Jan Steyaert
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Belgian bioengineer and molecular biologist
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Jan Steyaertbiology Degrees
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Molecular Biology
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Jan Steyaertengineering Degrees
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Biology Engineering
Jan Steyaert's Degrees
- PhD Bioengineering Ghent University
- Masters Molecular Biology Ghent University
- Bachelors Biotechnology Ghent University
Why Is Jan Steyaert Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jan Steyaert is a Belgian bioengineer and molecular biologist. He started his career as an enzymologist but the Steyaertlab is best known for pioneering work on nanobodies for applications in structural biology, omics and drug design. He is full professor and teaches biochemistry at the Vrije Universiteit Brussel and Director of the VIB-VUB Center for Structural Biology, one of the Research Centers of the Vlaams Instituut voor Biotechnologie . He was involved in the foundation of three spin-off companies: Ablynx, Biotalys, and Confo Therapeutics.
Jan Steyaert's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Crystal Structure of the β2Adrenergic Receptor-Gs protein complex (2011) (2589)
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor (2010) (1516)
- Activation and allosteric modulation of a muscarinic acetylcholine receptor (2013) (773)
- Conformational biosensors reveal GPCR signalling from endosomes (2013) (692)
- Structural insights into μ-opioid receptor activation (2015) (653)
- A general protocol for the generation of Nanobodies for structural biology (2014) (491)
- GABAA receptor signalling mechanisms revealed by structural pharmacology (2019) (304)
- Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis (2017) (248)
- Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor (2018) (247)
- Nanobody stabilization of G protein-coupled receptor conformational states. (2011) (220)
- Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain (2013) (212)
- Propagation of conformational changes during μ-opioid receptor activation (2015) (205)
- Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer (2019) (203)
- Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation (2016) (200)
- The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase. (1993) (199)
- Allosteric coupling from G protein to the agonist binding pocket in GPCRs (2016) (198)
- A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action (2018) (192)
- Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system. (2005) (190)
- Influence of the π–π interaction on the hydrogen bonding capacity of stacked DNA/RNA bases (2005) (189)
- Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes (2015) (185)
- Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody. (2009) (177)
- Structural flexibility of the Gαs α-helical domain in the β2-adrenoceptor Gs complex (2011) (170)
- Nanobodies to Study G Protein-Coupled Receptor Structure and Function. (2017) (166)
- Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport (2014) (157)
- The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier (2019) (155)
- Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. (2010) (148)
- Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family (2015) (141)
- Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling (2018) (133)
- Structural basis for GABAA receptor potentiation by neurosteroids (2017) (124)
- SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly (2012) (124)
- Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11 (2014) (123)
- Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant (2011) (114)
- Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies (2014) (113)
- GABAA receptor signalling mechanisms revealed by structural pharmacology (2019) (112)
- Characterization of Phenylpyruvate Decarboxylase, Involved in Auxin Production of Azospirillum brasilense (2007) (112)
- Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (2018) (109)
- Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex (2019) (99)
- Histidine-40 of ribonuclease T1 acts as base catalyst when the true catalytic base, glutamic acid-58, is replaced by alanine. (1990) (98)
- Structural Insights into Metabotropic Glutamate Receptor Activation (2018) (98)
- Catalysis by nucleoside hydrolases. (2003) (95)
- reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. (2016) (94)
- Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody. (2014) (93)
- Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System (2011) (92)
- A decade of protein engineering on ribonuclease T1--atomic dissection of the enzyme-substrate interactions. (1997) (89)
- Structure of PINK1 in complex with its substrate ubiquitin (2017) (89)
- Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax. (2001) (88)
- Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities. (2016) (86)
- Structures of influenza A virus RNA polymerase offer insight into viral genome replication (2019) (82)
- Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. (2013) (82)
- Structural insights into the activation of metabotropic glutamate receptors (2019) (81)
- Assessment of stability, toxicity and immunogenicity of new polymeric nanoreactors for use in enzyme replacement therapy of MNGIE. (2009) (80)
- Structure of a bacterial type IV secretion core complex at subnanometre resolution (2013) (79)
- An Intrabody Based on a Llama Single-domain Antibody Targeting the N-terminal α-Helical Multimerization Domain of HIV-1 Rev Prevents Viral Production* (2010) (77)
- Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus. (2009) (77)
- Nanobody-enabled monitoring of kappa opioid receptor states (2020) (71)
- Leaving group activation by aromatic stacking: an alternative to general acid catalysis. (2004) (71)
- Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes (2015) (71)
- Structure of the human alpha1beta3gamma2 GABA-A receptor in a lipid bilayer (2019) (67)
- Characterization of two homologous 2′-O-methyltransferases showing different specificities for their tRNA substrates (2014) (66)
- Isolation of antigen-binding camelid heavy chain antibody fragments (nanobodies) from an immune library displayed on the surface of Pichia pastoris. (2010) (64)
- Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. (1989) (60)
- Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor (2018) (59)
- A llama-derived gelsolin single-domain antibody blocks gelsolin–G-actin interaction (2010) (59)
- Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM (2019) (57)
- BRET evidence that β2 adrenergic receptors do not oligomerize in cells (2015) (56)
- Crystal structure determination and refinement at 2.3-A resolution of the lentil lectin. (1993) (50)
- An improved yeast surface display platform for the screening of nanobody immune libraries (2019) (49)
- Conserved water molecules in a large family of microbial ribonucleases (1999) (47)
- Enzyme-Substrate Interactions in the Purine-specific Nucleoside Hydrolase from Trypanosoma vivax* (2002) (44)
- Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor (2016) (44)
- L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction (2019) (44)
- Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes. (2016) (43)
- The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism (2019) (41)
- Nanobodies to study protein conformational states. (2020) (38)
- Crystal structure of a LacY–nanobody complex in a periplasmic-open conformation (2016) (37)
- Quantitative analysis of the contribution of Glu46 and Asn98 to the guanosine specificity of ribonuclease T1. (1991) (36)
- Influenza A virus RNA polymerase structures provide insights into viral genome replication (2019) (36)
- A lipid site shapes the agonist response of a pentameric ligand-gated ion channel (2019) (35)
- Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport. (2017) (35)
- Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. (2017) (35)
- The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 Å resolution (2007) (35)
- Dissection of the structural and functional role of a conserved hydration site in RNase T1 (2008) (35)
- Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis. (2006) (34)
- Analysis of a water mediated protein-protein interactions within RNase T1. (2000) (34)
- Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1. (2019) (33)
- Evaluation of Nucleoside Hydrolase Inhibitors for Treatment of African Trypanosomiasis (2010) (33)
- Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors. (2018) (33)
- Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. (2011) (33)
- Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands. (2018) (32)
- Molecular Mechanism of Allosteric Substrate Activation in a Thiamine Diphosphate-dependent Decarboxylase* (2007) (31)
- Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody (2011) (30)
- Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli. (2013) (30)
- Deciphering the mechanism of RNase T1. (2001) (30)
- Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallograph (1998) (30)
- Recombinant Human Prion Protein Inhibits Prion Propagation in vitro (2013) (29)
- N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase. (2008) (29)
- Primary structure and partial characterization of a life-cycle-regulated cysteine protease from Trypanosoma (Nannomonas) congolense. (1995) (29)
- A novel expression system for production of soluble prion proteins in E. coli (2012) (29)
- Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non‐chemokine agonists (2018) (28)
- Ribonucleases: from prototypes to therapeutic targets? (2003) (28)
- Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. (2010) (27)
- Crystal Structure of a ligand-bound LacY–Nanobody Complex (2018) (27)
- Mechanism of RNase T1: concerted triester-like phosphoryl transfer via a catalytic three-centered hydrogen bond. (2000) (26)
- Functional interactions among the His40, Glu58 and His92 catalysts of ribonuclease T1 as studied by double and triple mutants. (1993) (26)
- Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody. (2013) (26)
- DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops (2016) (26)
- Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules. (2005) (26)
- Domain-interface dynamics of CFTR revealed by stabilizing nanobodies (2019) (25)
- Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones. (2013) (25)
- New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product. (2006) (24)
- Substrate-assisted Leaving Group Activation in Enzyme-catalyzed N-Glycosidic Bond Cleavage* (2005) (24)
- Hydrogen-exchange stabilities of RNase T1 and variants with buried and solvent-exposed Ala --> Gly mutations in the helix. (1999) (24)
- Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody Abskharon, (2014) (23)
- SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization (2014) (23)
- Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity (2019) (23)
- Subsite interactions of ribonuclease T1: Asn36 and Asn98 accelerate GpN transesterification through interactions with the leaving nucleoside N. (1991) (23)
- Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. (2009) (22)
- Structural insights into the activation of metabotropic glutamate receptors (2019) (22)
- Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody (2017) (22)
- Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies (2020) (22)
- Outward-facing conformers of LacY stabilized by nanobodies (2014) (22)
- A Flexible Loop as a Functional Element in the Catalytic Mechanism of Nucleoside Hydrolase from Trypanosoma vivax* (2008) (21)
- Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors. (2008) (21)
- Nanobody Mediated Crystallization of an Archeal Mechanosensitive Channel (2013) (21)
- Heteromeric GABAA receptor structures in positively-modulated active states (2018) (21)
- Transient conformers of LacY are trapped by nanobodies (2015) (20)
- Subsite interactions of ribonuclease T1: viscosity effects indicate that the rate-limiting step of GpN transesterification depends on the nature of N. (1991) (20)
- Cloning, preliminary characterization and crystallization of nucleoside hydrolases from Caenorhabditis elegans and Campylobacter jejuni. (2003) (20)
- Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor (2022) (18)
- Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes. (2011) (18)
- A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo (2017) (18)
- Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein. (2019) (18)
- The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools. (2016) (17)
- Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion (2019) (17)
- Substrate-dependent modulation of enzyme activity by allosteric effector antibodies. (2009) (17)
- The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2 (2012) (17)
- Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax (2019) (17)
- Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression. (2016) (16)
- Purification, circular dichroism analysis, crystallization and preliminary X-ray diffraction analysis of the F plasmid CcdB killer protein. (1993) (16)
- Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei. (2010) (16)
- Synthesis of Bicyclic N‐Arylmethyl‐Substituted Iminoribitol Derivatives as Selective Nucleoside Hydrolase Inhibitors (2009) (16)
- Pre-steady-state analysis of the nucleoside hydrolase of Trypanosoma vivax. Evidence for half-of-the-sites reactivity and rate-limiting product release. (2003) (16)
- Interrogating dense ligand chemical space with a forward-synthetic library (2019) (15)
- A Nucleophile Activation Dyad in Ribonucleases (2002) (15)
- Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. (1994) (15)
- 1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors. (2007) (15)
- The contribution of metal ions to the conformational stability of ribonuclease T1: crystal versus solution. (2001) (15)
- Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges (2017) (15)
- Structure, substrate recognition and initiation of hyaluronan synthase (2022) (14)
- Mapping the Binding Interface between an HIV-1 Inhibiting Intrabody and the Viral Protein Rev (2013) (14)
- Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain (2014) (14)
- Polymeric nanoreactors for enzyme replacement therapy of MNGIE. (2010) (14)
- Multiple transients in the pre-steady-state of nucleoside hydrolase reveal complex substrate binding, product base release, and two apparent rates of chemistry. (2006) (14)
- Hydrophobic core manipulations in ribonuclease T1. (2001) (14)
- Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. (2017) (13)
- Structure of an early native‐like intermediate of β2‐microglobulin amyloidogenesis (2013) (13)
- Crystal structure of human Mediator subunit MED23 (2018) (13)
- Structure, mechanism, and inhibition of Hedgehog acyltransferase (2021) (13)
- Structural basis of sodium-dependent bile salt uptake into the liver (2022) (13)
- Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins (2021) (13)
- Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition (2021) (13)
- Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation (2021) (13)
- The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. (2013) (12)
- Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies* (2016) (12)
- A catalytic function for the structurally conserved residue Phe 100 of ribonuclease T1 (1996) (12)
- An engineered ribonuclease preferring phosphorothioate RNA (1998) (11)
- Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation (2021) (11)
- Reconsidering the energetics of ribonuclease catalysed RNA hydrolysis. (1998) (11)
- Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands. (2017) (11)
- Vrije Universiteit Brussel Nanobodies Raised against Monomeric alpha-Synuclein Distinguish between Fibrils at Different Maturation Stages (2017) (10)
- Snapshots of actin and tubulin folding inside the TRiC chaperonin (2021) (10)
- Anomaly in α-scattering from 6Li between 35 and 45 MeV (1975) (10)
- Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site (2020) (10)
- Dissecting histidine interactions of ribonuclease T1 with asparagine and glutamine replacements: analysis of double mutant cycles at one position. (1998) (10)
- Additivity of Protein-Guanine Interactions in Ribonuclease T1* (1997) (10)
- Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer (2011) (10)
- Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein. (2010) (10)
- Crystallographic study of Glu58Ala RNase T1 x 2'-guanosine monophosphate at 1.9-A resolution. (1994) (9)
- Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function (2018) (9)
- Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry. (2018) (9)
- Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools. (2018) (9)
- Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 (2020) (9)
- Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2. (2017) (8)
- Investigation of the functional interplay between the primary site and the subsite of RNase T1: Kinetic analysis of single and multiple mutants for modified substrates (1994) (8)
- Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2 (2021) (8)
- In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters (2020) (8)
- Examination of the mechanism and energetic contribution of leaving group activation in the purine-specific nucleoside hydrolase from Trypanosoma vivax. (2007) (8)
- A topological switch in CFTR modulates channel activity and sensitivity to unfolding (2021) (8)
- Author Correction: Structural insights into μ-opioid receptor activation (2020) (7)
- Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies (2020) (7)
- Dissection of the ribonuclease T1 subsite. The transesterification kinetics of Asn36Ala and Asn98Ala ribonuclease T1 for minimal dinucleoside phosphates. (1992) (6)
- Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex (2019) (6)
- Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family (2016) (5)
- Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology (2019) (5)
- Regulation of b 2 -Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies s (2014) (5)
- Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease. (2017) (5)
- Crystal structure determination and refinement at 2.3-A resolution of the lentil lectin. (1993) (5)
- Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM (2021) (5)
- Vrije Universiteit Brussel Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei (2010) (5)
- The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism (2020) (5)
- A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations (2020) (5)
- Structure of Nanobody Nb23 (2021) (5)
- Thermodynamics of Nanobody Binding to Lactose Permease. (2016) (5)
- Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors (2017) (5)
- Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies (2022) (5)
- A two-binding-site kinetic model for the ribonuclease-T1-catalysed transesterification of dinucleoside phosphate substrates. (1995) (5)
- Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis (2017) (4)
- Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody (2013) (4)
- Prion biology (2011) (4)
- Crystal structure of active mu-opioid receptor bound to the agonist BU72 (2015) (4)
- Expression, purification, crystallization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei. (1998) (4)
- Functional assessment of “in vivo” and “in silico” mutations in the guanine binding site of RNase T1: A DFT study (2004) (4)
- Domain-interface dynamics of CFTR revealed by stabilizing nanobodies (2019) (4)
- Discussions on the quality of antibodies are no reason to ban animal immunization (2020) (3)
- Structure and Mechanism of Hedgehog Acyl Transferase (2021) (3)
- Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues (2016) (3)
- Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors. (2018) (3)
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases. (2021) (3)
- HDX-MS optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases (2021) (3)
- Author Correction: Structural insights into the activation of metabotropic glutamate receptors (2019) (3)
- Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway. (2022) (3)
- Constructing and purifying megabodies starting from individual nanobody sequences (2021) (2)
- Structures of influenza A virus RNA polymerase offer insight into viral genome replication (2019) (2)
- CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38. (2019) (2)
- Malaria invasion machinery protein-Nanobody complex (2013) (2)
- Regulation of a Class III PI3K Lipid Kinase (VPS34 Complex II) by the Small G Protein Rab5A: Single Molecule Analysis Reveals a Dual Regulatory Mechanism. (2020) (2)
- Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. (2019) (2)
- Diversity in kinetics correlated with structure in nano body-stabilized LacY (2020) (2)
- Quantum chemical study of leaving group activation in T. vivax nucleoside hydrolase (2006) (2)
- Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment. (2014) (2)
- Quiescin-sulfhydryl oxidase inhibits prion formation in vitro (2016) (2)
- Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS (2022) (2)
- Crystal structure determination and refinement at 2.3-.ANG. resolution of the lentil lectin. [Erratum to document cited in CA119(17):176148u] (1993) (2)
- Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C (2022) (2)
- CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38. (2019) (2)
- Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1. (2018) (1)
- Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor (2018) (1)
- Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor (2018) (1)
- Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein. (2013) (1)
- Nanobody-stabilize the crystal structure of full-length human PrP (2012) (1)
- Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (2018) (1)
- Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 (2016) (1)
- Crystal structure of Staphylococcus capitis divalent metal ion transporter (DMT) in complex with nanobody (2014) (1)
- Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 (2013) (1)
- s1.m7.p17 Structure of YbeK pyrimidine hydrolase from E. coli: understanding a possible new helper in cancer (2004) (0)
- An Intrabody based on a Llama Single-domain Antibody Targeting the N-terminal α-Helical Multimerization Domain of HIV-1 Rev Inhibits Viral Replication (2010) (0)
- X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) F16'S pore mutant (F247S) with alternate M4 conformation. (2019) (0)
- Competitive, connective and allosteric Nanobodies that modulate the SOS1•RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design (2023) (0)
- Development of a Novel Triblock Copolymer Therapeutic Nanoreactor (2006) (0)
- Brussel Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma (0)
- Characterisation and structure determination of a llama-derived nanobody targeting the J-base binding protein 1 (2018) (0)
- Structure, substrate recognition and initiation of hyaluronan synthase (2022) (0)
- X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 (2019) (0)
- Dissecting lipid contents in the distinct regions of native retinal rod disk membranes (2021) (0)
- X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP (2007) (0)
- Vrije Universiteit Brussel Development by Genetic Immunization of Monovalent Antibodies ( Nanobodies ) Behaving as Antagonists of the Human ChemR 23 Receptor (2017) (0)
- Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex (2019) (0)
- Crystal structure of the Patched ectodomain in complex with nanobody NB64 (2019) (0)
- X-ray structure of phenylpyruvate decarboxylase in complex with 2-(1-hydroxyethyl)-3-deaza-ThDP (2007) (0)
- A Functionally Conserved Mechanism of Modulation via a Vestibule Site in Pentameric Ligand-Gated Ion Channels (2019) (0)
- Crystal structure of Megabody Mb-Nb207-c7HopQ_G10 (2021) (0)
- ALLOSTERIC MODULATION OF THE PENTAMERIC LIGAND‐GATED ION CHANNEL ELIC BY FUNCTIONALLY ACTIVE NANOBODIES (2018) (0)
- Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma vivax: Trp260Ala Mutant In Complex With 3-Deaza-Adenosine (2002) (0)
- PglK flippase in complex with inhibitory nanobody (2017) (0)
- Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol (2009) (0)
- Fitting results in the I-layer of the subnanometer structure of the bacterial pKM101 type IV secretion system core complex digested with elastase (2013) (0)
- Nanobody-aided crystallization of the transcription regulator PaaR2 from Escherichia coli O157:H7. (2021) (0)
- A Small Llama Antibody Fragment Efficiently Inhibits the HIV Rev Multimerization In Vitro (2009) (0)
- RIBONUCLEASE T1 (ASN9ALA/THR93ALA DOUBLEMUTANT) COMPLEXED WITH 2'GMP (1998) (0)
- Author Correction: Structural insights into the activation of metabotropic glutamate receptors (2019) (0)
- RIBONUCLEASE T1 COMPLEX WITH 2'GMP (1998) (0)
- Brussel Histidine-40 of ribonuclease T 1 acts as base catalyst when the true catalytic base , glutamic acid-58 , is replaced by alanine (2001) (0)
- human NBD1 of CFTR in complex with nanobodies T2a and T4 (2019) (0)
- The structural mechanism of transport by the mitochondrial ADP/ATP carrier (2018) (0)
- Staphylococcus capitis divalent metal ion transporter (DMT) in complex with manganese (2014) (0)
- CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 (2021) (0)
- Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate (2019) (0)
- Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein (2010) (0)
- DISECTING HISTIDINE INTERACTIONS IN RIBONUCLEASE T1 USING ASN AND GLN MUTATIONS (1997) (0)
- Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol (2009) (0)
- Editorial overview: Engineered proteins as tools in structural biology. (2020) (0)
- Crystal structure of the Patched-1 (PTCH1) ectodomain 1 (2019) (0)
- CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. (2019) (0)
- Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71 (2018) (0)
- Disruption of protein dynamics by an allosteric effector antibody (2010) (0)
- RIBONUCLEASE T1 V16A MUTANT IN COMPLEX WITH MG2 (2001) (0)
- Protein Structure and Biology (2013) (0)
- RIBONUCLEASE T1 COMPLEXED WITH 2'GMP/G23A MUTANT (1998) (0)
- Crystal structure of human Mediator subunit MED23 (2018) (0)
- Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM (2021) (0)
- Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology (2019) (0)
- Crystal structure of Sulfolobus acidocaldarius TrmJ (2014) (0)
- Challenges at low resolution: crystal structure of the yeast VPS34 complex II. (2016) (0)
- Crystal structure of loop deletion mutant of Trypanosoma vivax nucleoside hydrolase (3GTvNH) in complex with ImmH (2008) (0)
- X-RAY STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN (2016) (0)
- Crystal structure of Megabody Mb-Nb207-c7HopQ_A12 (2021) (0)
- Human NBD1 of CFTR in complex with nanobodies D12 and T4 (2019) (0)
- Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance (2022) (0)
- Structural basis of sodium-dependent bile salt uptake into the liver (2022) (0)
- Targeting the HIV-1 Rev Multimerization by single-domain Nanobodies (2009) (0)
- Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody (2020) (0)
- Erratum: Author Correction: Structural insights into the activation of metabotropic glutamate receptors (Nature (2019) 566 7742 (79-84)) (2019) (0)
- Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition (2023) (0)
- Characterisation of B1 metallo-beta-lactamase inhibition by VHHs (2010) (0)
- CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38. (2019) (0)
- CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX (2001) (0)
- A Topological Switch Enables Misfolding of the Cystic Fibrosis Transmembrane Conductance Regulator (2020) (0)
- Author response: Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site (2020) (0)
- X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP and 5-phenyl-2-oxo-valeric acid (2007) (0)
- Structure of the bongkrekic acid-inhibited mitochondrial ADP/ATP carrier (2019) (0)
- Inosine-Guanosine Nucleoside Hydrolase (IG-NH) (2010) (0)
- RIBONUCLEASE T1, PHE 100 TO ALA MUTANT COMPLEXED WITH 2' GMP (1996) (0)
- Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc (2019) (0)
- Ribonuclease T1 V89S mutant (2001) (0)
- Structure of the Beta2_microglobulin involved in amyloidogenesis (2011) (0)
- Characterization of the inhibition of metallo-β-lactamases of subclass B1 by VHHs cAbVIM4 and cAbBCII10 (2011) (0)
- A Topological Switch in the Cystic Fibrosis Transmembrane Conductance Regulator Modulates Channel Activity and Sensitivity to Disease-Causing Mutation (2020) (0)
- Nanobody ca1697 binding to the DHFR.folate binary complex (2013) (0)
- Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer (2019) (0)
- DISECTING HISTIDINE INTERACTIONS IN RIBONUCLEASE T1 BY ASN AND GLN SUBSTITUTIONS (1997) (0)
- Thermodynamic Insights into Conformational Dynamics of Sugar Transporters (2016) (0)
- Crystal structure of Trypanosoma vivax nucleoside hydrolase soaked with ImmucillinH (2006) (0)
- Crystal structure of the artificial nanobody octarellinV.1 complex (2016) (0)
- In Vivo and in Vitro Characterizations of Conformational Nanobodies of Salmonella Enterica Serovar Typhimurium Melibiose Permease Melb (2023) (0)
- Ribonuclease T1 V16A mutant, form II (2001) (0)
- Evaluation of nucleoside hydrolase inhibitors for the treatment of 1 African trypanosomiasis (2010) (0)
- Distinct binding and activation modes of the atypical chemokine receptor ACKR3/CXCR7 by chemokine and endogenous non-chemokine agonists (2018) (0)
- ADDITIVITY OF SUBSTRATE BINDING IN RIBONUCLEASE T1 (Y42A MUTANT) (1997) (0)
- Vrije Universiteit Brussel Polymeric nanoreactors for enzyme replacement therapy by MNGIE (2010) (0)
- Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies (2022) (0)
- Atypical Ligand Binding and Activation Modes of ACKR3/CXCR7 (2018) (0)
- Crystal structure of Trypanosoma vivax nucleoside hydrolase co-crystallized with ImmucillinH (2006) (0)
- Crystal structure of Megabody Mb-Nb207-cYgjK_NO (2021) (0)
- Generation of single-domain antidoby fragments raised against proteins containing polyglutamine expansions (2010) (0)
- Crystal structure of E.coli TrmJ (2014) (0)
- Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody. (2014) (0)
- Crystal structure of E.coli TrmJ in complex with S-adenosyl-L- homocysteine (2014) (0)
- Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6∊-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum (2013) (0)
- New catalytic strategies for leaving group activation in nucleoside hydrolases (2006) (0)
- Structure of PINK1 bound to ubiquitin (2017) (0)
- X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP and phenylpyruvate (2007) (0)
- Structural Basis for Allosteric Coupling Between G Protein and the Agonist‐Binding Pocket in GPCRs (2016) (0)
- Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS. (2023) (0)
- RIBONUCLEASE T1: FREE HIS92GLN MUTANT (1998) (0)
- human NBD1 of CFTR in complex with nanobody T27 (2019) (0)
- Human NBD1 of CFTR in complex with nanobodies D12 and T8 (2019) (0)
- Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax (2019) (0)
- Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody (2020) (0)
- Atomic model for the N-terminus of TraO fitted in the full-length structure of the bacterial pKM101 type IV secretion system core complex (2013) (0)
- Downsizing Nanobodies: Towards CDR Loop Mimetics Modulating Intracellular Protein-Protein Interactions (2022) (0)
- Crystal structure of phenylpyruvate decarboxylase of Azospirillum brasilense (2007) (0)
- Stabilization of Meta‐I Rhodopsin Conformation by a Nanobody (2022) (0)
- Crystal Structure of a ligand bound LacY/Nanobody Complex (2018) (0)
- Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation (2021) (0)
- Crystal structure of a the E. coli pyrimidine nucleoside hydrolase YbeK with bound ribose (2006) (0)
- An improved yeast surface display platform for the screening of nanobody immune libraries (2019) (0)
- Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 (2017) (0)
- Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 (2019) (0)
- RIBONUCLEASE T1 (N9A MUTANT) COMPLEXED WITH 2'GMP (1998) (0)
- X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 (2019) (0)
- Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 (2020) (0)
- Nanobody-enabled monitoring of kappa opioid receptor states (2020) (0)
- Polypeptides novel chimeric for purposes of examination and drug discovery (2014) (0)
- X-ray structure of the H40A/E58A mutant of Ribonuclease T1 complexed with 3'-guanosine monophosphate (2002) (0)
- Ric8A-Gα, a Complex Structure of a Guanine Nucleotide Exchange Factor (2020) (0)
- R104A-ca1697 nanobody binding to the binary DHFR.folate complex (2013) (0)
- RIBONUCLEASE T1 IN COMPLEX WITH 2'GMP (FORM II CRYSTAL) (2001) (0)
- NANOBODIES FOR THE STRUCTURAL AND FUNCTIONAL INVESTIGATION OF GPCR TRANSMEMBRANE SIGNALING (2014) (0)
- Allosteric inhibition of VIMs metallo-β-lactamases by a camelid single-domain antibody fragment. (2012) (0)
- RIBONUCLEASE T1 (WILDTYPE) COMPLEXED WITH 2'GMP (1998) (0)
- A Lipid Recognition Site at a Transmembrane Helix Kink Shapes the Agonist Response of a Pentameric Ligand-gated Ion Channel (2020) (0)
- Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 (2019) (0)
- Novel chimeric polypeptides for screening and lægemiddeldetektionsformål (2014) (0)
- Author response: In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters (2020) (0)
- CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38. (2019) (0)
- Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone (2017) (0)
- Ribonuclease T1 V78T mutant (2001) (0)
- L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction (2019) (0)
- CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE (2001) (0)
- cAbVIM4, a nanobody inhibiting the metallo-β-lactamase VIM-4 (2010) (0)
- Mechanisms of GABAA receptor signalling revealed by structural pharmacology (2019) (0)
- Author response: A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations (2020) (0)
- Brussel Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum (2019) (0)
- Structural Basis for Allosteric Enhancement of Agonist Affinity by G Proteins (2015) (0)
- Structural basis of membrane targeting and coatomer assembly by human GBP1 (2023) (0)
- Crystal and cryo-EM structures of the cytosolic G protein alpha chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 (2020) (0)
- Ribonuclease T1 V16C mutant (2000) (0)
- In Vivo and In Vitro Characterizations of Nanobodies Raised Against the Melibiose Permease melB of Salmonella Typhimurium (2021) (0)
- Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo (2013) (0)
- human NBD1 of CFTR in complex with nanobodies D12 and G3a (2019) (0)
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