James Fraser Mustard

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James Fraser Mustard

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Why Is James Fraser Mustard Influential?

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According to Wikipedia, James Fraser Mustard was a Canadian doctor and renowned researcher in early childhood development. Born, raised and educated in Toronto, Ontario, Mustard began his career as a research fellow at the University of Toronto where he studied the effects of blood lipids, their relation to heart disease and how Aspirin could mitigate those effects. He published the first clinical trial showing that aspirin could prevent heart attacks and strokes. In 1966, he was one of the founding faculty members at McMaster University's newly established medical school. He was the Dean of the Faculty of Health Sciences and the medical school at McMaster University from 1972 to 1982. In 1982, he helped found the Canadian Institute for Advanced Research and served as its founding president, serving until 1996. He wrote several papers and studies on early childhood development, including a report used by the Ontario Government that helped create a province-wide full-day kindergarten program. He won many awards including being made a companion of the Order of Canada – the order's highest level – and was inducted into the Canadian Medical Hall of Fame. He died November 16, 2011.

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James Fraser Mustard's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Preparation of Suspensions of Washed Platelets from Humans (1972) (865)
Factors influencing platelet function: adhesion, release, and aggregation. (1970) (616)
Adenosine Diphosphate‐induced Platelet Aggregation in Suspensions of Washed Rabbit Platelets (1970) (405)
Factors responsible for ADP-induced release reaction of human platelets. (1975) (350)
The effect of plasma proteins on the interaction of platelets with glass surfaces. (1969) (304)
THE EFFECT OF ACETYLSALICYLIC ACID ON PLATELET FUNCTION (1968) (277)
Fibrinogen and ADP-induced platelet aggregation (1978) (247)
Mechanisms of platelet shape change, aggregation, and release induced by collagen, thrombin, or A23,187. (1977) (231)
Platelet interaction with damaged rabbit aorta. (1979) (224)
Aggregation of rabbit platelets by platelet-activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs. (1979) (221)
Adenosine diphosphate-induced platelet aggregation and myocardial infarction in swine. (1967) (216)
Effects on platelet function of removal of platelet sialic acid by neuraminidase. (1975) (210)
EFFECT OF ADENOSINE NUCLEOTIDES ON PLATELET AGGREGATION AND CLOTTING TIME. (1964) (193)
ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDS (1967) (181)
Localized protein accumulation in the wall of the aorta. (1967) (176)
Clinical pharmacology of platelets. (1977) (171)
Factors influencing thrombus formation in vivo. (1962) (169)
Platelet interaction with polymerizing fibrin. (1972) (165)
Adherence of platelets to a collagen-coated surface: development of a quantitative method. (1973) (164)
Resolution and organization of platelet-rich mural thrombi in carotid arteries of swine. (1967) (162)
PLATELET PHAGOCYTOSIS AND AGGREGATION (1965) (154)
Coagulation Tests and Platelet Economy in Atherosclerotic and Control Subjects (1962) (151)
The effect of platelet age on platelet adherence to collagen. (1968) (148)
Influence of Apyrase on Stability of Suspensions of Washed Rabbit Platelets (1971) (148)
THE EFFECT OF SULFINPYRAZONE (ANTURAN) ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN. (1965) (145)
Properties of Washed Human Platelets (1977) (144)
Effect of the Concentration of Ca2+ in the Suspending Medium on the Responses of Human and Rabbit Platelets to Aggregating Agents (1989) (143)
In Vitro and in Vivo Functions of Thrombin-Treated Platelets (1976) (141)
Isolation of human platelets from plasma by centrifugation and washing. (1989) (140)
Effect of Smoking on Blood Coagulation and Platelet Survival in Man* (1963) (136)
Deposition of formed elements of blood on the intima and signs of intimal injury in the aorta of rabbit, pig, and man. (1972) (132)
Response of platelets to tissue injury. (1968) (129)
Sodium arachidonate can induce platelet shape change and aggregation which are independent of the release reaction. (1976) (127)
Platelet Aggregation and Release of ADP, Serotonin and Histamine Associated with Phagocytosis of Antigen-Antibody Complexes.∗ (1965) (127)
Experience-based brain development: Scientific underpinnings of the importance of early child development in a global world. (2006) (119)
Adenosine diphosphate-induced platelet aggregation and vascular injury in swine and rabbits. (1970) (118)
Encrustation and atherosclerosis: the analogy between early in vivo lesions and deposits which occur in extracorporeal circulations. (1962) (118)
Survival of rabbit platelets treated in vitro with chymotrypsin, plasmin, trypsin, or neuraminidase. (1979) (116)
Thrombin generation and fibrin formation following injury to rabbit neointima. Studies of vessel wall reactivity and platelet survival. (1982) (109)
Thromboembolism: A Manifestation of the Response of Blood to Injury (1970) (107)
Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival (1973) (105)
Shortening of the bleeding time in rabbits by hydrocortisone caused by inhibition of prostacyclin generation by the vessel wall. (1979) (103)
Platelet Economy (Platelet Survival and Turnover) * (1966) (102)
PLATELETS AND ATHEROSCLEROSIS. (1964) (100)
Experimental hemostasis in normal dogs and dogs with congenital disorders of blood coagulation. (1967) (98)
Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates. (1990) (97)
Platelet aggregation and release: effects of low concentrations of thrombin or collagen. (1973) (96)
Release of Permeability Factors from the Blood Platelet∗ (1965) (95)
Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment. (1981) (94)
Comparison of Fibrinogen Association With Normal and Thrombasthenic Platelets on Exposure to ADP or Chymotrypsin (1979) (93)
The role of platelets in the development and complications of atherosclerosis. (1986) (92)
Release of 14C-serotonin during initial platelet changes induced by thrombin, collagen, or A23187. (1977) (91)
Synergism between platelet aggregating agents: the role of the arachidonate pathway. (1977) (90)
The effect of pretreatment of human or rabbit platelets with chymotrypsin on their responses to human fibrinogen and aggregating agents. (1979) (90)
Effect of Different Dietary Fats on Blood Coagulation, Platelet Economy, and Blood Lipids* (1962) (89)
STUDY OF PLATELET ADHESIVENESS AND AGGREGATION, WITH LATEX PARTICLES. (1965) (87)
Reduced Membrane Fluidity in Platelets From Diabetic Patients (1990) (85)
The Effect of Prostaglandin E1 on Platelet Function in Vitro and in Vivo (1970) (84)
Thromboxane A2 causes feedback amplification involving extensive thromboxane A2 formation on close contact of human platelets in media with a low concentration of ionized calcium (1987) (83)
The determinants of health from a historical perspective. (1994) (81)
Fibrinogen and ADP-induced platelet aggregation. (1978) (80)
Changes in 32P‐Content of Phosphatidic Acid and the Phosphoinositides of Rabbit Platelets during Aggregation Induced by Collagen or Thrombin (1974) (77)
Effect of inhibitors of the arachidonate pathway on the release of granule contents from rabbit platelets adherent to collagen. (1980) (77)
Acetylsalicylic acid : new uses for an old drug (1982) (76)
Changes in phosphatidylinositol-4,5-bisphosphate 10 seconds after stimulation of washed rabbit platelets with ADP (1982) (73)
BLOOD COAGULATION AND PLATELET ECONOMY IN SUBJECTS WITH PRIMARY GOUT. (1963) (73)
Density subpopulations of rabbit platelets: size, protein, and sialic acid content, and specific radioactivity changes following labeling with 35S-sulfate in vivo. (1981) (73)
Effect of adenine compounds on platelet aggregation. (1969) (73)
Clq inhibition of the interaction of collagen with human platelets. (1976) (72)
Platelets and Thrombosis in Acute Myocardial Infarction (1972) (72)
Vessel injury, platelet adherence, and platelet survival. (1983) (71)
Factors Influencing the Deaggregation of Human and Rabbit Platelets (1983) (71)
Effect of ADP‐induced Shape Change on Incorporation of 32P into Platelet Phosphatidic Acid and Mono‐, Di‐ and Triphosphatidyl Inositol (1973) (71)
Platelet adherence to fibrin and collagen. (1968) (69)
Thromboxane A2 causes feedback amplification involving extensive thromboxane A2 formation on close contact of human platelets in media with a low concentration of ionized calcium. (1987) (69)
Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin. (1979) (69)
The Role of Blood and Platelets in Atherosclerosis and the Complications of Atherosclerosis (1975) (69)
Changes in 32P‐Labelling of Platelet Phospholipids in Response to ADP (1972) (68)
Relationship between platelet aggregation and the thrombotic tendency in rats fed hyperlipemic diets. (1970) (67)
Interactions of polylysine with platelets. (1971) (66)
Effects of Penicillin G on Platelet Aggregation, Release, and Adherence to Collagen 1 (1973) (65)
Effects of the cell adhesion peptide, Arg-Gly-Asp-Ser, on responses of washed platelets from humans, rabbits, and rats. (1987) (65)
Platelets, blood flow, and the vessel wall. (1990) (63)
Platelets, thrombosis and atherosclerosis. (1977) (61)
Effects of Ethanol on Pathways of Platelet Aggregation In Vitro (1988) (61)
Quantitative radioisotopic measurement and scanning electron microscopic study of platelet adherence to a collagen-coated surface and to subendothelium with a rotating probe device. (1979) (60)
The effect of aspirin inhibition of PGI2 production on platelet adherence to normal and damaged rabbit aortae. (1980) (60)
EXPERIMENTAL ATHEROSCLEROSIS IN SWINE * (1965) (58)
Differences in inhibition of PGI2 production by aspirin in rabbit artery and vein segments. (1980) (57)
Effects of Plasmin on Rabbit Platelets (1985) (56)
The effect of sulfinpyrazone on platelet economy and thrombus formation in rabbits. (1967) (56)
Platelet factor-3 availability and the platelet release reaction. (1974) (55)
Platelet Function and Myocardial Infarction (1969) (54)
Fibrinogen-independent aggregation and deaggregation of human platelets: studies in two afibrinogenemic patients. (1987) (53)
Platelet-surface reaction and thrombosis. (1968) (53)
The role of PMN-leucocyte lysosomes in tissue injury, inflammation and hypersensitivity. VI. The participation of the PMN-leucocyte and the blood platelet in systemic aggregate anaphylaxis. (1968) (52)
Reversibility of the association of fibrinogen with rabbit platelets exposed to ADP. (1980) (52)
The occurrence of microthrombi on the aortic endothelium of swine. (1962) (52)
Inhibition of platelet adherence to damaged surface of rabbit aorta. (1975) (51)
Conditions Affecting the Responses of Human Platelets to Epinephrine (1988) (50)
Normal and abnormal haemostasis. (1977) (49)
Effect of viruses on platelet aggregation and platelet survival in rabbits. (1978) (48)
Platelet-surface interactions: relationship to thrombosis and hemostasis. (1967) (47)
Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: a historical perspective. (2005) (46)
Inositol phospholipid metabolism in human platelets stimulated by ADP. (1990) (46)
Cigarette smoking and platelet aggregation. (1966) (45)
Sequence of cellular responses in rabbit aortas following one and two injuries with a balloon catheter. (1988) (44)
Platelets, Drugs and Thrombosis (1975) (43)
Adhesion of Fibroblasts to Polymerizing Fibrin and Retraction of Fibrin Induced by Fibroblasts 1 (1972) (43)
Aspirin in the treatment of cardiovascular disease: a review. (1983) (43)
The Effect of the Phospholipase Inhibitor Mepacrine on Platelet Aggregation, the Platelet Release Reaction and Fibrinogen Binding to the Platelet Surface (1981) (42)
Effect of ionophore A23, 187 on thrombin-degranulated washed rabbit platelets. (1975) (42)
Inhibition of platelet adherence to a collagen-coated surface by nonsteroidal anti-inflammatory drugs, pyrimido-pyrimidine and tricyclic compounds, and lidocaine. (1974) (42)
Development of Nonthrombogenicity of Injured Rabbit Aortas Despite Inhibition of Platelet Adherence (1986) (42)
Prostaglandins I2 and E1 reduce rabbit and human platelet adherence without inhibiting serotonin release from adherent platelets. (1979) (42)
SOME EFFECTS OF ATROMID ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN. (1963) (42)
Survival of density subpopulations of rabbit platelets: use of 51Cr-or 111In-labeled platelets to measure survival of least dense and most dense platelets concurrently. (1983) (41)
The experimental production of atherosclerosis in swine following the feeding of butter and margarine. (1958) (41)
Blood platelet economy during moderate and intensive heparin therapy. (1963) (41)
Heparin and Thrombus Formation: Early Suppression and Late Enhancement * (1963) (41)
PLATELET INTERACTION WITH FIBRINOGEN AND FIBRIN: COMPARISON OF THE INTERACTION OF PLATELETS WITH THAT OF FIBROBLASTS, LEUKOCYTES, AND ERYTHROCYTES * (1972) (40)
The phosphoinositides exist in multiple metabolic pools in rabbit platelets. (1986) (40)
Inhibitors of ADP-induced platelet aggregation prevent fibrinogen binding to rabbit platelets and cause rapid deaggregation and dissociation of bound fibrinogen. (1981) (38)
Canine Factor‐VII Deficiency (1962) (38)
The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation. (1986) (38)
Separation of thrombin-treated platelets from normal platelets by density-gradient centrifugation. (1979) (38)
Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium. (1984) (38)
Modification of platelet adherence to protein-coated surfaces. (1973) (37)
Immunocytochemical localization of fibrinogen during thrombin-induced aggregation of washed human platelets. (1988) (37)
Rôle of platelets in thrombosis. (1966) (37)
Reactions of 14C-ADP and 14C-ATP with washed platelets from rabbits. (1971) (36)
Recent advances in molecular pathology: A review: Platelet aggregation, vascular injury and atherosclerosis (1967) (36)
Heparin inhibits thrombin binding to rabbit thoracic aorta endothelium. (1980) (35)
Tobacco and thrombosis. (1966) (35)
Inhibition and potentiation of platelet function by lysolecithin. (1977) (35)
Phospholipid transfer between plasma and platelets in vitro. (1976) (35)
Canine Haemophilia B (Christinas Disease) (1960) (35)
DIET AND THROMBUS FORMATION: QUANTITATIVE STUDIES USING AN EXTRACORPOREAL CIRCULATION IN PIGS. (1963) (34)
Prostaglandins and platelets. (1980) (34)
Comparison of the effect of egg yolk or butter on the development of atherosclerosis in swine. (1960) (34)
Early Brain Development and Human Development (2010) (34)
Injury Of Cultured Endothelial Cells By Thrombin-Stimulated Platelets (1986) (34)
Thrombin-induced inositol trisphosphate production by rabbit platelets is inhibited by ethanol. (1988) (33)
Adrenaline and Experimental Thrombosis * (1966) (33)
Pathways responsible for platelet hypersensitivity in rats with diabetes. I. Streptozocin-induced diabetes. (1986) (32)
Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin. (1984) (32)
Early Child Development and Experience-based Brain Development - The Scientific Underpinnings of the Importance of Early Child Development in a Globalized World * J. F. Mustard Founding President of The Canadian Institute for Advanced Research (2006) (32)
Extracorporeal Circulation: A Device for the Quantitative Study of Thrombus Formation in Flowing Blood (1963) (32)
Effects of Cephalothin and Penicillin G on Platelet Function in Vitro (1977) (31)
Platelets and thrombosis in the development of atherosclerosis and its complications. (1978) (31)
Pharmacology of platelet-affecting drugs. (1980) (31)
Renal lesions and rise in blood pressure caused by adenosine diphosphate-induced platelet aggregation in rabbits. (1970) (31)
Effect of ADP‐Induced Aggregation on 32PO4 Incorporation into Phosphatidic Acid and the Phosphoinoistides of Rabbit Platelets (1973) (31)
Pathways responsible for platelet hypersensitivity in rats with diabetes. II. Spontaneous diabetes in BB Wistar rats. (1986) (30)
Uncontrolled PGI2 production by whole vessel wall segments due to thrombin generation in vivo and its prevention by heparin. (1979) (30)
The effect of adenine nucleotides on thrombus formation, platelet count, and blood coagulation. (1966) (30)
Labeling of the releasable adenine nucleotides of washed human platelets. (1977) (30)
Dicumarol Therapy and Platelet Turnover (1961) (30)
The transformation of hemostatic platelet plugs in normal and Factor IX deficient dogs. (1968) (30)
Platelets and diabetes mellitus. (1977) (29)
Effect of external calcium and magnesium on thrombin-induced changes in calcium and magnesium of pig platelets. (1973) (29)
Effect of Newcastle disease virus on human or rabbit platelets. Aggregation and loss of constituents. (1973) (29)
Immunocytochemical localization of fibrinogen on washed human platelets. Lack of requirement for fibrinogen during adenosine diphosphate-induced responses and enhanced fibrinogen binding in a medium with low calcium levels. (1988) (29)
The Influence of Red Blood Cells on the Effects of Aspirin or Sulphinpyrazone on Platelet Adherence to Damaged Rabbit Aorta (1979) (29)
Ultrastructural changes in re-endothelialized and non-endothelialized rabbit aortic neo-intima following re-injury with a balloon catheter. (1984) (28)
In Vitro Effects of Ethanol on Rabbit Platelet Aggregation, Secretion of Granule Contents, and Cyclic AMP Levels in the Presence of Prostacyclin (1989) (28)
Effect of heparin on platelet economy in dogs. (1967) (28)
Effect of diet-induced hyperlipidemia on in vitro-function of rabbit platelets. (1976) (28)
Effect of dipyridamole and prostacyclin on rabbit platelet adherence in vitro and in vivo. (1982) (27)
Serotonin transport and storage in rabbit blood platelets--the effects of reserpine and imipramine. (1977) (27)
The effect of acetylsalicylic acid and indomethacin on rabbit platelet adherence to collagen and the subendothelium in the presence of a low or high hematocrit. (1978) (27)
The Effect of Pyrazole Compounds on Thrombin-Induced Platelet Aggregation∗ (1969) (27)
Blood coagulation in subjects with and without clinical evidence of atherosclerotic vessel disease. (1958) (27)
Platelet aggregation and the platelet release reaction in thromboembolism. (1970) (26)
Effect of pyrimido-pyrimidine compounds on platelet function. (1971) (26)
The use of the synthetic peptide, Gly-Pro-Arg-Pro, in the preparation of thrombin-degranulated rabbit platelets. (1982) (26)
The effect of glucose on adenosine diphosphate-induced platelet aggregation. (1970) (26)
Platelet Survival and Thrombosis (1982) (26)
The Activation of Factor VIII by Thrombin (1965) (26)
Platelet adherence to the vessel wall and to collagen-coated surfaces. (1978) (26)
Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets (1984) (26)
SWINE ATHEROSCLEROSIS: THE RELATIONSHIP OF LIPIDS AND BLOOD COAGULATION TO ITS DEVELOPMENT * (1963) (26)
Effects of Tris on Responses of Human and Rabbit Platelets to Aggregating Agents (1984) (26)
Mechanisms in thrombosis. (1984) (26)
Acute administration of ethanol to rabbits inhibits thrombus formation induced by indwelling aortic catheters. (1990) (26)
MODIFICATION OF PLATELET FUNCTION (1972) (25)
Dicumarol Therapy: Some Effects on Platelets and Their Relationship to Clotting Tests (1960) (25)
Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets. (1987) (25)
Platelet phagocytosis. (1965) (25)
Reactions of Polylysine with Human Platelets in Plasma and in Suspensions of Washed Platelets (1976) (25)
The effect of dietary saturated fat and cholesterol on platelet function, platelet survival and response to continuous aortic injury in rats. (1987) (24)
Transport and storage of serotonin by thrombin-treated platelets (1975) (24)
Platelets in Stored Blood (1956) (24)
Effect of ticlopidine on platelet aggregation, adherence to damaged vessels, thrombus formation and platelet survival. (1985) (23)
Platelet sialic acid and platelet survival after aggregation by ADP (1980) (23)
Effect of streptokinase on hemostasis. (1968) (23)
Some in vitro effects of various concentrations of disodium ethylenediamine tetracetate, potassium oxalate, and sodium citrate on coagulation of blood. (1958) (23)
Survival of Washed Rabbit Platelets in Vivo 1 (1973) (22)
Investigation of possible mechanisms of pyridoxal 5'-phosphate inhibition of platelet reactions. (1980) (22)
AMP inhibition of reactions of ADP with washed platelets from humans and rabbits. (1972) (22)
Effect of Aspirin and Sodium Salicylate on Thrombosis, Fibrinolysis, Prothrombin Time, and Platelet Survival in Rabbits With Indwelling Aortic Catheters (1983) (22)
Platelet survival in rats with spontaneous diabetes mellitus. (1987) (22)
Quantitative studies on the effect of dicumarol on experimental thrombosis. (1963) (22)
Comparison of methods of measuring loss of cytoplasmic constituents from platelets. (1976) (21)
The effect of aggregating agents on oxidative metabolism of rabbit platelets. (1971) (21)
THE ROLE OF THROMBOGENIC FACTORS IN ATHEROSCLEROSIS (1968) (20)
Inhibition of platelet adherence to a collagen-coated surface by agents that inhibit platelet shape change and clot retraction. (1974) (20)
Effect of clofibrate on platelet economy in man. (1967) (20)
Characteristics of Thrombin-Degranulated Human Platelets: Development of a Method that Does not Use Proteolytic Enzymes for Deaggregation (1991) (20)
ADP-induced changes in [32P]phosphate labeling of phosphatidylinositol-4,5-bisphosphate in washed rabbit platelets made refractory by prior ADP stimulation. (1983) (20)
Effect of cAMP Phosphodiesterase Inhibitors on ADP-Induced Shape Change, cAMP and Nucleoside Diphosphokinase Activity of Rabbit Platelets (1982) (20)
Conditions influencing platelet lysis. (1975) (20)
The effect of glucose on the platelet response to release-inducing stimuli. (1972) (19)
A Study of Changes in Platelets, Antihaemophilic Globulin, Factor V and Factor VII During Blood Collection and Storage by Different Techniques (1957) (19)
An overview of antiplatelet and antithrombotic drugs. (1985) (19)
Dynamics of thrombus formation. (1977) (19)
Effect of Amino Sugars on Platelet Aggregation and on Fibrinogen Binding (1984) (19)
Shortening of the bleeding time in thrombocytopenic rabbits after exposure of jugular vein to high aspirin concentration. (1979) (19)
Energy Metabolism in Washed Human Platelets Responsive to ADP: Comparison with Platelets in Plasma (1973) (18)
Platelet antiplasmin: its extrusion during the release reaction, subcellular localization, characterization, and relationship to antiheparin in pig platelets. (1976) (18)
Deaggregation of Human Platelets Aggregated by Thrombin (1985) (18)
Effects of Intravenous Phospholipid Containing Phosphatidyl Serine on Blood Clotting with Particular Reference to the Russell's Viper Venom Time (1962) (17)
Platelets and thrombosis. (1966) (17)
The pattern of platelet disappearance. (1967) (17)
Lack of Stability of Aggregates after Thrombin-Induced Reaggregation of Thrombin-Degranulated Platelets (1992) (17)
Effects of sodium periodate on platelet functions. (1976) (17)
Interactions of nucleoside di- and triphosphates with rabbit platelets. (1974) (17)
Reversal of shortened platelet survival in rats by the antifibrinolytic agent, epsilon aminocaproic acid. (1983) (17)
Measurement of Fibrinogen Concentrations in Suspensions of Washed Rabbit and Human Platelets by Radioimmunoassays (1985) (17)
Effects of ethanol on rabbit platelet responses to collagen in vitro and ex vivo and on platelet adhesion to de-endothelialized aortae in vivo. (1987) (17)
Loss of sulfated proteoglycan from the surface of rabbit platelets during adenosine 5'-diphosphate-induced aggregation. (1976) (16)
Platelet interactions with the endothelium and the subendothelium: the role of thrombin and prostacyclin. (1979) (16)
Thrombosis and Atherosclerosis (1974) (16)
Platelet economy during moderate and intensive Dicoumarol therapy. (1961) (16)
The inhibitory effects of exogenous arachidonic acid on rabbit platelet aggregation and the release reaction. (1982) (16)
Inhibition of platelet adhesion to rabbit aorta by sulphinpyrazone and acetylsalicylic acid. (1977) (16)
Factor VII survival and turnover in dogs. (1967) (16)
The effects of sitosterol on serum cholesterol, platelet economy, thrombogenesis and atherosclerosis in the rabbit. (1973) (16)
Experimental modification of platelet survival. (1977) (16)
Transfer of adenine nucleotides between the releasable and nonreleasable compartments of rabbit blood platelets (1975) (16)
Factors Influencing the Deaggregation of Chymotrypsin-Treated Human Platelets Aggregated by Fibrinogen (1983) (16)
Adenine nucleotides in thrombin-degranulated platelets: effect of prolonged circulation in vivo. (1977) (16)
Drugs inhibiting platelet function (1973) (15)
Divalent cations and the release reaction of pig platelets. (1974) (15)
Platelets, endothelium, and vessel injury. (1985) (15)
Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets. (1984) (15)
Platelet activation--an overview. (1987) (15)
The role of platelet aggregation in the development of endotoxin shock. (1969) (15)
Comparison of the Interactions of Fibrinogen and Soluble Fibrin with Washed Rabbit Platelets Stimulated with ADP (1985) (14)
Eicosapentaenoic Acid Interferes with U46619-Stimulated Formation of Inositol Phosphates in Washed Rabbit Platelets (1989) (14)
Distribution of cellular responses in rabbit aortae following one and two injuries with a balloon catheter. (1988) (14)
The effect of stored blood transfusions on the platelet levels in patients undergoing surgical procedures. (1957) (14)
Drug effects on platelet adherence to collagen and damaged vessel walls. (1978) (14)
Effect of heparin and thrombin on platelet adherence to the surface of rabbit aorta. (1978) (13)
Changes in phosphatidylinositol-4,5-bisphosphate 10 seconds after stimulation of washed rabbit platelets with ADP. (1982) (13)
The effect of a platelet-derived growth factor on the proliferation of rabbit arterial smooth muscle cells in tissue culture. (1979) (13)
Platelet adhesion. (1984) (13)
Enzyme activities on the platelet surface in relation to the action of adenosine diphosphate. (1975) (13)
Early Human Development – Equity from the Start – Latin America (2009) (13)
Aggregation-related association of lipid with the cytoskeleton of rabbit and human platelets prelabeled with [3H]palmitic acid. Similar effects of adenosine diphosphate- and thrombin-induced aggregation. (1988) (13)
Adherence of Latex Particles to Platelets (1966) (13)
The Gordon Wilson lecture: function of blood platelets and their role in thrombosis. (1976) (13)
A disorder resembling hemophilia B (Christmas disease) in dogs. (1960) (12)
Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets. (1987) (12)
The Effect of Adrenaline Infusions on Blood Coagulation in Normal and Haemophilia B Dogs (1966) (12)
The Estimation of Blood Platelet Survival (1972) (12)
Effect of a Natural Phosphatidyl Serine Fraction on Blood Coagulation, Platelet Aggregation and Haemostasis (1969) (11)
The Influence of Blood Collecting Techniques on Platelet Numbers during Blood Storage (1957) (11)
Conditions Influencing the Interaction of Asialo von Willebrand Factor with Human Platelets – The Effects of External Ionized Calcium Concentration and the Role of Arachidonate Pathway (1988) (11)
Platelet reactions. (1971) (11)
Focal aortic injury caused by cannulation: increased plasma protein accumulation and thrombosis. (2009) (11)
Platelet aggregation: relevance to thrombotic tendencies. (1978) (11)
Phosphatidylinositol 4,5-bisphosphate is selectively retained by platelet-fibrin clots formed by thrombin. (1987) (11)
Thrombogenic and Nonthromboge0nic Biological Surfaces (1987) (11)
Endogenous mediators of platelet activation (1987) (11)
The Effect of Thrombin on Platelet Accumulation on the Vessel Wall - Influence of Heparin and Aspirin (1983) (10)
Changes in the properties of platelets from rats with experimentally induced shortened platelet survival. (1983) (10)
Effects of methyl prednisolone on platelet adhesion to damaged aorta bleeding time and platelet survival (1976) (10)
Atherosclerosis. Current Concept. (1981) (10)
The structure of thrombus-like deposits formed in extracorporeal shunts. (1970) (10)
Investigation of In Vivo Factors that May Influence Platelet Survival and Density (1979) (10)
The National Forum on Family Security: Social Economic Factors and Human Development. (1993) (10)
Platelet economy and blood coagulation in gout (1962) (9)
Platelets, thrombosis and atherosclerosis. (1978) (9)
Platelets, Thrombosis and Drugs (2012) (9)
Effects on the buoyant density of rabbit platelets of ADP and agents that increase the concentration of cyclic AMP. (1985) (9)
Myocardial infarction in an old dog. (1968) (9)
Effect of the amount and type of dietary fat on platelet function, platelet survival and response to continuous aortic injury in rats. (1987) (8)
Changes in the platelet levels of non-transfused patients following surgical operations. (1957) (8)
Increased activity of the coagulation mechanism during alimentary lipaemia: its significance with regard to thrombosis and atherosclerosis. (1957) (8)
The effect of prostaglandins E1, I2 and F2 alpha on the shape and phosphatidylinositol-4,5-bisphosphate metabolism of washed rabbit platelets. (1982) (8)
Incorporation of 32PO4 into Phospholipids of Blood Platelets (1977) (8)
Effect of aspirin and sodium salicylate on thrombosis, fibrinolysis, prothrombin time, and platelet survival In rabbits with indwelling aortic catheters. (1983) (8)
Blood coagulation during alimentary lipaemia in subjects with and without clinical evidence of atherosclerosis. (1958) (7)
Platelets in thromboembolic disease. (1970) (7)
Effects of Penicillin G and Cephalothin on Platelet Function in Vivo (1976) (7)
Epinephrine-Induced Aggregation of Rabbit Platelets Refractory to ADP (1985) (7)
The Fate of Di‐isopropylfluorophosphonate‐32P and Sulphur‐35S Labels on Platelets during Blood Coagulation * (1963) (7)
The Role of Heparin on the Inhibition of Platelet Adhesion to Damaged Arterial Endothelial Surface (1975) (7)
Platelet function and survival in rats with genetically determined hypercholesterolaemia. (1989) (7)
The role of platelets in the early and late stages of atherosclerosis and its clinical complications. (1988) (7)
Effect of activation of the fibrinolytic mechanism on experimental platelet-rich thrombi in rabbits. (1968) (7)
Effect of streptokinase therapy on experimental fibrin-rich arterial thrombi. (1971) (7)
Platelets in Thrombotic and Non-thrombotic Disorders: History of platelets (2002) (7)
Brain development, child development - Adult health and well-being and paediatrics. (1999) (7)
Non-Steroidal Anti-Inflammatory Drugs, Pyrimido-Pyrimidine Compounds and Tricyclic Compounds (1975) (6)
New trends in health sciences education, research, and services: The McMaster experience (1982) (6)
Effect of reserpine on adenosive uptake and metabolism, and subcellular transport of platelet adenosine triphosphate in washed rabbit platelets. (1977) (6)
Lack of Effect of UPD, UDPG, and Glucosamine on Platelet Reactions with Collagen (1974) (6)
Thrombin binding to platelets from hypercholesterolaemic rats. (1988) (6)
Effects of reserpine on rabbit platelet aggregation and adherence to collagen or injured rabbit aorta. (1977) (5)
Platelets in Thrombosis: Mechanisms and Therapy (1969) (5)
The effect of clofibrate on platelets. (1968) (5)
Platelet sialic acid and platelet survival after aggregation by ADP. (1980) (5)
Changes in Phosphoinositides in Rabbit Platelets during Clot Formation. Comparison of Platelets Stimulated by ADP or by Thrombin in the Presence of Polymerising Fibrin. (1990) (5)
Thrombosis and Endothelial Injury in Atherogenesis (1977) (5)
Platelets and blood coagulation in arterial and venous blood. (1963) (5)
RAUWOLFIA DERIVATIVES AND BREAST CANCER (1974) (5)
Effect of indomethacin, sulfinpyrazone and dipyridamole on the release of the platelet-derived growth factor. (1979) (5)
Platelet accumulation and turnover on de-endothelialized aortae in rats. (1989) (5)
The unrealized potenital of animal diseases in the study of human diseases. (1968) (5)
Inhibition by Ethanol of Thrombus Formation Induced by Indwelling Aortic Catheters in Rabbits (1991) (5)
A Comparison of the Effect of Serum and Plasma Transfusions on the Clotting Defect in Canine Haemophilia B (1962) (5)
LONG-TERM EFFECTS OF INTERMITTENT LOW DOSES OF HEPARIN ON PLATELET ECONOMY IN MAN. (1965) (4)
Coronary Heart Disease from a Population Perspective (2017) (4)
Canadian progress in early child development - putting science into action. (2009) (4)
The Effect of Synthetic Phosphatidyl Serines on Platelet Aggregation, Blood Coagulation and Haemostasis (1971) (4)
Platelets, thrombosis and vascular disease. (1961) (4)
Identical behavior of fibrinogen and asialo-fibrinogen in reactions with platelets during ADP-induced aggregation. (1980) (4)
Health professional education (1978) (4)
The assessment of platelet adherence. (1967) (4)
In vitro Methods and the Study of Platelet Mechanisms (1981) (4)
The relation among vessel injury, thrombus formation, and platelet survival in rabbits. (1984) (4)
The use and analysis of multiple responses in multicompartment cellular systems. (1975) (4)
Vessel Injury, Thrombosis, and the Progression and Regression of Atherosclerotic Lesions (1983) (4)
Plasma Fibronectin Is Not Involved in ADP-Induced Aggregation of Rabbit Platelets (1980) (4)
An investigation into the role of coagulation factor XIII in ADP-induced aggregation and fibrinogen binding with rabbit platelets. (1982) (4)
Platelets and diabetes mellitus. (1984) (4)
Localization of fibrinogen during ADP- or thrombin-induced aggregation of washed rabbit platelets. (1990) (4)
The Effect of Barbituric Acid Derivatives on Platelet Function in Vitro and in Vivo (1973) (4)
Association of fibrinogen with human platelets pretreated with chymotrypsin or aggregated with ADP or thrombin: an immunocytochemical study. (1989) (4)
Prolonged Inhibition of PGI2 Production and Associatedincreased Thrombogenic Effect in Arteries After Aspirin Administration (1979) (4)
Separation of Degranulated Platelets from Normal Platelets (1977) (4)
Putting Science into Action Putting Science into Action Putting Science into Action Putting Science into Action Putting Science into Action (2007) (3)
Hemostasis and thrombosis. (1968) (3)
Role of Platelets in Stroke and Transient Ischemic Attack (1981) (3)
Thrombin-induced inositol phosphate production by platelets from rats with diet-induced or genetically determined hypercholesterolemia. (1990) (3)
Thrombin-Induced Changes in Phosphatidic ACID (PA) and Phosphoinositides (1977) (3)
VITAMIN B6 AS AN ANTITHROMBOTIC AGENT (1981) (3)
4 – Pharmacology of Antiplatelet Agents and Their Role in Coronary Disease (1983) (3)
The relationship between the structure of a thrombus or a hemostatic plug and the mechanisms involved in its formation. (1968) (3)
[The serum defect in Christmas disease]. (1959) (3)
Platelet Aggregation, Phagocytosis, and Vessel Permeability (1966) (2)
Comparison Of The Effects Of Aspirin And Heparin On Platelet Accumulation On The Injured Neointima Of Rabbit Aortae (1981) (2)
Survival of rabbit platelets exposed to immune complexes. (1990) (2)
Hypersensitivity to thrombin of platelets from hypercholesterolemic rats (1986) (2)
Inhibition of platelet adherence to damaged vessel wall by drugs. (1977) (2)
Atherogenesis and its relation to stroke. (1982) (2)
PLATELET AGGREGATION INDUCED BY SWINE INFLUENZA VACCINE (1978) (2)
Medical education and research: the foundations of quality health care. (1966) (2)
Heparin lysolecithin, and platelet function. (1975) (2)
Hemostasis in domestic animals. (1966) (2)
Platelets: Pathophysiology and anti-platelet drug therapy (1983) (2)
BLOOD COAGULATION IN SOME COMMON LABORATORY ANIMALS. (1963) (2)
ANTICOAGULANTS IN ACUTE MYOCARDIAL INFARCTION (1961) (2)
Diet and Blood Coagulation (1962) (2)
Smoking and thrombosis. (1968) (2)
Platelet deposition in rabbit common carotid arteries promoted by arterial stenosis and spasm (2008) (2)
The role of platelets in thrombosis and atherosclerosis. (1967) (2)
Vessel injury, thrombosis and atherosclerosis (1984) (2)
Combinatorial problem arising in chaotic control (2002) (2)
Cigarette smoking, atherosclerosis and its clinical complications. (1981) (2)
Changes In Triphosphatidylinositol Metabolism During PGE1- Induced Shape Change Of Washed Rabbit Platelets (1981) (1)
PLATELET-FIBRIN CLOTS FORMED BY THROMBIN SELECTIVELY RETAIN PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIF2) (1987) (1)
Summing Up: Platelet Heterogeneity: Biology and Pathology (1990) (1)
Platelet Survival In Relation To Vessel Wall Injury (1981) (1)
Pathways of Thrombin-Induced Aggregation and Release with Human and Rabbit Platelets (1977) (1)
Vessel Injury, Thrombosis And Platelet Survival (1981) (1)
ANTICOAGULANT THERAPY FOR MYOCARDIAL INFARCTION (1962) (1)
Anesthetics and platelets. (1971) (1)
Platelet deposition in rabbit common carotid arteries promoted by arterial stenosisand spasm. A quantitative and morphological study. (2008) (1)
The Vessel Wall and Atherosclerosis (1980) (1)
Platelets, endothelium and vascular disease. (1963) (1)
Changes in the Activity of Clotting Factors in Relation to the Onset of Platelet Clumping and Fibrin Formation (1962) (1)
Platelets and atherosclerosis. (1965) (1)
Modifications of Platelets that Affect Platelet Adherence to Collagen or Damaged Aorta aud Platelet Survival (1975) (1)
Health care issues in the 1980s. (1980) (1)
platelets Willebrand factor to support the ADP-induced aggregation of human Effect of calcium ion concentration on the ability of fibrinogen and von (2011) (1)
Thrombogenic and nonthrombogenic biological surfaces. (1987) (1)
The activation of factor 8 by thrombin. (1965) (1)
THROMBOSIS AND VASCULAR DISEASE: A REVIEW OF RESEARCH NEEDS. (1963) (1)
Non-steroidal anti-inflammatory agents and coronary heart disease. (2009) (1)
IMMUNOCYTOCHEMICAL LOCALIZATION OF FIBRINOGEN DURING THROMBIN-INDUCED AGGREGATION OF HUMAN PLATELETS (1987) (1)
Inhibition of Collagen- or Thrombin-Induced Shape Change of Rabbit Platelets (1975) (1)
Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. (1993) (1)
Platelet-Derived Growth Factor Production During the Platelet Release Reaction Independent of The Endoperoxide Pathway. (1977) (1)
The Effects of Dietary Fats in Rabbits on Platelet Survival, Platelet Turnover, Platelet Density, PGI2 Production and Thrombus Formation in Response to an Aortic Indwelling Cannula (1979) (1)
Effect of drugs of platelets and complications of vascular disease. (1977) (1)
Effects of reserpine and serotonin on adenine nucleotide matabolism and glucose oxidation of washed rabbit platelets. (1977) (1)
Inhibitory Effect Of Exogenous Arachidonic Acid Or Linoleic Acid On Rabbit Platelet Aggregation And Release Reaction (1981) (1)
Acute Myocardial Infarction in the Presence of Thrombocytopenia. (1962) (1)
Summary of Workshop 1b: Smooth Muscle (1978) (1)
PGI2 Production and Effect of Aspirin on Endothelial Cells and Non-Endothelial Cells of the Vessel Wall (1979) (1)
Quantitation of Platelet Adherence to Rabbit Aortae and Platelet Survival After two Injuries with a Balloon Catheter (1979) (0)
[Future needs of clinical research in Canada]. (1962) (0)
Effects of Inhibitors of ADP-induced Aggregation on Platelet Nucleo-sidediphosphate Kinase (NDK) Activity (1975) (0)
ROLE OF RELEASED ADP IN THE STABILIZATION OF PLATELET AGGREGATES: STUDIES IN PATIENTS WITH DEFICIENCY IN AMINE STORAGE GRANULES CONTENTS (1987) (0)
Ontario's Mustard Report: Its Implications For Family Physicians. (1974) (0)
190 ARTERIOSCLEROSIS VOL 6 , No 2 , MARCH / APRIL 1986 Removal of Aortic Endothellum or Injury of Neolntlma with a Balloon Catheter (2005) (0)
Contents, Vol. 21, 1959 (1959) (0)
In vitro effects of ethanol on the pathways of platelet aggregation (1986) (0)
Creation of an elearning program-work in progress (2002) (0)
Anticoagulants and Ischemic Heart Disease. (1964) (0)
ETHANOL INHIBITS RABBIT PLATELET RESPONSES TO COLLAGEN IN VITRO BUT DOES NOT AFFECT RABBIT PLATELET ADHERENCE TO DE-ENDOTHELIALIZED A0RTAE IN VIVO (1987) (0)
Platelet Adhesion to Damaged Rabbit Aorta and the Effect of Acetylsalicylic Acid and Sulphinpyrazone (1976) (0)
DIET AND PLATELET FUNCTION (1976) (0)
The role of platelets in chronic rejection. (1970) (0)
How central funding and local planning can coexist in an effective health-care system. (1979) (0)
Symposium on Anticoagulants and Fibrinolysins. (1961) (0)
In vitro and in vivo effect of different fat preparations on blood coagulation. (1958) (0)
Register rerum ad Vol. 21 (1959) (0)
Atherosclerosis in swine fed normal rations and lipid enriched diets. (1965) (0)
Thrombosis - manifestation of the response of blood to injury. (1973) (0)
PATHOPHYSIOLOGY, BIOCHEMISTRY, AND PHARMACOLOGY OF PLATELETS (1985) (0)
Activity of the clotting mechanism during the extracorporeal shunting of blood. (1962) (0)
Prosperity or decline: Canada's choice (1996) (0)
An experimental approach to the problem of atherosclerosis. (1959) (0)
Closing remarks / conclusion. (1970) (0)
Health Research and Graduate Education (1972) (0)
Mechanisms in de aggregation of human platelets (1984) (0)
Evaluation of drug therapy in chronic diseases. (1967) (0)
Commentary. Drugs inhibiting platelet function. (1973) (0)
Register autorum ad Vol. 21 (1959) (0)
Fibrinogen and A D Pinduced Platelet Aggregation (2017) (0)
The Mechanisms of Action of Drugs that Modify Platelet and Vessel Wall Function (1980) (0)
Achieving Health for All: implications for Canadian health and social policies. (1987) (0)
Investigation Of The Origin Of The Density Heterogeneity Of Rabbit Platelets (1981) (0)
Concentrations Of cAMP Phosphodiesterase Inhibitors That Block The ADP-Induced Shape Change Of Rabbit Platelets Do Not Increase Platelet cAMP (1981) (0)
Effects of epinephrine on ADP-induced changes in platelet inositol phosphates (1986) (0)
Letter: Rauwolfia derivatives and breast cancer. (1974) (0)
ENHANCED THROMBIN-INDUCED AGGREGATION AND INOSITOL TRISPHOSPHATE FORMATION OF PLATELETS FROM SPONTANEOUSLY HYPERCHOLESTEROLEMIC RATS (1987) (0)
Health and health care in a post-industrial society. (1983) (0)
Future requirements of clinical research in Canada. (1962) (0)
Letter: Rauwolfia derivatives and breast cancer. (1974) (0)

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