Jane Skok
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Computer Science
Jane Skok's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Mathematics University of California, Berkeley
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Why Is Jane Skok Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jane Skok is the Sandra and Edward H. Meyer Professor of Radiation Oncology at New York University. Biography Skok was born in Johannesburg. She earned a PhD at University College London in immunology and genetics. After completing her PhD, she left science to care for her two children, one of whom was chronically ill.
Jane Skok's Published Works
Published Works
- Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development (2002) (757)
- CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation (2015) (473)
- Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. (2004) (418)
- Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene (2005) (266)
- Yin Yang 1 is a critical regulator of B-cell development. (2007) (255)
- Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes (2001) (226)
- Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. (2008) (204)
- Epigenetic ontogeny of the Igk locus during B cell development (2005) (172)
- Capturing the onset of PRC2-mediated repressive domain formation (2018) (172)
- Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes (2007) (148)
- RNA Interactions Are Essential for CTCF-Mediated Genome Organization. (2019) (141)
- RAG1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci (2009) (139)
- Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms (2015) (134)
- Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. (1999) (120)
- DNA methylation disruption reshapes the hematopoietic differentiation landscape (2020) (115)
- CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci (2016) (107)
- The RAG2 C-terminus suppresses genomic instability and lymphomagenesis (2011) (105)
- 4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments (2016) (85)
- Transcriptional regulation in early B cell development. (2007) (84)
- Association between the Igk and Igh immunoglobulin loci mediated by the 3′ Igk enhancer induces 'decontraction' of the Igh locus in pre–B cells (2008) (80)
- MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. (2016) (79)
- Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. (2017) (72)
- β-Catenin induces T-cell transformation by promoting genomic instability (2013) (64)
- Close proximity to Igh is a contributing factor to AID-mediated translocations. (2012) (63)
- C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. (2004) (62)
- A Multifunctional Element in the Mouse Igκ Locus That Specifies Repertoire and Ig Loci Subnuclear Location (2011) (60)
- Long-Range Regulation of V(D)J Recombination. (2015) (58)
- The pre‐B‐cell receptor induces silencing of VpreB and λ5 transcription (2005) (56)
- The role of CTCF in regulating V(D)J recombination. (2012) (53)
- Chromosome dynamics and the regulation of V(D)J recombination (2010) (51)
- NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains (2019) (47)
- Breaking TADs: insights into hierarchical genome organization. (2015) (46)
- Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions (2016) (44)
- Dynamic Changes in Accessibility, Nuclear Positioning, Recombination, and Transcription at the Igκ Locus12 (2007) (42)
- IL-7 Functionally Segregates the Pro-B Cell Stage by Regulating Transcription of Recombination Mediators across Cell Cycle (2012) (39)
- RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation (2011) (39)
- Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination (2016) (37)
- Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers. (2013) (36)
- B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage (2017) (35)
- The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage (2013) (34)
- The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription. (2005) (33)
- miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. (2016) (33)
- A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination (2016) (33)
- Distinct genes for fibroblast and serum C1q (1981) (31)
- Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate (2018) (31)
- Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation. (2016) (31)
- Combined immunofluorescence and DNA FISH on 3D-preserved interphase nuclei to study changes in 3D nuclear organization. (2013) (30)
- Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool (2001) (29)
- Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development. (2017) (29)
- Equal opportunity for all (2012) (27)
- Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation (2019) (25)
- Control of B-1a cell development by instructive BCR signaling. (2018) (25)
- Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development (2018) (24)
- EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation (2019) (24)
- CTCF and CTCFL in cancer. (2020) (24)
- VH replacement in primary immunoglobulin repertoire diversification (2015) (20)
- A New Take on V(D)J Recombination: Transcription Driven Nuclear and Chromatin Reorganization in Rag-Mediated Cleavage (2013) (20)
- Enhancer talk. (2018) (20)
- Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer. (2021) (19)
- Silencing and Nuclear Repositioning of the λ5 Gene Locus at the Pre-B Cell Stage Requires Aiolos and OBF-1 (2008) (19)
- Addendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci (2010) (17)
- CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters (2022) (16)
- The IgH locus 3′ cis-regulatory super-enhancer co-opts AID for allelic transvection (2017) (14)
- Interpreting 4C-Seq data: how far can we go? (2014) (14)
- The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity. (2013) (13)
- RNA interactions with CTCF are essential for its proper function (2019) (13)
- It takes two (2010) (12)
- Faculty Opinions recommendation of Enhancer redundancy provides phenotypic robustness in mammalian development. (2018) (10)
- Epigenetic regulation of V(D)J recombination. (2010) (8)
- The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK− anaplastic large cell lymphoma by regulating the DNA helicase HELLS (2020) (8)
- Regulation of Th 1 Development FeedbackInduction of Th 2 Differentiation : A Dendritic Cell-Derived IL-12 Promotes B Cell (1999) (7)
- Finding the Right Partner in a 3D Genome (2013) (7)
- Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency (2020) (6)
- Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association (2020) (6)
- Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice (2019) (5)
- The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect (2017) (5)
- Somatic Focal Copy Number Gains of Noncoding Regions of Receptor Tyrosine Kinase Genes in Treatment-Resistant Epilepsy. (2020) (4)
- Cell type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening (2022) (3)
- Response to Casellas et al. (2013) (2)
- Ontogeny and Vulnerabilities of Lapatinib Drug-Tolerant Persisters in HER2+ Breast Cancer (2020) (2)
- NSD2 overexpression drives clustered chromatin and transcriptional changes in insulated domains (2019) (2)
- A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters (2020) (2)
- EpiMethylTag simultaneously detects ATAC-seq or ChIP-seq signals with DNA methylation (2019) (2)
- The Ig heavy chain protein but not its message controls early B cell development (2020) (2)
- Author Correction: Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation (2020) (1)
- LGG-11. LOW-GRADE ASTROCYTOMA CORE MUTATIONS IN IDH1, P53 AND ATRX COOPERATE TO BLOCK DIFFERENTIATION OF HUMAN NEURAL STEM CELLS VIA EPIGENETIC REPRESSION OF SOX2 (2017) (1)
- Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate (2018) (1)
- A Rock Thin Section Device for Space Exploration (2010) (1)
- RAG Off-Target Activity Is in the Loop. (2015) (1)
- Faculty Opinions recommendation of 3D genomics across the tree of life reveals condensin II as a determinant of architecture type. (2021) (1)
- Thin Sections in Planetary Applications (2007) (1)
- The Spaceward Bound Field Training Curriculum for Moon and Mars Analog Environments (2007) (1)
- Cell type-specific prediction of 3 D chromatin architecture 1 (2022) (1)
- Simultaneous Tagmentation-Based Detection of ChIP/ATAC Signal with Bisulfite Sequencing. (2021) (1)
- 21 – Chromatin Folding and Recombination (2018) (1)
- V(D)J recombination: a paradigm for studying chromosome interactions in mammalian cells. (2010) (1)
- Control of RAG Cleavage Activity Contributes to Maintaining Genome Stability During V(D)J Recombination (2011) (0)
- Faculty Opinions recommendation of Ultraconserved enhancer function does not require perfect sequence conservation. (2021) (0)
- Nuclear Organisation of Immunoglobulin Genes (2002) (0)
- CRISPR-Decryptr reveals cis-regulatory elements from noncoding perturbation screens (2020) (0)
- Corrigendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci (2010) (0)
- Editorial overview: Understanding the biology of cancer genomes in the context of DNA, RNA, histone marks, and 3D chromatin organization. (2022) (0)
- Returning to the lab after a career break (2022) (0)
- The pre-B-cell receptor induces silencing of VpreB and k 5 transcription (2005) (0)
- Recombination Mediators across Cell Cycle Stage by Regulating Transcription of IL-7 Functionally Segregates the Pro-B Cell (2012) (0)
- Faculty Opinions recommendation of CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains. (2021) (0)
- A Damage-Independent Ro le for 53 BP 1 that Impacts Break Order and Igh Architecture during Class Switch Recombination Graphical (2016) (0)
- Taking a break from the lab: can it really be done? (2014) (0)
- Locus That Specifies Repertoire and Ig A Multifunctional Element in the Mouse (2011) (0)
- Faculty Opinions recommendation of Genetic and spatial organization of the unusual chromosomes of the dinoflagellate Symbiodinium microadriaticum. (2021) (0)
- Target-specific synthetic oligonucleotide libraries for use in Fluorescent In Situ Hybridization (2014) (0)
- Corrigendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci (2009) (0)
- The interdependent nature of multi-loci associations can be revealed by 4C-Seq (2015) (0)
- Mediators across Cell Cycle by Regulating Transcription of Recombination IL-7 Functionally Segregates the ProB Cell Stage Data (2012) (0)
- EPCO-19. ADAPTIVE RESPONSES TO GENOME-WIDE DNA DAMAGE RESULT IN TOPOLOGIC GENOME REORGANIZATION IN GLIOBLASTOMA (2022) (0)
- Genetic rearrangements (VDJ/CSR/SHM) (WS-080) Chairpersons: Ji-Yang Wang, Satoshi Takaki (2010) (0)
- Faculty Opinions recommendation of Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. (2018) (0)
- Viral infection alters subnuclear localization of PD-1 and CD62L loci in LCMV-specific CD8 T-cells (P6369) (2013) (0)
- Identification of new therapeutic targets in CRLF2-overexpressing B-ALL through discovery of TF-gene regulatory interactions (2020) (0)
- Correction for Zhou et al., Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association (2021) (0)
- Author Correction: Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation (2020) (0)
- STEM-17. LOW GRADE ASTROCYTOMA MUTATIONS COOPERATE TO DISRUPT SOX2 GENOMIC ARCHITECTURE AND BLOCK DIFFERENTIATION VIA PREVIOUSLY UNIDENTIFIED ENHANCER ELEMENTS (2019) (0)
- CBIO-05. SOX2 CHROMATIN ARCHITECTURE AND ENHANCER ACTIVITY IN THE MAINTENANCE AND DEVELOPMENT OF NEURAL STEM CELLS (2021) (0)
- Regulation of Igh Recombination and Allelic Exclusion (2016) (0)
- Coordinated regulation of PD-1 gene expression and nuclear localization during virus-specific memory CD8+ T cell differentiation (154.20) (2011) (0)
- After a decade-long hiatus from science, Jane Skok returned to the lab to study the mechanism that allows each B cell to secrete antibodies that recognize only one target. Jane Skok: Choreography of allelic exclusion (2008) (0)
- Faculty Opinions recommendation of Transposable elements drive widespread expression of oncogenes in human cancers. (2019) (0)
- Faculty Opinions recommendation of Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. (2018) (0)
- Faculty Opinions recommendation of The structural basis for cohesin-CTCF-anchored loops. (2020) (0)
- A B-cell acute lymphoblastic leukemia regulatory network defines novel therapeutic targets inIGH-CRLF2patients (2019) (0)
- [Methods and epidemiologic usefulness of prophylactic testing for gonorrhea in women]. (1976) (0)
- Immunoglobulin loci undergo lineage-specific subnuclear compartmentalisation (2002) (0)
- revealed by 4C-Seq (2015) (0)
- Rag1D600A, a novel catalytically inactive RAG mouse model (2019) (0)
- ! 1 ! The interdependent nature of multi-loci associations can be revealed by 4 C-Seq (2015) (0)
- Editorial: From chromatin to dynamic loops and liquid-like phases: New views on the cell nucleus. (2021) (0)
- The Impact of Nuclear Organization and Homolgous Recombination in Repair of DNA Damage Introduced By Aid during Class Switch Recombination (2014) (0)
- Necessary for Correct Hematopoietic and B Cell Development Graphical Abstract Highlights (2017) (0)
- Faculty Opinions recommendation of Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion. (2020) (0)
- Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation (2020) (0)
- The impact of endogenous retroviruses on nuclear organization and gene expression (2018) (0)
- Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development (2018) (0)
- Jane Skok: choreography of allelic exclusion. [Interview by Hema Bashyam]. (2008) (0)
- SOX2-phosphorylation toggles a bistable differentiation-switch in squamous cell carcinoma (2021) (0)
- Dysregulation of Epigenetic Landscape Uncovered the Mechanisms Underlying the Relapse of Pediatric Acute Lymphoblastic Leukemia with NSD2 Mutation (2021) (0)
- Faculty Opinions recommendation of ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms. (2020) (0)
- miRNAs are critical for the regulation of RAG expression and secondary Ig rearrangement in peripheral B lymphocytes (2016) (0)
- Abstract 3622: DNA damage drives DNA methylation and 3D chromatin organization alterations in glioblastoma (2022) (0)
- EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation (2019) (0)
- CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters (2022) (0)
- The art of chromosome dynamics: an interview with Jane Skok. (2022) (0)
- DNA methylation disruption reshapes the hematopoietic differentiation landscape (2020) (0)
- Faculty Opinions recommendation of Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes. (2020) (0)
- How can the RAG proteins synapse V and D segments that are so far apart ? (2010) (0)
- Faculty Opinions recommendation of DNA loop extrusion by human cohesin. (2019) (0)
- Faculty Opinions recommendation of Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding. (2020) (0)
- Faculty Opinions recommendation of Extensive heterogeneity and intrinsic variation in spatial genome organization. (2019) (0)
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