Jeannie T. Lee
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American geneticist
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Jeannie T. Leebiology Degrees
Biology
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Genetics
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Biology
Why Is Jeannie T. Lee Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jeannie T. Lee is a Professor of Genetics at Harvard Medical School and the Massachusetts General Hospital, and a Howard Hughes Medical Institute Investigator. She is known for her work on X-chromosome inactivation and for discovering the functions of a new class of epigenetic regulators known as long noncoding RNAs , including Xist and Tsix.
Jeannie T. Lee's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Long Noncoding RNAs: Past, Present, and Future (2013) (1627)
- Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome (2008) (1574)
- Epigenetic Regulation by Long Noncoding RNAs (2012) (1150)
- Genome-wide identification of polycomb-associated RNAs by RIP-seq. (2010) (967)
- Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. (2009) (854)
- Tsix, a gene antisense to Xist at the X-inactivation centre (1999) (820)
- Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences (2007) (715)
- X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease (2013) (613)
- Targeted Mutagenesis of Tsix Leads to Nonrandom X Inactivation (1999) (497)
- X chromosome dosage compensation: how mammals keep the balance. (2008) (480)
- YY1 Tethers Xist RNA to the Inactive X Nucleation Center (2011) (477)
- The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation (2010) (467)
- Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice (2013) (413)
- Transient Homologous Chromosome Pairing Marks the Onset of X Inactivation (2006) (413)
- Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations (2010) (394)
- LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. (2014) (385)
- Postmeiotic Sex Chromatin in the Male Germline of Mice (2006) (380)
- Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos (2003) (373)
- A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation (2015) (372)
- Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. (2009) (341)
- A 450 kb Transgene Displays Properties of the Mammalian X-Inactivation Center (1996) (329)
- Perinucleolar Targeting of the Inactive X during S Phase: Evidence for a Role in the Maintenance of Silencing (2007) (325)
- Long noncoding RNAs: fresh perspectives into the RNA world. (2014) (320)
- A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. (2006) (317)
- Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes (2015) (299)
- X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells (2008) (297)
- The pluripotency factor, Oct4, interacts with Ctcf and also controls X-chromosome pairing and counting (2009) (290)
- Long-range cis effects of ectopic X-inactivation centres on a mouse autosome (1997) (289)
- CTCF, a Candidate Trans-Acting Factor for X-Inactivation Choice (2001) (287)
- Intersection of the RNA Interference and X-Inactivation Pathways (2008) (287)
- Jpx RNA Activates Xist by Evicting CTCF (2013) (264)
- Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. (2007) (252)
- Regulatory interactions between RNA and polycomb repressive complex 2. (2014) (250)
- Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. (2003) (236)
- High-resolution Xist binding maps reveal 2-step spreading during X-inactivation (2013) (228)
- Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. (2017) (225)
- Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein (2007) (212)
- Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control (2011) (193)
- Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. (2015) (188)
- A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice (2001) (183)
- TERRA RNA Antagonizes ATRX and Protects Telomeres (2017) (170)
- Practical murine hematopathology: a comparative review and implications for research. (2015) (161)
- Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations (2012) (158)
- Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes (2007) (158)
- Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome (2010) (151)
- Regulation of X-Chromosome Counting by Tsix and Xite Sequences (2005) (144)
- Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain (2011) (141)
- Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF. (2015) (139)
- Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. (2012) (136)
- Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus (2008) (125)
- Two-Step Imprinted X Inactivation: Repeat versus Genic Silencing in the Mouse (2010) (121)
- Molecular Links between X-Inactivation and Autosomal Imprinting: X-Inactivation as a Driving Force for the Evolution of Imprinting? (2003) (120)
- X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny (2005) (118)
- ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets (2014) (113)
- Guided by RNAs: X-inactivation as a model for lncRNA function. (2013) (108)
- Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. (2019) (105)
- New and Xisting regulatory mechanisms of X chromosome inactivation. (2012) (104)
- SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X (2018) (102)
- The X chromosome in space (2017) (98)
- Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo (2006) (97)
- The X as model for RNA's niche in epigenomic regulation. (2010) (96)
- Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. (2013) (94)
- ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation (2012) (94)
- Tsix Transcription- versus RNA-Based Mechanisms in Xist Repression and Epigenetic Choice (2004) (93)
- Characterization and quantitation of differential Tsix transcripts: implications for Tsix function. (2003) (90)
- X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription (2011) (90)
- Sex chromosome silencing in the marsupial male germ line (2007) (86)
- X chromosome inactivation and epigenetic responses to cellular reprogramming. (2013) (85)
- Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation (2002) (85)
- Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. (2018) (84)
- Higher order chromatin structure at the X-inactivation center via looping DNA. (2008) (83)
- The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells (2015) (82)
- Identification of Developmentally Specific Enhancers for Tsix in the Regulation of X Chromosome Inactivation (2005) (82)
- The DXPas34 repeat regulates random and imprinted X inactivation. (2007) (79)
- Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1) (2017) (79)
- A Mammal-Specific Doublesex Homolog Associates with Male Sex Chromatin and Is Required for Male Meiosis (2007) (69)
- Destabilization of B2 RNA by EZH2 Activates the Stress Response (2016) (64)
- X-chromosome inactivation and the search for chromosome-wide silencers. (2002) (61)
- The search for a marsupial XIC reveals a break with vertebrate synteny (2007) (61)
- Female mice lacking Xist RNA show partial dosage compensation and survive to term (2016) (60)
- BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis (2014) (59)
- Mice Lacking Alkbh1 Display Sex-Ratio Distortion and Unilateral Eye Defects (2010) (59)
- Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos (2011) (59)
- Differential Methylation of Xite and CTCF Sites in Tsix Mirrors the Pattern of X-Inactivation Choice in Mice (2006) (58)
- A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders (2017) (58)
- X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells (2011) (57)
- New twists in X-chromosome inactivation. (2008) (54)
- LincRNA-p 21 Activates p 21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G 1 / S Checkpoint (2014) (50)
- Telomeric RNAs Mark Sex Chromosomes in Stem Cells (2009) (50)
- The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis (2019) (49)
- Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome (2018) (47)
- Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression (2017) (46)
- A Boundary Element Between Tsix and Xist Binds the Chromatin Insulator Ctcf and Contributes to Initiation of X-Chromosome Inactivation (2011) (46)
- PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments (2019) (43)
- PAR-TERRA directs homologous sex chromosome pairing (2017) (40)
- Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry. (2015) (40)
- Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space (2019) (39)
- XY and ZW: Is Meiotic Sex Chromosome Inactivation the Rule in Evolution? (2009) (38)
- Molecular biology: Complicity of gene and pseudogene (2003) (37)
- Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape (2018) (37)
- X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes. (2011) (37)
- Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome (2015) (36)
- X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. (2003) (36)
- Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator* (2015) (36)
- Coupling of X-Chromosome reactivation with the pluripotent stem cell state (2014) (30)
- Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut (2020) (27)
- Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. (2020) (25)
- Targeting Xist with compounds that disrupt RNA structure and X inactivation (2022) (25)
- Tsix–Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function (2018) (25)
- A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation (2016) (24)
- En bloc and segmental deletions of human XIST reveal X chromosome inactivation-involving RNA elements (2019) (24)
- B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2 (2019) (22)
- Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. (2018) (21)
- Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding (2020) (21)
- Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line (2015) (21)
- Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression. (2017) (21)
- Characterization of X-chromosome inactivation status in human pluripotent stem cells. (2010) (20)
- RNA in the loop. (2013) (20)
- Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation (2021) (19)
- Sex Chromosome Inactivation: The Importance of Pairing (2005) (19)
- Long non-coding RNAs: definitions, functions, challenges and recommendations. (2023) (18)
- Mapping of DNA Replication Origins to Noncoding Genes of the X-Inactivation Center (2006) (18)
- Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation. (2021) (17)
- Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops (2021) (17)
- An ex Vivo Model for Imprinting: Mutually Exclusive Binding of Cdx2 and Oct4 as a Switch for Imprinted and Random X-Inactivation (2012) (17)
- Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation. (2017) (16)
- Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition (2019) (15)
- Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett Syndrome. (2019) (14)
- ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets (2014) (14)
- Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover (2020) (13)
- Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression (2010) (12)
- Functional intergenic transcription: a case study of the X-inactivation centre. (2003) (11)
- Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient (2010) (11)
- Is X-chromosome inactivation a homology effect? (2002) (10)
- Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci (2013) (9)
- The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis (2021) (9)
- Reply to "Is Tsix repression of Xist specific to mouse?" (2003) (9)
- Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans (2018) (8)
- Homologous Genomic Fragments in the Mouse Pre-T Cell Receptor α (pTa) and Xist Loci ☆ (2000) (8)
- X-chromosome inactivation: a multi-disciplinary approach. (2003) (7)
- Comment on “Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing” (2017) (7)
- Measurement of pS2 protein in pancreatic cyst fluids (1998) (6)
- 2 Is X-chromosome inactivation a homology effect? (2002) (6)
- Genome-wide identification of autosomal genes with allelic imbalance of chromatin state (2017) (6)
- X-Chromosome Inactivation (1999) (6)
- Characterization of two Mst1‐deficient mouse models (2008) (5)
- iDRiP for the systematic discovery of proteins bound directly to noncoding RNA (2021) (5)
- Revisiting the consequences of deleting the X inactivation center (2021) (5)
- Four-dimensional chromosome reconstruction elucidates the spatiotemporal reorganization of the mammalian X chromosome (2021) (4)
- Revealing RCOR2 as a regulatory component of nuclear speckles (2021) (4)
- Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome. (2022) (4)
- Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding (2020) (3)
- Functional proteomic analysis of repressive histone methyltransferase complexes PRC2 and G9A reveals ZNF518B as a G9A regulator (2015) (3)
- Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming. (2023) (3)
- Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans (2019) (3)
- TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin (2022) (3)
- Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin (2022) (3)
- Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils. (2020) (2)
- Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome (2019) (2)
- A disproportionate impact of G9a methyltransferase deficiency on the X chromosome (2021) (2)
- Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans. (2019) (2)
- Extending the frontiers of epigenetic regulation. (2010) (2)
- Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on "Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence" by Karner et al. (2019). (2019) (2)
- Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils (2020) (2)
- Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover (2020) (2)
- Xist Repeat A contributes to early recruitment of Polycomb complexes during X-chromosome inactivation. (2021) (1)
- 21 Large Noncoding RNAs in Mammalian Gene Dosage Regulation (2006) (1)
- The roles of long noncoding RNA in epigenetic regulation (2013) (1)
- MacroRNAs in the Epigenetic Control of X-Chromosome Inactivation (2009) (1)
- Denaturing cross-linking immunoprecipitation to identify footprints for RNA-binding proteins (2021) (1)
- Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans. (2019) (1)
- Loss of H 3 K 27 me 3 Imprin ting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development Graphical (2018) (0)
- Retinoic Acid Accelerates Downregulation of the Xist Repressor , Oct 4 , and Increases the Likelihood of Xist Activation (2010) (0)
- tethers to the epigenome Lessons from X-chromosome inactivation : long ncRNA as guides and (2009) (0)
- Targeting Xist with compounds that disrupt RNA structure and X inactivation (2022) (0)
- X‐chromosome inactivation: Sex, heterochromatin, pairing, and noncoding RNA (2008) (0)
- Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape (2018) (0)
- Jeannie T. Lee (2008) (0)
- Complexity at large (2005) (0)
- Polymer modelling accurately predicts three-dimensional chromosome reorganization with a seasonal coronavirus infection (2023) (0)
- RNA-chromatin immunoprecipitations ( RNA-ChIP ) in mammalian cells ( PROT 28 ) (2007) (0)
- Revealing RCOR2 as a regulatory component of nuclear speckles (2021) (0)
- Identification of Developmentally Specific Enhancers for Tsix in the Regulation of X Chromosome Inactivation (2005) (0)
- Targeting RNA with small molecules: lessons learned from Xist RNA (2023) (0)
- PAR-TERRA directs homologous sex chromosome pairing this access benefits you. Your story matters (2017) (0)
- Mst 1 and Mst 2 maintain hepatocyte quiescence and suppress the development of hepatocellular carcinoma through inactivation of the Yap 1 oncogene (2011) (0)
- The Inactive X Chromosome Is Folded Like Origami By SMCHD1 (2018) (0)
- Effects of forced cohesin eviction and retention on X-inactivation and autosomes (2021) (0)
- 1 2 3 4 5 Exploration of CTCF post-translation modifications uncovers Serine-224 6 phosphorylation by PLK 1 at pericentric regions during the G 2 / M transition 7 8 9 10 (0)
- Decision letter: In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation (2019) (0)
- ATRX Promotes Binding of PRC2 to Xist RNA and Polycomb Targets (2015) (0)
- Prions as a cause of infectious, genetic, and sporadic neurodegenerative diseases (1995) (0)
- The roles of long noncoding RNA in epigenetic regulation (2013) (0)
- PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments (2019) (0)
- Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation (2021) (0)
- 4D chromosome reconstruction elucidates the spatial reorganization of the mammalian X-chromosome (2021) (0)
- The X-chromosome archetype for non-coding RNA regulation of the epigenome (2012) (0)
- Polycomb stations Spreading of X chromosome inactivation via a hierarchy of defined Material Supplemental (2012) (0)
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