Jean Chen Shih
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(Suggest an Edit or Addition)According to Wikipedia, Jean Chen Shih is a Chinese-born biochemist. Shih was born Chen Jinghong in China, the second of four children to an engineer father. Her mother came from a wealthy family. At the age of eight, she moved to Taiwan with her family. She studied biochemistry at National Taiwan University and earned her doctorate in the subject via a joint program at the University of California in Riverside and Los Angeles. Upon completing post doctoral research at UCLA, she began teaching at the School of Pharmacy at the University of Southern California in 1974, where she was eventually appointed Boyd and Elsie Welin Professor of Molecular Pharmacology and Toxicology. Shih became known for her research into monoamine oxidase. She became a member of Academia Sinica in 2002. In 2013, the USC–Taiwan Center for Translational Research was established, funded by the USC Daniel Tsai Fund for Translation Research in Pharmacy. Shih was named founding director. In 2018, she was inducted as a member of the USC chapter of the National Academy of Inventors.
Jean Chen Shih's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. (1995) (1192)
- Monoamine oxidase: from genes to behavior. (1999) (1109)
- Monoamine oxidase inactivation: from pathophysiology to therapeutics. (2008) (494)
- A transient placental source of serotonin for the fetal forebrain (2011) (465)
- The mouse cortico-striatal projectome (2016) (348)
- Human monoamine oxidase A and B genes exhibit identical exon-intron organization. (1991) (256)
- Monoamine oxidase in neuropsychiatry and behavior. (1999) (240)
- Increased stress response and β–phenylethylamine in MAOB–deficient mice (1997) (234)
- Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults (2007) (225)
- Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload (2010) (184)
- Tissue Distribution of Human Monoamine Oxidase A and B mRNA (1990) (166)
- Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. (2006) (161)
- Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. (2014) (159)
- Glucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1* (2006) (150)
- Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. (1997) (148)
- Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry (1996) (148)
- The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity (2008) (147)
- Substrate and Inhibitor Specificities for Human Monoamine Oxidase A and B Are Influenced by a Single Amino Acid* (2001) (145)
- Promoter organization and activity of human monoamine oxidase (MAO) A and B genes (1992) (141)
- A Spontaneous Point Mutation Produces Monoamine Oxidase A/B Knock-out Mice with Greatly Elevated Monoamines and Anxiety-like Behavior*♦ (2004) (135)
- Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. (2014) (132)
- The human 5-HT2 receptor is encoded by a multiple intron-exon gene. (1992) (130)
- Molecular basis of human MAO A and B. (1991) (124)
- Regulation of monoamine oxidase A by the SRY gene on the Y chromosome (2009) (114)
- Novel monoamine oxidase A knock out mice with human-like spontaneous mutation (2008) (114)
- Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia (1996) (105)
- The Deduced Amino Acid Sequences of Human Platelet and Frontal Cortex Monoamine Oxidase B Are Identical (1993) (104)
- Serotonin2A receptor gene polymorphism in mood disorders (1997) (103)
- Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. (2011) (100)
- Prenatal Exposure to Urban Air Nanoparticles in Mice Causes Altered Neuronal Differentiation and Depression-Like Responses (2013) (100)
- Monoamine oxidase A inhibitor-near-infrared dye conjugate reduces prostate tumor growth. (2015) (99)
- Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization (1997) (99)
- Monoamine oxidase A and A/B knockout mice display autistic-like features. (2013) (99)
- Regulation of MAO-A and MAO-B gene expression. (2004) (98)
- Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. (1993) (97)
- Increased stress response and beta-phenylethylamine in MAOB-deficient mice. (1997) (97)
- Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice (2011) (88)
- Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. (2004) (86)
- Role of MAO A and B in neurotransmitter metabolism and behavior. (1999) (86)
- Striatal Dopamine Metabolism in Monoamine Oxidase B‐Deficient Mice : A Brain Dialysis Study (1999) (81)
- Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A (1999) (80)
- MAO-A and -B gene knock-out mice exhibit distinctly different behavior. (1999) (79)
- Transcriptional regulation and multiple functions of MAO genes (2011) (77)
- Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1* (2002) (74)
- Development and Characterization of Monoclonal Antibodies Specific to the Serotonin 5-HT2A Receptor (1998) (73)
- Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice (2009) (73)
- Analysis of Conserved Active Site Residues in Monoamine Oxidase A and B and Their Three-dimensional Molecular Modeling* (2002) (71)
- Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2019) (69)
- Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1 (1994) (69)
- Dual Functions of Transcription Factors, Transforming Growth Factor-β-inducible Early Gene (TIEG)2 and Sp3, Are Mediated by CACCC Element and Sp1 Sites of Human Monoamine Oxidase (MAO) B Gene* (2004) (69)
- R1, a Novel Repressor of the Human Monoamine Oxidase A* (2005) (61)
- Expression of Functional Human Monoamine Oxidase A and B cDNAs in Mammalian Cells (1989) (59)
- Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B (2001) (58)
- Effects of Carboxyl-terminal Truncations on the Activity and Solubility of Human Monoamine Oxidase B* (2001) (58)
- Hyperserotoninemia and antiserotonin antibodies in autism and other disorders (1992) (57)
- Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol, leading to apoptosis in SH‐SY5Y cells (2006) (56)
- Biochemical effects of the monoamine neurotoxins DSP‐4 and MDMA in specific brain regions of MAO‐B‐deficient mice (2001) (56)
- [3H]1‐[2‐(4‐Aminophenyl)Ethyl]‐4‐(3‐Trifluoromethylphenyl)Piperazine: A Selective Radioligand for 5‐HT1A Receptors in Rat Brain (1986) (53)
- Regulation of human monoamine oxidase B gene by Sp1 and Sp3. (2001) (53)
- Characterization of the human 5-HT2A receptor gene promoter (1995) (53)
- Cloning of a novel monoamine oxidase cDNA from trout liver. (1994) (52)
- Estrogen-related receptors-stimulated monoamine oxidase B promoter activity is down-regulated by estrogen receptors. (2006) (52)
- Decreased Methylation and Transcription Repressor Sp3 Up-regulated Human Monoamine Oxidase (MAO) B Expression during Caco-2 Differentiation* (2003) (52)
- Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. (1998) (52)
- Monoamine oxidase A (MAO A) inhibitors decrease glioma progression (2016) (51)
- NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression (2012) (50)
- Striatal Damage and Oxidative Stress Induced by the Mitochondrial Toxin Malonate Are Reduced in Clorgyline-Treated Rats and MAO-A Deficient Mice (2004) (48)
- No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan (2002) (48)
- Maladaptive defensive behaviours in monoamine oxidase A-deficient mice. (2011) (46)
- Structure and promoter organization of the human monoamine oxidase A and B genes. (1993) (45)
- From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency (2018) (45)
- Forebrain-specific Expression of Monoamine Oxidase A Reduces Neurotransmitter Levels, Restores the Brain Structure, and Rescues Aggressive Behavior in Monoamine Oxidase A-deficient Mice* (2007) (45)
- Transcription Factor E2F-Associated Phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and Simian Virus 40 Promoter Factor 1 (Sp1) Cooperatively Regulate Glucocorticoid Activation of Monoamine Oxidase B (2011) (45)
- Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice (2013) (44)
- Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives (2003) (43)
- Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli. (2006) (43)
- Analysis of the pharmacological and molecular heterogeneity of I(2)-imidazoline-binding proteins using monoamine oxidase-deficient mouse models. (2000) (42)
- Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate (2018) (42)
- Monoamine Oxidases Regulate Telencephalic Neural Progenitors in Late Embryonic and Early Postnatal Development (2010) (42)
- An Extensive Repeat Structure Down‐Regulates Human Monoamine Oxidase A Promoter Activity Independent of an Initiator‐Like Sequence (1997) (42)
- Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. (2003) (41)
- MAO‐B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake (2004) (37)
- Glyceraldehyde-3-Phosphate Dehydrogenase–Monoamine Oxidase B-Mediated Cell Death-Induced by Ethanol is Prevented by Rasagiline and 1-R-Aminoindan (2009) (36)
- MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells (2017) (36)
- Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan (2007) (35)
- Retinoic Acid Activates Monoamine Oxidase B Promoter in Human Neuronal Cells* (2009) (34)
- Influence of C Terminus on Monoamine Oxidase A and B Catalytic Activity (1996) (34)
- Valproic Acid Induces Monoamine Oxidase A via Akt/Forkhead Box O1 Activation (2011) (33)
- The expression of human MAO-A and B genes. (1990) (33)
- Effect of Monoamine oxidase A (MAOA) inhibitors on androgen‐sensitive and castration‐resistant prostate cancer cells (2019) (32)
- Serotonin Catabolism and the Formation and Fate of 5-Hydroxyindole Thiazolidine Carboxylic Acid* (2006) (31)
- Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling (2019) (31)
- Gene structure and expression of the mouse 5‐HT2 receptor (1992) (30)
- Phe208 and Ile199 in Human Monoamine Oxidase A and B Do Not Determine Substrate and Inhibitor Specificities as in Rat (2000) (29)
- The Degradation of Serotonin: Role of MAO (2010) (28)
- The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. (2014) (28)
- Dinucleotide repeat (TG)23 polymorphism in the MAOB gene. (1992) (28)
- Transcription factor binding to the core promoter of the human monoamine oxidase B gene in the cerebral cortex and in blood cells (1998) (27)
- Monoamine oxidase A and B: structure, function, and behavior. (1998) (27)
- Schizophrenia, Monoamine Oxidase Activity, and Cigarette Smoking (1999) (27)
- Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice (1999) (26)
- Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma (2017) (22)
- Phase 2 Trial of Monoamine Oxidase Inhibitor Phenelzine in Biochemical Recurrent Prostate Cancer (2020) (22)
- Molecular biology of serotonin (5-HT) receptors (1991) (22)
- Insights into enzyme point mutation effect by molecular simulation: phenylethylamine oxidation catalyzed by monoamine oxidase A. (2016) (21)
- Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice (2013) (21)
- Determination of transcription initiation sites and promoter activity of the human 5-HT2A receptor gene (1995) (21)
- Photoaffinity Labeling of the 5‐HydroxytryptamineIA Receptor in Rat Hippocampus (1986) (21)
- Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation (2019) (20)
- Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B‐deficient mice (2006) (19)
- Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine (2000) (19)
- Lack of protection from ischemic injury of monoamine oxidase B-deficient mice following middle cerebral artery occlusion (1999) (19)
- Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities. (1998) (19)
- Increased baroreceptor response in mice deficient in monoamine oxidase A and B. (2002) (18)
- Molecular Biology of Monoamine Oxidase A and B: Their Role in the Degradation of Serotonin (2000) (18)
- Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress (2015) (18)
- Heart rate dynamics in monoamine oxidase-A- and -B-deficient mice. (2002) (17)
- Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice (2012) (16)
- A Trifluoromethylphenyl Piperazine Derivative with High Affinity for 5‐Hydroxytryptamine‐1A Sites in Rat Brain (1985) (14)
- Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans (2012) (14)
- Modulation of [3H]quinpirole binding at striatal D2 dopamine receptors by a monoamine oxidaseA-like site: evidence from radioligand binding studies and D2 receptor- and MAO(A)-deficient mice. (2001) (14)
- Interaction of N‐(2‐Nitro‐4‐Azidophenyl)‐Serotonin with Two Types of Monoamine Oxidase in Rat Brain (1984) (14)
- De novo microdeletion of Xp11.3 exclusively encompassing the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine. (2012) (13)
- Ginkgo biloba abolishes aggression in mice lacking MAO A. (2000) (13)
- Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the Morris water maze. (1999) (12)
- TISSUE-SPECIFIC EFFECTS OF ESTROGEN ON MONOAMINE OXIDASE A AND B IN THE RAT (1999) (11)
- Identification of human monoamine oxidase (MAO) A and B gene promoters. (1994) (11)
- Monoamine oxidase gene transcription in human cell lines: Treatment with psychoactive drugs and ethanol (2005) (10)
- Yang-Gan-Wan protects mice against experimental liver damage. (2000) (10)
- Expression of human monoamine oxidase (MAO) A gene controlled by transcription factor Sp1. (1995) (10)
- Altered Expression of Tyrosine Hydroxylase in the Locus Coeruleus Noradrenergic System in Citalopram Neonatally Exposed Rats and Monoamine Oxidase A Knock Out Mice (2011) (10)
- Monoamine Oxidases: From Tissue Homogenates to Transgenic Mice (2007) (9)
- Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites (1983) (9)
- Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. (1998) (9)
- R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc (2018) (8)
- Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells (2011) (7)
- Binding of the Imidazoline Ligand3H‐2‐Benzofuranyl‐2‐Imidazoline (BFI) to Human Brain and Platelets: Potentiation by Tranylcypromine and Role of MAO Isoforms (1999) (7)
- PAMs inhibits monoamine oxidase a activity and reduces glioma tumor growth, a potential adjuvant treatment for glioma (2020) (7)
- Down-Regulated GABAergic Expression in the Olfactory Bulb Layers of the Mouse Deficient in Monoamine Oxidase B and Administered With Amphetamine (2010) (6)
- PSYCHIATRIC GENETICS '99 Monoamine Oxidase in Neuropsychiatry and Behavior (1999) (6)
- Structure and function of serotonin 5-HT2 receptors. (1994) (6)
- Inhibition of Monoamine Oxidase by Phenyl Azides (1985) (6)
- N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment. (2022) (5)
- The circadian rhythm of 5-HT biosynthetic and degradative enzymes in immortalized mouse neuroendocrine pineal cell line--a model for studying circadian rhythm. (2004) (5)
- Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function (2022) (5)
- Near-Infrared Monoamine Oxidase Inhibitor Biodistribution in a Glioma Mouse Model (2021) (4)
- Site-directed mutagenesis of serotonin 5-HT2 receptors (1992) (4)
- Yang-gan-wan protects mice against apoptosis induced by anti-Fas antibody (Jo2). (2000) (4)
- Molecular Studies of 5‐HT Receptors a (1990) (4)
- Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry (2017) (3)
- Altered gene expression in early postnatal monoamine oxidase A knockout mice (2017) (3)
- Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression. (2022) (3)
- Intact 5-HT2A Receptor Exons and the Adjoining Intron Regions in Schizophrenia (1996) (3)
- Identification of 5‐Hydroxytryptamine1A Receptor Proteins in Bovine Frontal Cortex (1988) (3)
- Near-Infrared MAO A Inhibitor (NMI) Outperformed FDA-Approved Chemotherapeutic Agents in Brain and Other Cancers: A Bioinformatic Analysis of NCI60 Screening Data (2021) (2)
- Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice (2021) (2)
- In Vivo and in Vitro Functions of Two Types of Mao (2002) (2)
- Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2020) (2)
- Valproic Acid Induces Monoamine Oxidase A via Akt/FoxO1 Activation (2011) (2)
- NMDA receptors mediate the role of monoamine oxidase A in pathological aggression (2012) (1)
- Adverse Remodeling and Pump Failure in Hearts With Pressure Overload Mediated Enhanced Catabolism of Norepinephrine Contributes to − Monoamine Oxidase (2009) (1)
- Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment (2022) (1)
- Platelet MAO activity in depressed patients (1981) (1)
- Molecular cloning of human monoamine oxidase a and b mao a and b (1988) (1)
- Monoamine Oxidase a (MAO A) Is Expressed Selectively in Reed-Sternberg Cells of Classical Hodgkin Lymphoma (2015) (1)
- Structure and functional expression of cloned human liver MAO A and B (1990) (1)
- Promoter Organization (MAO) A and B Genes and Activity of Human Monoamine Oxidase (1992) (1)
- A novel role for GAPDH-MAO B cascade in ethanol-induced cellular damage (2010) (1)
- Phase II trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. (2020) (1)
- Translation Research in Autism and Cancer: Novel Roles of MAO (2014) (0)
- In Vitro and In Vivo Assays Characterizing MAO A Function in Cancers. (0)
- J. Animal Models Posters (1999) (0)
- Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2020) (0)
- Monoamine oxidase B gene deletion prevents cardiac pump dysfunction in mice with pressure overload (2010) (0)
- P.6.d.015 Altered norepinephrinergic and parvalbumin expression in hippocampal formation of mouse deficient in monoamine oxidase B (2010) (0)
- Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control (2022) (0)
- Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (2019) (0)
- Long Non-Coding RNA PCAT-NE1 Activates Autophagy via miR-6889-3p-Regulated VPS13A to Induce Neuroendocrine Differentiation (2021) (0)
- Study shows role of enzyme in prostate cancer growth (2020) (0)
- The genetic deletion of monoamine oxidase (MAO) gene promotes autistic-like phenotypes in mice (2010) (0)
- Molecular cloning of transcription factor in the regulation of human monoamine oxidase B gene (1999) (0)
- Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer (2020) (0)
- Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions (2023) (0)
- Autoantibody profiling of monoamine oxidase A knockout mice, an autism spectrum disorder model (2022) (0)
- Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT 2A receptor activation (2020) (0)
- Abstract 2959: Pharmacological and Genetic Inhibition of Monoamine Oxidase A Prevents Enhanced Norepinephrine Catabolism and Heart Failure After Pressure Overload (2009) (0)
- Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma (2023) (0)
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