Jason W. Chin

Q: What Schools Are Affiliated With Jason W. Chin

Jason W. Chin is affiliated with the following schools: University of California, Berkeley, Yale University, Stanford University, University of Cambridge

Jason W. Chin's AcademicInfluence.com Rankings

Jason W. Chin

Biology

#11988

World Rank

#15433

Historical Rank

Molecular Biology

#1900

World Rank

#1931

Historical Rank

biology Degrees

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Biology

Jason W. Chin's Degrees

PhD Molecular Biology University of California, Berkeley
Bachelors Biochemistry Stanford University

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Jason W. Chin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Regulation of Cellular Metabolism by Protein Lysine Acetylation (2010) (1646)
Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. (2014) (721)
An Expanded Eukaryotic Genetic Code (2003) (696)
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. (2002) (622)
Addition of a photocrosslinking amino acid to the genetic code of Escherichia coli (2002) (602)
Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome (2010) (530)
Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. (2008) (499)
A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation (2009) (468)
Expanding and reprogramming the genetic code (2017) (443)
Bioorthogonal reactions for labeling proteins. (2014) (426)
Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions (2012) (411)
Expanding and reprogramming the genetic code of cells and animals. (2014) (394)
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. (2012) (382)
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. (2003) (334)
Designer proteins: applications of genetic code expansion in cell biology (2012) (291)
Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. (2009) (280)
A genetically encoded fluorescent amino acid. (2006) (277)
A network of orthogonal ribosome·mRNA pairs (2005) (274)
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion (2007) (273)
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. (2010) (267)
Total synthesis of Escherichia coli with a recoded genome (2019) (266)
Substrate recognition by the AAA+ chaperone ClpB (2004) (229)
CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication (2012) (223)
Genetically encoded photocontrol of protein localization in mammalian cells. (2010) (223)
Expanding the Genetic Code of an Animal (2011) (221)
DAXX envelops a histone H3.3–H4 dimer for H3.3-specific recognition (2012) (219)
Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly (2014) (212)
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET (2014) (211)
Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair (2010) (185)
Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1 (2014) (181)
Expanding the genetic code of Drosophila melanogaster. (2012) (175)
Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog. (2015) (163)
Traceless and Site-Specific Ubiquitination of Recombinant Proteins (2011) (152)
Photo-cross-linking interacting proteins with a genetically encoded benzophenone (2005) (145)
Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. (2014) (143)
Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells (2011) (143)
Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones. (2009) (142)
Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal (2014) (136)
In Vivo Photocrosslinking with Unnatural Amino Acid Mutagenesis (2002) (133)
Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins (2015) (131)
Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. (2011) (131)
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains (2011) (128)
Synthesis of orthogonal transcription-translation networks (2009) (124)
Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine. (2012) (121)
An Ankyrin-repeat ubiquitin binding domain determines TRABID’s specificity for atypical ubiquitin chains (2011) (119)
Defining synonymous codon compression schemes by genome recoding (2016) (115)
Genetic Encoding of Photocaged Cysteine Allows Photoactivation of TEV Protease in Live Mammalian Cells (2014) (111)
Genetically Encoded Optochemical Probes for Simultaneous Fluorescence Reporting and Light Activation of Protein Function with Two-Photon Excitation (2014) (110)
Genetic code expansion in stable cell lines enables encoded chromatin modification (2016) (110)
Selective, rapid and optically switchable regulation of protein function in live mammalian cells. (2015) (109)
Genetically encoding protein oxidative damage. (2008) (103)
A dual role of H4K16 acetylation in the establishment of yeast silent chromatin (2011) (103)
Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization (2010) (102)
Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins (2014) (102)
Toward an orthogonal central dogma. (2018) (97)
Design and Evolution of a Miniature Bcl-2 Binding Protein. (2001) (97)
Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing (2017) (94)
Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs (2018) (92)
Progress toward an expanded eukaryotic genetic code. (2003) (91)
Genetic code expansion in the mouse brain. (2016) (91)
Cellular logic with orthogonal ribosomes. (2005) (85)
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration (2011) (85)
Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones. (2010) (82)
Reprogramming the genetic code (2012) (82)
De novo generation of mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. (2010) (81)
Genetically encoding an aliphatic diazirine for protein photocrosslinking (2011) (78)
Concerted evolution of structure and function in a miniature protein. (2001) (77)
Modular approaches to expanding the functions of living matter (2006) (76)
Genetically encoded light-activated transcription for spatiotemporal control of gene expression and gene silencing in mammalian cells. (2013) (76)
Reprogramming the genetic code: from triplet to quadruplet codes. (2012) (75)
Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition† †Electronic supplementary information (ESI) available: Full experimental details, 1H/13C NMR spectral data, protein synthesis and purification. See DOI: 10.1039/c3sc53332h (2014) (67)
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms (2020) (62)
Labeling and identifying cell-specific proteomes in the mouse brain (2017) (62)
Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids (2020) (62)
Controlling orthogonal ribosome subunit interactions enables evolution of new function (2018) (62)
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid (2018) (59)
Efficient and Rapid C. elegans Transgenesis by Bombardment and Hygromycin B Selection (2013) (58)
Reprogramming the genetic code (2020) (57)
Rapid and Efficient Generation of Stable Antibody–Drug Conjugates via an Encoded Cyclopropene and an Inverse‐Electron‐Demand Diels–Alder Reaction (2018) (56)
EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling (2015) (52)
Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization (2015) (51)
Sense codon reassignment enables viral resistance and encoded polymer synthesis (2021) (50)
Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity (2016) (49)
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 (2018) (46)
Ribosome Subunit Stapling for Orthogonal Translation in E. coli (2015) (43)
Ribosome Subunit Stapling for Orthogonal Translation in E. coli (2015) (43)
Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs (2020) (43)
A view to a kill: ligands for Bcl-2 family proteins. (2002) (42)
Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix (2018) (42)
Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation* (2015) (41)
Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells (2017) (40)
Genetically Encoded Protein Phosphorylation in Mammalian Cells (2018) (37)
Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers (2014) (36)
Programming and engineering biological networks. (2006) (35)
An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells (2018) (34)
Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne (2015) (34)
Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly (2019) (34)
Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis (2017) (34)
Functional epitopes at the ribosome subunit interface (2006) (33)
Tagging and Enriching Proteins Enables Cell-Specific Proteomics (2016) (32)
Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes (2016) (32)
Genetically encoded optical activation of DNA recombination in human cells† †Electronic supplementary information (ESI) available: Experimental protocols. See DOI: 10.1039/c6cc03934k Click here for additional data file. (2016) (32)
Efficient Phage Display with Multiple Distinct Non‐Canonical Amino Acids Using Orthogonal Ribosome‐Mediated Genetic Code Expansion (2019) (31)
Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display. (2001) (30)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites (2021) (28)
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation (2018) (27)
Detecting RNA base methylations in single cells by in situ hybridization (2017) (27)
Engineering Escherichia coli heat-resistance by synthetic gene amplification. (2008) (27)
Reprogramming the genetic code (2011) (27)
Evolved orthogonal ribosome purification for in vitro characterization (2010) (26)
Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice (2018) (25)
Genetic code expansion and bioorthogonal labelling enables cell specific proteomics in an animal. (2014) (24)
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design (2021) (22)
Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ob01707c (2017) (21)
Reprogramming the amino-acid substrate specificity of orthogonal aminoacyl-tRNA synthetases to expand the genetic code of eukaryotic cells (2007) (21)
Genetic encoding of unnatural amino acids for labeling proteins. (2015) (18)
Engineered Diubiquitin Synthesis Reveals K29-Isopeptide Specificity of an Otu Deubiquitinase (2010) (16)
Reprogramming the Genetic Code: From Triplet to Quadruplet Codes (2012) (16)
Synthesizing cellular networks from evolved ribosome-mRNA pairs. (2006) (13)
Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins. (2014) (12)
Gene regulation: Protein escorts to the transcription ball (1999) (12)
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans (2022) (12)
High-efficacy subcellular micropatterning of proteins using fibrinogen anchors (2021) (11)
Selective CRAF Inhibition Elicits Transactivation. (2021) (11)
Towards a better understanding of the Coffea Arabica genome structure. (2015) (11)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons (2022) (10)
Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional (2017) (10)
Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS (2021) (8)
RBBP6 activates the pre-mRNA 3’-end processing machinery in humans (2021) (8)
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release (2018) (8)
An anchored chromosome‐scale genome assembly of spinach improves annotation and reveals extensive gene rearrangements in euasterids (2021) (8)
Mechanism-based traps enable protease and hydrolase substrate discovery (2022) (8)
Fluorescent imaging: Shining a light into live cells. (2013) (8)
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET (2017) (7)
Constitutively Activating Mutations At the FLT3 Activation Loop Residue D835 Are Associated with Clinical Resistance to AC220 (2012) (7)
Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio-Functionalization of PET (2022) (6)
Validation of FLT3-ITD As a Therapeutic Target in Human Acute Myeloid Leukemia (2011) (5)
The bacterial actin-like cell division protein FtsA forms curved antiparallel double filaments upon binding of FtsN (2021) (5)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites. (2021) (5)
Pyrophosphorylation via selective phosphoprotein derivatization† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01233d (2018) (4)
Initial de novo Assemblies of the D. melanogaster genome using long-read PacBio sequencing (2014) (4)
Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase (2021) (4)
Refactored genetic codes enable bidirectional genetic isolation (2022) (4)
Eukaryotic gene regulation (2000) (4)
Approaches taken, progress made, and enhanced utility of long read-based goat, swine, cattle and sheep reference genomes (2016) (4)
Single Molecule Real Time (SMRT™) Sequencing Sensitively Detects Polyclonal and Compound BCR-ABL in Patients Who Relapse on Kinase Inhibitor Therapy, (2011) (3)
Expanding nucleic acid function in vitro and in vivo. (2006) (3)
137-P: SINGLE MOLECULE REAL-TIME SEQUENCING OF FULL LENGTH HLA CLASS I GENES – THE PROMISE AND CURRENT REALITY (2012) (3)
SMRT® Sequencing Solutions for Large Genomes and Transcriptomes (2014) (3)
Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling (2017) (3)
Optically splitting symmetric neuron pairs in C. elegans (2020) (3)
Orthogonal gene expression in Escherichia coli. (2011) (3)
Highly Accurate SNP and Indel Calling on PacBio CCS with DeepVariant (2019) (2)
Bacterial divisome protein FtsA forms curved antiparallel double filaments upon binding FtsN (2022) (2)
Precise optical control of gene expression in C. elegans using genetic code expansion and Cre recombinase (2020) (1)
Protein Expression by Expansion of the Genetic Code (2006) (1)
Pyrophosphorylation via selective phosphoprotein derivatization (2018) (1)
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles (2022) (1)
Solvay Public Lectures New Chemistry and New Opportunities from the Expanding Protein Universe (2013) (1)
Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching (2022) (1)
Regulation of Nucleosome Conformational Dynamics by Post-Translational Histone Modifications Studied with Single-Pair FRET (2010) (1)
Parallel positive selections, deep sequencing and analysis for reprogramming aminoacyl-tRNA synthetase specificity (2017) (1)
Detecting RNA base methylations in single cells by in situ hybridization (2018) (1)
Current and future prospects in biopolymer chemistry (2007) (1)
Acetylation Regulation of Cellular Metabolism by Protein Lysine (2010) (1)
Correction to “Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins” (2018) (1)
Fibrinogen anchors enable efficient multiplexed patterning of active proteins and subcellular control of membrane-receptor distribution (2020) (0)
E. coli 70S d2d8 stapled ribosome (2018) (0)
Mitotic phosphorylation of Hsp72 uncouples ATP binding from substrate release and clusters amplified centrosomes in cancer cells. (2017) (0)
De novo assembly of the Drosophila Melanogaster fruit fly genome by long-read sequencing (2014) (0)
Controlling orthogonal ribosome subunit interactions enables evolution of new function (2018) (0)
Methods and compositions for the production of orthogonal tRNA pairs of aminoacyl-tRNA synthetase (2002) (0)
Live and let die : Bcl-2 family proteins regulate the intrinsic apoptotic pathway (0)
A better Drosophila Melanogaster genome by long-read sequencing (2014) (0)
Cell-of-origin–specific proteomics of extracellular vesicles (2023) (0)
tion via alkyne hydrosilylation using a substoichiometric amount of ruthenium ( II ) catalyst † ‡ (2017) (0)
Research highlights (2005) (0)
Dihaploid Coffea arabica Genome Sequencing and Assembly (2015) (0)
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms (2020) (0)
Astrocytic control of extra-cellular GABA drives circadian time-keeping in the suprachiasmatic nucleus (2023) (0)
The Genetic Code is Read by an Idiosyncratic and Highly-Connected Decoding Network (2019) (0)
Total synthesis of Escherichia coli with a recoded genome (2019) (0)
Author response: EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling (2015) (0)
Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs (2020) (0)
Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 (2016) (0)
Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a dodecadepsipeptide, space group H3 (2018) (0)
Compositions and methods in conjunction with orthogonal ribosome mRNA pairs (2006) (0)
Author response: Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 (2018) (0)
One-sentence summary: Phosphorylation uncouples the functions of the chaperone Hsp72 during mitosis. Editor’s summary: Modified Hsp72 structure-function in mitosis (2018) (0)
Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist (2018) (0)
Towards an Orthogonal Central Dogma (Preprint) (2018) (0)
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid (2018) (0)
Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 (2019) (0)
acetyl-CypA:cyclosporine complex (2010) (0)
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation (2018) (0)
HIV-1 capsid binds host cofactors to mediate nuclear import (2014) (0)
Free acetyl-CypA orthorhombic form (2010) (0)
Dihaploid Coffea arabica genome sequencing and assembly [W180] (2015) (0)
DIX domain of human Dvl2 (2015) (0)
Free acetyl-CypA trigonal form (2010) (0)
Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd)LBD in Complex with DN003316 (2019) (0)
Author response: Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase (2021) (0)
Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 (2018) (0)
acetyl-CypA:HIV-1 N-term capsid domain complex (2010) (0)
Automated, Non-Hybrid De Novo Genome Assemblies and Epigenomes of Bacterial Pathogens (2013) (0)
Complex structure 4 of DAXX(E225A)/H3.3(sub5)/H4 (2012) (0)
String Graph Assembly for Diploid Genomes with Long Reads (2014) (0)
Effect of Histone Acetylation on Nucleosome Dynamics Revealed by spFRET Microscopy (2009) (0)
Abstract 850: Comprehensive genome and transcriptome structural analysis of a breast cancer cell line using single molecule sequencing (2016) (0)
Mechanism-based traps enable protease and hydrolase substrate discovery (2022) (0)
PROGRAMMING NEW CHEMISTRY INTO THE GENETIC CODE OF CELLS AND ANIMALS (2014) (0)
GENERATION OF MULTIPLE FULL LENGTH HLA CLASS I GENE SEQUENCES IN A SINGLE SEQUENCING REACTION USING SMRT DNA SEQUENCING TECHNOLOGY (2014) (0)
Ser20 phosphorylated ubiquitin (2016) (0)
Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a tetradepsipeptide (2018) (0)
tion via selective phosphoprotein derivatization † (2018) (0)
Towards Finished Genome Assemblies using SMRT ® Sequencing (2013) (0)
Complex structure 5 of DAXX(E225A)/H3.3(sub5,G90A)/H4 (2012) (0)
Un-zipping Diploid Genome – Revealing the Heterozygous Variants From Comprehensive Haplotig Assembly (2016) (0)
Fibrinogen anchors for micropatterning of active proteins and subcellular receptor relocalisation (2020) (0)
Aurora-A / TACC 3 / Clathrin complexation (2018) (0)
Extension du code genetique eucaryote (2004) (0)
Complex structure 6 of DAXX/H3.3(sub7)/H4 (2012) (0)

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Other Resources About Jason W. Chin

www2.mrc-lmb.cam.ac.uk

What Schools Are Affiliated With Jason W. Chin?

Jason W. Chin is affiliated with the following schools:

Jason W. Chin's Academic­Influence.com Rankings