Jan G. J. Van De Winkel
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Jan G. J. Van De Winkelbiology Degrees
Biology
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Immunology
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Biology
Jan G. J. Van De Winkel's Degrees
- PhD Immunology University of Amsterdam
- Masters Biology University of Amsterdam
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(Suggest an Edit or Addition)Jan G. J. Van De Winkel's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice (1996) (459)
- Biology of Human Immunoglobulin G Fc Receptors (1991) (401)
- Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo (2009) (255)
- FcαRI-positive liver Kupffer cells: Reappraisal of the function of immunoglobulin A in immunity (2000) (253)
- FcgammaR polymorphisms: Implications for function, disease susceptibility and immunotherapy. (2003) (246)
- Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies (1997) (231)
- IgG receptor polymorphisms: risk factors for disease (1998) (193)
- Fcã Receptor Iia (Cd32) Polymorphism In Fulminant Meningococcal Septic (1994) (179)
- Fcã Receptor Iia (Cd32) Heterogeneity In Patients With Recurrent Bacterial Respiratory Tract Infections (1994) (166)
- FcαRI (CD89) as a Novel Trigger Molecule for Bispecific Antibody Therapy (1997) (124)
- Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18) (1999) (123)
- Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy (1993) (121)
- Clinical Relevance of Fcγ Receptor Polymorphisms (1997) (109)
- Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains (2011) (102)
- Resolution of cutaneous inflammation after local elimination of macrophages (2000) (98)
- Immunotherapeutic perspective for bispecific antibodies. (2000) (90)
- The FcγRIa (CD64) Ligand Binding Chain Triggers Major Histocompatibility Complex Class II Antigen Presentation Independently of Its Associated FcR γ-Chain (1999) (86)
- A novel PCR-based method for direct Fcγ receptor IIIa (CD16) allotyping (2000) (72)
- Differential binding to human FcγRIIa and FcγRIIb receptors by human IgG wildtype and mutant antibodies (2003) (72)
- Human antibodies as next generation therapeutics. (2001) (69)
- Effective Phagocytosis and Killing of Candida albicans via Targeting FcγRI (CD64) or FcαRI (CD89) on Neutrophils (1999) (69)
- Evidence for non-random distribution of Fcγ receptor genotype combinations (2003) (60)
- Fcγ receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti‐rheumatic drugs (2003) (60)
- CD16 on human γδ T lymphocytes: Expression, function, and specificity for mouse IgG isotypes (1992) (59)
- Anti‐GPIIb/IIIa (CD41) monoclonal antibody‐induced platelet activation requires Fc receptor‐dependent cell‐cell interaction (1991) (56)
- Severity of Guillain–Barré syndrome is associated with Fcγ Receptor III polymorphisms (2005) (53)
- Enhancement of Polymorphonuclear Cell-mediated Tumor Cell Killing on Simultaneous Engagement of FcγRI (CD64) and FcαRI (CD89) (2001) (52)
- Cross‐linking of Both Types of IgG Fc Receptors, FcγyRI and FcγyRII, Enhances Intracellular Free Ca2+ in the Monocytic Cell Line U937 (1990) (52)
- Human IgA Fc receptors (FcαR) (1998) (50)
- The novel tribody [(CD20)2xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells (2013) (49)
- The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity (1998) (47)
- Characterization of Two Fc Receptors for Mouse Immunoglobulins on Human Monocytes and Cell Lines (1987) (45)
- Human C-reactive protein does not bind to fcγRIIa on phagocyti cells (2001) (41)
- Activity of Two Types of Fc Receptors, FcγRI and FcγRII, in Human Monocyte Cytotoxicity to Sensitized Erythrocytes (1989) (40)
- The human Fc receptor for IgA (FcαRI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis (1999) (40)
- Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity (2012) (37)
- Human Fcγ receptor II: a standby receptor activated by proteolysis? (1990) (33)
- Synergism of interleukin 6 and 1α,25‐dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines (1992) (31)
- Polymorphism of the Human Fcγ Receptor II (CD32): Molecular Basis and Functional Aspects (1992) (29)
- Heparin-Induced Thrombocytopenia : New Insights Into the Impact of the Fc g RIIa-RH 131 Polymorphism (1998) (27)
- Fcγ receptor polymorphisms and periodontal status: a prospective follow‐up study (2006) (27)
- Leukocyte and complement activation by GM1-specific antibodies is associated with acute motor axonal neuropathy in rabbits (2007) (26)
- Ofatumumab, a Human Mab Targeting a Membrane-Proximal Small-Loop Epitope On CD20, Induces Potent NK Cell-Mediated ADCC. (2009) (26)
- Alternatively spliced forms of the human myeloid Fcα receptor (CD89) in neutrophils (2004) (26)
- A novel polymorphism of FcαRI (CD89) associated with aggressive periodontitis (2004) (26)
- A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcγRIIA transgenic mice (2005) (25)
- A Human FcγRI/CD64 Transgenic Model for In Vivo Analysis of (Bispecific) Antibody Therapeutics (1995) (24)
- Identification of Signaling Motifs Within Human FcyRIIa and FcyRIIb Isoforms (2000) (22)
- FcγRIa–γ‐chain complexes trigger antibody‐dependent cell‐mediated cytotoxicity (ADCC) in CD5+ B cell/macrophage IIA1.6 cells (1998) (21)
- Selective Enhancement of Leu Cam Expression by Interleukin 6 during Differentiation of Human Promonocytic U937 Cells (1991) (20)
- Neutrophil FcγRI as Target for Immunotherapy of Invasive Candidiasis (2001) (18)
- In situ depletion of CD4+ T cells in human skin by Zanolimumab (2007) (18)
- Binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab (OFA) or Rituximab (RTX) Promotes Complement Dependent Cytotoxicity (CDC), and Considerably Higher Levels of CDC Are Induced by OFA Than by RTX. (2008) (15)
- Direct targeting of genetically modified tumour cells to FcγRI triggers potent tumour cytotoxicity (2006) (15)
- Chemotherapy-Refractory Diffuse Large B-Cell Lymphomas (DLBCL) Are Effectively Killed by Ofatumumab-Induced Complement-Mediated Cytoxicity. (2007) (15)
- No association of FcγRIIa, FcγRIIIa and FcγRIIIb polymorphisms with MS (2003) (14)
- Daratumumab, a Novel Potent Human Anti-CD38 Monoclonal Antibody, Induces Significant Killing of Human Multiple Myeloma Cells: Therapeutic Implication. (2009) (14)
- A SINGLE INJECTION OF POLYETHYLENE-GLYCOL GRANULOCYTE COLONY-STIMULATING FACTOR STRONGLY PROLONGS SURVIVAL OF MICE WITH SYSTEMIC CANDIDIASIS (2000) (13)
- 214 POSTER Characterization of a recombinant, fully human monoclonal antibody directed against the human insulin-like growth factor-1 receptor (2006) (13)
- Size-dependent effect of IgA on the IgA Fc receptor (CD89) (1997) (12)
- Fc receptors: Role in biology and antibody therapy (2010) (12)
- Flow cytometric determination of FcγRIIa (CD32) polymorphism (2004) (11)
- Isotype‐specific cross‐linking of select human FcγR isoforms triggers release of IL‐6 (1993) (10)
- The Fc g RIa (CD64) Ligand Binding Chain Triggers Major Histocompatibility Complex Class II Antigen Presentation Independently of Its Associated FcR g -Chain (1999) (10)
- Therapeutic efficacy of Fc g RI/CD64-directed bispecific antibodies in B-cell lymphoma (2000) (9)
- Presence of CD 16 on Endothelial Cells in Heart Transplant Rejection: an Immunohistochemical Study (1992) (8)
- The FcγRIIa-polymorphic site as a potential target for acute graft-versus-host disease in allogeneic stem cell transplantation (2005) (8)
- Assignment of three human high-affinity Fcγ receptor I genes to chromosome 1, band q21.1 (2004) (8)
- Experimental autoimmune myasthenia gravis in mice expressing human immunoglobulin loci (2003) (7)
- Characterisation of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin’s lymphomas. (2004) (7)
- Effect of rIFN‐γ on Antibody‐Mediated Cytotoxicity via Human Monocyte IgG Fc Receptor II (CD32) (1992) (7)
- Fc (cid:2) RI (CD64) resides constitutively in lipid rafts (2008) (7)
- Complement Activation and Complement-Mediated Killing of B Cells Promoted by Anti-CD20 Monoclonal Antibodies (mAb) Rituximab and Ofatumumab Are Rapid, and Ofatumumab Kills Cells More Rapidly and with Greater Efficacy. (2007) (6)
- Molecular Basis for a Polymorphism of Human Fvy Receptor II ( CD 32 ) By (2003) (6)
- Recombinant CD 64-Specific Single Chain Immunotoxin Exhibits Specific Cytotoxicity against Acute Myeloid Leukemia Cells (2003) (6)
- Cell‐bound IgE and increased expression of Faɛ‐receptors on dendritic cells in cutaneous infiltrates of mycosis fungoides (1991) (5)
- Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain–Barré syndrome (2007) (5)
- Fully Human CD38 Antibodies Efficiently Trigger ADCC of Multiple Myeloma Cell Lines and Primary Tumor Cells. (2005) (4)
- The cytoplasmic domain of Fc g RIIA (CD32) participates in phagolysosome formation (2001) (4)
- Chemotherapy-refractory diffuse large B-cell lymphomas (DLBCL) are effectively killed by CD20 antibody-induced complement-mediated cytotoxicity (2011) (4)
- Complement (C) Activation Followed by Penetration of the Membrane Attack Complex (MAC) on B Cells Opsonized with CD20 Mabs Allows for Calcium Influx Which Induces Streamers. Generalization of Streaming to Include other Mabs and Target Cells. (2008) (3)
- IgG and complement receptor expression in children treated by peritoneal dialysis (2005) (3)
- Protein 4.1G binds to a unique motif within the Fc (cid:2) RI cytoplasmic tail (2008) (3)
- Spinning disk confocal fluorescent microscopy (SDCFM) analyses of complement activation promoted by anti-CD20 mAbs rituximab and ofatumumab (HuMax-CD20) (2007) (2)
- [Immunology in clinical practice. X. IgG receptors: structure, function and immunotherapy]. (1998) (2)
- Mimicking An Induced Self Phenotype by Coating Lymphomas with the Nkp30-Ligand B7-H6 Promotes Antitumoral Natural Killer Cell Cytotoxicity (2011) (2)
- Granulocyte-Macrophage Colony-Stimulating Factor Induces Sequential Activation and Deactivation of Binding Via a Low-Affinity IgG Fc Receptor , hFcyRII , on Human Eosinophils (2003) (2)
- FcR and autoimmunity (1998) (1)
- HLA Class I 1 as Potential Target Antigen on Malignant B Cells for Therapy With Bispecific Antibodies in Combination With Granulocyte Colony-Stimulating Factor (2002) (1)
- Role of ADCC in the in vivo antitumor effects of zalutumumab, a human anti-EGF receptor antibody. (2010) (1)
- Fcγ Receptors of Myeloid Cells (1993) (1)
- formation RIIA (CD32) participates in phagolysosome γ The cytoplasmic domain of Fc (2013) (1)
- Expression of CD64 (FcγRI) in skin of patients with acute GVHD (2011) (1)
- Ineffi cient antigen presentation via the IgA Fc receptor (FcαRI) on Dendritic Cells (2006) (1)
- Bispeciffic antibody MDX210 (FcγRI × HER-2/neu) in combination with G-CSF: Results of a phase I trial in patients with metastatic breast cancer (1997) (1)
- Anti-pneumococcal Antibodies in Mice Protection by Human IgG 1 and IgG 2 Central Role of Complement in Passive (2003) (0)
- Novel antibody therapeutics for treatment of cancer and inflammation (2002) (0)
- Transgenic Mice Potent Humoral Responses in Human CD64 Targeting Weak Antigens to CD64 Elicits (2000) (0)
- CD 20-Directed Antibody Therapy Neutrophils as Effector Cells for-Receptor I ( CD 89 ) Recruits α Triggering FC (2000) (0)
- Recurrent bacterial respiratory tract infections; IgG-subclasses, selective antipolysaccharide antibody deficiency and FcγRlla-receptor polymorphism (1997) (0)
- Complement-dependent lysis of mAb-opsonized B cells can increase resistance of naive B cells to subsequent attack by mAb and complement (2010) (0)
- Combined administration of G-CSF and anti-FcγRi bispecific antibodies generates HER2/neu-specific cytotoxic neutrophils (1997) (0)
- F.117. FcγRiv Required for Succesfull Prevention of Liver Metastases Development After Antibody Therapy (2006) (0)
- Affinity IgG Receptor , Fc Functional Characteristics of the High Winkel (2011) (0)
- receptor, Fc{gamma}RI, in the presence of monomeric IgG Cytokine-induced immune complex binding to the high-affinity IgG (2010) (0)
- Reply to Fab-arm exchange (2010) (0)
- D/Anti-CD89 Protein Neutrophils via Chimeric Surfactant Protein Effective Targeting of Pathogens to (2004) (0)
- Recombinant chimeric IgA1 and IgA2 antibodies for tumor immunotherapy (2007) (0)
- Characteristics and Interrelation of 2 Types of Immunoglobulin-G Fc-Receptors on Human-Monocytes (1988) (0)
- Fusion Proteins of Ligands for NKG2D and CD20-Directed ScFvs Sensitize Lymphomas for NK Cell-Mediated Lysis (2010) (0)
- Anticorps monoclonaux anti-cd32b (2008) (0)
- Antagonists That Inhibit IgG-Mediated R γ Homologue FLIPr-like Are Potent Fc like 1 Inhibitor (FLIPr) and Its - Receptor Formyl Peptide Staphylococcus aureus (2013) (0)
- Receptor Receptor CD 89 and Consequences for Fc Signaling through Mutants of the IgA (2006) (0)
- Syddansk Universitet CD 20-Specific Immunoligands Engaging NKG 2 D Enhance T Cell-Mediated Lysis of Lymphoma Cells (2017) (0)
- Epitopes on CD 20 Monoclonal Antibodies Is Linked to Unique The Biological Activity of Human CD 20 (2006) (0)
- B7-H6 Promotes NK Cell Cytotoxicity Coating Lymphomas with the NKp30 Ligand Mimicking an Induced Self Phenotype by (2012) (0)
- Anti-P-selectin (2005) (0)
- ReceptorAntibodies against Epidermal Growth Factor Effector Mechanisms of Recombinant IgA (2007) (0)
- Effector proteins of the high affinity IgG receptor, CD64 (2006) (0)
- Therapeutics , Targets , and Chemical Biology Cancer Research In vivo Cytotoxicity of Type I CD 20 Antibodies Critically Depends on Fc Receptor ITAM Signaling (2010) (0)
- Human immunoglobulin A receptor (Fc alpha RI, CD89) as target for immunotherapy (2001) (0)
- IgG-mediated anaphylaxis and inflammation are impaired in mice lacking FcγRIII (1997) (0)
- Induced by OFA than by RTX Considerably Higher Levels of CDC Are Ofatumumab (OFA) or Rituximab (RTX): of B Cells Opsonized with Anti-CD20 mAbs Complement-Dependent Cytotoxicity (CDC) Binding of Submaximal C1q Promotes (2009) (0)
- Antibody-Dependent Cellular Cytotoxicity Growth Factor Receptor Effectively Trigger Human IgG2 Antibodies against Epidermal (2009) (0)
- Lung cancer-derived EGFR mutations affect responses to tyrosine kinase inhibitors, but not to monoclonal antibodies (2007) (0)
- This information is current as EGFR Kinase Mutations Are Not Affected by Lung Cancer-Associated Growth Factor Receptor (EGFR) Antibodies Tumor Cell Killing Mechanisms of Epidermal (2013) (0)
- Polymorphism and functioning of a low-affinity IgG Fc receptor, hFcγRII (CD32) (1992) (0)
- Serogroup B meningitidis Neisseria Immune Defense Against Activity of Human IgG and IgA Subclasses in and (2001) (0)
- 222 Ofatumumab binds to a membrane-proximal epitope which comprises amino acids in the small and large loops of CD20 (2010) (0)
- Direct Internalization by the B Cells Fc Receptor-Expressing Effector Cells Than Rapidly Because of Trogocytosis Mediated by from Opsonized B Cells Occurs More Loss of CD20 and Bound CD20 Antibody (2011) (0)
- Binding characteristics of human serum IgA to CD89 (1997) (0)
- Induction and effector phase of experimental allergic encephalomyelitis are independent of the Fc gamma chain (2004) (0)
- Metastases Reveals Functional Redundancy Experimental Antibody Therapy of Liver (2008) (0)
- Myeloid Lineage but , in Contrast to IgG 1 , Only by Cells of Antibody-Dependent Cellular Cytotoxicity Growth Factor Receptor Effectively Trigger Human IgG 2 Antibodies against Epidermal (2009) (0)
- Role of FcRn in phagocytes (2006) (0)
- MolecularBasisfora Polymorphism ofHuman Fvy ReceptorII(CD32) (1990) (0)
- Recombinant Dimeric IgA Antibodies as Tumor-Specific Agents. (2010) (0)
- Antibodies to factor receptor I insulin-like growth and use thereof (2004) (0)
- Bordetellapertussisattachment to respiratory epithelial cells can be impaired by ¢mbriae-speci¢c antibodies (2005) (0)
- Mediate Effective Tumor Cell Killing the Epidermal Growth Factor Receptor Recombinant Dimeric IgA Antibodies against (2011) (0)
- Candidate targets for antibody therapy of rheumatoid arthritis: CD64 and IL-15 (2003) (0)
- -Chain Interaction g Receptor Receptor CD89 and Consequences for Fc Signaling through Mutants of the IgA (2006) (0)
- 252Type I CD20 antibodies take over the B-cell receptor for complement-dependent cytotoxicity (CDC) of malignant B cells (2012) (0)
- Human monocyte FcÚ receptors (1988) (0)
- Cytokine-induced immune complex binding to the high-affinity IgG receptor, Fc (cid:1) RI, in the presence of monomeric IgG (2010) (0)
- Effect of combinations of EGF-R antibodies on complement-dependent tumor cell lysis (2008) (0)
- FcγRI receptor complexes in mouse B-cells trigger phagocytosis, cytokine production and ADCC (1997) (0)
- Hematological Tumors of Multiple Myeloma and Other CD38 Monoclonal Antibody, Induces Killing Daratumumab, a Novel Therapeutic Human (2010) (0)
- A New Human CD20 Antibody for Improved Killing of CD20-Transgenic T Cells for Allogeneic Stem Cell Transplantation. (2005) (0)
- Chimeric IgA antibodies for lymphoma therapy (2001) (0)
- Development of an Effective Safety Switch for Selective Elimination of Human T Cells In Vivo after Adoptive Transfer. (2006) (0)
- Activity in Palmoplantar Pustulosis ClinicalInflammatory Diseases : Reduction of IL-8 as Antibody Therapeutic Target in (2008) (0)
- Boosting ADCC activity of therapeutic antibodies by concomitant stimulation of Fc gamma RIIIa and activating NK cell receptors (2015) (0)
- Effector proteins of Fc{gamma}RI: inside-out and outside-in regulation (2009) (0)
- The Novel Bispecific Antibody [(CD20) 2 xCD16] Efficiently Triggers Lysis of Neoplastic B Cells (2010) (0)
- Fc receptors: historical perspectives and a look to the future (1998) (0)
- Mechanisms of cooperation of Fc-alpha-RI (CD89) and Mac-1 (CD11b/CD18) in tumor cytotoxicity; implications for immunotherapy (2002) (0)
- Anticorps igg4 stables (2008) (0)
- 428. Development of an Effective Safety Switch for Selective Elimination of Human T Cells In Vivo after Adoptive Transfer (2006) (0)
- Spinning Disk Confocal Fluorescent Microscopy (SDCFM) Analyses of Complement Activation Promoted by Anti-CD20 Monoclonal Antibodies (mAbs) Rituximab and Ofatumumab. (2007) (0)
- Spinning Disk Confocal Fluorescent Microscopy (SDCFM) Analyses of Complement Activation Promoted by Anti-CD20 Monoclonal Antibodies (mAbs) Rituximab and Ofatumumab. (2007) (0)
- BISPECIFIC ANTIBODIES AND CYTOKINE-STIMULATED EFFECTOR CELLS: NEW OPTIONS FOR IMMUNOTHERAPY OF RENAL CELL CARCINOMA (1999) (0)
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