James L. Manley

James L. Manley's AcademicInfluence.com Rankings

James L. Manley

Physics

#2798

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#4069

Historical Rank

physics Degrees

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Physics

James L. Manley's Degrees

PhD Physics University of California, Berkeley
Masters Physics Stanford University

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James L. Manley's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches (2009) (1140)
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer (2010) (963)
DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. (1980) (839)
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains (2000) (808)
Mechanism and regulation of mRNA polyadenylation. (1997) (769)
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010) (764)
SR proteins and splicing control. (1996) (722)
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability (2005) (694)
Alternative polyadenylation of mRNA precursors (2016) (669)
Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors (1994) (651)
RNA polymerase II and the integration of nuclear events. (2000) (606)
Mechanisms and consequences of alternative polyadenylation. (2011) (605)
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. (1996) (581)
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007) (578)
The RNA polymerase II CTD coordinates transcription and RNA processing. (2012) (559)
A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy (2003) (536)
Molecular architecture of the human pre-mRNA 3' processing complex. (2009) (494)
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro (1990) (459)
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila (1989) (455)
Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. (1997) (434)
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease (2006) (429)
The Polyadenylation Factor CstF-64 Regulates Alternative Processing of IgM Heavy Chain Pre-mRNA during B Cell Differentiation (1996) (406)
RNA polymerase II is an essential mRNA polyadenylation factor (1998) (386)
Transcriptional repression of eukaryotic promoters (1989) (381)
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. (1995) (380)
The ends of the affair: Capping and polyadenylation (2000) (365)
R-loop-mediated genomic instability is caused by impairment of replication fork progression. (2011) (356)
Transcription termination by nuclear RNA polymerases. (2009) (334)
Symplekin and xGLD-2 Are Required for CPEB-Mediated Cytoplasmic Polyadenylation (2004) (331)
ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle (2005) (328)
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II. (1988) (327)
High mobility group protein-1 (HMG-1) is a unique activator of p53. (1998) (319)
Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA (1997) (315)
Primary structure of the human splicing factor asf reveals similarities with drosophila regulators (1991) (308)
Synergistic activation and repression of transcription by Drosophila homeobox proteins (1989) (305)
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (2010) (283)
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. (1995) (282)
Functional domains of the Drosophila Engrailed protein. (1993) (282)
Cell signalling and the control of pre-mRNA splicing (2004) (281)
Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing. (1989) (280)
Alternative cleavage and polyadenylation: the long and short of it. (2013) (278)
Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. (1999) (262)
Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component (2000) (260)
Determinants of SR protein specificity. (1999) (256)
Misregulation of pre-mRNA alternative splicing in cancer. (2013) (254)
The TET family of proteins: functions and roles in disease. (2009) (252)
Splicing-related catalysis by protein-free snRNAs (2001) (244)
Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. (1993) (238)
The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing (1999) (237)
In vitro transcription: whole-cell extract. (1983) (235)
Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. (1996) (234)
Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase* (2002) (234)
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. (2000) (234)
Human Tra2 Proteins Are Sequence-Specific Activators of Pre-mRNA Splicing (1998) (230)
Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. (1998) (227)
The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression (2001) (227)
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. (1997) (225)
A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs. (1990) (223)
Why Is p53 Acetylated? (2001) (220)
The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site (2015) (217)
Phosphorylation–dephosphorylation differentially affects activities of splicing factor ASF/SF2 (1998) (217)
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock (2004) (217)
RNA recognition by the human polyadenylation factor CstF (1997) (214)
The SR Protein SRp38 Represses Splicing in M Phase Cells (2002) (205)
Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. (1995) (203)
A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing. (1995) (199)
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains (2016) (198)
Base substitution in an intervening sequence of a beta+-thalassemic human globin gene. (1981) (195)
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. (2004) (193)
Functional domains of the human splicing factor ASF/SF2. (1993) (191)
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. (1999) (190)
Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (2010) (186)
Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation (2015) (186)
hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing. (2007) (186)
Structure and in vitro transcription of human globin genes. (1980) (182)
Four factors are required for 3'-end cleavage of pre-mRNAs. (1989) (180)
Structure and function of the 5’→3’ exoribonuclease Rat1 and its activating partner Rai1 (2009) (180)
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. (2009) (179)
Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. (1996) (178)
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities (2015) (178)
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing (2014) (176)
Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus. (1992) (173)
Sequence specificity of the human mRNA N6-adenosine methylase in vitro. (1990) (173)
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. (2007) (172)
Cell-cycle related regulation of poly(A) polymerase by phosphorylation (1996) (170)
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. (2002) (168)
The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. (1998) (167)
RNAP II CTD Phosphorylated on Threonine-4 Is Required for Histone mRNA 3′ End Processing (2011) (165)
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. (2011) (163)
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. (2005) (162)
Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation (1988) (158)
Pin1 modulates the structure and function of human RNA polymerase II. (2003) (157)
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex (2010) (155)
Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. (2005) (155)
Cotranscriptional processes and their influence on genome stability. (2006) (154)
RNA-binding proteins in neurodegeneration: mechanisms in aggregate (2017) (150)
Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA (1991) (150)
Primary structure and expression of bovine poly(A) polymerase (1991) (148)
Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (2001) (147)
Polyadenylation of mRNA precursors. (1988) (145)
A polyadenylation factor subunit is the human homologue of theDrosophila suppressor of forked protein (1994) (144)
Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. (1992) (143)
TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters. (1992) (138)
DNA sequence required for initiation of transcription in vitro from the major late promoter of adenovirus 2. (1981) (137)
Strange bedfellows: polyadenylation factors at the promoter. (2003) (137)
Identification and Functional Characterization of Neo-Poly(A) Polymerase, an RNA Processing Enzyme Overexpressed in Human Tumors (2001) (135)
An intronic element contributes to splicing repression in spinal muscular atrophy (2007) (134)
Terminating the transcript: breaking up is hard to do. (2006) (132)
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo (1996) (132)
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors (2009) (129)
R Loops and Links to Human Disease. (2017) (128)
Regulation of Plant Developmental Processes by a Novel Splicing Factor (2007) (127)
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy (2010) (125)
Regulation of pre-mRNA splicing in metazoa. (1997) (123)
ASAP, a Novel Protein Complex Involved in RNA Processing and Apoptosis (2003) (123)
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. (1995) (121)
Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. (1998) (120)
The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. (1992) (116)
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells (2015) (114)
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements (2012) (113)
A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. (2007) (112)
PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins. (2006) (112)
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. (1994) (111)
Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non‐consensus sites (1998) (107)
Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells. (1991) (106)
Molecular basis for the recognition of the human AAUAAA polyadenylation signal (2017) (101)
Question of commitment (1993) (101)
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator (2008) (99)
Factors influencing alternative splice site utilization in vivo (1987) (99)
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins (2012) (98)
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription (2005) (97)
Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms (1996) (96)
Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1 (2010) (96)
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. (2007) (95)
SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3 (2015) (95)
The transcriptional repressor even-skipped interacts directly with TATA-binding protein (1995) (93)
SUMO functions in constitutive transcription and during activation of inducible genes in yeast. (2010) (92)
Pin1 modulates RNA polymerase II activity during the transcription cycle. (2007) (88)
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. (1993) (87)
The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. (1992) (84)
TLS Inhibits RNA Polymerase III Transcription (2009) (83)
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage (2013) (83)
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. (2009) (83)
An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression (2017) (82)
Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. (1992) (82)
Synthesis and degradation of termination and premature-termination fragments of β-galactosidase in vitro and in vivo (1978) (81)
Characterization of the catalytic activity of U2 and U6 snRNAs. (2003) (81)
Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation (2014) (81)
Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing (1985) (81)
A complex protein assembly catalyzes polyadenylation of mRNA precursors. (1995) (80)
A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates (1990) (79)
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein. (1996) (77)
The role of the polypyrimidine stretch at the SV40 early pre‐mRNA 3′ splice site in alternative splicing. (1988) (75)
Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation (2001) (74)
XRN2 Links Transcription Termination to DNA Damage and Replication Stress (2016) (74)
A human polyadenylation factor is a G protein beta-subunit homologue. (1992) (74)
RNA sequence containing hexanucleotide AAUAAA directs efficient mRNA polyadenylation in vitro (1985) (73)
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. (2003) (73)
Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting Pre-mRNA 3′ Cleavage (2002) (73)
RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor. (1979) (70)
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. (2009) (70)
Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery (2014) (70)
Transcriptional activators enhance polyadenylation of mRNA precursors (2011) (70)
RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3′ UTRs (2014) (70)
Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs (1984) (69)
Interaction between a transcriptional activator and transcription factor IIB in vivo (1993) (68)
PARP1 represses PAP and inhibits polyadenylation during heat shock. (2013) (67)
Poly(A) polymerase contains multiple functional domains (1994) (67)
The prolyl isomerase Pin1 functions in mitotic chromosome condensation. (2007) (66)
Accurate and specific polyadenylation of mRNA precursors in a soluble whole-cell lysate (1983) (65)
Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites (1987) (64)
Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty (2003) (63)
Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression. (1982) (63)
The search for alternative splicing regulators: new approaches offer a path to a splicing code. (2008) (63)
The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different posttranscriptional levels. (2000) (63)
Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1. (2019) (61)
A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates. (1991) (61)
Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation (1989) (61)
RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence (1989) (61)
In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites. (1984) (61)
Even-skipped Represses Transcription by Binding TATA Binding Protein and Blocking the TFIID-TATA Box Interaction (1998) (61)
The C-Terminal Domain of RNA Polymerase II Functions as a Phosphorylation-Dependent Splicing Activator in a Heterologous Protein (2005) (60)
Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube. (1998) (60)
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism (2018) (59)
A human homologue of the Escherichia coli DnaJ heat-shock protein. (1991) (59)
Cooperation between core promoter elements influences transcriptional activity in vivo. (1995) (58)
Sumoylation Modulates the Assembly and Activity of the Pre-mRNA 3′ Processing Complex (2007) (58)
Alternative splicing of SV40 early pre-mRNA is determined by branch site selection. (1988) (58)
Deregulation of Poly(A) Polymerase Interferes with Cell Growth (1998) (58)
Transcription of Simian virus 40 DNA in a HeLa whole cell extract. (1981) (58)
Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function. (2008) (56)
A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal (1989) (56)
SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors (2016) (56)
Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing. (2007) (54)
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. (2007) (54)
Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast. (2012) (53)
Transcriptional activators enhance polyadenylation of mRNA precursors. (2011) (53)
The 3′ processing factor CstF functions in the DNA repair response (2008) (53)
Control of adenovirus late promoter expression in two human cell lines (1985) (52)
TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency (2018) (52)
Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu (1992) (50)
RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance (2018) (50)
Nuclear coupling: RNA processing reaches back to transcription (2002) (50)
Function and Control of RNA Polymerase II C-Terminal Domain Phosphorylation in Vertebrate Transcription and RNA Processing (2014) (50)
Splicing of mRNA precursors: the role of RNAs and proteins in catalysis. (2009) (50)
RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells (2014) (48)
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity (2012) (47)
The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation. (2005) (47)
Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA (1988) (47)
RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo. (1979) (47)
Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity (2001) (46)
Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly (1989) (46)
Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock. (2005) (46)
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. (2011) (46)
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. (2012) (45)
A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. (2000) (45)
Creatine Phosphate, Not ATP, Is Required for 3′ End Cleavage of Mammalian Pre-mRNA in Vitro * (1997) (45)
In vitro transcription of adenovirus (1981) (44)
Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro (1987) (44)
Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells (1985) (44)
The End of the Message--Another Link Between Yeast and Mammals (1996) (44)
Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal. (1996) (44)
Robust mRNA Transcription in Chicken DT40 Cells Depleted of TAFII31 Suggests Both Functional Degeneracy and Evolutionary Divergence (2000) (44)
Rna synthesis in isolated nuclei processing of adenovirus serotype 2 late messenger rna precursors. (1982) (44)
RNA 3' ends: formation and function--meeting review. (1994) (43)
Heterozygous Disruption of the TATA-Binding Protein Gene in DT40 Cells Causes Reduced cdc25B Phosphatase Expression and Delayed Mitosis (2001) (43)
Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter. (1984) (42)
Mdm2 and MdmX as Regulators of Gene Expression. (2012) (41)
Sub1 Functions in Osmoregulation and in Transcription by both RNA Polymerases II and III (2009) (41)
A direct interaction between a glutamine-rich activator and the N terminus of TFIIB can mediate transcriptional activation in vivo (1995) (40)
Multiple Properties of the Splicing Repressor SRp38 Distinguish It from Typical SR Proteins (2005) (40)
Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response (2013) (39)
Structure and function of the S1 nuclease-sensitive site in the adenovirus late promoter (1986) (39)
Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair (2014) (38)
The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene. (2000) (38)
From transcription to mRNA: PAF provides a new path. (2005) (37)
Concurrent splicing and transcription are not sufficient to enhance splicing efficiency. (2007) (36)
Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression (2013) (36)
A novel protein factor is required for use of distal alternative 5' splice sites in vitro (1991) (36)
Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila. (2002) (35)
CPSF 30 and Wdr 33 directly bind to AAUAAA in mammalian mRNA 3 9 processing (2014) (35)
Synthesis in vitro of an exceptionally long RNA transcript promoted by an AluI sequence (1982) (35)
Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine. (1982) (34)
ALS mutations in TLS/FUS disrupt target gene expression (2015) (34)
The homeo box and mammalian development (1985) (34)
Analysis of the expression of genes encoding animal mRNA by in vitro techniques. (1983) (34)
Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling (2014) (34)
Poly(A) Polymerase Phosphorylation Is Dependent on Novel Interactions with Cyclins (2000) (34)
Core Promoter Elements and TAFs Contribute to the Diversity of Transcriptional Activation in Vertebrates (2003) (33)
The Drosophila even-skipped promoter is transcribed in a stage-specific manner in vitro and contains multiple, overlapping factor-binding sites (1990) (32)
In vitro splicing of simian virus 40 early pre mRNA. (1986) (32)
Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe (2017) (32)
Messenger RNA polyadenylylation: a universal modification. (1995) (30)
Functions of SR and Tra2 proteins in pre-mRNA splicing regulation. (1999) (30)
Human capping enzyme promotes formation of transcriptional R loops in vitro (2007) (28)
Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1 (2012) (28)
New Talents for an Old Acquaintance: the SR Protein Splicing Factor ASF/SF2 Functions in the Maintenance of Genome Stability (2005) (27)
Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism. (1995) (27)
Sumoylation controls the timing of Tup1-mediated transcriptional deactivation (2015) (26)
MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress (2012) (26)
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs (2020) (25)
DNA-protein complexes spread on N2-discharged carbon film and characterized by molecular weight and its projected distribution. (1982) (25)
Sub1 Globally Regulates RNA Polymerase II C-Terminal Domain Phosphorylation (2010) (25)
A functional simian virus 40 origin of replication is required for the generation of a super T antigen with a molecular weight of 100,000 in transformed mouse cells (1983) (24)
Pinning Down Transcription: Regulation of RNA Polymerase II Activity During the Cell Cycle (2004) (24)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (24)
The RNA polymerase C-terminal domain (2011) (24)
In Vivo Functional Analysis of the Histone 3-like TAF9 and a TAF9-related Factor, TAF9L* (2003) (24)
Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation (2020) (24)
SELEX to identify protein-binding sites on RNA. (2013) (23)
MPK1/SLT2 Links Multiple Stress Responses with Gene Expression in Budding Yeast by Phosphorylating Tyr1 of the RNAP II CTD. (2017) (23)
The RNA polymerase II CTD “orphan” residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7 (2018) (23)
The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling (2018) (23)
Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing (1992) (23)
Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (1995) (22)
Transcription of methylated eukaryotic viral genes in a soluble in vitro system. (1984) (22)
Allosteric regulation of even-skipped repression activity by phosphorylation. (1999) (22)
Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains (2020) (21)
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation (2020) (21)
Roles of Sumoylation in mRNA Processing and Metabolism. (2017) (21)
Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. (2010) (21)
Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites. (1990) (20)
Polyadenylylation of an mRNA precursor occurs independently of transcription by RNA polymerase II in vivo. (1986) (19)
Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation (2020) (19)
Heat Shock-Induced SRSF10 Dephosphorylation Displays Thermotolerance Mediated by Hsp27 (2010) (19)
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes (2020) (19)
C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms (2019) (18)
Intrinsic metal binding by a spliceosomal RNA (2002) (18)
Mutant p 53 cooperates with the SWI / SNF chromatin remodeling complex to regulate VEGFR 2 in breast cancer cells (2015) (18)
Cell- and promoter-specific activation of transcription by DNA replication. (1987) (18)
Localization of active promoters for eucaryotic RNA polymerase II in the long terminal repeat of avian sarcoma virus DNA (1983) (18)
A frameshift mutation affecting the carboxyl terminus of the simian virus 40 large tumor antigen results in a replication- and transformation-defective virus. (1983) (17)
Mechanisms of transcriptional activation and repression can both involve TFIID. (1996) (17)
New Links between mRNA Polyadenylation and Diverse Nuclear Pathways (2014) (16)
Selective translation initiation on bicistronic simian virus 40 late mRNA (1987) (16)
Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs. (1989) (16)
Suppression of amber mutants in vitro induced by low temperature. (1978) (16)
The human U6 snRNA intramolecular helix: structural constraints and lack of sequence specificity. (1997) (15)
New Insights into Mitotic Chromosome Condensation: A Role for the Prolyl Isomerase Pin1 (2007) (15)
NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells (2018) (15)
Synthesis and degradation of termination and premature-termination fragments of beta-galactosidase in vitro and in vivo. (1978) (14)
RNA 3'-end formation. (1989) (13)
Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. (2003) (13)
Intrinsic metal binding by a spliceosomal RNA (2002) (12)
The splicing regulator Sam 68 binds to a novel exonic splicing silencer and functions in SMN 2 alternative splicing in spinal muscular atrophy (2010) (12)
REGULATION OF ADENOVIRUS mRNA SYNTHESIS * (1980) (12)
Synthesis of internal re-initiation fragments of beta-galactosidase in vitro and in vivo. (1978) (12)
Tumor metabolism: hnRNP proteins get in on the act (2010) (12)
TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1 (2019) (12)
Transcription of mammalian genes in vitro. (1981) (11)
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U 2 AF 65 – Prp 19 complex (2011) (11)
Alternative Splicing and Control of Apoptotic DNA Fragmentation (2006) (11)
TLS/FUS (2012) (10)
Factor interactions with the simian virus 40 early pre-mRNA influence branch site selection and alternative splicing (1989) (10)
Multiple activities of the human splicing factor ASF. (1992) (10)
How bidirectional becomes unidirectional (2013) (10)
Alternative polyadenylation blooms. (2010) (10)
A UV-crosslinkable interaction in human U6 snRNA. (1998) (9)
RNA polymerase II terminates transcription in vitro in the SV40 origin region. (1987) (9)
In vitro sumoylation of recombinant proteins and subsequent purification for use in enzymatic assays. (2009) (9)
The use of simple model systems to study spliceosomal catalysis. (2008) (9)
Mtr4/ZFC3H1 protects polysomes through nuclear RNA surveillance (2017) (8)
Variations in Intracellular Levels of TATA Binding Protein Can Affect Specific Genes by Different Mechanisms (2007) (7)
36 – In Vitro Transcription: Whole-Cell Extract (1989) (6)
SETX sumoylation (2014) (6)
Lives of the stars (1980) (5)
Cell-free synthesis of SU + 3 tyrosyl transfer RNA: characterization of the 4S product. (1973) (5)
Emerging Roles for SUMO in mRNA Processing and Metabolism (2009) (5)
Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding (2020) (5)
Effects of the adenovirus 2 late promoter on simian virus 40 transcription and replication (1986) (4)
Drosophila Pelle phosphorylates Dichaete protein and influences its subcellular distribution in developing oocytes. (2010) (4)
7 – Factors That Influence Alternative Splice Site Selection in Vitro (1987) (4)
Oxidative stress induces Ser 2 dephosphorylation of the RNA polymerase II CTD and premature transcription termination (2021) (3)
SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes. (1991) (3)
Author response: The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains (2016) (3)
Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS (2022) (3)
Regulation of Nuclear Transport and Activity of the Drosophila Morphogen Dorsal (1995) (3)
The Drosophila TATA binding protein contains a strong but masked activation domain. (2001) (3)
Transcriptional regulators of Drosophila embryogenesis. (1992) (3)
Multiple ways to a dead end: diverse mechanisms by which ALS mutant genes induce cell death (2021) (2)
cFLIP expression is altered in severe corticosteroid-resistant asthma (2014) (2)
mRNA Polyadenylation in Eukaryotes (2013) (2)
Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology (2021) (2)
Functions of SR and Tra2 Proteins in Pre-mRNA Splicing Regulation (1999) (2)
Inhibition of mammalian polyadenylation by ATP analogs (2007) (1)
INTERVENING SEQUENCE MUTATION IN A CLONED HUMAN β + -THALASSEMIC GLOBIN GENE (1981) (1)
The Mechanism and Control of Pre-mRNA Splicing (1989) (1)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (1)
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis (2022) (1)
The Art of the Country (1987) (1)
Erratum: RNA-binding proteins in neurodegeneration: mechanisms in aggregate. (2017) (1)
InVitro Polyadenylation of SV40 Early Pre-mRNA (1987) (1)
TLS Inhibits RNA Polymerase III Transcription (cid:1) (2009) (1)
A journey to the end of the message (2015) (1)
The Spliced Messenger RNAs of Adenovirus-2 (1979) (1)
SYNTHESIS OF ADENOVIRUS 2 RNA in vitro: PROPERTIES OF THE MAJOR LATER TRANSCRIPT AND ITS PROMOTER (1980) (0)
Crystal structure of HAT domain of murine CstF-77 (2007) (0)
Transcription | mRNA Polyadenylation in Eukaryotes (2021) (0)
15 – Reflections on Style in Physics (1987) (0)
Terri Grodzicker and the making of Genes & Development (2023) (0)
Weighing the intangibles of an aviation career (2005) (0)
Antagonists of the vitronectin-receptors (2000) (0)
RNA splicing. Question of commitment. (1993) (0)
WHAT WE SEE FROM OUR SIDE (2005) (0)
Workshop Session - The Red Bead Experiment (2019) (0)
Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation (2020) (0)
CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1 (2000) (0)
Abstracts of papers presented at the 1997 meeting on Eukaryotic mRNA Processing August 20-August 24, 1997 (1997) (0)
A nucleolar long "non-coding" RNA encodes a novel protein that functions in response to stress. (2023) (0)
The Role of Cotranscriptional Recruitment of RNA‐Binding Proteins in the Maintenance of Genomic Stability (2013) (0)
CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2 (2000) (0)
Abstracts of papers presented at the 1991 Meeting on RNA Processing, May 15-May 19, 1991 (1991) (0)
TRANSCRIPTION OF ANIMAL VIRUS GENES IN VITRO1 (1980) (0)
CHAPTER 320 – Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death (2003) (0)
Corrigendum (2016) (0)
Ssu 72 phosphorylated at Ser 7 in the active site of the CTD phosphatase An unexpected binding mode for a Pol II CTD peptide (2012) (0)
Transcription and RNA processing factors play complex roles in DT40 cells. (2006) (0)
635 Transcription and RNA Processing: links to cancer (2010) (0)
In vitro analysis of transcriptional activators and polyadenylation. (2014) (0)
CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2 (2000) (0)
Corrigendum (2022) (0)
Alternative Splicing of Pyruvate Kinase mRNA Turning on a Fuel Switch of Cancer : hnRNP Proteins Regulate (2010) (0)
The transcriptional coactivator sub1 has a role in transcription elongation (2008) (0)
Table of Contents (1996) (0)
Abstract IA6: Misregulation of pre-mRNA splicing in cancer (2013) (0)
Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting Pre-mRNA 3 (cid:2) Cleavage (2002) (0)
Structural studies of pre-mRNA 3′-end processing (2008) (0)
Multiple Functional DomainsofHumanU2SmallNuclear RNA:Strengthening Conserved StemICanBlockSplicing (1992) (0)
The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death (2010) (0)
Corrigendum: TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency. (2019) (0)
DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. (2022) (0)
can block splicing. nuclear RNA: strengthening conserved stem I Multiple functional domains of human U2 small (2013) (0)
PNAS Plus Significance Statements (2013) (0)
Crystal Structure of the HAT-C domain of murine CstF-77 (2007) (0)
On the nature of β-galactosidase synthesized by the DNA-directed cell-free system (2004) (0)
Polyadenylation of mRNA precursors: mechanism, regulation and connections with other cellular processes (2007) (0)
Abstracts of papers presented at the 1999 Meeting on Eukaryotic mRNA Processing, August 25-August 29, 1999 (1999) (0)
Per Arnoldi 250 posters etc. (2004) (0)
Interconnections between the transcription and processing of mRNA precursors (2008) (0)
Climate and the Carbon Cycle (2017) (0)
A functional .mRNA polyadeny.lation signal is required for transcnpnon termination by RNA polymerase II (2007) (0)
SYNTHESIS AND PROCESSING OF ADENOVIRUS 2 RNA IN VITRO (1979) (0)
Abstracts of papers presented at the 1990 Meeting on RNA Processing, May 16-May 20, 1990 (1990) (0)

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What Schools Are Affiliated With James L. Manley?

James L. Manley is affiliated with the following schools:

University of California, Berkeley
Princeton University
Stanford University
University of Glasgow
Columbia University