Jean‐charles Fruchart
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Logic
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Jean‐charles Fruchartbiology Degrees
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Philosophy Biology
Jean‐charles Fruchart's Degrees
- PhD Biochemistry Université Paris Cité
- Doctorate Medicine Université Paris Cité
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(Suggest an Edit or Addition)Jean‐charles Fruchart's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International As (2009) (11411)
- Intensive lipid lowering with atorvastatin in patients with stable coronary disease. (2005) (3308)
- Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. (2006) (1952)
- Mechanism of action of fibrates on lipid and lipoprotein metabolism. (1998) (1615)
- The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene* (1997) (1292)
- Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators (1998) (1064)
- An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing (2001) (923)
- Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation (2000) (917)
- Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1* (1999) (917)
- Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages* (1998) (866)
- PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway (2001) (833)
- Peroxisome proliferator-activated receptors in inflammation control. (2001) (777)
- HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. (2007) (767)
- Sorting out the roles of PPARα in energy metabolism and vascular homeostasis (2006) (753)
- Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice (1998) (632)
- Therapeutic roles of peroxisome proliferator-activated receptor agonists. (2005) (624)
- Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity* (2000) (624)
- Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. (2004) (557)
- An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro (1990) (538)
- Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. (1999) (535)
- Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. (2004) (534)
- Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity (2020) (528)
- The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice* (2006) (517)
- The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. (2008) (473)
- Atherogenic Lipoprotein Particles in Atherosclerosis (2004) (472)
- Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice* (1997) (456)
- Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. (1998) (456)
- Cigarette smoking is associated with unhealthy patterns of nutrient intake: a meta-analysis. (1998) (455)
- Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. (2019) (449)
- CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. (2000) (445)
- PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. (2000) (435)
- Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators* (2000) (435)
- Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism (1999) (431)
- Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I. (2001) (428)
- Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. (1995) (423)
- Pleiotropic Actions of Peroxisome Proliferator-Activated Receptors in Lipid Metabolism and Atherosclerosis (2002) (414)
- Effect of Lowering LDL Cholesterol Substantially Below Currently Recommended Levels in Patients With Coronary Heart Disease and Diabetes (2006) (409)
- C-Reactive Protein, Interleukin-6, and Fibrinogen as Predictors of Coronary Heart Disease: The PRIME Study (2003) (409)
- Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. (2006) (404)
- Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. (2003) (396)
- Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study (2006) (383)
- Peroxisome proliterator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis (1999) (382)
- New Risk Factors for Atherosclerosis and Patient Risk Assessment (2004) (346)
- Apolipoprotein A-I containing lipoproteins in coronary artery disease. (1987) (336)
- Cholesterol efflux from cultured adipose cells is mediated by LpAI particles but not by LpAI:AII particles. (1987) (330)
- The Nuclear Receptors Peroxisome Proliferator-activated Receptor α and Rev-erbα Mediate the Species-specific Regulation of Apolipoprotein A-I Expression by Fibrates* (1998) (325)
- PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter (1998) (317)
- Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. (2002) (317)
- Safety issues and prospects for future generations of PPAR modulators. (2007) (288)
- Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation (2003) (287)
- Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid – a position paper developed by the European Consensus Panel on HDL-C* (2004) (265)
- Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice. (1996) (263)
- Increased ABCA1 activity protects against atherosclerosis. (2002) (262)
- The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients (2008) (261)
- Regulation of Lipid and Lipoprotein Metabolism by PPAR Activators (2000) (259)
- Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. (2003) (258)
- PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases. (2006) (253)
- Peroxisome Proliferator-Activated Receptor-α Activation as a Mechanism of Preventive Neuroprotection Induced by Chronic Fenofibrate Treatment (2003) (252)
- Protection Against Atherogenesis in Mice Mediated by Human Apolipoprotein A-IV (1996) (251)
- Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. (1994) (251)
- The role of PPARs in atherosclerosis. (2002) (249)
- Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study (2018) (244)
- Glucose regulates the expression of the farnesoid X receptor in liver. (2004) (242)
- The orphan nuclear receptor RORα is a negative regulator of the inflammatory response (2001) (237)
- Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes (1987) (225)
- Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study. (2002) (225)
- Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits. (1996) (225)
- The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition* (2005) (224)
- Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term Culture (1989) (221)
- Apolipoprotein A5, a Crucial Determinant of Plasma Triglyceride Levels, Is Highly Responsive to Peroxisome Proliferator-activated Receptor α Activators* (2003) (217)
- An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer (1999) (216)
- Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice (2001) (211)
- Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. (2004) (209)
- PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance (2001) (208)
- Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. (2000) (208)
- Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate Consensus Group. (1998) (207)
- The Orphan Nuclear Receptor Rev-Erbα Is a Peroxisome Proliferator-activated Receptor (PPAR) γ Target Gene and Promotes PPARγ-induced Adipocyte Differentiation* (2003) (206)
- Differential electroimmunoassay of human LpA-I lipoprotein particles on ready-to-use plates. (1990) (205)
- p300 Interacts with the N- and C-terminal Part of PPARγ2 in a Ligand-independent and -dependent Manner, Respectively* (1999) (200)
- FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. (2003) (197)
- Reduction of Atherosclerosis by the Peroxisome Proliferator-activated Receptor α Agonist Fenofibrate in Mice* (2002) (195)
- Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. (2000) (194)
- Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease. (2009) (193)
- Transcriptional control of adipogenesis. (1998) (191)
- PPARα Agonists Inhibit Tissue Factor Expression in Human Monocytes and Macrophages (2001) (186)
- Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine. (2006) (183)
- Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. (1999) (183)
- Value of HDL Cholesterol, Apolipoprotein A-I, Lipoprotein A-I, and Lipoprotein A-I/A-II in Prediction of Coronary Heart Disease: The PRIME Study (2002) (182)
- Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models (1992) (181)
- Lipoprotein lipase gene polymorphisms: associations with myocardial infarction and lipoprotein levels, the ECTIM study. Etude Cas Témoin sur l'Infarctus du Myocarde. (1995) (179)
- Adipophilin Enhances Lipid Accumulation and Prevents Lipid Efflux From THP-1 Macrophages: Potential Role in Atherogenesis (2004) (178)
- PPARs: Transcription Factors Controlling Lipid and Lipoprotein Metabolism (2002) (176)
- Modulation of lipoprotein B binding to the LDL receptor by exogenous lipids and apolipoproteins CI, CII, CIII, and E. (1995) (176)
- Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells. (1999) (176)
- Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME Study. (2003) (174)
- In vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpA-I,A-II. (1991) (174)
- Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription. (2002) (174)
- PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome (2006) (170)
- Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element. (2002) (169)
- The role of fibric acids in atherosclerosis (2001) (166)
- Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element. (1999) (165)
- PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a. (2005) (164)
- Inhibition of lipoprotein lipase activity by synthetic peptides of apolipoprotein C-III. (1992) (164)
- Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors (2007) (159)
- Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR. (1996) (158)
- Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment. (2005) (158)
- Residual macrovascular risk in 2013: what have we learned? (2014) (157)
- Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease. (2000) (157)
- Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β* (2001) (153)
- A truncated human peroxisome proliferator-activated receptor alpha splice variant with dominant negative activity. (1999) (153)
- Oxidized phospholipids activate PPARα in a phospholipase A2‐dependent manner (2000) (152)
- Modulation of Hepatic Inflammatory Risk Markers of Cardiovascular Diseases by PPAR–&agr; Activators: Clinical and Experimental Evidence (2006) (151)
- Somatic gene transfer of human ApoA-I inhibits atherosclerosis progression in mouse models. (1999) (149)
- Drug transfer across the blood-brain barrier: Correlation between “in vitro” and “in vivo” models (1992) (146)
- Effects of gender and menopausal status on plasma lipoprotein subspecies and particle sizes. (1996) (145)
- Lp(a) lipoprotein in patients with chronic renal failure treated by hemodialysis. (1987) (145)
- Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids. (1998) (144)
- Acute Antiinflammatory Properties of Statins Involve Peroxisome Proliferator–Activated Receptor-α via Inhibition of the Protein Kinase C Signaling Pathway (2006) (143)
- Effect of pravastatin on angiographic restenosis after coronary balloon angioplasty. The PREDICT Trial Investigators. Prevention of Restenosis by Elisor after Transluminal Coronary Angioplasty. (1997) (142)
- Apolipoprotein A-II, HDL metabolism and atherosclerosis. (2002) (140)
- The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response. (2001) (138)
- Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORα* (2001) (138)
- Transcriptional Regulation of Apolipoprotein A-I Gene Expression by the Nuclear Receptor RORα* (1997) (138)
- Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists (2013) (137)
- Circadian and Glucocorticoid Regulation of Rev-erbα Expression in Liver. (2000) (136)
- Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. (2006) (135)
- Liver X Receptor Activation Controls Intracellular Cholesterol Trafficking and Esterification in Human Macrophages (2005) (135)
- Peroxisome Proliferator-activated Receptor α Induces Hepatic Expression of the Human Bile Acid Glucuronidating UDP-glucuronosyltransferase 2B4 Enzyme* (2003) (134)
- Plasma apolipoprotein A-I, A-II, B, E and C-III containing particles in men with premature coronary artery disease. (1991) (133)
- Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation. (1999) (132)
- PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter. (1998) (132)
- Low‐Density Lipoprotein Receptor on Endothelium of Brain Capillaries (1989) (132)
- Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. (2004) (131)
- Multiple coronary heart disease risk factors are associated with menopause and influenced by substitutive hormonal therapy in a cohort of French women. (1995) (131)
- Plasma cystatin-C and development of coronary heart disease: The PRIME Study. (2006) (126)
- Increased triglyceride levels in shift workers. (1992) (125)
- Apolipoprotein A-containing lipoprotein particles: physiological role, quantification, and clinical significance. (1992) (125)
- The UDP-glucuronosyltransferase 1A9 Enzyme Is a Peroxisome Proliferator-activated Receptor α and γ Target Gene* (2003) (124)
- Peroxisome Proliferator-activated Receptor α (PPARα) Turnover by the Ubiquitin-Proteasome System Controls the Ligand-induced Expression Level of Its Target Genes* (2002) (123)
- Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial. (2016) (123)
- Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective Peroxisome Proliferator–Activated Receptor &agr; Modulation (2005) (122)
- Peroxisome Proliferator-Activated Receptor &agr; Reduces Cholesterol Esterification in Macrophages (2003) (122)
- Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids. (1995) (122)
- Apolipoproteins C-III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: the ECTIM study. Etude Cas Témoins sur 'Infarctus du Myocarde. (1996) (122)
- Oxidation of lipoproteins and atherosclerosis. (1991) (121)
- The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. (2003) (120)
- Peroxisome proliferator-activated receptor-α activation and high-density lipoprotein metabolism☆ (2001) (119)
- PPARS, metabolic disease and atherosclerosis. (2001) (118)
- Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle (1998) (117)
- Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake. (1999) (117)
- Familial hypoalphalipoproteinemia in premature coronary artery disease. (1993) (117)
- PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance. (2001) (116)
- The use of monoclonal antibodies to localize the low density lipoprotein receptor-binding domain of apolipoprotein B. (1989) (115)
- Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor (2005) (114)
- Use of bacterial expression cloning to localize the epitopes for a series of monoclonal antibodies against apolipoprotein B100. (1990) (113)
- Quantification of two different types of apolipoprotein A-I containing lipoprotein particles in plasma by enzyme-linked differential-antibody immunosorbent assay. (1987) (113)
- Influence of serum amyloid A on cholesterol esterification in human plasma. (1989) (111)
- DNA Binding-Independent Induction of IκBα Gene Transcription by PPARα (2002) (110)
- Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects. (1996) (109)
- The farnesoid X receptor induces very low density lipoprotein receptor gene expression (2004) (107)
- Induction of the Phospholipid Transfer Protein Gene Accounts for the High Density Lipoprotein Enlargement in Mice Treated with Fenofibrate* (2001) (107)
- Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets (2006) (106)
- HDLs and alimentary lipemia. Studies in men with previous myocardial infarction at a young age. (1993) (106)
- Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications (2003) (106)
- Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy. (2005) (105)
- Coronary Heart Disease: Reducing The Risk: A Worldwide View (1999) (105)
- Tissue-Specific Roles of ABCA1 Influence Susceptibility to Atherosclerosis (2009) (104)
- Black-white differences in serum Lp(a) lipoprotein levels. (1987) (104)
- Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages (2007) (104)
- Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of Type 2 diabetes and atherosclerosis (2006) (100)
- Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. (2003) (97)
- 3‐Hydroxy‐3‐methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C‐III and lipoprotein lipase (1999) (97)
- PPARa activators improve insulin sensitivity and reduce adiposity (2000) (97)
- Both Hepatic and Extrahepatic ABCA1 Have Discrete and Essential Functions in the Maintenance of Plasma High-Density Lipoprotein Cholesterol Levels In Vivo (2006) (93)
- Peroxisome Proliferator–Activated Receptor &agr; Induces NADPH Oxidase Activity in Macrophages, Leading to the Generation of LDL with PPAR-&agr; Activation Properties (2004) (93)
- Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin (1991) (93)
- Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor alpha modulator for management of atherogenic dyslipidaemia (2017) (92)
- Peroxisome Proliferator–activated Receptor Activators Inhibit Oxidized Low-density Lipoprotein–induced Endothelin-1 Secretion in Endothelial Cells (2002) (92)
- Transient impairment of the adaptive response to fasting in FXR‐deficient mice (2005) (90)
- Immunoelectron microscopy of low density lipoproteins yields a ribbon and bow model for the conformation of apolipoprotein B on the lipoprotein surface. (1995) (90)
- The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia. (2004) (90)
- Human Plasma Lipoproteins (1989) (89)
- Effects of Pinus pinaster and Pinus koraiensis seed oil supplementation on lipoprotein metabolism in the rat (1999) (89)
- The Liver X Receptor Ligand T0901317 Down-regulates APOA5 Gene Expression through Activation of SREBP-1c* (2004) (89)
- Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver. (1994) (88)
- p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. (1999) (88)
- Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function (2003) (88)
- Regulation of Lipoprotein Metabolism by Thiazolidinediones Occurs through a Distinct but Complementary Mechanism Relative to Fibrates (1997) (88)
- Paraoxonase activity is reduced by a pro-atherosclerotic diet in rabbits. (2000) (88)
- The Protein Kinase C Signaling Pathway Regulates a Molecular Switch between Transactivation and Transrepression Activity of the Peroxisome Proliferator-Activated Receptor α (2004) (87)
- Rosuvastatin reduces MMP-7 secretion by human monocyte-derived macrophages: potential relevance to atherosclerotic plaque stability. (2004) (87)
- Apolipoprotein B metabolism in homozygous familial hypercholesterolemia. (1989) (85)
- Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. (2002) (84)
- Peroxisome Proliferator-activated Receptor α Is Not Rate-limiting for the Lipoprotein-lowering Action of Fish Oil* (2001) (84)
- The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential (2019) (84)
- Genetic Determinants of Responsiveness to the HMG‐CoA Reductase Inhibitor Fluvastatin in Patients With Molecularly Defined Heterozygous Familial Hypercholesterolemia (1993) (83)
- Induction of the Fatty Acid Transport Protein 1 and Acyl-CoA Synthase Genes by Dimer-selective Rexinoids Suggests That the Peroxisome Proliferator-activated Receptor-Retinoid X Receptor Heterodimer Is Their Molecular Target* (2000) (83)
- Differential role of apolipoprotein AI-containing particles in cholesterol efflux from adipose cells. (1991) (82)
- Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice (2004) (82)
- Peroxisome proliferator‐activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages (2002) (82)
- Alterations in the main steps of reverse cholesterol transport in male patients with primary hypertriglyceridemia and low HDL-cholesterol levels. (2000) (82)
- Sequential ultracentrifugation micromethod for separation of serum lipoproteins and assays of lipids, apolipoproteins, and lipoprotein particles. (1993) (81)
- Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes (2005) (81)
- Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta. (2001) (80)
- Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid. (1996) (80)
- Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates. (1997) (79)
- The effect of moderate alcohol intake on serum apolipoprotein A-I-containing lipoproteins and lipoprotein (a). (1991) (78)
- Complete atherosclerosis regression after human ApoE gene transfer in ApoE-deficient/nude mice. (2000) (78)
- A selective bi-site immunoenzymatic procedure for human Lp[a] lipoprotein quantification using monoclonal antibodies against apo[a] and apoB. (1989) (77)
- Oxidized phospholipids activate PPARalpha in a phospholipase A2-dependent manner. (2000) (76)
- The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs). (1997) (76)
- Combination lipid therapy in type 2 diabetes. (2010) (75)
- Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity. (2008) (75)
- PPARs in Inflammation, Atherosclerosis and Thrombosis (2001) (75)
- Inhibitory Effects of Specific Apolipoprotein C-III Isoforms on the Binding of Triglyceride-rich Lipoproteins to the Lipolysis-stimulated Receptor* (1997) (75)
- PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages. (2001) (75)
- Circadian and glucocorticoid regulation of Rev-erbalpha expression in liver. (2000) (74)
- Effects of high-dose atorvastatin on cerebrovascular events in patients with stable coronary disease in the TNT (treating to new targets) study. (2006) (73)
- Characterization of apoA-IV-containing lipoprotein particles isolated from human plasma and interstitial fluid. (1993) (71)
- Peroxisome proliferator-activated receptor alpha controls cellular cholesterol trafficking in macrophages. (2005) (71)
- Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of β‐oxidation (2006) (71)
- PPAR&agr;, but not PPAR&ggr;, Activators Decrease Macrophage-Laden Atherosclerotic Lesions in a Nondiabetic Mouse Model of Mixed Dyslipidemia (2005) (71)
- Cholesterol efflux, lecithin-cholesterol acyltransferase activity, and pre-beta particle formation by serum from human apolipoprotein A-I and apolipoprotein A-I/apolipoprotein A-II transgenic mice consistent with the latter being less effective for reverse cholesterol transport. (1997) (70)
- Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation. (1990) (70)
- Interaction of LpB, LpB:E, LpB:C-III, and LpB:C-III:E lipoproteins with the low density lipoprotein receptor of HeLa cells. (1991) (70)
- The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages. (2008) (69)
- Detection of autoantibodies against oxidized low-density lipoproteins and of IgG-bound low density lipoproteins in patients with coronary artery disease. (1995) (68)
- Abnormal reverse cholesterol transport in controlled type II diabetic patients. Studies on fasting and postprandial LpA-I particles. (1995) (68)
- Hepatic Expression of the UGT1A9 Gene Is Governed by Hepatocyte Nuclear Factor 4α (2005) (67)
- The epitopes of apolipoprotein A-I define distinct structural domains including a mobile middle region. (1991) (67)
- The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia (2006) (67)
- Peroxisome proliferator-activated receptors (PPARs): nuclear receptors with functions in the vascular wall (2001) (65)
- Lipoprotein abnormalities in chronic haemodialysis patients. (1988) (65)
- Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency. (1996) (65)
- Circadian variation of postprandial lipemia. (1997) (65)
- Logistic discriminant analysis of lipids and apolipoproteins in a population of coronary bypass patients and the significance of apolipoproteins C-III and E. (1990) (65)
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