Jason Locasale
#74,963
Most Influential Person Now
Researcher
Jason Locasale's AcademicInfluence.com Rankings
Jason Locasalebiology Degrees
Biology
#6166
World Rank
#8822
Historical Rank
Biochemistry
#1195
World Rank
#1314
Historical Rank
Download Badge
Mathematics Biology
Jason Locasale's Degrees
- Bachelors Biochemistry University of California, San Diego
Why Is Jason Locasale Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jason W. Locasale is an American scientist and university professor. His focus is on metabolism. Education Locasale graduated summa cum laude from Rutgers University with a dual degree in Chemistry and Physics. While completing his undergraduate degree, he received initial training in research in biochemistry and structural biology under Helen Berman. He earned a Ph.D. from the Massachusetts Institute of Technology. He went on to complete a postdoctoral fellowship at Harvard Medical School under Lewis C. Cantley.
Jason Locasale's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Warburg Effect: How Does it Benefit Cancer Cells? (2016) (2494)
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism (2012) (1527)
- Serine, glycine and one-carbon units: cancer metabolism in full circle (2013) (1154)
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses (2011) (983)
- Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis (2011) (942)
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses (2015) (930)
- Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells (2010) (543)
- Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation (2013) (517)
- Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. (2015) (505)
- A roadmap for interpreting (13)C metabolite labeling patterns from cells. (2015) (468)
- Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. (2015) (412)
- Glutamine Metabolism in Cancer: Understanding the Heterogeneity. (2017) (382)
- Metabolic flux and the regulation of mammalian cell growth. (2011) (365)
- Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism (2018) (350)
- Heterogeneity of tumor-induced gene expression changes in the human metabolic network (2013) (345)
- The impact of cellular metabolism on chromatin dynamics and epigenetics (2017) (317)
- Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis (2017) (316)
- T cell stemness and dysfunction in tumors are triggered by a common mechanism (2019) (284)
- Metabolic pathway alterations that support cell proliferation. (2011) (263)
- Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression (2016) (261)
- Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells (2018) (258)
- mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. (2016) (255)
- Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases (2010) (255)
- Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation (2016) (252)
- Cancer Cell Metabolism (2012) (250)
- Metabolic landscape of the tumor microenvironment at single cell resolution (2019) (237)
- Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies (2019) (234)
- mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. (2011) (230)
- One‐carbon metabolism and epigenetics: understanding the specificity (2016) (224)
- Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step (2014) (206)
- Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function (2016) (204)
- Metabolomics: A Primer. (2017) (203)
- Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis (2015) (201)
- Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (2011) (198)
- Designing a broad-spectrum integrative approach for cancer prevention and treatment. (2015) (194)
- Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals (2018) (192)
- Methionine metabolism in health and cancer: a nexus of diet and precision medicine (2019) (185)
- AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. (2016) (181)
- Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers. (2016) (173)
- Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism (2019) (170)
- Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology (2014) (165)
- The metabolic co-regulator PGC1α suppresses prostate cancer metastasis (2016) (162)
- Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion (2020) (161)
- Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors (2011) (159)
- Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. (2019) (156)
- Altered metabolism in cancer (2010) (153)
- Dysregulated metabolism contributes to oncogenesis. (2015) (152)
- The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons (2019) (151)
- The evolving metabolic landscape of chromatin biology and epigenetics (2020) (148)
- Paracrine Wnt5a‐&bgr;‐Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization (2018) (148)
- A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. (2017) (136)
- Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (2014) (135)
- Metabolomics in cancer research and emerging applications in clinical oncology (2021) (134)
- Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism (2018) (131)
- Dietary methionine influences therapy in mouse cancer models and alters human metabolism (2019) (128)
- Purine synthesis promotes maintenance of brain tumor initiating cells in glioma (2017) (125)
- Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing (2020) (125)
- Characterization of the usage of the serine metabolic network in human cancer. (2014) (120)
- Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. (2015) (119)
- mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis (2018) (118)
- PHGDH amplification and altered glucose metabolism in human melanoma (2011) (116)
- Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment1 (2015) (113)
- Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation* (2015) (112)
- Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism (2018) (110)
- Antigen receptor control of methionine metabolism in T cells (2018) (106)
- A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity (2019) (105)
- The rate of glycolysis quantitatively mediates specific histone acetylation sites (2015) (100)
- Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway (2018) (97)
- The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. (2007) (97)
- Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function (2012) (96)
- ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. (2016) (93)
- Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. (2017) (93)
- p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. (2018) (90)
- Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma* (2012) (88)
- Epigenetics and cancer metabolism. (2015) (87)
- Rapidly Proliferating Cells Evidence for an Alternative Glycolytic Pathway in (2010) (86)
- Acetate Metabolism in Physiology, Cancer, and Beyond. (2019) (86)
- Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses (2019) (85)
- Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. (2017) (82)
- Interactions between epigenetics and metabolism in cancers (2012) (80)
- MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 (2019) (80)
- High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet* (2015) (78)
- Scaffold proteins confer diverse regulatory properties to protein kinase cascades (2007) (78)
- Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. (2017) (74)
- Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width (2018) (72)
- Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1 (2019) (72)
- Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. (2015) (71)
- NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism (2020) (71)
- Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells (2019) (69)
- Correction to: 'The Warburg Effect: How Does it Benefit Cancer Cells?': [Trends in Biochemical Sciences, 41 (2016) 211]. (2016) (68)
- Extraction parameters for metabolomics from cultured cells. (2015) (67)
- Understanding metabolism with flux analysis: From theory to application. (2017) (66)
- Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord (2017) (65)
- Sirtuin 5 is required for mouse survival in response to cardiac pressure overload (2017) (57)
- Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide (2013) (57)
- Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis (2014) (55)
- Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer. (2020) (53)
- Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells (2018) (49)
- Cancer's insatiable appetite (2009) (47)
- Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development (2017) (47)
- The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. (2016) (46)
- FOXO protects against age‐progressive axonal degeneration (2017) (43)
- A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. (2016) (43)
- IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3 (2016) (42)
- SPHK1 Is a Novel Target of Metformin in Ovarian Cancer (2019) (42)
- Metabolic interactions with cancer epigenetics. (2017) (41)
- Heterogeneity of glycolysis in cancers and therapeutic opportunities. (2014) (40)
- A metabolic signature of colon cancer initiating cells (2014) (39)
- Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism (2016) (39)
- IDH3α regulates one-carbon metabolism in glioblastoma (2019) (39)
- Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice (2017) (39)
- Signatures of protein-DNA recognition in free DNA binding sites. (2009) (38)
- Human pluripotent stem cells decouple respiration from energy production (2011) (38)
- Maximum Entropy Reconstructions of Dynamic Signaling Networks from Quantitative Proteomics Data (2009) (37)
- HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer (2020) (37)
- Genetic selection for enhanced serine metabolism in cancer development (2011) (37)
- Revisiting the Warburg Effect: Some Tumors Hold Their Breath. (2018) (36)
- The Molecular Link from Diet to Cancer Cell Metabolism. (2020) (36)
- Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer (2020) (35)
- A Fundamental Trade-off in Covalent Switching and Its Circumvention by Enzyme Bifunctionality in Glucose Homeostasis* (2014) (35)
- Tumor-induced reshuffling of lipid composition on the ER membrane sustains macrophage survival and pro-tumorigenic activity (2021) (34)
- Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. (2018) (33)
- A strategy for sensitive, large scale quantitative metabolomics. (2014) (33)
- Histone Lactylation: A New Role for Glucose Metabolism. (2019) (32)
- Rewiring of glycolysis in cancer cell metabolism (2010) (30)
- Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow. (2016) (29)
- Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. (2019) (29)
- Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells (2015) (28)
- Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion (2020) (27)
- Metabolic rewiring drives resistance to targeted cancer therapy (2012) (26)
- A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data (2014) (26)
- mTORC 1 and mTORC 2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation (2016) (25)
- Quantitative analysis of the physiological contributions of glucose to the TCA cycle (2019) (25)
- New concepts in feedback regulation of glucose metabolism. (2018) (22)
- Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer (2018) (22)
- Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload (2018) (22)
- A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer (2020) (21)
- Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins (2008) (21)
- The consequences of enhanced cell-autonomous glucose metabolism (2012) (21)
- Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer. (2020) (21)
- Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis (2019) (21)
- Signal duration and the time scale dependence of signal integration in biochemical pathways (2008) (20)
- Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells (2019) (19)
- Differential response to exercise in claudin-low breast cancer (2017) (18)
- SGK1 Signaling Promotes Glucose Metabolism and Survival in Extracellular Matrix Detached Cells (2020) (18)
- RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards (2017) (18)
- p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. (2018) (18)
- Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin (2020) (17)
- Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo (2016) (17)
- Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases (2018) (17)
- Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer (2019) (16)
- Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding. (2007) (15)
- Metabolic regulation of epigenetic remodeling in immune cells. (2020) (15)
- Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays. (2019) (15)
- Estimating Relative Changes of Metabolic Fluxes (2014) (15)
- Computational approaches for understanding energy metabolism (2013) (14)
- SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease (2020) (14)
- Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life (2019) (13)
- Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification (2020) (13)
- Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila (2022) (12)
- Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape. (2016) (12)
- PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart (2021) (12)
- Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer. (2019) (12)
- Anastasiou Contributes to Cellular Antioxidant Responses Inhibition of Pyruvate Kinase M 2 by Reactive Oxygen Species (2012) (12)
- Metabolism in the tumor microenvironment: insights from single-cell analysis (2020) (12)
- Thermodynamic constraints on the regulation of metabolic fluxes (2018) (12)
- Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice (2016) (11)
- Molecular features that predict the response to antimetabolite chemotherapies (2017) (11)
- Computational Investigations into the Origins of Short-Term Biochemical Memory in T cell Activation (2007) (10)
- Metabolism: A new layer of glycolysis. (2016) (10)
- Metabolic pattern formation in the tumor microenvironment (2017) (10)
- Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis (2019) (9)
- Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line (2021) (9)
- Dietary methionine restriction targets one carbon metabolism in humans and produces broad therapeutic responses in cancer (2019) (8)
- Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis (2014) (8)
- ERRa-Regulated Lactate M etabolism Contributes to Resistance to Targeted Therapies in Breast Cancer (2016) (8)
- Context-dependent utilization of serine in cancer (2015) (8)
- Metabolomics reveals intratumor heterogeneity – Implications for precision medicine (2017) (7)
- Targeting metabolism to influence aging (2021) (7)
- The Molecular Link from Diet to Cancer Cell Metabolism. (2020) (7)
- Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays (2019) (7)
- Cellular Control Mechanisms that Regulate Pyruvate Kinase M 2 Activity and Promote Cancer Growth (2012) (7)
- Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation (2021) (7)
- Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney (2020) (6)
- A Missing Link to Vitamin B12 Metabolism (2017) (6)
- The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer (2021) (6)
- Serum metabolomics of Alaskan sled dogs during endurance racing (2018) (6)
- Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin (2020) (5)
- Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine (2021) (4)
- Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis (2017) (4)
- Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration (2020) (4)
- Metabolic landscape of the tumor microenvironment (2019) (3)
- Metabolomics: insights into plant‐based diets (2021) (3)
- Extraction parameters for metabolomics from cell extracts (2015) (3)
- Maximizing the efficacy of angiogenesis inhibitors. (2012) (3)
- Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses (2019) (3)
- Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation (2021) (3)
- Metabolic adaptations underlie epigenetic vulnerabilities in chemoresistant breast cancer (2018) (3)
- Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2‐mediated Enhancement of Anabolic Synthesis (2019) (3)
- Dietary methionine restriction impairs anti-tumor immunity through gut microbiota (2021) (3)
- Epigenomic links from metabolism-methionine and chromatin architecture. (2021) (3)
- A reactive metabolite as an immune suppressant (2020) (2)
- Protein hyperacylation links mitochondrial dysfunction with nuclear organization (2020) (2)
- Dietary Methionine in T Cell Biology and Autoimmune Disease. (2020) (2)
- Metabolic decisions in development and disease—a Keystone Symposia report (2021) (2)
- Acetate is generated de novo from glucose metabolism in mammals and is coupled to central carbon metabolism (2018) (2)
- MNK2 deficiency potentiates β-cell regeneration via translational regulation (2022) (2)
- Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers. (2021) (2)
- Three-state kinetic mechanism for scaffold-mediated signal transduction. (2008) (2)
- The Lipid Kinase PI 5 P 4 K b Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis Graphical (2016) (2)
- The Na+/K+ ATPase Regulates Glycolysis and Modifies Immune Metabolism in Tumors (2020) (2)
- Teleological Role of L-2-Hydroxyglutarate Dehydrogenase in the Kidney. (2020) (2)
- Biochemistry: A toxin that fuels metabolism (2017) (2)
- Digoxin Targets Central Carbon Metabolism and Remodels the Tumor Microenvironment (2020) (2)
- 13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo (2022) (2)
- IL-6 and Ovarian Cancer—Letter (2011) (2)
- Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product (2018) (1)
- Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue (2011) (1)
- Diet and Exercise in Cancer Metabolism (2022) (1)
- A spoonful of DHAP keeps mTORC1 running on sugars (2020) (1)
- TGF-β signaling suppresses TCA cycle metabolism in renal cancer (2021) (1)
- Cooperative virus propagation in COVID-19 transmission (2020) (1)
- NRF2-dependent metabolic reprogramming is required for tumor recurrence following oncogene inhibition (2019) (1)
- Quantitative evaluation of a high resolution lipidomics platform (2019) (1)
- Design principles of mammalian signaling networks : emergent properties at modular and global scales (2008) (1)
- Environmental factors shape methionine metabolism in p16/MTAP deleted cells (2018) (1)
- Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. (2020) (1)
- Amino acid variability, tradeoffs and optimality in human diet (2021) (1)
- Evolved resistance to GAPDH inhibition results in loss of the Warburg Effect but retains a different state of glycolysis (2019) (1)
- Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells (2018) (1)
- Histone Methylation-Adenosylmethionine and S Influence of Threonine Metabolism on (1)
- Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics (2020) (1)
- Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer (2021) (0)
- Abstract IA18: Cancer metabolism: Emerging insights from single cell analysis (2022) (0)
- mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis (2018) (0)
- Webinar | Deciphering cancer: The intersection of epigenetics, metabolism, and tumorigenesis (2017) (0)
- PD17-08 EPIGENETIC AND EPITRANSCRIPTOMIC REPROGRAMMING IN RENAL CANCER BY ONCOMETABOLITE L-2HG CREATES METABOLIC VULNERABILITY (2023) (0)
- Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer. (2023) (0)
- Sel1L is Indispensable for Mammalian ERAD, ER Homeostasis and Survival (2013) (0)
- A reactive metabolite as an immune suppressant (2020) (0)
- Abstract 3705: L-2HG, oncometabolite-driven epigenetic and epitranscriptomic reprogramming creates metabolic vulnerability in renal cancer (2023) (0)
- 13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo (2022) (0)
- Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width (2018) (0)
- Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism (2019) (0)
- Abstract 5474: Activity of the S1P pathway promotes ovarian cancer and serves as a novel metabolic target of metformin (2018) (0)
- 13C tracer analysis identifies extensive recycling of endogenous CO2 in vivo (2021) (0)
- Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila (2022) (0)
- Abstract B18: ADSL controls pyrimidine metabolism and triple-negative breast tumorigenesis (2018) (0)
- 5'-D(*GP*CP*AP*GP*AP*CP*GP*TP*CP*TP*GP*C)-3' Methionine Repressor binding site (2005) (0)
- Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing (2020) (0)
- Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion (2020) (0)
- Crystal structure of PIP4KIIBETA complex with AMP (2015) (0)
- Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism (2018) (0)
- Cell Cycle and Senescence Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC 2-De fi cient Cells to the Antimetabolite 6-Aminonicotinamide (2013) (0)
- Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width (2018) (0)
- Dietary methionine influences therapy in mouse cancer models and alters human metabolism (2019) (0)
- Fibroblasts Mobilize Tumo r Cell Glycogen to Promote Proliferation and Metastasis Graphical Abstract Highlights (2018) (0)
- Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor (2022) (0)
- Regulation of urea cycle by reversible high stoichiometry lysine succinylation (2022) (0)
- Jason Locasale Faculty Bio (2015) (0)
- A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues. (2010) (0)
- Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo (2015) (0)
- Cancer Metabolism (2020) (0)
- De novo acetate production is coupled to central carbon metabolism in mammals (2018) (0)
- Melanoma Therapeutic St rategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence Graphical (2017) (0)
- Estimating Relative Changes of Metabolic Fluxes using Kinetic Flux Profiling (2014) (0)
- NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism (2020) (0)
- A metabolic signature of colon cancer initiating cells (2014) (0)
- Crystal structure of PIP4KIIBETA T201M complex with AMP (2015) (0)
- Human melanoma metabolic network analysis with combined 13C NMR/bioreactor technique: testing the Warburg effect (2013) (0)
- Predictive targeting of mitochondrial metabolism in Acute Myeloid Leukemia patients with a lipoic acid analog (2021) (0)
- Crystal structure of PIP4KIIBETA complex with AMPPNP (2015) (0)
- Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes (2015) (0)
- Paracrine Wnt 5 a-b-Cateni n Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization Graphical (2018) (0)
- Integrated Metabolic and Gene Expression Profiling Reveals New Therapeutic Modalities for Rapidly Proliferating Breast Cancers (2021) (0)
- The rate of glycolysis quantitatively mediates specific histone acetylation sites (2015) (0)
- Abstract 415: Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-mediated Enhancement of Anabolic Synthesis (2018) (0)
- Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer (2020) (0)
- Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion (2020) (0)
- Assisted Living in the Atheroma : Elderly Macrophages Promote Plaques (0)
- Abstract 388: p16/MTAP status as a model for investigating gene-environment interactions in metabolism (2018) (0)
- Abstract 5709: Disruption of mitochondrial metabolism underlies the efficacy of devimistat in acute myeloid leukemia (2020) (0)
- FOXO protects against age# progressive axonal degeneration The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2018) (0)
- 756 - Transcriptional regulation of prostate cancer metabolism (2016) (0)
- Integrated Metabolic Profiling and Gene Expression Analysis Reveals Therapeutic Modalities in Breast Cancer (2020) (0)
- Integrative modeling of tumor DNA methylation identifies a role for metabolism (2016) (0)
- Abstract 5497: Effective combination therapy for breast cancer targeting BACH1 and mitochondrial metabolism (2018) (0)
- Molecular features that predict the response to antimetabolite chemotherapies (2017) (0)
- Crystal structure of PIP4KIIBETA (2015) (0)
- Crystal structure of PIP4KIIBETA N203A complex with AMP (2015) (0)
- CORRECTIONS (2003) (0)
- Ras Activity Regulation by Monoubiquitination (2013) (0)
- A Genome-wide Haploid G enetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity Graphical (2019) (0)
- Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer (2018) (0)
- MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 (2019) (0)
- Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila (2020) (0)
- Crystal structure of PIP4KIIBETA F205L complex with AMP (2015) (0)
- Metabolic Adaptation to Tyrosine Kinase Inhibition in Chronic Myelogenous Leukemia Stem Cells (2022) (0)
- Erratum: Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 5, (E582-E591) doi:10.1073/pnas.1318114111) (2014) (0)
- Nucleotide metabolism is linked to cysteine availability during ferroptosis. (2023) (0)
- Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer. (2016) (0)
- Supplemental Information Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity (0)
- Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses (2019) (0)
- Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells (2018) (0)
- Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers (2022) (0)
- Importance of signal duration and the time scale dependence of signal integration in biochemical networks (2008) (0)
- Nucleotide metabolism is linked to cysteine availability (2022) (0)
- Crystal structure of PIP4KIIBETA I368A complex with AMP (2015) (0)
- Abstract 5428: Rewiring of glucose metabolism in cancer. (2013) (0)
This paper list is powered by the following services:
Other Resources About Jason Locasale
What Schools Are Affiliated With Jason Locasale?
Jason Locasale is affiliated with the following schools:
