James R. Halpert
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Molecular Biology
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Biochemistry
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Chemistry Biology
James R. Halpert's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry Stanford University
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(Suggest an Edit or Addition)James R. Halpert's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. (1985) (1309)
- The genetic determinants of the CYP3A5 polymorphism. (2001) (685)
- An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution (2003) (339)
- Structure of Mammalian Cytochrome P450 2B4 Complexed with 4-(4-Chlorophenyl)imidazole at 1.9-Å Resolution (2004) (287)
- Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics. (1998) (228)
- Identification and functional characterization of eight CYP3A4 protein variants. (2001) (226)
- cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (2001) (223)
- Selective inhibitors of cytochromes P450. (1994) (214)
- Toxicology of thiono-sulfur compounds. (1982) (168)
- Structure of Microsomal Cytochrome P450 2B4 Complexed with the Antifungal Drug Bifonazole (2006) (154)
- Alanine-scanning Mutagenesis of a Putative Substrate Recognition Site in Human Cytochrome P450 3A4 (1997) (150)
- Amino acid sequence of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake). (1975) (150)
- A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function. (2001) (147)
- Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation. (2002) (147)
- Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis. (2001) (144)
- Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity. (2001) (138)
- Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins (2013) (126)
- Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation. (1998) (125)
- Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both? (2008) (117)
- Molecular modeling of cytochrome P450 3A4 (1997) (116)
- Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe. (1998) (115)
- Structural basis of selective cytochrome P450 inhibition. (1995) (108)
- Structures of cytochrome P450 3A4. (2005) (107)
- Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity. (2000) (105)
- Purification, characterization, and pituitary regulation of the sex-specific cytochrome P-450 15 beta-hydroxylase from liver microsomes of untreated female rats. (1984) (102)
- Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization. (2005) (100)
- Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution (2010) (91)
- CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. (2005) (88)
- Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. (2004) (87)
- Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). (1980) (85)
- Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis. (1997) (84)
- Directed Evolution of Mammalian Cytochrome P450 2B1 (2005) (82)
- Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. (1986) (82)
- Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1. (1995) (78)
- Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy. (2003) (76)
- Molecular basis for a functionally unique cytochrome P450IIB1 variant. (1991) (75)
- Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450. (1997) (73)
- Isolation and amino acid sequence of a neurotoxic phospholipase A from the venom of the Australian tiger snake Notechis scutatus scutatus. (1976) (72)
- Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. (2012) (72)
- Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes. (1988) (71)
- Conformational Flexibility of Mammalian Cytochrome P450 2B4 in Binding Imidazole Inhibitors with Different Ring Chemistry and Side Chains (2006) (71)
- Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling. (2003) (69)
- Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol. (1981) (68)
- Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library. (1997) (67)
- Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). (2000) (67)
- Substrate-regulated, cAMP-dependent phosphorylation, denaturation, and degradation of glucocorticoid-inducible rat liver cytochrome P450 3A1. (1994) (66)
- Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR. (2010) (65)
- Analysis of Differential Substrate Selectivities of CYP2B6 and CYP2E1 by Site-Directed Mutagenesis and Molecular Modeling (2003) (65)
- Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase. (1993) (64)
- Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily. (1989) (64)
- Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites. (1994) (63)
- Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe. (2007) (63)
- Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates. (2007) (60)
- Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4. (2002) (59)
- The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4. (2000) (59)
- Evidence for functional and structural multiplicity of pregnenolone-16 alpha-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes. (1987) (59)
- Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling. (2002) (59)
- Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. (2010) (59)
- Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4. (1996) (58)
- Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET)* (2011) (58)
- The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. (2011) (57)
- Molecular basis of P450 inhibition and activation: implications for drug development and drug therapy. (1998) (57)
- Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone. (2013) (57)
- Structure-function analysis of cytochromes P450 2B. (2007) (57)
- Interactions among Cytochromes P450 in Microsomal Membranes (2014) (56)
- Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies. (1995) (56)
- Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1. (1992) (54)
- 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11. (1999) (54)
- Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration. (2006) (53)
- A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5* (2003) (53)
- Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography* (2010) (52)
- On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. (1985) (52)
- cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. (1990) (51)
- Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes. (2001) (50)
- Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro. (1983) (50)
- Possible Pathway(s) of Metyrapone Egress from the Active Site of Cytochrome P450 3A4: A Molecular Dynamics Simulation (2007) (50)
- Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity. (1994) (48)
- POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION (2005) (48)
- Application of 3-dimensional homology modeling of cytochrome P450 2B1 for interpretation of site-directed mutagenesis results. (1994) (48)
- Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5. (1994) (48)
- Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains (2011) (47)
- Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. (2006) (45)
- ROLE OF CYTOCHROME B5 IN MODULATING PEROXIDE-SUPPORTED CYP3A4 ACTIVITY: EVIDENCE FOR A CONFORMATIONAL TRANSITION AND CYTOCHROME P450 HETEROGENEITY (2005) (44)
- Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis (2006) (43)
- Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. (2007) (43)
- Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1. (2002) (43)
- Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . (2010) (42)
- Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo. (1985) (42)
- Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. (2007) (41)
- cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily. (1991) (39)
- Functional role of residues in the helix B' region of cytochrome P450 2B1. (2005) (39)
- Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning. (2009) (39)
- Directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts (2005) (38)
- Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling. (1999) (38)
- Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes. (2000) (38)
- Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants. (1998) (37)
- Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. (1994) (36)
- Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles. (2001) (36)
- Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. (2011) (36)
- Investigation by site‐directed mutagenesis of the role of cytochrome P450 2B4 non‐active‐site residues in protein–ligand interactions based on crystal structures of the ligand‐bound enzyme (2012) (35)
- Further studies of the suicide inactivation of purified rat liver cytochrome P-450 by chloramphenicol. (1982) (35)
- Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation. (2001) (35)
- Structure of mammalian cytochrome P450 2B4 (2000) (35)
- Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes. (1996) (35)
- Plasticity of CYP2B enzymes: structural and solution biophysical methods. (2012) (35)
- Xylene induces a cytochrome P-450 isozyme in rat liver similar to the major isozyme induced by phenobarbital. (1983) (34)
- Halogen‐π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human P450 2B6 Substrate Selectivity. (2017) (34)
- Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations (2014) (34)
- Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6. (2013) (34)
- Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility. (1999) (34)
- Role of Residue 363 and 206 in Conversion of Cytochrome P450 2B1 from a Steroid 16-Hydroxylase to a 15α-Hydroxylase (1994) (33)
- An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF. (2004) (33)
- Dichloromethyl compounds as mechanism-based inactivators of rat liver cytochromes P-450 in vitro. (1986) (32)
- Structure and Function of Cytochromes P450 2B: From Mechanism-Based Inactivators to X-Ray Crystal Structures and Back (2011) (32)
- Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. (2013) (32)
- Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs (2009) (32)
- Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane. (1986) (32)
- The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins. (2001) (31)
- Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase. (1996) (31)
- Institutional Profile: University of California San Diego Pharmacogenomics Education Program (PharmGenEd™): bridging the gap between science and practice. (2011) (30)
- Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. (2007) (30)
- Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes. (1997) (30)
- Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues. (1996) (29)
- The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2. (1988) (29)
- Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes* (2012) (29)
- Secobarbital-mediated Inactivation of Cytochrome P450 2B1 and Its Active Site Mutants (1996) (29)
- Rational Engineering of Human Cytochrome P450 2B6 for Enhanced Expression and Stability: Importance of a Leu264→Phe Substitution (2007) (29)
- Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P-450. (1987) (29)
- Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe. (2005) (29)
- Analogues of chloramphenicol as mechanism-based inactivators of rat liver cytochrome P-450: modifications of the propanediol side chain, the p-nitro group, and the dichloromethyl moiety. (1986) (29)
- Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate. (2002) (29)
- Isolation and incorporation of rabbit liver epoxide hydrase into phospholipid vesicles. (1979) (28)
- Immunochemical detection and quantitation of microsomal cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase in the rat ventral prostate. (1983) (28)
- Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix. (2004) (27)
- Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4. (2008) (27)
- Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11. (1997) (27)
- Reassessment of cytochrome P450 2B2: catalytic specificity and identification of four active site residues. (1997) (27)
- Inactivation of purified rat liver cytochrome P-450 by chloramphenicol. (1980) (26)
- Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. (2003) (25)
- A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET) (2013) (25)
- Amino acid sequence of a postsynaptic neurotoxin from the venom of the Australian tiger snake Notechis scutatus scutatus. (1979) (25)
- Comparison of In Vitro Metabolism of Ticlopidine by Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 (2011) (25)
- Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. (2008) (25)
- Stoichiometry of 7‐ethoxycoumarin metabolism by cytochrome P450 2B1 wild‐type and five active‐site mutants (1997) (25)
- Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. (2007) (25)
- Dissecting the thermodynamics and cooperativity of ligand binding in cytochrome P450eryF. (2007) (24)
- The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats. (1990) (24)
- Functional expression of mammalian cytochromes P450IIB in the yeast Saccharomyces cerevisiae. (1991) (24)
- Inactivation of rat liver cytochrome P-450 by the suicide substrates parathion and chloramphenicol. (1981) (24)
- Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA. (2008) (23)
- Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions (2009) (23)
- Inactivation of cytochromes P450 2B protects against cocaine-mediated toxicity in rat liver slices. (1994) (23)
- Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis. (2004) (22)
- Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334. (2010) (22)
- Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy. (2016) (22)
- Chemically reactive metabolites as suicide enzyme inhibitors. (1983) (22)
- Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors. (2008) (22)
- Distinct binding of cholesterol and 5β-cholestane-3α,7α,12α-triol to cytochrome P450 27A1 : Evidence from modeling and site-directed mutagenesis studies (2006) (22)
- Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. (2006) (22)
- Significance of glycine 478 in the metabolism of N-benzyl-1-aminobenzotriazole to reactive intermediates by cytochrome P450 2B1. (1997) (22)
- Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450. (2006) (21)
- MUTATIONS OUTSIDE OF THE ACTIVE SITE ENHANCE THE METABOLISM OF SEVERAL SUBSTRATES, INCLUDING THE ANTICANCER PRODRUGS CYCLOPHOSPHAMIDE AND IFOSFAMIDE* (2005) (21)
- Selective inactivation of rat liver cytochromes P-450 by 21-chlorinated steroids. (1989) (21)
- Dithionite-supported hydroxylation of palmitic acid by cytochrome P450BM-3. (1996) (21)
- Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. (1999) (21)
- Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site. (2002) (20)
- Selective inactivation of four rat liver microsomal androstenedione hydroxylases by chloramphenicol analogs. (1988) (19)
- Cloning, sequencing, and functional studies of phenobarbital-inducible forms of cytochrome P450 2B and 4B expressed in rabbit kidney. (1993) (18)
- Selective suppression of rat hepatic cytochrome P450 2C11 by chloramphenicol. (1994) (18)
- Cytochrome P-450-dependent covalent binding of 1,1,2,2-tetrachloroethane in vitro. (1982) (18)
- Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues. (1998) (18)
- Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene. (2001) (18)
- Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice. (1999) (17)
- Isolation of A non‐neurotoxic, non‐enzymatic phospholipase a homologue from the venom of the australian tiger snake Notechis scutatus scutatus (1976) (17)
- Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism. (1998) (17)
- Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism (2016) (17)
- The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes. (2014) (16)
- Cytochrome P-450-dependent metabolism of 1,1,2,2-tetrachloroethane to dichloroacetic acid in vitro. (1981) (16)
- Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida. (2014) (16)
- Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism. (1994) (15)
- Topological analysis of the active sites of cytochromes P450IIB4 (rabbit), P450IIB10 (mouse), and P450IIB11 (dog) by in situ rearrangement of phenyl-iron complexes. (1992) (15)
- A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States (2013) (15)
- Production of superoxide anion radicals during the oxidative metabolism of amino-chloramphenicol. (1986) (15)
- Specific inactivation by 17 beta-substituted steroids of rabbit and rat liver cytochromes P-450 responsible for progesterone 21-hydroxylation. (1989) (15)
- 7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe. (2002) (15)
- Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form(s) of rat liver cytochrome P-450. (1990) (14)
- Identification and Analysis of Conserved Sequence Motifs in Cytochrome P450 Family 2 (2008) (14)
- Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11. (1996) (14)
- Thermodynamics of Ligand Binding to P450 2B4 and P450eryF Studied by Isothermal Titration Calorimetry (2007) (14)
- Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison (2015) (13)
- Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11. (1993) (13)
- Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity (2011) (13)
- Mechanism-based inactivation of bovine adrenal cytochromes P450 C-21 and P450 17 alpha by 17 beta-substituted steroids. (1991) (13)
- Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11). (1995) (13)
- Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies. (2006) (12)
- Escherichia coli expression and substrate specificities of canine cytochrome P450 3A12 and rabbit cytochrome P450 3A6. (1996) (12)
- Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores (2018) (12)
- NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation. (2011) (12)
- Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis. (1995) (12)
- Suppression of rat hepatic microsomal cytochromes P450 by cyclophosphamide is correlated with plasma thyroid hormone levels and displays differential strain sensitivity. (1996) (11)
- Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole. (1995) (11)
- Structural Nature of Presynaptic Neurotoxins from the Venoms of the Australian Tiger Snake, Notechis scutatus scutatus, and the Taipan Oxyuranus scutellatus scutellatus (1976) (11)
- Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26. (1999) (11)
- Rat lung and liver cytochrome P-450 isozymes involved in the hydroxylation of m-xylene. (1986) (11)
- Structure and function of neuro- and myotoxic phospholipases: modification with ethoxyformic anhydride of notechis II-5 from the venom of the Australian tiger snake Notechis scutatus scutatus. (1979) (10)
- X‐ray Crystal Structure of the Cytochrome P450 2B4 Active Site Mutant F297A in Complex with Clopidogrel: Insights into Compensatory Rearrangements of the Binding Pocket (2013) (10)
- Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog. (1991) (10)
- ROLE OF CYTOCHROME B 5 IN MODULATING PEROXIDE-SUPPORTED CYP 3 A 4 ACTIVITY : EVIDENCE FOR A CONFORMATIONAL TRANSITION AND CYTOCHROME P 450 HETEROGENEITY (2005) (9)
- Structure of mammalian cytochrome P450 2B4 with bound 4-(4-chlorophenyl)imidazole (2004) (9)
- Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. (2016) (9)
- CYP261 enzymes from deep sea bacteria: A clue to conformational heterogeneity in cytochromes P450 (2013) (9)
- The draft genome sequence and annotation of the desert woodrat Neotoma lepida (2016) (9)
- Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol. (1998) (9)
- An In Vivo Assay for Elucidating the Importance of Cytochromes P450 for the Ability of a Wild Mammalian Herbivore (Neotoma lepida) to Consume Toxic Plants (2013) (8)
- Effect of chloramphenicol administration in vivo on cytochrome P-450-dependent monooxygenase activities in liver microsomes from uninduced male rats. (1988) (8)
- Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. (2016) (8)
- Dihalomethyl compounds as mechanism-based inactivators of cytochromes P450. (1991) (7)
- Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection (2009) (7)
- Using the Specialization Framework to Determine Degree of Dietary Specialization in a Herbivorous Woodrat (2015) (7)
- Catalytic properties of an expressed cytochrome P450 2B1 from a Wistar-Kyoto rat liver cDNA library. (1998) (6)
- Rational Re-Engineering of the O-Dealkylation of 7-Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida. (2017) (6)
- Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation. (1988) (6)
- Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes. (2015) (5)
- Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase. (1994) (5)
- Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog (2018) (5)
- cDNA Cloning and Initial Characterization of CYP 3 A 43 , a Novel Human Cytochrome P 4501 (2001) (5)
- Selective inhibition by chloramphenicol of cytochrome P-450 isozymes in rat lung and liver involved in the hydroxylation of n-hexane. (1984) (5)
- Identification and Analysis of Conserved Sequence Motifs in Cytochrome P 450 Family 2 FUNCTIONAL AND STRUCTURAL ROLE OF A MOTIF 187 RFDYKD 192 IN CYP 2 B ENZYMES * (2008) (4)
- Cytochrome P450 2B diversity in a dietary specialist—the red tree vole (Arborimus longicaudus) (2018) (4)
- Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes. (2001) (4)
- Amino Acid Residues Critical for Differential Inhibition of CYP 2 B 4 , CYP 2 B 5 , and CYP 2 B 1 by Phenylimidazoles (2001) (4)
- Mechanism-based inactivation of the major beta-naphthoflavone-inducible isozyme of rat liver cytochrome P-450 by the chloramphenicol analog N-(2-p-nitrophenethyl)dichloroacetamide. (1987) (4)
- Cytochrome P450 in Laboratory Animal Species (2003) (4)
- Covalent binding of benzo[a]pyrene to cytochrome P-450 beta NF-B2 and other proteins in reconstituted mixed-function oxidase systems. (1984) (3)
- INDUCTION OF CYTOCHROME P-450 ENZYMES AFTER REPEATED EXPOSURE TO 4-VINYLCYCLOHEXENE IN B 6 C 3 F 1 MICE (1999) (3)
- DIFFERENTIAL OXIDATION OF MIFEPRISTONE BY CYTOCHROMES P 450 3 A 4 AND 3 A 5 : SELECTIVE INACTIVATION OF P 450 3 A 4 (2002) (3)
- TOPOLOGICAL CHANGES IN THE CYP 3 A 4 ACTIVE SITE PROBED WITH PHENYLDIAZENE : EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P 450 REDUCTASE AND CYTOCHROME B 5 AND OF SITE-DIRECTED MUTAGENESIS (2003) (3)
- MOLECULAR BASIS OF P 450 INHIBITION AND ACTIVATION Implications for Drug Development and Drug Therapy (1998) (3)
- Engineering of Cytochrome P 450 3 A 4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis (2006) (3)
- Inactivation of Escherichia coli-expressed rabbit cytochrome P-450 2C enzymes by 17 beta-substituted steroids. (1995) (2)
- Porphyrinogenic effects in chick embryo liver cell culture of chloramphenicol analogues that are mechanism-based inactivators of cytochrome P-450. (1991) (2)
- Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes. (2017) (2)
- A 4 for Enhanced Peroxide-mediated Substrate Oxidation Using Directed Evolution and Site-directed Mutagenesis (2006) (2)
- INACTIVATION OF CYTOCHROME P 450 S 2 B 1 , 2 B 4 , 2 B 6 , AND 2 B 11 BY ARYLALKYNES (1997) (2)
- The effect of chloramphenicol on the metabolism of 7,12-dimethylbenz[a]-anthracene in rat adrenal and liver microsomes. (1983) (2)
- Cytochrome P-450 as a target of biological reactive intermediates. (1991) (2)
- Correction to Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations (2016) (1)
- So many roads traveled: A career in science and administration (2020) (1)
- Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond (2022) (1)
- Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist (Neotoma stephensi) and a generalist (Neotoma albigula) (2020) (1)
- Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes P-450 responsible for progesterone 21-hydroxylation. (1989) (1)
- The Evolution of Drug Metabolism and Disposition: A Perspective From the Editors (2022) (1)
- Cytochromes P450. Structure, Function, and Mechanism By David F. Lewis. Taylor & Francis, London and Bristol, PA. 1996. xxi + 348 pp. 17.5 × 25 cm. ISBN 0-7484-0443-0. $150.00. (1997) (1)
- Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel (2010) (0)
- Homotropic Cooperativity During The Mechanism‐Based Inactivation Of Cytochrome P450 2B4 By 9‐Ethynylphenanthrene (2012) (0)
- Conformational plasticity of cytochrome P450 2B4: crystallographic and solution studies (2006) (0)
- Single ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole (2009) (0)
- Structure of Cytochrome P450 2B4 with Bound Bifonazole (2005) (0)
- Peripheral Ligand Binding and Allostery in Cytochrome P450 3A4 (2012) (0)
- Using NMR Derived Structural Information Complemented by Molecular Docking and MM/GBSA Rescoring to Mitigate CYP3A4 Time‐Dependent Inhibition (2020) (0)
- Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences. (2022) (0)
- Characterization of a laboratory evolved cytochrome P450 2B1 mutant and its further improvement for enhanced tolerance to organic solvents and temperature and enhanced affinity for hydrogen‐peroxide (2006) (0)
- NMR‐based Structural Model of Rabbit Cytochrome P450 2B4 with the Analgesic Amidopyrine, the Intermediate Desmethylamidopyrine, and its Product Aminoantipyrine: Implications for the Structural Basis of Sequential Metabolism (2010) (0)
- Crystal structure of CYP2B6 (Y226H/K262R) in complex with a monoterpene bornane (2017) (0)
- Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine (2012) (0)
- A Structural Snapshot of Cytochrome P 450 2 B 4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States (2013) (0)
- Structure and function of presynaptic neurotoxins from tiger snake venom : the role of phospholipase A activity (1977) (0)
- Displaced Conformational Equilibrium in a Piezophilic Cytochrome P450 (2010) (0)
- Functional importance of residues located in SRS-1 of CYP3A4 (1999) (0)
- Crystal Structure Of Cytochrome P450 2B35 from Desert Woodrat Neotoma Lepida in complex with 4-(4-chlorophenyl)imidazole (2016) (0)
- Crystal structure of CYP2B6 in complex with an efavirenz analog: From plasticity to PI interactions in CYP2B enzymes (2018) (0)
- Structure-activity relationship of phenoxyaniline congener interactions with cytochrome P450 2B enzymes (2018) (0)
- Dynamics of P450 3A4 Oligomers in Solution (2006) (0)
- Two Conformations of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism‐Based Inactivator tert‐Butylphenylacetylene (2011) (0)
- Structure-Function Analysis of Mammalian CYP 2 B Enzymes Using 7-Substituted Coumarin Derivatives as Probes : Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism s (2016) (0)
- Crystal Structure of human Cytochrome P450 2B6 (Y226H/K262R) in complex with an analog of a drug Efavirenz (2018) (0)
- Structure of CYP2B4 F244W in a ligand free conformation (2016) (0)
- Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-(4-Nitrobenzyl)pyridine. (2011) (0)
- Allosteric mechanisms of substrate binding in cytochrome P450eryF studied by lifetime FRET and pressure‐perturbation spectroscopy (2008) (0)
- Selective inhibition by chloramphenicol of pregnenolone-16. cap alpha. -carbonitrile-inducible rat liver cytochrome P-450 isozymes (1986) (0)
- Application of 3-Dimensional Homology Modeling of Cytochrome P450 2B1 for Interpretation of Site-Directed Mutagenesis Results. (1994) (0)
- Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene. (2013) (0)
- MECHANISM OF THE INACTIVATION OF RAT LIVER CYTOCHROME P-450 BY PARATHION (1980) (0)
- Crystal structure of a cytochrome P450 2A6 in complex with a monoterpene - sabinene. (2015) (0)
- STRUCTURE OF P450 2B4 F202W MUTANT (2016) (0)
- Using CYP3A4 NMR derived structural information to mitigate time‐dependent inhibition due to diltiazem metabolism (2019) (0)
- Crystal Structure of CYP2B6 (Y226H/K262R/I114V) in complex with myrtenyl bromide (2017) (0)
- Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole (2011) (0)
- Engineering of Human Cytochrome P450 2B6 for Enhanced Expression, Stability, and Functional Studies of the Wild‐Type and Genetic Variants (2008) (0)
- Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole (2010) (0)
- Role of Cytochrome b 5 in Modulating Peroxide-supported CYP 3 A 4 Activity : Evidence for a Conformational Transition and P 450 Heterogeneity (2005) (0)
- Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine (2012) (0)
- Ligand‐Induced Conformational Changes in Cytochrome P450 2B4: A Multi‐Technique Approach (2010) (0)
- Characterization of the P450 2B6 genetic variant K262R for temperature stability and drug binding (2008) (0)
- Crystal Structure of a Cytochrome P450 2b6 Genetic Variant in Complex With the Inhibitor 4-(4-Chlorophenyl)Imidazole at 2.0-Angstrom Resolution (2012) (0)
- Ligand‐induced conformational changes in cytochrome P450 3A4 detected by luminescence resonance energy transfer (LRET) (2012) (0)
- A high‐resolution crystal structure of ligand‐free cytochrome P450 2B4 (H226Y) in a closed conformation (2010) (0)
- Formation and fate of reactive intermediates of parathion. (1981) (0)
- Correction to The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4 (2012) (0)
- Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel (2013) (0)
- Structure of Cytochrome P450 2B4 with Bound 1-(4-cholorophenyl)imidazole (2007) (0)
- Using the Specialization Framework to Determine Degree of Dietary Specialization in a Herbivorous Woodrat (2015) (0)
- COOPERATIVITY MECHANISM IN CYTOCHROME P450 3A4 DEMONSTRATED BY FRET AND ABSORBANCE SPECTROSCOPY (2006) (0)
- Crystal Structure of cytochrome P450 2B4-H226Y in a closed conformation (2010) (0)
- Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene (2013) (0)
- Use of phenoxyaniline analogs to generate biochemical insights into polybrominated diphenyl ether interaction with CYP2B enzymes (2018) (0)
- Dual Ligand Complexes of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 with Amlodipine Reveal Substrate Access Channels into the Active Site (2012) (0)
- Crystal Structure of Cytochrome P450 2B37 from Desert Woodrat in complex with 4-(4-chlorophenyl)imidazole (2016) (0)
- Mechanisms of regulation of hormone- and substrate-dependent control of cytochrome P450 turnover (1992) (0)
- Kinetics of substrate binding to human Cytochrome P450 3A4: A study with Fluorol‐7GA, a fluorescent allosteric ligand (2010) (0)
- Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene (2016) (0)
- Ethanol metabolism in kupffer cells, cytochrome P4502E1 and enhanced TNFα release (1998) (0)
- STRUCTURE OF P450 2B4 F202W MUTANT (CYMAL-5) (2016) (0)
- Exploring enzyme conformational landscape with pressure‐perturbation: allosteric rearrangements in P450 3A4 revealed with FRET and SDSL‐EPR (769.16) (2014) (0)
- Dehydrogenation of the Indoline-Containing Drug, Indapamide, by CYP3A4: Correlation with in silico Predictions (2008) (0)
- Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog. (2018) (0)
- Functional Characterization of Cytochromes P450 2B from Woodrats (2012) (0)
- Novel Modifications of Job’s Method Applied to Determination of the Stoichiometry of Cytochrome P450 3A4 Interactions With Substrates (2006) (0)
- Expression of a mammalian PCB-metabolizing cytochrome P-450 in Nicotiana tabacum (1991) (0)
- Functional analysis of cytochrome P450 2B isoforms using ticlopidine as an active site probe (2012) (0)
- Structural importance of residue 334 in the stability of cytochromes P450 2B6 and 2B11 (2010) (0)
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