Jason Micklefield | Academic Influence

Jason Micklefield's AcademicInfluence.com Rankings

Jason Micklefield

Computer Science

#11741

World Rank

#12488

Historical Rank

Machine Learning

#5400

World Rank

#5471

Historical Rank

Artificial Intelligence

#5824

World Rank

#5913

Historical Rank

Database

#8830

World Rank

#9274

Historical Rank

computer-science Degrees

Download Badge

Computer Science

Jason Micklefield's Degrees

Bachelors Computer Science University of Oxford

Similar Degrees You Can Earn

Why Is Jason Micklefield Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Jason Micklefield is a British Biochemist and a professor in the Department of Chemistry at The University of Manchester. His research involves the discovery, characterisation and engineering of biosynthetic pathways to new bioactive natural products, particularly antibiotics. He is also interested in the discovery, structure, mechanism and engineering of enzymes for synthetic applications, including the integration of enzymes with chemocatalysis for telescoping routes to pharmaceuticals and other valuable products.

(See a Problem?)

Jason Micklefield's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
Selective covalent protein immobilization: strategies and applications. (2009) (417)
S‐Adenosyl‐Methionine‐Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications (2012) (265)
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. (2002) (210)
Mining and engineering natural-product biosynthetic pathways. (2007) (193)
Recent advances in engineering nonribosomal peptide assembly lines. (2016) (172)
Development of Halogenase Enzymes for Use in Synthesis. (2018) (167)
Backbone modification of nucleic acids: synthesis, structure and therapeutic applications. (2001) (161)
Reengineering orthogonally selective riboswitches (2010) (147)
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals (2018) (127)
Chemical Modification of Oligonucleotides for Therapeutic, Bioanalytical and other Applications (2009) (99)
Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation (2016) (99)
Direct site-selective covalent protein immobilization catalyzed by a phosphopantetheinyl transferase. (2008) (97)
NMR structure determination and calcium binding effects of lipopeptide antibiotic daptomycin. (2004) (93)
Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity. (2012) (92)
Parallel scanning near-field photolithography: the snomipede. (2010) (75)
Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. (2007) (74)
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00913h (2015) (72)
Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species. (2014) (66)
A Structure‐Guided Switch in the Regioselectivity of a Tryptophan Halogenase (2016) (62)
Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides. (2006) (62)
Cellular targets of natural products. (2007) (59)
Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases. (2009) (56)
Recent advances in methyltransferase biocatalysis. (2017) (55)
Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates. (2004) (54)
Subsurface biomolecular imaging of Streptomyces coelicolor using secondary ion mass spectrometry. (2008) (50)
Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor. (2004) (47)
Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. (2016) (45)
Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase (2016) (43)
RadH: A Versatile Halogenase for Integration into Synthetic Pathways (2017) (43)
Orthogonal riboswitches for tuneable coexpression in bacteria. (2012) (43)
A dynamic combinatorial screen for novel imine reductase activity (2004) (41)
Engineered biosynthesis of nonribosomal lipopeptides with modified fatty acid side chains. (2007) (39)
Protein micro- and nanopatterning using aminosilanes with protein-resistant photolabile protecting groups. (2011) (38)
Structure and mechanism of an unusual malonate decarboxylase and related racemases. (2008) (37)
Daptomycin structure and mechanism of action revealed. (2004) (37)
Engineering enzymatic assembly lines to produce new antibiotics (2019) (36)
Thermal bifunctionality of bacterial phenylalanine aminomutase and ammonia lyase enzymes. (2012) (36)
An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium-dependent lipopeptide antibiotics. (2007) (35)
Dual transcriptional-translational cascade permits cellular level tuneable expression control (2015) (35)
An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins. (2016) (33)
Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00164a (2015) (31)
Micrometer- and nanometer-scale photopatterning using 2-nitrophenylpropyloxycarbonyl-protected aminosiloxane monolayers. (2009) (31)
Unusual RNA and DNA binding properties of a novel pyrrolidine–amide oligonucleotide mimic (POM) (2000) (30)
Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch. (2015) (30)
Bioengineering natural product biosynthetic pathways for therapeutic applications. (2012) (30)
Biotransformations in low-boiling hydrofluorocarbon solvents. (2004) (30)
Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers (2020) (29)
Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. (2007) (29)
Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. (2012) (27)
De novo Biosynthesis of “Non‐Natural” Thaxtomin Phytotoxins (2018) (26)
Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues. (2008) (23)
Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase (2018) (23)
Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli (2019) (23)
A methodology for preparing nanostructured biomolecular interfaces with high enzymatic activity. (2012) (21)
Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol (2020) (21)
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. (2011) (21)
Stereochemical course of tryptophan dehydrogenation during biosynthesis of the calcium-dependent lipopeptide antibiotics. (2007) (20)
Synthesis and nucleic-acid-binding properties of sulfamide- and 3′-N-sulfamate-modified DNA (2002) (20)
The optimisation of sorption sensor arrays for use in ambient conditions (1998) (20)
Programmable late-stage C−H bond functionalization enabled by integration of enzymes with chemocatalysis (2021) (19)
The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00717a (2018) (19)
Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29 (2015) (17)
A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone–Amine Coupling with Applications in the Screening of Enzymatic Halogenations (2014) (17)
NMR confirmation that tryptophan dehydrogenation occurs with syn stereochemistry during the biosynthesis of CDA in Streptomyces coelicolor. (2007) (17)
Harnessing and engineering amide bond forming ligases for the synthesis of amides. (2020) (17)
Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways (2020) (17)
Chapter 14. Biosynthesis of nonribosomal peptide precursors. (2009) (17)
Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM). (2003) (17)
An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β‐Methyltryptophan and Derivatives (2017) (17)
A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of α,β-Epoxyketone Proteasome Inhibitors. (2016) (17)
Reagents for carbonyl methylenation in organic synthesis (2005) (16)
Site-selective immobilisation of functional enzymes on to polystyrene nanoparticles. (2010) (16)
Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties. (2007) (16)
Active site modification of the β-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides. (2011) (13)
Haem d1: Stereoselective synthesis of the macrocycle to establish its absolute configuration as 2R,7R (1997) (13)
Merging enzymes with chemocatalysis for amide bond synthesis (2022) (12)
Gene editing enables rapid engineering of complex antibiotic assembly lines (2021) (12)
Discovery, characterization and engineering of ligases for amide synthesis (2021) (11)
A vitamin K-dependent carboxylase orthologue is involved in antibiotic biosynthesis (2018) (11)
Real‐Time Monitoring of Enzyme‐Catalysed Reactions using Deep UV Resonance Raman Spectroscopy (2017) (11)
Haem d1: development of a new coupling procedureleading to the synthesis of isobacteriochlorins1 (1997) (11)
Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM). (2004) (10)
Enzymatic Enantioselective Decarboxylative Protonation of Heteroaryl Malonates (2015) (10)
New reaction pathways by integrating chemo- and biocatalysis (2022) (10)
Nanoscale biomolecular structures on self-assembled monolayers generated from modular pegylated disulfides. (2010) (10)
Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties. (2007) (10)
SYNBIOCHEM–a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals (2016) (9)
Sulfamide replacement of the phosphodiester linkage in dinucleotides: Synthesis and conformational analysis (1998) (9)
Lipase-catalysed kinetic resolutions of secondary alcohols in pressurised liquid hydrofluorocarbons (2009) (9)
A non-enzymatic, DNA template-directed morpholino primer extension approach. (2010) (8)
Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block. (2015) (8)
RNA-selective cross-pairing of backbone-extended pyrrolidine-amide oligonucleotide mimics (bePOMs). (2008) (8)
A novel stereoselective synthesis of the macrocycle of haem d1 that establishes its absolute configuration as 2R,7R (1993) (7)
Replacement of the phosphodiester linkage in DNA with sulfamide and 3′-N-sulfamate groups (2000) (7)
Rewiring Riboswitches to Create New Genetic Circuits in Bacteria. (2016) (7)
Synthesis of sulfamide linked dinucleotide analogues (1997) (6)
Biosynthesis and biosynthetic engineering of calcium-dependent lipopeptide antibiotics (2009) (5)
Nucleic acids: new life, new materials. (2013) (5)
Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics. (2011) (5)
Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM). (2006) (5)
The Snomipede: A parallel platform for scanning near-field photolithography (2011) (5)
Generation of orthogonally selective bacterial riboswitches by targeted mutagenesis and in vivo screening. (2014) (5)
Stereochemical course of malonate decarboxylation in Malonomonas rubra (1995) (5)
From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy. (2017) (4)
Streamlined recycling of S-adenosylmethionine (2019) (4)
KINETICALLY SELECTIVE BINDING OF SINGLE STRANDED RNA OVER DNA BY A PYRROLIDINE-AMIDE OLIGONUCLEOTIDE MIMIC (POM) (2001) (3)
Combinatorial biosynthesis of nonribosomal lipopeptides (2008) (3)
7.19 C–X Bond Formation: Enzymatic Enantioselective Decarboxylative Protonation and C–C Bond Formation (2012) (2)
Alkylation and acylation of 5-phenylsulphonyl- and 5-cyanobutyrolactones (1992) (2)
Structure and Biocatalytic Scope of Coclaurine N ‐Methyltransferase (2018) (2)
Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus (2021) (2)
Enzymatic Carboxylation and Decarboxylation. (2014) (2)
SYNBIOCHEM Design-Build-Test-Learn pipeline (2018) (1)
Nature's protection racket. (2005) (1)
Haem d1: Development of a New Coupling Procedure Leading to the Synthesis of Isobacteriochlorins. (2010) (1)
Micrometer- and Nanometer-Scale Photopatterning Using 2-Nitrophenylpropxylcarbonyl-protected aminosiloxane (2009) (1)
Application of phosphopantetheinyl transferase catalyzed site-selective covalent protein immobilization on to nanofabricated surfaces (2009) (0)
Daptomycin NMR Structure (2004) (0)
Crystal structure of arylmalonate decarboxylase (AMDase) from Bordatella bronchiseptic in complex with benzylphosphonate (2009) (0)
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals (2018) (0)
SYNBIOCHEM - Combinatorial plasmid libraries for material monomer production in Escherichia coli. (2019) (0)
Use of coenzyme A for site-specific immobilisation of recombinant proteins (2007) (0)
Engineering Regiocomplementary Flavin-Dependent Halogenase enzymes (2016) (0)
Merging enzymes with chemocatalysis for amide bond synthesis (2022) (0)
Crystal Structure of Malonate Decarboxylase from Bordatella bronchiseptica (2008) (0)
Selective Covalent Protein Immobilization: Strategies and Applications (2009) (0)
Haem d1: Stereoselective Synthesis of the Macrocycle to Establish Its Absolute Configuration as 2R, 7R. (1997) (0)
Unusual RNA and DNA Binding Properties of a Novel Pyrrolidine—Amide Oligonucleotide Mimic (POM). (2001) (0)
Engineering the biosynthesis of nonribosomal lipopeptide antibiotics (2005) (0)
New Malonate Decarboxylases for Industrial Applications PCT Int. Appl. WO 2009068308 (2008) (0)
Site selective protein immobilisation methodology for generating protein micro- and nanoarrays (2008) (0)
Changing the Selectivity of Biocatalysts (2016) (0)
Alkylation and Acylation of 5‐Phenylsulfonyl‐ and 5‐Cyanobutyrolactones. (1993) (0)
Orthogonal riboswitches as tools for controlling gene expression in bacteria (2011) (0)
Direct, Site-Specific and Covalent Immobilisation of Proteins on to Polystyrene Nanoparticles Mediated by a Phosphopantetheinyl Transferase (2008) (0)
A synthesis of haem d (1993) (0)
Solid phase organic synthesis of pegylated disulfides for the generation of biocompatible self-assembled monolayers (2007) (0)
Precursors from Amino Acid Metabolism Nonribosomal peptides (2009) (0)
Cellular Targets of Natural Products (2008) (0)
Synthesis and Nucleic‐Acid‐Binding Properties of Sulfamide‐ and 3′‐N‐Sulfamate‐Modified DNA. (2002) (0)
From multi-step enzyme monitoring to whole-cell biotransformations : development of real-time Ultrav iolet resonance Raman spectroscopy (2017) (0)
Natural products hit the targets other molecules cannot reach (2008) (0)
Nanopatterning by near-field photodeprotection of 2-nitrophenylpropyloxycarbonyl-protected aminosiloxane monolayers on glass (2008) (0)
Editorial overview: Biocatalysis and biotransformations. (2020) (0)
Process for dynamic kinetic resolution (DKR) of racemic compounds in hydrofluorocarbon solvents. PCT Int. Appl. WO 2007129018 (2007) (0)
Replacement of the Phosphodiester Linkage in DNA with Sulfamide and 3′-N-Sulfamate Groups. (2000) (0)
An enzymatic process for the stereoselective production of chemical compounds in fluorocarbon solvents (2004) (0)
Decarboxylases: Enzymatic enantioselective decarboxylative protonation and C-C bond formation (2012) (0)
Fabric solvents procedures for dynamic kinetic resolution (DKR) of racemic compounds in fluoro (hydro) (2007) (0)
Process for dynamic kinetic resolution (rc) of racemic components in solvents (hydro) fluorocarbon. (2007) (0)
Nucleic acid redesign and recognition: the pyrrolidine-amide oligonucleotide mimics (POMs) (2008) (0)
Diversification of Natural and Non-Natural Products Using Engineered Biosynthetic Pathways and Enzymes (2016) (0)

This paper list is powered by the following services:

Other Resources About Jason Micklefield

en.wikipedia.org

What Schools Are Affiliated With Jason Micklefield?

Jason Micklefield is affiliated with the following schools: