Jan Hoeijmakers | Academic Influence

Jan Hoeijmakers's AcademicInfluence.com Rankings

Jan Hoeijmakers

Biology

#1854

World Rank

#3007

Historical Rank

Molecular Biology

#210

World Rank

#214

Historical Rank

biology Degrees

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Biology

Jan Hoeijmakers's Degrees

PhD Molecular Biology University of Amsterdam

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According to Wikipedia, Jan Hendrik Jozef Hoeijmakers is a Dutch molecular biologist, biochemist, and molecular geneticist. Education and career Hoeijmakers studied biology from 1969 at the Radboud University Nijmegen with receiving his MSc degree in molecular biology in 1975 . At the University of Amsterdam he performed his doctoral research from 1975 to 1979 and then was a lecturer at the department of microbiology from 1979 to 1981. He obtained a PhD in molecular medicine in 1981 from the University of Amsterdam under Piet Borst with dissertation Trypanosomes: Kinetoplast DNA and Antigenic Variation. At Erasmus University Rotterdam, as a member of Dirk Bootsma's group in the Institute of Genetics, Hoeijmakers was, in the department of cell biology and genetics, a senior scientist from 1981 to 1985, an associate professor from 1985 to 1993, and a professor of molecular genetics from 1993 to the present. The Royal Netherlands Academy of Arts and Sciences sponsored him as an Academy Professor from 2011 to 2016. He is the author or co-author of over 490 scientific publications. He has served on the editorial boards of five scientific journals.

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Jan Hoeijmakers's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genome maintenance mechanisms for preventing cancer (2001) (4012)
DNA damage, aging, and cancer. (2009) (1910)
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms (1999) (1327)
Chromosomal stability and the DNA double-stranded break connection (2001) (1255)
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. (2014) (1187)
Molecular mechanism of nucleotide excision repair. (1999) (1140)
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age (2007) (1042)
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. (1998) (932)
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017) (877)
Understanding nucleotide excision repair and its roles in cancer and ageing (2014) (838)
Sequential assembly of the nucleotide excision repair factors in vivo. (2001) (822)
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. (1993) (772)
Nucleotide excision repair and human syndromes. (2000) (701)
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes (1992) (669)
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis (2006) (642)
p53 modulation of TFIIH–associated nucleotide excision repair activity (1995) (590)
Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease (1996) (577)
Aging and Genome Maintenance: Lessons from the Mouse? (2003) (576)
Molecular mechanisms of DNA double strand break repair. (1998) (560)
Cellular senescence drives age-dependent hepatic steatosis (2017) (554)
Premature Aging in Mice Deficient in DNA Repair and Transcription (2002) (535)
The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks (2004) (491)
Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination (1997) (463)
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor (1994) (454)
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice (2000) (442)
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. (2003) (410)
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. (1994) (410)
Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification (1996) (409)
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome (1990) (404)
Action of DNA repair endonuclease ERCC1/XPF in living cells. (1999) (389)
Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock. (1999) (380)
ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor (2000) (365)
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence (1997) (356)
DNA damage and ageing: new-age ideas for an age-old problem (2008) (355)
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. (1996) (352)
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A (2004) (337)
Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition (1997) (331)
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. (1998) (330)
Fanconi Anemia (Cross)linked to DNA Repair (2005) (305)
Silencing of Unpaired Chromatin and Histone H2A Ubiquitination in Mammalian Meiosis (2005) (295)
ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair (2008) (295)
Molecular cloning of a human DNA repair gene (1984) (293)
Nucleocytoplasmic shuttling and mCRY‐dependent inhibition of ubiquitylation of the mPER2 clock protein (2002) (288)
Nucleotide excision repair. II: From yeast to mammals. (1993) (282)
Histone ubiquitination and chromatin remodeling in mouse spermatogenesis. (1999) (281)
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage (2002) (279)
A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. (2003) (275)
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks (2008) (271)
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (2006) (269)
Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10 (1986) (262)
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. (1990) (258)
The Cockayne syndrome B protein, involved in transcription‐coupled DNA repair, resides in an RNA polymerase II‐containing complex (1997) (256)
Homologous and non‐homologous recombination differentially affect DNA damage repair in mice (2000) (255)
Rec8p, a Meiotic Recombination and Sister Chromatid Cohesion Phosphoprotein of the Rad21p Family Conserved from Fission Yeast to Humans (1999) (252)
RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6. (1994) (250)
Age to survive: DNA damage and aging. (2008) (249)
Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. (1991) (244)
MicroRNA‐mediated gene silencing modulates the UV‐induced DNA‐damage response (2009) (244)
Overproduction of the poly(ADP‐ribose) polymerase DNA‐binding domain blocks alkylation‐induced DNA repair synthesis in mammalian cells. (1993) (238)
Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome (2006) (235)
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. (1995) (235)
Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase. (1997) (230)
DNA Structural Elements Required for ERCC1-XPF Endonuclease Activity* (1998) (229)
Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. (2002) (228)
Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation (1999) (225)
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis (2016) (225)
Short‐term dietary restriction and fasting precondition against ischemia reperfusion injury in mice (2010) (225)
Interaction of hHR23 with S5a (1999) (220)
Engagement with transcription (1993) (216)
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair (2012) (211)
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. (2007) (210)
Powerful Skin Cancer Protection by a CPD-Photolyase Transgene (2005) (209)
The core spliceosome as target and effector of non-canonical ATM signaling (2015) (208)
2-Acetylaminofluorene-modified probes for the indirect hybridocytochemical detection of specific nucleic acid sequences. (1984) (204)
Novel expression-linked copies of the genes for variant surface antigens in trypanosomes (1980) (202)
Different types of V(D)J recombination and end‐joining defects in DNA double‐strand break repair mutant mammalian cells (2002) (202)
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. (1998) (201)
Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms (2008) (196)
Dimerization and nuclear entry of mPER proteins in mammalian cells. (2000) (195)
Mouse RAD54 Affects DNA Double-Strand Break Repair and Sister Chromatid Exchange (2000) (188)
TFIIH with Inactive XPD Helicase Functions in Transcription Initiation but Is Defective in DNA Repair* (2000) (183)
MARK-AGE biomarkers of ageing (2015) (179)
HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro (1996) (173)
Xeroderma Pigmentosum Group A Protein Loads as a Separate Factor onto DNA Lesions (2003) (171)
The central role of DNA damage in the ageing process (2021) (168)
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F. (1993) (167)
The structure‐specific endonuclease Ercc1—Xpf is required for targeted gene replacement in embryonic stem cells (2001) (167)
Divide and conquer: nucleotide excision repair battles cancer and ageing. (2003) (166)
Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV‐induced DNA breaks (2005) (164)
A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy. (1997) (157)
Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation (1996) (155)
DNA damage stabilizes interaction of CSB with the transcription elongation machinery (2004) (154)
The Human Rad54 Recombinational DNA Repair Protein Is a Double-stranded DNA-dependent ATPase* (1998) (145)
Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3. (1994) (142)
Nuclear Genomic Instability and Aging. (2018) (141)
Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice (2016) (141)
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols (2002) (140)
Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity (1997) (140)
The DNA damage response to transcription stress (2019) (139)
Global Regulation of Promoter Melting in Naive Lymphocytes (2013) (139)
Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice (2005) (138)
Translocation of Cockayne syndrome group A protein to the nuclear matrix: Possible relevance to transcription-coupled DNA repair (2002) (137)
Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction (2012) (137)
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. (1999) (136)
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009) (136)
The role of DNA dependent protein kinase in synapsis of DNA ends (2003) (136)
Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment (2014) (135)
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice. (2003) (134)
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. (2005) (133)
Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder (2000) (133)
Disruption of Mouse SNM1 Causes Increased Sensitivity to the DNA Interstrand Cross-Linking Agent Mitomycin C (2000) (133)
Dysregulation of the Peroxisome Proliferator-Activated Receptor Target Genes by XPD Mutations (2005) (130)
XAB2, a Novel Tetratricopeptide Repeat Protein Involved in Transcription-coupled DNA Repair and Transcription* (2000) (129)
XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes (1996) (126)
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC (2008) (126)
Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. (2002) (125)
Mutational analysis of the human nucleotide excision repair gene ERCC1. (1996) (124)
Involvement of Global Genome Repair, Transcription Coupled Repair, and Chromatin Remodeling in UV DNA Damage Response Changes during Development (2010) (123)
Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome. (1995) (123)
Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein. (1994) (123)
A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy. (1993) (122)
Mapping of interaction domains between human repair proteins ERCC1 and XPF. (1998) (122)
Cockayne syndrome: defective repair of transcription? (1997) (119)
The Ubiquitin-Conjugating DNA Repair Enzyme HR6A Is a Maternal Factor Essential for Early Embryonic Development in Mice (2004) (117)
Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH). (1994) (116)
DNA bending by the human damage recognition complex XPC-HR23B. (2003) (115)
Loss of HR6B Ubiquitin-Conjugating Activity Results in Damaged Synaptonemal Complex Structure and Increased Crossing-Over Frequency during the Male Meiotic Prophase (2003) (113)
Developmental Defects and Male Sterility in Mice Lacking the Ubiquitin-Like DNA Repair Gene mHR23B (2002) (113)
The CSB Protein Actively Wraps DNA* (2005) (112)
Recruitment of the Nucleotide Excision Repair Endonuclease XPG to Sites of UV-Induced DNA Damage Depends on Functional TFIIH (2006) (112)
Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination. (1994) (112)
Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne Syndrome Group B DNA repair genes (2001) (111)
Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair (2011) (111)
Xeroderma pigmentosum complementation group G associated with Cockayne syndrome. (1993) (111)
Molecular cloning and biological characterization of the human excision repair gene ERCC-3 (1990) (111)
Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality. (1998) (110)
Molecular cloning of the human DNA excision repair gene ERCC-6 (1990) (110)
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. (2006) (109)
Tumor slice culture system to assess drug response of primary breast cancer (2016) (108)
Identification and characterization of XPC-binding domain of hHR23B (1997) (108)
Biochemical and Biological Characterization of Wild-type and ATPase-deficient Cockayne Syndrome B Repair Protein* (1998) (108)
p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. (1994) (107)
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. (2002) (106)
Serum N-glycan profile shift during human ageing (2010) (105)
RAD25 (SSL2), the yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viability. (1992) (104)
Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei (1978) (103)
Postmeiotic transcription of X and Y chromosomal genes during spermatogenesis in the mouse. (1995) (103)
Dynamic Interaction of TTDA with TFIIH Is Stabilized by Nucleotide Excision Repair in Living Cells (2006) (103)
Double mutants of Saccharomyces cerevisiae with alterations in global genome and transcription-coupled repair (1996) (103)
A temperature-sensitive disorder in basal transcription and DNA repair in humans (2001) (102)
Priming of microglia in a DNA-repair deficient model of accelerated aging (2012) (102)
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. (1980) (101)
Nucleotide excision repair I: from E. coli to yeast. (1993) (101)
MicroRNAs, the DNA damage response and cancer. (2011) (95)
The major transcripts of the kinetoplast DNA of Trypanosoma brucei are very small ribosomal RNAs (1983) (95)
Nucleotide excision repair–initiating proteins bind to oxidative DNA lesions in vivo (2012) (95)
Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice (2002) (94)
Broad segmental progeroid changes in short-lived Ercc1−/Δ7 mice (2011) (93)
Different Effects of CSA and CSB Deficiency on Sensitivity to Oxidative DNA Damage (2004) (93)
Analysis of mouse Rad54 expression and its implications for homologous recombination. (2002) (92)
Nucleotide Excision Repair Disorders and the Balance Between Cancer and Aging (2006) (91)
Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options. (2016) (90)
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells. (2009) (90)
Molecular genetics of eukaryotic DNA excision repair. (1990) (89)
Differences between rodent and human cell lines in the amount of integrated DNA after transfection. (1987) (88)
Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. (1996) (88)
Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. (1996) (87)
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice (2010) (87)
A 3′ → 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and Transcription* (1996) (86)
Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases. (1995) (86)
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. (1997) (86)
In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair. (2004) (86)
A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells (2009) (84)
Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair. (1999) (84)
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. (2006) (84)
Retinal Degeneration and Ionizing Radiation Hypersensitivity in a Mouse Model for Cockayne Syndrome (2006) (81)
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. (2005) (80)
Characterization of DNA from Trypanosoma brucei and related trypanosomes by restriction endonuclease digestion (1980) (80)
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex. (2004) (78)
Plant homologue of human excision repair gene ERCC1 points to conservation of DNA repair mechanisms. (1998) (78)
Genome maintenance mechanisms are critical for preventing cancer as well as other aging-associated diseases (2007) (76)
Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease (2016) (75)
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease (2018) (74)
Architecture of nucleotide excision repair complexes: DNA is wrapped by UvrB before and after damage recognition (2001) (74)
Xeroderma pigmentosum complementation group H falls into complementation group D. (1991) (73)
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH (1997) (73)
Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6. (1991) (73)
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. (2008) (72)
Nucleotide excision repair syndromes: molecular basis and clinical symptoms. (1995) (71)
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition. (1999) (71)
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts. (2008) (69)
Recognition of DNA damage by XPC coincides with disruption of the XPC–RAD23 complex (2012) (69)
A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic ‘tail’ absent from purified glycoprotein (1980) (69)
Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice (2006) (68)
Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B. (1993) (68)
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage‐dependent recombination (2004) (68)
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing (2012) (66)
Dynamics of relative chromosome position during the cell cycle. (2004) (65)
Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23. (1996) (65)
Cell biology: Ageing nucleus gets out of shape (2006) (65)
The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I. (1989) (64)
Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology (2011) (64)
Recombination and joining: different means to the same ends. (1997) (62)
Genomic characterization of the human DNA excision repair gene ERCC-1. (1987) (62)
Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs (2013) (62)
An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair (2008) (61)
Mammalian nucleotide excision repair. (1995) (61)
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase. (2011) (60)
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging (2016) (60)
Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (1992) (58)
The kinetoplast DNA of Trypanosoma equiperdum. (1980) (58)
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function (1994) (57)
Variations in maxi-circle and mini-circle sequences in kinetoplast DNAs from different Trypanosoma brucei strains. (1980) (56)
DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells. (1996) (56)
Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer (2006) (56)
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human (2015) (55)
Evolution and mutagenesis of the mammalian excision repair gene ERCC-1. (1988) (54)
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes. (2003) (52)
Menopause: Genome stability as new paradigm. (2016) (52)
Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer (2019) (52)
Transcription of kinetoplast DNA in Trypanosoma brucei bloodstream and culture forms. (1981) (52)
Aging: not all DNA damage is equal. (2014) (52)
Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase (2004) (52)
MicroRNA responses and stress granule formation modulate the DNA damage response (2009) (51)
Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation (2009) (51)
Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration (2011) (51)
DNA damage in normally and prematurely aged mice (2013) (51)
Transcription-Coupled and Global Genome Repair Differentially Influence UV-B-Induced Acute Skin Effects and Systemic Immunosuppression1 (2000) (50)
Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes. (1995) (49)
The segregation of kinetoplast DNA networks in Trypanosoma brucei. (1980) (49)
DNA repair. Engagement with transcription. (1993) (49)
UV stimulation of DNA-mediated transformation of human cells (1985) (49)
Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions (1989) (48)
The genetic basis of xeroderma pigmentosum. (1991) (47)
Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency (2014) (47)
Altered lipid metabolism in the aging kidney identified by three layered omic analysis (2016) (47)
Sealing the gap between nuclear DNA damage and longevity (2009) (47)
DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity (2014) (47)
Microinjection of Micrococcus luteus UV-endonuclease restores UV-induced unscheduled DNA synthesis in cells of 9 xeroderma pigmentosum complementation groups. (1985) (46)
Genes controlling nucleotide excision repair in eukaryotic cells (1993) (46)
A long-range restriction map of the human chromosome 19q13 region: close physical linkage between CKMM and the ERCC1 and ERCC2 genes. (1990) (45)
DNA rearrangements involving the genes for variant antigens in Trypanosoma brucei. (1981) (44)
Knockout mouse model and gametogenic failure (1998) (44)
Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1−/Δ7 Mice (2016) (44)
RNA from the insect trypanosome Crithidia luciliae contains transcripts of the maxi-circle and not of the mini-circle component of kinetoplast DNA. (1978) (43)
Mammalian nucleotide excision repair and syndromes. (1997) (42)
Phosphodiesterase 1 regulation is a key mechanism in vascular aging. (2015) (42)
Cellular Concentrations of DDB2 Regulate Dynamic Binding of DDB1 at UV-Induced DNA Damage (2008) (42)
Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers (2017) (42)
The molecular basis of nucleotide excision repair syndromes. (1994) (42)
Genetic analysis of nucleotide excision repair in mammalian cells. (1993) (41)
Deletion of the Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching and Alters Mutations Near Switch Recombination Junctions (2004) (40)
Cockayne syndrome pathogenesis: Lessons from mouse models (2013) (40)
Affinity Purification of Human DNA Repair/Transcription Factor TFIIH Using Epitope-tagged Xeroderma Pigmentosum B Protein* (1998) (40)
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. (2016) (40)
Maxi-circles and mini-circles in kinetoplast DNA from trypanosoma cruzi. (1980) (40)
Microinjection of human cell extracts corrects xeroderma pigmentosum defect. (1983) (39)
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. (2006) (39)
DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals (2013) (39)
Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21. (1992) (38)
Kinetoplast DNA (1993) (38)
Genetic recombination: From competition to collaboration (1998) (37)
DNA damage‐induced replication stress results in PA200‐proteasome‐mediated degradation of acetylated histones (2018) (37)
ERCC 1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair † (2008) (36)
Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality (2013) (35)
Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. (2000) (35)
Use of in vivo and in vitro assays for the characterization of mammalian excision repair and isolation of repair proteins. (1990) (35)
The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair (2006) (34)
Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging (2007) (34)
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin (2019) (34)
Transfection of the cloned human excision repair gene ERCC-1 to UV-sensitive CHO mutants only corrects the repair defect in complementation group-2 mutants. (1988) (34)
Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF. (2001) (33)
Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice (2009) (33)
Scanning confocal fluorescence microscopy for single molecule analysis of nucleotide excision repair complexes. (2002) (32)
Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging. (2012) (32)
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. (1998) (32)
Transient correction of excision repair defects in fibroblasts of 9 xeroderma pigmentosum complementation groups by microinjection of crude human cell extracts. (1986) (32)
Correction: Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome (2008) (32)
Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice. (2001) (31)
Genome stability, progressive kidney failure and aging (2012) (31)
Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4. (1997) (31)
Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities. (1995) (31)
Establishment and characterization of a melanoma cell line from a xeroderma pigmentosum patient: activation of N-ras at a potential pyrimidine dimer site. (1989) (31)
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering (2019) (31)
The DNA damage response: the omics era and its impact. (2014) (30)
Homeostatic Imbalance between Apoptosis and Cell Renewal in the Liver of Premature Aging XpdTTD Mice (2008) (30)
Kinetoplast DNA in the insect trypanosomes Crithidia luciliae and Crithidia fasciculata. I. Sequence evolution and transcription of the maxicircle. (1982) (30)
A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction (2017) (30)
Incisions for excision (1994) (29)
Rescue of Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles (2006) (29)
Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21. (1991) (29)
Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue (2017) (28)
Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. (2019) (28)
Pre‐operative dietary restriction is feasible in live‐kidney donors (2011) (28)
Human RAD18 Interacts with Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA Double Strand Breaks (2011) (28)
Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome. (1991) (27)
Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases. (2000) (27)
Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene, ERCC3. (1992) (27)
Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair. (2009) (26)
Effects of microinjected photoreactivating enzyme on thymine dimer removal and DNA repair synthesis in normal human and xeroderma pigmentosum fibroblasts. (1990) (26)
The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition. (2012) (26)
Nucleotide excision repair in chronic neurodegenerative diseases. (2013) (26)
Characterization of Genes and Proteins Involved in Excision Repair of Human Cells (1987) (25)
Nucleotide excision repair and its connection with cancer and ageing. (2005) (25)
ARDD 2020: from aging mechanisms to interventions (2020) (25)
Spatio-temporal Analysis of Molecular Determinants of Neuronal Degeneration in the Aging Mouse Cerebellum* (2013) (25)
Transcriptional Healing (2000) (25)
Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome. (1991) (25)
Preoperative Fasting Protects against Renal Ischemia-Reperfusion Injury in Aged and Overweight Mice (2014) (25)
Characterization of kinetoplast DNA networks from the insect trypanosome Crithidia luciliae. (1977) (25)
Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. (1994) (25)
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. (2003) (24)
Kinetoplast DNA in the insect trypanosomes Crithidia luciliae and Crithidia fasciculata. II. Sequence evolution of the minicircles. (1982) (24)
TTDA: big impact of a small protein. (2014) (24)
STRUCTURE AND FUNCTION OF KINETOPLAST DNA OF THE AFRICAN TRYPANOSOMES (1979) (24)
DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1 (2018) (24)
After surviving cancer, what about late life effects of the cure? (2016) (23)
Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells. (1994) (23)
Complementation group assignments of moderately UV-sensitive CHO mutants isolated by large-scale screening (FAECB). (1994) (22)
The HhH domain of the human DNA repair protein XPF forms stable homodimers (2007) (22)
Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice (2017) (22)
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice. (2005) (21)
Deciphering the RNA landscape by RNAome sequencing (2015) (21)
Xeroderma pigmentosum group A correcting protein from calf thymus. (1992) (21)
Molecular and functional analysis of the XPBC/ERCC-3 promoter: transcription activity is dependent on the integrity of an Sp1-binding site. (1992) (21)
Filter radioimmunoassay, a method for large-scale serotyping of Neisseria meningitidis (1984) (20)
Microinjection of Escherichia coli UvrA, B, C and D proteins into fibroblasts of xeroderma pigmentosum complementation groups A and C does not result in restoration of UV-induced unscheduled DNA synthesis. (1986) (20)
Microinjected photoreactivating enzymes from Anacystis and Saccharomyces monomerize dimers in chromatin of human cells. (1985) (20)
Fluorescence Correlation Spectroscopy of the Binding of Nucleotide Excision Repair Protein XPC-hHr23B with DNA Substrates (2008) (20)
Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT-) using an Epstein-Barr virus-derived cDNA expression vector. (1991) (19)
Molecular mechanisms of nucleotide excision repair (2001) (19)
Glucose Supplementation Does Not Interfere With Fasting-Induced Protection Against Renal Ischemia/Reperfusion Injury in Mice (2011) (19)
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice (2011) (19)
Meningococcal disease in The Netherlands, 1959-1981: the occurrence of serogroups and serotypes 2a and 2b of Neisseria meningitidis. (1986) (19)
Meiotic functions of RAD18 (2011) (19)
Aging on a different scale – chronological versus pathology-related aging (2013) (19)
BACH2: a marker of DNA damage and ageing. (2013) (18)
Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene. (1991) (18)
Augmentation of protein production by a combination of the T7 RNA polymerase system and ubiquitin fusion: overproduction of the human DNA repair protein, ERCC1, as a ubiquitin fusion protein in Escherichia coli. (1993) (18)
The kinetoplast DNA of Trypanosoma brucei: structure, evolution, transcription, mutants. (1980) (17)
Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging (2013) (17)
How relevant is the Escherichia coli UvrABC model for excision repair in eukaryotes? (1991) (17)
Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling (2019) (17)
Dietary restriction modifies certain aspects of the postoperative acute phase response. (2011) (16)
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid (2017) (16)
Structure of the nuclear pore complex in mammalian cells. Two annular components. (1974) (16)
Expression and possible functions of DNA lesion bypass proteins in spermatogenesis. (2005) (16)
The genes for variant antigens in trypanosomes. (1980) (16)
Structure, function and evolution of kinetoplast DNA. (1981) (16)
Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice. (2016) (15)
Age-Related Skeletal Dynamics and Decrease in Bone Strength in DNA Repair Deficient Male Trichothiodystrophy Mice (2012) (15)
Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1 δ/− mouse (2012) (15)
Vitamin E Supplementation Reduces Cellular Loss in the Brain of a Premature Aging Mouse Model. (2017) (14)
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice (2021) (14)
The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PKCS Deficiency (2014) (13)
From a DNA helicase to brittle hair (1998) (13)
Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/- mice. (2017) (12)
Identification of DNA repair genes in the human genome. (1986) (12)
Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy. (2007) (12)
Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy (2021) (12)
A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. (1998) (12)
Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy (2010) (11)
DNA repair: two pieces of the puzzle (1992) (11)
DNA repair in human cells: from genetic complementation to isolation of genes. (1988) (11)
The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex* (2015) (11)
Local endothelial dna repair defect causes aging-resembling endothelial-specific dysfunction. (2020) (11)
Attenuated XPC Expression Is Not Associated with Impaired DNA Repair in Bladder Cancer (2015) (10)
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models. (2012) (10)
Genome (in)stability (2006) (10)
Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair. (2015) (9)
Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients (2020) (9)
DNA repair. Incisions for excision. (1994) (9)
Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging (2020) (9)
The genes for the variable surface glycoproteins of Trypanosoma brucei. (1980) (8)
Nucleotide Excision Repair (2004) (8)
High Preservation of CpG Cytosine Methylation Patterns at Imprinted Gene Loci in Liver and Brain of Aged Mice (2013) (6)
DNA damage-induced histone H 1 ubiquitylation is mediated by HUWE 1 and stimulates the RNF 8-RNF 168 pathway (2017) (6)
Kinetoplast DNA in the insect trypanosomes Crithidia luciliae and Crithidia fasciculata. III. Heteroduplex analysis of the C. luciliae minicircles. (1982) (6)
Different responses to DNA damage determine ageing differences between organs (2022) (6)
Pollitt syndrome patients carry mutation in TTDN1 (2014) (6)
MammalianCry 1 andCry 2 areessential formaintenance of circadian rhythms (1999) (5)
In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration (2021) (5)
DNA Repair: Nucleotide excision–repair in the test tube (1995) (5)
Deficiency of nucleotide excision repair explains mutational signature observed in cancer (2017) (4)
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC (2008) (4)
Chromatin Structure and Gene Expression During Spermatogenesis (1998) (4)
Molecular Genetic Dissection of Mammalian Excision Repair (1989) (4)
A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity. (2015) (4)
Molecular basis of DNA repair mechanisms and syndromes. (1998) (4)
Base editor repairs mutation found in the premature-ageing syndrome progeria (2021) (3)
Mechanisms of ageing in chronic allograft nephropathy (2007) (3)
O-001. Genes and infertility: from yeast to mouse and man (1999) (2)
Hybridocytochemistry with 2-acetylaminofluorene-modified probes. (1984) (2)
[Mutant mice as a model of human diseases of aging. Defective transcription and premature aging]. (1999) (2)
140 FASTING PROTECTS AGAINST HEPATIC ISCHEMIA-REPERFUSION INJURY VIA UPREGULATION OF HO-1 AND ANTIOXIDANT DEFENCE (2010) (2)
Genome instability and accelerated aging: The relevance for normal aging and life span extension (2006) (2)
Cloning of human repair genes by genomic DNA transfection. (1989) (2)
Cellular Concentrations of DDB 2 Regulate Dynamic Binding of DDB 1 at UV-Induced DNA Damage (2008) (2)
Molecular cloning of part of the human excision repair gene ercc 3 (1988) (2)
Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging (2013) (2)
DNA damage and repair: from premature aging and cancer to longevity (2008) (2)
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols (2013) (2)
Triple Check : Multi-Step DNA Lesion Identification by Nucleotide Excision Repair (2015) (2)
DNA double strand break repair: Zooming in on the focus (2009) (2)
The regulatory landscapes of human ovarian ageing (2022) (1)
Mechanisms of Cancer-related Cardiomyopathy67Protection against chemotherapy cardiotoxicity by the human amniotic fluid stem cell secretome: a new tool for future paracrine therapy68Hyperlipidaemia reduces mortality in breast, prostate, lung and bowel cancer69DNA-repair in cardiomyocytes is critical (2016) (1)
Abstract 1657: Mapping mechanisms of radiotherapy resistance in prostate cancer (2016) (1)
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC (2008) (1)
The Life Course of Femoral Shape in Mice (2011) (1)
Immunosuppression Acute Skin Effects and Systemic Repair Differentially Influence UV-B-Induced Transcription-Coupled and Global Genome (2011) (1)
In Vitro Correction of Cells from Patients with Mutagen Hypersensitivity (1989) (1)
Twisting mice move the dystonia field forward (2014) (1)
DNA repair and mutagenesis: edited by E.C. Friedberg, G.C. Walker and W. Siede ASM Press, 1995. £79.00 hbk (698 pages) ISBN 1 55581 088 8 (1996) (1)
The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside (2022) (1)
Abstract 4603: Targeted treatment of metastatic melanoma through interference with Pin1-FOXM1 signaling (2014) (1)
A Preoperative Protein-Free Diet Protect Against Hepatic Ischemia and Reperfusion Injury: 1886 (2012) (1)
Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene , ERCC 3 (1)
Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice (2022) (1)
12 DNA Repair and Aging (2008) (1)
Replication of damaged DNA (2001) (0)
185Repair of DNA damage induced by UV and γ-rays (1996) (0)
Accumulation of DNA damage is associated with loss of pluripotency upon culture expansion of human mesenchymal stem cells (2008) (0)
A Confocal Single Molecule Study of DNA Repair Complexes (2002) (0)
THE INTERPHASE BETWEEN DNA DAMAGE REPAIR AND TRANSCRIPTION (1996) (0)
Popular Books Similar With Molecular Basis Of Aging Are Listed (2017) (0)
Partial Characterization of Genes and Gene Products Involved in Excision Repair of Human Cells (1985) (0)
Single Molecule Confocal Fluorescence Microscopy of Nucleotide Excision Repair Complexes (2001) (0)
244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program (2017) (0)
A confocal fluorescence microscopy study of single molecule structure, dynamics and interaction (2003) (0)
The network segregation of the kinetoplast DNA (kDNA) in Trypanosoma brucei and Trypanosoma evansi. (1980) (0)
DNA-protein interactions: single molecule spectroscopy and imaging (1999) (0)
Genomiccharacterization ofthehumanDNA excision repair geneERCC-1 (1987) (0)
Conserved Pattern ofAntisense Overlapping Transcription inthe Homologous HumanERCC-IandYeastRADIODNA Repair GeneRegions (1989) (0)
The Effects of Pressure Overload on Cardiac Geometry and Function are Aggravated by Aging (2010) (0)
PL 6 DNA damage repair syndromes in man and mouse (1997) (0)
Neurodegeneration in accelerated ageing mouse models (2013) (0)
Aging Aggravates Cardiac Dysfunction in Severe, but not in Mild, Pressure‐Overload (2012) (0)
Tumor slice culture system to assess drug response of primary breast cancer (2016) (0)
439Exercise training fails to improve cardiac dysfunction in DNA-repair deficient Xpg mice (2018) (0)
DNA damage in pancreatic beta cells is connected with loss of cell mass and function in an ERCC1-deficient mouse model (2016) (0)
1: NEW ASPECTS OF CELL METABOLISM DURING IRI (2014) (0)
Premature aging of bone is delayed by dietary restriction (2014) (0)
Long-term probiotic intervention alters immune competence and gut barrier in fast ageing Ercc1-/ ¿7 mice (2014) (0)
Abstract 510: Dietary Restriction Improves Vasodilator Dysfunction Caused by Accelerated Vascular Aging Due to Genomic Instability (2013) (0)
Systemic Immunosuppression UV-B-Induced Acute Skin Effects and Repair Differentially Influence Transcription-Coupled and Global Genome (2000) (0)
Differential role of UVB-induced photolesions in skin and immune response. (50.10) (2011) (0)
Molecular and cellular basis of genome instability in cancer (1988) (0)
Role of miRNAs in DNA damage response: relevance for cancer and cancer therapy (2008) (0)
Induction ofamutant phenotype inhumanrepair proficient cells after overexpression ofamutated human DNArepair gene (1991) (0)
95th International Titisee Conference (2007) (0)
Diverse Effects of Aging on the Cardiac Response in Pathological Left Ventricular Remodeling and Dysfunction (2013) (0)
The DNA damage response to transcription stress (2019) (0)
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease (2018) (0)
Abstract 2425: Exploiting DNA repair defects in breast cancer (2014) (0)
Honderd jaar radiologie in Nederland. V. Radiotherapie, toekomstige ontwikkelingen. (1995) (0)
Altered MicroRNA Expression is Associated with the Protective Effect of Preoperative Dietary Restriction or Fasting After Renal Ischemia Reperfusion Injury: 354 (2012) (0)
Dna Repair Capacity Determines Age-Related Vascular Dysfunction: 5c.01 (2011) (0)
42 Deficiencies in DNA repair and its clinical impacts (1995) (0)
Establishment and Characterization of a Melanoma Cell Line from a Xeroderma Pigmentosum Patient: Activation of N-ras at a Potential Pyrimidine Dimer Site1 (2006) (0)
15 Cell Cycle Kinase Is Associated TFIIH Transcription-DNA Repair Facto (1994) (0)
Single Molecule Study of Nucleotide Excision Repair Complexes Using GFP Fusion Products (1999) (0)
Structure of the XPF-single strand DNA complex (2010) (0)
Solution structure of the F231L mutant ERCC1-XPF dimerization region (2015) (0)
Mouse models of premature aging aimed at defining the role of DNA damage caused by the aging and intervention in a disease related to aging. (2005) (0)
DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1 (2018) (0)
Direct Visualisation of Individual DNA Photolyase Interactions by Atomic Force Microscopy (1998) (0)
Establishment and Characterization of a Melanoma Cell Line from a Xeroderma Pigmentosum Patient : Activation of N-ras at a Potential Pyrimidine Dimer Site 1 (2006) (0)
Long-term probiotic intervention affects B cell differentiation in bone marrow of fast ageing Ercc1-/¿7 mice (2014) (0)
monoubiquitylation of histone H 2 A DNA damage triggers nucleotide excision repair-dependent data (2006) (0)
Reply to LT-11-401. (2011) (0)
Ercc1-/¿7 mice are a suitable model for ageing of mucosal immunity and microbiota (2014) (0)
Cloning and characterization of p 52 , the fifth subunit of the core of the transcription / DNA repair factor TFIIH experiments using normal and NER-deficient mammalian (2013) (0)
Abstract 2843: TASC1, a selective anti-senescence therapeutic which potently and selectively counteract resistance to chemo- and radiotherapy (2016) (0)
Differential modulation of cytokine production in DNA repair-deficient mice (2000) (0)
Meta Gene Pollitt syndrome patients carrymutation in TTDN 1 (2014) (0)
Abstract IA001: DNA damage repair: Impact on aging and cancer and applications of nutritional interventions (2023) (0)
Correction: Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice (2008) (0)
P499The effects of aging on pathologic left ventricular remodeling and dysfunction depend critically on the underlying pathology (2014) (0)
Rapid-aging Xpg-/- mice model age-related retinal inflammation (2018) (0)
68 Conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in mammals (1996) (0)
DNA damage and the cancer aging dilemma (2010) (0)
Accelerated bone aging in the trichothiodystrophy mouse model. (2003) (0)
Prematurely aging mice to demonstrate the role of DNA damage in aging and age-related pathology engagement in the (2005) (0)
Repair of Chromosomal Damage : Transcription-Coupled DNA Repair and Its Disorders(Symposium : Manipulating Chromosomes)(Abstracts of the 52nd Annual Meeting of the Society of Chromosome Research) (2001) (0)
DNA damage responses and chemosensitivity of breast cancer tissue slices ex vivo (2016) (0)
Erratum to “Sealing the gap between nuclear DNA damage and longevity” [Mol. Cell. Endocrinol. 299 (2009) 112–117] (2009) (0)
Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of XPF (2005) (0)
Structural and Functional Analysis of Mammalian Cryptochromes -A Matter of Time (2002) (0)
The effects of aging on the cardiac response to hemodynamic overload depend critically on the underlying pathology (2011) (0)
University of Groningen Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex Bergink, (2013) (0)
Abstract 20900: Exercise Training Fails to Improve Cardiac Dysfunction in DNA Repair-Deficient Xpg Mice (2017) (0)
S21 02 WA – GENES CONTROLLING DNA REPAIR IN MAMMALIAN CELLS (1991) (0)
Reply (2011) (0)
EMBO Member's review Cockayne syndrome: defective repair of transcription? (1997) (0)
The effect of long-term probiotic intervention in fast-aging Ercc1 -/Δ7 (2015) (0)
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice (2011) (0)
Additional Involvements of Nucleotide Excision Repair Enzymes: Key to Understanding the Symptoms of Inherited Repair Deficiency? (1996) (0)
Ercc1 Deficient Mice Show Segmental Progeria (2012) (0)
A bona fide model for age-related osteoporosis in accelerated aging trichothiodystrophy (TTD) mice (2010) (0)
Solution structure of the human homodimeric dna repair protein XPF (2006) (0)
Mammalian blue-light photoreceptor homologs CRY1 and CRY2 are involved in maintenance of circadian rhythms (1999) (0)
PROTECTION AGAINST RENAL ISCHEMIA INJURY IN DNA-REPAIR DEFICIENT COCKAYNE SYNDROME MICE: 855 (2008) (0)
Transcription-coupled Repair as a Biodefence Mechanism (1998) (0)
Single nucleotide excision repair complexes studied with confocal fluorescence microscopy (2001) (0)
Roles of recombination in DNA damage repair (2001) (0)
Enhanced Sensitivity of Csb m/m /Xpa −/− Retinal Photoreceptor Cells to Genotoxic Insults (2013) (0)
Confocal Fluorescence Microscopy on Single Nucleotide Excision Repair Complexes (2001) (0)
The physicochemical composition of osteoporotic bone in the TTD premature aging mouse determined by confocal Raman microscopy (2007) (0)
Epidemiology of Neisseria meningitidis: serogrouping and serotyping; a method for large-scale serotyping (1981) (0)
Additional file 6: Figure S6. of Tumor slice culture system to assess drug response of primary breast cancer (2016) (0)
Microarray Analysis After Preoperative Dietary Restriction Reveals Potential Mechanisms Involved in the Protection Against Ischemia-Reperfusion Injury.: Abstract# C1684 (2014) (0)
Microarray analysis after preoperative dietary restriction reveals potential mechanisms involved in the protection against renal ischemia-reperfusion injury (2014) (0)
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing (2012) (0)
Photochemically induced dynamic nuclear polarization in photosystem I observed by 13C magic-angle spinning NMR (2004) (0)
Abstract 3392: Ex vivo analysis of RAD51 foci induction in fresh tumor tissue: a promising new tool for the identification of homologous recombination-deficient tumors (2015) (0)
6 Nucleotide Species Excision-Repair Among (2005) (0)
Intact DNA Repair in Differentiated Cardiomyocytes is Essential for Maintaining Cardiac Function in Response to Physiological Stimulus (2019) (0)
Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity (2022) (0)
Microarray analysis of the response of the genome upon exposure to UV using genetically defined mouse models for DNA repair (2001) (0)
Recombining DNA Damage Repair, Basal Transcription, and Human Syndromes (1997) (0)
Validation Of Circulating MicroRnas As Biomarkers In Heart Failure In Two Large Independent Cohorts (2015) (0)
Dietary restriction extends lifespan more than two fold in Ercc1Δ/− mice (2013) (0)
[100 years of radiology in The Netherlands. V. Radiotherapy, future developments]. (1995) (0)
CALORIE RESTRICTION AND FASTING PROTECT AGAINST ACUTE OXIDATIVE DAMAGE INDUCED BY ISCHEMIC INJURY IN MICE: 1826 (2008) (0)
Isolation and Characterization of Genes Involved in Mammalian Excision Repair (1989) (0)
A Single Molecule Study on Nucleotide Excision Repair Complexes (2001) (0)
Single-molecule fluorescence microscopy on nucleotide excision repair complexes using GFP fusion proteins (2000) (0)
The mRAD18Sc/HR6B protein complex localizes to replication foci and UV induced DNA lesions (2003) (0)
Erratum: Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC (Journal of Cell Science (2008) vol. 121 (2850-2859)) (2008) (0)
DNA damage, repair, cancer and ageing in man and mice (2000) (0)
Trinucleotide repeat expansion and human cancer: the role of MSH3 and FEN-1 in unpaired DNA processing. (1999) (0)

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