Jason McLellan
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American structural biologist
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Jason McLellan's Degrees
- PhD Molecular Biophysics University of Texas at Austin
- Bachelors Biochemistry University of Texas at Austin
Why Is Jason McLellan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jason S. McLellan is a structural biologist, professor in the Department of Molecular Biosciences and Robert A. Welch Chair in Chemistry at The University of Texas at Austin who specializes in understanding the structure and function of viral proteins, including those of coronaviruses. His research focuses on applying structural information to the rational design of vaccines and other therapies for viruses, including SARS-CoV-2, the novel coronavirus that causes COVID-19, and respiratory syncytial virus . McLellan and his team collaborated with researchers at the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center to design a stabilized version of the SARS-CoV-2 spike protein, which biotechnology company Moderna used as the basis for the vaccine mRNA-1273, the first COVID-19 vaccine candidate to enter phase I clinical trials in the U.S. At least three other vaccines use this modified spike protein: those from Pfizer and BioNTech; Johnson & Johnson and Janssen Pharmaceuticals; and Novavax.
Jason McLellan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) (6900)
- Site-specific glycan analysis of the SARS-CoV-2 spike (2020) (1074)
- SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness (2020) (846)
- Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen (2017) (837)
- Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 (2011) (827)
- Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus (2013) (687)
- Pre-fusion structure of a human coronavirus spike protein (2016) (630)
- Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody (2013) (619)
- Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation (2020) (494)
- Immunogenicity of a DNA vaccine candidate for COVID-19 (2020) (492)
- Broad neutralization of SARS-related viruses by human monoclonal antibodies (2020) (464)
- Structure-based design of prefusion-stabilized SARS-CoV-2 spikes (2020) (449)
- Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies (2020) (443)
- Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env-V2 (2012) (431)
- Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis (2018) (421)
- Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes (2020) (407)
- Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein (2020) (385)
- Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. (2013) (381)
- Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes (2011) (319)
- Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera (2015) (275)
- The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates. (2018) (275)
- The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates (2021) (270)
- Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16 (2013) (267)
- Vulnerabilities in coronavirus glycan shields despite extensive glycosylation (2020) (261)
- Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein (2020) (248)
- SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma (2020) (246)
- Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1 (2010) (232)
- Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody (2021) (219)
- Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold (2011) (217)
- A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism (2015) (216)
- Structure and function of respiratory syncytial virus surface glycoproteins. (2013) (213)
- Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset (2014) (210)
- Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4 (2014) (206)
- Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape (2012) (188)
- Adjuvanting a subunit COVID-19 vaccine to induce protective immunity (2021) (188)
- A proof of concept for structure-based vaccine design targeting RSV in humans (2019) (170)
- Structural and molecular basis for Ebola virus neutralization by protective human antibodies (2016) (166)
- Structural basis of respiratory syncytial virus neutralization by motavizumab (2010) (162)
- The mode of Hedgehog binding to Ihog homologs is not conserved across different phyla (2008) (156)
- Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors (2016) (150)
- Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes (2021) (150)
- A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants (2017) (147)
- Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape (2018) (142)
- SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness (2020) (128)
- LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection (2020) (127)
- SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma (2021) (125)
- Respiratory syncytial virus entry and how to block it (2019) (125)
- Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape (2021) (125)
- Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state (2017) (123)
- Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design (2005) (120)
- Prolonged evolution of the human B cell response to SARS-CoV-2 infection (2021) (119)
- Structure-Based Vaccine Antigen Design. (2019) (118)
- Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability (2011) (116)
- Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. (2011) (106)
- Molecular mechanism of respiratory syncytial virus fusion inhibitors. (2016) (106)
- Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F (2010) (106)
- Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein (2015) (105)
- Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies (2013) (104)
- Data publication with the structural biology data grid supports live analysis (2016) (103)
- Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation (2018) (97)
- Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area (2020) (96)
- Structure of a heparin-dependent complex of Hedgehog and Ihog (2006) (95)
- Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection (2014) (94)
- Site-specific analysis of the SARS-CoV-2 glycan shield (2020) (94)
- A glycan gate controls opening of the SARS-CoV-2 spike protein (2021) (91)
- Novel antigens for RSV vaccines. (2015) (91)
- A glycan gate controls opening of the SARS-CoV-2 spike protein (2021) (89)
- Structure of the Respiratory Syncytial Virus Polymerase Complex (2019) (86)
- A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies (2012) (82)
- Respiratory Syncytial Virus Glycoprotein G Interacts with DC-SIGN and L-SIGN To Activate ERK1 and ERK2 (2011) (81)
- Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein. (2015) (79)
- Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle (2012) (75)
- Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis (2018) (73)
- Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein (2017) (71)
- Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate (2011) (69)
- Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD (2019) (69)
- Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. (2007) (69)
- Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies (2020) (69)
- Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex (2017) (67)
- Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate (2015) (59)
- Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state (2017) (57)
- Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines (2021) (56)
- Global site-specific analysis of glycoprotein N-glycan processing (2018) (56)
- Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor (2017) (53)
- Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines (2021) (52)
- Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants (2020) (50)
- Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies (2018) (48)
- The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation (2019) (48)
- Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein (2017) (48)
- Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development. (2017) (47)
- Synthesis of 2,6-dideoxysugars via ring-closing olefinic metathesis. (2002) (47)
- Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma (2020) (46)
- Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions (2021) (46)
- Erratum: Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies (Cell (2020) 181(5) (1004–1015.e15), (S0092867420304943), (10.1016/j.cell.2020.04.031)) (2020) (45)
- Early cross-coronavirus reactive signatures of humoral immunity against COVID-19 (2021) (42)
- N332-Directed Broadly Neutralizing Antibodies Use Diverse Modes of HIV-1 Recognition: Inferences from Heavy-Light Chain Complementation of Function (2013) (41)
- Clinical Potential of Prefusion RSV F-specific Antibodies. (2017) (40)
- A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus (2015) (40)
- Transient opening of trimeric prefusion RSV F proteins (2019) (40)
- Stabilized coronavirus spike stem elicits a broadly protective antibody (2021) (39)
- Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation (2016) (39)
- Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants (2021) (35)
- Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers (2020) (33)
- The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes (2021) (29)
- Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses (2021) (28)
- Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures (2020) (28)
- Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector (2016) (28)
- RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine. (2017) (28)
- Local computational methods to improve the interpretability and analysis of cryo-EM maps (2020) (27)
- Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate (2017) (26)
- Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein (2020) (25)
- Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization (2020) (23)
- Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area (2020) (23)
- Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab (2017) (22)
- Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development (2020) (22)
- Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus (2017) (22)
- Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses. (2021) (22)
- Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape. (2018) (21)
- Alternative conformations of a major antigenic site on RSV F (2019) (21)
- A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants (2021) (21)
- Expression and characterization of SARS-CoV-2 spike proteins (2021) (18)
- Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates (2021) (18)
- Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B (2019) (17)
- Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever (2021) (17)
- Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38 (2020) (17)
- Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas (2020) (17)
- Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures (2020) (16)
- Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition (2021) (16)
- Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens (2020) (16)
- An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19 (2020) (15)
- Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking (2022) (14)
- Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19 (2021) (13)
- Structure and Function of RSV Surface Glycoproteins (2014) (13)
- Antibody-Induced Internalization of the Human Respiratory Syncytial Virus Fusion Protein (2017) (13)
- Rapid development of a synthetic DNA vaccine for COVID-19 (2020) (12)
- Safety and immunogenicity of an inactivated recombinant Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomised, placebo-controlled, phase 1 trial (2022) (12)
- Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic (2021) (12)
- Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step (2020) (12)
- Effects of COVID-19 Vaccination Timing and Risk Prioritization on Mortality Rates, United States (2021) (12)
- Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus (2020) (11)
- Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins (2022) (10)
- A high-throughput inhibition assay to study MERS-CoV antibody interactions using image cytometry (2018) (10)
- Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F2 Subunit Are Critical for Its Fusion Activity (2018) (10)
- The impacts of COVID-19 vaccine timing, number of doses, and risk prioritization on mortality in the US (2021) (10)
- Safety and immunogenicity of an egg-based inactivated Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomized, placebo-controlled, phase 1/2 trial in Vietnam (2022) (9)
- Prefusion coronavirus spike proteins and their use (2017) (8)
- Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. (2021) (8)
- Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape (2021) (8)
- Safety and Immunogenicity of an Inactivated Recombinant Newcastle Disease Virus Vaccine Expressing SARS-CoV-2 Spike: Interim Results of a Randomised, Placebo-Controlled, Phase 1/2 Trial (2021) (8)
- Iterative screen optimization maximizes the efficiency of macromolecular crystallization (2019) (8)
- Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies (2021) (7)
- Discovery of 3 ({5 Chloro-1 [3 (methylsulfonyl)propyl]-1H indol-2 yl}methyl)-1 (2,2,2 trifluoroethyl)-1,3 dihydro-2H imidazo[4,5-c]pyridin-2 one (JNJ-53718678), a potent and orally bioavailable fusion inhibitor of respiratory syncytial virus. (2020) (7)
- Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes (2021) (7)
- Trimeric SARS-CoV-2 Spike proteins produced from CHO-cells in bioreactors are high quality antigens (2020) (7)
- Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions (2020) (7)
- The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes (2022) (7)
- Chimeric Pneumoviridae fusion proteins as immunogens to induce cross‐neutralizing antibody responses (2017) (7)
- Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality (2021) (6)
- Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies (2022) (6)
- Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition (2022) (6)
- Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection (2020) (6)
- Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up (2020) (6)
- A Vulnerable, Membrane-Proximal Site in Human Respiratory Syncytial Virus F Revealed by a Prefusion-Specific Single-Domain Antibody (2021) (5)
- Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice (2022) (5)
- Protein engineering responses to the COVID-19 pandemic (2022) (4)
- Prefusion F–Based Polyanhydride Nanovaccine Induces Both Humoral and Cell-Mediated Immunity Resulting in Long-Lasting Protection against Respiratory Syncytial Virus (2021) (4)
- A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants (2021) (4)
- Principles and practical applications of structure-based vaccine design (2022) (4)
- Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin (2022) (3)
- Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking (2021) (3)
- Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses (2010) (3)
- CryoEM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition (2021) (3)
- Analysis of Viral Spike Protein N-Glycosylation Using Ultraviolet Photodissociation Mass Spectrometry. (2022) (3)
- Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine (2022) (3)
- Structural basis for HCMV Pentamer recognition by antibodies and neuropilin 2 (2021) (3)
- Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus (2022) (2)
- Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis (2022) (2)
- HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization (2019) (2)
- Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein (2017) (2)
- Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus (2022) (2)
- Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike (2018) (1)
- Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice (2022) (1)
- Crystal Structure of Inhibitor JNJ-36689282 in Complex with Prefusion RSV F Glycoprotein (2020) (1)
- Robust immune response and protection generated by a polyanhydride-based nanoparticle vaccine utilizing the RSV prefusion F protein and/or M protein (2019) (1)
- Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses (2022) (1)
- Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition (2021) (1)
- Architecture and antigenicity of the nipah virus attachment glycoprotein (2022) (1)
- IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern (2022) (1)
- Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein. (2022) (1)
- Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses (2019) (1)
- Structure of the RSV F protein in the post-fusion conformation (2011) (1)
- Polyanhydride-based RSV prefusion F nanoparticle vaccine establishes lasting protection mediated by humoral and cellular immune responses (2020) (1)
- Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor (2017) (1)
- Crystal Structure of Prefusion-stabilized RSV F variant PR-DM (2015) (1)
- Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 (2011) (1)
- Crystal Structure of Inhibitor JNJ-40012665 in Complex with Prefusion RSV F Glycoprotein (2020) (0)
- X-Ray Diffraction data from Human metapneumovirus fusion glycoprotein stabilized in the prefusion state, source of 5WB0 structure (2018) (0)
- Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups (2022) (0)
- Crystal Structure of RSV-Neutralizing Human Antibody D25 (2013) (0)
- Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis (2018) (0)
- Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 (2018) (0)
- Structure of the RSV Polymerase Complex Reveals a Tentacular Arrangement of the Viral Phosphoprotein (2020) (0)
- Crystal Structure of MERS-CoV neutralizing antibody G4 Fab (2017) (0)
- D108 Synthetic HIV-1 Glycopeptides Enable Characterization of Fine Epitopes of Broadly Neutralizing Antibody PG9 (2013) (0)
- A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice (2022) (0)
- Stabilized SARS-CoV-2 spike S2 immunogens designed using insights from enhanced sampling molecular dynamics simulations (2023) (0)
- Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2 (2005) (0)
- X-Ray Diffraction data from RSV F in complex with 5C4 Fab, source of 5W23 structure (2017) (0)
- Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope (2010) (0)
- Cryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the Tetrameric Phosphoprotein (P) (2019) (0)
- Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 Env gp120 (2014) (0)
- Local methods to improve cryo-electron microcopy maps (2021) (0)
- SARS Spike Glycoprotein, Stabilized variant, two S1 CTDs in the upwards conformation (2018) (0)
- Prefusion structure of PEDV spike (2019) (0)
- Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2 (2021) (0)
- Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin (2023) (0)
- Crystal structure of RV144-elicited antibody CH59 in complex with V2 peptide (2013) (0)
- X-Ray Diffraction data from Motavizumab and AM14 in Complex with Prefusion RSV F, source of 4ZYP structure (2015) (0)
- X-Ray Diffraction data from RSV F B9320 Bound to MEDI8897, source of 5UDD structure (2017) (0)
- Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1-TriC at pH 9.5 (2013) (0)
- Crystal Structure of Stabilized GP from Makona Variant of Ebola Virus (2020) (0)
- Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses (2023) (0)
- Prefusion RSV F monomer bound by neutralizing antibody CR9501 (2019) (0)
- Crystal Structure of Inhibitor BMS-433771 in Complex with Prefusion RSV F Glycoprotein (2015) (0)
- The mechanism of T. cruzi FPPS involves a substrate induced conformational change (2005) (0)
- Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein (2015) (0)
- Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with disordered HBGA type Lea (2011) (0)
- X-Ray Diffraction data from Single-Domain Antibody F-VHH-4, source of 5TP3 structure (2017) (0)
- Crystal Structure of MERS-CoV neutralizing antibody G2 Fab (2019) (0)
- Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO (2008) (0)
- Crystal Structure of RSV F B9320 DS-Cav1 (2017) (0)
- Crystal Structure of RSV F B9320 Bound to MEDI8897 (2017) (0)
- Respiratory syncytial virus entry and how to block it (2019) (0)
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness (2020) (0)
- Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with HBGA type H2 (triglycan) (2011) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F488I STABILIZED IN THE PREFUSION STATE (2019) (0)
- Crystal Structure of RSV F in complex with 5C4 Fab (2017) (0)
- A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus (2022) (0)
- RSV G central conserved region bound to Fab CB017.5 (2018) (0)
- Using X-ray crystallography to fight back against pneumoviruses (2018) (0)
- Crystal Structure of the First and Second FNIII Domains of Ihog (2006) (0)
- Automated method for iterative optimization of macromolecular crystallization screens (2017) (0)
- RSV prefusion F bound to RSD5 Fab (2019) (0)
- SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, C3 symmetry (2018) (0)
- Crystal structure of the anti-hiv-1 antibody 2.2c (2014) (0)
- Structure-based Vaccine Design: Lessons from RSV F (2016) (0)
- Crystal structure of human metapneumovirus fusion glycoprotein stabilized in the prefusion state (2017) (0)
- Crystal structure of RV144-elicited antibody CH58 (2013) (0)
- X-Ray Diffraction data from Human respiratory syncytial virus fusion protein in complex with fusion inhibitor JNJ-53718678, source of 5KWW structure (2017) (0)
- Crystal structure of a motavizumab epitope-scaffold bound to motavizumab Fab (2011) (0)
- Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab (2019) (0)
- Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide (2013) (0)
- Prefusion RSV F Bound to RV521 (2021) (0)
- X-Ray Diffraction data from MERS-CoV S2-specific Fab G4, source of 5VZR structure (2017) (0)
- RSV-neutralizing human antibody AM22 (2019) (0)
- Progress in vaccine development for infectious diseases-a Keystone Symposia report. (2023) (0)
- Structural basis for ultrapotent neutralization of human metapneumovirus (2022) (0)
- Structure of RSV F in Complex with VHH Cl184 (2021) (0)
- Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with Fucose (2011) (0)
- Crystal Structure of Hedgehog Bound to the FNIII Domains of Ihog (2006) (0)
- RSV prefusion F in complex with AM22 Fab (2019) (0)
- SARS-CoV-2 S-NTD + Fab CM25 (2021) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT K394R-S398L STABILIZED IN THE PREFUSION STATE (2019) (0)
- Hedgehog proteins require different co-factors to bind vertebrate and invertebrate Ihog homologs (2009) (0)
- Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with HBGA type H2 (diglycan) (2011) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT E487D STABILIZED IN THE PREFUSION STATE (2019) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT T400A STABILIZED IN THE PREFUSION STATE (2019) (0)
- Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope (2010) (0)
- CRYSTAL STRUCTURE OF FUSION INHIBITOR JNJ-2408068 IN COMPLEX WITH HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE (2019) (0)
- Crystal Structure of Protective Ebola Virus Antibody 100 (2016) (0)
- Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B. (2019) (0)
- X-Ray Diffraction data from RSV F B9320 DS-Cav1, source of 5UDE structure (2017) (0)
- Crystal structure of anti-HIV llama VHH antibody A12 (2012) (0)
- Crystal Structure of Infant Antibody ADI-19425 (2018) (0)
- The SARS-CoV-2 spike protein reversibly samples an open-trimer conformation exposing novel epitopes (2022) (0)
- X-Ray Diffraction data from RSV G peptide bound to Fab CB002.5, source of 6BLI structure (2018) (0)
- SARS Spike Glycoprotein, Stabilized variant, C3 symmetry (2018) (0)
- Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 (2011) (0)
- Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein (2022) (0)
- Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape (2021) (0)
- Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21 (2021) (0)
- SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, two S1 CTDs in an upwards conformation (2018) (0)
- X-Ray Diffraction data from Crystal Structure of RSV F A2 Bound to MEDI8897, source of 5UDC structure (2017) (0)
- Vulnerabilities in coronavirus glycan shields despite extensive glycosylation (2020) (0)
- X-Ray Diffraction data from 5C4 Fab, source of 5W24 structure (2017) (0)
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness Preview (2020) (0)
- Crystal Structure of Inhibitor JNJ-36811054 in Complex with Prefusion RSV F Glycoprotein (2020) (0)
- Crystal Structure of PG9 Fab (2011) (0)
- Crystal structure of the HCMV pentamer-specific antibody 2-25 (2021) (0)
- X-Ray Diffraction data from Protective Ebola Virus Antibody 100, source of 5FHB structure (2016) (0)
- Robust efficacy and long-lasting humoral immunity induced by a respiratory syncytial virus prefusion F-based nanoparticle vaccine in genetically diverse animal models (2022) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE (2019) (0)
- Molecular Dissection Of Human Antibody Responses Following Prefusion-Stabilized RSV F Vaccination (2020) (0)
- X-Ray Diffraction data from VHH-L66 in Complex with Prefusion RSV F, source of 5TOK structure (2017) (0)
- Activate ERK1 and ERK2 Interacts with DC-SIGN and L-SIGN To Respiratory Syncytial Virus Glycoprotein G (2012) (0)
- X-Ray Diffraction data from human metapneumovirus fusion protein in postfusion conformation, source of 5L1X structure (2016) (0)
- Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66 (2017) (0)
- Crystal structure of Fab ADI-14442 (2021) (0)
- X-Ray Diffraction data from RSV-Neutralizing Human Antibody AM14, source of 4ZYK structure (2015) (0)
- Crystal Structure of 5C4 Fab (2017) (0)
- Crystal Structure of Protective Ebola Virus Antibody 114 (2016) (0)
- Transient opening of trimeric prefusion RSV F proteins (2019) (0)
- Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein (2018) (0)
- Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs (2019) (0)
- Trypanosoma cruzi farnesyl diphosphate synthase (2005) (0)
- X-Ray Diffraction data from Prefusion RSV F Glycoprotein In Complex with Inhibitor JNJ-49153390, source of 5EA4 structure (2016) (0)
- X-Ray Diffraction data from Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP), source of 5FHC structure (2016) (0)
- Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25 (2013) (0)
- A Model Interaction for Structural Biology and Health Research: Implications of the Antibody D25 bound to the RSV Pre‐Fusion Glycoprotein (LB100) (2014) (0)
- Evidence for breathing of a class I fusion protein at the cell surface (2018) (0)
- Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4 (2017) (0)
- Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120 (2012) (0)
- Selected talk 2 MCMV exploits the spleen as a transfer hub for systemic dissemination upon oronasal inoculation (2015) (0)
- HIV-1 Infection Response Implicated in Reduced Risk for Antibody-Dependent Cellular Cytotoxicity Structural Definition of an (2014) (0)
- Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14 (2015) (0)
- RSV G peptide bound to Fab CB002.5 (2018) (0)
- X-Ray Diffraction data from Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y, source of 5EA8 structure (2016) (0)
- Crystal structure of the SARS-CoV-1 RBD bound by the cross-reactive single-domain antibody SARS VHH-72 (2020) (0)
- McLellan Respiratory Syncytial Virus Structure-Based Design of a Fusion Glycoprotein Vaccine for (2014) (0)
- The 3.1 Å structure of the porcine epidemic diarrhea virus spike protein in the (2019) (0)
- Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y (2015) (0)
- Structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with risedronate, dmapp and mg+2 (2005) (0)
- Crystal Structure of the First FNIII Domain of Ihog (2006) (0)
- X-Ray Diffraction data from MERS-CoV S1 NTD, source of 5VYH structure (2017) (0)
- Structure of RSV F-directed VHH Cl184 (2021) (0)
- SARS-CoV-2 HexaPro S One RBD up (2020) (0)
- Structure of the Human Metapneumovirus Fusion Protein in the Postfusion Conformation (2016) (0)
- Crystal Structure of Motavizumab Fab Bound to Peptide Epitope (2010) (0)
- D-107 Structure and Stabilization of Coronavirus Spike Proteins in the Prefusion Conformation (2017) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT S398L STABILIZED IN THE PREFUSION STATE (2019) (0)
- Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP) (2016) (0)
- Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein (2017) (0)
- Crystal structure of potent neutralizing antibody CDC2-C2 in complex with MERS-CoV S1 RBD (2018) (0)
- X-Ray Diffraction data from Prefusion-stabilized RSV F Ectodomain (PR-DM), source of 5C69 structure (2015) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT L141W STABILIZED IN THE PREFUSION STATE (2019) (0)
- Long-Lasting Protection Induced by a Polyanhydride Nanovaccine against Respiratory Syncytial Virus in an Outbred Mouse Model (2022) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F140I STABILIZED IN THE PREFUSION STATE (2019) (0)
- SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles (2018) (0)
- SARS-CoV-2 S stem helix peptide bound to Fab22 (2021) (0)
- Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern (2022) (0)
- Immunogenicity of a DNA vaccine candidate for COVID-19 (2020) (0)
- Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis (2018) (0)
- Structural Basis of Neutralization by Human Antibodies Targeting Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Gc (2020) (0)
- SARS-CoV 2 Spike Protein bound to LY-CoV555 (2021) (0)
- Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with HBGA type Ley (2011) (0)
- CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT D486N STABILIZED IN THE PREFUSION STATE (2019) (0)
- Crystal structure of the HCMV pentamer-specific antibody 1-103 (2021) (0)
- Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B (2021) (0)
- 3-25 Fab germline-reversion variant bound to an HCMV gB-derived peptide (2020) (0)
- Crystal structure of the HCMV pentamer-specific Fab 2-18 (2021) (0)
- Crystal Structure of MERS-CoV S1 N-terminal Domain (2017) (0)
- Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 (2020) (0)
- SARS Spike Glycoprotein, Stabilized variant, single upwards S1 CTD conformation (2018) (0)
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