Jean‐claude Henquin
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Biology
Jean‐claude Henquin's Degrees
- PhD Biochemistry Université Paris Cité
- Masters Molecular Biology Université Paris Cité
- Bachelors Biology Université Paris Cité
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(Suggest an Edit or Addition)Jean‐claude Henquin's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Triggering and amplifying pathways of regulation of insulin secretion by glucose. (2000) (1163)
- Pancreatic β‐cell mass in European subjects with type 2 diabetes (2008) (694)
- Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. (1992) (530)
- Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. (2001) (504)
- Regulation of insulin secretion: a matter of phase control and amplitude modulation (2009) (436)
- Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. (1997) (430)
- Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. (2005) (331)
- Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets. (1993) (325)
- Cellular composition of the human diabetic pancreas (1983) (311)
- Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. (1993) (276)
- Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell. (1992) (254)
- Mechanisms of the Stimulation of Insulin Release by Saturated Fatty Acids: A Study of Palmitate Effects in Mouse β-cells (1994) (227)
- D-Glucose inhibits potassium efflux from pancreatic islet cells (1978) (216)
- Nutrient Control of Insulin Secretion in Isolated Normal Human Islets (2006) (208)
- Hierarchy of the β‐cell signals controlling insulin secretion (2003) (202)
- Signals and pools underlying biphasic insulin secretion. (2002) (190)
- Pancreatic alpha cell mass in European subjects with type 2 diabetes (2011) (182)
- Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells. (1982) (176)
- The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells. (2011) (170)
- The role of vanadium in the management of diabetes. (1995) (165)
- Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets. (1998) (164)
- Control mechanisms of the oscillations of insulin secretion in vitro and in vivo. (2002) (155)
- The Changes in Adenine Nucleotides Measured in Glucose-stimulated Rodent Islets Occur in β Cells but Not in α Cells and Are Also Observed in Human Islets* (1998) (155)
- In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells. (2006) (151)
- Diet‐ and diabetes‐induced changes of ob gene expression in rat adipose tissue (1995) (149)
- Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats (2004) (145)
- Long term improvement of glucose homeostasis by vanadate treatment in diabetic rats. (1988) (144)
- Concentration Dependence and Time Course of the Effects of Glucose on Adenine and Guanine Nucleotides in Mouse Pancreatic Islets* (1996) (143)
- Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells (1984) (135)
- Phentolamine and yohimbine inhibit ATP‐sensitive K+ channels in mouse pancreatic β‐cells (1990) (134)
- Uptake and Release of Ca2+ by the Endoplasmic Reticulum Contribute to the Oscillations of the Cytosolic Ca2+ Concentration Triggered by Ca2+ Influx in the Electrically Excitable Pancreatic B-cell* (1999) (129)
- The Elevation of Glutamate Content and the Amplification of Insulin Secretion in Glucose-stimulated Pancreatic Islets Are Not Causally Related* (2002) (127)
- The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas. (1991) (125)
- Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues. (2004) (125)
- Both Triggering and Amplifying Pathways Contribute to Fuel-induced Insulin Secretion in the Absence of Sulfonylurea Receptor-1 in Pancreatic β-Cells* (2004) (119)
- Cell populations in the endocrine pancreas of human neonates and infants (1981) (116)
- Influence of cell number on the characteristics and synchrony of Ca2+ oscillations in clusters of mouse pancreatic islet cells (1999) (114)
- The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism. (1998) (113)
- Marked Improvement of Glucose Homeostasis in Diabetic ob/ob Mice Given Oral Vanadate (1990) (113)
- Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets. (1995) (113)
- Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets. (1975) (111)
- Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats. (1989) (110)
- Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response. (2001) (108)
- Glucose-induced mixed [Ca2+]c oscillations in mouse beta-cells are controlled by the membrane potential and the SERCA3 Ca2+-ATPase of the endoplasmic reticulum. (2006) (106)
- High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic β Cells* (2001) (105)
- Imidazoline antagonists of α2‐adrenoceptors increase insulin release in vitro by inhibiting ATP‐sensitive K+ channels in pancreatic β‐cells (1992) (104)
- The ionic, electrical, and secretory effects of endogenous cyclic adenosine monophosphate in mouse pancreatic B cells: studies with forskolin. (1984) (103)
- Diazoxide and D600 Inhibition of Insulin Release: Distinct Mechanisms Explain the Specificity for Different Stimuli (1982) (102)
- Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. (2004) (101)
- SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. (2002) (100)
- Opposite effects of intracellular Ca2+ and glucose on K+ permeability of pancreatic islet cells (1979) (96)
- Effects of putative activators of K+ channels in mouse pancreatic β‐cells (1989) (96)
- Pronase Effect on Pancreatic Beta Cell Secretion and Morphology (1973) (96)
- Emptying of Intracellular Ca2+ Stores Stimulates Ca2+ Entry in Mouse Pancreatic β‐Cells by Both Direct and Indirect Mechanisms (1997) (93)
- Stable and diffusible pools of nucleotides in pancreatic islet cells. (1996) (92)
- Temporal and Quantitative Correlations Between Insulin Secretion and Stably Elevated or Oscillatory Cytoplasmic Ca2+ in Mouse Pancreatic β-Cells (1998) (92)
- Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets (1995) (90)
- Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx. (1988) (90)
- Effects of amino acids on membrane potential and 86Rb+ fluxes in pancreatic beta-cells. (1981) (89)
- Regulation of insulin release by ionic and electrical events in B cells. (1987) (82)
- The GluCre‐ROSA26EYFP mouse: A new model for easy identification of living pancreatic α‐cells (2007) (81)
- Shortcomings of current models of glucose‐induced insulin secretion (2009) (81)
- Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. (1994) (80)
- A single mechanism for the stimulation of insulin release and 86Rb+ efflux from rat islets by cationic amino acids. (1982) (80)
- ATP-sensitive K+ channels may control glucose-induced electrical activity in pancreatic B-cells. (1988) (78)
- Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle. (2001) (77)
- Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. (2003) (77)
- The muscarinic receptor subtype in mouse pancreatic B‐cells (1988) (76)
- Glucose Stimulates Ca2+ Influx and Insulin Secretion in 2-Week-old β-Cells Lacking ATP-sensitive K+ Channels* (2007) (75)
- Galanin and epinephrine act on distinct receptors to inhibit insulin release by the same mechanisms including an increase in K+ permeability of the B-cell membrane. (1990) (75)
- High incidence of hypoglycaemia in African patients treated with intravenous quinine for severe malaria. (1987) (73)
- Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2. (2009) (72)
- Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells (2009) (68)
- Dynamics of glucose-induced insulin secretion in normal human islets. (2015) (66)
- Tetraethylammonium potentiation of insulin release and inhibition of rubidium efflux in pancreatic islets. (1977) (66)
- Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets. (1988) (66)
- Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype. (1999) (66)
- Metabolic control of potassium permeability in pancreatic islet cells. (1980) (65)
- Potassium dependence of the membrane potential of pancreatic B‐cells (1978) (64)
- Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications (1987) (64)
- Tolbutamide and diazoxide influence insulin secretion by changing the concentration but not the action of cytoplasmic Ca2+ in beta-cells. (1998) (61)
- Developmental and nutritional changes of ob and PPAR gamma 2 gene expression in rat white adipose tissue. (1997) (60)
- The electrogenic sodium—potassium pump of mouse pancreatic B‐cells (1982) (60)
- Mechanisms of the stimulation of insulin release by arginine-vasopressin in normal mouse islets. (1990) (60)
- Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells (2013) (59)
- Cyclic variations of glucose-induced electrical activity in pancreatic B cells (1982) (57)
- Contribution of the endoplasmic reticulum to the glucose-induced [Ca(2+)](c) response in mouse pancreatic islets. (2002) (57)
- Effects of trifluoperazine and pimozide on stimulus-secretion coupling in pancreatic B-cells. Suggestion for a role of calmodulin? (1981) (57)
- The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. (2007) (57)
- Insulin and insulin-like growth factor 1 antagonize the stimulation of ob gene expression by dexamethasone in cultured rat adipose tissue. (1997) (56)
- Cationic Environment and Dynamics of Insulin Secretion: II. Effect of a High Concentration of Potassium (1974) (55)
- Tolbutamide stimulation and inhibition of insulin release: Studies of the underlying ionic mechanisms in isolated rat islets (1980) (55)
- Disorganization of cytoplasmic Ca2+ oscillations and pulsatile insulin secretion in islets from ob/ob mice (2002) (55)
- Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content (1999) (55)
- Congenital hyperinsulinism and mosaic abnormalities of the ploidy (2005) (54)
- Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments. (2010) (54)
- Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate. (1996) (53)
- Tenth Annual Meeting of the European Association for the Study of Diabetes (1974) (53)
- Relative importance of extracellular and intracellular calcium for the two phases of glucose-stimulated insulin release: studies with theophylline. (1978) (53)
- Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets. (1991) (52)
- Oscillations of insulin secretion can be triggered by imposed oscillations of cytoplasmic Ca2+ or metabolism in normal mouse islets. (1999) (52)
- Feedback control of the ATP-sensitive K(+) current by cytosolic Ca(2+) contributes to oscillations of the membrane potential in pancreatic beta-cells. (2002) (51)
- Functional significance of Ca2+ oscillations in pancreatic beta cells. (1998) (51)
- Bicarbonate modulation of glucose-9nduced biphasic insulin release by rat islets. (1976) (51)
- Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets (1994) (51)
- Distinct effects of glucose on the synchronous oscillations of insulin release and cytoplasmic Ca2+ concentration measured simultaneously in single mouse islets. (1995) (50)
- Dibutyryl cyclic AMP triggers Ca2+ influx and Ca2+-dependent electrical activity in pancreatic B cells. (1983) (50)
- The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work? (1992) (50)
- Muscarinic stimulation increases Na+ entry in pancreatic B-cells by a mechanism other than the emptying of intracellular Ca2+ pools. (1996) (49)
- Glucose Regulation of Insulin Secretion Independent of the Opening or Closure of Adenosine Triphosphate-Sensitive K+ Channels in β Cells. (1999) (49)
- In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions. (2011) (49)
- Repercussions of chronic protein-calorie malnutrition on glucose homeostasis in the rat (1987) (48)
- Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion (1999) (48)
- G protein‐dependent inhibition of L‐type Ca2+ currents by acetylcholine in mouse pancreatic B‐cells. (1997) (47)
- Effects of extracellular adenine nucleotides on the electrical, ionic and secretory events in mouse pancreatic β‐cells (1989) (47)
- Glucose Acutely Decreases pH of Secretory Granules in Mouse Pancreatic Islets (2006) (47)
- The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: studies with a phorbol ester. (1987) (46)
- Muscarinic stimulation exerts both stimulatory and inhibitory effects on the concentration of cytoplasmic Ca2+ in the electrically excitable pancreatic B-cell. (1995) (45)
- High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFκB (2005) (44)
- Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells. (1983) (44)
- Modulation of the effect of acetylcholine on insulin release by the membrane potential of B cells. (1987) (44)
- Glucose-Induced Electrical Activity in β-Cells: Feedback Control of ATP-Sensitive K+ Channels by Ca2+ (1990) (43)
- Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide. (2014) (43)
- Glucose modulates Mg2+fluxes in pancreatic islet cells (1983) (43)
- Role of voltage- and Ca2+-dependent K+ channels in the control of glucose-induced electrical activity in pancreatic B-cells (1990) (42)
- Effects of theophylline and dibutyryl cyclic adenosine monophosphate on the membrane potential of mouse pancreatic beta‐cells. (1984) (42)
- The interplay between cyclic AMP and ions in the stimulus-secretion coupling in pancreatic B-cells. (1985) (41)
- Quinine and the stimulus-secretion coupling in pancreatic beta-cells: glucose-like effects on potassium permeability and insulin release. (1982) (41)
- Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP‐sensitive K+ channels (2010) (40)
- Clonidine inhibits ATP‐sensitive K+channels in mouse pancreatic β‐cells (1991) (40)
- Overnight Culture Unmasks Glucose-induced Insulin Secretion in Mouse Islets Lacking ATP-sensitive K+ Channels by Improving the Triggering Ca2+ Signal* (2007) (39)
- The Oscillatory Behavior of Pancreatic Islets from Mice with Mitochondrial Glycerol-3-phosphate Dehydrogenase Knockout* (2000) (39)
- Morphological and functional characteristics of islets neoformed during tissue culture of fetal rat pancreas (1985) (39)
- Disorganization of cytoplasmic Ca(2+) oscillations and pulsatile insulin secretion in islets from ob/ obmice. (2002) (38)
- Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells. (1996) (38)
- Relative contribution of Ca2+‐dependent and Ca2+‐independent mechanisms to the regulation of insulin secretion by glucose (1998) (38)
- G Protein-independent Activation of an Inward Na+Current by Muscarinic Receptors in Mouse Pancreatic β-Cells* (2002) (37)
- Distinct effects of various amino acids on 45Ca2+ fluxes in rat pancreatic islets. (1983) (37)
- Determination of antigen concentration in tissue sections by immunodensitometry. (1989) (37)
- 9-Aminoacridine- and tetraethylammonium-induced reduction of the potassium permeability in pancreatic B-cells. Effects on insulin release and electrical properties. (1979) (37)
- Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate. (1997) (37)
- Immaturity of insulin secretion by pancreatic islets isolated from one human neonate (2017) (36)
- Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets. (2006) (36)
- Cationic environment and dynamics of insulin secretion. I. Effect of low concentrations of sodium. (1974) (36)
- Distinct mechanisms for two amplification systems of insulin release. (1987) (36)
- The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse. (1994) (36)
- Glucose homeostasis in magnesium-deficient rats. (1987) (35)
- The permissive effect of glucose, tolbutamide and high K+ on arginine stimulation of insulin release in isolated mouse islets (1987) (34)
- In Vivo and In Vitro Glucose-Induced Biphasic Insulin Secretion in the Mouse Pattern and Role of Cytoplasmic Ca 2 and Amplification Signals in-Cells (2006) (33)
- Activation of muscarinic receptors increases the concentration of free Na+ in mouse pancreatic B‐cells (1993) (33)
- Distinct effects of acetylcholine and glucose on 45calcium and 86rubidium efflux from mouse pancreatic islets (1984) (33)
- Do Pancreatic β Cells “Taste” Nutrients to Secrete Insulin? (2012) (33)
- Membrane and intracellular effects of adenosine in mouse pancreatic beta-cells. (1989) (33)
- Atypical Ca2+‐induced Ca2+ release from a sarco‐endoplasmic reticulum Ca2+‐ATPase 3‐dependent Ca2+ pool in mouse pancreatic β‐cells (2004) (32)
- Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. (2008) (32)
- Effects of a calcium channel agonist on the electrical, ionic and secretory events in mouse pancreatic B-cells. (1985) (32)
- Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes. (2002) (31)
- Vanadate stimulation of insulin release in normal mouse islets. (1991) (31)
- Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas (2007) (31)
- Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism (1993) (31)
- The insulin-like properties of vanadium: a curiosity or a perspective for the treatment of diabetes? (1991) (31)
- Comparison of the inhibition of insulin release by activation of adenosine and alpha 2-adrenergic receptors in rat beta-cells. (1989) (30)
- Glucose- and concentration-dependence of vasopressin-induced hormone release by mouse pancreatic islets (1992) (30)
- Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP (2003) (30)
- Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls (2017) (29)
- Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP (2004) (29)
- Cationic Environment and Dynamics of Insulin Secretion (1975) (29)
- Cyclic adenosine monophosphate differently affects the response of mouse pancreatic beta‐cells to various amino acids. (1986) (28)
- Comparison of the effects of various vanadium salts on glucose homeostasis in streptozotocin-diabetic rats. (1994) (27)
- Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse. (2012) (27)
- Stimulation of insulin release by benzoic acid derivatives related to the non-sulphonylurea moiety of glibenclamide: structural requirements and cellular mechanisms. (1987) (26)
- Nutrient control of insulin secretion in perifused adult pig islets. (2007) (26)
- Highly potent and stereoselective effects of the benzoic acid derivative AZ‐DF 265 on pancreatic β‐cells (1988) (26)
- Inhibition of protein synthesis sequentially impairs distinct steps of stimulus-secretion coupling in pancreatic beta cells. (2001) (26)
- Sparteine increases insulin release by decreasing the K+ permeability of the B-cell membrane. (1985) (26)
- Pharmacological approach to understanding the control of insulin secretion in human islets (2017) (25)
- A Minimum of Fuel Is Necessary for Tolbutamide to Mimic the Effects of Glucose on Electrical Activity in Pancreatic β-Cells. (1998) (25)
- Extracellular bicarbonate ions and insulin secretion. (1975) (24)
- Influence of organ donor attributes and preparation characteristics on the dynamics of insulin secretion in isolated human islets (2018) (23)
- Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules. (2011) (23)
- Disruption and stabilization of β‐cell actin microfilaments differently influence insulin secretion triggered by intracellular Ca2+ mobilization or store‐operated Ca2+ entry (2012) (23)
- Subplasmalemmal Ca2+ measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion (2010) (23)
- Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening (2014) (23)
- Multisite control of insulin release by glucose. (1994) (22)
- Synchronization and entrainment of cytoplasmic Ca2+ oscillations in cell clusters prepared from single or multiple mouse pancreatic islets. (2004) (22)
- Adenosine triphosphate-sensitive K+ channels may not be the sole regulators of glucose-induced electrical activity in pancreatic B-cells. (1992) (22)
- Effects of acute sodium omission on insulin release, ionic flux and membrane potential in mouse pancreatic B-cells. (1988) (22)
- Protein Deprivation from the Neonatal Period Impairs Lung Development in the Rat (1987) (22)
- Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification by glucose: experiments and modeling. (2019) (22)
- Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets (2002) (21)
- Chloride Modulation of Insulin Release, 86Rb+ Efflux, and 45Ca2+ Fluxes in Rat Islets Stimulated by Various Secretagogues (1983) (21)
- Effects of glibenclamide on pancreatic β-cell proliferation in vivo (1994) (21)
- Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1. (2007) (20)
- The challenge of correctly reporting hormones content and secretion in isolated human islets (2019) (20)
- Adrenaline inhibition of insulin release: role of the repolarization of the B cell membrane (1991) (20)
- cAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments. (2012) (20)
- Insulin secretion: movement at all levels. (2002) (20)
- Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children (2016) (20)
- Influence of low- and high-protein diets on glucose homeostasis in the rat (1988) (20)
- Imidazoline antagonists of alpha 2-adrenoceptors increase insulin release in vitro by inhibiting ATP-sensitive K+ channels in pancreatic beta-cells. (1992) (20)
- Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide (1985) (19)
- Alteration of lung mechanics by protein-calorie malnutrition in weaned rats. (1987) (19)
- High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFκB (2005) (19)
- Adrenaline inhibition of insulin release: role of cyclic AMP (1991) (19)
- Paracrine and autocrine control of insulin secretion in human islets: evidence and pending questions. (2020) (19)
- Somatostatin and the intestinal transport of glucose and other nutrients in the anaesthetised rat. (1982) (19)
- The non-sulfonylurea moiety of gliquidone mimics the effects of the parent molecule on pancreatic B-cells. (1986) (18)
- Do oscillations of insulin secretion occur in the absence of cytoplasmic Ca2+ oscillations in beta-cells? (2002) (18)
- The islet in type 2 diabetes: back to center stage. (2001) (18)
- Pancreatic β‐cell mass or β‐cell function? That is the question! (2008) (17)
- Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk. (2006) (17)
- Glucagon immunoassay using polyethylene glycol to precipitate antibody-bound hormone (1974) (17)
- What ails the β‐cell? (2010) (17)
- Adamantane derivatives: a new class of insulin secretagogues (1987) (17)
- High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NF kappa B (vol 48, pg 496, 2005) (2005) (17)
- The potassium permeability of pancreatic islet cells: mechanisms of control and influence on insulin release. (1980) (17)
- A tale of two cousins: type 1 and type 2 diabetes. (2005) (17)
- Significance of membrane repolarization and cyclic AMP changes in mouse pancreatic B-cells for the inhibition of insulin release by galanin (1994) (17)
- A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic beta-cells. (1998) (16)
- Is there a role for osmotic events in the exocytotic release of insulin? (1986) (16)
- Influence of glucagon on natriuresis and glucose‐induced sodium retention in the fasting obese subject * (1977) (16)
- Abundance of somatostatin cells in the human neonatal pancreas (1980) (16)
- In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist. (1994) (16)
- Effects of putative activators of K+ channels in mouse pancreatic beta-cells. (1989) (16)
- Valinomycin inhibition of insulin release and alteration of the electrical properties of pancreatic B cells. (1978) (15)
- Oral vanadate decreases muscle insulin resistance in obese fa/fa rats (1992) (15)
- Possible involvement of a tyrosine kinase-dependent pathway in the regulation of phosphoinositide metabolism by vanadate in normal mouse islets. (1996) (15)
- Arginine Vasopressin and Oxytocin Effects in Mouse Pancreatic β-cells: Receptors Involved in Stimulation of Insulin Release (1993) (15)
- The effect of pH on 86Rubidium efflux from pancreatic islet cells (1981) (15)
- Acute effects of guar gum on glucose tolerance and intestinal absorption of nutrients in rats. (1982) (15)
- Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo? (2021) (15)
- Tight links between adenine and guanine nucleotide pools in mouse pancreatic islets: a study with mycophenolic acid. (1997) (14)
- Tissue-specific correction of lipogenic enzyme gene expression in diabetic rats given vanadate (1994) (14)
- Cationic environment and dynamics of insulin secretion. IV. Effect of ouabain. (1974) (14)
- A Simple Method Using a Polymethylpenten Chamber for Isolation of Human Pancreatic Islets (2004) (13)
- Effects of glibenclamide on pancreatic beta-cell proliferation in vivo. (1994) (13)
- Sulphonylurea receptor‐1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells (2016) (13)
- The imidazoline SL 84.0418 shows stereoselectivity in blocking alpha 2-adrenoceptors but not ATP-sensitive K+ channels in pancreatic B-cells. (1994) (13)
- Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells. (1999) (13)
- Long in the shade, glucagon re‐occupies centre court (2011) (12)
- Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro (2015) (12)
- Improvement of mild hypoinsulinaemic diabetes in the rat by low non-toxic doses of vanadate. (1994) (12)
- Amplification of insulin secretion by acetylcholine or phorbol ester is independent of β-cell microfilaments and distinct from metabolic amplification (2013) (12)
- Chlorpromazine in malignant insulinoma. (1972) (12)
- Misunderstandings and controversies about the insulin-secreting properties of antidiabetic sulfonylureas. (2017) (12)
- Epinephrine modifications of insulin release and of 86Rb+ or 45Ca2+ fluxes in rat islets. (1983) (12)
- Nutrient insulin secretagogues decrease 45Ca2+ efflux from islet cells by a mechanism other than the inhibition of the Na+‐Ca2+ countertransport (1985) (11)
- Effects of stimulation of adenylate cyclase and protein kinase-C on cultured fetal rat B-cells. (1989) (11)
- Intestinal absorption of sorbitol and effects of its acute administration on glucose homeostasis in normal rats (1985) (11)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla. (2007) (11)
- A simple method using a polymethylpenten chamber for isolation of human pancreatic islets. (2005) (10)
- Magnesium uptake by pancreatic islet cells is modulated by stimulators and inhibitors of the B-cell function. (1986) (10)
- The influence of vanadate on insulin counter-regulatory hormones in obese fa/fa rats. (1991) (10)
- The effects of cesium chloride on insulin release, ionic fluxes and membrane potential in pancreatic B-cells. (1985) (9)
- Forskolin suppresses the slow cyclic variations of glucose-induced electrical activity in pancreatic B cells. (1984) (9)
- Ketoisocaproic acid and leucine increase cytoplasmic pH in mouse pancreatic B cells: role of cytoplasmic Ca2+ and pH-regulating exchangers. (1996) (9)
- Inhibition of Protein Synthesis Sequentially Impairs Distinct Steps of Stimulus-secretion Coupling in Pancreatic β Cells* * This work was supported by the Interuniversity Poles of Attraction Program (P4/21), Belgian State Prime Minister's Office, Federal Office for Scientific, Technical, and Cultura (2001) (8)
- No evidence for a role of reverse Na(+)-Ca2+ exchange in insulin release from mouse pancreatic islets. (1996) (8)
- Glucose-induced electrical activity in beta-cells. Feedback control of ATP-sensitive K+ channels by Ca2+? [corrected]. (1990) (7)
- Glucose modulation of spike activity independently from changes in slow waves of membrane potential in mouse B-cells (1988) (7)
- Non-additivity of adrenaline and galanin effects on 86Rb efflux and membrane potential in mouse B-cells suggests sharing of common targets. (1993) (7)
- Potential role of the early response gene c-myc in beta-cell adaptation to changes in glucose concentration. (2001) (7)
- Cold-induced insulin release in vitro: Evidence for exocytosis (1978) (6)
- Signal transduction: regulation of insulin secretion by changes in Ca2+ concentration and action in pancreatic B-cells (1999) (6)
- Cationic environment and dynamics of insulin secretion III. Effect of the absence of potassium (1974) (6)
- Effects of chloride deficiency on the pancreatic B-cell response to acetylcholine. (1991) (5)
- Glucose homeostasis in rats treated acutely and chronically with quinine. (1986) (5)
- Enzyme‐Induced Modifications of Beta Cell Function (1974) (5)
- Role of the decrease in ionized calcium in the inhibition of insulin release by chloride-free solutions. (1986) (5)
- The influence of temperature on the effects of acetylcholine and adrenaline on the membrane potential and 86Rb efflux in mouse pancreatic B‐cells (1991) (5)
- Specificity of divalent cation requirement for insulin release (2004) (5)
- Editorial: Novel Factors in the Regulation of β-Cell Function (2004) (5)
- Comparison of the inhibition of insulin release by activation of adenosine and x2-adrenergic receptors in rat -cells (2005) (5)
- Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues (1979) (5)
- [Cellular mechanisms of the control of insulin secretion]. (1990) (4)
- Clonidine inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells. (1991) (4)
- Thyrotropin-releasing hormone and insulin release: in vitro studies with islets of normal and dysthyroid mice. (1985) (4)
- Regulation of insulin production: in search of therapeutic targets. Proceedings of the 3rd Servier-IGIS Symposium. St Jean Cap Ferrrat, France, 21-24 March 2002. (2002) (4)
- Potassium ions and insulin release. (1976) (4)
- The influence of sodium omission on alpha 2-adrenergic inhibition of insulin release by mouse islets. (1990) (4)
- Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells (1987) (3)
- Mechanisms of tolbutamide-stimulation of pancreatic B cells — A reply (1980) (3)
- Non-glucose modulators of insulin secretion in healthy humans: (dis)similarities between islet and in vivo studies. (2021) (3)
- Absence of effect of culture duration on glucose-activated alterations in intracellular calcium-concentration in mouse pancreatic-islets - Response (1995) (3)
- Enzyme‐Induced Modifications of Beta Cell Function (1974) (3)
- Enkephalins and Endorphins (1981) (3)
- Somatostatin and the secretion of growth hormone induced by exogenous cyclic 3':5'-adenosine monophosphate in man. (1976) (3)
- Epinephrine Inhibition of Insulin Release - Role of the Na-k Pump and K Permeability of B-cells (1981) (2)
- Of mighty mice and diabetic men: animal models of islet dysfunction (2007) (2)
- Cellular mechanisms of insulin secretion. (2004) (2)
- Erratum: High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFκB (Diabetologia (2005) 48 (496-505) DOI: org/10.1007/s00125-004-1664-4) (2005) (2)
- Evaluation of the Effects of Somatostatin On Intestinal-absorption of Nutrients in Rats (1980) (2)
- Muscarinic Effects of Choline in Mouse Pancreatic B-cells (1987) (2)
- Epinephrine Modifications of Insulin Release and of Rb-86(+) Or Ca-45(2+) Fluxes in Rat Islets (1983) (2)
- Glucose homeostasis in rats acutely and chronically treated with chloroquine. (1984) (2)
- Does Protein Kinase-c Link Glucose-metabolism To B-cell Membrane Depolarization (1989) (2)
- The Functional-significance of Ca-i(2+) Oscillations in Pancreatic B-cells (1994) (2)
- Ionic, Electrical, and Secretory Effects of Inhibitors of Arachidonic Acid Metabolism in Mouse Pancreatic β-Cells (1992) (2)
- Pharmacological control of 86Rb efflux from mouse pancreatic islets. (1986) (2)
- The sodium pump of mouse pancreatic beta-cells: electrogenic properties and activation by intracellular sodium. (1984) (2)
- β‐Cell research – A decade of rapid growth (2009) (2)
- Characterization of the Insulinotropic and Ionic Effects of Cationic Amino-acids (1981) (2)
- Why Is Acetylcholine a Potentiator and Not An Initiator of Insulin Release (1986) (2)
- Ionic and metabolic messengers in the control of insulin secretion. (1997) (2)
- Insulin secretion in response to high extracellular calcium is not a pathognomonic feature of insulinoma cells. (2017) (1)
- Oral Vanadium Improves Glucose-homeostasis in Insulin-resistant Rats (1989) (1)
- A role of granular pH in insulin secretion (2005) (1)
- Synchronization and entrainment of cytoplasmic Ca2+ oscillations in cell clusters prepared from single mouse islets (2002) (1)
- RESEARCH PAPER Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking (2010) (1)
- Glucose-induced Cytosolic pH Changes in β-Cells and Insulin Secretion Are Not Causally Related (2007) (1)
- Vanadium Markedly Improves Glucose-homeostasis in Streptozotocin-diabetic Rats (1988) (1)
- The influence of extracellular calcium and sodium on calcium efflux from rat pancreatic islets [proceedings]. (1979) (1)
- [Biophysical aspects of control of insulin secretion]. (1994) (1)
- Oral Selenium Improves Glucose-homeostasis of Insulin-deficient Diabetic Rats (1994) (1)
- [Triggering and Amplifying Signals in the Control of Insulin-secretion By Glucose] (1995) (1)
- Cyclic-amp and a Phorbol Ester Amplify Tolbutamide-induced Insulin Release By Distinct Mechanisms (1986) (1)
- Mechanisms of Magnesium Efflux From Islet Cells - Analogies With and Differences From Calcium Efflux (1984) (1)
- B cell adrenoceptors and sulphonylurea-induced insulin release in mouse islets (1990) (1)
- Impact of treatment on islet function in type 2 diabetes. (2004) (1)
- Insulinoma Localization by Glucagon-Like Peptide-1 Receptor Imaging After 18 Years of Hypoglycemia (2015) (1)
- Do A1-purinoreceptors Play a Role in the Control of B-cell Function in the Mouse (1988) (1)
- The antioxidants N-acetyl-L-cystein and manganese(III)tetrakis (4-benzoic acid)porphyrin prevent in rat cultured (2006) (0)
- Mechanisms of the Control of Insulin Release By Glucose in Absence of Changes in B-cell Membrane-potential (1992) (0)
- Regulation of Mg Efflux in the Islets of Langerhans of the Rat (1984) (0)
- Does Inhibition of Insulin Release By Adrenaline Involve An Increase in K+ Permeability (pk) of the B-cell Membrane (1989) (0)
- Distinct effects of glucose and other modulators of K-ATP(+) channels on [Ca (2+)](c) in single mouse alpha-cells (2005) (0)
- Effects of Insulin Secretagogues On B-cell Ph in Intact Mouse Islets (1994) (0)
- Correlation Between Glucose Stimulation of Insulin-secretion and the Gtp/gdp Ratio in Mouse Islets (1995) (0)
- Reappraisal of the Role of Cyclic-amp in Stimulus-secretion Coupling in Mouse B-cells (1983) (0)
- Effects of Protein-kinase-c Activation On Beta-cell Responses To Vasopressin and Acetylcholine (1993) (0)
- [Ca]c response in mouse pancreatic islets (2001) (0)
- The Influence of a Tyrosine Kinase Inhibitor On Pancreatic B-cell Function (1993) (0)
- Abstracts of the Summer Meeting 6 June 1996, Louvain-en-Woluwé, Belgium (1996) (0)
- A New Class of Pharmacological Insulin Secretagogues (1986) (0)
- Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg (1990) (0)
- Unmasking of Large Changes in Adenine-nucleotides in Glucose-stimulated Mouse Islets (1994) (0)
- Does Somatostatin Influence the Intestinal-absorption of Carbohydrates and Amino-acids in the Rat (1980) (0)
- Alterations of cytoplasmic Ca2+ regulation in mouse islets unresponsive to GLP-1 (1998) (0)
- Toward a systems biology of insulin secretion and type 2 diabetes (2006) (0)
- Editorial: Toward a Systems Biology of Insulin Secretion and Type 2 Diabetes (2006) (0)
- Response from the authors (2009) (0)
- Beta cell specificity of the effects of glucose on adenine nucleotide (1998) (0)
- [Use of Vanadium in the Treatment of Diabetes - Experimental-data and Clinical-applications] (1992) (0)
- Phosphoinositide (pi) Metabolism and Tyrosine Kinases (tk) in Pancreatic-islets (1995) (0)
- Modulation of the Glucose-induced Electrical-activity in Single Beta-cells of the Mouse Pancreas By Endogenous Cyclic-amp (1984) (0)
- Activation of an inward Na plus current by muscarinic receptors in mouse pancreatic cells (2002) (0)
- Complex Effects of Acetylcholine On Cytoplasmic Ca2+ and Na+ Concentrations in Mouse B-cells (1992) (0)
- How Does Activation of Protein-kinase-c Amplify the B-cell Response To Glucose (1986) (0)
- The Receptors and Mechanisms Involved in the Effects of Vasopressin and Oxytocin in Pancreatic B-cells (1992) (0)
- Does Chloride-sensitive Potassium-ion Permeability of the B-cell Membrane in the Rat Play a Role in Stimulus-secretion Coupling (1982) (0)
- Regulation of biphasic and pulsatile insulin secretion (2009) (0)
- Ca2+-dependent activation of K-ATP channels may explain membrane potential oscillations in glucose-stimulated pancreatic B-cells (2002) (0)
- [Role of vanadium in the treatment of diabetes mellitus. Experimental data and clinical applications]. (1992) (0)
- No Evidence for An Alternative Mechanism of Stimulation of Insulin-secretion By Sulfonylureas (1995) (0)
- Do sulfonylureas and diazoxide influence insulin secretion by modulating the action of Ca2+ in pancreatic beta cells? (1998) (0)
- [Cellular Mechanisms for Controlling Insulin-secretion] (1990) (0)
- [Effect of Leucin and Potassium Permeability and Electric-activity of Pancreatic B-cells] (1980) (0)
- [Is the Na/ca Exchange Inhibited By Glucose in Endocrine Pancreatic-cells] (1985) (0)
- Novel factors in the regulation of beta-cell function. (2004) (0)
- Role of Calcium and Ph-regulating Exchangers On Glucose-induced Changes in B-cell Ph (1994) (0)
- Amino-acids of Various Types Produce Distinct Changes in Calcium Efflux From Rat Islets (1982) (0)
- Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function (2004) (0)
- Mechanisms of Stimulation of Insulin Release By Fatty-acids (1993) (0)
- The Influence of Culture Duration On B-cell Cytoplasmic Ca2+ and Insulin Release (1992) (0)
- [ATP-dependent potassium channels and insulin secretion: essential but not sufficient role]. (2000) (0)
- Do We Really Know How Hypoglycemic Sulfonylureas Stimulate B-cells (1988) (0)
- Physiological relevance of a Ca2+-independent pathway of regulation of insulin secretion by glucose (1998) (0)
- [Role of ion movements and changes in membrane potential in beta cells for the control of insulin secretion]. (1986) (0)
- Influence of Chronic Glucose Indigestion of Glucidic Homeostasis of the Rat (1986) (0)
- isletsinduced by arginine and tolbutamide in mouse Dual mechanism of the potentiation by glucose of insulin (2016) (0)
- Much ado about mycophenolic acid (1997) (0)
- A Paradoxical Effect of Glucose On Insulin Release (1988) (0)
- Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls (2017) (0)
- [Repercussions of a Protein-caloric Deficiency On the Pulmonary Development of the Rat] (1986) (0)
- Pharmacological Characterization of K-channels in Pancreatic Beta-cells (1984) (0)
- Oral Treatment With Molybdate Decreases Insulin-resistance in Ob/ob Mice (1995) (0)
- A Dual Role of Atp in the Control of Insulin Release (1993) (0)
- [Glucose can control cytosolic concentration of Ca2+and the secretion of insulin in beta cells without KATP canals by deficiency in subunit Kir6.2] (2008) (0)
- Formation and Functional-characteristics of Islets Obtained By Tissue-culture of Fetal-rat Pancreas (1984) (0)
- Section 4: Oscillations in -Cells Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo (2002) (0)
- Comparison of the Effects of Adenosine and Adrenaline in Rat B-cells (1988) (0)
- Growth hormone secretion in Addison's disease. (1978) (0)
- Effect of calcium antagonist, cobalt, upon immunoreactive insulin (IRI) secretion from isolated rat islets (1974) (0)
- Role of the Energy-state of B-cells in the Control of Insulin Release (1994) (0)
- Activation of Distinct Receptors Affects Insulin Release By Similar Mechanisms (1989) (0)
- Effects of Genistein, a Tyrosine-kinase Inhibitor, On Pancreatic B-cell Function (1994) (0)
- [Morphologic and Functional-study On Langerhans Islets Obtained From Pancreas Culture From a Rat Fetus] (1984) (0)
- Interactions Between Intracellular H+ and Ca2+ Ions in Nutrient-stimulated Pancreatic-islets (1995) (0)
- Effects of Glucose On B-cell Ph in Intact Islets (1993) (0)
- Characteristics of the oscillations of cytoplasmic Ca2+ in pancreatic beta cells (1998) (0)
- [Hierarchy of control mechanisms of insulin secretion by glucose]. (1995) (0)
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