Jane Clarke
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English biochemist and academic
Jane Clarke 's AcademicInfluence.com Rankings
Jane Clarke biology Degrees
Biology
#4493
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#6692
Historical Rank
Biochemistry
#2428
World Rank
#2582
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Biology
Jane Clarke 's Degrees
- Bachelors Biochemistry University of Oxford
Why Is Jane Clarke Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jane Clarke is an English biochemist and academic. Since October 2017, she has served as President of Wolfson College, Cambridge. She is also Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow in the Department of Chemistry at the University of Cambridge. She was previously a Fellow of Trinity Hall, Cambridge. In 2023, she was elected to the National Academy of Sciences.
Jane Clarke 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanical and chemical unfolding of a single protein: a comparison. (1999) (954)
- Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation. (1993) (329)
- The folding and evolution of multidomain proteins (2007) (314)
- The importance of sequence diversity in the aggregation and evolution of proteins (2005) (307)
- Single-molecule studies of protein folding. (2008) (302)
- Atomic force microscopy reveals the mechanical design of a modular protein. (2000) (261)
- Hidden complexity in the mechanical properties of titin (2003) (259)
- Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors (2015) (236)
- The structure of a PKD domain from polycystin‐1: implications for polycystic kidney disease (1999) (225)
- Can non-mechanical proteins withstand force? Stretching barnase by atomic force microscopy and molecular dynamics simulation. (2001) (223)
- Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering. (2002) (195)
- Folding studies of immunoglobulin-like beta-sandwich proteins suggest that they share a common folding pathway. (1999) (191)
- Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state. (2001) (181)
- The folding of an immunoglobulin-like Greek key protein is defined by a common-core nucleus and regions constrained by topology. (2000) (175)
- Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins (2011) (167)
- Mechanical unfolding of a titin Ig domain: structure of transition state revealed by combining atomic force microscopy, protein engineering and molecular dynamics simulations. (2003) (165)
- Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding. (2000) (159)
- Parallel protein-unfolding pathways revealed and mapped (2003) (155)
- Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein (2014) (129)
- Experimental evidence for a frustrated energy landscape in a 3-helix bundle protein family (2009) (129)
- Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies* (2016) (122)
- Folding and Binding of an Intrinsically Disordered Protein: Fast, but Not ‘Diffusion-Limited’ (2013) (119)
- Force mode atomic force microscopy as a tool for protein folding studies (2003) (118)
- Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (2017) (113)
- Hydrogen exchange and protein folding. (1998) (112)
- Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: description of the folding pathway. (1997) (112)
- Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy (2012) (112)
- The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction. (2005) (112)
- Mechanical unfolding of TNfn3: the unfolding pathway of a fnIII domain probed by protein engineering, AFM and MD simulation. (2005) (111)
- Versatile cloning system for construction of multimeric proteins for use in atomic force microscopy (2002) (108)
- An evaluation of the use of hydrogen exchange at equilibrium to probe intermediates on the protein folding pathway. (1996) (107)
- Mechanical unfolding of proteins: insights into biology, structure and folding. (2007) (104)
- Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure (2014) (101)
- Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac. (2000) (99)
- Folding and stability of a fibronectin type III domain of human tenascin. (1997) (99)
- Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP). (2011) (98)
- Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily. (2002) (98)
- The folding nucleus of a fibronectin type III domain is composed of core residues of the immunoglobulin-like fold. (2001) (94)
- Titin; a multidomain protein that behaves as the sum of its parts. (2002) (89)
- A simple method for probing the mechanical unfolding pathway of proteins in detail (2002) (89)
- Transient misfolding dominates multidomain protein folding (2015) (84)
- Atomic force microscopy: mechanical unfolding of proteins. (2004) (83)
- The effect of boundary selection on the stability and folding of the third fibronectin type III domain from human tenascin. (1998) (82)
- Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX (2013) (82)
- Cotranslational folding of spectrin domains via partially structured states (2017) (81)
- Staphylococcal biofilm-forming protein has a contiguous rod-like structure (2012) (80)
- Two proteins with the same structure respond very differently to mutation: the role of plasticity in protein stability. (2000) (79)
- What contributions to protein side-chain dynamics are probed by NMR experiments? A molecular dynamics simulation analysis. (2005) (78)
- De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints (2016) (78)
- Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants (2014) (73)
- Folding of beta‐sandwich proteins: Three‐state transition of a fibronectin type III module (2008) (71)
- Studying the folding of multidomain proteins (2008) (71)
- Folding pathway of an Ig domain is conserved on and off the ribosome (2018) (70)
- Designing an extracellular matrix protein with enhanced mechanical stability (2007) (69)
- Relationship between equilibrium amide proton exchange behavior and the folding pathway of barnase. (1995) (69)
- The folding of spectrin domains I: wild-type domains have the same stability but very different kinetic properties. (2004) (64)
- Evolution of oligomeric state through allosteric pathways that mimic ligand binding (2014) (62)
- Plasticity Within the Obligatory Folding Nucleus of an Immunoglobulin-like Domain (2008) (62)
- The folding of spectrin domains II: phi-value analysis of R16. (2004) (62)
- Cooperative folding in a multi-domain protein. (2005) (61)
- Spectrin domains lose cooperativity in forced unfolding. (2007) (60)
- BPPred: A Web‐based computational tool for predicting biophysical parameters of proteins (2006) (58)
- What lessons can be learned from studying the folding of homologous proteins? (2010) (57)
- Complex folding kinetics of a multidomain protein. (2006) (56)
- Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways? (1997) (55)
- What can atomic force microscopy tell us about protein folding? (2002) (53)
- Apparent cooperativity in the folding of multidomain proteins depends on the relative rates of folding of the constituent domains (2006) (52)
- Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans. (1996) (52)
- Self-consistent determination of the transition state for protein folding: Application to a fibronectin type III domain (2003) (51)
- The effects of disulfide bonds on the denatured state of barnase (2000) (50)
- The folding pathway of spectrin R17 from experiment and simulation: using experimentally validated MD simulations to characterize States hinted at by experiment. (2006) (50)
- Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure (2017) (50)
- Comparison of the transition states for folding of two Ig-like proteins from different superfamilies. (2004) (49)
- The origin of protein sidechain order parameter distributions. (2004) (49)
- Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways. (1993) (48)
- Disulfide mutants of barnase. I: Changes in stability and structure assessed by biophysical methods and X-ray crystallography. (1995) (47)
- Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein (2015) (46)
- Different Members of a Simple Three-Helix Bundle Protein Family Have Very Different Folding Rate Constants and Fold by Different Mechanisms (2009) (39)
- Spectrin R16: Broad energy barrier or sequential transition states? (2005) (39)
- Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains (2012) (37)
- Take home lessons from studies of related proteins (2013) (37)
- Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex (2017) (37)
- Hydrophobic core fluidity of homologous protein domains: relation of side-chain dynamics to core composition and packing. (2004) (37)
- A Mechanistic Model for Amorphous Protein Aggregation of Immunoglobulin-like Domains (2013) (36)
- Slow, reversible, coupled folding and binding of the spectrin tetramerization domain. (2012) (35)
- Using Model Proteins to Quantify the Effects of Pathogenic Mutations in Ig-like Proteins*♦ (2006) (35)
- pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions (2017) (34)
- Folding intermediates of wild-type and mutants of barnase. II. Correlation of changes in equilibrium amide exchange kinetics with the population of the folding intermediate. (1998) (33)
- Thermodynamics of denaturation of mutants of barnase with disulfide crosslinks. (1997) (32)
- Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins (2018) (31)
- Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1 (2017) (31)
- Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains (2009) (31)
- Folding of a LysM Domain: Entropy-Enthalpy Compensation in the Transition State of an Ideal Two-state Folder (2008) (30)
- Biophysical investigations of engineered polyproteins: implications for force data. (2005) (30)
- Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners (2013) (29)
- Membrane protein folding makes the transition (2010) (28)
- The Folding Pathway of a Single Domain in a Multidomain Protein is not Affected by Its Neighbouring Domain (2008) (28)
- Thermodynamic characterisation of two transition states along parallel protein folding pathways. (2004) (28)
- Disorder drives cooperative folding in a multidomain protein (2016) (26)
- Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains* (2009) (26)
- An Effective Strategy for the Design of Proteins with Enhanced Mechanical Stability** (2008) (25)
- Topology is the Principal Determinant in the Folding of a Complex All-alpha Greek Key Death Domain from Human FADD (2009) (25)
- Disulfide mutants of barnase. II: Changes in structure and local stability identified by hydrogen exchange. (1995) (25)
- Crosstalk between the Protein Surface and Hydrophobic Core in a Core-swapped Fibronectin Type III Domain (2008) (24)
- GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins. (2016) (23)
- Characterisation of urea-denatured states of an immunoglobulin superfamily domain by heteronuclear NMR. (1998) (23)
- The dependence of chemical exchange on boundary selection in a fibronectin type III domain from human tenascin. (1998) (22)
- Extrinsic conditions influence the self-association and structure of IF1, the regulatory protein of mitochondrial ATP synthase (2019) (21)
- The importance of loop length in the folding of an immunoglobulin domain. (2004) (20)
- Investigating the Effect of Chain Connectivity on the Folding of a Beta-Sheet Protein On and Off the Ribosome (2018) (18)
- Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex (2017) (18)
- Structural comparison of the two alternative transition states for folding of TI I27. (2006) (18)
- Distinguishing specific and nonspecific interdomain interactions in multidomain proteins. (2008) (17)
- A reply to Englander and Woodward (1998) (16)
- Adaptation of Proteins to the Cold in Antarctic Fish: A Role for Methionine? (2018) (16)
- Promiscuous and Selective: How Intrinsically Disordered BH3 Proteins Interact with Their Pro-survival Partner MCL-1. (2018) (16)
- Protein Folding: Adding a Nucleus to Guide Helix Docking Reduces Landscape Roughness (2012) (14)
- Non-Native Cooperative Interactions Modulate Protein Folding Rates. (2018) (14)
- Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low' {Phi}-values. (2008) (14)
- Experiments Suggest that Simulations May Overestimate Electrostatic Contributions to the Mechanical Stability of a Fibronectin Type III Domain (2007) (13)
- The folding and unfolding behavior of ribonuclease H on the ribosome (2020) (12)
- Single molecule studies of protein folding using atomic force microscopy. (2007) (12)
- Two Immunoglobulin Tandem Proteins with a Linking β-Strand Reveal Unexpected Differences in Cooperativity and Folding Pathways (2012) (10)
- Biophysics: Rough passage across a barrier (2013) (9)
- Unfolding Induced by Mechanical Force (2008) (8)
- Folding and binding — new technologies and new perspectives (2003) (8)
- The Folding of a Family of Three-Helix Bundle Proteins: Spectrin R15 Has a Robust Folding Nucleus, Unlike Its Homologous Neighbours☆ (2014) (8)
- Manipulating the stability of fibronectin type III domains by protein engineering (2008) (7)
- Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins – studies of isolated domains are not enough (2013) (7)
- Protein engineering and design: from first principles to new technologies. (2010) (6)
- Folding and binding Emerging themes in protein folding and assembly (2001) (5)
- The Response of Greek Key Proteins to Changes in Connectivity Depends on the Nature of Their Secondary Structure (2015) (5)
- The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome (2018) (5)
- Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins (2016) (4)
- Editorial overview: Protein Folding and Binding, Complexity Comes of Age. (2017) (4)
- FnIII domains: predicting mechanical stability. (2004) (4)
- Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (2018) (4)
- Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs (2019) (3)
- Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs** (2020) (3)
- Mechanisms of Folding upon Binding (2015) (2)
- Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry (2020) (2)
- Conserved helix-flanking prolines modulate IDP:target affinity by altering the lifetime of the bound complex (2017) (1)
- Spontaneous oligomerization of BAK/BAX is suppressed by hetero-dimerization with MCL-1 (2019) (1)
- Structure of ancestral PyrR protein (AncGREENPyrR) (2014) (0)
- What Encodes Coupled Folding and Binding Reactions: IDPS or Partner Proteins? (2017) (0)
- Platform: Intrinsically Disordered Proteins (IDP) and Aggregates II (2016) (0)
- Speed Dating with KIX: A Single Domain that has Many Partners (2014) (0)
- Studying the Role of Protein Flexibility in Allosteric and Evolutionary Changes as Seen in PyrR Protein Family (2014) (0)
- Conservation of Folding Mechanism in Cotranslational Folding of Titin I27 (2018) (0)
- Initiation by T 7 R N A Polymerase at Its Natural Promoters 2645 (2001) (0)
- Titin I27: A Protein with a Complex Folding Landscape (2007) (0)
- Surprising Abundance of Misfolding during Refolding of Multidomain Proteins (2015) (0)
- Effect of Chain the Folding of a Beta-Sheet Off the Ribosome (2018) (0)
- Non-native Interactions Explain the Folding Rate Differences in α-Spectrin Domains and the Origin of Internal Friction Effects (2017) (0)
- IDPs that Fold Upon Binding: What is the Role of the Partner Protein? (2015) (0)
- Learning from Nature to design new biomolecules. (2012) (0)
- Structure of PyrR protein from Bacillus subtilis (2014) (0)
- OP-GBEV180265 220..231 (2019) (0)
- Cotranslational folding studies of spectrin and Ig-like domains show folding occurs close to the ribosome (2016) (0)
- Structure of ancestral PyrR protein (AncORANGEPyrR) (2014) (0)
- Paper Alert Chosen by (2000) (0)
- The Folding of SasG: A Long and Remarkably Strong Monomeric Protein Responsible for Biofilm Formation is a Highly Cooperative System (2015) (0)
- Single Protein Mechanics Studied with Afm Techniques (1999) (0)
- Proteomics-Level Identification of Degradation-Resistant Proteins Provide Insight about their Potential Roles in Organismal Adaptation to Stress (2015) (0)
- folding intermediate of spectrin R16 (2017) (0)
- Plasticity of Nucleoporin Nuclear Transport Receptor Interactions - Molecular Description of a Highly Dynamic, Ultrafast Interaction Mechanism (2016) (0)
- A kinetic study of the interaction of T7 RNA polymerase with its natural promoters (1990) (0)
- Structure of engineered PyrR protein (VIOLET PyrR) (2014) (0)
- The Role of Disorder in Protein Folding (2016) (0)
- THE SLOW-EXCHANGE CORE AND PROTEIN FOLDING. AUTHORS' REPLY (1998) (0)
- Structure of core-swapped mutant of fibronectin (2007) (0)
- Identity of Hinge Residues Defines Stability and Kinetics of Spectrin Tetramer Interaction (2013) (0)
- 1 Disorder drives cooperative folding in a multi-domain protein (2016) (0)
- BARNASE A43C/S80C DISULFIDE MUTANT (1995) (0)
- Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (2017) (0)
- Effect of Transient Helicity of cMyb TAD on its Binding Affinity to the Kix Domain of CBP/p300 (2017) (0)
- Folding Upon Binding - Is it just a Simple Protein Folding Problem? (2014) (0)
- BARNASE T70C/S92C DISULFIDE MUTANT (1995) (0)
- BARNASE S85C/H102C DISULFIDE MUTANT (1995) (0)
- Structure of PyrR protein from Bacillus subtilis with GMP (2014) (0)
- Structure of engineered PyrR protein (PURPLE PyrR) (2014) (0)
- Folding Upon Binding - Not a Simple Protein Folding Problem (2013) (0)
- Structure of ancestral PyrR protein (PLUMPyrR) (2014) (0)
- Basic studies of protein folding and stability: the folding of related protein families (2007) (0)
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