James A. Lake
#22,962
Most Influential Person Now
Professor of Molecular, Cell, and Developmental Biology and of Human Genetics
James A. Lake's AcademicInfluence.com Rankings
James A. Lakebiology Degrees
Biology
#739
World Rank
#1284
Historical Rank
#403
USA Rank
Developmental Biology
#39
World Rank
#43
Historical Rank
#16
USA Rank
Cell Biology
#86
World Rank
#91
Historical Rank
#35
USA Rank
Molecular Biology
#255
World Rank
#259
Historical Rank
#107
USA Rank
Download Badge
Biology
Why Is James A. Lake Influential?
(Suggest an Edit or Addition)According to Wikipedia, James A. Lake is an American evolutionary biologist and a Distinguished Professor of Molecular, Cell, and Developmental Biology and of Human Genetics at UCLA. Lake is best known for the New Animal Phylogeny and for the first three-dimensional structure of the ribosome. He has also made significant contributions to understanding genome evolution across all kingdoms of life, including discovering informational and operational genes, elucidating the complexity hypothesis for gene transfer, rooting the tree of life, and understanding the early transition from prokaryotic to eukaryotic life.
James A. Lake's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evidence for a clade of nematodes, arthropods and other moulting animals (1997) (1501)
- Horizontal gene transfer among genomes: the complexity hypothesis. (1999) (1163)
- Genomic evidence for two functionally distinct gene classes. (1998) (530)
- Evidence from 18S ribosomal DNA that the lophophorates are protostome animals (1995) (518)
- The ring of life provides evidence for a genome fusion origin of eukaryotes (2004) (499)
- Reconstructing evolutionary trees from DNA and protein sequences: paralinear distances. (1994) (427)
- A rate-independent technique for analysis of nucleic acid sequences: evolutionary parsimony. (1987) (405)
- An iterative method of slit‐correcting small angle X‐ray data (1967) (347)
- Horizontal gene transfer accelerates genome innovation and evolution. (2003) (337)
- Evidence that eukaryotes and eocyte prokaryotes are immediate relatives. (1992) (327)
- Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences (1988) (304)
- Eocytes: a new ribosome structure indicates a kingdom with a close relationship to eukaryotes. (1984) (254)
- Ribosome structure determined by electron microscopy of Escherichia coli small subunits, large subunits and monomeric ribosomes. (1976) (240)
- Horizontal gene transfer in microbial genome evolution. (2002) (199)
- The order of sequence alignment can bias the selection of tree topology. (1991) (157)
- Was the nucleus the first endosymbiont? (1994) (155)
- Evolution of RNA editing in kinetoplastid protozoa (1994) (137)
- Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: immune mapping of the nascent chain. (1982) (127)
- Evolving ribosome structure: domains in archaebacteria, eubacteria, eocytes and eukaryotes. (1985) (126)
- Origin of the Metazoa. (1990) (124)
- Ribosomal proteins L7/L12 localized at a single region of the large subunit by immune electron microscopy. (1978) (107)
- DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote (1993) (90)
- Aminoacyl-tRNA binding at the recognition site is the first step of the elongation cycle of protein synthesis. (1977) (90)
- Deriving the genomic tree of life in the presence of horizontal gene transfer: conditioned reconstruction. (2004) (88)
- Evidence excluding the root of the tree of life from the actinobacteria. (2007) (87)
- Ribosomal proteins S5, S11, S13 and S19 localized by electron microscopy of antibody-labeled subunits. (1975) (86)
- Eubacteria, halobacteria, and the origin of photosynthesis: the photocytes. (1985) (83)
- Decoding the genomic tree of life (2005) (80)
- A minimal ribosomal RNA: sequence and secondary structure of the 9S kinetoplast ribosomal RNA from Leishmania tarentolae. (1985) (74)
- Mix and Match in the Tree of Life (1999) (74)
- Evidence for an early prokaryotic endosymbiosis (2009) (69)
- Genome beginnings: rooting the tree of life (2009) (68)
- Evolution of parasitism: kinetoplastid protozoan history reconstructed from mitochondrial rRNA gene sequences. (1991) (63)
- On the conformation of yeast transfer RNA. (1968) (58)
- Ribosome Structure, Function, and Evolution: Mapping Ribosomal RNA, Proteins, and Functional Sites in Three Dimensions (1986) (58)
- Evolution of parasitism: kinetoplastid protozoan history reconstructed from mitochondrial rRNA gene sequences. (1988) (54)
- Mapping evolution with ribosome structure: intralineage constancy and interlineage variation. (1982) (53)
- Evidence for a gram-positive, eubacterial root of the tree of life. (2007) (53)
- Primary sequence and partial secondary structure of the 12S kinetoplast (mitochondrial) ribosomal RNA from Leishmania tarentolae: conservation of peptidyl-transferase structural elements. (1985) (52)
- A unique secondary folding pattern for 5S RNA corresponds to the lowest energy homologous secondary structure in 17 different prokaryotes. (1981) (51)
- An ancestral nuclear protein assembly: Crystal structure of the Methanopyrus kandleri histone (2001) (51)
- Purification and characterization of DNA topoisomerase V. An enzyme from the hyperthermophilic prokaryote Methanopyrus kandleri that resembles eukaryotic topoisomerase I. (1994) (50)
- Tracing origins with molecular sequences: metazoan and eukaryotic beginnings. (1991) (50)
- Evidence for an early prokaryotic origin of histones H2A and H4 prior to the emergence of eukaryotes. (1998) (47)
- Rooting the tree of life using nonubiquitous genes. (2007) (46)
- DNA hybridization electron microscopy: ribosomal RNA nucleotides 1392-1407 are exposed in the cleft of the small subunit. (1986) (45)
- Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes (1983) (45)
- A type IB topoisomerase with DNA repair activities (2001) (45)
- Bayesian hypothesis testing of four-taxon topologies using molecular sequence data. (1996) (44)
- DNA-hybridization electron microscopy. Localization of five regions of 16 S rRNA on the surface of 30 S ribosomal subunits. (1990) (44)
- Localization of Escherichia coli ribosomal proteins S4 and S14 by electron microscopy of antibody-labeled subunits. (1974) (44)
- DNA-hybridization electron microscopy tertiary structure of 16 S rRNA. (1990) (43)
- Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae (2015) (43)
- Ribosomal proteins L1, L17 and L27 from Escherichia coli localized at single sites on the large subunit by immune electron microscopy. (1981) (43)
- A new ribosome structure. (1984) (42)
- Three-dimensional structure of the chromatoid body helix of Entamoeba invadens. (1972) (42)
- Ribosomal proteins S3, S6, S8 and S10 of Escherichia coli localized on the external surface of the small subunit by immune electron microscopy. (1981) (42)
- The network of life: genome beginnings and evolution (2009) (41)
- Isolation of ribosomes and polysomes. (2015) (38)
- Elongation factor Tu localized on the exterior surface of the small ribosomal subunit. (1986) (37)
- Evidence for a new root of the tree of life. (2008) (36)
- Phylogeny of Methanopyrus kandleri based on methyl coenzyme M reductase operons. (1996) (35)
- Next-generation nuclear power. (2002) (33)
- Ribosomal subunit orientations determined in the monomeric ribosome by single and by double-labeling immune electron microscopy. (1982) (32)
- Localization of eukaryotic initiation factor 3 on native small ribosomal subunits. (1978) (31)
- A reverse gyrase with an unusual structure. A type I DNA topoisomerase from the hyperthermophile Methanopyrus kandleri is a two-subunit protein. (1994) (31)
- The Fourth Generation of Nuclear Power (2000) (30)
- Caulobacter crescentus bacteriophage phiCbK: structure and in vitro self-assembly of the tail. (1973) (30)
- The Evolution of Eukaryotes (2007) (30)
- Evidence that the root of the tree of life is not within the Archaea. (2006) (29)
- Evolution of the Multicellular Animals (1998) (29)
- Origin of the eukaryotic nucleus: eukaryotes and eocytes are genotypically related. (1989) (27)
- Electron Microscopy of Specific Proteins: Three-Dimensional Mapping of Ribosomal Proteins Using Antibody Labels (1978) (25)
- Ribosome evolution: the structural bases of protein synthesis in archaebacteria, eubacteria, and eukaryotes. (1983) (25)
- The L7/L12 stalk, a conserved feature of the prokaryotic ribosome, is attached to the large subunit through its N terminus. (1981) (24)
- Ribosomal crystalline arrays of large subunits from Escherichia coli. (1982) (24)
- Mapping the three-dimensional locations of ribosomal RNA and proteins. (1992) (22)
- Optimally recovering rate variation information from genomes and sequences: pattern filtering. (1998) (22)
- Phylogenetic analysis and comparative genomics (1998) (21)
- Ribosomal protein S4 is an internal protein: Localization by immunoelectron microscopy on protein-deficient subribosomal particles. (1982) (21)
- Prokaryotes and archaebacteria are not monophyletic: rate invariant analysis of rRNA genes indicates that eukaryotes and eocytes form a monophyletic taxon. (1987) (21)
- Structure and protein distribution for the capsid of Caulobacter crescentus bacteriophage phiCbK. (1974) (21)
- RIBOSOME STRUCTURE AND FUNCTIONAL SITES (1978) (20)
- DNA Enzymology above 100 °C. (1995) (20)
- Phylogenetic inference: how much evolutionary history is knowable? (1997) (19)
- Helical arrays of Escherichia coli small ribosomal subunits produced in vitro. (1979) (19)
- The phylogeny of Methanopyrus kandleri. (1996) (19)
- The transorientation hypothesis for codon recognition during protein synthesis (2002) (18)
- The Deep Roots of the Rings of Life (2013) (17)
- Ribosome Structure as Studied by Electron Microscopy (1974) (17)
- Lophophorate phylogeny. Authors' reply (1996) (15)
- Ribosome structure: hand determination by electron microscopy of 30 S subunits. (1979) (14)
- Determining evolutionary distances from highly diverged nucleic acid sequences: Operator metrics (2005) (14)
- Calculating the probability of multitaxon evolutionary trees: bootstrappers Gambit. (1995) (14)
- Evolving ribosome structure: Domains in archaebacteria, eubacteria, and eucaryotes (1983) (13)
- An alternative to archaebacterial dogma (1986) (13)
- Archaebacterial or eocyte tree? (1990) (12)
- [12] Practical aspects of immune electron microscopy (1979) (11)
- Ribosome structure: three-dimensional distribution of proteins S14 and S4. (1974) (11)
- Bacteriophage Structure: Determination of Head-Tail Symmetry Mismatch for Caulobacter crescentus Phage [unknown]CbK (1974) (11)
- Rings Reconcile Genotypic and Phenotypic Evolution within the Proteobacteria (2015) (11)
- In defence of bacterial phylogeny (1986) (10)
- [15] Topoisomerase V from Methanopyrus kandleri (2001) (10)
- Mapping evolution with three dimensional ribosome structure (1986) (9)
- Reconstructing evolutionary graphs: 3D parsimony. (2008) (9)
- Reconstruction of three-dimensional structures from sectioned helices by deconvolution of partial data. (1972) (9)
- Yeast Transfer RNA: A Small-Angle X-Ray Study (1967) (9)
- Lynn Margulis (1938–2011) (2011) (9)
- Gene structure prediction in syntenic DNA segments. (2003) (9)
- Eukaryotic origins (2015) (8)
- Unusual rRNA-linked complex of 50S ribosomal subunits isolated from an Escherichia coli RNase III mutant (1984) (8)
- Elongation factor Tu ternary complex binds to small ribosomal subunits in a functionally active state. (1984) (8)
- Practical aspects of immune electron microscopy. (1979) (7)
- Non‐clonal evolution of microbes (2003) (7)
- Phylogenetic analysis & comparative genomics (1998) (7)
- Ultrahigh flux reactor design probing the limits of plate fuel technology (1986) (6)
- The ribosome: Structure, function and evolution (1991) (6)
- DNA enzymology above 100 degrees C. Topoisomerase V unlinks circular DNA at 80-122 degrees C. (1995) (6)
- Response: Lophophorate Phylogeny (1996) (6)
- Purification of 70S ribosomes. (2015) (6)
- Bacteriophage structure: determination of head-tail symmetry mismatch for Caulobacter crescentus phage phiCbK. (1974) (6)
- Ribosome Structure and tRNA Binding Sites (1979) (6)
- Sustainable soil improvement and water use in agriculture: CCU enabling technologies afford an innovative approach (2019) (6)
- Purification of polysomes. (2015) (6)
- Packing of 70 S Ribosomes in dimers formed at low ionic strength. Images of an unusual ribosome projection. (1982) (6)
- Rooting Gene Trees without Outgroups: EP Rooting (2012) (5)
- RECONSTITUTION OF A MINIMAL SMALL RIBOSOMAL SUBUNIT (1993) (5)
- THE CASE FOR NUCLEAR POWER. (2002) (4)
- BREEDING RATIO AND DOUBLING TIME CHARACTERISTICS OF THE CLINCH RIVER BREEDER REACTOR (1975) (4)
- Foundations for the fourth generation of nuclear power (2000) (4)
- Inference for phylogenies under a hybrid parsimony method: evolutionary-symmetric transversion parsimony. (1997) (3)
- FUEL AND BLANKET MANAGEMENT FOR THE CLINCH RIVER BREEDER REACTOR (1975) (3)
- Topoisomerase V from Methanopyrus kandleri. (2001) (3)
- Measurement of steady-state, space dependent thermal neutron spectra in beryllium (1972) (2)
- Dissociation of ribosomes into large and small subunits. (2015) (2)
- Localization of Escherichia coli Ribosomal Proteins S 4 and S 14 by Electron Microscopy of Antibody-Labeled Subunits ( Bacillus stearothermophilus / IgG antibody / ribosome topography / reconstitution ) (2)
- Neutronics design of a medical therapy reactor (1988) (2)
- Uncovering the Genomic Origins of Life (2018) (2)
- Conceptual design of a medical therapy reactor facility (1987) (1)
- Inherent safety for a liquid-metal reactor (1984) (1)
- Comparison of single and split core concepts for the Advanced Neutron Source (1988) (1)
- Methanococcus genome [1] (1996) (1)
- Chloroflexus aurantiacus has 30S ribosomal subunits of the eubacterial type (1983) (1)
- Law and Mineral Wealth: The Legal Profile of the Wisconsin Mining Industry (1962) (1)
- Evidence for a specific phylogenetic relationship between the methanogens Methanococcus thermolithotrophicus and Methanothermus fervidus, and the sulfur respiring Thermoproteus tenax (1986) (1)
- Comments on “An Axially Heterogeneous Core Concept for Large LMFBRs and Its HCDA Behavior” (1984) (1)
- The ribosome. (1981) (1)
- Medical therapy reactor preconceptual design studies (1988) (1)
- Protein synthesis. (1978) (1)
- A minimal ribosomal RNA: Sequenl 9S kinetoplast ribosomal RNA fron (kinetoplast DNA/mitochondrial ribosomal RNA/maxicircle DNA/tr. (2016) (0)
- Dual annular rotating [open quotes]windowed[close quotes] nuclear reflector reactor control system (1994) (0)
- 18S rDNA from lophophorates. Authors' reply (1995) (0)
- Structure and properties of hyperthermophilic DNA topoisomerases (1994) (0)
- Protein Synthesis: Molecular Mechanisms of Protein Biosynthesis . Herbert Weissbach and Sidney Pestka, Eds. Academic Press, New York, 1977. xiv, 722 pp., illus. $55. Molecular Biology. (1978) (0)
- Escheat, Federalism and State Boundaries (1963) (0)
- Nuclear criticality safety analysis for remotely handled transuranic waste at the Waste Isolation Pilot Plant (1984) (0)
- EVOLUTION OF RIBOSOMAL STRUCTURE AND FUNCTION (1983) (0)
- Nucleic Acids Research (2016) (0)
- SPACE-DEPENDENT STEADY-STATE THERMAL-NEUTRON SPECTRA IN BERYLLIUM ABOVE THE CRITICAL BUCKLING. (1971) (0)
- Nascent Polypeptide Chains Exit the Ribosome in the Same Relative in Both Eucaryotes and Procaryotes Position (2002) (0)
- MEASUREMENT OF SPACE-DEPENDENT THERMAL-NEUTRON SPECTRA IN SMALL BERYLLIUM ASSEMBLIES. (1972) (0)
- Evolution Mapping evolution with ribosome structure : Intralineage constancy and interlineage variation ( archaebacterial bill / eukaryotic lobes / unrooted dendrogram / endokaryotic hypothesis ) (2018) (0)
- 94 12291 – Structure Discovery in Biology : Motifs , Networks & Phylogenies (2012) (0)
- Colloquium Decoding the genomic tree of life (2005) (0)
- The Big Bang (2006) (0)
- Genome evolution and the impact of the physical environment (2003) (0)
- Mapping the Ribosomal Exit Site of the Nascent Polypeptide Chain by Immune Electron Microscopy (1981) (0)
- CRYSTAL STRUCTURE OF THE HISTONE FROM METHANOPYRUS KANDLERI (2001) (0)
- Ultra high flux reactor design: probing the limits of plate fuel technology. [Thermal neutron flux exceeding 10/sup 16/ n/cm/sup 2/. s] (1985) (0)
- Intrinsic reactivity feedback characteristics for safety analysis of heterogeneous and homogeneous LMBFR core designs (1982) (0)
- STRUCTURE: DOMAINS IN ARCI1(AEBACTERIA, EUBA.CTERIA, EOCYTES AND EUKA.RYOTES (1985) (0)
- A Model for a Five-Prime Stacked tRNA (2002) (0)
- Mapping the early evolution of cells with rrna sequences and structure (1986) (0)
- The effect of industrial practices on stream sediments, and the impact of these sediments on the geochemistry of a wetland (1997) (0)
- Influence of control rod worth interactions on LMFBR control systems design (1980) (0)
- Constitutionality of Initiative 300: An Answer (1984) (0)
- Methanococcus Genome (1996) (0)
- From ribosome structures to genes and genomes : the evolution of the eocyte tree (2015) (0)
- Effect of fuel design and material on LMFBR terminated transient overpower performance (1979) (0)
- and Reconstructing Phylogenetic Rings and Their Application (2016) (0)
- Ternary Complex Docked in the Decoding Site of the 30S Ribosomal Subunit (2002) (0)
- Crystalline arrays of large ribosomal subunits from E. coli produced in vitro (1981) (0)
- Parameter trade-off studies for the ultrahigh flux double donut reactor (1987) (0)
- Codon recognition and decoding: the transorientation hypothesis. (2001) (0)
- IBM-PC based reactor neutronics analysis package (1985) (0)
- Ultrahigh flux double donut research reactor design (1986) (0)
- Response : 18 S rDNA from Lophophorates (1995) (0)
- Heterogeneous oxide reference, transmuter, denatured core designs. [Proliferation-resistant large core design study] (1979) (0)
- Degraded LMFBR core cooling under hypothetical core support failure conditions (1984) (0)
- Rings Reconcile Genotypic and Phenotypic Evolution within the Proteobacteria (2016) (0)
- Heat transfer for ultrahigh flux reactor (1987) (0)
- Negro Segregation in Nebraska Schools — 1860 to 1870 (1953) (0)
This paper list is powered by the following services:
Other Resources About James A. Lake
What Schools Are Affiliated With James A. Lake?
James A. Lake is affiliated with the following schools:
