James A. Wells

Q: What Schools Are Affiliated With James A. Wells

James A. Wells is affiliated with the following schools: University of California, Berkeley, University of Toronto, University of California, San Francisco

James A. Wells's AcademicInfluence.com Rankings

James A. Wells

Chemistry

#1092

World Rank

#1737

Historical Rank

#441

USA Rank

Organic Chemistry

#138

World Rank

#178

Historical Rank

#53

USA Rank

chemistry Degrees

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Chemistry

James A. Wells's Degrees

PhD Pharmaceutical Chemistry University of California, San Francisco
Bachelors Chemistry University of California, Berkeley

Why Is James A. Wells Influential?

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According to Wikipedia, James Allen Wells is a Professor of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology at the University of California, San Francisco and a member of the National Academy of Sciences. He received his B.A. degrees in biochemistry and psychology from University of California, Berkeley in 1973 and a PhD in biochemistry from Washington State University with Ralph Yount, PhD in 1979. He completed his postdoctoral studies at Stanford University School of Medicine with George Stark in 1982. He is a pioneer in protein engineering, phage display, fragment-based lead discovery, cellular apoptosis, and the cell surface proteome.

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James A. Wells's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
A hot spot of binding energy in a hormone-receptor interface (1995) (1851)
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces (2007) (1744)
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream (2004) (1460)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions (2013) (1455)
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. (1989) (1278)
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. (1991) (830)
Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. (2014) (769)
Rational design of potent antagonists to the human growth hormone receptor. (1992) (623)
Convergent solutions to binding at a protein-protein interface. (2000) (604)
Additivity of mutational effects in proteins. (1990) (590)
Dissecting the catalytic triad of a serine protease (1988) (544)
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. (2014) (522)
Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor (1997) (498)
Comparison of a structural and a functional epitope. (1993) (488)
Caspases and their substrates (2017) (453)
Sexually Dimorphic Neurons in the Ventromedial Hypothalamus Govern Mating in Both Sexes and Aggression in Males (2013) (441)
Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. (1997) (436)
Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini (2008) (417)
Phage display for selection of novel binding peptides. (2000) (407)
Binding in the growth hormone receptor complex. (1996) (406)
Site-directed ligand discovery. (2000) (374)
Hormone phage: An enrichment method for variant proteins with altered binding properties (1990) (338)
Binding of small molecules to an adaptive protein–protein interface (2003) (332)
Tethering: fragment-based drug discovery. (2004) (328)
Systematic mutational analyses of protein-protein interfaces. (1991) (328)
Cloning, sequencing, and secretion of Bacillus amyloliquefaciens subtilisin in Bacillus subtilis. (1983) (325)
Substrate phage: selection of protease substrates by monovalent phage display. (1993) (323)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis. (1989) (299)
Selecting high-affinity binding proteins by monovalent phage display. (1991) (298)
Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation. (1985) (292)
Hematopoietic receptor complexes. (1996) (283)
Caspase substrates and cellular remodeling. (2011) (283)
Searching for new allosteric sites in enzymes. (2004) (282)
Requirements for Binding and Signaling of the Kinase Domain Receptor for Vascular Endothelial Growth Factor* (1998) (278)
A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. (1991) (271)
Zinc mediation of the binding of human growth hormone to the human prolactin receptor. (1990) (269)
Minimizing a binding domain from protein A. (1996) (257)
Redox-based reagents for chemoselective methionine bioconjugation (2017) (255)
Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. (1998) (254)
Long-acting Growth Hormones Produced by Conjugation with Polyethylene Glycol* (1996) (254)
Subtilisin--an enzyme designed to be engineered. (1988) (242)
Discovery of an allosteric site in the caspases. (2004) (237)
Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites. (1985) (237)
A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues. (1994) (236)
In vitro selection from protein and peptide libraries. (1994) (228)
Dimerization of human growth hormone by zinc. (1991) (225)
Pharmaceutical preformulation : the physicochemical properties of drug substances (1988) (220)
Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library. (1997) (218)
High resolution functional analysis of antibody-antigen interactions. (1992) (212)
In vitro selection of zinc fingers with altered DNA-binding specificity. (1994) (212)
Affinity maturation of human growth hormone by monovalent phage display. (1993) (212)
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial (2018) (197)
In vivo formation and stability of engineered disulfide bonds in subtilisin. (1986) (195)
Probing Steric and Hydrophobic Effects on Enzyme-Substrate Interactions by Protein Engineering (1986) (193)
Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution. (1991) (192)
Rational design of receptor-specific variants of human growth hormone. (1991) (191)
Engineering enzyme specificity by "substrate-assisted catalysis". (1987) (185)
Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease (2010) (184)
Turning enzymes ON with small molecules. (2010) (182)
Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. (1998) (181)
Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein (2016) (181)
Designing substrate specificity by protein engineering of electrostatic interactions. (1987) (168)
Structural plasticity in a remodeled protein-protein interface. (1997) (168)
Small-Molecule Activators of a Proenzyme (2009) (161)
MRC BHFHeart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience (1999) (156)
Inflammatory Stimuli Regulate Caspase Substrate Profiles* (2010) (153)
A common allosteric site and mechanism in caspases (2006) (151)
Structural mimicry of a native protein by a minimized binding domain. (1997) (146)
Subtiligase: a tool for semisynthesis of proteins. (1994) (145)
Mechanism-based design of prolactin receptor antagonists. (1993) (142)
Prolactin Receptor Antagonists That Inhibit the Growth of Breast Cancer Cell Lines (*) (1995) (140)
The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain. (1990) (139)
Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial (2020) (138)
Hot-spot mimicry of a cytokine receptor by a small molecule (2006) (138)
Secretion and autoproteolytic maturation of subtilisin. (1986) (135)
CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. (2016) (134)
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of alzheimer's amyloid β‐protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): Engineering of inhibitors with altered specificities (1997) (131)
Turning a protein kinase on or off from a single allosteric site via disulfide trapping (2011) (126)
Protein engineering of disulfide bonds in subtilisin BPN'. (1989) (125)
Direct activation of the apoptosis machinery as a mechanism to target cancer cells (2003) (124)
High copy display of large proteins on phage for functional selections. (2000) (122)
Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor. (1992) (119)
Minimization of a Polypeptide Hormone (1995) (117)
The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells* (2012) (117)
Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland. (1993) (116)
Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering. (1987) (113)
The molecular basis for growth hormone-receptor interactions. (1993) (112)
Global kinetic analysis of proteolysis via quantitative targeted proteomics (2012) (111)
Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. (1994) (110)
Sampling the N-terminal proteome of human blood (2010) (109)
Selection for improved subtiligases by phage display. (1999) (108)
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 (2021) (103)
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 (2020) (102)
Engineering subtilisin BPN′ for site‐specific proteolysis (1989) (101)
Structure and function of human growth hormone: implications for the hematopoietins. (1993) (100)
Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity. (1999) (98)
Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. (2013) (97)
Potent small-molecule binding to a dynamic hot spot on IL-2. (2003) (96)
Engineering human prolactin to bind to the human growth hormone receptor. (1990) (94)
Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen. (1991) (91)
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes (2004) (91)
A survey of furin substrate specificity using substrate phage display (1994) (91)
A reactivity-based probe of the intracellular labile ferrous iron pool (2016) (88)
Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity (2016) (87)
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 (2020) (87)
Two-state selection of conformation-specific antibodies (2009) (86)
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles (2016) (85)
An allosteric circuit in caspase-1. (2008) (84)
Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. (1997) (84)
Higgs boson potential at colliders: Status and perspectives (2019) (80)
Structural and functional basis for hormone binding and receptor oligomerization. (1994) (80)
Dissecting the energetics of an antibody‐antigen interface by alanine shaving and molecular grafting (1994) (76)
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering (2018) (73)
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay (2021) (73)
Wnt11/5a Complex Formation Caused by Tyrosine Sulfation Increases Canonical Signaling Activity (2009) (72)
ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens (2020) (71)
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. (2005) (71)
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. (2011) (71)
Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure. (1987) (70)
Methods for the proteomic identification of protease substrates. (2009) (70)
Ordering a dynamic protein via a small-molecule stabilizer. (2013) (68)
Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface. (1996) (68)
The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis. (1990) (68)
Functional interaction among catalytic residues in subtilisin BPN′ (1990) (67)
Production of an atrial natriuretic peptide variant that is specific for type A receptor. (1994) (67)
Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells (2007) (66)
Engineering peptide ligase specificity by proteomic identification of ligation sites (2017) (64)
Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis (2012) (64)
Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast * (2017) (64)
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 (2020) (62)
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1 (2014) (62)
Global cellular response to chemotherapy-induced apoptosis (2013) (62)
Incorporation of a stabilizing Ca(2+)-binding loop into subtilisin BPN'. (1992) (61)
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection (2021) (61)
Designing subtilisin BPN' to cleave substrates containing dibasic residues. (1995) (60)
Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics. (2017) (59)
Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis (2012) (58)
Nature-inspired design of motif-specific antibody scaffolds (2013) (57)
Prediction of protease substrates using sequence and structure features (2010) (57)
Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN'. (1991) (57)
ENZYMATIC CYCLIZATION OF LINEAR PEPTIDE ESTERS USING SUBTILIGASE (1995) (57)
Binding Interaction of the Heregulinβ egf Domain with ErbB3 and ErbB4 Receptors Assessed by Alanine Scanning Mutagenesis* (1998) (56)
Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins (2018) (56)
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation (2013) (56)
Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates. (1996) (55)
Rapid evolution of peptide and protein binding properties in vitro (1992) (55)
Subtiligase-Catalyzed Peptide Ligation. (2020) (54)
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues (2016) (53)
Probing the importance of second sphere residues in an esterolytic antibody by phage display. (1998) (53)
Monovalent phage display: A method for selecting variant proteins from random libraries (1991) (50)
Tags for labeling protein N-termini with subtiligase for proteomics. (2008) (48)
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes (2019) (47)
Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding (2020) (47)
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay (2021) (47)
Unraveling the mechanism of cell death induced by chemical fibrils (2014) (46)
Identification of molecular markers that are expressed in discrete anterior–posterior domains of the endoderm from the gastrula stage to mid‐gestation (2007) (46)
Fibrils Colocalize Caspase-3 with Procaspase-3 to Foster Maturation* (2012) (45)
Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity (2020) (45)
Dissecting an Allosteric Switch in Caspase-7 Using Chemical and Mutational Probes* (2009) (45)
Synthesis of proteins by subtiligase. (1997) (44)
Enzyme-catalyzed expressed protein ligation (2016) (43)
Human Antibody-Based Chemically Induced Dimerizers for Cell Therapeutic Applications (2017) (42)
Selection of Heregulin Variants Having Higher Affinity for the ErbB3 Receptor by Monovalent Phage Display* (1998) (42)
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies (2018) (41)
Will any dimer do? (1998) (41)
Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. (2017) (40)
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection (2020) (39)
Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling (2014) (39)
Engineering a light-activated caspase-3 for precise ablation of neurons in vivo (2017) (39)
Site-specific Disulfide Capture of Agonist and Antagonist Peptides on the C5a Receptor* (2005) (38)
Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome (2018) (38)
The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins. (2018) (38)
An improved single-chain Fab platform for efficient display and recombinant expression. (2015) (37)
Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases. (2019) (35)
Apo cytochrome c inhibits caspases by preventing apoptosome formation. (2004) (35)
The stoichiometry of growth hormone-binding protein complexes in human plasma: comparison with cell surface receptors. (1994) (34)
Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes research (2003) (33)
Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. (2016) (33)
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 (2020) (33)
Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3* (2013) (32)
The influence of granulating fluids upon granule and tablet properties: the role of secondary binding (1983) (32)
Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades (2017) (31)
FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. (2014) (30)
A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models (2016) (28)
Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. (2014) (28)
Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation (2019) (28)
An improved method for purifying 2',5'-oligoadenylate synthetases. (1984) (28)
Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis* (2011) (26)
The importance of a distal hydrogen bonding group in stabilizing the transition state in subtilisin BPN'. (1991) (26)
Minimized proteins. (1997) (26)
Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase. (2016) (26)
A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin. (1994) (24)
Mutational analysis of the major coat protein of M13 identifies residues that control protein display (2008) (24)
Turning on caspases with genetics and small molecules. (2014) (24)
Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. (2015) (23)
Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance (2021) (23)
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 (2021) (22)
Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface (2016) (21)
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries (2020) (21)
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. (2020) (20)
Solvent Isotope Effects in H2O−D2O Mixtures (Proton Inventories) on Serine-Protease-Catalyzed Hydrolysis Reactions. Influence of Oxyanion Hole Interactions and Medium Effects (1996) (19)
Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer (2020) (18)
Mapping proteolytic neo-N termini at the surface of living cells (2020) (18)
Malonate-assisted purification of human caspases. (2005) (18)
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators (2018) (17)
Structure from function: screening structural models with functional data. (1994) (17)
Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. (2018) (17)
Identification of Specific Tethered Inhibitors for Caspase‐5 (2012) (17)
Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2 (2021) (16)
A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding (2020) (16)
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis (2019) (15)
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 (2021) (13)
Fmoc-based synthesis of glycolate ester peptides for the assembly of de novo designed multimeric proteins using subtiligase (1996) (13)
Structural and Functional Epitopes in the Growth Hormone Receptor Complex (1995) (13)
Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration (2019) (12)
Molecules that modulate Apaf‐1 activity (2011) (12)
A Split-Abl Kinase for Direct Activation in Cells. (2017) (12)
A small molecule inhibitor of Caspase 1 (2011) (12)
Structure and function of a lignostilbene-α,β-dioxygenase orthologue from Pseudomonas brassicacearum (2018) (11)
Redox priming promotes Aurora A activation during mitosis (2020) (11)
Molecules That Modulate Apaf-1 Activity (2011) (10)
Engineering an interfacial zinc site to increase hormone-receptor affinity. (1994) (9)
Generated surface area measurement of disintegrating tablets (1977) (9)
Thrombin generation in patients undergoing carotid endarterectomy: implications in acute vessel wall closure and antithrombotic therapy. (1994) (9)
Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. (2018) (9)
Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins. (2022) (8)
Synthesis of Proteins by Subtiligase (1998) (8)
Split enzymes: Design principles and strategy. (2020) (7)
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance (2022) (7)
N‐Terminal Modification of Proteins with Subtiligase Specificity Variants (2020) (7)
On the evolution of specificity and catalysis in subtilisin. (1987) (7)
Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling (2015) (7)
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy (2021) (6)
Drug discovery at signaling interfaces. (2003) (6)
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers (2022) (6)
Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling* (2019) (6)
Immunodominant structures of human growth hormone identified by homolog-scanning mutagenesis. (1992) (6)
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike (2020) (6)
NCI Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. (2020) (6)
New Tricks for an Old Dimer (2014) (6)
Importance of conformational variability in protein engineering of subtilisin (1987) (5)
Facile synthesis of cyclic peptides containing di-, tri-, tetra-, and pentasulfides (1998) (5)
Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems (2022) (4)
Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction (2021) (4)
Caspase-4 and Caspase-5 (2013) (4)
Computational approach to site‐directed ligand discovery (2007) (4)
Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations (2019) (4)
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice. (2023) (4)
Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture. (2021) (4)
From big molecules to smaller ones (1999) (3)
Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. (2020) (3)
CUB domain containing protein 1 (CDCP1) is a target for radioligand therapy in castration resistant prostate cancer including PSMA null disease. (2022) (3)
Site‐Directed Fragment Discovery for Allostery (2016) (3)
Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression (2022) (3)
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins (2022) (3)
Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions (2022) (3)
Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules. (2021) (3)
Targeting phosphotyrosine in native proteins with conditional, bi-specific antibody traps. (2020) (3)
Activation of the Human Growth Hormone Receptor: Structure and Function of the Ligand-Receptor Complex (2000) (3)
Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance (2021) (3)
Next generation therapeutics. (2013) (3)
Warren L. DeLano 21 June 1972–3 November 2009 (2009) (2)
Solvent isotope effects on a hydrolysis reaction catalysed by subtilisin and its N155G mutant. Failure of the proton inventory method to report hydrogen-bonding interactions in the oxyanion hole (1995) (2)
Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells (2022) (2)
Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2 (2021) (2)
Switchable assembly and function of antibody complexes in vivo using a small molecule (2022) (2)
Labeling of Peptide Fragmented Mass Spectra in Proteomic Studies Exact Quantification of Complex Protein Mixtures Using MeCAT—Metal Coded Tagging (2009) (2)
Engineering and design. Recent adventures in molecular design. (1998) (2)
Solvent Isotope Effects in H2O−D2O Mixtures (Proton Inventories) on Serine-Protease-Catalyzed Hydrolysis Reactions. Influence of Oxyanion Hole Interactions and Medium Effects J. Am. Chem. Soc. 1996, 118, 8802−8807 (1997) (2)
Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to Nutrients (2022) (2)
433 Functional Enteric Nervous System in Human Small Intestine Derived From Pluripotent Stem Cells (2016) (2)
National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions (2020) (2)
Title Global Analysis of Cellular Proteolysis by Selective Enzymatic Labeling of Protein N-Termini Permalink (2014) (1)
Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancer (2021) (1)
Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase (2022) (1)
Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. (2014) (1)
Regulated Cell Death (2021) (1)
New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering (2017) (1)
Multi-omics analysis of AML cells treated with azacitidine reveals highly variable cell surface proteome remodeling (2018) (1)
Organoids as tools for fundamental discovery and translation—a Keystone Symposia report (2022) (1)
CRYSTAL STRUCTURE OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE (2000) (1)
Structure of SP4160 Bound to IL-2 V69A (2005) (1)
Rational design ofreceptor-specifi (1991) (1)
Anti-VEGF antibody (1998) (1)
Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody That Targets Two Distinct Epitopes on αv Integrins. (2021) (1)
FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2 (2000) (1)
CHEMICAL BIOLOGY: Redox‐based reagents for chemoselective methionine bioconjugation (2017) (1)
Activation of the Human Growth Hormone Receptor (2000) (1)
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas (2022) (1)
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation (2022) (1)
Understanding endoderm development: More than just a series of tubes (2011) (1)
Using Split Luminescent Biosensors for SARS‐CoV‐2 Antibody Detection in Serum, Plasma, and Blood Samples (2022) (1)
Inflammatory Stimuli Regulate Caspase Substrate Profiles* □ S (2010) (1)
Noncoding deletions reveal a gene that is critical for intestinal function (2019) (1)
CLONING AND SEQUENCING OF A REGION CONTROLLING EFFICIENT EXPRESSION OF SUBTILISIN FROM BACILLUS AMYLOLIQUEFACIENS1 (1984) (1)
Building additional complexity to in vitro-derived intestinal tissues (2013) (1)
Engineering Antibodies Targeting p16 MHC-Peptide Complexes. (2022) (1)
Crystal structure of active caspase-2 bound with Ac-ADVAD-CHO (2011) (1)
Regulated cell death part A: apoptotic mechanisms. Preface. (2014) (1)
Expressed Protein Ligation using subtiligase (2016) (1)
SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product (2017) (1)
Nonsense mutation in the novel PERCC1 gene as a genetic cause of congenital diarrhea and enteropathy. (2022) (1)
Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid (2002) (0)
pharmaceutical salts of amlodipine improved and pharmaceutical compositions containing them (1987) (0)
pharmaceutically acceptable salts of amlodipine, improved (1987) (0)
Foerfarande Foer framstaellning of terapeutiskt anvaendbart of besylatsalt, amlodipine. (1987) (0)
In preprints: humans, the new model organism. (2022) (0)
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps (2023) (0)
Improvement in pharmaceutically usable salt (1987) (0)
Probing and controlling cellular remodeling enzymes (2010) (0)
Pharmaceutical advantageous salt of amlodipine and pharmaceutical compositions containing this (1987) (0)
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation (2022) (0)
Pharmaceutisk fordelagtigt salt af amlodipin og farmaceutiske praeparater indeholdende dette (1987) (0)
Site‐directed Small Molecule Discovery for Adaptive and Allosteric Sites (2006) (0)
The benzenesulfonate salt of amlodipine and pharmaceutical compositions containing this (1987) (0)
Process for the preparation of amlodipine besylate with. (1987) (0)
Activity-based Proteomics: Applications for Enzyme and Inhibitor Discovery Global Profiling of Proteolytic Cleavage Sites in Apoptosis (2009) (0)
Enzyme Catalyzed Expressed Protein Ligation (2016) (0)
Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial. (2023) (0)
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps (2022) (0)
A general approach to discover conformational epitope-directed binders for selective inhibition of protein proteolytic activation (2022) (0)
Pharmaceutical Technology: Controlled Drug Release Vol 2 : Controlled Drug Release Vol 2 (2005) (0)
Engineered Caspases with Altered Specificities Enable Identification of Exosites (2016) (0)
American Mathematical Society Edited by with the Cooperation of Index to Volume 15 [december Cohomology of Groups in Arbitrary Categories (0)
A renaissance for developmental biology driven by new in vitro platforms. (2022) (0)
Theranostic targeting of CUB domain containing protein 1 (CDCP1) in multiple subtypes of bladder cancer. (2023) (0)
Transplanted human intestinal organoids: A resource for modeling human intestinal development. (2023) (0)
Secreted HLA Fc-Fusion Profiles Immunopeptidome in Hypoxic PDAC and Cellular Senescence (2023) (0)
Besylate de l'amlodipine (1987) (0)
Process for obtaining benzolsulphonate salt of 3-ethyl-5-methyl-2-(2-aminoetoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl pyridin-3,5-dicarboxylate (1987) (0)
Foerbaettringar at godkaennbara pharmaceutically salts. (1987) (0)
Sox17 and Sox4 Differentially Regulate (cid:2) -Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells (cid:1) (2007) (0)
Summary report of Les Houches "Physics at TeV Colliders 2003" Beyond the Standard Model Working Group: Summary Report (2004) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000396a (2018) (0)
Table 1, Investigation of SAR around aryl ring (2011) (0)
CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer (2021) (0)
Crystal structure of caspase-7 DEVE peptide complex (2016) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL (2000) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000141a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000194a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000847b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000295a (2018) (0)
[Table, Identification of lead]. (2011) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000603b (2018) (0)
PDK1 mutant bound to allosteric disulfide fragment activator JS30 (2011) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000515a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000449a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000531a (2018) (0)
Mechanically Induced Enterogenesis of Human Intestinal Organoids in vivo (2017) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000555a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000595a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000811b (2018) (0)
Identification and design of binding determinants in proteins. (1990) (0)
Multiconformer model of apo WT PTP1B with glycerol at 240 K (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000272b (2018) (0)
32 Cytokine-STAT5 Signaling Controls Intestinal Stem Cell Activation to Suppress Clostridium Difficile - Induced Gut Inflammation (2016) (0)
Detection of proteolytic signatures for Parkinson's disease (2016) (0)
Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000123a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000955b (2018) (0)
Crystal Structure of Apo Caspase2 (2011) (0)
Variants of human growth hormone (1996) (0)
Correction: Global cellular response to chemotherapy-induced apoptosis (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000539a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000324a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000211a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000611a (2018) (0)
Table 2, IC50 values for selected compounds versus caspase panel (2011) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000278a (2018) (0)
Title Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD 8 Ligase Permalink (2016) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000675b (2018) (0)
Probing and Designing Growth Hormone-Receptor Interactions (1995) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000216b (2018) (0)
Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C (2013) (0)
Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000608a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000752b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000644b (2018) (0)
Crystal structure of human caspase-1 (Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) (2006) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000240a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000628a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000509a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA001440b (2018) (0)
Structure of phosphoserine (pSAb) scaffold bound to pSer peptide (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000683b (2018) (0)
Abstract 1996: Surface proteomics of KRASG12V transfected MCF10A cells reveals molecular phenotype of a model cell line expressing oncogenic KRAS (2015) (0)
A process for the mutagenesis of DNA. (1984) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000269a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000074a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000398a (2018) (0)
Variants of vascular endothelial cell growth factor, as well as applications of these processes for the preparation thereof (1996) (0)
Human procaspase-3 bound to Ac-DEVD-CMK (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000475a (2018) (0)
Mapping Binding Interfaces and Allosteric Changes in the SARS-Cov-2 Spike Protein using Hydrogen/Deuterium Exchange Mass Spectrometry (2021) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000814b (2018) (0)
Scheme 1, Conditions and reagents (2011) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000275a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000632a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000187a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000505a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000281b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000708a (2018) (0)
Abstract SY08-02: Markers of caspase activation in cells and serum (2011) (0)
Table of Contents (1994) (0)
Hedgehog Signaling Regulates PDL-1 Expression in Gastric Cancer Cells to Induce Tumor Proliferation (2017) (0)
Wnt11/Wnt5a interaction increases canonical Wnt signaling activity (2009) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000140a (2018) (0)
Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-L-phenylalanine methyl ester (2002) (0)
Discovering and Manipulating Protein Conformational Heterogeneity and Function (2014) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000207a (2018) (0)
Container containing antibodies directed against VEGF (1998) (0)
Selection of improved peptide ligases by yeast surface display (2012) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000953b (2018) (0)
Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton (2018) (0)
Crystal Structure of K-Ras WT, GDP-bound (2013) (0)
Cell-surface tethered promiscuous biotinylators enable small-scale surface proteomics of human exosomes (2021) (0)
Mutants of non-human carbonyl hydrolase DNA sequences and vectors encoding them and hosts transformed with such vectors. (1987) (0)
Normally sporulerence Bacillus strain with no ability to secrete subtilisin or neutral protease and process for the production of proteins therewith (1993) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_PKTTA024495b (2018) (0)
Engineering and design. (1991) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000435a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000639a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000323a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000004a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000280c (2018) (0)
Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras. (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000242a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOZE000092b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000149a (2018) (0)
Abstract SY11-03: Turning enzymes on with small molecules (2010) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOCR000171b (2018) (0)
Variants of the growth factor of vascular endothelial cells, their use and methods for their production (1996) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000601a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000713b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000294a (2018) (0)
Crystal structure of human caspase-1 (Arg286->Ala, Glu390->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) (2006) (0)
Procaryotic carbonyl hydrolases, their preparation and manipulation by recombinant techniques, and their use in detergents (1984) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000069a (2018) (0)
Mutant of a non-human carbonyl hydrolase, for this coding DNA sequences and vectors and hosts transformed by these vectors. (1987) (0)
Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide (2013) (0)
Crystal structure of PDK1 in complex with ATP and PIFtide (2014) (0)
Molecular Endocrinology of Human Growth Hormone (1994) (0)
Multiconformer model of apo WT PTP1B with glycerol at 100 K (ALTERNATIVE REFINEMENT OF PDB 1SUG showing conformational heterogeneity) (2018) (0)
Subtilisin a model for protease engineering and secretion (1986) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000574a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000465a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA001247b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000127a (2018) (0)
Crystal Structure of H-Ras G12C, GDP-bound (2013) (0)
Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2 (2004) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000072a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000847b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000487a (2018) (0)
Crystal Structure of small molecule acrylamide 11 covalently bound to K-Ras G12C (2013) (0)
Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000650a (2018) (0)
Ligand antagonists for breast cancer management. (1994) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000144a (2018) (0)
Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K (2018) (0)
A functional mammalian display screen identifies rare antibodies that stimulate NK cell–mediated cytotoxicity (2021) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000114a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000270a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000484a (2018) (0)
Preparation orale utilisable chez les humains (1978) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-722 (2000) (0)
Caspase-2 bound to one copy of Ac-DVAD-CHO (2011) (0)
Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound (2013) (0)
Figure 1, Aqueous stability of prodrugs VX-765 (1)(♦) and NCGC-00185682 (3)(X) and drugs VRT-043198 (2b)(▴), NCGC-00183434/CID-44620939/ML132 (4)(■) and NCGC-00183681 (16)(●) at neutral (pH 7 - black), acidic (pH 2 - red), and basic (pH 8 - blue) conditions (2011) (0)
Multiconformer model of WT PTP1B with BB3 at 273 K (2018) (0)
Multiconformer model of apo K197C PTP1B at 100 K (2018) (0)
Figure 4, Molecular model (ribbon and space filling) of NCGC-00183434/CID-44620939/ML132 (4) bound to caspase 1 (2011) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000157a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000523a (2018) (0)
Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK (2013) (0)
Molecular recognition in protein complexes (1996) (0)
Non-human carbonyl hydrolase, DNA sequencing look and vectors encoding such and hosts transformed with such vectors (1987) (0)
A method for enrichment of protein variants with altered binding properties (1991) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000648a (2018) (0)
Growth factor variants of vascular endothelial cells, their uses and procedures. (1996) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000245b (2018) (0)
Unraveling the Mechanism of Cell Death Induced by Chemical and Protein Fibrils (2014) (0)
Enrichment process of variant proteins with altered binding properties (1991) (0)
Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000470b (2018) (0)
Low Micromolar Small Molecule Inhibitor of IL-2 (2004) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000540a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000466a (2018) (0)
Abstract PL04-03: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions. (2013) (0)
Crystal structure of wildtype human caspase-1 in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) (2006) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000657b (2018) (0)
Caspase-2 T380A bound with Ac-VDVAD-CHO (2011) (0)
Apo structure of phosphotyrosine (pYAb) scaffold (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000599c (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000645a (2018) (0)
Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cell Death (2017) (0)
Human procaspase-3, crystal form 2 (2013) (0)
Abstract SY31-01: Remodeling of the cell surface proteome in cancer (2021) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000293a (2018) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-876 (2000) (0)
Hypoxia is a dominant remodeler of the CD8+ T cell surface proteome relative to activation and regulatory T cell-mediated suppression (2021) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000619a (2018) (0)
The container with the anti-VEGF antibodies (1998) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000491a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000525a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000206a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000089a (2018) (0)
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE (1998) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000108a (2018) (0)
Author response: Global cellular response to chemotherapy-induced apoptosis (2013) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000740a (2018) (0)
Usually sporulating bacillus without the ability to secrete subtilisin or neutral protease cultures thereof, and procedure for the production of heterologous proteins thus (1993) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000163a (2018) (0)
Human procaspase-3, crystal form 1 (2013) (0)
Wnt/β-catenin signaling in the early mammalian anterior foregut endoderm (2011) (0)
New engineered peptide ligases and substrate phage libraries for understanding cellular proteolysis (2019) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000217b (2018) (0)
Identifying and antagonizing the interactions between layilin and glycosylated collagens. (2022) (0)
Crystal structure of human caspase-1 (Cys285->Ala, Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 1-methyl-3-trifluoromethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethyl)-amide (2006) (0)
Caspase-7 in complex with DICA allosteric inhibitor (2004) (0)
Strained, helix-forming peptides and methods to produce them (1997) (0)
Improved anti-phosphotyrosine antibody 4G10-S5-4D5 Fab complexed with phosphotyrosine peptide (2018) (0)
P097 REGULATION OF PANETH CELL LINEAGES FOR REGIONAL IMMUNE SPECIALIZATION TO CONTROL COMORBIDITY OF C. DIFFICILE INFECTION WITH IBD (2018) (0)
Multiconformer model of apo WT PTP1B with glycerol at 180 K (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000666a (2018) (0)
humanizing antibodies and process for producing them. (1998) (0)
Multiconformer model of apo WT PTP1B with glycerol at 278 K (2018) (0)
CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH TOSYL-D-PROLINE (2000) (0)
Crystal Structure of Human Interleukin-2 Complexed with SP-1985 (2002) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA000951b (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_XST00000692b (2018) (0)
Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide (2002) (0)
Structure fromfunction: Screening structural modelswith functional data (structure prediction/epitope mapping/human growth hormone/somatotropin/structural analysis) (1994) (0)
Prokaryotic carbonyl hydrolases, procedure, dna, vectors and transformed farmers for their production and these hydrolases containing detergent compositions. (1984) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000514a (2018) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000232a (2018) (0)
A process for the formation of humanized antibodies by random mutagenesis (1998) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000662a (2018) (0)
Patient-Derived in vitro and in vivo Organoid Models of Gastric Cancer (2017) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMSOA001176b (2018) (0)
A process for the production of humanized antibodies by randomized mutagenesis (1998) (0)
Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide (2013) (0)
Bacillus that can excrete neutral protease neither subtilisin yet. (1984) (0)
Table 3, In vitro ADME propertiesa for selected compounds (2011) (0)
Anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with phosphotyrosine peptide (2018) (0)
Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RF4 (2014) (0)
Crystal Structure of Human Interleukin-2 (2002) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000538a (2018) (0)
PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8 (2011) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000711a (2018) (0)
Caspase-2 bound with two copies of Ac-DVAD-CHO (2011) (0)
Unraveling the Mechanism of SBRT Response in EGFR-Addicted Pulmonary Adenocarcinoma by CRISPR/Cas9 Functional Genomics (2015) (0)
Crystal Structure of H-Ras G12C, GMPPNP-bound (2013) (0)
Method for making mutations at arbitrary site in coding region of protein (1993) (0)
Bacillus useful for producing subtilisin mutant (1993) (0)
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000017a (2018) (0)
A method for generating mutations at each location in kodeomraadet a protein and for the expression of the resulting mutant DNA moieties yielding mutant proteins. (1993) (0)
Crystal structure of caspase-3 DEVE peptide complex (2016) (0)

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