Jason W. Chin
#155,730
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Molecular biologist
Jason W. Chin's AcademicInfluence.com Rankings
Jason W. Chinbiology Degrees
Biology
#11988
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Molecular Biology
#1900
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#1931
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Biology
Jason W. Chin's Degrees
- PhD Molecular Biology University of California, Berkeley
- Bachelors Biochemistry Stanford University
Why Is Jason W. Chin Influential?
(Suggest an Edit or Addition)Jason W. Chin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Regulation of Cellular Metabolism by Protein Lysine Acetylation (2010) (1646)
- Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. (2014) (721)
- An Expanded Eukaryotic Genetic Code (2003) (696)
- Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. (2002) (622)
- Addition of a photocrosslinking amino acid to the genetic code of Escherichia coli (2002) (602)
- Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome (2010) (530)
- Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. (2008) (499)
- A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation (2009) (468)
- Expanding and reprogramming the genetic code (2017) (443)
- Bioorthogonal reactions for labeling proteins. (2014) (426)
- Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions (2012) (411)
- Expanding and reprogramming the genetic code of cells and animals. (2014) (394)
- Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. (2012) (382)
- Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. (2003) (334)
- Designer proteins: applications of genetic code expansion in cell biology (2012) (291)
- Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. (2009) (280)
- A genetically encoded fluorescent amino acid. (2006) (277)
- A network of orthogonal ribosome·mRNA pairs (2005) (274)
- Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion (2007) (273)
- Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. (2010) (267)
- Total synthesis of Escherichia coli with a recoded genome (2019) (266)
- Substrate recognition by the AAA+ chaperone ClpB (2004) (229)
- CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication (2012) (223)
- Genetically encoded photocontrol of protein localization in mammalian cells. (2010) (223)
- Expanding the Genetic Code of an Animal (2011) (221)
- DAXX envelops a histone H3.3–H4 dimer for H3.3-specific recognition (2012) (219)
- Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly (2014) (212)
- Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET (2014) (211)
- Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair (2010) (185)
- Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1 (2014) (181)
- Expanding the genetic code of Drosophila melanogaster. (2012) (175)
- Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog. (2015) (163)
- Traceless and Site-Specific Ubiquitination of Recombinant Proteins (2011) (152)
- Photo-cross-linking interacting proteins with a genetically encoded benzophenone (2005) (145)
- Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. (2014) (143)
- Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells (2011) (143)
- Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones. (2009) (142)
- Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal (2014) (136)
- In Vivo Photocrosslinking with Unnatural Amino Acid Mutagenesis (2002) (133)
- Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins (2015) (131)
- Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. (2011) (131)
- Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains (2011) (128)
- Synthesis of orthogonal transcription-translation networks (2009) (124)
- Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine. (2012) (121)
- An Ankyrin-repeat ubiquitin binding domain determines TRABID’s specificity for atypical ubiquitin chains (2011) (119)
- Defining synonymous codon compression schemes by genome recoding (2016) (115)
- Genetic Encoding of Photocaged Cysteine Allows Photoactivation of TEV Protease in Live Mammalian Cells (2014) (111)
- Genetically Encoded Optochemical Probes for Simultaneous Fluorescence Reporting and Light Activation of Protein Function with Two-Photon Excitation (2014) (110)
- Genetic code expansion in stable cell lines enables encoded chromatin modification (2016) (110)
- Selective, rapid and optically switchable regulation of protein function in live mammalian cells. (2015) (109)
- Genetically encoding protein oxidative damage. (2008) (103)
- A dual role of H4K16 acetylation in the establishment of yeast silent chromatin (2011) (103)
- Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization (2010) (102)
- Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins (2014) (102)
- Toward an orthogonal central dogma. (2018) (97)
- Design and Evolution of a Miniature Bcl-2 Binding Protein. (2001) (97)
- Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing (2017) (94)
- Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs (2018) (92)
- Progress toward an expanded eukaryotic genetic code. (2003) (91)
- Genetic code expansion in the mouse brain. (2016) (91)
- Cellular logic with orthogonal ribosomes. (2005) (85)
- Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration (2011) (85)
- Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones. (2010) (82)
- Reprogramming the genetic code (2012) (82)
- De novo generation of mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. (2010) (81)
- Genetically encoding an aliphatic diazirine for protein photocrosslinking (2011) (78)
- Concerted evolution of structure and function in a miniature protein. (2001) (77)
- Modular approaches to expanding the functions of living matter (2006) (76)
- Genetically encoded light-activated transcription for spatiotemporal control of gene expression and gene silencing in mammalian cells. (2013) (76)
- Reprogramming the genetic code: from triplet to quadruplet codes. (2012) (75)
- Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition† †Electronic supplementary information (ESI) available: Full experimental details, 1H/13C NMR spectral data, protein synthesis and purification. See DOI: 10.1039/c3sc53332h (2014) (67)
- Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms (2020) (62)
- Labeling and identifying cell-specific proteomes in the mouse brain (2017) (62)
- Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids (2020) (62)
- Controlling orthogonal ribosome subunit interactions enables evolution of new function (2018) (62)
- Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid (2018) (59)
- Efficient and Rapid C. elegans Transgenesis by Bombardment and Hygromycin B Selection (2013) (58)
- Reprogramming the genetic code (2020) (57)
- Rapid and Efficient Generation of Stable Antibody–Drug Conjugates via an Encoded Cyclopropene and an Inverse‐Electron‐Demand Diels–Alder Reaction (2018) (56)
- EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling (2015) (52)
- Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization (2015) (51)
- Sense codon reassignment enables viral resistance and encoded polymer synthesis (2021) (50)
- Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity (2016) (49)
- Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 (2018) (46)
- Ribosome Subunit Stapling for Orthogonal Translation in E. coli (2015) (43)
- Ribosome Subunit Stapling for Orthogonal Translation in E. coli (2015) (43)
- Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs (2020) (43)
- A view to a kill: ligands for Bcl-2 family proteins. (2002) (42)
- Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix (2018) (42)
- Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation* (2015) (41)
- Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells (2017) (40)
- Genetically Encoded Protein Phosphorylation in Mammalian Cells (2018) (37)
- Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers (2014) (36)
- Programming and engineering biological networks. (2006) (35)
- An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells (2018) (34)
- Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne (2015) (34)
- Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly (2019) (34)
- Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis (2017) (34)
- Functional epitopes at the ribosome subunit interface (2006) (33)
- Tagging and Enriching Proteins Enables Cell-Specific Proteomics (2016) (32)
- Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes (2016) (32)
- Genetically encoded optical activation of DNA recombination in human cells† †Electronic supplementary information (ESI) available: Experimental protocols. See DOI: 10.1039/c6cc03934k Click here for additional data file. (2016) (32)
- Efficient Phage Display with Multiple Distinct Non‐Canonical Amino Acids Using Orthogonal Ribosome‐Mediated Genetic Code Expansion (2019) (31)
- Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display. (2001) (30)
- Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites (2021) (28)
- A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation (2018) (27)
- Detecting RNA base methylations in single cells by in situ hybridization (2017) (27)
- Engineering Escherichia coli heat-resistance by synthetic gene amplification. (2008) (27)
- Reprogramming the genetic code (2011) (27)
- Evolved orthogonal ribosome purification for in vitro characterization (2010) (26)
- Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice (2018) (25)
- Genetic code expansion and bioorthogonal labelling enables cell specific proteomics in an animal. (2014) (24)
- A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design (2021) (22)
- Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ob01707c (2017) (21)
- Reprogramming the amino-acid substrate specificity of orthogonal aminoacyl-tRNA synthetases to expand the genetic code of eukaryotic cells (2007) (21)
- Genetic encoding of unnatural amino acids for labeling proteins. (2015) (18)
- Engineered Diubiquitin Synthesis Reveals K29-Isopeptide Specificity of an Otu Deubiquitinase (2010) (16)
- Reprogramming the Genetic Code: From Triplet to Quadruplet Codes (2012) (16)
- Synthesizing cellular networks from evolved ribosome-mRNA pairs. (2006) (13)
- Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins. (2014) (12)
- Gene regulation: Protein escorts to the transcription ball (1999) (12)
- RBBP6 activates the pre-mRNA 3′ end processing machinery in humans (2022) (12)
- High-efficacy subcellular micropatterning of proteins using fibrinogen anchors (2021) (11)
- Selective CRAF Inhibition Elicits Transactivation. (2021) (11)
- Towards a better understanding of the Coffea Arabica genome structure. (2015) (11)
- Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons (2022) (10)
- Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional (2017) (10)
- Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS (2021) (8)
- RBBP6 activates the pre-mRNA 3’-end processing machinery in humans (2021) (8)
- Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release (2018) (8)
- An anchored chromosome‐scale genome assembly of spinach improves annotation and reveals extensive gene rearrangements in euasterids (2021) (8)
- Mechanism-based traps enable protease and hydrolase substrate discovery (2022) (8)
- Fluorescent imaging: Shining a light into live cells. (2013) (8)
- Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET (2017) (7)
- Constitutively Activating Mutations At the FLT3 Activation Loop Residue D835 Are Associated with Clinical Resistance to AC220 (2012) (7)
- Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio-Functionalization of PET (2022) (6)
- Validation of FLT3-ITD As a Therapeutic Target in Human Acute Myeloid Leukemia (2011) (5)
- The bacterial actin-like cell division protein FtsA forms curved antiparallel double filaments upon binding of FtsN (2021) (5)
- Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites. (2021) (5)
- Pyrophosphorylation via selective phosphoprotein derivatization† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01233d (2018) (4)
- Initial de novo Assemblies of the D. melanogaster genome using long-read PacBio sequencing (2014) (4)
- Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase (2021) (4)
- Refactored genetic codes enable bidirectional genetic isolation (2022) (4)
- Eukaryotic gene regulation (2000) (4)
- Approaches taken, progress made, and enhanced utility of long read-based goat, swine, cattle and sheep reference genomes (2016) (4)
- Single Molecule Real Time (SMRT™) Sequencing Sensitively Detects Polyclonal and Compound BCR-ABL in Patients Who Relapse on Kinase Inhibitor Therapy, (2011) (3)
- Expanding nucleic acid function in vitro and in vivo. (2006) (3)
- 137-P: SINGLE MOLECULE REAL-TIME SEQUENCING OF FULL LENGTH HLA CLASS I GENES – THE PROMISE AND CURRENT REALITY (2012) (3)
- SMRT® Sequencing Solutions for Large Genomes and Transcriptomes (2014) (3)
- Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling (2017) (3)
- Optically splitting symmetric neuron pairs in C. elegans (2020) (3)
- Orthogonal gene expression in Escherichia coli. (2011) (3)
- Highly Accurate SNP and Indel Calling on PacBio CCS with DeepVariant (2019) (2)
- Bacterial divisome protein FtsA forms curved antiparallel double filaments upon binding FtsN (2022) (2)
- Precise optical control of gene expression in C. elegans using genetic code expansion and Cre recombinase (2020) (1)
- Protein Expression by Expansion of the Genetic Code (2006) (1)
- Pyrophosphorylation via selective phosphoprotein derivatization (2018) (1)
- Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles (2022) (1)
- Solvay Public Lectures New Chemistry and New Opportunities from the Expanding Protein Universe (2013) (1)
- Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching (2022) (1)
- Regulation of Nucleosome Conformational Dynamics by Post-Translational Histone Modifications Studied with Single-Pair FRET (2010) (1)
- Parallel positive selections, deep sequencing and analysis for reprogramming aminoacyl-tRNA synthetase specificity (2017) (1)
- Detecting RNA base methylations in single cells by in situ hybridization (2018) (1)
- Current and future prospects in biopolymer chemistry (2007) (1)
- Acetylation Regulation of Cellular Metabolism by Protein Lysine (2010) (1)
- Correction to “Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins” (2018) (1)
- Fibrinogen anchors enable efficient multiplexed patterning of active proteins and subcellular control of membrane-receptor distribution (2020) (0)
- E. coli 70S d2d8 stapled ribosome (2018) (0)
- Mitotic phosphorylation of Hsp72 uncouples ATP binding from substrate release and clusters amplified centrosomes in cancer cells. (2017) (0)
- De novo assembly of the Drosophila Melanogaster fruit fly genome by long-read sequencing (2014) (0)
- Controlling orthogonal ribosome subunit interactions enables evolution of new function (2018) (0)
- Methods and compositions for the production of orthogonal tRNA pairs of aminoacyl-tRNA synthetase (2002) (0)
- Live and let die : Bcl-2 family proteins regulate the intrinsic apoptotic pathway (0)
- A better Drosophila Melanogaster genome by long-read sequencing (2014) (0)
- Cell-of-origin–specific proteomics of extracellular vesicles (2023) (0)
- tion via alkyne hydrosilylation using a substoichiometric amount of ruthenium ( II ) catalyst † ‡ (2017) (0)
- Research highlights (2005) (0)
- Dihaploid Coffea arabica Genome Sequencing and Assembly (2015) (0)
- Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms (2020) (0)
- Astrocytic control of extra-cellular GABA drives circadian time-keeping in the suprachiasmatic nucleus (2023) (0)
- The Genetic Code is Read by an Idiosyncratic and Highly-Connected Decoding Network (2019) (0)
- Total synthesis of Escherichia coli with a recoded genome (2019) (0)
- Author response: EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling (2015) (0)
- Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs (2020) (0)
- Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 (2016) (0)
- Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a dodecadepsipeptide, space group H3 (2018) (0)
- Compositions and methods in conjunction with orthogonal ribosome mRNA pairs (2006) (0)
- Author response: Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 (2018) (0)
- One-sentence summary: Phosphorylation uncouples the functions of the chaperone Hsp72 during mitosis. Editor’s summary: Modified Hsp72 structure-function in mitosis (2018) (0)
- Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist (2018) (0)
- Towards an Orthogonal Central Dogma (Preprint) (2018) (0)
- Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid (2018) (0)
- Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 (2019) (0)
- acetyl-CypA:cyclosporine complex (2010) (0)
- A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation (2018) (0)
- HIV-1 capsid binds host cofactors to mediate nuclear import (2014) (0)
- Free acetyl-CypA orthorhombic form (2010) (0)
- Dihaploid Coffea arabica genome sequencing and assembly [W180] (2015) (0)
- DIX domain of human Dvl2 (2015) (0)
- Free acetyl-CypA trigonal form (2010) (0)
- Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd)LBD in Complex with DN003316 (2019) (0)
- Author response: Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase (2021) (0)
- Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 (2018) (0)
- acetyl-CypA:HIV-1 N-term capsid domain complex (2010) (0)
- Automated, Non-Hybrid De Novo Genome Assemblies and Epigenomes of Bacterial Pathogens (2013) (0)
- Complex structure 4 of DAXX(E225A)/H3.3(sub5)/H4 (2012) (0)
- String Graph Assembly for Diploid Genomes with Long Reads (2014) (0)
- Effect of Histone Acetylation on Nucleosome Dynamics Revealed by spFRET Microscopy (2009) (0)
- Abstract 850: Comprehensive genome and transcriptome structural analysis of a breast cancer cell line using single molecule sequencing (2016) (0)
- Mechanism-based traps enable protease and hydrolase substrate discovery (2022) (0)
- PROGRAMMING NEW CHEMISTRY INTO THE GENETIC CODE OF CELLS AND ANIMALS (2014) (0)
- GENERATION OF MULTIPLE FULL LENGTH HLA CLASS I GENE SEQUENCES IN A SINGLE SEQUENCING REACTION USING SMRT DNA SEQUENCING TECHNOLOGY (2014) (0)
- Ser20 phosphorylated ubiquitin (2016) (0)
- Vlm2 thioesterase domain with genetically encoded 2,3-diaminopropionic acid bound with a tetradepsipeptide (2018) (0)
- tion via selective phosphoprotein derivatization † (2018) (0)
- Towards Finished Genome Assemblies using SMRT ® Sequencing (2013) (0)
- Complex structure 5 of DAXX(E225A)/H3.3(sub5,G90A)/H4 (2012) (0)
- Un-zipping Diploid Genome – Revealing the Heterozygous Variants From Comprehensive Haplotig Assembly (2016) (0)
- Fibrinogen anchors for micropatterning of active proteins and subcellular receptor relocalisation (2020) (0)
- Aurora-A / TACC 3 / Clathrin complexation (2018) (0)
- Extension du code genetique eucaryote (2004) (0)
- Complex structure 6 of DAXX/H3.3(sub7)/H4 (2012) (0)
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