Jane Sowden

Jane Sowden's AcademicInfluence.com Rankings

Jane Sowden

Biology

#4099

World Rank

#6157

Historical Rank

Developmental Biology

#186

World Rank

#194

Historical Rank

Genetics

#839

World Rank

#932

Historical Rank

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Biology

Why Is Jane Sowden Influential?

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According to Wikipedia, Jane Caroline Sowden is a British biologist who is Professor of Developmental Biology and Genetics at the Great Ormond Street Hospital for Children NHS Foundation Trust. Her research investigates eye formation and repair by developing a better understanding the genetic pathways that regulate eye development.

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Jane Sowden's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Retinal repair by transplantation of photoreceptor precursors (2006) (853)
Restoration of vision after transplantation of photoreceptors (2012) (448)
Fox's in development and disease. (2003) (367)
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina (2013) (359)
A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene (2000) (315)
Human microphthalmia associated with mutations in the retinal homeobox gene CHX10 (2000) (293)
Repair of the degenerate retina by photoreceptor transplantation (2012) (252)
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors (2016) (234)
A review of anterior segment dysgeneses. (2006) (167)
Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors (2008) (161)
Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors (2017) (154)
Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells. (1999) (146)
Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH (2006) (143)
A single‐cell transcriptome atlas of the adult human retina (2019) (139)
Molecular and developmental mechanisms of anterior segment dysgenesis (2007) (138)
Defining the Integration Capacity of Embryonic Stem Cell‐Derived Photoreceptor Precursors (2012) (134)
Long‐Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation (2010) (123)
Targeted Disruption of Outer Limiting Membrane Junctional Proteins (Crb1 and ZO-1) Increases Integration of Transplanted Photoreceptor Precursors into the Adult Wild-Type and Degenerating Retina (2010) (119)
Effective Transplantation of Photoreceptor Precursor Cells Selected via Cell Surface Antigen Expression (2011) (119)
Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells (2010) (109)
Adult Ciliary Epithelial Cells, Previously Identified as Retinal Stem Cells with Potential for Retinal Repair, Fail to Differentiate into New Rod Photoreceptors (2010) (109)
Anophthalmos, microphthalmos, and typical coloboma in the United Kingdom: a prospective study of incidence and risk. (2011) (108)
The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup (2006) (101)
Cell transplantation strategies for retinal repair. (2009) (100)
Ocular developmental abnormalities and glaucoma associated with interstitial 6p25 duplications and deletions. (2002) (97)
Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. (2001) (96)
Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell‐Derived Self‐Forming Retina (2015) (94)
Comparative Analysis of Progenitor Cells Isolated from the Iris, Pars Plana, and Ciliary Body of the Adult Porcine Eye (2007) (88)
Brief Report: Self‐Organizing Neuroepithelium from Human Pluripotent Stem Cells Facilitates Derivation of Photoreceptors (2013) (81)
Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner (2018) (78)
Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells (2017) (76)
The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. (1996) (76)
Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. (2014) (74)
Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration (2017) (74)
ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies. (2013) (64)
ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. (2012) (64)
The Oculome Panel Test: Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders. (2019) (63)
Anophthalmos, microphthalmos, and Coloboma in the United kingdom: clinical features, results of investigations, and early management. (2012) (61)
Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell‐Derived Retinal Organoids and Fetal Retinae (2018) (59)
X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development. (2012) (58)
The Caudal ‐Type Homeobox Protein Cdx‐2 Binds to the Colon Promoter of the Carbonic Anhydrase 1 Gene (1996) (55)
Genes and pathways in optic fissure closure. (2017) (52)
Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene. (2000) (49)
Genetic mapping of the human homologue (T) of mouse T(Brachyury) and a search for allele association between human T and spina bifida. (1996) (49)
Colon carbonic anhydrase 1: transactivation of gene expression by the homeodomain protein Cdx2 (1998) (48)
A novel mechanistic spectrum underlies glaucoma-associated chromosome 6p25 copy number variation. (2008) (48)
Foxn4 – a new member of the forkhead gene family is expressed in the retina (2001) (47)
A novel homeobox mutation in the PITX2 gene in a family with Axenfeld‐Rieger syndrome associated with brain, ocular, and dental phenotypes (2006) (47)
Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. (2009) (45)
Digenic inheritance of mutations in FOXC1 and PITX2 : Correlating transcription factor function and axenfeld‐rieger disease severity (2011) (43)
Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina. (2001) (43)
Manipulation of the Recipient Retinal Environment by Ectopic Expression of Neurotrophic Growth Factors Can Improve Transplanted Photoreceptor Integration and Survival (2012) (42)
Mutation of SALL2 causes recessive ocular coloboma in humans and mice (2014) (41)
Expression from the proximal promoter of the carbonic anhydrase 1 gene as a marker for differentiation in colon epithelia. (1993) (39)
Absence of chx10 causes neural progenitors to persist in the adult retina. (2006) (38)
Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive Anterior Segment Dysgenesis (2016) (37)
Chromosome abnormalities and the genetics of congenital corneal opacification (2011) (32)
The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. (1995) (31)
Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. (2004) (28)
Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision (2019) (28)
Induced pluripotent stem cell technology for generating photoreceptors. (2011) (28)
Regenerative medicine: DIY eye (2011) (27)
A novel heterozygous SOX2 mutation causing congenital bilateral anophthalmia, hypogonadotropic hypogonadism and growth hormone deficiency. (2014) (26)
Multiple GF‐1 binding sites flank the erythroid specific transcription unit of the human carbonic anhydrase I gene (1989) (25)
The caudal-type homeobox protein Cdx-2 binds to the colon promoter of the carbonic anhydrase 1 gene. (1997) (24)
Neuronal function of Tbx20 conserved from nematodes to vertebrates. (2008) (24)
Comparative analysis of the retinal potential of embryonic stem cells and amniotic fluid-derived stem cells. (2011) (24)
Derepression of HMGA2 Gene Expression in Retinoblastoma Is Associated with Cell Proliferation (2003) (24)
FOVEAL CAVITATION AS AN OPTICAL COHERENCE TOMOGRAPHY FINDING IN CENTRAL CONE DYSFUNCTION (2012) (24)
Genetic risk for primary open-angle glaucoma determined by LMX1B haplotypes. (2009) (24)
Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion (2019) (23)
CYP1B1-related anterior segment developmental anomalies novel mutations for infantile glaucoma and von Hippel's ulcer revisited. (2011) (23)
Structure and methylation patterns of the gene encoding human carbonic anhydrase I. (1990) (22)
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development (2012) (21)
The human carbonic anhydrase I gene has two promoters with different tissue specificities. (1991) (18)
Functional Analysis of FOXE3 Mutations Causing Dominant and Recessive Ocular Anterior Segment Disease (2015) (17)
NRL−/− gene edited human embryonic stem cells generate rod‐deficient retinal organoids enriched in S‐cone‐like photoreceptors (2021) (15)
Isolation and characterisation of neural progenitor cells from the adult Chx10 orJ/orJ central neural retina (2008) (13)
Clinical utility gene card for: Non-Syndromic Microphthalmia Including Next-Generation Sequencing-Based Approaches (2017) (12)
Generation of human neural retina transcriptome atlas by single cell RNA sequencing (2018) (12)
ESC-derived retinal pigmented epithelial cell transplants in patients: so far, so good. (2014) (12)
Erythroid expression and DNAaseI-hypersensitive sites of the carbonic anhydrase 1 gene. (1992) (12)
The Structure and Regulation of the Human Carbonic Anhydrase I Gene (1991) (12)
Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement. (2016) (12)
Restoring Vision Using Stem Cells and Transplantation. (2019) (11)
Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder (2020) (10)
A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l). (1995) (10)
The need for widely available genomic testing in rare eye diseases: an ERN-EYE position statement (2021) (10)
Characterisation and Validation of Insertions and Deletions in 173 Patient Exomes (2012) (9)
An unusual 5′-leader in the human erythroid-specific carbonic anhydrase I gene (1989) (8)
A molecular and cellular analysis of human embryonic optic fissure closure related to the eye malformation coloboma (2020) (7)
Regulation of the CA1, CA2 and CA3 genes. (2000) (6)
Anterior Segment Developmental Anomalies (2005) (6)
Therapy may yet stem from cells in the retina (2003) (6)
Isolation and culture of adult ciliary epithelial cells, previously identified as retinal stem cells, and retinal progenitor cells. (2011) (5)
Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. (1998) (5)
Chapter 4 - Restoring Vision to the Blind: Stem Cells and Transplantation. (2014) (5)
Disorders of the Eye as a whole (1997) (5)
Impact of sight and hearing loss in patients with Norrie disease: advantages of Dual Sensory clinics in patient care (2020) (4)
Chapter 8 - Restoring Vision to the Blind: Evaluating Visual Function, Endpoints. (2014) (3)
Mutation of SALL 2 causes recessive ocular coloboma in humans and mice (2014) (3)
Common TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma (2012) (3)
Monitoring ferumoxide-labelled neural progenitor cells and lesion evolution by magnetic resonance imaging in a model of cell transplantation in cerebral ischaemia (2013) (2)
Stem cell therapy for blindness: new developments and implications for the future (2011) (2)
Generation of a Cone Photoreceptor-specific GNGT2 Reporter Line in Human Pluripotent Stem Cells. (2022) (2)
Successful Transplantation of Photoreceptors into the Retina of an Adult Mouse Model of Human Retinitis Pigmentosa (2006) (2)
Pattern Onset ERGs and VEPs Produced by Patterns Arising From Light Increment and Decrement. (2018) (2)
Modulation Of Gliosis Using shGFAP Or/and shvimentin To Determine Its Role In Photoreceptor Transplantation Efficiency (2012) (2)
The identification of novel sequences expressed in the mouse notochord (2009) (2)
Do-It-Yourselfで眼を作ろう (2011) (2)
Generation of 3D retinal tissue from human pluripotent stem cells using a directed small molecule-based serum-free microwell platform (2022) (2)
Developing stem cell therapy for retinal dystrophies (2015) (2)
Retinal Repair In The Degenerating Retina: Assessing Photoreceptor Transplantation In Models Of Retinal Disease (2011) (2)
Visual evoked potentials in ON-pathway disorders (2015) (2)
A molecular and cellular analysis of human embryonic optic fissure closure related to the eye malformation coloboma. (2020) (1)
Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution (2022) (1)
A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness, identifies the gene for Usher syndrome type 1C. (2000) (1)
Temporal and spatial expression patterns of the CRX gene and its downstream targets:critical differences during human and mouse eye development (2001) (1)
Monitoring ferumoxide-labelled neural progenitor cells and lesion evolution by magnetic resonance imaging in a model of cell transplantation in cerebral ischaemia. (2013) (1)
Enhanced Integration of Transplanted Photoreceptor Precursors Following Molecular and Genetic Disruption of the Outer Limiting Membrane (2008) (1)
Spectrum of Mutations in NDP Resulting in Ocular Disease; a Systematic Review (2022) (1)
Restoring Vision to the Blind: Endogenous Regeneration (2014) (1)
Expression of the CRX gene in human retina during early eye development. (2001) (1)
Immune Responses Affect the Survival of Integrated Photoreceptor Precursors Transplanted to the Adult Murine Retina (2010) (1)
The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention (2022) (1)
Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential and conserved mediator of epithelial fusion during vertebrate embryogenesis (2018) (1)
Analysis of PITX2 mutations reveals thresholds of PITX2 activity associated with anterior segment dysgenesis (2004) (0)
Comparative Analysis of Neural Stem Cells Isolated From the Iris, Pars Plana and Ciliary Body of the Porcine Eye (2007) (0)
Towards a cell therapy for retinal disease (2012) (0)
Sclerocornea and cornea plana are distinct entities - Reply (2007) (0)
Reply. (2020) (0)
Kinetics of Rod Photoreceptor Precursor Integration Following Transplantation in the Adult Mouse Retina (2007) (0)
Embryonic stem cell-derived retinal cells transplanted to the adult retina (2011) (0)
14-P021 The role of gliosis and extracellular matrix proteins in rod photoreceptor precursor transplantation in the degenerating retina (2009) (0)
Functional Analysis of FOXE3 Mutations Causing Dominant and Recessive Anterior Segment Disease (2011) (0)
Generation of New Cone and Rod Photoreceptors in the Adult Retina by Transplantation of Crx-Positive Precursor Cells (2009) (0)
Stem Cell Repor ts Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution (2022) (0)
Birth Defects Affecting the Eye (2010) (0)
Retinal repair by photoreceptor precursor transplantation (2010) (0)
A novel syndrome characterized by hypothalamic hormonal insufficiency, neonatal seizures, congenital abnormalities of the kidneys and urinary tract and obesity due to mutation in a gene regulating hypothalamic development (2012) (0)
Typical Coloboma in the UK: A Population Based Study (2009) (0)
Transplantation Of Es Cell-derived Retinal Cells Into The Adult Retina (2012) (0)
Barriers to Integration of Transplanted Photoreceptor Precursors: Gliosis in Crb1rd8/rd8 and Rho-/- Mouse Models of Retinal Degeneration (2009) (0)
Isolating and characterising human cone photoreceptors from pluripotent stem cell cultures (2015) (0)
Digenic Inheritance Of Mutations In FOXC1 And PITX2 Causes Severe Anterior Segment Dysgenesis (2011) (0)
Identification of PITX2 Mutations in Axenfeld-Rieger Syndrome Patients (2002) (0)
The T transcription factor functions as a dimer and exhibits a common polymorphism in the conserved DNA binding domain of the human protein (1998) (0)
Modelling Photoreceptor Development Using Embryonic Stem Cell-derived 3D Retinal Cultures (2012) (0)
Transplantation of Photoreceptor Precursors Embryonic Stem Cell-Derived Self-Forming Retina (2018) (0)
Effect of FePro- and Endorem-labelling on rat ST14A neural progenitor cell and neurosphere viability and growth in response to ischaemia in vitro (2013) (0)
Contents continued (2001) (0)
Atypical Peters plus syndrome with new associations. (2010) (0)
Characterisation Of Gliosis In Different Models Of Retinitis Pigmentosa (2011) (0)
Gliosis and Extracellular Matrix Proteins: Their Role in Rod Photoreceptor Transplantation in the Degenerating Retina (2010) (0)
Chapter 5 - Restoring Vision to the Blind: Endogenous Regeneration. (2014) (0)
Chx10 as a regulator of retinal stem cells (2004) (0)
Generation of New Cone and Rod Photoreceptors in Models of Retinal Degeneration by Transplantation of Crx-Positive Precursor Cells (2010) (0)
The Visual System (2016) (0)
Lack of Chx10 causes embryonic retinal progenitors to persist in the adult retina (2004) (0)
Time-course And Characterisation Of Transplanted Photoreceptor Precursor Migration And Maturation (2012) (0)
Rat neurosphere response to cerebral ischaemia (2013) (0)
Progress Determining the Mechanism of Segmental Duplication and Deletion in Axenfeld Rieger Phenotypes (2007) (0)
Analysis of eye development in mice with a targeted mutation of the Tbx2 gene. (2005) (0)
A recessive contiguous gene syndrome identifies the type 1C Usher gene (2000) (0)
Are motion coherence thresholds in individuals with autism spectrum disorder associated with retinal function (2019) (0)
Photoreceptor development is delayed and disrupted in the ocular retardation mouse retina (2000) (0)
Congenital Eye Anomalies: An Epidemiological Study in the United Kingdom (2009) (0)
Restoring Vision to the Blind : Endogenous Regeneration The Lasker / IRRF Initiative for Innovation in Vision Science Discussion Leaders : (2014) (0)
Isolating and characterising human cone photoreceptors for cell therapy (2016) (0)
Investigation of the role of the EFEMP1 gene in the developing retina and retina disease (2001) (0)
Kinetics of Integration Following Transplantation of Photoreceptor Precursors Into Adult Mice (2010) (0)
Paired interstitial duplications and deletions: a novel cause of ocular developmental abnormalities and glaucoma (2001) (0)
Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision (2019) (0)
CHRDL1 Mutations Cause X-linked Megalocornea and Reveal an Unexpected Role for the Encoded Protein Ventroptin in Anterior Segment Development (2012) (0)
Towards Photoreceptor Replacement Therapy: Identifying The Cell Surface Marker Profile Of Photoreceptor Precursors (2012) (0)
The Oculome: a genetic test to diagnose a diverse range of ocular birth anomalies (2017) (0)
Photoreceptor Transplantation In The Degenerating Retina: Breadth Of Application And Manipulation Of The Microenvironment To Enhance Efficiency (2012) (0)
An Investigation of the Developmental Glaucoma Genes as Genetic Risk Factors in Ocular Hypertension and Primary Open Angle Glaucoma (2008) (0)
Overexpression of developmentally regulated neurotrophins in the adult mouse retina to facilitate integration of transplanted photoreceptor precursor cells (2008) (0)
Isolated congenital superior oblique paresis: a high-resolution MRI phenotype/genotype study (2014) (0)
The Outer Limiting Membrane as a Barrier to Photoreceptor Integration, After Transplantation to the Subretinal Space of the Adult Mouse (2007) (0)
Progress with FOXC1 gene dosage. (2001) (0)
Immature neural retinal cells integrate and differentiate into photoreceptors when transplanted into the mouse subreitnal space at post-natal day 1 (2005) (0)
Transcriptome Analysis Of Crx-expressing Photoreceptor Precursor Cells For Photoreceptor Cell Replacement Therapy (2011) (0)
The Expression Pattern of the Ush1C Protein in the Mouse Eye Suggests Differences in Usher Type 1 Multi Protein Complex Formation Between the Ear and the Eye (2003) (0)
The Adult Retinal Environment Favours New Rod Cell Integration And Limits Cone Cell Differentiation Following Transplantation Of Crx.gfp Precursor Cells (2011) (0)

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University College London

Jane Sowden's Academic­Influence.com Rankings

Why Is Jane Sowden Influential?

Jane Sowden's Published Works

Published Works

Other Resources About Jane Sowden

What Schools Are Affiliated With Jane Sowden?

Jane Sowden's AcademicInfluence.com Rankings