Jana Sawynok
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Researcher ORCID ID = 0000-0003-3792-834X
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(Suggest an Edit or Addition)Jana Sawynok's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- On the specificity of naloxone as an opiate antagonist. (1979) (611)
- Adenosine receptor activation and nociception. (1998) (469)
- Adenosine in the spinal cord and periphery: release and regulation of pain (2003) (341)
- Topical and Peripherally Acting Analgesics (2003) (335)
- Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. (1993) (255)
- Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline. (1976) (212)
- The role of purines in nociception (1989) (201)
- Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. (2001) (200)
- GABAergic mechanisms of analgesia: An update (1987) (180)
- Classification of adenosine receptors mediating antinociception in the rat spinal cord (1986) (157)
- Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects (1999) (155)
- Adenosine receptor targets for pain (2016) (152)
- Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes (1997) (139)
- Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine (1999) (136)
- Topical 2% Amitriptyline and 1% Ketamine in Neuropathic Pain Syndromes: A Randomized, Double-blind, Placebo-controlled Trial (2005) (135)
- Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat (1998) (134)
- Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord. (1989) (120)
- On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine (1982) (117)
- Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. (2005) (117)
- Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat (1999) (116)
- A Pilot Study Examining Topical Amitriptyline, Ketamine, and a Combination of Both in the Treatment of Neuropathic Pain (2003) (107)
- Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. (1987) (106)
- The therapeutic use of heroin: a review of the pharmacological literature. (1986) (101)
- Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor. (1997) (94)
- Caffeine and pain (2011) (93)
- Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization (1984) (91)
- Adenosine release may mediate spinal analgesia by morphine. (1989) (90)
- Enkephalin effects on release of brain acetylcholine (1977) (88)
- Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. (1995) (86)
- Adenosine and ATP receptors. (2007) (84)
- Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. (2000) (84)
- Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. (1997) (84)
- ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin (1993) (80)
- Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen. (1988) (79)
- Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design (2003) (78)
- A randomized controlled trial of qigong for fibromyalgia (2012) (77)
- Novel aspects of pain management : opioids and beyond (1999) (76)
- Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat. (1995) (76)
- Pharmacological Rationale for the Clinical Use of Caffeine (2012) (73)
- The Formalin Test: Characteristics and Usefulness of the Model (2003) (73)
- Topical analgesics for neuropathic pain: Preclinical exploration, clinical validation, future development (2014) (71)
- Interactions of descending serotonergic systems with other neurotransmitters in the modulation of nociception (1995) (69)
- Adenosine kinase inhibitors augment release of adenosine from spinal cord slices. (1996) (68)
- Peripheral Antihyperalgesic and Analgesic Actions of Ketamine and Amitriptyline in a Model of Mild Thermal Injury in the Rat (2003) (67)
- Topical analgesics in neuropathic pain. (2005) (67)
- The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. (1989) (67)
- Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. (2001) (66)
- Gabaergic mechanisms in antinociception (1984) (66)
- Antinociception by tricyclic antidepressants in the rat formalin test: differential effects on different behaviours following systemic and spinal administration (2001) (60)
- Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test (1998) (60)
- Morphine releases endogenous adenosine from the spinal cord in vivo. (1987) (60)
- Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes. (1995) (60)
- Prolonged hyperprolactinemia influences beta-endorphin and Met-enkephalin in the brain. (1980) (59)
- Methylxanthines and pain. (2011) (59)
- Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. (2002) (58)
- D-Baclofen is an antagonist at baclofen receptors mediating antinociception in the spinal cord. (1985) (58)
- Pain catastrophizing predicts poor response to topical analgesics in patients with neuropathic pain. (2012) (57)
- Topical and Peripheral Ketamine as an Analgesic (2014) (56)
- Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. (1999) (56)
- Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms (1995) (54)
- GABA and baclofen potentiate the K+-evoked release of methionine-enkephalin from rat striatal slices. (1981) (46)
- Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium. (1978) (41)
- Morphine Activates ω‐Conotoxin‐Sensitive Ca2+ Channels to Release Adenosine from Spinal Cord Synaptosomes (1993) (41)
- Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine. (1994) (41)
- Intrathecal but not intravenous opioids release adenosine from the spinal cord. (2004) (41)
- Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the quinea pig ileum and its status after chronic exposure to morphine. (1977) (40)
- The Interaction Between Gabapentin and Amitriptyline in the Rat Formalin Test After Systemic Administration (2002) (39)
- Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors (2013) (39)
- Substance P, injected intrathecally, antagonizes the spinal antinociceptive effect of morphine, baclofen and noradrenaline (1984) (37)
- Role of ascending and descending noradrenergic pathways in the antinociceptive effect of baclofen and clonidine (1986) (37)
- Adenosine A1 Receptor-Dependent Antinociception Induced by Inosine in Mice: Pharmacological, Genetic and Biochemical Aspects (2014) (35)
- Caffeine inhibits antinociception by acetaminophen in the formalin test by inhibiting spinal adenosine A₁ receptors. (2012) (35)
- Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine. (1991) (35)
- 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord (1988) (34)
- 5-Hydroxytryptamine releases adenosine and cyclic AMP from primary afferent nerve terminals in the spinal cord in vivo (1990) (34)
- Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism. (1991) (33)
- Spinal and peripheral adenosine A₁ receptors contribute to antinociception by tramadol in the formalin test in mice. (2013) (33)
- Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats. (1996) (33)
- Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats (2003) (33)
- Effect of 6-hydroxydopamine-induced lesions to ascending and descending noradrenergic pathways on morphine analgesia (1987) (33)
- Qigong and Fibromyalgia: Randomized Controlled Trials and Beyond (2014) (33)
- Peripheral P2X receptors and nociception: interactions with biogenic amine systems (2004) (32)
- Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. (1992) (31)
- Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake. (2005) (30)
- Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine (1992) (30)
- Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury (2009) (29)
- Nontricyclic antidepressant analgesics and pain: Are serotonin norepinephrine reuptake inhibitors (SNRIs) any better? (2011) (29)
- Glutamate-evoked release of adenosine and regulation of peripheral nociception (2004) (29)
- Modulation of adenosine release from rat spinal cord by adenosine deaminase and adenosine kinase inhibitors (1995) (28)
- Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors (2008) (28)
- Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline. (2013) (28)
- Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury. (2006) (27)
- A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain. (2010) (27)
- Potentiation of formalin-evoked adenosine release by an adenosine kinase inhibitor and an adenosine deaminase inhibitor in the rat hind paw: a microdialysis study. (2000) (26)
- Effects of morphine and naloxone on the K+-stimulated release of methionine-enkephalin from slices of rat corpus striatum (1980) (26)
- D-baclofen: Is it an antagonist at baclofen receptors? (1984) (25)
- Baclofen activates two distinct receptors in the rat spinal cord and guinea pig ileum (1986) (25)
- Involvement of Calcium Channels in Depolarization‐Evoked Release of Adenosine from Spinal Cord Synaptosomes (1993) (24)
- Catastrophizing and treatment outcome: differential impact on response to placebo and active treatment outcome (2008) (24)
- Evidence for the involvement of descending noradrenergic pathways in the antinociceptive effect of baclofen (1985) (24)
- Alpha1-adrenergic receptors augment P2X3 receptor-mediated nociceptive responses in the uninjured state. (2007) (23)
- Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation. (1986) (23)
- Caffeine antinociception: role of formalin concentration and adenosine A1 and A2 receptors. (1996) (23)
- Synergy between μδ-opioid receptors mediates adenosine release from spinal cord synaptosomes (1996) (22)
- Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines. (1988) (22)
- The effect of benzodiazepines on the analgesic effect of morphine and sodium salicylate. (1973) (22)
- Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine (1993) (22)
- Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw oedema induced by adenosine A(1) and A(2B/3) receptor agonists. (2000) (22)
- Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine (1991) (22)
- Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin‐sensitive sensory afferents (2002) (21)
- Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain (2016) (21)
- Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: Insights using knockout mice (2010) (21)
- Interactions of methylxanthines, nonxanthine phosphodiesterase inhibitors, and calcium with morphine in the guinea pig myenteric plexus. (1979) (20)
- Peripheral Amitriptyline Suppresses Formalin-Induced Fos Expression in the Rat Spinal Cord (2002) (20)
- Contributions of peripheral, spinal, and supraspinal actions to analgesia. (2014) (20)
- Involvement of primary sensory afferents, postganglionic sympathetic nerves and mast cells in the formalin-evoked peripheral release of adenosine. (2001) (19)
- Adenosine and Pain (2013) (19)
- Plasma concentration and urinary excretion of guanidine derivatives in normal subjects and patients with renal failure (1975) (19)
- Enhancement of clonidine-induced analgesia by lesions induced with spinal and intracerebroventricular administration of 5,7-dihydroxytryptamine (1987) (19)
- Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. (1999) (18)
- Topical Analgesics for Neuropathic Pain in the Elderly: Current and Future Prospects (2014) (18)
- Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine. (1991) (18)
- Lesions to ascending noradrenergic and serotonergic pathways modify antinociception produced by intracerebroventricular administration of morphine (1989) (16)
- 8-Phenyltheophylline reverses the antinociceptive action of morphine in the periaqueductal gray (1991) (16)
- Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone. (1987) (16)
- Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord (1990) (16)
- Qigong and Fibromyalgia circa 2017 (2017) (14)
- Adenosine triphosphate and adenosine receptors and pain (2015) (13)
- Chaoyi Fanhuan Qigong and fibromyalgia: methodological issues and two case reports. (2013) (13)
- Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes. (1996) (12)
- Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents (2002) (12)
- Extension Trial of Qigong for Fibromyalgia: A Quantitative and Qualitative Study (2013) (12)
- Substance P releases and augments the morphine-evoked release of adenosine from spinal cord (1997) (12)
- Modality Specific Analgesia Produced by Intrathecal Anti-Substance P Antibody (1987) (11)
- Involvement of GABA in the antinociceptive effect of gamma-acetylenic GABA (GAG), an inhibitor of GABA-transaminase. (1983) (11)
- Adrenergic regulation of P2X3 and TRPV1 receptors: Differential effects of spared nerve injury (2008) (10)
- Theophylline‐induced potentiation of the antinociceptive action of baclofen (1983) (10)
- Naloxone antagonizes inhibitory and unmasks excitatory effects of baclofen (1981) (10)
- Qualitative analysis of a controlled trial of qigong for fibromyalgia: advancing understanding of an emerging health practice. (2014) (9)
- A pilot trial of CFQ for treatment of fibromyalgia. (2009) (9)
- Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes. (1991) (6)
- Pertussis toxin inhibits morphine-induced release of adenosine from the spinal cord. (1990) (6)
- Antidepressants as analgesics: an introduction. (2001) (6)
- Adenosine and pain: Recent findings with directly and indirectly acting agents (1998) (5)
- Opioid and Nonopioid Antinociception as Revealed by Lesion Studies (1991) (5)
- Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro (1982) (5)
- Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model (2011) (4)
- Clonidine reverses baclofen-induced increases in noradrenaline turnover in rat brain (1986) (4)
- Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception (1985) (4)
- Modulation of Nociception by Descending Serotoninergic Projections (2000) (4)
- Role of ascending and descending serotonergic pathways in the antinociceptive effect of baclofen (1988) (4)
- 1-Adrenergic Receptors Augment P 2 X 3 Receptor – Mediated ociceptive Responses in the Uninjured State (2007) (4)
- Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites (1990) (4)
- Qigong, Parasympathetic Function and Fibromyalgia (2016) (4)
- Influence of calcium on the release of endogenous adenosine from spinal cord synaptosomes. (1993) (4)
- Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors. (2004) (3)
- Qigong and Chronic Pain: Three Cases of Pain Resolution, Other Health Benefits and Improved Vision with Long-term Practice of Qigong (2016) (3)
- Amitriptyline neurotoxicity. (2005) (3)
- RECENT FINDINGS SURROUNDING TOPICAL ANTIDEPRESSANTS AS ANALGESICS AND REVIEW OF EXISTING AND EMERGING TOPICAL ANALGESICS * — (2003) (3)
- Chronic intrathecal cannulas inhibit some and potentiate other behaviors elicited by formalin injection (2003) (3)
- Benefits of Tai Chi for fibromyalgia. (2018) (2)
- Case Series of Multiple Health Benefits in Those Undertaking Extended Qigong Practice as a Complementary Self-care Practice in an Outpatient Pain Clinic (2019) (2)
- Monoamines as mediators of the antinociceptive effect of baclofen (1983) (2)
- 36th Annual Scientific Meeting of the Canadian Pain Society: Abstracts (2015) (2)
- Observational Study of Qigong as a Complementary Self-Care Practice at a Tertiary-Care Pain Management Unit (2021) (1)
- Chapter 6. Adenosine Receptors (2009) (1)
- Adenosine — A peripheral neuronal modulator of pain and inflammation (2003) (1)
- Classification ofadenosine receptors mediating antinociception intheratspinal cord (1986) (1)
- Adenosine release by morphine and spinal antinociception: role of G-proteins and cyclic AMP. (1990) (1)
- Intracerebrovetricular morphine releases cyclic AMP and adenosine from the spinal cord via a serotonergic mechanism (1990) (1)
- Intrathecal Substance P Produces a Long-Term Inhibition of the Spinal Analgesic Effect of Noradrenaline (1987) (1)
- Evaluation OF 5-HT1 Receptor Sub'iypes Interacting with Spinal Noradrenergic Systems in Two Tests for Nociception (1993) (0)
- 17. Topical Analgesics (2010) (0)
- Pharmacology On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine Neuropharmacology, 21 (1982) 397–403 (1982) (0)
- Adenosine release from the spinal cord may mediate antinodideption by intracerebroventricular morphine (1989) (0)
- INTERACTIONS BETWEEN OPIOID AND ADENOSINE SYSTEMS (1995) (0)
- Spinal cord expression of the heat shock protein (HSP27) in a rat model of neuropathic pain following tight ligation of L5 and L6 dorsal roots. (1998) (0)
- Primary afferents: Antidepressants enhance extracellular levels of adenosine in the rat hindpaw and inhibit adenosine uptake (2004) (0)
- Letter to the editor (2000) (0)
- Adenosine A1 Receptor-Dependent Antinociception Induced by Inosine in Mice: Pharmacological, Genetic and Biochemical Aspects (2014) (0)
- Primary afferents: ATP-noradrenaline interactions and peripheral pain signaling (2004) (0)
- Morphine releases adenosine from capsaicin-sensitive neurons in the spinal cord (1988) (0)
- Serotonin releases adenosine from primary afferent nerve terminals in the spinal cord (1988) (0)
- Function of heat shock protein (Hsp27) in neuropathic pain: identification of new brain-specific Hsp27-interacting proteins (1998) (0)
- Reply to G. McCleane: PAIN 4098 (2000) (0)
- Tricyclic Antidepressants As Analgesics in the Elderly (2006) (0)
- Title Morphine Activates ?-Conotoxin-Sensitive Ca 2 + Channels to Release Adenosine from Spinal Cord (2006) (0)
- 2347 – ANTAGONISM OF MORPHINE ACTION ON ACETYLCHOLINE RELEASE BY METHYLXANTHINES AND CALCIUM (1978) (0)
- Pharmacological management of neuropathic pain in patients with vestibular schwannomas: Experience of the Atlantic Lateral Skull Base Clinic (2014) (0)
- Hyperalgesia produced byintrathecal substance Pand related peptides: desensitization andcross desensitization (1984) (0)
- Antidepressants as analgesics : an introduction : Psychopharmacology of Pain Symposium (2001) (0)
- History of the Pharmacological Society of Canada 1956-2008. (2020) (0)
- Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine Sweeney, M.I., White, T.D. and Sawynok, J., Brain Research, 614 (1993) 301–307 (1993) (0)
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