Jan Nedergaard
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Jan Nedergaard's Degrees
- PhD Biology University of Copenhagen
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(Suggest an Edit or Addition)Jan Nedergaard's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Brown adipose tissue: function and physiological significance. (2004) (5408)
- Unexpected evidence for active brown adipose tissue in adult humans. (2007) (1749)
- Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes* (2009) (1226)
- UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. (2009) (1212)
- Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages (2007) (715)
- The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue (2009) (714)
- Nonshivering thermogenesis and its adequate measurement in metabolic studies (2011) (591)
- UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. (2001) (549)
- UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. (2013) (536)
- Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues. (2012) (512)
- A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. (2013) (500)
- The browning of white adipose tissue: some burning issues. (2014) (435)
- Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold (2001) (435)
- The changed metabolic world with human brown adipose tissue: therapeutic visions. (2010) (414)
- Genetic and functional characterization of clonally derived adult human brown adipocytes (2015) (371)
- Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent (2000) (328)
- Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. (2009) (317)
- Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation (2004) (312)
- The biochemistry of an inefficient tissue: brown adipose tissue. (1985) (308)
- Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis (2017) (268)
- UCP1 mRNA does not produce heat. (2013) (250)
- A stringent validation of mouse adipose tissue identity markers. (2015) (232)
- The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions (2003) (229)
- UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. (2006) (223)
- Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. (2009) (222)
- UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity (2010) (212)
- Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure (2014) (209)
- The brown fat cell. (1982) (209)
- Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. (1990) (196)
- Norepinephrine Induces Vascular Endothelial Growth Factor Gene Expression in Brown Adipocytes through a β-Adrenoreceptor/cAMP/Protein Kinase A Pathway Involving Src but Independently of Erk1/2* (2000) (193)
- Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via beta 1 but not via beta 3 adrenoceptors. (1992) (187)
- A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. (2005) (185)
- Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study (2017) (180)
- Uncoupling proteins: a role in protection against reactive oxygen species--or not? (2006) (180)
- Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans) (2010) (178)
- Three years with adult human brown adipose tissue (2010) (170)
- New powers of brown fat: fighting the metabolic syndrome. (2011) (170)
- PPARγ in the control of brown adipocyte differentiation (2005) (164)
- Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. (2004) (159)
- Exclusive occurrence of thermogenin antigen in brown adipose tissue (1982) (157)
- Distinct expression of muscle‐specific MicroRNAs (myomirs) in brown adipocytes (2009) (154)
- Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture. (1983) (152)
- UCP1 in adipose tissues: two steps to full browning. (2017) (148)
- Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist. (2008) (147)
- Native UCP1 Displays Simple Competitive Kinetics between the Regulators Purine Nucleotides and Fatty Acids* (2004) (145)
- Brown Adipose Tissue: More Than an Effector of Thermogenesis? a (1998) (133)
- Uncoupling proteins: current status and therapeutic prospects (2005) (133)
- Kinetics of the inhibition of mitochondrial respiration by NO (1997) (126)
- Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (2011) (119)
- Adipose tissue pathways involved in weight loss of cancer cachexia (2010) (118)
- Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor γ in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression (2012) (115)
- Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells. (1994) (115)
- Leptin Raises Defended Body Temperature without Activating Thermogenesis. (2016) (114)
- The Bioenergetics of Brown Fat Mitochondria from UCP1-ablated Mice (1999) (113)
- Cig30, a Mouse Member of a Novel Membrane Protein Gene Family, Is Involved in the Recruitment of Brown Adipose Tissue* (1997) (112)
- Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not? (2011) (110)
- Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool. (1992) (109)
- SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity (2005) (106)
- α1-Adrenergic Stimulation Potentiates the Thermogenic Action of β3-Adrenoreceptor-generated cAMP in Brown Fat Cells* (1997) (103)
- Microcalorimetry of isolated mammalian cells (1977) (103)
- β1 to β3 Switch in Control of Cyclic Adenosine Monophosphate during Brown Adipocyte Development Explains Distinct β-Adrenoceptor Subtype Mediation of Proliferation and Differentiation1. (1999) (102)
- Thermogenesis challenges the adipostat hypothesis for body-weight control (2009) (101)
- A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via alpha1-adrenoceptors and protein kinase C activation. (2002) (99)
- Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance (2016) (97)
- β3- and α1-Adrenergic Erk1/2 Activation Is Src- but Not Gi-mediated in Brown Adipocytes* (2000) (96)
- Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle. (2010) (96)
- PPARgamma in the control of brown adipocyte differentiation. (2005) (95)
- Overview--preparation and properties of mitochondria from different sources. (1979) (92)
- Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects. (2010) (91)
- Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent. (1996) (89)
- Beta-adrenergic stimulation of lipoprotein lipase in rat brown adipose tissue during acclimation to cold. (1984) (89)
- Thermogenin amount and activity in hamster brown fat mitochondria: effect of cold acclimation. (1987) (87)
- A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria. (1988) (87)
- Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively. (2006) (87)
- Mammalian hibernation. (1990) (86)
- Uncoupling protein-1 is not leaky. (2010) (85)
- UCP1 and Defense against Oxidative Stress (2006) (80)
- Brown adipose tissue as an anti‐obesity tissue in humans (2014) (80)
- 'Neuropeptide tyrosine' (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue. (1986) (79)
- Cidea improves the metabolic profile through expansion of adipose tissue (2015) (79)
- Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity. (1995) (79)
- Increased fatigue resistance linked to Ca2+‐stimulated mitochondrial biogenesis in muscle fibres of cold‐acclimated mice (2010) (77)
- The Expression of Subunit c Correlates with and Thus May Limit the Biosynthesis of the Mitochondrial F0F1-ATPase in Brown Adipose Tissue (*) (1995) (77)
- β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway (2017) (77)
- UCP1: The Original Uncoupling Protein—and Perhaps the Only One? New Perspectives on UCP1, UCP2, and UCP3 in the Light of the Bioenergetics of the UCP1-Ablated Mice (1999) (77)
- Chapter 17 The uncoupling protein thermogenin and mitochondrial thermogenesis (1992) (77)
- Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice (2019) (75)
- An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes. (2012) (75)
- Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine. (1989) (75)
- α1- and β1-Adrenoceptor Signaling Fully Compensates for β3-Adrenoceptor Deficiency in Brown Adipocyte Norepinephrine-Stimulated Glucose Uptake (2005) (73)
- The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue. (1986) (72)
- How brown is brown fat? It depends where you look (2013) (71)
- Developmental biology: Neither fat nor flesh (2008) (71)
- Thermogenesis in Brown Adipocytes Is Inhibited by Volatile Anesthetic Agents A Factor Contributing to Hypothermia in Infants? (1994) (70)
- Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes. (2000) (68)
- The uncoupling protein thermogenin during acclimation: indications for pretranslational control. (1994) (66)
- Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c‐Fo subunit P1 isoform (2008) (66)
- Thyroid hormones: igniting brown fat via the brain (2010) (66)
- Increased respiration in skeletal muscle mitochondria from cold-acclimated ducklings: uncoupling effects of free fatty acids. (1986) (65)
- Studies of thermogenesis and mitochondrial function in adipose tissues. (2008) (65)
- Cold adaptation in the rat: increased brown fat peroxisomal beta-oxidation relative to maximal mitochondrial oxidative capacity. (1980) (64)
- Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice. (2001) (64)
- Yes, even human brown fat is on fire! (2012) (63)
- Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice. (2017) (63)
- Catecholamine sensitivity in brown fat cells from cold-acclimated hamsters and rats. (1982) (62)
- Nonshivering thermogenesis protects against defective calcium handling in muscle (2008) (61)
- Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1 (2017) (61)
- Norepinephrine-stimulated fatty-acid release and oxygen consumption in isolated hamster brown-fat cells. Influence of buffers, albumin, insulin and mitochondrial inhibitors. (1979) (61)
- Quantitative differentiation of α- and β-adrenergic respiratory responses in isolated hamster brown fat cells: Evidence for the presence of an α1-adrenergic component (1983) (60)
- DNA synthesis in mouse brown adipose tissue is under β-adrenergic control☆ (1989) (59)
- Signal transduction in brown adipose tissue recruitment: noradrenaline and beyond. (1996) (59)
- Cultures of adipose precursor cells from brown adipose tissue and of clonal brown-adipocyte-like cell lines. (2001) (58)
- The β3-adrenergic receptor is dispensable for browning of adipose tissues. (2017) (58)
- Norepinephrine utilizes alpha 1- and beta-adrenoreceptors synergistically to maximally induce c-fos expression in brown adipocytes. (1994) (57)
- α- andβ-adrenergic control of thermogenin mRNA expression in brown adipose tissue (1986) (57)
- A Dual Component Analysis Explains the Distinctive Kinetics of cAMP Accumulation in Brown Adipocytes* (1999) (56)
- Thermogenesis is β3- but not β1-adrenergically mediated in rat brown fat cells, even after cold acclimation. (1998) (55)
- Mammalian Hibernation [and Discussion] (1990) (54)
- Brown adipose tissue as a heat-producing thermoeffector. (2018) (54)
- ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence. (2014) (53)
- The physiological role of pyruvate carboxylation in hamster brown adipose tissue. (1979) (52)
- Regulation of expression of the lipoprotein lipase gene in brown adipose tissue. (1992) (51)
- Down-regulation of β3 Adrenoreceptor Gene Expression in Brown Fat Cells Is Transient and Recovery Is Dependent upon a Short-lived Protein Factor* (1996) (51)
- Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture. (1987) (51)
- Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription. (1988) (51)
- ?- and ?-Adrenergic regulation of intracellular Ca levels in brown adipocytes (1989) (50)
- Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity (2018) (49)
- Halothane Selectively Inhibits Nonshivering Thermogenesis: Possible Implications for Thermoregulation during Anesthesia of Infants (1995) (49)
- Thermogenesis Inhibition in Brown Adipocytes Is a Specific Property of Volatile Anesthetics (2003) (49)
- No insulating effect of obesity. (2016) (48)
- Effects of dietary essential fatty acids on active thermogenin content in rat brown adipose tissue. (1983) (48)
- Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels (2004) (47)
- Physiological activation of brown adipose tissue destabilizes thermogenin mRNA (1987) (47)
- Cell biology: Neither brown nor white (2012) (46)
- [3H]GDP binding and thermogenin amount in brown adipose tissue mitochondria from cold-exposed rats. (1985) (45)
- Intact innervation is essential for diet-induced recruitment of brown adipose tissue (2018) (44)
- Cold‐induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption (2005) (44)
- Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells. (1998) (44)
- Sodium-induced calcium release from mitochondria in brown adipose tissue. (1979) (43)
- Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups. (1987) (43)
- Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism. (2008) (43)
- Na+-dependent, alpha-adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytes. (1984) (43)
- Postnatal recruitment of brown adipose tissue is induced by the cold stress experienced by the pups. An analysis of mRNA levels for thermogenin and lipoprotein lipase. (1989) (43)
- Norepinephrine as a morphogen?: its unique interaction with brown adipose tissue. (1995) (42)
- Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice. (2011) (42)
- beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation. (1999) (42)
- Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of beta(3)-adrenergic signalling rather than beta(3)-adrenoceptor antagonism by H89. (2001) (41)
- Differential role of presenilin‐1 and ‐2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts (2006) (41)
- Requirement of gene transcription and protein synthesis for cold- and norepinephrine-induced stimulation of thyroxine deiodinase in rat brown adipose tissue. (1986) (40)
- Modulation of calcium‐activated non‐selective cation channel activity by nitric oxide in rat brown adipose tissue. (1995) (40)
- Preferential utilization of brown adipose tissue lipids during arousal from hibernation in hamsters. (1984) (40)
- Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation? (1994) (39)
- An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes (2015) (39)
- Increased α1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters (1984) (38)
- Human mediastinal adipose tissue displays certain characteristics of brown fat (2013) (37)
- UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment. (2017) (37)
- Biochemical aspects of acclimation to cold (1983) (37)
- Norepinephrine‐induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture (1990) (37)
- PEROXISOMAL β‐OXIDATION IN BROWN FAT (1982) (36)
- The relationship between extramitochondrial Ca2+ concentration, respiratory rate, and membrane potential in mitochondria from brown adipose tissue of the rat. (1983) (36)
- Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues. (2014) (36)
- At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1 (2019) (35)
- The answer to the question “What is the best housing temperature to translate mouse experiments to humans?” is: thermoneutrality (2019) (35)
- Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes. (2000) (34)
- What Ignites UCP1? (2017) (34)
- Respiratory and thermogenic capacities of cells and mitochondria from brown and white adipose tissue. (2001) (33)
- Physiological desensitization of beta 3-adrenergic responses in brown fat cells: involvement of a postreceptor process. (1993) (33)
- ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes (2013) (32)
- In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain (2019) (32)
- Leptin: Is It Thermogenic? (2019) (32)
- Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of alpha 1-adrenergic stimulation. (1985) (31)
- Apparent unmasking of [3H]GDP binding in rat brown-fat mitochondria is due to mitochondrial swelling. (1987) (31)
- Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1. (2007) (30)
- Norepinephrine-induced Na+ influx in brown adipocytes is cyclic AMP-mediated. (1986) (30)
- alpha1-Adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells. (1997) (30)
- Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation. (1989) (30)
- Perinatal Activation of Brown Adipose Tissue (1988) (29)
- Thermogenesis is beta3- but not beta1-adrenergically mediated in rat brown fat cells, even after cold acclimation. (1998) (28)
- Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis. (2015) (28)
- Effects of cations on brown adipose tissue in relation to possible metabolic consequences of membrane depolarisation. (2005) (28)
- Cell proliferation and apoptosis inhibition: essential processes for recruitment of the full thermogenic capacity of brown adipose tissue. (2019) (28)
- Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria (2015) (28)
- Human brown adipose tissue: Classical brown rather than brite/beige? (2020) (28)
- NONSHIVERING THERMOGENESIS AND BROWN ADIPOSE TISSUE (1998) (27)
- Attenuation of Gs alpha coupling efficiency in brown-adipose-tissue plasma membranes from cold-acclimated hamsters. (1993) (27)
- Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling. (2010) (26)
- Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes (2000) (26)
- Distinction between mechanisms underlying alpha 1- and beta-adrenergic respiratory stimulation in brown fat cells. (1987) (26)
- Adrenergic stimulation of lipoprotein lipase gene expression in rat brown adipocytes differentiated in culture: mediation via beta3- and alpha1-adrenergic receptors. (1997) (26)
- Glucocorticoids and Brown adipose tissue: Do glucocorticoids really inhibit thermogenesis? (2019) (26)
- Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation. (2004) (25)
- Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake. (2005) (25)
- Beta-adrenergic stimulation of fatty acid release from brown fat cells differentiated in monolayer culture. (1986) (24)
- Glucocorticoid-Induced Obesity Develops Independently of UCP1. (2019) (24)
- Differential regulation of the expression of alpha1-adrenergic receptor subtype genes in brown adipose tissue. (1997) (24)
- Parallel increases in amount of (3H)GDP binding and thermogenin antigen in brown-adipose-tissue mitochondria of cafeteria-fed rats. (1984) (23)
- Alpha-adrenergic effects on 86Rb+ (K+) potentials and fluxes in brown fat cells. (1984) (22)
- Increased alpha 1-adrenoceptor density in brown adipose tissue indicates recruitment drive in hypothyroid rats. (1992) (22)
- PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte. (2010) (22)
- Brown adipose tissue: development and function (1998) (22)
- Brown adipose tissue thermogenesis in neonatal and cold-adapted animals. (1986) (22)
- THE BIOCHEMICAL MECHANISM OF THERMOGENESIS IN BROWN ADIPOSE TISSUE (1978) (22)
- Norepinephrine specifically stimulates ribonucleotide reductase subunit R2 gene expression in proliferating brown adipocytes: mediation via a cAMP/PKA pathway involving Src and Erk1/2 kinases. (2002) (21)
- Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes. (2010) (20)
- Na+-dependent regulation of extramitochondrial Ca2+ by rat-liver mitochondria. (1984) (20)
- Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes. (2005) (20)
- Carteolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes. (1998) (20)
- Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment. (1996) (19)
- Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels. (2004) (19)
- Brown adipose tissue: molecular mechanisms controlling activity and thermogenesis (1985) (18)
- The Interaction between Thyroid and Brown‐Fat Thermogenesis (1997) (18)
- Cold acclimation-recruited nonshivering thermogenesis: the Syrian hamster is not an exception. (1995) (18)
- Adenosine 5?-Monophosphate Is a Selective Inhibitor of the Brown Adipocyte Nonselective Cation Channel (2002) (18)
- Adrenergic regulation of brown adipocyte differentiation. (1996) (17)
- The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake. (2015) (17)
- Effects of monovalent cations on Ca2 transport in mitochondria; a comparison between brown fat and liver mitochondria from rat. (1980) (17)
- Uncoupling protein-1: involvement in a novel pathway for beta-adrenergic, cAMP-mediated intestinal relaxation. (2002) (16)
- Alpha 1- and beta-adrenergic regulation of intracellular Ca2+ levels in brown adipocytes. (1989) (16)
- Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes. (2008) (16)
- DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control. (1989) (15)
- Beta-adrenergic modulation of Ca2+ uptake by isolated brown adipocytes. Possible involvement of mitochondria. (1988) (15)
- Regulation of the Activity of 27 pS Nonselective Cation Channels in Excised Membrane Patches from Rat Brown-Fat Cells (1998) (15)
- Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA. (1985) (14)
- Metabolic consequences of limited substrate anion permeability in brown fat mitochondria from a hibernator, the golden hamster. (1984) (14)
- Benidipine induces thermogenesis in brown adipose tissue by releasing endogenous noradrenaline: a possible mechanism for the anti-obesity effect of calcium antagonists (1999) (14)
- Effects of cholera toxin on gene expression in brown preadipocytes differentiating in culture. (1989) (14)
- Protein kinase a-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR. (2014) (14)
- NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat. (1989) (14)
- As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor. (2001) (14)
- Cold acclimation induces desensitization to adenosine in brown fat cells without changing receptor binding. (1990) (14)
- Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice (2015) (13)
- Shivering and Nonshivering Thermogenesis in Birds: A Mammalian View (1989) (13)
- Regulation of thermogenic capacity in brown and white adipocytes by the prebiotic high-esterified pectin and its postbiotic acetate (2019) (13)
- Comparison of the pharmacological profiles of adrenergic drugs (including BRL-agonists) at [3H]prazosin and [3H]CGP-12177 binding sites in brown adipose tissue. (1989) (13)
- Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice. (1997) (13)
- The Role of Adrenergic Stimulation in Regulation of Heat Production and Recruitment of Brown Adipose Tissue (1994) (12)
- Cig30 and Pitx3 Genes Are Arranged in a Partially Overlapping Tail-to-Tail Array Resulting in Complementary Transcripts* (1999) (12)
- Leptin-deficient mice are not hypothermic, they are anapyrexic (2016) (12)
- α1‐Adrenergic stimulation of Cl− efflux in isolated brown adipocytes (1990) (12)
- Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness. (2010) (12)
- Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes. (2001) (12)
- Is there a Life in the Cold without UCP1? Uncoupling Proteins and Thermoregulatory Thermogenesis (2000) (12)
- A possible physiological role of the Na+/Ca2+ exchange mechanism of brown-fat mitochondria in the mediation of alpha 1-adrenergic signals. (1984) (11)
- Reversible blockade of the calcium-activated nonselective cation channel in brown fat cells by the sulfhydryl reagents mercury and thimerosal (1993) (11)
- Alpha 1-adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent. (1987) (11)
- Enzyme-linked immunosorbent assay (ELISA) studies of the interaction between mammalian and avian anti-thermogenin antibodies and brown-adipose-tissue mitochondria from different species. (1984) (11)
- Sulfonates are low-affinity ligands for the GDP-binding site of brown-fat mitochondria. (1994) (11)
- Effect of transforming growth factor-β on calcium homeostasis in prostate carcinoma cells (2003) (11)
- Biochemical Mechanisms of Thermogenesis (1985) (10)
- Increased α1 receptor density in brown adipose tissue of cafeteria-fed rats (1984) (10)
- Energy dissipation in brown fat. (1978) (10)
- Nonselective cation channels in brown and white fat cells. (1993) (10)
- Stimulation of nonshivering thermogenesis in the Syrian hamster by norepinephrine and beta-selective adrenergic agents: a phenomenon of refractoriness. (1996) (9)
- In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation. (2013) (9)
- Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells. (2003) (9)
- Norepinephrine-induced sustained inward current in brown fat cells: alpha(1)-mediated by nonselective cation channels. (2000) (9)
- A pyrexic effect of FGF21 independent of energy expenditure and UCP1 (2021) (9)
- Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum. (1996) (9)
- Only UCP 1 can mediate adaptive nonshivering thermogenesis in the cold 1 (2001) (8)
- Ca(2+) -independent effects of BAPTA and EGTA on single-channel Cl(-) currents in brown adipocytes. (2007) (8)
- Chapter 10 Thermogenic mitochondria (1984) (7)
- Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels. (2007) (7)
- Cold-induced changes in Ca2+ transport in duckling skeletal muscle mitochondria. (1987) (7)
- Chloride channels in brown adipocyte plasma membranes: candidates for mediation of alpha 1-adrenergic depolarization? (1995) (7)
- UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia (2019) (6)
- A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA. (2008) (6)
- Reply to ‘Confounding issues in the ‘humanized’ brown fat of mice’ (2020) (6)
- Thermogenic recruitment of brown and brite/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition (2020) (6)
- No insulating effect of obesity, neither in mice nor in humans. (2019) (5)
- Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes (2019) (5)
- PHYSIOLOGICAL UNCOUPLING IN BROWN FAT MITOCHONDRIA (1981) (5)
- alpha- and beta-adrenergic control of thermogenin mRNA expression in brown adipose tissue. (1986) (5)
- Peroxisomal beta-oxidation in brown fat. (1982) (5)
- Effects of guanine nucleotides and cations on agonist affinity of alpha 1-adrenoceptors in brown adipose tissue. (1985) (5)
- Quantitative differentiation of alpha- and beta-adrenergic respiratory responses in isolated hamster brown fat cells: evidence for the presence of an alpha 1-adrenergic component. (1983) (5)
- AN ATTEMPT TO DIFFERENTIATE BETWEEN α- AND β-ADRENERGIC RESPIRATORY RESPONSES IN HAMSTER BROWN FAT CELLS (1981) (5)
- Differential regulation of the gene expression of beta-adrenoceptor subtypes in brown adipocytes (1999) (5)
- Regulation of the Amount and Activity of the Uncoupling Protein Thermogenin in Brown Adipose Tissue (1989) (4)
- Partial protection against erucoyl-carnitine inhibition in hamster brown-adipose-tissue mitochondria is due to high CoA levels: a comparison with rat brown-adipose-tissue mitochondria. (1986) (4)
- Analysis of the Cellular Mechanism for Halothane Inhibition of Brown Adipose Tissue Thermogenesis (1997) (3)
- Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue (2016) (3)
- Reply to letter to the editor: at thermoneutrality, neither the lean nor the obese freeze. (2016) (3)
- Norepinephrine-induced proliferation of brown fat cell precursors. (1994) (3)
- Establishing the potency of N-acyl amino acids versus conventional fatty acids as thermogenic uncouplers in cells and mitochondria from different tissues. (2022) (2)
- Identifying novel genes involved in cAMP- induced cell proliferation of brown preadi- pocytes (2013) (2)
- Author Correction: Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice (2019) (2)
- Increased alpha 1-adrenergic receptor density in brown adipose tissue of cafeteria-fed rats. (1984) (2)
- Chapter 41 – Brown Adipose Tissue: Development and Function (2004) (2)
- Adipose tissues: The brown, the white and the brite (2015) (2)
- β3-adremergic regulation of hamster brown adipocyte thermogenesis (1990) (2)
- On the Validity of Adipogenic Cell Lines as Model Systems for Browning Processes: In Authentic Brown, Brite/Beige, and White Preadipocytes, There is No Cell-Autonomous Thermogenic Recruitment by Green Tea Compounds (2021) (2)
- Increased alpha 1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters. (1984) (2)
- Diet-Induced Thermogenesis: Principles and Pitfalls. (2022) (2)
- Mobilization of Ca2+ in brown adipocytes in response to alpha-adrenergic stimulation: Dependence on extracellular Na+ ions (1984) (2)
- Brown adipose tissue function and premature ageing: Impaired thermogenesis in mice expressing defective mitochondrial DNA polymerase (2012) (2)
- Brown Adipose Tissue: A Seasonal Tissue in Mammals, Including Humans? (2012) (2)
- Cell Metabolism Previews What Ignites UCP 1 ? (2)
- Demonstration of the existence of Ca2+-dependent K+ channels in isolated brown adipocytes (1984) (1)
- Pharmacology and Regulation of the Ion Channels of the Brown Adipocyte Plasma Membrane (1994) (1)
- PEROXISOMES IN BROWN FAT (1981) (1)
- Repeated short excursions from thermoneutrality suffice to restructure brown adipose tissue. (2023) (1)
- adipocytes reveals depot-selective binding correlated with gene expression 2 (2012) (1)
- Brown adipose tissue and non-shivering thermogenesis (1978) (1)
- Caveolin-1-ablated mice survive cold by nonshivering thermogenesis, despite desensitized adrenergic receptors (2010) (1)
- Expression of Zinc finger of the cerebellum 1 suggests a possible role in development and/or function of brown adipose tissue (2012) (1)
- Cold-induced proliferation of brown fat peroxisomes (1981) (1)
- Switch in cross-talk of beta and alpha-1 adrenoceptors in cultured brown fat cells (1996) (1)
- MITCHELL MEDAL LECTURE (2006) (1)
- Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes (2018) (1)
- Distinct from Classic Brown Adipocytes UCP1-containing Adipocytes Molecularly Thermogenically Competent, Cultures Reveals a Population of Epididymally Derived White Adipocyte ) Activation of γ (PPAR γ Receptor Chronic Peroxisome Proliferator-activated (2014) (1)
- Life without UCP1 (2001) (1)
- A polar development. The Runnström tradition in Swedish developmental biology. (1995) (1)
- Leptin as an Antitorpor Hormone: An Explanation for the Increased Metabolic Efficiency and Cold Sensitivity of ob/ob Mice? (2022) (1)
- SWITCH IN CROSS-TALK OF β & α1 ADRENOCEPTORS IN CULTURED BROWN FAT CELLS (1996) (1)
- b 1 to b 3 Switch in Control of Cyclic Adenosine Monophosphate during Brown Adipocyte Development Explains Distinct b -Adrenoceptor Subtype Mediation of Proliferation and Differentiation* (1999) (1)
- A PERKy way to make mitochondrial cristae (2021) (1)
- Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells. (1998) (1)
- Mitochondrial respiratory states and rates: building blocks of mitochondrial physiology (2018) (1)
- Thermogenic effect of ACYL-CoA in brown fat (1981) (1)
- No nonshivering thermogenesis in mice lacking UCP1, despite high UCP2 expression (2000) (1)
- A POSSIBLE METABOLIC EFFECT OF MEMBRANE DEPOLARISATION IN BROWN ADIPOSE TISSUE (1981) (1)
- Metabolic and angiogenic consequences of the presence or absence of UCP1 (2010) (1)
- Glyoxysome Biogenesis - General Discussion (1982) (1)
- Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice (2019) (0)
- Mitochondrial dynamics regulate brown adiopcyte energy expenditure (2013) (0)
- RIBONUCLEOTIDE REDUCTASE GENE EXPRESSION IN MOUSE BROWN ADIPOSE TISSUE (1996) (0)
- Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria (2015) (0)
- brown and ''brite'' but not white adipocytes An essential role for Tbx15 in the differentiation of (2013) (0)
- human skeletal muscle reactive oxygen species in isolated mitochondria from Ultraendurance exercise increases the production of (2015) (0)
- Brown adipocyte activation is characterized by a wave of mitochondrial fission and depolarization that is dependent on β3 receptor stimulation and Drp1, and is characterized by complete, but reversible, arrest of fusion (2011) (0)
- Cardiolipin: Altered content and fatty acid composition in mitochondria from mtDNA mutator mice (2010) (0)
- S14.6 Impaired thermogenesis in PolgA mtDNA polymerase mutant mice (2008) (0)
- INHIBITION OF BROWN FAT HEAT PRODUCTION BY INHALATION ANESTHETIC AGENTS (1991) (0)
- channels -mediated by nonselective cation 1 α brown fat cells: Norepinephrine-induced sustained inward current in (2016) (0)
- Brown adipose tissue: A neuroendocrine target (2018) (0)
- S3/5 Control and effect of UCP1 activity in brown-fat cells and mitochondria, and in mice and men (2008) (0)
- Mild uncoupling to counteract ROS production : Physiologically relevant or not? (2012) (0)
- Indirect Calorimetry in Rodent Models : Application to Studies of the Metabolic Syndrome (2012) (0)
- Enhanced ROS production in mitochondria from prematurely aging mtDNA mutator mice (2018) (0)
- Utilization of fetal and newborn serum to uncover novel regulators of subcutaneous adipocyte differentiation (2017) (0)
- A Ca-independent ?-adrener gically stimulated CL efflux over the cell membrane (1990) (0)
- PPARa is not involved in the regulation of muscle-associated genesin brown adipose tissue. (2010) (0)
- Corrections (1982) (0)
- Brown Adipose Tissue as a Target (2014) (0)
- Physiological effects on gene expression of some brown adipose tissue secreted factors (2014) (0)
- Brown Adipose Tissue: Receptors and Recruitment (1994) (0)
- No adaptive adrenergic thermogenesis can be induced without UCP1 Neither by cold nor by diet (2001) (0)
- Cationic regulation of brown adipose tissue metabolism (1981) (0)
- Apparent inhibition of Ca2+ uptake in brown adipocytes after β-adrenergic stimulation (1988) (0)
- Novel thiazolidinediones distinguish between (UCP1-independent) antidiabetic effects (MSDC-0602) and adipogenic and browning-inducing effects (MSDC-0160) of classical thiazolidinediones (rosiglitazone) (2015) (0)
- Editorial Board (2010) (0)
- Diet-induced thermogenesis and brown adipose tissue (2012) (0)
- Control of UCP1 activity in brown-fat mitochondria (2018) (0)
- S14.4 Random mtDNA mutations cause respiratory dysfunction through failure in complex assembly (2008) (0)
- Why are Brown-Fat Cells from Cold-Acclimated Animals Not Better? (2019) (0)
- influences on muscle function and insulin sensitivity regulation by exercise training and its α PGC-1 (2010) (0)
- Cl‐ Efflux in Brown Adipocytes A Possible Mechanism for α‐Adrenergic Plasma Membrane Depolarization (1989) (0)
- Effect of novel thiazolidinadiones on expression of UCP1 and mitochondrial respiratory chain proteins in brown and white adipose tissues (2012) (0)
- UCP1 and mitochondrial uncoupling (2010) (0)
- 80 Impaired function of mitochondria in tissues from mice expressing defective mitochondrial DNA polymerase (2010) (0)
- Lipid metabolism in the brown adipose tissue of the hibernating and the cold acclimated hamster (1989) (0)
- S5/1 Control of the synthesis of uncoupling and coupling proteins in brown adipose tissue (2008) (0)
- Choline+ is a low-affinity ligand for alpha 1-adrenoceptors. (1994) (0)
- Thermogenically competent recruitment of uncoupling protein 1 in brown preadipocytes and in a subset of cell precursors from epididymal white adipose tissue by a PPARγ agonist (2010) (0)
- Genes in the Cold: A Survey of the Regulation of Gene Expression in Brown Adipose Tissue (2019) (0)
- Quantification of de novo lipogenesis by room calorimetry (2012) (0)
- cAMP-stimulated cell proliferation in brown preadipocytes is mediated by protein kinase A, but is independent of ERK1/2, PI3K and mTOR (2013) (0)
- Highly recruited brown adipose tissue does not in itself protect against obesity (2017) (0)
- Choline+ is a low-affinity ligand for α1-adrenoceptors (1994) (0)
- Editorial Board (2007) (0)
- In primary brown adipose cultures, fetal and newborn bovine sera differently affect triglyceride storage and thermocompetence (2017) (0)
- Browning of adipose tissue and metabolic regulation (2017) (0)
- Cyclic-AMP-mediated Na+ ion influx in norepinephrine-stimulated brown adipocytes (1988) (0)
- Conspicuous improvement of health and life-span in mtDNA mutator mice treated with mitochondrially targeted antioxidant (2016) (0)
- CONTROL BY EXTRAMITOCHONDRIAL Na+ OF EXTRA-MITOCHONDRIAL Ca++ LEVELS: A POSSIBLE MECHANISM FOR HORMONAL EFFECTS IN LIVER (1981) (0)
- PFOA modulates activity and gene and protein expressions of UCP1 in brown adipocytes (2018) (0)
- Diagnostik I (2011) (0)
- PPAR α does not suppress muscle-associated gene expression in brown adipocytes (2010) (0)
- The significance of thermogenesis for the ageing process (2010) (0)
- EFFECT OF SHORT- AND LONG-TERM ADRENERGIC STIMULATION ON THE EXPRESSION OF THE UNCOUPLING PROTEIN THERMOGENIN (UCP) IN BROWN ADIPOCYTE PRECURSOR CELLS DIFFERENTIATING IN CULTURE (1996) (0)
- Molecular signatures of brown, white and brite adipose tissues. (2010) (0)
- Reply to ‘Confounding issues in the ‘humanized’ brown fat of mice’ (2020) (0)
- On adequate procedures for glucose tolerance tests in obese animals : Measurement of glucose tolerance in obesity (2015) (0)
- NONSHIVERING THERMOGENESIS -THROUGH UCP1 OR ALSO THROUGH OTHER MEANS? (2020) (0)
- Six Years with Adult Human Brown Adipose Tissue and Many More to Come (2014) (0)
- adrenergic responsiveness nonshivering thermogenesis despite desensitized Caveolin-1-ablated mice survive in cold by (2010) (0)
- Evidence for the expression of endothelin ETA receptors in mouse brown adipocytes. (1996) (0)
- A partial secretome of brown adipose tissue (2014) (0)
- Brown adipose tissue in physiologically humanized mice phenocopies human brown fat (2017) (0)
- Genetic and functional characterization of clonally derived adult human brown (2015) (0)
- Candidate Genes involved in cAMP-stimulated cell proliferation of brown preadipocytes (2012) (0)
- 300-LB: FGF21 and a ß3-Adrenergic Agonist Synergistically Lower Blood Glucose in Obese Mice at Thermoneutrality (2019) (0)
- Metabolite and ion fluxes and ion channels in brown and white adipocytes. (2001) (0)
- Uncoupling proteins : current status and therapeutic prospects Meeting on Uncoupling Proteins (2013) (0)
- Assessing energy demand in living organisms: the influence of environmental temperature (2014) (0)
- The significance of UCP1 in brown and brite/beige adipose tissues for the metabolic and body temperature effects of thyroid hormone, food, and leptin (2016) (0)
- S10.25 Effect of targeted quinones on ROS production and lipid peroxidation in mitochondria: Mitochondrial DNA polymerase mutant mice exibit high sensitivity (2008) (0)
- Immunological determination of thermogenin content in brown adipose tissue validation of the method (1989) (0)
- Editorial Board (1992) (0)
- At thermoneutrality, medium-chain fatty acids totally protect against diet-induced obesity in a UCP1-independent manner (2017) (0)
- Competent non-adrenergic recruitment of brown adipocytes by PPARgamma agonist is associated with dominant conversion of PPARgamma to a novel isoform (2007) (0)
- 3 Does the Presence / Absence of UCP 1 Affect Adaptive Nonshivering Thermogenesis ? (2010) (0)
- UPREGULATED CYTOCHROME B5 MAY RESCUE NORMAL ANDROGEN PRODUCTION IN MITOCHONDRIAL RESPIRATORY CHAIN-DEFICIENT LEYDIG CELLS FROM PREMATURELY AGING MICE (2015) (0)
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