Jean-Charles Schwartz

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Chemistry

#1109

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#1761

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Organic Chemistry

#131

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#170

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Jean-Charles Schwartz

Mathematics

#3951

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#5703

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Group Theory

#15

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#21

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Algebra

#60

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#104

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Measure Theory

#275

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#432

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Chemistry
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Jean-Charles Schwartz's Degrees

Masters Mathematics Université Paris Cité

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According to Wikipedia, Jean-Charles Schwartz, born on May 28, 1936, in Paris, is a French neurobiologist, pharmacist and researcher. Husband of Ketty Schwartz, née Gersen and father of Olivier, Marc and Emmanuelle. He is a member of the Academy of Sciences. He developed pitolisant, the first clinically approved antagonist for H3 receptors.

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Jean-Charles Schwartz's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics (1990) (2523)
Formation and inactivation of endogenous cannabinoid anandamide in central neurons (1994) (1548)
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor (1983) (1500)
Histaminergic transmission in the mammalian brain. (1991) (958)
International Union of Pharmacology. XIII. Classification of histamine receptors. (1997) (894)
Highly potent and selective ligands for histamine H3-receptors (1987) (869)
Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA (1991) (867)
Alternative splicing directs the expression of two D2 dopamine receptor isoforms (1989) (690)
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice (1980) (646)
Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin. (1992) (646)
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. (1993) (605)
High-affinity enkephalin-degrading peptidase in brain is increased after morphine (1978) (601)
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization (2001) (569)
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist (1999) (545)
A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. (1993) (413)
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor. (1992) (394)
Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase. (1981) (371)
Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain (1995) (354)
A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with [125I]iodosulpride (1987) (353)
Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa. (1997) (347)
Dopamine D3 Receptors Expressed by All Mesencephalic Dopamine Neurons (2000) (323)
Novel dopamine receptors half a decade later. (1995) (310)
A detailed mapping of the histamine H3 receptor and its gene transcripts in rat brain (2002) (308)
Enkephalin receptors on dopaminergic neurones in rat striatum (1977) (306)
Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence (1980) (286)
Dopamine activation of the arachidonic acid cascade as a basis for D1D2 receptor synergism (1991) (275)
A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas (1993) (273)
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial (2013) (273)
Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand. (1985) (272)
Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors (1987) (263)
Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates (1990) (250)
Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders (1992) (250)
The histamine H3 receptor: from discovery to clinical trials with pitolisant (2011) (250)
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. (1998) (237)
Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. (1992) (236)
D3 dopamine receptor mRNA is widely expressed in the human brain (1998) (235)
An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients (2008) (234)
Autoregulation of histamine release in brain by presynaptic H3-receptors (1985) (230)
A functional test identifies dopamine agonists selective for D3 versus D2 receptors. (1995) (224)
Modulation of receptor mechanisms in the CNS: Hyper-and hyposensitivity to catecholamines (1978) (218)
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H3 Receptor: Preclinical Pharmacology (2007) (215)
Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies (1978) (215)
Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat (1990) (210)
Molecular cloning and characterization of the rat fifth melanocortin receptor. (1994) (209)
Long-term changes in the sensitivity of pre- and postsynaptic dopamine receptors in mouse striatum evidenced by behavioural and biochemical studies (1977) (209)
Histamine as a transmitter in brain. (1975) (207)
Possible implications of the dopamine D3 receptor in schizophrenia and in antipsychotic drug actions (2000) (196)
The third dopamine receptor (D3) as a novel target for antipsychotics. (1992) (185)
Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. (1995) (182)
Role of the dopamine D3 receptor in reactivity to cocaine‐associated cues in mice (2002) (178)
A detailed mapping of hist amine H1-receptors in guinea-pig central nervous system established by autoradiography with [125I]iodobolpyramine (1988) (178)
A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. (1995) (177)
H1 and H2 receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices (1975) (171)
Characterization and inhibition of a cholecystokinin-inactivating serine peptidase (1996) (171)
Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle. (1974) (165)
S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. (1992) (159)
Coexpression of dopamine D1 and D3 receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions (1998) (158)
Functional potencies of new antiparkinsonian drugs at recombinant human dopamine D1, D2 and D3 receptors. (1999) (155)
Actions of betahistine at histamine receptors in the brain. (1985) (154)
The dopamine receptor family: molecular biology and pharmacology (1992) (154)
Catabolism of 3 H-histamine in the rat brain after intracisternal administration. (1971) (152)
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments (2000) (151)
Functional implications of multiple dopamine receptor subtypes: the D1/D3 receptor coexistence 1 Published on the World Wide Web on 24 November 1997. 1 (1998) (148)
Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor. (1986) (146)
Protean agonism at histamine H3 receptors in vitro and in vivo (2003) (145)
H3‐Receptors Control Histamine Release in Human Brain (1988) (143)
Shorter variants of the D3 dopamine receptor produced through various patterns of alternative splicing. (1991) (143)
D3 receptor test in vitro predicts decreased cocaine self‐administration in rats (1997) (139)
Opiate receptors on mesolimbic dopaminergic neurons (1978) (135)
Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum (1976) (134)
Minireview: histamine receptors in brain. (1979) (132)
Involvement of the direct striatonigral pathway in levodopa‐induced sensitization in 6‐hydroxydopamine‐lesioned rats (2000) (131)
Effects of histamine H3-receptor ligands on various biochemical indices of histaminergic neuron activity in rat brain. (1989) (131)
[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors. (1994) (131)
Participation of both ‘enkephalinase’ and aminopeptidase activities in the metabolism of endogenous enkephalins (1983) (130)
Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor. (1983) (129)
Selective Expression of Dopamine D3 Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain (1997) (127)
Ontogeny of dopaminergic D-2 receptors in the rat nervous system: Characterization and detailed autoradiographic mapping with [125I]iodosulpride (1989) (127)
Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence (1978) (126)
Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area (1976) (125)
Detailed mapping of the histamine H2 receptor and its gene transcripts in guinea-pig brain (1997) (125)
Meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians. (1998) (124)
Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line. (1994) (124)
Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial (2017) (123)
Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. (1989) (119)
Distribution of enkephalinase (membrane metalloendopeptidase, E.C. 3.4.24.11) in rat organs. Detection using a monoclonal antibody. (1988) (118)
Guinea Pig Histamine H1 Receptor. II. Stable Expression in Chinese Hamster Ovary Cells Reveals the Interaction with Three Major Signal Transduction Pathways (1994) (117)
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition. (1981) (117)
Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms (2000) (117)
Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes. (1990) (116)
Metabolism of enkephalins and the inactivating neuropeptidase concept (1983) (114)
Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan. (1989) (111)
Localization and function of the D3 dopamine receptor. (1992) (110)
Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes. (1985) (109)
Histamine synthesis in the developing rat brain: Evidence for a multiple compartmentation (1975) (109)
Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions (1997) (108)
Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees. (1993) (107)
Regional distribution of a high-affinity enkephalin-degrading peptidase (‘enkephalinase’) and effects of lesions suggest localization in the vicinity of opiate receptors in brain (1979) (107)
Histamine neuronal pathways and their functions (1987) (107)
Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence (1998) (105)
Functional relationship between mast cells and C-sensitive nerve fibres evidenced by histamine H3-receptor modulation in rat lung and spleen. (1994) (105)
Lack of association between schizophrenia and alleles in the dopamine D3 receptor gene (1993) (104)
Enkephalinase activity in rat peripheral organs. (1981) (104)
Dopamine-related genes and their relationships to monoamine metabolites in CSF (1996) (98)
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. (2001) (98)
Cloning and tissue expression of a rat histamine H2-receptor gene. (1991) (97)
Characterization of aminopeptidases responsible for inactivating endogenous (Met5)enkephalin in brain slices using peptidase inhibitors and anti-aminopeptidase M antibodies. (1986) (97)
Properties of "enkephalinase" from rat kidney: comparison of dipeptidyl-carboxypeptidase and endopeptidase activities. (1982) (96)
Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus. (1978) (95)
Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. (2007) (94)
Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT). (1996) (94)
The Histamine receptor (1991) (94)
Localisation and pharmacological characterisation of D-2 dopamine receptors in rat cerebral neocortex and cerebellum using [125I]iodosulpride. (1985) (93)
In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs. (1979) (92)
N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands (2003) (91)
Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation. (1992) (90)
[Gene cloning of human dopaminergic D3 receptor and identification of its chromosome]. (1990) (90)
Localization of opiate receptors in substantia nigra evidence by lesion studies (1979) (90)
Ontogenesis of enkephalinergic systems in rat brain: post-natal changes in enkephalin levels, receptors and degrading enzyme activities. (1980) (90)
3H-Glycogen hydrolysis elicited by histamine in mouse brain slices: selective involvement of H1 receptors. (1980) (89)
Histidine decar☐ylase and histamine in discrete nuclei of rat hypothalamus and the evidence for mast-cells in the median eminence (1976) (89)
Ciproxifan, a Histamine H3-Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat (2002) (89)
Histamine H3 receptor binding sites in rat brain membranes: modulations by guanine nucleotides and divalent cations. (1990) (87)
A rat G protein‐coupled receptor selectively expressed in myelin‐forming cells (1998) (87)
3H-apomorphine labels both dopamine postsynaptic receptors and autoreceptors (1980) (87)
Cloning of OL1, a putative olfactory receptor and its expression in the developing rat heart. (1995) (85)
Turnover of histamine in rat brain and its decrease under barbiturate anesthesia. (1974) (85)
Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides. (1980) (83)
Dopamine D3 receptor gene variants and substance abuse in schizophrenia (1998) (83)
Pharmacology of enkephalinase inhibitors (1985) (82)
Synthesis and release of histamine studied on slices from rat hypothalamus. (1975) (81)
Development of Novel 1,2,3,4‐Tetrahydroisoquinoline Derivatives and Closely Related Compounds as Potent and Selective Dopamine D3 Receptor Ligands (2004) (81)
Glycogenolysis induced by serotonin in brain: identification of a new class of receptor (1982) (81)
Disruption of nicotine conditioning by dopamine D3 receptor ligands (2003) (81)
Major localization of aminopeptidase M in rat brain microvessels (1987) (81)
No association between schizophrenia and homozygosity at the D3 dopamine receptor gene. (1993) (80)
Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. (2012) (79)
Synthesis of Potent Non‐imidazole Histamine H3‐Receptor Antagonists (1998) (78)
Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia. (1996) (78)
Is 'enkephalinase' identical with 'angiotensin-converting enzymes'? (1979) (77)
Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug. (1997) (77)
Modulation in the sensitivity of noradrenergic receptors in the CNS studied by the responsiveness of the cyclic AMP system (1976) (77)
The dopamine D3 receptor mediates locomotor hyperactivity induced by NMDA receptor blockade (2003) (77)
The rat H3 receptor: gene organization and multiple isoforms. (2001) (76)
In vivo binding of 3H-pimozide in mouse striatum: effects of dopamine agonists and antagonists. (1977) (75)
Properties and roles of the three subclasses of histamine receptors in brain. (1986) (75)
Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor. (1995) (74)
Detailed immunoautoradiographic mapping of enkephalinase (EC 3.4.24.11) in rat central nervous system: Comparison with enkephalins and substance P (1989) (74)
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. (1992) (73)
Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure (1990) (72)
Three classes of histamine receptors in brain (1986) (71)
Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model (2013) (70)
Histamine receptors in the brain. (1985) (68)
Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. (1991) (66)
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide. (1993) (65)
The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. (1995) (63)
'Enkephalinase' is distinct from brain 'angiotensin-converting enzyme'. (1979) (62)
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: No role in the genetic predisposition to bipolar affective disorder (1993) (62)
Turnover of cerebral histamine in a stressful situation (1977) (61)
Lack of Association between Anorexia Nervosa and D3 Dopamine Receptor Gene (1998) (61)
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. (2002) (61)
Two Intracellular Signaling Pathways for the Dopamine D3 Receptor: Opposite and Synergistic Interactions with Cyclic AMP (1997) (61)
Expression analysis of the histamine H3 receptor in developing rat tissues (2001) (61)
Dissociated effects of inhibitors of enkephalin-metabolising peptidases or naloxone on various nociceptive responses. (1986) (59)
Chapter Nine – Histamine Receptors in the Brain and Their Possible Functions (1982) (58)
Inhibitory potency of various peptides on enkephalinase activity from mouse striatum. (1979) (58)
Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease (2004) (58)
Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor. (2002) (57)
Endorphins and endorphin receptors in striatum: relationships with dopaminergic neurons. (1978) (57)
Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade. (1999) (57)
Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin (2010) (57)
Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms (2004) (57)
Regulation of Histamine Release and Synthesis in the Brain by Muscarinic Receptors (1989) (56)
Synergism between histamine H1- and H2-receptors in the cAMP response in guinea pig brain slices: effects of phorbol esters and calcium. (1988) (55)
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. (1996) (55)
[125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor. (1996) (55)
Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis. (2000) (55)
Assessment of the role of “enkephalinase” in cholecystokinin inactivation (1985) (54)
Stereoselectivity of the histamine H3-presynaptic autoreceptor. (1985) (54)
Histamine synthesizing afferents within the amygdaloid complex and bed nucleus of the stria terminalis of the rat (1977) (53)
Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations (1980) (53)
Enkephalin degradation in mouse brain studied by a new H.P.L.C. method: further evidence for the involvement of carboxydipeptidase. (1979) (53)
No evidence of linkage between schizophrenia and D3 dopamine receptor gene locus in Icelandic pedigrees (1993) (53)
Stimulation of cerebral histamine H2 receptors by clonidine (1976) (52)
Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril. (1994) (51)
Modulation of Histamine Release and Synthesis in the Brain Mediated by α2‐Adrenoceptors (1989) (51)
Neurochemical evidence for histamine acting as a transmitter in mammalian brain. (1976) (50)
Vasopeptidase inhibitors: an emerging class of cardiovascular drugs. (2001) (50)
The histamine H3 receptor and its ligands. (2001) (50)
Rapid development of hypersensitivity of striatal dopamine receptors induced by alpha-methylparatyrosine and its prevention by protein synthesis inhibitors. (1977) (49)
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. (1987) (48)
Different antagonist binding properties of human and rat histamine H3 receptors. (2001) (48)
Sensitive Radioimmunoassays for Histamine and tele‐Methylhistamine in the Brain (1989) (47)
Histaminergic mechanisms in brain. (1977) (47)
BRAIN HISTIDINE DECARBOXYLASE ACTIVITY IN PARKINSON'S DISEASE (1983) (47)
N‐methyl‐d‐aspartate receptor antagonists enhance histamine neuron activity in rodent brain (2006) (47)
Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity. (1996) (46)
Molecular and Functional Diversity of Histamine Receptor Subtypes (1995) (46)
Simultaneous presence of histamine-N-methyltransferase and catechol-O-methyltransferase in neuronal and glial cells in culture (1975) (46)
Regulation of histamine release in rat hypothalamus and hippocampus by presynaptic galanin receptors (1991) (46)
The dopamine D3 receptor and drug addiction (2001) (45)
Characterization of the high-affinity binding sites of [3H]histamine in rat brain. (1980) (45)
Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women: The EVA study (2004) (45)
Characterization of 3H-domperidone binding on striatal dopamine receptors. (1978) (43)
Increased in vivo binding of 3H-pimozide in mouse striatum following repeated administration of haloperidol. (1978) (43)
Chromosomal mapping and organization of the human histamine H3 receptor gene (2001) (43)
Hypersensitivity to histamine in the guinea-pig brain: Microiontophoretic and biochemical studies (1978) (43)
Subcellular distribution of enkephalin-dipeptidyl carboxypeptidase (enkephalinase) in rat brain (1981) (42)
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists. (2002) (42)
Enkephalinase from rat kidney. Purification, characterization, and study of substrate specificity. (1984) (42)
Changes in dopamine receptors in mouse striatum following morphine treatments. (1979) (42)
Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway. (2004) (42)
Role of dopamine D3 receptors in thermoregulation: a reappraisal (2000) (41)
Chromosomal localization of the human D3 dopamine receptor gene (1991) (41)
Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells (1995) (41)
Co-localization of histamine with GABA but not with galanin in the human tuberomamillary nucleus (2002) (41)
Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug. (2000) (41)
A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists. (1996) (40)
Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. (2002) (40)
Highly Potent Fluorescence‐Tagged Nonimidazole Histamine H3 Receptor Ligands (2007) (40)
The dopamine D3 receptor and schizophrenia: pharmacological, anatomical and genetic approaches (1995) (39)
Histamine receptors in brain as targets for tricyclic antidepressants (1981) (39)
Lack of association between schizophrenia and alleles of the dopamine D1, D2, D3 and D4 receptor loci1 (1993) (39)
Decreased responsiveness to low doses of apomorphine after dopamine agonists and the possible involvement of hyposensitivity of dopamine ‘autoreceptors’ (1977) (39)
A serine peptidase responsible for the inactivation of endogenous cholecystokinin in brain. (1988) (39)
Histamine and histidine decarboxylase in brain stem nuclei: distribution and decrease after lesions (1978) (39)
Histamine H2 receptor gene variants: lack of association with schizophrenia (2000) (38)
Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization. (2011) (38)
Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans. (2000) (38)
Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1 (2003) (38)
Labeling of histamine H1-receptors in the brain of the living mouse (1980) (37)
3H-Domperidone: A selective ligand for dopamine receptors (1979) (37)
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists. (2006) (37)
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. (1992) (37)
Specific desensitization of histamine H1 receptor-mediated [3H]glycogen hydrolysis in brain slices. (1981) (36)
Relationship between occupation of cerebral H1-receptors and sedative properties of antihistamines. Assessment in the case of terfenadine. (1982) (36)
Ciproxifan, a histamine H3‐receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum (2003) (36)
Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial (2020) (36)
Modulation of Histamine Release in the Rat Brain by K‐Opioid Receptors (1990) (35)
Selective participation of both "enkephalinase" and aminopeptidase activities in the metabolism of endogenous enkephalins. (1982) (35)
[125I]Iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain. (1986) (35)
Subsensitivity of noradrenaline-stimulated cyclic AMP accumulation in brain slices of d-amphetamine-treated mice (1975) (35)
Carboxypeptidase A Isoforms Produced by Distinct Genes or Alternative Splicing in Brain and Other Extrapancreatic Tissues (*) (1995) (34)
Antihypertensive activity of sinorphan (1990) (34)
Comparison of dipeptidyl carboxypeptidase and endopeptidase activities in the three enkephalin-hydrolysing metallopeptidases: "angiotensin-converting enzyme", thermolysin and "enkephalinase". (1985) (34)
Metabolism and functions of histamine in the brain. (1979) (34)
Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. (2000) (34)
Characterization of a tyrosine sulfotransferase in rat brain using cholecystokinin derivatives as acceptors. (1985) (34)
Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects. (1987) (33)
Decreased histamine synthesis in the rat brain by hypnotics and anaesthetics (1973) (33)
ARNT2, a transcription factor for brain neuron survival? (1999) (33)
Steady-state level and turnover rate of the tripeptide Tyr-Gly-Gly as indexes of striatal enkephalin release in vivo and their reduction during pentobarbital anesthesia. (1986) (33)
High affinity binding of 3H-histamine in rat brain. (1978) (33)
Synthesis, absolute configuration, stereoselectivity, and receptor selectivity of (alpha R, beta S)-alpha,beta-dimethylhistamine, a novel high potent histamine H3 receptor agonist. (1992) (32)
Monoclonal antibody against l-histidine decarboxylase for localization of histaminergic cells (1985) (32)
Effect of sinorphan, an enkephalinase inhibitor, on plasma atrial natriuretic factor and sodium urinary excretion in cirrhotic patients with ascites. (1991) (32)
Histamine receptors in the brain: characterization by binding studies and biochemical effects. (1980) (32)
Two splice variants of the hypoxia‐inducible factor HIF‐1α as potential dimerization partners of ARNT2 in neurons (2000) (32)
Metabolism of methylhistamine formed through a new pathway: decarboxylation of L-3-methylhistidine. (1973) (31)
Responses of anterior pituitary hormones and hypothalamic histamine to blockade of histamine synthesis and to selective activation or inactivation of presynaptic histamine H3 receptors in stressed rats. (1993) (31)
Increased synthesis and release of 3H-histamine in rat brain by reserpine. (1973) (31)
Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor. (2003) (31)
New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H3 receptors. (1995) (30)
Neurochemical Investigations into the Human Area Postrema (1986) (30)
Rat cerebral mast cells undergo phenotypic changes during development. (1996) (30)
Effects of kainic acid on histaminergic systems in guinea pig hippocampus (1978) (29)
Enkephalinase (EC 3.4.24.11) is highly localized to a striatonigral pathway in rat brain (1987) (29)
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin. (1984) (29)
Binding of 3H-Leu-enkephalin in rat striatum: partial inhibition by morphine or naloxone. (1977) (29)
The D3 receptor and its relevance in psychiatry (1995) (29)
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. (2003) (29)
Design of potent non-thiourea H3-receptor histamine antagonists. (1995) (29)
Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe. (1988) (29)
Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds. (2003) (29)
Localization of the histamine H2 receptor and gene transcripts in rat stomach: back to parietal cells. (1994) (28)
Biochemical neuroanatomy of the human substantia nigra (pars compacta) in normal and Parkinsonian subjects. (1982) (28)
Decrease in histamine content and decarboxylase activities in an isolated area of the cerebral cortex of the cat (1975) (28)
Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study. (1996) (28)
Fluorinated non-imidazole histamine H3 receptor antagonists. (2009) (27)
The preferential dopamine D3 receptor ligand, (+)-UH232, is a partial agonist. (1995) (27)
Electron microscopic localization of immunoreactive enkephalinase (EC 3.4.24.11) in the neostriatum of the rat (1990) (26)
Characterisation of two probes for the localisation of enkephalinase in rat brain: [3H]thiorphan and a 125I-labeled monoclonal antibody. (1987) (26)
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity. (1999) (26)
Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinities. (2006) (26)
Protection by serine peptidase inhibitors of endogenous cholecystokinin released from brain slices (1989) (26)
Tolerance to hypokinesia elicited by dopamine agonists in mice: hyposensitization of autoreceptors? (1977) (26)
Three classes of dopamine receptor (D-2, D-3, D-4) identified by binding studies with 3H-apomorphine and 3H-domperidone (2004) (26)
Opiate receptors on catecholaminergic neurones in brain (1979) (26)
Modulation of pentagastrin-induced histamine release by histamine H3 receptors in the dog. (1996) (25)
N-ethylmaleimide-induced changes in agonist affinity for histamine H1-receptors in the guinea pig brain. (1985) (25)
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors. (1985) (25)
Obstructive Sleep Apnea patients adhering to Continuous positive Airway Pressure: A randomized trial. (2020) (25)
Localization, regulation, and role of the dopamine D3 receptor are distinct from those of the D2 receptor. Discussion (1995) (25)
Edg‐2 in myelin‐forming cells: Isoforms, genomic mapping, and exclusion in Charcot‐Marie‐Tooth disease (1999) (25)
Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers. (2017) (24)
Modulation of Histamine Synthesis and Release in Brain via Presynaptic Autoreceptors and Heteroreceptors (1990) (24)
Optically active benzamides as predictive tools for mapping the dopamine D2 receptor. (1990) (24)
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. (2000) (23)
[3H]glycogenolysis in brain slices mediated by β-adrenoceptors: Comparison of physiological response and [3H]dihydroalprenolol binding parameters (1988) (23)
Development of FUB 181, a Selective Histamine H3‐Receptor Antagonist of High Oral in Vivo Potency with 4‐(?gv‐(Arylalkyloxy)alkyl)‐1H‐imidazole Structure (1998) (23)
Effects of mesencephalic and hypothalamic lesions on histamine levels in rat brain. (1973) (23)
Fluorescent enkephalin derivatives with biological activity. (1978) (23)
Location of enkephalinase and functional effects of [Leu5]enkephalin and inhibition of enkephalinase in the feline main pancreatic and bile duct sphincters. (1992) (23)
Differential recognition of "enkephalinase" and angiotensin-converting enzyme by new carboxyalkyl inhibitors. (1982) (22)
Localization of enkephalinase mRNA in rat brain by in situ hybridization: Comparison with immunohistochemical localization of the protein (1989) (22)
The use of [3H](-)-DO 710 as selective dopaminergic ligand for binding and autoradiographic studies. (1985) (22)
Inactivation of atrial natriuretic factor in mice in vivo: crucial role of enkephalinase (EC 3.4.24.11). (1990) (22)
Histamine formation in rat stomach: study of regulation mechanisms. (1969) (22)
First metal-containing histamine H3 receptor ligands. (2010) (21)
Conformation and biological activities of hexapeptides related to enkephalins: respective roles of the ammonium and hydroxyl groups of tyrosine. (1979) (21)
A gradual score to evaluate the climbing behaviour elicited by apomorphine in mice (1978) (21)
Detection of the tripeptide Tyr‐Gly‐Gly, a putative enkephalin metabolite in brain, using a sensitive radioimmunoassay (1985) (21)
Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy (2019) (21)
Adaptive changes of neurotransmitter receptor mechanisms in the central nervous system. (1983) (21)
Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels. (1990) (21)
Comparison of acetorphan with clonidine for opiate withdrawal symptoms. (1991) (20)
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J) (1989) (20)
Photoaffinity Labeling and Electrophoretic Identification of the H1‐Receptor: Comparison of Several Brain Regions and Animal Species (1989) (20)
Antipsychotics with inverse agonist activity at the dopamine D3 receptor (2005) (20)
Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain (1999) (20)
Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain (2002) (20)
Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction. (1995) (20)
Enkephalin metabolism in brain and its inhibition (1982) (19)
Diuretic and natriuretic responses in rats treated with enkephalinase inhibitors. (1990) (19)
Purification of membrane-bound aminopeptidase from rat brain: Identification of aminopeptidase M (1985) (19)
Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction. (1999) (19)
Dopamine D3 receptor gene expression in the shell of nucleus accumbens is increased by chronic antidepressant treatment (2000) (19)
L-Histidine Decarboxylase (1986) (19)
4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity. (1998) (19)
Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. (1999) (19)
Imetit and N-methyl derivatives. The transition from potent agonist to antagonist at histamine H3 receptors.1 (1992) (19)
Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis (2005) (19)
Novel Dopamine Receptor Subtypes as Targets for Antipsychotic Drugs (1995) (19)
Acidic elements in histamine H(3) receptor antagonists. (2010) (18)
Pitolisant for Daytime Sleepiness in Obstructive Sleep Apnea Patients Refusing CPAP: A Randomized Trial. (2020) (18)
A third histamine receptor subtype: Characterisation, localisation and functions of the H3-receptor (1990) (18)
Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. (2002) (18)
Homology Model Versus X-ray Structure in Receptor-based Drug Design: A Retrospective Analysis with the Dopamine D3 Receptor. (2011) (18)
Interaction between mianserin, an antidepressant drug, and central H1- and H2-histamine-receptors: In vitro and in vivo studies and radioreceptor assay (1983) (18)
A Novel Potential Metallopeptidase Derived from the Enkephalinase Gene by Alternative Splicing (1990) (18)
Presence of dopamine D-2 receptors in human tumoral cell lines. (1989) (17)
Acylated and alkylated histamine derivatives as new histamine H3-receptor antagonists (1994) (17)
Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity. (2011) (17)
Role of a serine endopeptidase in the hydrolysis of exogenous cholecystokinin by brain slices (1989) (17)
Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists. (2004) (17)
Sulfation and Desulfation of Cerebral Cholecystokinin (1985) (17)
Photoaffinity labeling of D-2 dopamine binding subunits from rat striatum, anterior pituitary and olfactory bulb with a new probe, [3H]azidosulpride. (1985) (17)
Selection of dopamine antagonists discriminating various behavioral responses and radioligand binding sites (1984) (17)
Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists. (2002) (17)
Degradation of atrial natriuretic factor in mouse blood in vitro and in vivo: Role of enkephalinase (EC 3.4.24.11) (1990) (17)
The endogenous tripeptide Tyr-Gly-Gly as a possible metabolite of opioid peptides in rat brain: Identification, regional distribution, effects of lesions and formation in depolarized slices (1986) (17)
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. (2000) (17)
Disappearance of energy-transfer as a tool for fluorimetric study of the degradation of enkephalins by aminopeptidase activity from mouse brain. (1979) (16)
Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands (2001) (16)
Purification and substrate specificity of rat kidney "enkephalinase". (1982) (16)
Evidence that histamine H3 receptors are involved in the control of gastric acid secretion in the conscious cat (1991) (16)
Exploratory Phase II Trial to Evaluate the Safety and the Antiepileptic Effect of Pitolisant (BF2.649) in Refractory Partial Seizures, Given as Adjunctive Treatment During 3 Months (2016) (16)
3H-domperidone binding sites differ in rat striatum and pituitary (1984) (16)
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors. (2000) (16)
Properties variations and possible synaptic functions of "enkephalinase": a newly characterised dipeptidyl carboxypeptidase. (1980) (16)
Identification , characterization , and localization of the dopamine D 3 receptor in rat brain using 7-[ 3 H ] hydroxy-NN-din-propyl-2-aminotetralin ( guanine nucleotide-binding regulatory protein-coupled receptor / antipsychotics / islands of Calleja / cerebellum / nucleus accumbens ) (16)
Azines and Diazines as Potential Histamine H3‐Receptor Antagonists (1995) (16)
Circadian rhythm of histamine in the pineal gland. (1974) (16)
Evaluation of enkephalinase inhibition in the living mouse, using [3H]acetorphan as a probe. (1988) (15)
The histamine H3-receptor: pharmacology, roles and clinical implications studied with agonists. (1991) (15)
Application of genomics to drug design: the example of the histamine H3 receptor (2001) (15)
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. (2005) (15)
Histaminergic Systems in Brain (1979) (15)
Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. (2008) (15)
Endogenous histamine induces c‐fos expression within paraventricular and supraoptic nuclei (1995) (15)
Diphenylmethyl ethers: synthesis and histamine H3-receptor antagonist in vitro and in vivo activity (1996) (15)
Unsymmetrically substituted guanidines as potent histamine H3-receptor antagonists (1994) (15)
The Third Histamine Receptor (1989) (15)
General construction pattern of histamine H3-receptor antagonists: change of a paradigm. (1998) (14)
Effects of cycloheximide and/or morphine on enkephalin levels in mouse striatum. (1978) (14)
Histamine in the Brain: Importance of Transmethylation Processes and Their Regulation (1974) (14)
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice (1990) (14)
Pharmacological characterization of 3H-LSD binding sites in mouse brain in vivo. (1979) (14)
Apparent identity of cerebral tyrosylsulfotransferase activities using either a cholecystokinin derivative or an acidic amino acid polymer as substrate (1987) (14)
Modulation of histamine release and synthesis in the brain mediated by alpha 2-adrenoceptors. (1989) (14)
Azole derivatives as histamine H3 receptor antagonists, part I: thiazol-2-yl ethers. (2010) (13)
Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists. (2013) (13)
Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro‐arrhythmia Assay initiative studies (2017) (13)
Phencyclidine blocks histamine H3-receptors in rat brain. (1988) (13)
Immunoautoradiographic localisation of enkephalinase (EC 3.4.24.11) in rat gastrointestinal tract (1991) (13)
Pharmacokinetics of pitolisant in children and adolescents with narcolepsy. (2019) (13)
Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids (1984) (13)
Multiple dopamine receptors: the D3 receptor and actions of substances of abuse. (1994) (13)
Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H1 receptors (1987) (13)
Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP (13)
"Enkephalinase", a newly characterised dipeptidyl carboxypeptidase: properties and possible role in enkephalinergic transmission. (1980) (12)
THE DOPAMINE D3 RECEPTOR AS A KEY TARGET FOR ANTIPSYCHOTICS (1992) (12)
Enkephalin metabolism and its inhibition. (1985) (12)
Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides. (2005) (12)
Occupancy of dopamine D2 and D3 receptors by a novel D3 partial agonist BP1.4979: a [11C]-(+)-PHNO PET study in humans (2018) (12)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N‐Methyltransferase: ω‐Piperidinoalkanamine Derivatives (2004) (12)
HISTAMINE AS A TRANSMITTER IN MAMMALIAN BRAIN (1976) (12)
Novel Histamine H3‐Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure‐Activity Relationships (1996) (12)
Endorphins in several regions of rat brain: large differences between radioimmunoassay and radioreceptor assay. (1977) (12)
Functional models for the dopamine D3 receptor. (1996) (12)
Heterocyclic congeners of PD 128,907 with a partially hydrogenated benzomorpholine moiety as potential dopamine D3-receptor ligands (1999) (12)
Pyrazoles as Potential Histamine H3‐Receptor Antagonists (1995) (12)
Molecular cloning of rat mast cell protease 1 and development of specific probes for its gene transcript. (1994) (11)
Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET (2020) (11)
Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H_2-receptor (1990) (11)
Synthesis of pyridyl isosteres of thioperamide as H3-receptor histamine antagonists (1991) (11)
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands. (2003) (11)
Thiorphan-induced natriuresis in volume-expanded rats: roles of endogenous atrial natriuretic factor and kinins. (1991) (11)
Peptidases involved in the inactivation of exogenous and endogenous enkephalins. (1983) (11)
Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-α-methylhistamine (2001) (10)
Dopaminergic Behavioral Responses and Classes of Binding Sites Distinguished by Discriminant Benzamide Derivatives (1986) (10)
Metabolism of enkephalins and its inhibition (1984) (10)
Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. (2005) (10)
Interaction of mianserin, amitriptyline and haloperidol with guinea pig cerebral histamine H2 receptors studied with [125I]iodoaminopotentidine. (1991) (10)
errata Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist (1999) (10)
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. (2017) (10)
Highly potent and selective ligands for a new class H3 of histamine receptor. (1988) (9)
Heterogeneity and regulation of central dopamine receptor subtypes studied by cDNA cloning methodology (1992) (9)
4-(ω-(Alkyloxy)alkyl)-1H-imidazole Derivatives as Histamine H3 Receptor Antagonists/Agonists (2004) (9)
Effects of discriminant and non-discriminant dopamine antagonists on in vivo accumulation of 3H-N-propyl-norapomorphine in mouse striatum and tuberculum olfactorium (1985) (9)
N‐(4‐(4‐(2‐Halogenophenyl)piperazin‐1‐yl)butyl) Substituted Cinnamoyl Amide Derivatives as Dopamine D2 and D3 Receptor Ligands (2007) (9)
Efficacy of pitolisant in patients with high burden of narcolepsy symptoms: pooled analysis of short-term, placebo-controlled studies. (2021) (9)
Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan, an enkephalinase inhibitor. (1989) (9)
Dopamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (9)
Unexpected potentiation by discriminant benzamide derivatives of stereotyped behaviours elicited by dopamine agonists in mice (1985) (9)
Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA) (1989) (9)
Synthesis, X‐Ray Crystallography, and Pharmacokinetics of Novel Azomethine Prodrugs of (R)‐α‐Methylhistamine: Highly Potent and Selective Histamine H3 Receptor Agonists. (1996) (9)
Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. (2011) (9)
New potent histamine H3-receptor antagonists of the amide type (1995) (9)
Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine: from alkylaryl to substituted diaryl derivatives. (1996) (9)
Properties and Localization of the Sulfate‐Activating System in Rat Brain (1987) (9)
Subclassification of histamine receports, H3-receptor subtypes? Localization of H3 receptors in the brain (1998) (8)
Highly Potent and Selective Ligands for a New Class H3 of Histamine Receptor (1988) (8)
The D3 Dopamine Receptor Gene as a Candidate Gene for Genetic Linkage Studies (1992) (8)
Potent inhibition of cerebral aminopeptidases by carbaphethiol, a parenterally active compound (1988) (8)
Dopaminergic binding sites in rat striatal slices and the action of guanyl nucleotides (1984) (8)
ONTOGENESIS OF ENKEPHALINERGIC SYSTEMS IN RAT BRAIN (1980) (8)
Prodynorphin mRNA expression in the rat dentate gyrus after cerebral ischemia (1996) (8)
Changes in levels of the tripeptide Tyr-Gly-Gly as an index of enkephalin release in the spinal cord: Effects of noxious stimuli and parenterally-active peptidase inhibitors (1989) (7)
Labelling and exploration of the active site of enkephalinase (EC 3.4.24.11) in kidney membranes with [3H]thiorphan as ligand. (1988) (7)
Histamine-related enzymes and histamine receptors in isolated brain capillaries (1979) (7)
Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. (2000) (7)
Rat climbing behavior elicited by stimulation of cerebral dopamine receptors (1984) (7)
A radioimmunoassay for the tripeptide Gly-Trp-Met, a major metabolite of endogenous cholecystokinin in brain (1996) (7)
Title Brain histamine and schizophrenia : potential therapeutic applications of H 3-receptor inverse agonists studied with BF 2 . 649 (2007) (7)
Improving selectivity of dopamine D3 receptor ligands. (2016) (7)
Clinical trials with H3-receptor inverse agonists: What they tell us about the role of histamine in the human brain (2016) (7)
Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. (2004) (7)
Inhibitors and dipeptide substrates for a microsomal tyrosylsulfotransferase from rat brain. (1986) (7)
Behavioral and neurochemical profiles of discriminant benzamide derivatives. Comment (1987) (7)
Development of FUB 181, a Selective Histamine H3-Receptor Antagonist of High Oral in vivo Potency with 4-(ω-(Arylalkyloxy)alkyl)-1H-imidazole Structure. (1998) (6)
Novel and highly potent histamine H3 receptor ligands. Part 3: an alcohol function to improve the pharmacokinetic profile. (2013) (6)
Pharmacological studies on the role of histamine in thermoregulation (1973) (6)
Radiosynthesis and biodistribution of two potential antagonists of cerebral histamine H3 receptors for PET studies: [18F]FUB 272 and [11C]UCL 1829 (1998) (6)
Phenotypic and quantitative changes in mast cells after syngeneic unilateral lung transplantation in the rat. (1996) (6)
[Function and therapeutic potential of the dopamine D3 receptor]. (1998) (6)
Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. (2010) (6)
Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists. (2016) (6)
NEW ASYMMETRIC SYNTHESIS OF DEXECADOTRIL AND ECADOTRIL STARTING FROM A SINGLE PRECURSOR (2001) (6)
Two D2 dopamine receptor isoforms generated via alternative mRNA splicing: regional distribution and effects of haloperidol treatments (1990) (6)
[Potential interest in powerful and specific ligands for the histamine H3 receptor]. (1988) (6)
Immunohistochemical and subcellular studies of aminopeptidase M localization in rat brain: microvessels and synaptic membranes. (1986) (5)
New Potent Azomethine Prodrugs of the Histamine H3‐Receptor Agonist (R)‐α‐Methylhistamine Containing a Heteroarylphenyl Partial Structure (1996) (5)
Adaptative changes in two indices of enkephalin neuron activity in mouse striatum following GABAergic stimulation. (1990) (5)
The Dopamine D3 Receptor and Its Implication in Neuropsychiatry Disorders and Their Treatments (2002) (5)
Autoradiographic localisation of3H-apomorphine binding sites in rat brain (1985) (5)
Evidence for a specific decarboxylase involved in histamine synthesis in an ascending pathway in rat brain (1974) (5)
The effect of atropine on histidine decarboxylase of the stomach of the rat (1969) (5)
HIV-related diarrhea : Efficacy of acetorphan in a randomized controlled trial (1995) (5)
Novel chiral H3-receptor agonists. (1991) (5)
Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands. (2010) (5)
Synthesis of Potent Non‐Imidazole Histamine H3‐Receptor Antagonists. (1999) (5)
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency]. (1991) (5)
Function and regulation of the D3 dopamine receptor (1993) (5)
Discovery of Pitolisant, the First Marketed Histamine H3‐Receptor Inverse Agonist/Antagonist for Treating Narcolepsy* (2018) (4)
Reversible and irreversible labelling of H1- and H2 -receptors using novel [125I] probes. (1991) (4)
OPIATE RECEPTORS LOCALIZED PRESYNAPTICALLY ON DOPAMINERGIC AND NORADRENERGIC NEURONS IN BRAIN: RELEVANCE TO TOLERANCE AND DEPENDENCE TO OPIOIDS (1979) (4)
Gastric Antisecretory Effects of Compound BP 2-94 (A Histamine H3-Receptor Agonist Prodrug) (1999) (4)
Schwartz et al. reply (1986) (4)
[Development of hystaminergic systems in the newborn rat brain]. (1970) (4)
Autoreceptors and Heteroreceptors Evidenced by Histamine H3 Receptor Ligands (1991) (4)
Histaminergic Transmission in the Brain (2011) (4)
Pitolisant, a wake‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol (2021) (4)
Two distinct classes of dopamine receptor mediating actions of antipsychotics: binding and behavioral studies. (1983) (4)
Pharmacological studies of histamine as a central neurotransmitter (1976) (4)
Neuropharmacology of Histamine in Brain (2007) (3)
Histamine Receptors and Actions in Mammalian Brain (1983) (3)
Search for novel leads for histamine H3-receptor antagonists: oxygen-containing derivatives. (1997) (3)
Novel Histamine H3-Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure-Activity Relationships. (1997) (3)
Time to Onset of Response to Pitolisant for the Treatment of Excessive Daytime Sleepiness and Cataplexy in Patients With Narcolepsy: An Analysis of Randomized, Placebo-Controlled Trials (2021) (3)
Modifications of brain HA metabolism induced by antihistamines (1973) (3)
Production d'anticorps monoclonaux anti-L-histidine décarboxylase (1983) (3)
0615 Pitolisant in Combination With Other Medications for the Management of Narcolepsy (2019) (3)
Studies on the inhibition of histamine methylation in mice (1973) (3)
Role of brain-derived neurotrophic factor in the control of D3 receptor expression (1999) (3)
Constitutive activity of the recombinant and native histamine H3 receptor (2003) (3)
Enkephalin dipeptidyl carboxypeptidase ("enkephalinase"): assay, properties, and distribution in human brain and exploration of the active site. (1982) (3)
Formation and Utilization of the Active Sulfate Donor [35S]3′‐Phosphoadenosine 5′‐Phosphosulfate in Brain Slices: Effects of Depolarizing Agents (1987) (3)
Novel Agents Affecting Enkephalinergic And Histaminergic Transmissions In Brain (1987) (3)
[Acetorphan, a potent enkephalinase inhibitor, does not modify orocecal and colonic transit times in healthy subjects]. (1989) (3)
Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives† (1995) (3)
Synthesis of Pyridyl Isosteres of Thioperamide as H3-Receptor Histamine Antagonists. (1992) (3)
The histamine H3 receptor: pharmacology and potential therapeutic applications. (1993) (3)
Design of an Affinity Matrix for Purification of the Histamine H1 Receptor from Guinea Pig Cerebellum (1992) (3)
RELATIONSHIP BETWEEN LIPOPHILICITY AND BRAIN UPTAKE OF AZOMETHINE PRODRUGSOF A HISTAMINE H3-RECEPTOR AGONIST (1996) (3)
Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity. (2000) (3)
Structure-activity studies with histamine H3-receptor ligands. (1995) (3)
3H-Dopamine binding sites differ in rat striatum and pituitary. (1984) (3)
Pitolisant in combination with other medications for the management of narcolepsy (2019) (2)
[Action of acetorphan, an enkephalinase inhibitor, in acute diarrhea]. (1992) (2)
Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (2)
Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease (2004) (2)
Polymorphism of the dopamine D3 receptor gene associated with opioid dependence (1996) (2)
Autoradiographic localisation of 3H-apomorphine binding sites in rat brain. (1985) (2)
Fasidotril: The First Dual Inhibitor of Neprilysin and ACE (2006) (2)
Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [1251]iodinated probes (2)
Fasting or dexamethasone treatment reduce protease content in rat lung mast cells and modulation of histamine synthesis by H3 receptors (1994) (2)
Histidine decarboxylase (HD) in rat brain: Studies on subcellular localization (1973) (2)
Histamine H3 receptors in the brain: potent and selective ligands. (1989) (2)
3H-DOMPERIDONE AND 3H-PIMOZIDE : MORE SPECIFIC LIGANDS FOR DOPAMINE RECEPTORS STUDIED IN VITRO AND IN VIVO (1979) (2)
Enkephalinase inhibitors: potential therapeutic applications in gastroenterology and the cardiovascular field (1990) (2)
Characterization of a serine peptidase responsible for the inactivation of endogenous cholecystokinin in human brain (1995) (2)
[Dopaminergic receptors, multiple targets for neuroleptics]. (1992) (2)
FURTHER CHARACTERISATION AND KINETICS OF APPEARANCE OF HYDROLYSIS PRODUCTS OF MET-ENKEPHALIN (1980) (2)
3H-(-)DO 710 discriminates guanine nucleotide sensitive and insensitive dopamine binding sites (1985) (1)
Biochemical studies on histaminergic systems in mammalian brains (1981) (1)
Anticataplectic efficacy of wakix® (pitolisant), the first potent and highly selective histamine h3-receptor antagonist/inverse agonist in clinics (2017) (1)
Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands (2009) (1)
Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly. (1986) (1)
Substituted N-phenylcarbamates as histamine H3 receptor antagonists with improved in vivo potency. (2000) (1)
Increase in striatal enkephalin release following stimulation of the D2-dopamine receptor (1990) (1)
Heterocyclic Congeners of PD 128,907 with a Partially Hydrogenated Benzomorpholine Moiety as Potential Dopamine D3-Receptor Ligands. (2010) (1)
Potent Partial Agonists for the Histamine H3 Receptor Lacking a Nitrogen Atom in the Side Chain (2002) (1)
The third histamine receptor. Highly potent and selective ligands. (1989) (1)
Synthesis and Histamine H3‐Receptor Agonist Activity of Mono‐ and Dialkyl‐Substituted Histamine Derivatives. (1995) (1)
P84 novel potent histamine H3-receptor antagonists (1994) (1)
[Opioid peptides: metabolism and receptors]. (1987) (1)
An alternative route for biosynthesis of methylhistamine: In vitro and in vivo formation through decarboxylation ofl-3-methylhistidine (1972) (1)
The Dopamine D3 Receptor in the Pathophysiology and Treatment of Neuropsychiatric Disorders (2003) (1)
Histamine H3 receptors : novel ligands and responses (1992) (1)
Synthesis and release of3H-histamine in slices from rat brain (1974) (1)
0612 Evaluation of Abuse Potential of the Narcolepsy Medication Pitolisant (2019) (1)
852 – CHARACTERIZATION OF HISTAMINE RECEPTORS MEDIATING CYCLIC AMP ACCUMULATION IN HIPPOCAMPAL SLICES (1978) (1)
Application of genomics to drug design: the example of the histamine H 3 (2001) (1)
PROPERTIES OF ENKEPHALINASE FROM MOUSE AND HUMAN BRAIN (1981) (1)
Corrigendum to “Fluorinated non-imidazole histamine H3 receptor antagonists” [Bioorg. Med. Chem. Lett. 19 (2009) 2172] (2009) (1)
Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine. (2001) (1)
98-1 Implication of genes coding for dopamine receptors (D2 and D3) in alcohol dependence (1997) (1)
The third dopamine receptor (D3): new perspectives in therapeutics. (1993) (1)
[Rapid and prolonged facilitation of stereotyped motor behavior (verticalization) induced by apomorphine in mice previously submitted to stimulation of dopaminergic receptors]. (1976) (1)
Topographical distribution of histamine and histidine decarboxylase activity in hypothalamus and brain stem modifications by lesions (1977) (1)
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists. (2004) (1)
Decreased turnover of histamine in the brain of restrained mice (1975) (1)
Endogenous Enkephalins, Depression and Antidepressants (1988) (1)
Search for novel leads for histamine H3-receptor antagonists: amine derivatives. (1997) (1)
Binding of [125I]atrial natriuretic factor to mouse lung membranes in vivo: characterization and effects of peptidase inhibitors. (1992) (1)
Multiple Dopamine Receptors: Implications for Schizophrenia (1995) (1)
Diphenylmethyl Ethers: Synthesis and Histamine H3-Receptor Antagonist in vitro and in vivo Activity. (1996) (1)
Evaluation of abuse potential of the narcolepsy medication pitolisant (2019) (1)
A novel [125I]iodinated carboxypeptidase A substrate detects a metallopeptidase activity distinct from carboxypeptidase A in brain (1996) (1)
[Regional distribution of histamine in the rat brain]. (1969) (1)
0623 Long-Term Evaluation of Safety and Efficacy of Pitolisant In Narcolepsy: Harmony III Study (2018) (1)
[Inhibition of the evoked liberation of (Met5)enkephalin from slices of globus pallidus in the presence of thiorphan and bestatin]. (1983) (1)
P.5.011 Genes coding for dopamine receptors (D2 & D3) and alcohol dependence (1997) (0)
Naphthamide derivatives, processes for their preparation as well as the implementation according to the therapeutic range (1992) (0)
The endogenous tripeptide Tyr-Gly-Gly as an extracellular metabolite of enkephalins in rat brain: origin and metabolism. (1986) (0)
Partial agonists for the histamine H3 receptor with high in vivo activity (2001) (0)
Roles of the D3 receptor and brain-derived neurotrophic factor in behavioural sensitisation to psychomotor stimulants (2002) (0)
Derivatives of 1-azacycloalkyl-N-3-phenoxy which may be used for the preparation of psychotropic drugs (2006) (0)
Polymorphic Forms fasidotril, their preparation processes and pharmaceutical compositions containing them (2002) (0)
Modulation of pentagastrin-induced histamine release by histamine H3 receptors in the anaesthetized dog (1995) (0)
Clozapine and other atypical neuroleptics enhance histamine neuron activity: Evidence for serotonin implication (1998) (0)
ASSOCIATION OF D3 RECEPTOR GENE POLYMORPHISM WITH SCHIZOPHRENIA (1992) (0)
P85 highly potent and selective histamine H3-receptor antagonists (1994) (0)
"Atriopeptidase" (EC 3.4.24.11) inhibition and protection of atrial natriuretic factor. (1994) (0)
New imidazole derivatives, their preparation and their therapeutic applications. (1993) (0)
14 HISTAMINE (2001) (0)
L-histidine Decarboxylase a Marker of Histaminergic Neurons (2007) (0)
Long-term evaluation of safety and efficacy of pitolisant in narcolepsy: harmony 3 study (2019) (0)
Non-imidazolalkylaminer as histamine H 3 receptor and the therapeutic uses thereof (1999) (0)
Arylpiperazinderivate and their use as for the dopamine D3 receptor selective ligand (2005) (0)
[INFLUENCE OF DINITROPHENOL ON THE FIXATION AND INACTIVATION OF HISTAMINE BY RAT KIDNEY SLICES]. (1964) (0)
A process for the asymmetric synthesis of the S-acylated derivatives of 2-mercaptomethyl-3-phenylpropanoic acid and its use t (1997) (0)
Formulating dry powder comprising racedotril. (2001) (0)
[Gastric histidine decarboxylase and experimental ulcers in rats]. (1966) (0)
Synthesis process alpha-substituted acrylic acids and its application. (1996) (0)
Tetracyclic 1,4-oxazinderivater, process for their preparation and to pharmaceutical preparations which contain dis (1995) (0)
New metalloprotease ii nep membrane and its use for screening inhibitors useful in therapy (1998) (0)
[Selective stimulation of histamine H3 autoreceptors]. (1987) (0)
875 – CLOMIPRAMINE-INDUCED HYPOSENSITIVITY OF SEROTONIN RECEPTORS AS A POSSIBLE MECHANISM FOR ANTIDEPRESSANT ACTION, BEHAVIOURAL STUDY (1978) (0)
Derive histamine, its preparation and its application in therapeutic (1988) (0)
Third Histamine Receptor: From Discovery to Clinics, Long-Lasting Love Story at INSERM and Bioprojet (2008) (0)
[Uptake and inactivation of histamine by the rat kidney]. (1967) (0)
(Imidazolyl-4) piperidines, their preparation and their application in therapeutic (1985) (0)
Dopamine D3 receptor agents in schizophrenia (1999) (0)
New compounds derived amino acid enantiomers, their preparation process and their therapeutic applications. (1988) (0)
SC10 Design of non-thiourea H3-receptor histamine antagonists (1994) (0)
Neuronal and non-neuronal histamine in rat brain: tentative localization of the nerve cell bodies (1977) (0)
[Facilitation of a stereotyped motor behavior (climbing behavior) by previous stimulation of dopaminergic receptors: hyposensitivity of autoreceptors?]. (1977) (0)
2048 – ALTERATIONS OF SPONTANEOUS AND APOMORPHINE-INDUCED CLIMBING BEHAVIOURS BY MODIFICATIONS OF SOME NEUROTRANSMISSIONS (1978) (0)
Efficacy and safety of pitolisant in patients with narcolepsy: a review of clinical trials (2019) (0)
New tetracyclic piperidine and 1,4-oxazine (1995) (0)
0624 Anticataplectic Efficacy of Pitolisant, the First Potent and Highly Selective Histamine H3-Receptor Antagonist/Inverse Agonist (2018) (0)
Prodrug developments on histamine H3-receptors agonists (1996) (0)
Peptidase inhibitors tripeptidyl. (1998) (0)
THE ROLE OF CRAVING IN FAILURE OF DRUG DETOXIFICATION (1996) (0)
New imidazole derivatives, their preparation and therapeutic uses (1993) (0)
New derivatives of 2-naphtamides and therapeutic applications (1995) (0)
Frontiers in histamine research : a tribute to Heinz Schild : based on an international symposium held at Jouy-en-Josas (near Paris), France, 25-27 July 1984 (1985) (0)
S.27.05 Nicotine and dopamine D3 receptor: Implications in drug addiction and Parkinson's disease (2003) (0)
Use of histamine derivatives for producing drugs, new histamine derivatives and drugs. (1992) (0)
Tetracyclic derivatives of the 1,4-oxazine, their preparation process and pharmaceutical compositions containing them. (1995) (0)
[Binding sites for 3H-Leu-enkephalin in rat straitum]. (1977) (0)
New racecadotril administration form (2007) (0)
[Uptake and inactivation of histamine by the rat kidney: characteristics of the transport system]. (1965) (0)
The use of histamine derivatives for fremtilling of drugs, novel histamine derivatives and pharmaceutical (1992) (0)
New compounds derived enantiomers of amino acids, their process for the preparation and therapeutic applications (1987) (0)
SHIRLEY A. KNAPP, MITCHELL D. GREEN, THOMAS R. TEPHLY, AND JEFFREY BARON. Immunohistochemical Demonstration oflsozyme- and Strain-Specific Differences in the Intralobular Localizations and Distributions of UDP-Glucuronyltransferases (1988) (0)
S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands (2003) (0)
Process for the synthesis of derivatives N- (mercaptoacyl) -amino acids from acrylic acids alpha-substituted (2000) (0)
Novel optical isomer derived from amino acid, its production and application thereof to medicine (1988) (0)
[Endogenous histamine and thermoregulation]. (1972) (0)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N-Methyltransferase: ω-Piperidinoalkanamine Derivatives. (2005) (0)
P83 CNS delivery of a potent histamine H3-agonist via prodrugs (1994) (0)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N-Methyltransferase: w-Piperidinoalkanamine (2004) (0)
860 – LOCALIZATION AND MODULATION OF HISTAMINE RECEPTORS IN GUINEA-PIG BRAIN (1978) (0)
505 Efficacy of Pitolisant in the Treatment of Cataplexy in Adults With Narcolepsy (2021) (0)
Augmentation in hypothalamic histamine induced by diencephalic lesions in rats (1973) (0)
Novel histamine h3 receptor antagonist and / or agonist imidazole derivatives, their preparation and their therapeutic applications (1995) (0)
NEW PIPERIDINYLMONOCARBOXYLSYRER AS S1P1 receptor agonists (2012) (0)
Novel 2-naphthamides and their therapeutic applications as receptor agonists d3. (1996) (0)
1-N-azacycloalkyl-3-phenoxypropane derivatives useful for the preparation of psychotropic medications (2006) (0)
New imidazole derivatives, their production and therapeutic use (1993) (0)
P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists (2004) (0)
Characterization of histamine H1-receptor binding peptides in guinea pig brain using ('25I)iodoazidophenpyramine, an irreversible specific photoaffinity probe (photoaffinity labels/mepyramine derivative) (2016) (0)
859 – CHARACTERIZATION OF THE HISTAMINERGIC SYSTEM IN HUMAN BRAIN (1978) (0)
[Endogenous histamine and experimental gastric ulcers in the rat]. (1967) (0)
Benzhydryl ethers prossessing combined histamine H3/H1-receptor antagonist activity (1996) (0)
Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands. (2001) (0)
[Neuropeptidases responsible for the inactivation of enkephalins and the pharmacology of their inhibitors]. (1986) (0)
New naphthamide derivatives and their therapeutic use as D3 receptor agonists (1996) (0)
amino-2 ethanethiol derivatives, their preparation and their application in therapeutic (1986) (0)
Racecadotril containing dry powder formulation (2001) (0)
Arylpiperazine derivatives and their use as selective ligands of D3 receptor dopamineric (2005) (0)
Studies on the biosynthesis and localization of histamine in the developing rat brain (1974) (0)
1443 – OPIATE RECEPTORS ON CEREBRAL NORADRENERGIC NEURONS AND DEVELOPMENT OF HYPERSENSITIVITY TO NORADRENALINE AFTER CHRONIC MORPHINE (1978) (0)
Sensoryexperiencemodifies theshort-termdynamicsof neocortical synapses (0)
[In vivo binding of tritiated agents in mouse brain]. (1977) (0)
Therapeutic use as histamine H3 receptor ligands of alkyl amines which do not contain imidazoles (1999) (0)
Design of potent non-imidazole histamine H3-receptor antagonists (2003) (0)
United States Patent 19 Plaquevent et al . 54 AMINO ACID DERIVATIVES (2017) (0)
[Production of anti-L-histidine decarboxylase monoclonal antibodies]. (1983) (0)
Histamine-induced responses in mammalian brain slices: characterization of H1 and H2 receptors. (1983) (0)
Effect of long-term therapy with fasidotril , a mixed inhibitor of neprilysin and angiotensin-converting enzyme ( ACE ) , on survival of rats after 1 myocardial infarction (1999) (0)
S.21.01 Function and regulation of the expression of the D3 receptor: Therapeutic implications (1997) (0)
Naphthamide, methods of preparation and their therapeutic application (1992) (0)
A process for the asymmetric synthesis of S-acylated derivatives of 2-mercaptomethyl-3-phenylpropionic acid and derivatives amino-use thereof for the synthesis of N-mercaptoacyl (1997) (0)
Expression of a cloned rat histamine H 2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation ( second messengers / phospholipase A 2 / [ 125 I ] iodoaminopotentidine / Chinese hamster ovary cells ) (0)
Histamine derivatives containing pharmaceutical composition. (1986) (0)
Törpulverformulering which converts racecadotril (2001) (0)
Histamine receptors in GtoPdb v.2021.3 (2021) (0)
Schwartz and Sokoloff reply: Selective agonists and antagonists are needed to determine a functional role for dopamine D3 receptors (1995) (0)
Polypeptides with dopaminergic receptor, nucleic acids encoding these polypeptides and use of these polypeptides for the detection of active substances on these polypeptides. (1991) (0)
Derived histamine, their preparation and their use in therapy. (1989) (0)
2733 – HISTAMINERGIC SYSTEMS IN BRAIN (1978) (0)
Process for asymmetric synthesis of s-acyl derivatives of 2-mercaptomethyl-3-phenyl propanoic application to the synthesis of derivatives n- (mercaptoacyl) amino acids (1996) (0)
Inhibitors of tripeptidilpeptidasa. (1996) (0)
[Dopamine and enkephalins. Effects of dopaminergic agents on the levels of striatal tyrosyl-glycyl-glycine]. (1989) (0)
Inhibitors of lta4 hydrolase and their therapeutic applications. (1999) (0)
Clonidine, a potent agonist of histamine H2-receptors in guinea-pig brain (1977) (0)
Relationships between cerebrospinal fluid monoamine metabolites and dopamine-related genotypes in healthy volunteers (1995) (0)
Therapeutic use as histamine h3 receptor-ligand of alkylamines containing no imidazole (1999) (0)
Amino acid derivatives, their preparation and use as medicaments (1990) (0)
Physiological Roles of Histamine H3-Receptors (1989) (0)
ANALGESIC EFFECTIVENESS OF INTRATHECAL INHIBITORS OF ENKEPHALINASE AND AMINOPEPTIDASE IN MAN (1987) (0)
The discovery of potent non-imidazole H3-receptor histamine antagonists (2001) (0)
Efficacy and Safety of Pitolisant in Patients With Narcolepsy: A Review of Clinical Trials (P3.6-034) (2019) (0)
New Asymmetric Synthesis of Dexecadotril and Ecadotril Starting from a Single Precursor. (2001) (0)
modafinil association and an antagonist or inverse agonist of the receptor h3 (2006) (0)
New derivatives of imidazole antagonists and / or agonists of the H3 receptor of histamine, their preparation and their therapeutic applications (1995) (0)
Identification et inhibition d'une peptidase responsable de l'inactivation de la cholécystokinine (1996) (0)
858 – HISTAMINERGIC SYSTEMS IN BRAIN (1978) (0)
Amino acid derivatives and their use as enkeltfalinaseinhibitorer (1994) (0)
Pitolisant safety and efficacy in adult narcoleptic patients with or without cataplexy or idiopathic hypersomnia patients in a compassionate use program in france: autorisation temporaire d'utilisation de cohorte (ATUc) (2017) (0)
Novel 2-naphtanamidderivater and therapeutic uses thereof, as agonists of D 3 receptors (1996) (0)
A pharmaceutical composition containing a-methylhistamine (1985) (0)
BDNF-Dependent Behavioral Sensitization in Hemiparkinsonian Rats (2002) (0)
Histamine h3 receptor agonists for therapeutic application, pharmaceutical preparations acting on h3-adrenergic receptor-agonist, un the method of its presentation (1991) (0)
Arylpiperazine derivatives and their use as selective receptor ligands d3 dopamine. (2005) (0)
MOLECULAR BIOLOGY AND PHARMACOLOGY OF HISTAMINE RECEPTOR SUBTYPES (1992) (0)
New derivatives of imidazole, their preparation and their therapeutic applications. (1992) (0)
Long-term evaluation of safety and efficacy of pitolisant (wakix ® ), an histamine H3R antagonist, in narcolepsy (2017) (0)
New derivatives of aryl piperazine (2004) (0)
Correction of dizocilpine-induced behavioral and biochemical abnormalities by dopamine D3 receptor blockade or invalidation in the mouse (2002) (0)
PosterP128 the imidazole ring is an essential moiety of potent histamine H3-receptor antagonists (1994) (0)
N‐(4‐(4‐(2‐Halogenophenyl)piperazin‐1‐yl)butyl) Substituted Cinnamoyl Amide Derivatives as Dopamine D2 and D3 Receptor Ligands. (2007) (0)
LTA 4 hydrolase inhibitors and their therapeutic applications. (1999) (0)
N-alkyl carbamates as potent and selective histamine H3- receptor antagonists (1996) (0)
Polypeptides with human dopaminergic receptor, nucleic acids encoding such polypeptides and use of such polypeptides for screening active substances for such polypeptides. (1991) (0)
new dicarboxylic acid derivatives (2004) (0)
Pitolisant efficacy on cataplexy: a double blind, randomised, placebo controlled trial in patients with narcolepsy (the HARMONY-CTP trial) (2017) (0)
(Imidazolyl-4) piperidines, to their preparation and use as medicaments. (1986) (0)
Aza) cyclohexanes carbonylated as ligands of D3 dopamine receptor (2007) (0)
Opioid Peptides and their Relevance for CNS Mechanisms; Role of “Enkephalinase” (Enkephalin-Dipeptidylcarboxypeptidase) as Synaptic Neuropeptidase (1982) (0)
[Autoradiographic study of the distribution of C14-histamine and its metabolites in rat kidney]. (1966) (0)
[Fixation and inactivation of histamine by rat kidney slices]. (1962) (0)
504 Assessment of the Clinical Benefits of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy (2021) (0)
Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process (1996) (0)
FC22 development of A[125I]labelled histamine H3-receptor antagonist (1994) (0)
5. Histamine receptor expression¶Impact of lipophilicity on the pharmacological properties of histamine H3-receptor antagonists of the cycloalkyl carbamate class (2002) (0)
General Construction Pattern of Histamine H3‐Receptor Antagonists: Change of a Paradigm. (1998) (0)
New psychiatric drug combination and use of an antagonist or inverse agonist of the histamine H3 receptor to prepare a medicine to prevent undesirable effects of psychotropics. (2003) (0)
Design of protease inhibitors from structures of substrate products. The example of butabindide, an inhibitor of the cholecystokinin (CCK-8)-inactivating peptidase (1997) (0)

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