James Woodgett

Q: What Schools Are Affiliated With James Woodgett

James Woodgett is affiliated with the following schools: University of Toronto, Massachusetts General Hospital, Thomas Jefferson University, Duke University, Harvard University, University of Alabama, University of York, University of Dundee, Vanderbilt University

James Woodgett's AcademicInfluence.com Rankings

James Woodgett

Biology

#2740

World Rank

#4314

Historical Rank

Molecular Biology

#387

World Rank

#394

Historical Rank

Neuroscience

#526

World Rank

#546

Historical Rank

Biochemistry

#507

World Rank

#593

Historical Rank

biology Degrees

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Biology

Why Is James Woodgett Influential?

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According to Wikipedia, James Woodgett is a British-born biologist and the Principal Investigator of an active research laboratory at the Lunenfeld-Tanenbaum Research Institute, Sinai Health System , in Toronto, Ontario, Canada. He was the Koffler Director of Research at the Lunenfeld-Tanenbaum Research Institute from November 2005 to January 2021.

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James Woodgett's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The ground state of embryonic stem cell self-renewal (2008) (3252)
The stress-activated protein kinase subfamily of c-Jun kinases (1994) (2727)
GSK-3: tricks of the trade for a multi-tasking kinase (2003) (2082)
Phosphorylation of c-jun mediated by MAP kinases (1991) (1426)
Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells (1996) (1337)
Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation (2000) (1255)
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. (1998) (1144)
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (1998) (1124)
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun (1994) (1016)
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity (1991) (922)
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation (2005) (847)
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. (2004) (785)
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. (2000) (770)
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. (2000) (752)
Systematic Discovery of In Vivo Phosphorylation Networks (2007) (747)
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 (1994) (740)
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase (1992) (693)
The stress-activated protein kinase pathways (1999) (676)
PKB/AKT: functional insights from genetic models (2001) (628)
Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts (1999) (617)
Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation. (1993) (595)
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. (1994) (586)
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. (1991) (517)
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos (1995) (506)
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions (2007) (479)
Proteomic, Functional, and Domain-Based Analysis of In Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization (2004) (476)
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells (1994) (462)
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat (1996) (458)
Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. (1986) (450)
Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium (2004) (431)
Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy (2000) (422)
Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines (2007) (420)
Unravelling the activation mechanisms of protein kinase B/Akt (2003) (420)
Assessment of Social Interaction Behaviors (2011) (417)
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. (2006) (412)
Wingless inactivates glycogen synthase kinase‐3 via an intracellular signalling pathway which involves a protein kinase C. (1996) (410)
GSK-3: Functional Insights from Cell Biology and Animal Models (2011) (406)
Glycogen synthase kinase-3: functions in oncogenesis and development. (1992) (392)
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes. (1992) (390)
Glycogen synthase kinase-3: properties, functions, and regulation. (2001) (375)
GSK-3 is a master regulator of neural progenitor homeostasis (2009) (374)
Recent advances in the protein kinase B signaling pathway. (2005) (371)
Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo (2000) (370)
Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B (2002) (349)
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3 (1997) (339)
MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. (1996) (336)
Judging a Protein by More Than Its Name: GSK-3 (2001) (299)
Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression (2001) (299)
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. (2007) (298)
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes. (2013) (297)
Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. (2002) (285)
Glycogen synthase kinase-3--an overview of an over-achieving protein kinase. (2006) (281)
The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. (1994) (277)
DREAM Is a Critical Transcriptional Repressor for Pain Modulation (2002) (268)
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. (2007) (268)
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. (2004) (263)
The links between axin and carcinogenesis (2005) (254)
Tissue-Specific Role of Glycogen Synthase Kinase 3β in Glucose Homeostasis and Insulin Action (2008) (249)
Essential Roles for GSK-3s and GSK-3-Primed Substrates in Neurotrophin-Induced and Hippocampal Axon Growth (2006) (243)
Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. (1994) (241)
Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth (2003) (240)
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. (1996) (236)
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. (2008) (232)
Glycogen synthase kinase 3 regulates cell fate in dictyostelium (1995) (226)
Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase (1995) (226)
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex (1999) (225)
Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK) (1995) (208)
Multisite phosphorylation of glycogen synthase. Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5). (1984) (200)
Cross‐linking CD40 on B cells preferentially induces stress‐activated protein kinases rather than mitogen‐activated protein kinases. (1996) (198)
R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling* (2007) (196)
A molecular compendium of genes expressed in multiple myeloma. (2002) (191)
The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila (2000) (188)
GSK3 is a metabolic checkpoint regulator in B cells (2016) (187)
Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. (1993) (186)
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. (2006) (185)
Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway (2002) (184)
Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-Mesenchymal Transitions (2007) (180)
X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway* (2001) (174)
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini (1991) (174)
The active form of glycogen synthase kinase-3β is associated with granulovacuolar degeneration in neurons in Alzheimer's disease (2002) (172)
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice (2009) (170)
The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo (1986) (167)
Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword? (2004) (167)
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. (2009) (165)
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. (1999) (163)
Glycogen Synthase Kinase 3β Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1* (2000) (159)
When pathways collide: collaboration and connivance among signalling proteins in development (2010) (159)
CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly (2002) (158)
Protein kinase C phosphorylates pp60 src at a novel site (1985) (157)
Substrate specificity of a multifunctional calmodulin-dependent protein kinase. (1985) (156)
The GSK-3 family as therapeutic target for myocardial diseases. (2015) (154)
Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways. (2002) (153)
Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3 (2000) (151)
Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival* (2003) (149)
Glycogen Synthase Kinase 3: A Kinase for All Pathways? (2017) (145)
Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes (1997) (145)
Genetic analysis of protein kinase B (AKT) in Drosophila (1998) (139)
Modulation of cellular apoptotic potential: contributions to oncogenesis (1999) (137)
GSK-3β Controls Osteogenesis through Regulating Runx2 Activity (2007) (136)
Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development* (2009) (134)
Differential Cellular Phosphorylation of Neurofilament Heavy Side‐Arms by Glycogen Synthase Kinase‐3 and Cyclin‐Dependent Kinase‐5 (1996) (133)
The stress activated protein kinase pathway. (1996) (133)
IL-17 Receptor Signaling Inhibits C/EBPβ by Sequential Phosphorylation of the Regulatory 2 Domain (2009) (131)
The calmodulin-dependent glycogen synthase kinase from rabbit skeletal muscle. Purification, subunit structure and substrate specificity. (1983) (129)
GSK-3α is a central regulator of age-related pathologies in mice. (2013) (128)
Isolation and characterization of two distinct forms of protein kinase C. (1987) (127)
Serum and glucocorticoid‐regulated protein kinases: Variations on a theme (2006) (126)
Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium (2007) (124)
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1) (1999) (124)
Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. (1984) (122)
A common denominator linking glycogen metabolism, nuclear oncogenes and development. (1991) (122)
Cardiac Fibroblast Glycogen Synthase Kinase-3&bgr; Regulates Ventricular Remodeling and Dysfunction in Ischemic Heart (2014) (120)
Differential gene expression profiling of short and long term denervated muscle (2006) (119)
Mammalian Mitogen-activated Protein Kinase Pathways Are Regulated through Formation of Specific Kinase-Activator Complexes* (1996) (118)
cDNA cloning and properties of glycogen synthase kinase-3. (1991) (114)
Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. (1995) (113)
Regulation and functions of the glycogen synthase kinase-3 subfamily. (1994) (112)
Glycogen Synthase Kinase-3&bgr; Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo (2010) (109)
Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance (2008) (109)
Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Identification of the sites phosphorylated by casein kinase-I. (1982) (109)
Tau phosphorylation in transgenic mice expressing glycogen synthase kinase‐3β transgenes (1997) (108)
Opioid Effects on Mitogen‐activated Protein Kinase Signaling Cascades (1997) (107)
Glycogen synthase kinase-3 and cancer: good cop, bad cop? (2008) (104)
PHF‐tau from Alzheimer's brain comprises four species on SDS‐PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase‐3β (1994) (101)
GSK3β mediates muscle pathology in myotonic dystrophy. (2012) (101)
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome (2005) (101)
Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22 (2016) (100)
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice (2010) (100)
Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform of glycogen synthase kinase-3. (1992) (99)
β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation (2011) (98)
Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. (1992) (95)
GSK3: an in-Toll-erant protein kinase? (2005) (95)
mTOR regulates brain morphogenesis by mediating GSK3 signaling (2014) (95)
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes (2008) (93)
Genetic and pharmacological evidence for schizophrenia‐related Disc1 interaction with GSK‐3 (2011) (91)
Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation1 (2001) (89)
Phosphoinositide-Dependent Phosphorylation of PDK1 Regulates Nuclear Translocation (2005) (88)
Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB. (1999) (85)
Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders. (2003) (84)
Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival* (2010) (84)
Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. (2003) (83)
Immunological evidence for two physiological forms of protein kinase C (1987) (81)
Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity. (1999) (80)
Activation of mammalian DNA ligase I through phosphorylation by casein kinase II. (1992) (79)
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy. (2016) (77)
Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase (*) (1995) (76)
Recent advances in understanding the cellular roles of GSK-3 (2017) (75)
Glycogen synthase kinase-3 (GSK-3) is regulated during Dictyostelium development via the serpentine receptor cAR3. (1999) (75)
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. (2008) (75)
Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3 (2013) (73)
Glycogen Synthase Kinase-3β Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3* (2007) (71)
GSK-3α/β kinases and amyloid production in vivo (2011) (71)
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance. (2012) (71)
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases (2018) (70)
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 (2014) (69)
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. (2010) (69)
Regulation of the Protein Kinase Activity of ShaggyZeste-white3 by Components of the Wingless Pathway in Drosophila Cells and Embryos* (1999) (68)
Targeting GSK-3 family members in the heart: a very sharp double-edged sword. (2011) (68)
Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts (1999) (66)
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. (2008) (65)
Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation (2001) (64)
Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas (2008) (64)
Glycogen Synthase Kinase-3&agr; Limits Ischemic Injury, Cardiac Rupture, Post–Myocardial Infarction Remodeling and Death (2011) (64)
Role of the Phox Homology Domain and Phosphorylation in Activation of Serum and Glucocorticoid-regulated Kinase-3* (2006) (62)
Molecular stratification within triple-negative breast cancer subtypes (2019) (62)
Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement. (1995) (60)
Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells. (1993) (60)
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation (2012) (59)
Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? (2010) (59)
Osmotic Stimulation of the Na+/H+ Exchanger NHE1: Relationship to the Activation of Three MAPK Pathways (2001) (59)
Evidence that amiloride antagonises insulin‐stimulated protein phosphorylation by inhibiting protein kinase activity (1983) (58)
Cytosolic Alkalinization Increases Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase (SAPK/JNK) Activity and p38 Mitogen-activated Protein Kinase Activity by a Calcium-independent Mechanism* (1997) (58)
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. (2010) (58)
Lef1 Haploinsufficient Mice Display a Low Turnover and Low Bone Mass Phenotype in a Gender- and Age-Specific Manner (2009) (57)
Identification of a calmodulin‐dependent glycogen synthase kinase in rabbit skeletal muscle, distinct from phosphorylase kinase (1982) (55)
Protein kinases: Six degrees of separation? (2000) (53)
Phorbol ester-induced down-regulation of protein kinase C abolishes vasopressin-mediated responses in rat anterior pituitary cells. (1987) (53)
Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice (2012) (52)
Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product. (1992) (52)
Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site. (1992) (52)
Reconstitution of novel signalling cascades responding to cellular stresses. (1996) (51)
NF-κB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo (2005) (50)
Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. (2014) (50)
Stimulation of MAP kinase by v‐raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau (1995) (47)
Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. (2006) (47)
Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer (2018) (46)
Differential subcellular localisation of two isoforms of p70 S6 protein kinase. (1994) (46)
Glycogen Synthase Kinase 3β Is a Negative Regulator of Growth Factor-induced Activation of the c-Jun N-terminal Kinase* (2004) (46)
Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients. (2015) (46)
Alzheimer's disease: Mental plaque removal (2003) (44)
trking neurotrophic receptors (1991) (44)
Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO. (1991) (43)
CD4+ and CD8+ T Cell Survival Is Regulated Differentially by Protein Kinase Cθ, c-Rel, and Protein Kinase B1 (2007) (43)
Glycogen synthase kinase-3&bgr; heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results (2008) (42)
GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation* (2012) (42)
Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant (1997) (41)
Regulation of Drosophila tracheal system development by protein kinase B. (2001) (40)
Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells (1995) (39)
Comparison of calmodulin‐dependent glycogen synthase kinase from skeletal muscle and calmodulin‐dependent protein kinase‐II from brain (1984) (39)
Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor? (2009) (39)
Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation (2011) (38)
Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease (2014) (38)
Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression. (2011) (38)
Differential gene expression profile reveals deregulation of pregnancy specific β1 glycoprotein 9 early during colorectal carcinogenesis (2005) (38)
Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol (2010) (38)
Selective effects of CAPP1-calmodulin on its target proteins. (1985) (37)
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM (1997) (37)
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function (2019) (37)
REGULATION OF NUCLEAR TRANSCRIPTION FACTORS BY STRESS SIGNALS (1995) (37)
Phosphatidylinositol 3′ Kinase Signaling in Mammary Tumorigenesis (2004) (36)
ATP citrate-lyase and glycogen synthase kinase-3 beta in 3T3-L1 cells during differentiation into adipocytes. (1994) (35)
Protein Kinase C and its Role in Cell Growth (1987) (34)
Use of peptide substrates for affinity purification of protein-serine kinases. (1989) (34)
Chronic activation of protein kinase Bβ/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis (2005) (34)
CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases. (1996) (33)
A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product. (1993) (32)
Cardioprotective stress response in the human fetal heart. (2005) (32)
Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice (2011) (31)
Role of Phosphoinositide 3-Kinase &agr;, Protein Kinase C, and L-Type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility (2010) (30)
The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines. (1995) (30)
A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling (2019) (30)
Glycogen synthase kinase-3 ( GSK-3 ) is regulated during Dictyostelium development via the serpentine receptor cAR 3 (1998) (29)
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation. (2012) (29)
GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span. (2013) (29)
An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo (1998) (28)
Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway (2015) (27)
The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line. (2001) (27)
Erratum: A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases (S0092867418301156 (2018) 172(5) (1050–1062.e14) (S0092867418301156) (10.1016/j.cell.2018.01.038)) (2018) (26)
Regulation of jun/AP-1 oncoproteins by protein phosphorylation. (1993) (26)
Roles of glycogen synthase kinase-3 in signal transduction. (1993) (26)
The Stress‐activated Protein Kinases (1995) (26)
Isoform-specific requirement for GSK3α in sperm for male fertility† (2018) (26)
The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons (2012) (26)
Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant (1996) (25)
Fos and jun: two into one will go. (1990) (25)
Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine fibroblasts (2008) (24)
Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice. (2015) (24)
GSK-3 alpha/beta kinases and amyloid production in vivo (2011) (24)
Protein kinase functions (2000) (23)
Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin. (2016) (23)
A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition (2017) (22)
Clinical uses of microarrays in cancer research. (2008) (22)
Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload. (2019) (22)
Arabidopsis homologs of the shaggy and GSK-3 protein kinases: molecular cloning and functional expression in Escherichia coli (1994) (22)
Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology (2017) (22)
Emerging roles of GSK-3α in pathophysiology: Emphasis on cardio-metabolic disorders. (2019) (21)
Neurological Functions of the Masterswitch Protein Kinase – Gsk-3 (2012) (21)
A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells (2019) (21)
GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib (2020) (21)
Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation. (1994) (21)
PTEN--Coupling Tumor Suppression to Stem Cells? (2001) (21)
Early gene induction by growth factors. (1989) (20)
Correction of GSK3ß at young age prevents muscle pathology in mice with myotonic dystrophy type 1 (2017) (19)
Signals Controlling Un-Differentiated States in Embryonic Stem and Cancer Cells: Role of the Phosphatidylinositol 3′ Kinase Pathway (2014) (19)
Xanthatin triggers Chk1‐mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells (2017) (18)
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. (2004) (16)
Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps (2018) (16)
Modulating autoimmunity: pick your PI3 kinase (2005) (16)
Cardiac Fibroblast GSK-3 Regulates Ventricular Remodeling and Dysfunction in Ischemic Heart (2014) (15)
Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner (2013) (15)
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM. (1997) (14)
Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer (2004) (14)
Glycogen Synthase Kinase‐3: Properties, Functions, and Regulation (2001) (14)
Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods (2021) (13)
Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation (2017) (13)
Toronto Workshop on Late Recurrence in Estrogen Receptor–Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations (2019) (12)
Opposing regulation of B cell receptor‐induced activation of mitogen‐activated protein kinases by CD45 (2001) (12)
ERRATUM: Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos (1995) (12)
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases (2018) (12)
JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. (2003) (11)
Mitogen Activated Protein Kinases (2020) (11)
Single Unpurified Breast Tumor-Initiating Cells from Multiple Mouse Models Efficiently Elicit Tumors in Immune-Competent Hosts (2013) (11)
Exploring pluripotency with chemical genetics. (2009) (11)
Glycogen synthase kinase‐3β inhibits tubular regeneration in acute kidney injury by a FoxM1‐dependent mechanism (2020) (10)
Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide. (2008) (10)
Finding the stepping stones downstream of ras (1992) (9)
Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90 (2016) (9)
Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions (2019) (9)
Can a two-faced kinase be exploited for osteosarcoma? (2012) (9)
A kinase with Ku-dos (1993) (9)
Stem cells. PTEN--coupling tumor suppression to stem cells? (2001) (8)
Problems with Co-Funding in Canada (2005) (7)
Comparison of SARS-CoV-2 Indirect and Direct Detection Methods (2020) (7)
Multicenter international assessment of a SARS-CoV-2 RT-LAMP test for point of care clinical application (2022) (7)
Use of synthetic peptides mimicking phosphorylation sites for affinity purification of protein-serine kinases. (1991) (7)
Novel components of mammalian stress-activated protein kinase cascades. (1997) (7)
We must be open about our mistakes (2012) (7)
Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates. (1990) (6)
Nuclear onco-protein targets of signal transduction pathways. (1994) (6)
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. (1992) (5)
The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin (2013) (5)
Glycogen Synthase Kinase 3: An Introductory Synopsis (2006) (5)
Chapter 13 Mitogen-activated protein kinases and stress (2001) (5)
Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function (2019) (4)
Cardiomyocyte GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms (2021) (4)
Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice (2021) (4)
Powering the cell cycle (1991) (3)
NIH funding: Thousand-citation papers are outliers (2012) (3)
GSK-3b Controls Osteogenesis through Regulating Runx2 (2007) (3)
Glycogen Synthase Kinase-3 (2004) (3)
Cardiomyocyte‐GSK‐3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms (2021) (3)
GSK3 (cid:1) Mediates Renal Response to Vasopressin by Modulating Adenylate Cyclase Activity (2010) (3)
Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer (2021) (3)
Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice (2020) (2)
Regulation of protein kinase C by activators, Ca2+, and phosphorylation. (1987) (2)
PROTEIN PHOSPHORYLATION AND THE NEURAL AND HORMONAL CONTROL OF ENZYME ACTIVITY1 (1983) (2)
Phosphorylation of tau by glycogen synthase kinase-3 beta in vitro produces species with similar electrophoretic and immunogenic properties to PHF-tau from Alzheimer's disease brain. (1995) (2)
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart (2022) (2)
Glycogen Synthase Kinase-3 in Neurological Diseases (2012) (2)
Transgenic mice harbouring glycogen synthase kinase-3beta transgenes as a route for manipulating tau phosphorylation in vivo. (1995) (2)
Creating a home page. (1997) (2)
Faculty Opinions recommendation of Glycogen synthase kinase-3 inhibition promotes proliferation and neuronal differentiation of human-induced pluripotent stem cell-derived neural progenitors. (2012) (1)
Protein Kinases: Physiological Roles in Cell Signalling (2006) (1)
Advances in Brief Molecular Profiling of Non-Small Cell Lung Cancer and Correlation with Disease-free Survival 1 (2002) (1)
Who Actually Funds Cancer Research? (2019) (1)
Regulation of the Protein Kinase Activity of Shaggy by Components of the Wingless Pathway in Cells and Embryos (1999) (1)
GSK-3a/b kinases and amyloid production in vivo (2019) (1)
- GSK3: Glycogen synthase kinase-3 (vertebrates) (Factor FA, ATP-citrate lyase kinase) (1995) (1)
Faculty Opinions recommendation of Single cell profiling of potentiated phospho-protein networks in cancer cells. (2004) (1)
Protein Kinases: Physiological Roles (2001) (1)
Analysis of gene expression patterns in breast cancer by microarray technology (2001) (1)
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 (2014) (1)
Gender-specific control of peak bone mass by the Wnt pathway: Androgen signaling protects against lef1 haploinsufficiency-induced bone loss (2008) (1)
Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus (2022) (1)
GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson’s disease (2021) (1)
Phosphorylation of Tau in transiently transfected control and Raf transformed 3T3 cells (1994) (1)
Burning platforms: friending social media's role in #scicomm. (2014) (1)
Neurobiology. trking neurotrophic receptors. (1991) (1)
TNF-α and IL-1β activate p38 mitogen-activated and C-jun N-terminal kinase signaling cascades in myocytes, and interacts with free radicals (1999) (1)
Abstract P409: GSK-3β Deficiency In Cardiomyocyte Induces Cardiac Progenitor Cell Proliferation In The Ischemic Heart (2021) (0)
Abstract P335: Is GSK-3α a Regulator of Aging? (2011) (0)
Abstract 3470: Deletion of Glycogen Synthase Kinase-3{alpha} (GKS-3{alpha}) Causes a Glycogen Storage Cardiomyopathy (2008) (0)
Faculty Opinions recommendation of Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis. (2012) (0)
Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology (2018) (0)
Protein Kinase B , c-Rel , θ Differentially by Protein Kinase C T Cell Survival Is Regulated + and CD 8 + CD 4 (2007) (0)
Homeostasis and Promotes Inflammation Cells Perturbs Both T and B Cell Expression of Active Protein Kinase B in T (2001) (0)
O4-01-01: Analysis of the metabolism of amyloid precursor protein and of protein tau in mice with neuron-specific postnatal deficiency of Gsk3β (2008) (0)
STEM CELLS AND REGENERATION mTOR regulates brain morphogenesis by mediating GSK 3 signaling (2014) (0)
Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells. (2022) (0)
Molecular Mechanisms Underlying Pluripotency and Lineage Commitment – The Role of GSK-3 (2011) (0)
FO033PODOCYTE SPECIFIC GLYCOGEN SYNTHASE KINASE 3 IS CRITICAL FOR KIDNEY FUCTION IN DEVELOPMENT AND MATURITY (2015) (0)
A team of centre forwards (1998) (0)
the Regulation of Lymphocyte Homeostasis Signaling to Distinct Survival Pathways and B Couples Protein Kinase B/Akt κ NF- (2013) (0)
Basic research: bizarre but essential (2010) (0)
CHAPTER 83 – MAP Kinases (2003) (0)
Open Heart Surgery of PI-3 Kinase Signaling (2002) (0)
Abstract P1-07-24: Modeling breast cancer metastasis in the mouse via measurement of circulating tumor cells (2015) (0)
Global Approaches to Understanding Protein Kinase Functions (2015) (0)
Impact: Akin to quantifying dreams (2013) (0)
Path-ology: the cartography of life. The Regulation of Growth and Development--the Elucidation of Signal Pathways, the Fifth Annual Symposium on Biotechnology, sponsored by the Biological Council, London, UK, December 14-15, 1989. (1990) (0)
Signaling Via the T Cell Costimulatory Role of the Stress Kinase Pathway in (0)
Table of Contents (1996) (0)
Validation of a prognostic model to predict survival after non-small-cell lung cancer surgery (2010) (0)
P3-307 Glycogen synthase kinase-3beta and the p25 activator of cyclin-dependent kinase-5 decrease neuritogenesis and fast axoplasmic transport in differentiated PC12 cells (2006) (0)
Enabling the Next 25 Years of Cell Biology. (2016) (0)
A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling (2019) (0)
Faculty Opinions recommendation of Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. (2006) (0)
P-129 Gimap5 Is Required for GSK3ß Inhibition Controlling the Transcriptional Program Required for T Cell Proliferation/Differentiation While Maintaining Gut Homeostasis (2016) (0)
Abstract 1059: Glycogen Synthase Kinase 3-beta Regulates Cardiomyocyte Proliferation During Cardiac Development (2006) (0)
2029 The potential role of PKB as a modulator for heat sensitivity in MCF-7 cells (1999) (0)
Molecular and Cellular Approaches to the Control of Proliferation and Differentiation: edited by G.S. Stein and J.B. Lian Academic Press, 1991. $125.00 (xiv + 426 pages) ISBN 0 12 664 745 3 (1992) (0)
Abstract 199: Targeted Deletion of Glycogen Synthase Kinase-3{alpha}(GSK-3{alpha}) vs. GSK-3{beta} identifies unique isoform-specific effects on development and hypertrophy (2007) (0)
SAPKs A MAP kinase subfamily that transduces stress and TNF-alpha signals to c-Jun (1994) (0)
Cell Survival Signaling through Phosphoinositide 3‐kinase and Protein Kinase B (2008) (0)
F1000Prime recommendation of Encoding and decoding cellular information through signaling dynamics. (2017) (0)
The roles of glycogen synthase kinase-3 genes in liver functions (2017) (0)
GSK-3 (cid:68) Limits Ischemic Injury, Cardiac Rupture, Post- Myocardial Infarction Remodeling and Death (2011) (0)
Interactomes of Glycogen Synthase Kinase-3 Isoforms (2023) (0)
406 The effects of stress-activated protein (SAP) kinases (JNKs) on cellular Tau and APP metabolism studied in transfected mammalian cells (1996) (0)
Renal Collecting Duct Specific GSK 3 alpha Regulates Cellular Distribution and Lithium‐Induced NDI (2012) (0)
Immunological Evidence forTwoPhysiological Formsof (1987) (0)
P.6.002 Behavioral phenotyping of GSK-3 beta knockout heterozygote mice (2003) (0)
GSK-3b in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1– dependent mechanism (2018) (0)
Correction of GSK3 b at young age prevents muscle pathology in mice with myotonic dystrophy type 1 (2018) (0)
Renal Collecting Duct GSK3ß Deletion Affects Response To AVP By Reducing Adenylate Cyclase Activity (2009) (0)
Generation and characterization of drug-inducible forebrain-specific mice mutant for both glycogen synthase kinase-3 alpha and beta genes (2011) (0)
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function (2019) (0)
Abstract LB-93: The role of GSK-3 in mammary gland development and oncogenesis (2011) (0)
Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods (2021) (0)
Micromanaging ideas risks impeding flow of potential benefits (2008) (0)
Development of a drug repressible β-catenin mutant mouse to examine effect of activated β-catenin signaling on long-term maintenance of mammary tumor growth (2019) (0)
Jim Woodgett (2007) (0)
Abstract A29: Generation of a novel transgenic mouse model with regulatable β-catenin expression to examine importance of activated β-catenin signaling to long-term maintenance of mammary tumor growth (2018) (0)
Q&A: Jim Woodgett. (2007) (0)
Abstract 13350: Cardiac-specific Deletion of GSK-3α and GSK-3β Leads to Fatal Dilated Cardiomyopathy With Mitotic Catastrophe (2014) (0)
How to Become a Control Freak (2014) (0)
What is the "gold" standard to indicate a gene inclusively ie including regulatory, promoter or other elements at both ends of the transcribable DNA segment? (2003) (0)
Fasting Blood Glucose Concentration at 6 and 8 wk of Age in Either WT, Gsk-3β+/−, Irs2−/−, or Gsk-3β+/−Irs2−/− Mice (2008) (0)
There's more to lithium than Nirvana (2013) (0)
S1639 A Crucial Role for Glycogen Synthase Kinase-3beta in Colonic Epithelial Cells During Experimental Murine Colitis (2009) (0)
IMPORTANCE OF HYDROPHOBIC MOTIF INTERACTIONS IN THE ACTIVATION OF SGK 3 (2005) (0)
Telling the players without a scorecard. Gene Cascades and Second Messengers in Cancer Sponsored by the Research Institute of Molecular Pathology, Vienna, Austria, May 20-22, 1989. (1989) (0)
How to continually make the case for fundamental science - from the perspective of a protein kinase. (2019) (0)
Behavioral phenotyping of GSK-3beta knockout mice (2003) (0)
Migration of Human Cardiac Progenitor Cells in the Infarcted Mouse Heart (0)
Regulation of thymocyte β-selection, development and positive selection by glycogen synthase kinase-3 (2019) (0)
Characterization of the Role of CXCL 10 and CXCR 3 in Breast Cancer (2009) (0)
University of Birmingham A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling (2019) (0)

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