Jean Beggs

Q: What Schools Are Affiliated With Jean Beggs

Jean Beggs is affiliated with the following schools: Imperial College London, Massachusetts Institute of Technology, University of Edinburgh, University of Glasgow

Jean Beggs's AcademicInfluence.com Rankings

Jean Beggs

Biology

#3092

World Rank

#4779

Historical Rank

Genetics

#1184

World Rank

#1284

Historical Rank

biology Degrees

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Biology

Why Is Jean Beggs Influential?

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According to Wikipedia, Jean Duthie Beggs CBE FRS FRSE DSc is a Scottish geneticist. She is the Royal Society Darwin Trust Professor in the Wellcome Trust Centre for Cell Biology at the University of Edinburgh. Biography Beggs was born Jean Duthie Lancaster on 16 April 1950 to Jean Crawford and William Renfrew Lancaster. She attended Glasgow High School for Girls. She graduated from the University of Glasgow with a BSc in Biochemistry in 1971, and received her PhD from the University in 1974. From 1974-1977 she held a postdoctoral position in the Department of Molecular Biology at the University of Edinburgh working with Professors Kenneth and Noreen Murray. Having received a Beit Memorial Fellowship for Medical Research, Beggs moved to the Plant Breeding Institute in Cambridge, working there for two years. In 1979, she began work as a lecturer in the Department of Biochemistry at Imperial College London. In 1985, Beggs returned to the University of Edinburgh's Molecular Biology department at Edinburgh, where she was appointed Professor of Molecular Biology in 1999.

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Jean Beggs's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Transformation of yeast by a replicating hybrid plasmid (1978) (1134)
Yeast Sm-like proteins function in mRNA decapping and decay (2000) (444)
Prp8 protein: at the heart of the spliceosome. (2005) (340)
Cross-linking, ligation, and sequencing of hybrids reveals RNA–RNA interactions in yeast (2011) (266)
Characterization of Sm‐like proteins in yeast and their association with U6 snRNA (1999) (253)
Splicing-Dependent RNA Polymerase Pausing in Yeast (2010) (242)
A role for Q/N-rich aggregation-prone regions in P-body localization (2008) (228)
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins (2000) (220)
Extensive interactions of PRP8 protein with the 5′ and 3′ splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA. (1995) (170)
Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. (2001) (164)
Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions (1987) (139)
Identification and characterization of Uss1p (Sdb23p): a novel U6 snRNA‐associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins. (1995) (134)
Vac14 Controls PtdIns(3,5)P 2 Synthesis and Fab1-Dependent Protein Trafficking to the Multivesicular Body (2002) (132)
Characterization of U6 snRNA-protein interactions. (1999) (119)
Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. (2000) (119)
Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil. (1990) (119)
A suppressor of a yeast splicing mutation (prp8-l) encodes a putative ATP-dependent RNA helicase (1991) (115)
Lsm proteins and RNA processing. (2005) (114)
Interaction between a G-Patch Protein and a Spliceosomal DEXD/H-Box ATPase That Is Critical for Splicing (2004) (113)
snRNA interactions at 5' and 3' splice sites monitored by photoactivated crosslinking in yeast spliceosomes. (1995) (109)
prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast (2007) (105)
The construction in vitro of transducing derivatives of phage lambda (1976) (105)
Activation of mitomycin C by NADPH:cytochrome P-450 reductase. (1990) (100)
Roles of PRP8 protein in the assembly of splicing complexes. (1992) (96)
RNA helicases in splicing (2013) (94)
Structure, function and regulation of spliceosomal RNA helicases. (2012) (91)
A dominant negative mutation in the conserved RNA helicase motif ‘SAT’ causes splicing factor PRP2 to stall in spliceosomes. (1994) (89)
PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle (1989) (89)
Abnormal expression of chromosomal rabbit β-globin gene in Saccharomyces cerevisiae (1980) (86)
Dhr1p, a Putative DEAH-Box RNA Helicase, Is Associated with the Box C+D snoRNP U3 (2000) (82)
Lsm Proteins Are Required for Normal Processing and Stability of Ribosomal RNAs* (2003) (82)
A Splicing-Dependent Transcriptional Checkpoint Associated with Prespliceosome Formation (2014) (82)
Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein (1989) (76)
The U6 gene of Saccharomyces cerevisiae is transcribed by RNA polymerase C (III) in vivo and in vitro. (1990) (75)
Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing. (1995) (75)
Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast (2018) (72)
Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning. (2012) (70)
Interactions of PRP2 protein with pre-mRNA splicing complexes in Saccharomyces cerevisiae. (1990) (70)
The product of the PRP4 gene of S. cerevisiae shows homology to β subunits of G proteins (1989) (68)
Lsm Proteins Are Required for Normal Processing of Pre-tRNAs and Their Efficient Association with La-Homologous Protein Lhp1p (2002) (68)
The splicing factor PRP2, a putative RNA helicase, interacts directly with pre‐mRNA. (1994) (66)
Nuclear Pre-mRNA Decapping and 5′ Degradation in Yeast Require the Lsm2-8p Complex (2004) (65)
Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA splicing (1988) (64)
A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP‐dependent RNA helicase (1991) (62)
Extraordinary sequence conservation of the PRP8 splicing factor (1995) (62)
Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors. (2003) (61)
Yeast Ntr1/Spp382 Mediates Prp43 Function in Postspliceosomes (2006) (61)
Transcriptome-wide RNA processing kinetics revealed using extremely short 4tU labeling (2015) (60)
RNA Splicing: U2 fulfils a commitment (1994) (59)
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. (1998) (58)
Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. (2000) (58)
Lsm Proteins Promote Regeneration of Pre-mRNA Splicing Activity (2004) (57)
Cross-talk in transcription, splicing and chromatin: who makes the first call? (2010) (56)
RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3'-end processing in Saccharomyces cerevisiae. (2010) (54)
Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome. (2009) (53)
Affinity purification of spliceosomes reveals that the precursor RNA processing protein PRP8, a protein in the U5 small nuclear ribonucleoprotein particle, is a component of yeast spliceosomes. (1990) (51)
A complex pathway for 3' processing of the yeast U3 snoRNA. (2003) (50)
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. (1998) (46)
The identification and characterization of a novel splicing protein, Isy1p, of Saccharomyces cerevisiae. (1999) (45)
A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein. (1990) (43)
Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control. (1998) (41)
Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression. (2000) (41)
Mechanism for Aar2p function as a U5 snRNP assembly factor. (2011) (40)
The Lsm2-8 complex determines nuclear localization of the spliceosomal U6 snRNA (2007) (39)
The yeast PRP8 protein interacts directly with pre-mRNA. (1991) (39)
Extremely fast and incredibly close: co-transcriptional splicing in budding yeast (2016) (36)
Prp8p dissection reveals domain structure and protein interaction sites. (2005) (36)
Prognosis for splicing factor PRPF8 retinitis pigmentosa, novel mutations and correlation between human and yeast phenotypes (2010) (35)
Splicing goes global. (2003) (33)
Brr2p RNA helicase with a split personality: insights into structure and function. (2010) (31)
Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes (2007) (31)
Evolutionary conservation of the spliceosomal protein, U2B''. (1991) (30)
A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA (2018) (29)
Structural basis for dual roles of Aar2p in U5 snRNP assembly. (2013) (28)
Modelling Reveals Kinetic Advantages of Co-Transcriptional Splicing (2011) (28)
Polypeptide components of Drosophila small nuclear ribonucleoprotein particles. (1991) (27)
Aberrant splicing of Drosophila alcohol dehydrogenase transcripts in Saccharomyces cerevisiae. (1983) (26)
The role of PRP8 protein in nuclear pre-mRNA splicing in yeast (1995) (24)
The expression of cytochrome P450IIB1 in Saccharomyces cerevisiae results in an increased mutation frequency when exposed to cyclophosphamide. (1989) (24)
Regulation of synthesis of benzyl alcohol dehydrogenase in Acinetobacter calcoaceticus NCIB8250. (1977) (23)
Kinetic analysis of pre-ribosome structure in vivo. (2012) (22)
Cloning of the RNA2 gene of Saccharomyces cerevisiae. (1984) (20)
A fast and tuneable auxin‐inducible degron for depletion of target proteins in budding yeast (2018) (18)
Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8. (2009) (17)
Yeast Splicing Factors and Genetic Strategies for Their Analysis (1995) (17)
Production of cytochrome P450 reductase yeast-rat hybrid proteins in Saccharomyces cerevisiae. (1992) (16)
RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit (2017) (16)
Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase (2014) (15)
Cloning and characterisation of the gene encoding the ribosomal protein S5 (also known as rp14, S2, YS8) of Saccharomyces cerevisiae. (1995) (15)
Heterologous expression of drug-metabolizing enzymes in cellular and whole animal models. (1993) (13)
Detection of a plant protein analogous to the yeast spliceosomal protein, PRP8 (1993) (13)
Cwc21p promotes the second step conformation of the spliceosome and modulates 3′ splice site selection (2015) (13)
Dhr 1 p , a Putative DEAH-Box RNA Helicase , Is Associated with the Box C + D snoRNP U 3 (2000) (12)
Interaction of yeast eIF4G with spliceosome components: Implications in pre-mRNA processing events (2009) (12)
Identification of the RNA2 protein of Saccharomyces cerevisiae (1986) (11)
Regulation of growth of Acinetobacter calcoaceticus NCIB8250 on L-mandelate in batch culture. (1975) (11)
Crosstalk between RNA metabolic pathways: an RNOMICS approach (2005) (10)
A map of the restriction targets in yeast 2 micron plasmid DNA cloned on bacteriophage lambda (1976) (10)
Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast (2009) (10)
Spt5 modulates cotranscriptional spliceosome assembly in Saccharomyces cerevisiae (2019) (9)
Processivity and Coupling in Messenger RNA Transcription (2010) (9)
Molecular Cell Splicing-Dependent RNA Polymerase Pausing in Yeast (2010) (8)
Agrobacterium tumefaciens T-DNA in the yeast Saccharomyces cerevisiae (1984) (7)
The yeast nucleus (2000) (7)
Branched poly-labelled oligonucleotides: enhanced specificity of fork-shaped biotinylated oligoribonucleotides for antisense affinity selection. (1993) (7)
The Lsm 2-8 complex determines nuclear localization of the spliceosomal U 6 snRNA (2007) (7)
Regulation of growth of Acinetobacter calcoaceticus NCIB8250 on benzyl alcohol in batch culture. (1976) (7)
A rule-based kinetic model of RNA polymerase II C-terminal domain phosphorylation (2013) (6)
The genetics of nuclear pre-mRNA splicing: a complex story (1992) (6)
SYNTHESIS OF RABBIT β-GLOBIN-SPECIFIC RNA IN MOUSE L CELLS AND YEAST TRANSFORMED WITH CLONED RABBIT CHROMOSOMAL β-GLOBIN DNA (1979) (5)
Repression of the Enzymes Converting Benzyl Alcohol into Benzoate in Acinetobacter calcoaceticus N.C.I.B. 8250 (1974) (5)
Yeast protein splicing factors involved in nuclear pre-mRNA splicing (1993) (4)
STUDIES IN MOTOR VEHICLE REAR VISION: II, EVALUATION OF INNOVATIONS IN PASSENGER CAR AND TRUCK REAR VIEW SYSTEMS (1974) (3)
Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU). (2019) (3)
Genetic Studies of Pre-mRNA Splicing in Yeast (1992) (3)
Blocking late stages of splicing quickly limits pre-spliceosome assembly in vivo (2019) (3)
Pre-mRNA Splicing (2013) (3)
Tuning Degradation to Achieve Specific and Efficient Protein Depletion. (2019) (2)
Revisiting the window of opportunity for cotranscriptional splicing in budding yeast (2020) (2)
Mandelate dehydrogenase with altered stereospecificity in mutant strains of Acinetobacter calcoaceticus N.C.I.B. 8250. (1976) (1)
Protein interactions in nuclear pre-mRNA splicing in Saccharomyces cerevisiae (2004) (1)
Activation of Mitomycin C by NADPH : Cytochrome P-450 ReducÃ-ase 1 (2006) (1)
Yeast Genetics to Investigate the Function of Core Pre-mRNA Splicing Factors (2012) (1)
Nuclear Pre-mRNA Decapping and 5 (cid:2) Degradation in Yeast Require the Lsm2-8p Complex (2004) (0)
The complexity of transferring genetic information. (2023) (0)
Conditional depletion of transcriptional kinases Ctk1 and Bur1 and effects on co-transcriptional spliceosome assembly and pre-mRNA splicing (2021) (0)
Edinburgh Research Explorer Spt5 modulates co-transcriptional spliceosome assembly in Saccharomyces cerevisiae (2019) (0)
Identification of a snRNP protein in Saccharomyces cerevisiae (1987) (0)
Nuclear pre-mRNA splicing in Saccharomyces cerevisiae. (1989) (0)
RNA-protein interactions in nuclear pre-mRNA splicing (1999) (0)
MATERIALS AND METHODS Cell growth and preparation of nuclear extracts The Drosophila melanogaster (2005) (0)
Prognosis for splicing factor PRPF8 Retinitis pigmentosa and correlation between human and yeast phenotypes (2009) (0)
Reviewer list for 1995 (1995) (0)
Mutagenesis of Snu114 domain IV identifies a developmental role in meiotic splicing (2019) (0)
The spliceosome and the regulation of alternative splicing. (2016) (0)
Prognosis for PRPF-RP and Correlation of Phenotype Severity Between Humans and Yeast With the Same Mutations, Suggesting a Common Mechanism (2009) (0)
Erratum (2016) (0)
Splicing-Dependent RNAPolymerase Pausing in Yeast (2010) (0)
Cloning and characterisation of the gene encoding the ribosomal protein S 5 ( also known as rpl 4 , S 2 , YS 8 ) of Saccharomyces cerevisiae (0)
Explorer Processivity and Coupling in Messenger RNA Transcription (2017) (0)
THE EXPRESSION OF A CLONED RABBIT CHROMOSOMAL β-GLOBIN GENE IN MOUSE L CELLS AND YEAST (1979) (0)
Molecular interactions in the yeast spliceosome (2002) (0)
Transcriptome-wide RNA processing kinetics revealed using extremely short 4tU labeling (2015) (0)
Revisiting the window of opportunity for co-transcriptional splicing efficiency and fidelity (2018) (0)
Noreen Elizabeth Murray CBE. 26 February 1935 — 12 May 2011 (2014) (0)
Explorer Splicing-Dependent RNA Polymerase Pausing in Yeast (2017) (0)
Corrigendum: Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast. (2018) (0)
Maudlin 1 Spt 5 modulates co-transcriptional spliceosome assembly in Saccharomyces 1 cerevisiae 2 3 4 5 (2019) (0)
Investigation of mRNA Splicing in Saccharomyces cerevisiae using Microarrays (2005) (0)

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What Schools Are Affiliated With Jean Beggs?

Jean Beggs is affiliated with the following schools: