. (1968) (127)
Competition hybridization by "pre-saturation" of HeLa cell DNA. (1969) (127)
STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. (2003) (122)
DRB-induced premature termination of late adenovirus transcription (1978) (122)
Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products (1988) (121)
Ribosome formation in HeLa cells in the absence of protein synthesis. (1966) (117)
Persistence of liver-specific messenger RNA in cultured hepatocytes: different regulatory events for different genes (1987) (117)
Interactions of alpha‐ and gamma‐interferon in the transcriptional regulation of the gene encoding a guanylate‐binding protein. (1989) (116)
Virus-Specific Double-Stranded RNA in Poliovirs-Infected Cells (1964) (115)
SnapShot: JAK-STAT Signaling (2007) (114)
Transcriptional control in hepatocytes: a window on development. (1991) (113)
Epidermal growth factor-induced growth inhibition requires Stat1 activation. (1998) (113)
Double-stranded regions in heterogeneous nuclear RNA from Hela cells. (1972) (111)
Groups of adenovirus type 2 mRNA's derived from a large primary transcript: probable nuclear origin and possible common 3' ends (1978) (111)
The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. (1979) (111)
N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. (1979) (109)
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: Mapping by effects of ultraviolet irradiation (1977) (106)
Functional Importance of Stat3 Tetramerization in Activation of the α2-Macroglobulin Gene* (2001) (104)
The association of protein with the polyadenylic acid of HeLa cell messenger RNA: evidence for a "transport" role of a 75,000 molecular weight polypeptide. (1976) (104)
Effects of valine deprivation on ribosome formation in HeLa cells. (1969) (104)
Globin RNA transcription: A possible termination site and demonstration of transcriptional control correlated with altered chromatin structure (1982) (104)
In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3. (1995) (103)
Processing of adenovirus specific nuclear RNA during virus replication. (1972) (103)
Distribution of mRNA in the cytoplasmic polyribosomes of the HeLa cell. (1965) (102)
Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways (1989) (102)
Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene (1990) (102)
Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture. (2013) (100)
Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid (1982) (100)
Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis (1976) (99)
Ribosomal precursor particles in the HeLa cell nucleus. (1967) (99)
Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression (1994) (99)
STAT signaling is active during early mammalian development (1997) (98)
Carbohydrate content of the membrane protein of Sindbis virus. (1970) (98)
The effect of puromycin on intranuclear steps in ribosome biosynthesis. (1968) (97)
THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLS. (1964) (97)
Reflections on STAT3, STAT5, and STAT6 as fat STATs. (1996) (93)
5,6-Dichloro-1-Beta-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneous RNA chains in HeLa cells. (1976) (91)
Possible relationship of poly(A) shortening to mRNA turnover. (1975) (91)
Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. (1984) (90)
SV40-specific RNA in the nucleus and polyribosomes of transformed cells. (1970) (90)
The processing of RNA. (1983) (90)
The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites (1988) (89)
The time course of synthesis of poliovirus RNA. (1961) (88)
Gene expression during liver regeneration. (1984) (88)
A reinterpretation of the dimerization interface of the N‐terminal Domains of STATs (2003) (87)
Independent and Cooperative Activation of Chromosomal c-fos Promoter by STAT3* (2003) (87)
Liver-specific RNA metabolism in hepatoma cells: variations in transcription rates and mRNA levels (1985) (85)
Mapping of RNA initiation sites by high doses of uv irradiation: evidence for three independent promoters within the left 11% of the Ad-2 genome. (1979) (85)
Interferon-dependent transcriptional activation: signal transduction without second messenger involvement? (1990) (85)
Unique signal transduction of Eyk: constitutive stimulation of the JAK‐STAT pathway by an oncogenic receptor‐type tyrosine kinase. (1996) (84)
Entrance of mRNA into HeLa cell cytoplasm in puromycin-treated cells. (1965) (84)
Control of messenger RNA concentration by differential cytoplasmic half-life. Adenovirus messenger RNAs from transcription units 1A and 1B. (1981) (84)
Positive and negative regulatory elements in the mouse albumin enhancer. (1989) (84)
Dissociation Time from DNA Determines Transcriptional Function in a STAT1 Linker Mutant* (2002) (83)
Fetal and adult localization of C/EBP: evidence for combinatorial action of transcription factors in cell-specific gene expression. (1990) (83)
Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. (1998) (82)
Relationship of chain transcription to poly(A) addition and processing of hnRNA in HeLa cells. (1974) (80)
Poliovirus protein: source of amino acids and time course of synthesis. (1960) (80)
A JAK-STAT pathway regulates wing vein formation in Drosophila. (1996) (80)
Characterization of the poly(adenylic acid) regions and the adjacent nucleotides in heterogeneous nuclear ribonucleic acid and messenger ribonucleic acid from HeLa cells. (1973) (79)
Adenovirus-2 mRNA is transcribed as part of a high-molecular-weight precursor RNA. (1975) (78)
3'-Terminal addition to HeLa cell nuclear and cytoplasmic poly (A). (1977) (77)
Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. (1989) (77)
Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse β-major globin terminator element (1985) (76)
Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus. (1990) (74)
Secondary structure in heterogeneous nuclear RNA: involvement of regions from repeated DNA sites. (1974) (73)
Effect of p-fluorophenylalanine and puromycin on the replication of poliovirus. (1962) (73)
The absolute frequency of labeled N-6-methyladenosine in HeLa cell messenger RNA decreases with label time. (1978) (73)
Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression (1986) (70)
A correlation between the rate of poly(A) shortening and half-life of messenger RNA in adenovirus transformed cells. (1978) (70)
Nuclear RNA is spliced in the absence of poly(A) addition (1981) (70)
Presence of cell and virus specific sequences in the same molecules of nuclear RNA from virus transformed cells. (1971) (69)
Cells resistant to interferon are defective in activation of a promoter‐binding factor. (1988) (69)
The Linker Domain of Stat1 Is Required for Gamma Interferon-Driven Transcription (1999) (68)
One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes. (1988) (68)
Evidence that interaction of hepatocytes with the collecting (hepatic) veins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver (1991) (68)
Large heterogeneous nuclear ribonucleic acid has three times as many 5' caps as polyadenylic acid segments, and most caps do not enter polyribosomes (1981) (68)
Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse beta-globin (major) gene. (1984) (67)
Positional and developmental regulation of glutamine synthetase expression in mouse liver (1988) (66)
Early events in poliovirus infection. (1962) (64)
The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (1995) (64)
Pre-mRNA processing includes N6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics” (2018) (64)
Distinct Transcriptional Activation Functions of STAT1α and STAT1β on DNA and Chromatin Templates* (2003) (63)
A cell-specific enhancer of the mouse alpha 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites (1988) (63)
Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation. (1989) (63)
Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. (1987) (62)
The inhibition by DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells. (1976) (62)
Premature termination during adenovirus transcription (1979) (62)
Interferon induction of gene transcription analyzed by in vivo footprinting. (1992) (62)
Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA. (1991) (61)
Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion. (1989) (61)
Transcription units of adenovirus type 2. Termination of transcription beyond the poly(A) addition site in early regions 2 and 4. (1980) (60)
Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon gamma (1995) (59)
A COMPARISON BETWEEN HETEROGENEOUS NUCLEAR RNA AND POLYSOMAL MESSENGER RNA IN HELA CELLS BY RNA-DNA HYBRIDIZATION (1970) (59)
hnRNA in HeLa cells: Distribution of transcript sizes estimated from nascent molecule profile (1976) (57)
The basis for variation in susceptibility to poliovirus in HeLa cells. (1960) (57)
Early Ad-2 transcription units: only promoter-proximal RNA continues to be made in the presence of DRB. (1979) (57)
Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication. (1989) (57)
In vitro RNA-RNA splicing in adenovirus 2 mRNA formation. (1978) (57)
Chinese hamster polyadenylated messenger ribonucleic acid: relationship to non-polyadenylated sequences and relative conservation during messenger ribonucleic acid processing (1981) (56)
Multiple discrete sites for premature RNA chain termination late in adenovirus-2 infection: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. (1979) (56)
Short-lived messenger RNA in HeLa cells and its impace on the kinetics of accumulation of cytoplasmic polyadenylate. (1975) (56)
The interaction of poliovirus RNA with Escherichia coli ribosomes. (1963) (55)
Acquisition of antigens characteristic of adult pericentral hepatocytes by differentiating fetal hepatoblasts in vitro (1987) (52)
Fractionation of heterogeneous nuclear RNA: rates of hybridization and chromosomal distribution of reiterated sequences. (1970) (51)
The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein (1990) (51)
Phosphotyrosine signaling and the single cell:metazoan boundary. (1997) (49)
Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. (1993) (49)
Transcriptionally active Statl is required for the antiproliferative effects of both interferon a and interferon (2005) (49)
The distribution of rapidly hybridizing RNA sequences in heterogeneous nuclear RNA and mRNA from hela cells (1970) (49)
Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. (2002) (49)
Cycloheximide stimulates early adenovirus transcription if early gene expression is allowed before treatment (1983) (48)
Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters (1986) (46)
Mechanisms of liver-specific gene expression. (1992) (46)
The decrease in size and synthetic activity of poliovirus polysomes late in the infectious cycle. (1967) (45)
Evidence from UV transcription mapping in HeLa cells that heterogeneous nuclear RNA is the messenger RNA precursor. (1977) (45)
Occurrence of uridylate-rich oligonucleotide regions in heterogeneous nuclear RNA of HeLa cells. (1972) (45)
Short capped hnRNA precursor chains in HeLa cells: continued synthesis in the presence of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. (1980) (44)
Further Evidence That the Majority of Primary Nuclear RNA Transcripts in Mammalian Cells Do Not Contribute to mRNA (1982) (43)
The JAK-STAT pathway: summary of initial studies and recent advances. (1996) (42)
Rapid in vivo footprinting technique identifies proteins bound to the TTR gene in the mouse liver. (1991) (41)
Potential roles of Stat1 and Stat3 in cellular transformation. (1999) (41)
Essential factors in the kinetic analysis of RNA synthesis in HeLa cells (1977) (40)
Production of Viral mRNA in Adenovirus-Transformed Cells by the Post-Transcriptional Processing of Heterogeneous Nuclear RNA Containing Viral and Cell Sequences (1973) (40)
STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis (2008) (40)
RNA: Life's Indispensable Molecule (2011) (39)
Glucose and glutamine in poliovirus production by HeLa cells. (1958) (39)
ISGF3,thetranscriptional activator induced byinterferon a, consists ofmultiple interacting polypeptide chains (1990) (39)
Ribosomal RNA in the Developing Chick Embryo (1963) (39)
Transcription and accurate polyadenylation in vitro of RNA from the major late adenovirus 2 transcription unit (1982) (38)
ADSORPTION AND MATURATION OF POLIOVIRUS IN SINGLY AND MULTIPLY INFECTED HELA CELLS (1958) (38)
Addition of poly(A) to nuclear RNA occurs soon after RNA synthesis (1980) (38)
Amino Acid Residues Required for Physical and Cooperative Transcriptional Interaction of STAT3 and AP-1 Proteins c-Jun and c-Fos (2007) (38)
Transcriptional control in hepatocytes of normal and c14CoS albino deletion mice. (1992) (37)
Evidence from UV transcription mapping that late adenovirus type 2 mRNA is derived from a large precursor molecule (1978) (37)
Transcriptional stimulation by CaPO4-DNA precipitates. (1988) (36)
Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. (1991) (36)
Adenovirus type 2 mRNA in transformed cells: map positions and difference in transport time (1978) (36)
Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity (2015) (35)
Oligonucleotides in heterogeneous nuclear RNA: similarity of inverted repeats and RNA from repetitious DNA sites. (1978) (35)
Structural genes of the mouse major urinary protein are on chromosome 4 (1982) (34)
Studies on HeLa cell nuclear DNA-like RNA by RNA-DNA hybridization. (1967) (34)
Constitutively activated Stat 3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat 1 (2001) (34)
A CYTOPLASMIC PARTICULATE INVOLVED IN POLIOVIRUS SYNTHESIS. (1963) (33)
STAT3, HIF-1, glucose addiction and Warburg effect (2010) (33)
Transcription unit mapping in adenovirus: regions of termination (1986) (33)
Early capping of transcripts from the adenovirus major late transcription unit (1980) (32)
Studies on the Relationship of mRNA to Heterogeneous Nuclear RNA in Mammalian Cells (1970) (32)
Poly(A) in mRNA does not contribute to secondary structure necessary for protein synthesis. (1974) (31)
Induced transcription of the mouse β-globintranscription unit in erythroleukemia cells (1984) (28)
Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. (2003) (28)
Metabolism of mRNA from the transforming region of adenovirus 2. (1980) (28)
Content of N-6 methyl adenylic acid in heterogeneous nuclear and messenger RNA of HeLa cells (1977) (28)
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA (2004) (27)
Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells. (2009) (27)
Order of polyadenylic acid addition and splicing events in early adenovirus mRNA formation (1980) (26)
Variation in plaque-forming ability among parental and clonal strains of HeLa cells. (1959) (26)
Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4 (1992) (25)
Antiviral Response in Cells Containing Stat1 with Heterologous Transactivation Domains (2001) (25)
Mitochondrial protein synthesis in HeLa cells. (1974) (25)
Isolation and Characterization of the α1-Antitrypsin Gene of Mice (1986) (25)
Activator of Transcription 3 Transformation by Activated Signal Transducer and Cyclin D 1 Is Transcriptionally Regulated by and Required for Updated (2006) (24)
THE INCIDENCE AND PATHOGENESIS OF MYOCARDITIS IN RABBITS AFTER GROUP A STREPTOCOCCAL PHARYNGEAL INFECTIONS (1956) (24)
Mapping of RNA polymerase on mammalian genes in cells and nuclei. (1992) (23)
Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it. (1988) (23)
The JAK-STAT pathway at 30: Much learned, much more to do (2022) (23)
THE EFFECT OF CELL POPULATION DENSITY ON THE AMINO ACID REQUIREMENTS FOR POLIOVIRUS SYNTHESIS IN HELA CELLS (1959) (22)
The effect of neutral red on plaque formation in two virus-cell systems. (1958) (22)
A precise termination site in the mouse beta-major globin transcription unit. (1983) (21)
A COMPARISON OF THE HETEROGENEOUS NUCLEAR RNA OF HELA CELLS IN DIFFERENT PERIODS OF THE CELL GROWTH CYCLE (1970) (18)
A Description of Various Classes of RNA from HeLa Cells (1963) (18)
In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element (1989) (17)
DNase I-hypersensitive sites in the 5'-flanking region of the rat serum albumin gene: correlation between chromatin structure and transcriptional activity. (1986) (17)
The biosynthesis of poliovirus in cell cultures. (1960) (16)
Mechanisms of liver-specific gene expression (1992) (16)
Adenovirus Strand Nomenclature: a Proposal (1977) (15)
Reduced STAT3 activity in mice mimics clinical disease syndromes. (2005) (15)
Cellular promoters incorporated into the adenovirus genome. Effect of viral DNA replication on endogenous and exogenous gene transcription. (1987) (15)
The presence of N-formyl-methionyl-tRNA in HeLa cell mitochondria. (1969) (14)
Interferon research: impact on understanding transcriptional control. (2007) (14)
The JAK-STAT pathway at 20. (2012) (14)
Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. Time-course of induction and of changes in chromatin structure. (1984) (13)
The primary transcription unit of the mouse beta-major globin gene. (1981) (13)
The synthesis and processing of a nuclear RNA precursor to rat pregrowth hormone messenger RNA. (1979) (13)
Regulation of Hepatocyte‐specific Gene Expression (1989) (13)
An examination of the nuclear RNA of adenovirus-transformed cells. (1975) (12)
Hybridization of mRNA from adenovirus-transformed cells to segments of the adenovirus genome (1976) (12)
The origin of mRNA and the structure of the mammalian chromosome. (1973) (12)
Protein recognition: An SH2 domain in disguise (1999) (12)
Origin of mRNA in HeLa cells and the implications for chromosome structure. (1974) (11)
Effect of penicillin on group A streptococci in vivo in the absence of leucocytes. (1955) (11)
The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. (1989) (10)
Transiently and stably introduced CCAAT/enhancer-binding-protein genes are constitutively expressed in cultured cells. (1992) (10)
Hepatoma variants (C2) are defective for transcriptional and post‐transcriptional actions from both endogenous and viral genomes. (1987) (9)
Cardiac Lesions in Rabbits After Pharyngeal Infections with Group A Streptococci.∗ (1955) (8)
5' Caps in hnRNA: absence of m32,2,7G and size distribution of capped molecules. (1977) (7)
Differential accumulation of virus-specific RNA during the cell cycle of adenovirus-transformed rat embyro cells (1975) (7)
General virology. 2nd edition. (1967) (6)
Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. (1992) (6)
Rat growth hormone gene: intervening sequences separate the mRNA regions. (1979) (6)
The definition of transcription units for mRNA. (1978) (6)
E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning. (1999) (5)
Isolation and characterization of the alpha 1-antitrypsin gene of mice. (1986) (5)
A Hopscotch-chromatin connection (2006) (4)
A precise termn ation site in the mouse pmajor -globin transcription unit (4)
THE EFFECT OF PUROMYCIN ON INTRANUCLEAR STEPS IN RIBOSOME BIOSYNTHESIS (1968) (4)
Production of Streptococcal Infections in Pharynx of the Rabbit.∗ (1954) (3)
The surprises of mammalian molecular cell biology (2002) (3)
Ribonucleic acids from animal cells (1968) (3)
STEPS IN PROCESSING OF mRNA: IMPLICATIONS FOR GENE REGULATION (1979) (3)
Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813. (2011) (3)
Joys and Surprises of a Career Studying Eukaryotic Gene Expression (2013) (3)
Rate of synthesis and concentration of specific mRNA sequences in cultured Chinese hamster ovary cells compared to liver cells. (1980) (3)
RIBONUCLEIC ACID FROM ANIMAL CELLS the cellular (2)
Harry Eagle. (1970) (2)
For liver-enriched transcription factor (1991) (2)
A brief chronicle on Harry Eagle (1970) (2)
Reflections on STAT 3 , STAT 5 , and STAT 6 as fat STATs (2005) (2)
THE ROLE OF POLY(A) IN MAMMALIAN GENE EXPRESSION11This work was supported by grants from the National Institutes of Health (CA 16006-09) and the American Cancer Society (CD 123). (1982) (2)
Adenovirus Type2mRNA inTransformed Cells: Map Positions andDifference inTransport Time (1978) (1)
Positive and negative regulatory elements in the mouse albumin enhancer ( tissue-specific gene expression / transcription factors / negative regulation (1)
Mapping a mammalian mRNA cap site by restriction digestion of hybridized cDNA. (1985) (1)
Special Achienvement in Medical Science Award. The surprises of mammalian molecular cell biology. (2002) (1)
exons in coincident sites in Statl and Stat2 (1)
STAT-4 N-DOMAIN (1998) (1)
Eukaryotic RNAs : Once More from the Beginning (1999) (1)
Biochemical events in mRNA formation in mammalian cells. (1976) (1)
Liver-specific RNA metabolism in hepatocytes in long-term culture (1986) (1)
Transcriptional Control of β-Globin and Liver-Specific Genes in Mouse Cells (1984) (1)
VARIETY IN THE MECHANISMS OF ADENOVIRUS GENE CONTROL * (1980) (1)
181. The Effect of Dissolved Oxygen Fluctuations on Cell Growth and Plasmid Yield (2005) (0)
Table of Contents (1996) (0)
Conferences and courses (2000) (0)
Obituary: Hidesaburo Hanafusa (1929–2009) (2009) (0)
Facteur de transcription enrichi par extraits hepatiques (1991) (0)
Structural Genes of the Urinary Protein Are on Mouse Major Chromosome 4 (2002) (0)
Importin Transcription STAT P NRTK JAK NRTK Cytokines Growth factors Peptides or (0)
Thoughts about gene regulation and mammalian development. (1989) (0)
Stat 3 and Stat 4 : Members of the family of signal transducers and activators of transcription ( transcription factors ) (0)
Two contact regions between Statl and CBP/p300 in IFN-γ signaling (1997) (0)
TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX (1998) (0)
New Editors, Features and Procedures (1989) (0)
U.S.-Japan seminar on "oncogenes in relation to developmental and transcriptional control". (1987) (0)
Correction (2020) (0)
A precise termination site in the mouse beta major-globin transcription unit. (1983) (0)
STAT 3 activation by cytokines utilizing gp 130 and related transducers involves a secondary modification reqluiring an H 7-sensitive kinase ( ciliary neurotrophic factor / interleukin 6 / leukemia-inhibitory factor / oncostatin M / granulocyte colony-stimulating factor ) (2005) (0)
Spending to Save: Financial Reform for the Medicine of the Future (1994) (0)
Nucleic Acids Research because of high levels of expression from the plasmid in the absence of IFN (2005) (0)
318. Collaborative Development of an Effective Method To Produce Clinical RNAi Products (2006) (0)
花房秀三郎氏（1929–2009） (2009) (0)
Comparison of Sonic Vibration and Freeze-Thaw Procedures ~ or Rdease of Poliovirus from HeLa Cells Early and Late in the Infectious Cycle (2003) (0)
Transcription UnitMappinginAdenovirus: Regions ofTermination (1986) (0)
Gordon Tomkins (1975) (0)
RNA: Life’s Indispensable Molecule , by James E. Darnell. (2011) (0)
Nucleic Acids Research (2009) (0)
Gamma Interferon-Driven Transcription The Linker Domain of Stat 1 Is Required for (1999) (0)
, src Transformation by v-Stat 3 Activation Is Required for Cellular (1998) (0)
574. Early Stage Product Development to Scale-Up: Use of Mini-Fermentation System for Screening and Process Development of Plasmid DNA Products (2005) (0)
Structure of Unphosphorylated STAT1 (2005) (0)
Dispositifs et procedes de production de biomateriaux (2004) (0)
Interferon induction of gene transcription analyzed by in vivo footprinting (1992) (0)
Lasker celebrates cell biology (2002) (0)
Apparatus and methods for biomaterialeproduktion (2004) (0)

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