Jean-Pierre Changeux | Academic Influence

Jean-Pierre Changeux's AcademicInfluence.com Rankings

Jean-Pierre Changeux

Biology

#211

World Rank

#385

Historical Rank

Neuroscience

#45

World Rank

#47

Historical Rank

biology Degrees

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Biology

Jean-Pierre Changeux's Degrees

PhD Medicine Université Paris Cité

Why Is Jean-Pierre Changeux Influential?

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According to Wikipedia, Jean-Pierre Changeux is a French neuroscientist known for his research in several fields of biology, from the structure and function of proteins , to the early development of the nervous system up to cognitive functions. Although being famous in biological sciences for the MWC model, the identification and purification of the nicotinic acetylcholine receptor and the theory of epigenesis by synapse selection are also notable scientific achievements. Changeux is known by the non-scientific public for his ideas regarding the connection between mind and physical brain. As put forth in his book, Conversations on Mind, Matter and Mathematics, Changeux strongly supports the view that the nervous system functions in a projective rather than reactive style and that interaction with the environment, rather than being instructive, results in the selection amongst a diversity of preexisting internal representations.

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Jean-Pierre Changeux's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. (1965) (7371)
Conscious, preconscious, and subliminal processing: a testable taxonomy (2006) (1770)
Allosteric proteins and cellular control systems. (1963) (1723)
Experimental and Theoretical Approaches to Conscious Processing (2011) (1707)
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine (1998) (1288)
Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks (1976) (1235)
A neuronal model of a global workspace in effortful cognitive tasks. (1998) (964)
Nicotinic receptors at the amino acid level. (2000) (807)
A neuronal network model linking subjective reports and objective physiological data during conscious perception (2003) (714)
Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei (2001) (685)
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation (2009) (676)
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system (2009) (667)
Development of Elementary Numerical Abilities: A Neuronal Model (1993) (666)
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain (1995) (650)
Allosteric Mechanisms of Signal Transduction (2005) (641)
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. (1999) (599)
Acetylcholine receptor: an allosteric protein. (1984) (578)
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits (1999) (569)
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors (2005) (562)
Use of a snake venom toxin to characterize the cholinergic receptor protein. (1970) (529)
Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice (2003) (522)
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor (1991) (519)
A Neuronal Model of Predictive Coding Accounting for the Mismatch Negativity (2012) (448)
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice (2010) (425)
Allosteric receptors after 30 years (1998) (420)
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice (1998) (420)
Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic (1992) (417)
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel (2011) (413)
The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences. (2002) (408)
Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities (1993) (403)
Neuronal Nicotinic Receptor a6 Subunit mRNA is Selectively Concentrated in Catecholaminergic Nuclei of the Rat Brain (1996) (403)
Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor. (1993) (399)
On the cooperativity of biological membranes. (1967) (366)
Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice (2002) (363)
Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) (354)
Structural and functional properties of the acetylcholine receptor protein in its purified and membrane-bound states. (1978) (350)
Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation (1992) (348)
The Wisconsin Card Sorting Test: theoretical analysis and modeling in a neuronal network. (1991) (346)
Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein. (1984) (327)
Large-scale purification of the acetylcholine-receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ. (1977) (324)
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement 1 Published on the World Wide Web on 24 October 1997. 1 (1998) (318)
Crucial Role of α4 and α6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration (2008) (317)
Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. (1998) (313)
Ongoing Spontaneous Activity Controls Access to Consciousness: A Neuronal Model for Inattentional Blindness (2005) (308)
Allostery and the Monod-Wyman-Changeux model after 50 years. (2012) (307)
Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells (1995) (305)
Neuronal man : the biology of mind (1985) (302)
Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes (1986) (301)
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family (2007) (300)
Nicotinic receptor function: new perspectives from knockout mice. (2000) (299)
On the nature of allosteric transitions: implications of non-exclusive ligand binding. (1966) (284)
Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site. (1988) (282)
Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors (2006) (277)
Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. (1983) (275)
Nicotine Upregulates Its Own Receptors through Enhanced Intracellular Maturation (2005) (273)
Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs. (1966) (272)
Neural networks that learn temporal sequences by selection. (1987) (270)
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine. (1986) (268)
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites (2002) (267)
Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors (2003) (261)
A theory of the epigenesis of neuronal networks by selective stabilization of synapses. (1973) (251)
Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways (1987) (236)
Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system (2001) (235)
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. (1992) (235)
Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit (1993) (233)
Role of Ca2+ Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus (1997) (233)
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. (2020) (233)
Conformational selection or induced fit? 50 years of debate resolved (2011) (231)
Acetylcholine receptor gene expression at the developing neuromuscular junction. (1995) (219)
Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors (1999) (218)
Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from torpedo marmorata. (1983) (217)
Purification and properties of the cholinergic receptor protein from Electrophorus electricus electric tissue. (1974) (217)
Networks of Formal Neurons and Memory Palimpsests (1986) (207)
Neurotransmitter-gated ion channels as unconventional allosteric proteins (1994) (204)
Structure and pharmacology of pentameric receptor channels: from bacteria to brain. (2012) (204)
Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells. (1988) (201)
Targeting Transcription to the Neuromuscular Synapse (2001) (200)
Neuronal models of cognitive functions (1989) (200)
Abnormal Functional Organization in the Dorsal Lateral Geniculate Nucleus of Mice Lacking the β2 Subunit of the Nicotinic Acetylcholine Receptor (2003) (198)
Allostery in Its Many Disguises: From Theory to Applications. (2019) (196)
Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs (2008) (194)
The acetylcholine receptor: an "allosteric" membrane protein. (1979) (194)
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. (2005) (194)
Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures (2007) (191)
The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily* (2012) (190)
Potentiation of nicotinic receptor response by external calcium in rat central neurons (1992) (190)
Denervation increases a neurite-promoting activity in extracts of skeletal muscle (1983) (189)
Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata (1973) (189)
The feedback control mechanisms of biosynthetic L-threonine deaminase by L-isoleucine. (1961) (188)
A hierarchical neuronal network for planning behavior. (1997) (188)
Calcitonin gene‐related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger. (1987) (188)
Consequences of tenotomy on the evolution of multiineervation in developing rat soleus muscle (1975) (187)
The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice (2006) (186)
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation (2013) (185)
International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands (2014) (183)
Neural Mechanisms for Access to Consciousness (2004) (180)
Allosteric modulations of the nicotinic acetylcholine receptor (1993) (179)
Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons. (1999) (176)
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains. (1987) (175)
Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata. (1979) (171)
Executive and social behaviors under nicotinic receptor regulation (2003) (170)
Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum (2001) (170)
Allosteric interactions in aspartate transcarbamylase. I. Binding of specific ligands to the native enzyme and its isolated subunits. (1968) (167)
Functional architecture of the nicotinic acetylcholine receptor: A prototype of ligand-gated ion channels (1993) (165)
Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. I. Binding of the tritiated alpha-neurotoxin in the absence of effector. (1974) (164)
Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis (1991) (162)
Nicotinic receptors in wonderland. (2001) (161)
The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis (1992) (156)
The Emergence of Human Consciousness: From Fetal to Neonatal Life (2009) (155)
Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation (2016) (150)
Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata. (1975) (148)
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue (2010) (147)
Introducing the Human Brain Project (2011) (146)
A Neuronal Model of a Global Workspace in Effortful Cognitive Tasks (2001) (146)
Working memory, response selection, and effortful processing in rats with medial prefrontal lesions. (1994) (145)
Distinct contributions of nicotinic acetylcholine receptor subunit α4 and subunit α6 to the reinforcing effects of nicotine (2011) (145)
Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes. (1998) (143)
Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor (1999) (142)
Induction of utrophin gene expression by heregulin in skeletal muscle cells: role of the N-box motif and GA binding protein. (1999) (140)
Nicotine and serotonin in immune regulation and inflammatory processes: a perspective (2007) (140)
A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions (1996) (139)
Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation. (1989) (139)
Identification of a New Component of the Agonist Binding Site of the Nicotinic 7 Homooligomeric Receptor (*) (1995) (139)
The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain. (1997) (137)
A Simple Model of Prefrontal Cortex Function in Delayed-Response Tasks (1989) (137)
Purification fromTorpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor protein (1972) (136)
Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick (1989) (136)
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia (2017) (136)
On the excitability and cooperativity of the electroplax membrane. (1968) (136)
ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate. (1995) (134)
50 years of allosteric interactions: the twists and turns of the models (2013) (134)
Spin glass model of learning by selection. (1986) (134)
Rapsyn Escorts the Nicotinic Acetylcholine Receptor Along the Exocytic Pathway via Association with Lipid Rafts (2002) (134)
Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit. (1999) (133)
Allosteric Interactions on Biosynthetic L-threonine Deaminase from E. coli K12 (1963) (130)
Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin. (1974) (130)
Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement (2013) (130)
Regulation of muscle AChR α subunit gene expression by electrical activity: Involvement of protein kinase C and Ca 2+ (1989) (127)
Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. (2005) (127)
Nicotinic receptors, allosteric proteins and medicine. (2008) (127)
Reward-dependent learning in neuronal networks for planning and decision making. (2000) (127)
The TiPS lecture. The nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels. (1990) (126)
A gating mechanism of pentameric ligand-gated ion channels (2013) (126)
The Global Neuronal Workspace Model of Conscious Access: From Neuronal Architectures to Clinical Applications (2011) (125)
Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves (2005) (125)
The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. (2006) (123)
Nicotine activates immature “silent” connections in the developing hippocampus (2003) (123)
Allosteric interactions in aspartate transcarbamylase. 3. Interpretation of experimental data in terms of the model of Monod, Wyman, and Changeux. (1968) (123)
Activity regulates the levels of acetylcholine receptor alpha-subunit mRNA in cultured chicken myotubes. (1985) (122)
Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system. (2002) (121)
Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin. (1978) (118)
Some physical properties of the cholinergic receptor protein from Electrophorus electricus revealed by a tritiated alpha-toxin from Naja nigricollis venom. (1972) (116)
Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations (1976) (116)
Identification of a DNA element determining synaptic expression of the mouse acetylcholine receptor delta-subunit gene. (1995) (114)
Allosteric receptors: from electric organ to cognition. (2010) (112)
Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine (2001) (111)
Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor (2002) (110)
Allosteric modulation as a unifying mechanism for receptor function and regulation (2017) (110)
Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ (1981) (110)
Molecular tuning of fast gating in pentameric ligand-gated ion channels. (2005) (110)
The Ligand Gated Ion Channel Database (1999) (109)
Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors (2001) (109)
Ethanol inhibition of nicotinic acetylcholine type alpha 7 receptors involves the amino-terminal domain of the receptor. (1996) (108)
Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. (2004) (108)
Allosteric nicotinic receptors, human pathologies (1998) (107)
The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation (2015) (107)
β2-Containing Nicotinic Receptors Contribute to the Organization of Sleep and Regulate Putative Micro-Arousals in Mice (2004) (106)
Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata. (1974) (106)
Ultrastructural Localization of the α4-Subunit of the Neuronal Acetylcholine Nicotinic Receptor in the Rat Substantia Nigra (1999) (106)
Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders (1997) (104)
Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors (1998) (104)
The nicotinic acetylcholine receptor: Molecular architecture of a ligand-regulated ion channel (1987) (104)
Interaction of the acetylcholine (nicotinic) receptor protein from Torpedo marmorata electric organ with monolayers of pure lipids. (1978) (103)
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]α‐bungarotoxin binding sites in the brain of Macaca mulatta (2003) (103)
Working memory, response selection, and effortful processing in rats with medial prefrontal lesions (1994) (103)
The multiple phenotypes of allosteric receptor mutants. (1996) (103)
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in αCGRP-deficient mice (2001) (102)
Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors (2006) (102)
Implication of a multisubunit Ets‐related transcription factor in synaptic expression of the nicotinic acetylcholine receptor (1998) (101)
Regulation of muscle acetylcoline receptor synthesis in vitro by cyclic nucleotide derivatives (1979) (101)
Identification of an Element Crucial for the Sub-synaptic Expression of the Acetylcholine Receptor ε-Subunit Gene* (1996) (101)
Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata. (1983) (101)
Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus. (1973) (99)
Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries (2002) (99)
Long-term effects of chronic nicotine exposure on brain nicotinic receptors (2007) (99)
Nicotinic receptor: an allosteric protein specialized for intercellular communication (1995) (98)
Nicotinic and muscarinic receptors in the rat prefrontal cortex: Differential roles in working memory, response selection and effortful processing (1995) (98)
In vitro phosphorylation of the acetylcholine receptor (1977) (97)
The role of nicotinic receptors in B-lymphocyte development and activation. (2007) (96)
Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata. (1981) (96)
Fast kinetic studies on the allosteric interactions between acetylcholine receptor and local anesthetic binding sites. (1979) (96)
Transmembrane orientation of proteins present in acetylcholine receptor-rich membranes from Torpedo marmorata studied by selective proteolysis. (1980) (96)
Prefrontal nicotinic receptors control novel social interaction between mice (2011) (95)
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. IV. Quinacrine: a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane-bound state. (1976) (95)
Consequences of blocking the nerve with a local anaesthetic on the evolution of multiinnervation at the regenerating neuromuscular junction of the rat (1978) (95)
Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: Dependence on cholinergic nicotinic and dopaminergic D1 receptors (2006) (92)
Effects of a snake alpha-neurotoxin on the development of innervated skeletal muscles in chick embryo. (1973) (92)
Control of neurulation by the nucleosome assembly protein-1–like 2 (2000) (92)
Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation. (1999) (92)
Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. (1999) (92)
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. II. The permeability response of the receptor-rich membrane fragments to cholinergic agonists in vitro. (1976) (90)
The acetylcholine receptor: an "allosteric" membrane protein. (1979) (90)
Conversations on mind, matter, and mathematics (1995) (89)
Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors (2010) (88)
Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: resolution of an "intermediate" conformational transition and evidence for positive cooperative effects. (1980) (88)
Conditions for the selective labelling of the 66 000 dalton chain of the acetylcholine receptor by the covalent non‐competitive blocker 5‐azido‐[3H]trimethisoquin (1980) (88)
Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques (1975) (88)
Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice (1999) (88)
On Some Structural Analogies between Acetylcholinesterase and the Macromolecular Receptor of Acetylcholine (1969) (87)
An acetylcholine receptor alpha‐subunit promoter conferring preferential synaptic expression in muscle of transgenic mice. (1991) (87)
Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord (2004) (87)
An Extracellular Protein Microdomain Controls Up-regulation of Neuronal Nicotinic Acetylcholine Receptors by Nicotine* (2004) (85)
Some structural properties of the cholinergic receptor protein in its membrane environmental relevant to its function as a pharmacological receptor. (1976) (85)
β2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure (2002) (85)
Nicotine enhances intracellular nicotinic receptor maturation: A novel mechanism of neural plasticity? (2006) (85)
Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine (2006) (85)
The cholinergic receptor protein in its membrane environment. (1975) (85)
Tritium labelling of the α-neurotoxin of Naja nigricollis (1971) (84)
Compartmentalization of cold-stable and acetylated microtubules in the subsynaptic domain of chick skeletal muscle fibre (1990) (84)
A neurocomputational hypothesis for nicotine addiction. (2006) (83)
Interplay of β2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion (2008) (83)
Origins of the Human Brain (1995) (82)
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors (2015) (82)
Nicotinic receptors regulate B lymphocyte activation and immune response. (2005) (82)
Localization of the cholinergic receptor protein in Electrophorus electroplax by high resolution autoradiography (1972) (82)
Stratification of the channel domain in neurotransmitter receptors. (1993) (80)
Live imaging of neural structure and function by fibred fluorescence microscopy (2006) (79)
The rotational diffusion of the acetylcholine receptor in Torpeda marmorata membrane fragments studied with a spin‐labelled alpha‐toxin: importance of the 43 000 protein(s). (1982) (79)
Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics. (1986) (79)
In vivo and in vitro analysis of electrical activity-dependent expression of muscle acetylcholine receptor genes using adenovirus. (1994) (78)
Paradoxical allosteric effects of competitive inhibitors on neuronal α7 nicotinic receptor mutants (1997) (78)
Calcitonin gene-related peptide and cyclic AMP stimulate phosphoinositide turnover in skeletal muscle cells. Interaction between two second messenger systems. (1989) (77)
Learning by Selection (1984) (77)
Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines. (2003) (76)
The Physiology of Truth: Neuroscience and Human Knowledge (2004) (76)
LGICdb: the ligand-gated ion channel database (2001) (76)
{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation. (2009) (75)
Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations. (1984) (75)
Pharmacological profile of nicotinic acetylcholine receptors in the rat prefrontal cortex: An electrophysiological study in a slice preparation (1989) (74)
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. III. Pharmocological desensitization in vitro of the receptor-rich membrane fragments by cholinergic agonists. (1976) (74)
50th anniversary of the word “allosteric” (2011) (73)
Reconstitution of a chemically excitable membrane. (1974) (73)
Towards a cognitive neuroscience of self-awareness (2017) (73)
Multiple affinity states for noncompetitive blockers revealed by [3H]phencyclidine binding to acetylcholine receptor rich membrane fragments from Torpedo marmorata. (1983) (73)
Transmembrane topology of acetylcholine receptor subunits probed with photoreactive phospholipids. (1985) (72)
Interconversion between different states of affinity for acetylcholine of the cholinergic receptor protein from Torpedo marmorata. (1975) (72)
Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints (2002) (71)
Reconstitution of a Functional Acetylcholine Receptor (1980) (69)
Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function. (2000) (69)
Affinity labeling of the acetylcholine-receptor. (1967) (69)
Evolution of cholinergic proteins in developing slow and fast skeletal muscles in chick embryo. (1980) (69)
Heterogeneity and Selective Targeting of Neuronal Nicotinic Acetylcholine Receptor (nAChR) Subtypes Expressed on Retinal Afferents of the Superior Colliculus and Lateral Geniculate Nucleus: Identification of a New Native nAChR Subtype α3β2(α5 or β3) Enriched in Retinocollicular Afferents (2005) (69)
Intracellular complexes of the β2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics (2007) (68)
Developmental Regulation of Acetylcholinesterase Transcripts in the Mouse Diaphragm: Alternative Splicing and Focalization (1995) (68)
Influence of innervation of myogenic factors and acetylcholine receptor alpha-subunit mRNAs. (1991) (68)
A 5'-flanking region of the chicken acetylcholine receptor alpha-subunit gene confers tissue specificity and developmental control of expression in transfected cells (1987) (68)
Reconstitution of a functional acetylcholine receptor. Conservation of the conformational and allosteric transitions and recovery of the permeability response; role of lipids. (1980) (68)
Differential expression of the neuronal acetylcholine receptor α2 subunit gene during chick brain development (1990) (67)
Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome (2006) (67)
Cholinergic receptor protein of Electrophorus electricus. II. Physical properties of the cholinergic receptor protein from Electrophorus electricus revealed by a tritiated α-toxin from Naja nigricollis venom (1972) (67)
Pore conformations and gating mechanism of a Cys-loop receptor. (2005) (67)
Phosphorylation in vitro of membrane fragments from Torpedo marmorata electric organ. Effect on membrane solubilization by detergents. (1980) (65)
Fast kinetic studies on the interaction of cholinergic agonists with the membrane-bound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence. (1977) (65)
Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation (1982) (64)
The role of nicotinic acetylcholine receptors in lymphocyte development (2006) (64)
The noncompetitive blocker [3H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit (1989) (64)
Chemical signaling in the brain. (1993) (64)
Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice (2006) (64)
Interaction of a fluorescent ligand with membrane-bound cholinergic receptor from Torpedo marmorata. (1973) (64)
The acetylcholine receptor molecule: allosteric sites and the ion channel (1987) (63)
On the mode of action of colicins: a model of regulation at the membrane level. (1967) (62)
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. (2010) (61)
The concept of allosteric modulation: an overview. (2013) (61)
Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative. (1988) (60)
An H‐bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors (2003) (60)
An 83-nucleotide promoter of the acetylcholine receptor epsilon-subunit gene confers preferential synaptic expression in mouse muscle. (1993) (59)
Production and characterization of a monoclonal antibody directed against the 43,000-dalton v1 polypeptide from Torpedo marmorata electric organ. (1983) (59)
The nicotinic acetylcholine receptor: a typical ‘allosteric machine’ (2018) (59)
Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice (2012) (58)
Effects associated with Permeability Changes caused by Gramicidin A in Electroplax Membrane (1969) (58)
Studies on the effect of histrionicotoxin on the monocellular electroplax from Electrophorus electricus and on the binding of (3H)acetylcholine to membrane fragments from Torpedo marmorata. (1976) (57)
Genetic and 'epigenetic' factors regulating synapse formation in vertebrate cerebellum and neuromuscular junction. (1978) (57)
Monitoring protein interactions in the living cell through the fluorescence decays of the cyan fluorescent protein. (2006) (56)
A simple molecular model of neurulation. (1998) (55)
Pharmacological and null mutation approaches reveal nicotinic receptor diversity. (2000) (55)
Attention-deficit/hyperactivity disorder: a plausible mouse model? (2006) (54)
Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. 3. Effects of local anaesthetics on the binding of the tritiated alpha-neurotoxin. (1974) (54)
Allosteric transitions of the acetylcholine receptor. (1998) (53)
Asymmetric distribution of dystrophin in developing and adult Torpedo marmorata electrocyte: evidence for its association with the acetylcholine receptor-rich membrane. (1990) (53)
Stratified organization of the nicotinic acetylcholine receptor channel. (1992) (53)
In vitro interaction of 1-anilino 8 naphthalene sulfonate with excitable membranes isolated from the electric organ of Electrophorus electricus. (1969) (52)
Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors. (2000) (52)
The amino‐terminal sequence of the 40 000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata (1979) (52)
Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe quinacrine. (1976) (52)
Evidence for a polarity in the distribution of proteins from the cytoskeleton in Torpedo marmorata electrocytes (1986) (51)
Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition (2005) (51)
Modulation of morphine analgesia in αcgrp mutant mice (1999) (51)
Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit. (2001) (50)
Analysis of the cellular expression pattern of β‐CGRP in α‐CGRP‐deficient mice (2004) (50)
Selective labeling of the delta subunit of the acetylcholine receptor by a covalent local anesthetic. (1981) (49)
Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation. (1986) (49)
αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors (2014) (48)
Stabilization of complex input-output functions in neural clusters formed by synapse selection (1992) (48)
An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis. (1998) (48)
Immunoreactive Calcitonin Gene‐Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in Developing Chicken Spinal Cord Motoneurons (1989) (47)
Existence and coexistence of calcitonin gene-related peptide, vasoactive intestinal polypeptide- and somatostatin-like immunoreactivities in spinal cord motoneurons of developing embryos and post-hatch chicks (1988) (47)
Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor. (1982) (47)
SYNAPTIC PLASTICITY AS BASIS OF BRAIN ORGANIZATION (47)
Recovery of some functional properties of the detergent-extracted cholinergic receptor protein from Torpedo marmorata after reintegration into a membrane environment. (1978) (46)
Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression (2002) (45)
Image analysis of the heavy form of the acetylcholine receptor from Torpedo marmorata. (1984) (45)
Dissection of the 66 000-dalton subunit of the acetylcholine receptor. (1981) (44)
The acetylcholine receptor (1979) (44)
Synthesis of fluorescent acyl‐cholines with agonistic properties: pharmacological activity on Electrophorus electroplaque and interaction in vitro with Torpedo receptor‐rich membrane fragments (1976) (44)
Compartmentalized transcription of acetylcholine receptor genes during motor endplate epigenesis. (1991) (43)
Long-Term Exposure to Nicotine Modulates the Level and Activity of Acetylcholine Receptors in White Blood Cells of Smokers and Model Mice (2004) (43)
Change in state of phosphorylation of acetylcholine receptor during maturation of the electromotor synapse in Torpedo marmorata electric organ. (1981) (42)
Reconstitution of a functional acetylcholine receptor. Incorporation into artificial lipid vesicles and pharmacology of the agonist-controlled permeability changes. (2005) (42)
Phosphorylation of myogenin in chick myotubes: regulation by electrical activity and by protein kinase C. Implications for acetylcholine receptor gene expression. (1994) (42)
Neurobiology of human values (2005) (42)
Regulation of enzyme activity and allosteric interactions (1968) (42)
Altered paralimbic interaction in behavioral addiction (2013) (41)
Lipid-dependent recovery of alpha-bungarotoxin and monoclonal antibody binding to the purified alpha-subunit from Torpedo marmorata acetylcholine receptor. Enhancement by noncompetitive channel blockers. (1984) (41)
14-3-3 γ associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse (2004) (41)
Morphological and biochemical studies on isolated molecular and granular layers from bovine cerebellum (1978) (41)
A photoaffinity ligand of the acetylcholine‐binding site predominantly labels the region 179–207 of the α‐subunit on native acetylcholine receptor from Torpedo marmorata (1986) (41)
Climbing Brain Levels of Organisation from Genes to Consciousness (2017) (41)
Contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine. (1997) (39)
Conscious processing: implications for general anesthesia (2012) (39)
A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels. (2005) (39)
Selective labelling by [3H]trimethisoquin azide of polypeptide chains present in acetylcholine receptor‐rich membranes from Torpedo marmorata (1980) (39)
Localization of Acetylcholinesterase by Immunofluorescence in Eel Electroplax (1970) (39)
Post‐transcriptional Compartmentalization of Acetylcholine Receptor Biosynthesis in the Subneural Domain of Muscle and Electrocyte Junctions (1993) (39)
Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor alpha 2 subunit gene. (1993) (38)
Spin glass model of learning by selection (1987) (38)
Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration (2008) (38)
Characterization and developmental evolution of a high-affinity binding site for calcitonin gene-related peptide on chick skeletal muscle membrane (1991) (37)
The natural axis of transmitter receptor distribution in the human cerebral cortex (2020) (37)
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe. (2002) (37)
The Neuronal Workspace Model: Conscious Processing and Learning (2008) (37)
Oral administration of a dual analog of two myasthenogenic T cell epitopes down-regulates experimental autoimmune myasthenia gravis in mice. (2000) (37)
Functional determinants by which snake and cone snail toxins block the α7 neuronal nicotinic acetylcholine receptors (1998) (36)
The Cholinergic Receptor Protein from Fish Electric Organ (1975) (36)
Object memory in young and aged mice after sevoflurane anaesthesia (2009) (36)
Isolation and purification of the nicotinic acetylcholine receptor and its functional reconstitution into a membrane environment. (1977) (35)
Effects of the type A toxin fromClostridium botulinum on the development of skeletal muscles and of their innervation in chick embryo (1975) (35)
The Role of β2‐Subunit‐Containing Nicotinic Acetylcholine Receptors in the Brain Explored with a Mutant Mouse (1999) (35)
Neuronal Models of Prefrontal Cortical Functions (1995) (35)
Inhibition of both α7* and β2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum (2006) (35)
THE CONTROL OF BIOCHEMICAL REACTIONS. (1965) (35)
Some structural properties of excitable membranes labelled by fluorescent probes (1970) (35)
A Connectomic Hypothesis for the Hominization of the Brain (2020) (35)
Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid–detergent matrices (2003) (35)
A versatile system for the neuronal subtype specific expression of lentiviral vectors (2010) (35)
The Ligand Gated Ion Channel database: an example of a sequence database in neuroscience. (2001) (35)
Acetylcholine receptor expression in primary cultures of embryonic chick myotubes—I. Discoordinate regulation of α-, γ- and δ-subunit gene expression by calcitonin gene-related peptide and by muscle electrical activity (1989) (34)
Consequences of denervation on the distribution of the cholinergic (nicotinic) receptor sites from Electrophorus electricus revealed by high resolution autoradiography. (1973) (34)
Purification of membrane fragments derived from the non excitable surface of the eel electroplax (1970) (33)
Asynchronous assembly of the acetylcholine receptor and of the 43-kD nu1 protein in the postsynaptic membrane of developing Torpedo marmorata electrocyte (1989) (33)
Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor. (2002) (33)
Anti-COVID-19 efficacy of ivermectin in the golden hamster (2020) (33)
Quantitative studies on the localization of the cholinergic receptor protein in the normal and denervated electroplaque from Electrophorus electricus (1978) (33)
Serine-specific phosphorylation of nicotinic receptor associated 43K protein. (1991) (33)
Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation (2007) (32)
A protein difference associated with defects of the purkinje cell in staggerer and nervous mutant mice (1975) (31)
Nerve‐Dependent Plasticity of the Golgi Complex in Skeletal Muscle Fibres: Compartmentalization Within the Subneural Sarcoplasm (1995) (31)
The Cognitive Neurosciences IV (2014) (30)
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin (2021) (30)
Emergent pharmacology of conscious experience: new perspectives in substance addiction (2011) (30)
Use of knock-out mice to determine the molecular basis for the actions of nicotine. (1999) (29)
Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics (2017) (29)
Phosphorylation-Elicited Quaternary Changes of GA Binding Protein in Transcriptional Activation (2003) (29)
Ultrastructural localization of the alpha4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra. (1999) (29)
A model for reading morphogenetic gradients: autocatalysis and competition at the gene level. (1994) (29)
Allosteric regulation of pentameric ligand-gated ion channels (2014) (29)
On the irreversible binding of p‐(trimethylammonium) benzenediazonium fluoroborate (TDF) to acetylcholinesterase from electrogenic tissue (1969) (29)
Evidence for degradation of the acetylcholine (nicotinic) receptor in skeletal muscle during the development of the chick embryo (1977) (28)
Computational models of association cortex (2000) (28)
Voltage dependencies of the effects of chlorpromazine on the nicotinic receptor channel from mouse muscle cell line Sol8 (1993) (28)
Membrane excitability and dissipative instabilities (1970) (28)
Increase of neurite-promoting activity for spinal neurons in muscles of 'paralysé' mice and tenotomised rats. (1986) (28)
Mechanism of Cl- Selection by a Glutamate-gated Chloride (GluCl) Receptor Revealed through Mutations in the Selectivity Filter* (2006) (28)
Nicotinic acetylcholine receptors (2008) (27)
The Physiology of Truth (2002) (27)
The Ferrier Lecture 1998 The molecular biology of consciousness investigated with genetically modified mice (2006) (27)
Chapter 26 Coexistence of neuronal messengers and molecular selection (1986) (27)
Single binding versus single channel recordings: a new approach to study ionotropic receptors. (1997) (27)
Variation and selection in neural function. (1997) (27)
Knock-out and knock-in mice to investigate the role of nicotinic receptors in the central nervous system. (2002) (27)
Rational understanding of nicotinic receptors drug binding. (2004) (27)
Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels. (1999) (26)
New mutants to explore nicotinic receptor functions. (1992) (26)
Basic consciousness of the newborn. (2010) (26)
Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing (2016) (26)
Calcium-dependent effect of the thymic polypeptide thymopoietin on the desensitization of the nicotinic acetylcholine receptor. (1987) (26)
Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors. (1996) (26)
The acetylcholine receptor: functional architecture and regulation. (1990) (25)
Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment. (2012) (25)
Nicotinic-agonist stimulated 86Rb+ efflux and [3H]epibatidine binding of mice differing in β2 genotype (2000) (25)
Compared effects of dithiotreitol on the interaction of an affinity-labeling reagent with acetylcholinesterase and the excitable membrane of the electroplax. (1969) (25)
Relationships between Structural Dynamics and Functional Kinetics in Oligomeric Membrane Receptors (2010) (25)
Modulation of morphine analgesia in alphaCGRP mutant mice. (1999) (25)
Human Brain Project (2014) (24)
Transdisciplinary EU science institute needs funds urgently (2010) (24)
to the activation mechanism (24)
Chronic Nicotine Exposure has Dissociable Behavioural Effects on Control and Beta2−/− Mice (2008) (24)
Chronic stimulation of the spinal cord in developing chick embryo causes the differentiation of multiple clusters of acetylcholine receptor in the posterior latissimus dorsi muscle. (1980) (24)
Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors (2016) (24)
Nicotinic receptors and nicotine addiction. (2009) (24)
In Vitro excitation of purified membrane fragments by cholinergic agonists (1971) (24)
Differences between detergent-extracted acetylcholine receptor and “cholinergic proteolipid” (1975) (24)
What Makes Us Think? (2000) (24)
Acquisition and performance of delayed-response tasks: a neural network model. (2005) (24)
A subpopulation of embryonic telencephalic neurons survive and develop in vitro in response to factors derived from the periphery. (1987) (23)
Presence of two forms of acetylcholine receptor with different isoelectric points in the electric organ of Electrophorus electricus and their catalytic interconversion in vitro (1976) (23)
A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain (2001) (23)
Neuronal Nicotinic Acetylcholine Receptors in the Brain (1996) (23)
ALLOSTERIC INTERACTIONS INTERPRETED IN TERMS OF QUATERNARY STRUCTURE. (1964) (23)
Chicken neuronal acetylcholine receptor alpha 2-subunit gene exhibits neuron-specific expression in the brain and spinal cord of transgenic mice. (1993) (23)
Art and Neuroscience (2017) (23)
Chromosomal localization of the mouse genes coding for α2, α3, α4 and β2 subunits of neuronal nicotinic acetylcholine receptor (1990) (23)
Purification and characterization of the cholinergic receptor protein in its membrane-bound and detergent-soluble forms from the electric organ of Torpedo marmorata. (1977) (22)
The Concept of Allosteric Interaction and Its Consequences for the Chemistry of the Brain (2013) (22)
In vitro excitation of purified membrane fragments by cholinergic agonists (1971) (21)
Loss of high‐affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment (2007) (21)
Compartmentalized Expression of the α- and γ-Subunits of the Acetylcholine Receptor in Recently Fused Myofibers (1993) (21)
Induction of normal ultrastructure by CGRP treatment in dysgenic myotubes (1990) (21)
A hierarchical coherent‐gene‐group model for brain development (2013) (20)
Induction of acetylcholine receptor alpha-subunit gene expression in chicken myotubes by blocking electrical activity requires ongoing protein synthesis. (1990) (20)
A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes. (2008) (20)
Direct involvement of a lamin-B-related (54 kDa) protein in the association of intermediate filaments with the postsynaptic membrane of the Torpedo marmorata electrocyte. (1995) (20)
Control of breathing in newborn mice lacking the beta-2 nAChR subunit. (2004) (20)
Concluding remarks: on the "singularity" of nerve cells and its ontogenesis. (1983) (20)
Electrical Phenomena Associated with the Activity of the Membrane-Bound Acetylcholinesterase (1967) (20)
Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor (2020) (20)
Allosteric proteins after thirty years: The binding and state functions of the neuronalα7 nicotinic acetylcholine receptors (1996) (20)
The nicotinic acetylcholine receptor: From molecular biology to cognition (2015) (19)
The origins of allostery: from personal memories to material for the future. (2013) (19)
Nonmyogenic Factors Bind Nicotinic Acetylcholine Receptor Promoter Elements Required for Response to Denervation* (1998) (19)
Raman spectroscopy of acetylcholine receptor‐rich membranes from Torpedo marmorata and of their isolated components (1983) (19)
Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy. (2000) (18)
Phorbol esters inhibit the activity of the chicken acetylcholine receptor α-subunit gene promoter (1991) (18)
Distinct subcellular targeting of fluorescent nicotinic α3β4 and serotoninergic 5‐HT3A receptors in hippocampal neurons (2004) (18)
Functional Organization and Conformational Dynamics of the Nicotinic Receptor (2008) (18)
Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein (2014) (18)
Do Nicotinic Receptors Modulate High-Order Cognitive Processing? (2020) (18)
Activity regulates the levels of acetylcholine receptor a-subunit mRNA in cultured chicken myotubes ( allelic variants / restriction fragment-length polymorphism / control of mRNA accumulation / denervation hypersensitivity ) (18)
Nicotinic acetylcholine receptor‐subunit mRNAs in the mouse superior cervical ganglion are regulated by development but not by deletion of distinct subunit genes (2008) (18)
In vitro excitation of purified membrane fragments by cholinergic agonists (1971) (18)
Brain activation by short-term nicotine exposure in anesthetized wild-type and beta2-nicotinic receptors knockout mice: a BOLD fMRI study (2009) (18)
Conservation of the kinetic and allosteric properties of the acetylcholine receptor in its Na cholate soluble 9 S form : effect of lipids. (1980) (18)
Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model. (1997) (17)
Biased Allostery. (2016) (17)
Regulation of an acetylcholine receptor LacZ transgene by muscle innervation. (1992) (17)
Regional differential effects of chronic nicotine on brain &agr;4-containing and &agr;6-containing receptors (2008) (17)
The good, the true, & the beautiful : a neuronal approach (2012) (17)
Proactive epigenesis and ethical innovation (2016) (17)
Nicotinic receptors and brain plasticity. (1996) (17)
In Vitro excitation of purified membrane fragments by cholinergic agonists (1971) (17)
Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice (2004) (17)
Protein differences associated with the absence of granule cells in the cerebella from the mutant weaver mouse and from X‐irradiated rat (1974) (17)
Intermediate closed state for glycine receptor function revealed by cysteine cross-linking (2013) (17)
Variation and selection in neural function. (1997) (17)
A single (−)-nicotine injection causes change with a time delay in the affinity of striatal D2 receptors for antagonist, but not for agonist, nor in the D2 receptor mRNA levels in the rat substantia nigra (1995) (16)
Denervation of mouse skeletal muscle differentially affects the expression of the jun and fos proto-oncogenes. (1990) (16)
Activity-dependent regulation of gene expression in muscle and neuronal cells (2008) (16)
Functional architecture of the nicotinic acetylcholine receptor (1994) (16)
On the Nature of Allosteric Transitions: A Plausible Model (1978) (16)
Synthesis and pharmacological activity on Electrophorus electricus electroplaque of photoaffinity labelling derivatives of the non‐competitive blockers di‐ and tri‐methisoquin (1980) (16)
Allosteric proteins: from regulatory enzymes to receptors--personal recollections. (1993) (16)
Stabilization of the high affinity state of the membrane‐bound acetylcholine receptor from Torpedo marmorata by noncompetitive blockers (1981) (16)
Photoactivatable agonist of the nicotinic acetylcholine receptor: potential probe to characterize the structural transitions of the acetylcholine binding site in different states of the receptor. (1992) (16)
Sevoflurane Anesthesia Alters Exploratory and Anxiety-like Behavior in Mice Lacking the β2 Nicotinic Acetylcholine Receptor Subunit (2008) (16)
Pulmonary and Renal Pathology 7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation (2009) (16)
On the association of tyrocidine with acetylcholinesterase. (1969) (16)
Interaction of a spin-labeled long chain acylcholine with the cholinergic receptor protein in its membrane environment. (1975) (16)
Complete nucleotide sequence of Torpedo marmorata mRNA coding for the 43,000-dalton nu 2 protein: muscle-specific creatine kinase. (1984) (16)
Evidence for a skeleton in acetylcholine receptor‐rich membranes from Torpedo marmorata electric organ (1982) (15)
Functional properties of the purified cholinergic receptor protein from Electrophorus electricus. (1973) (15)
Allosteric properties of the acetylcholine receptor protein from Torpedo marmorata. (1983) (15)
Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology. (2011) (15)
Synaptic Epigenesis and the Evolution of Higher Brain Functions (2012) (14)
Mutational Analysis of the Charge Selectivity Filter of the a 7 Nicotinic Acetylcholine Receptor receptor from Torpedo electric organ with channel blockers (1999) (14)
Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor (2007) (14)
A single gene codes for the nicotinic acetylcholine receptor alpha‐subunit in Torpedo marmorata: structural and developmental implications. (1984) (14)
Deciding between conflicting motivations: What mice make of their prefrontal cortex (2012) (13)
Structural Identification of the Nicotinic Receptor Ion Channel (2018) (13)
Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors (2007) (13)
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Transcription in neuromuscular junction formation: Who turns on whom? (2003) (13)
Localization of α‐bungarotoxin binding sites on outer hair cells from the guinea‐pig cochlea (1989) (12)
Nicotinic receptor: a prototype of allosteric ligand-gated ion channels and its possible implications in epilepsy. (1999) (12)
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Regional changes in the cholinergic system in mice lacking monoamine oxidase A (2009) (12)
A Raman spectroscopic study of acetylcholine receptor-rich membranes from Torpedo marmorata. Interaction of the receptor with carbamylcholine and (+)-tubocurarine. (1993) (11)
The Glycine Receptor Allosteric Ligands Library (GRALL) (2020) (11)
Electrical activity regulates AChR gene expression via JNK, PKCζ and Sp1 in skeletal chick muscle (2001) (11)
Coexistence of neuronal messengers and molecular selection. (1986) (11)
Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules. (2016) (11)
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The acetylcholine receptor: a model of an allosteric membrane protein mediating intercellular communication. (1992) (11)
Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. (1990) (10)
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Developmental changes in the subcellular distribution of the 43K (v1) polypeptides in Torpedo marmorata electrocyte: support for a role in acetylcholine receptor stabilization. (1991) (9)
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Allosteric effects of diprobutine on acetylcholine receptors. (1985) (8)
In situ localization of soluble and filamentous actin in Torpedo marmorata electrocyte (1987) (8)
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Ivermectin as a potential treatment for COVID-19? (2021) (8)
Occurrence of neuropeptide K-like immunoreactivity in ventral horn cells of the chicken spinal cord during development (1991) (8)
The noncompetitive blocker [(3)H]chlorpromazine labels segment M2 but not segment M1 of the nicotinic acetylcholine receptor alpha-subunit. (1989) (8)
[ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHESIZED L-THREONINE DEAMINASE. VI. GENERAL DISCUSSION]. (1965) (8)
Large-Scale Purification in Its Membrane-Bound of the Acetylcholine-Receptor Protein and Detergent -Ext ract ed Forms from Torpedo marmorata Electric Organ (1977) (8)
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An acetylcholine receptor α-subunit promoter confers intrathymic expression in transgenic mice (1994) (7)
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Acetylcholine receptor expression in primary cultures of embryonic chick myotubes--I. Discoordinate regulation of alpha-, gamma- and delta-subunit gene expression by calcitonin gene-related peptide and by muscle electrical activity. (1989) (6)
The Neuroscience of Art: A Research Program for the Next Decade? (2011) (6)
Changes in extrinsic fluorescence intensity of the electroplax membrane during electrical excitation (1971) (6)
About the changes of internal ionic concentration in the isolated electroplax during chemical excitation. (1970) (6)
Functional Organization of the Acetylcholine Receptor: A Model of Ligand Gated Ion Channel (1988) (6)
Artistic Creativity (2019) (5)
[Demonstration of the excitation by cholinergic agonists from fractions of purified membranes, in vitro]. (1970) (5)
Interaction of modified neurotoxins fromNaja nigricollis with the nicotinic acetylcholine receptor fromTorpedo marmorata A Raman spectroscopy study (1991) (5)
[ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHESIZED L-THREONINE DEAMINASE. VI. GENERAL DISCUSSION]. (1965) (5)
Beauty in the brain: for a neuroscience of art (2012) (5)
Regulation of Acetylcholine Receptor Biosynthesis During Motor Endplate Morphogenesis (1989) (5)
The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction (2020) (5)
[ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHESIZED L-THREONINE DEAMINASE. V. THE ALLOSTERIC TRANSITION]. (1965) (5)
[Preferential affinity of acetylcholine receptor protein for certain lipids studied using monolayer cultures]. (1977) (5)
Differential Susceptibility of Young and Old Rat Neuromuscular Junctions to Antibody‐mediated AChR Degradation in Experimental Autoimmune Myasthenia Gravis (1998) (4)
Myoblast therapy. (1992) (4)
The section freeze-substitution technique. II. Application to localization of enzymes and other chemicals. (1961) (4)
Functional organization of the nicotinic acetylcholine receptor (1991) (4)
[A biochemical mechanism for the epigenesis of the neuromuscular junction]. (1981) (4)
Nicotinic receptors: From protein allostery to computational neuropharmacology. (2021) (4)
The Newborn Brain: Reflections on the origins of the human brain (2010) (4)
Knockout mice as animal models for studying nicotinic acetylcholine receptor function (2000) (4)
Functional properties of the acetylcholine receptor protein (1980) (4)
&agr;7 and &bgr;2* nicotinic receptors control monoamine-mediated locomotor response (2010) (4)
Studies of tubocurarine labelled with iodine or tritium. (1973) (4)
The Good, the True, and the Beautiful (2017) (4)
Group Report : Neocortical Microcircuits UPs and DOWNs in Cortical Computation (2006) (4)
Partners make patterns in morphogenesis (1994) (4)
A Ph. D. WITH JACQUES MONOD: PREHISTORY OF ALLOSTERIC PROTEINS (2003) (3)
Signal transduction across cellular membranes. (1982) (3)
Nicotine Paradoxical allosteric effects of competitive inhibitors on neuronal a 7 nicotinic receptor mutants (1997) (3)
Conformational Dynamics in a Nicotinic Receptor Homologue Probed by Simulations (2011) (3)
[Relative orientation of the two oligomers composing the heavy form of the acetylcholine receptor from Torpedo marmorata]. (1982) (3)
Allosteric proteins: From regulatory enzymes to receptors (2006) (3)
Biology of Learning in Nonhuman Mammals (1984) (3)
[ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHETIC L-THREONINE DEAMINASE. 3. INTERPRETATION OF THE INHIBITORY EFFECT OF L-ISOLEUCINE: STERIC HINDRANCE OR ALLOSTERIC EFFECT]. (1964) (3)
David Nachmansohn (1899-1983): a pioneer of neurochemistry (1985) (3)
Networks of formal neurons and memory palimpsests (Erratum) (1986) (3)
[Selective stabilization of neuronal representations by resonance between spontaneous prerepresentations of the cerebral network and percepts evoked by interaction with the outside world]. (1984) (3)
Signal transduction across cellular membranes. (1982) (3)
[On the biochemical expression of genetic determinants of Escherichia coli introduced to Salmonella typhimurium]. (1960) (3)
Electrophysiology of Neuronal Nicotinic Receptors in the CNS (1995) (3)
Molecular genetics of Torpedo marmorata acetylcholine receptor. (1984) (3)
[The high affinity binding site for chlorpromazine is present only as a single copy per cholinergic receptor molecule and is shared by four polypeptide chains]. (1982) (3)
[Effect of L-threonine and L-isoleucine analogs on L-threonine desaminase]. (1962) (3)
Computer simulation in brain science: Neural networks: learning and forgetting (1988) (3)
Molecular biology of acetylcholine receptor long-term evolution during motor end-plate morphogenesis. (1989) (3)
Regulation of Acetylcholine Receptor Gene Expression During Development of the Neuromuscular Junction (1989) (3)
On the biochemical expression of genetic determinants of Escherichia coli introduced to Salmonella typhimurium (1960) (2)
Why intracranial electrical stimulation of the human brain suggests an essential role for prefrontal cortex in conscious processing: a commentary on Raccah et al. (2021) (2)
[On the properties of biosynthetic L-threonine desaminase of a mutant of E. coli K 12]. (1966) (2)
Abnormal response of dopaminergic neurons to nicotine without perturbation of nicotinic receptors in αCGRP knock-out mice (2008) (2)
Docking of alpha-cobratoxin suggests a basal conformation of the nicotinic receptor. (2007) (2)
THE VISIT OF PROFESSOR CHEN-YUAN LEE TO THE PASTEUR INSTITUTE IN 1970 AND THE USE OF A SNAKE VENOM TOXIN TO IDENTIFY THE ACETYLCHOLINE RECEPTOR PROTEIN (2005) (2)
Complete nucleotide sequence of Torpedo marmorata mRNA coding for the 43 , 000-dalton v 2 protein : Muscle-specific creatine kinase ( cDNA cloning / hybrid-selected translation / oligonucleotide-specific primer extension ) JRR 6 (2)
[A theory of electric excitation of biological membranes]. (1970) (2)
Phorbol esters inhibit the activity of the chicken acetylcholine receptor alpha-subunit gene promoter. Role of myogenic regulators. (1991) (2)
Identification of two critical residues within the Cys-loop sequence that determine fast-gating kinetics in a pentameric ligand-gated ion channel (2006) (2)
INVITRO STUDIES WITH THE CHOLINERGIC RECEPTOR OF THE EEL ELECTROPLAX (1971) (2)
Tertiary Structure of the Nicotinic Acetylcholine Receptor Probed by Photolabeling and Protein Chemistry (1986) (2)
Two Cultures and Our Encyclopaedic Brain (2018) (2)
[ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHETIC L-THREONINE DEAMINASE. II. KINETICS OF ACTION OF BIOSYNTHETIC L-THREONINE DEAMINASE WITH RESPECT TO THE NATURAL SUBSTRATE AND INHIBITOR]. (1964) (2)
Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex (2021) (2)
Localization of alpha-bungarotoxin binding sites on outer hair cells from the guinea-pig cochlea. (1989) (2)
Attention‐deficit/hyperactivity disorder: A plausible mouse model? (2006) (2)
The Epigenetic Variability of Memory (2010) (2)
[ON THE ALLOSTERIC PROPERTIES OF L-THREONINE DEAMINASE. I. METHODS OF STUDYING BIOSYNTHETIC L-THREONINE DEAMINASE]. (1964) (2)
The Molecular Biology of Consciousness (2007) (2)
Response by the authors (2017) (2)
S.12.01 Neuronal nicotinic receptor subtypes: Perspective on roles in health and disease (2003) (1)
Dynamic Cellular Cartography: Mapping the Local Determinants of Oligodendrocyte Transcription Factor 2 (OLIG2) Function in Live Cells Using Massively Parallel Fluorescence Correlation Spectroscopy Integrated with Fluorescence Lifetime Imaging Microscopy (mpFCS/FLIM) (2021) (1)
Selectionist mechanisms: A framework for interactionism (1988) (1)
Learning and Selection in the Nervous System (1988) (1)
215 Perinatal Nicotine Exposure Disrupts Breathing Rhythm by Interfering with O2 (NOT CO2) – Sensitive Respiratory Stabilizing Mechanisms. (2005) (1)
Faculty of 1000 evaluation for Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. (2011) (1)
Toward a Neuroscience of the Capable Person: Unity; Diversity and Oneself-as-another (2008) (1)
[ON THE ALLOSTERIC OF BIOSYNTHESIZED L-THREONINE DEAMINASE. IV. THE DESENSITIZATION PHENOMENON]. (1965) (1)
25 Critical elements determining diversity in agonist binding and desensitization of neuronal nAChR (1998) (1)
Some Principles of Neuronal Regulation at the Postsynaptic Level (1979) (1)
Academics in Chile (1974) (1)
[ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHESIZED L-THREONINE DEAMINASE. V. THE ALLOSTERIC TRANSITION]. (1965) (1)
Communications cellulaires (1975-2006) (2018) (1)
Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway (2022) (1)
European brain research (1994) (1)
[Structural transitions of the Torpedo cholinergic receptor in its membrane state as demonstrated by a fluorescent local anesthetic: quinacrine]. (1975) (1)
Heterogeneity and selective targeting of nAChR subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus. Identification of a new native nAChR subtype α3β2(α 5 or β 3) enriched in retinocollicular afferents . (2005) (1)
[Reflections of a neurobiologist on the origin of ethics]. (1998) (1)
The multiple phenotypes of allosteric receptor mutants (nicotinic acetylcholine receptoryglycine receptoryion channelyneurotransmitter site) (1996) (1)
Academics in Chile (1974) (1)
The European Future Technologies Conference and Exhibition 2011 Introducing the Human Brain Project (2011) (1)
Molecular basis of nerve activity : proceedings of the International Symposium in Memory of David Nachmansohn (1899-1983), Berlin (West) Germany, October 11-13, 1984 (1985) (1)
SOME FUNCTIONAL PROPERTIES OF THE CHOLINERGIC RECEPTOR PROTEIN FROM FISH ELECTRIC ORGAN IN ITS PURIFIED, MEMBRANE-BOUND AND REASSOCIATED STATES (1976) (1)
[Perfecting an apparatus allowing to measure changes of extrinsic fluorescence intensit y associated with electric excitation of electroplaque isolated from gymnotus]. (1970) (1)
[Some physical properties of the acetylcholine protein receptor studied with a radioactive neurotoxin]. (1971) (1)
13-1 Brain nicotinic receptors: functional organization and regulation, therapeutic implications (1997) (1)
Creativity and Neuroscience (1996) (1)
The Newborn Brain: On the emergence of consciousness (2010) (1)
Differential mechanisms underlie trace and delay conditioning in Drosophila (2022) (1)
Faculty Opinions recommendation of The structural basis of agonist-induced activation in constitutively active rhodopsin. (2011) (1)
Cytochemical and ultrastructural changes in aflatoxin-induced injury to rat liver cells. (1984) (1)
Induction of acetylcholine receptor a-subunit gene expression in chicken myotubes by blocking electrical activity requires ongoing protein synthesis ( turnover of protein factors / endplate development / elementary learning ) (1)
Topographical Analysis of the Torpedo Marmorata Acetylcholine Receptor by Energy Transfer Photoaffinity Labeling Using Aryldiazonium Derivatives (1989) (1)
Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during nevelty exploration of a familiar environment. (2011) (1)
Comparison of embryonic and adult torpedo acetylcholine receptor by sedimentation characteristics and antigenicity (1984) (1)
Molecular Mechanisms of Synaptic Transmission and Its Regulation: Application to Models of Cognitive Functions (1996) (1)
Protein dynamics and the allosteric transitions of pentameric receptor channels (2014) (1)
Epigenesis, synapse selection, cultural imprints, and brain development: from molecules to cognition (2022) (1)
Effects of ionic forces and curarizing agents on the acetylcholine esterase properties of the electric tissue of Torpedo marmorata (1966) (1)
Cholinergic receptors in Electrophorus. (1973) (1)
[ON THE ALLOSTERIC OF BIOSYNTHESIZED L-THREONINE DEAMINASE. IV. THE DESENSITIZATION PHENOMENON]. (1965) (1)
Functional Organization of the Polypeptide Chains of the Nicotinic Acetylcholine Receptor (1987) (0)
control of expression in transfected cells. confers tissue specificity and developmental acetylcholine receptor alpha-subunit gene A 5'-flanking region of the chicken (2013) (0)
On the biochemical expression of genetical determinants of E. coli introduced into S. typhimurium. (1960) (0)
Drug Use and Abuse (2017) (0)
Faculty Opinions recommendation of Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential. (2021) (0)
[Effects of chronic medullary stimulation on the total number of sites of acetylcholinesterase activity of the posterior latissimus dorsi muscle of chick embryo]. (1981) (0)
La neuroscience : un univers en expansion (2002) (0)
Note on “Protein dynamics and the allosteric transitions of pentameric receptor channels” by Jean-Pierre Changeux (2014) (0)
Molecular genetics approach to the nicotinic acetylcholine receptor (AchR) (1985) (0)
An H‐bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors (2013) (0)
An acetylcholine receptor α subunit promoter confers intrathymic expression in transgenic mice (1998) (0)
Structural Basis for Allosteric Transitions in the GLIC Pentameric Proton-Gated Ion Channel (2014) (0)
Book Reviews (2002) (0)
Cover Picture: Monitoring Protein Interactions in the Living Cell Through the Fluorescence Decays of the Cyan Fluorescent Protein (ChemPhysChem 7/2006) (2006) (0)
Reflections of a neuroscientist on the origins of ethics (1999) (0)
A tribute to Eddy Fischer (April 6, 1920–August 27, 2021): Passionate biochemist and mentor (2022) (0)
Inhibitory control of synaptic signals preceding motor action in mouse frontal cortex (2021) (0)
Faculty Opinions recommendation of An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. (2016) (0)
Cholinergic (Nicotinic) Receptor and Lipids: Lipid Composition of Receptor-Rich Membranes Purified from Torpedo murmorata Electric Organ and Interaction of the Purified Receptor Protein with Monolayers of Pure Lipids (1979) (0)
[Preservation of the allosteric properties of the protein receptor for acetylcholine in detergent solution without addition of lipids]. (1981) (0)
John Paul Merlie (1945–1995) (1995) (0)
From bacteria to brain: Structure and pharmacology of neurotransmitter receptor channels (2014) (0)
Monoclonal antibody directed against the 43 000 dalton v1 polypeptide from Torpedo marmorata electric organ. (1984) (0)
Muscle-specific expression oftheacetylcholine receptor a-subunit gene requires bothpositive andnegative interactions betweenmyogenic factors, SpiandGBF factors (1993) (0)
SubunitCompositionofFunctionalNicotinicReceptorsin DopaminergicNeuronsInvestigatedwithKnock-OutMice (2003) (0)
MOLECULAR INTERACTIONS BETWEEN THE MAJOR PROTEINS OF THE POSTSYNAPTIC DOMAIN IN TORPEDO MARMORATA ELECTROMOTOR SYNAPSE (1985) (0)
Regulation of FGF-2 gene by nicotinic receptors and its intracellular signaling mechanism in the rat brain (2002) (0)
(acetylcholine ionophore/quinacrine fluorescence/subunit inter (2016) (0)
Faculty Opinions recommendation of Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. (2011) (0)
Faculty of 1000 evaluation for The gating cycle of a K+ channel at atomic resolution. (2018) (0)
X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 6-(4-Methoxyphenyl)-N4-octylpyrimidine-2,4-diamine (2014) (0)
[Effect of local anesthetics on the binding properties of cholinergic receptors of the torpedo]. (1974) (0)
Editorial Board (1995) (0)
Production and characterization of a monoclonal antibody directed (1999) (0)
[Effect of cholinergic agents and local anesthetics on the kinetics of binding of tritiated toxin of Naja nigricollis to the cholinergic receptor]. (1972) (0)
S.16.05 Animal models of cognitive flexibility (2009) (0)
Asymmetrical Distribution of Membrane-bound Cytoskeleton Proteins at the Innervated and Non-innervated Membrane Domains in Torpedo Electrocytes (1986) (0)
[A theory for sodium ion transport during electric stimulation]. (1972) (0)
Subject Index Vol. 2, 1979 (1979) (0)
The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms (2013) (0)
Jean-Pierre Changeux: allostery as neuro-enlightenment. (2009) (0)
The Torpedo marmorate electrocyte: Developmental changes in the subcellular distribution of the 43K (ν1) protein suggest a role for the 43K protein in the stabilization of acetylcholine receptors (1991) (0)
In vivo and in vitro analysis of electrical activity-dependent expression of muscle acetylcholine receptor genes using adenovirus (E box/myogenic factor/muscle denervation/neuromuscular junction/gene transfer) (2016) (0)
Identification of cDNA clones coding for Torpedo marmorata acetylcholine receptor subunits and a model for the transmerabrane organization (1983) (0)
[In vitro demonstration of drug desensitization of the acetylcholine receptor with fragments of excitable membrane from the torpedo fish]. (1974) (0)
A system biology approach for modeling the brain: from genes to consciousness (2018) (0)
Faculty Opinions recommendation of Allosteric Modulator Discovery: From Serendipity to Structure-Based Design. (2019) (0)
A MORPHOLOGICAL STUDY OF THE CHOLINERGIC RECEPTOR PROTEIN FROM TORPEDO MARMORATA IN ITS MEMBRANE ENVIRONMENT AND TN ITS DETERGENT-EXTRACTED PURIFIED FORM JEAN CARTAUD (2005) (0)
Structure and function of nicotinic receptors (1994) (0)
Molecular Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice (2010) (0)
Reviewer list for 2005 (2005) (0)
Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice (2011) (0)
Nicotinic receptors subunits and nicotine reinforcement investigated with knock-out mice (1998) (0)
non-human mutant mammal for expression of the alpha6 subunit of the nicotinic acetylcholine receptor and use for screening substances that interact with receptor (2000) (0)
(rapid kinetics/channel blocker/activation/desensitization) (2016) (0)
Proteomic Profiling of Interactions Comprising the Beta 2 Subunit of the Nicotine Receptor Using MALDI‐TOF MS Analysis (2007) (0)
[The chemistry of cerebral communications]. (1993) (0)
Biophysical Perspective Biased Allostery (2016) (0)
Reflections of a neurobiologist on the origin of ethics (1998) (0)
The Nicotinic Acetylcholine Receptor: A Member of the Superfamily of Ligand-Gated Ion Channels (1991) (0)
CGRP and the development of the motor endplate (1991) (0)
Thanks to our guest reviewers (1990) (0)
[Rapid changes in the intensity of fluorescence observed in the presence of cholinergic agonists with Torpedo marmorata membrane fragments rich in cholinergic receptors and labelled with quinacrine]. (1976) (0)
Conformational Changes of the Cholinergic Receptor Protein from Torpedo Marmorata as Revealed by Quinacrine Fluorescence (1976) (0)
[The 2000 years]. (2015) (0)
Faculty Opinions recommendation of New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels. (2011) (0)
Mixed irreversible MAOIs trigger locomotor response to nicotine in mice : Effects in mice knockout for the 2, 4,6 or 7 nAchR subunit. (2006) (0)
Allosteric Sites and Conformational Transitions of the Acetylcholine Receptor: Models for Short-term Regulation of Receptor Response (1987) (0)
Faculty Opinions recommendation of Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. (2015) (0)
[Comparative action of chronic injection of alpha toxin from Naja nigricolis and of botulinum toxin A on the development of chick embryo dorsal and ventral spinal roots]. (1976) (0)
1135 – PROP ERTIES OF THE CHOLINERGIC RECEPTOR PROTEIN FROM FISH ELECTRIC ORGAN IN ITS PURIFIED AND MEMBRANE BOUND FORMS (1977) (0)
Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata (1975) (0)
Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC (2011) (0)
Allosteric Receptors after 30 Years Review the presence of several identical subunits assembled (1998) (0)
Nicotinic Acetylcholine Receptor Subtypes Dorsal Root Ganglion Neurons Express Multiple (2015) (0)
Nicotinic receptors control dopamine-mediated locomotor behaviors (2007) (0)
K12 E. coli Deaminase from Allosteric Interactions on Biosynthetic L-threonine (2012) (0)
Notice of retraction. (2018) (0)
[Local anesthetic effect of several lipid-soluble compounds on the carbamylcholine response of the Electrophorus electroplax and the acetylcholine binding to the cholinergic receptor of Torpedo]. (1975) (0)
Molecular and cellular interactions underlying higher brain functions : proceedings of the 9th Meeting of the International Neurobiology Society, held at the Abbaye royale de Fontevrault (France), on September 1-4 1981 (1983) (0)
The postsynaptic domain in Torpedo marmorata electric organ: molecular architecture and stabilization mechanisms. (1984) (0)
α‐Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between 06 β4 and 0:6 β2 nicotinic acetylcholine receptors and blocks nicotine‐stimulated norepinephrine release (2010) (0)
Faculty Opinions recommendation of The oligomeric state sets GABA(B) receptor signalling efficacy. (2011) (0)
Beta2-containing nicotinic receptor of the ventral tegmental area crucial for acquisition of nicotine self-administration but not for nicotine withdrawal syndrome (2005) (0)
Review Targeting Transcription to the Neuromuscular Synapse (2001) (0)
Differential susceptibility of young and aged rat muscle to antibody-mediated AChR degradation in experimental autoimmune myasthenia gravis (EAMG) (1997) (0)
Evidnece for degradation of the acetylcholine (nicotinic) receptor in skeletal muscle during the development of the chick embryo. (1977) (0)
Jean-Pierre Changeux: allostery as neuro-enlightenment. (2009) (0)
Session III: Biological Sciences — Biodiversity — Sustainability (2010) (0)
C URRENT OPINION Conscious processing: implications for general anesthesia (2012) (0)
Single Molecule Motion Map of GLIC by Diffracted X-Ray Tracking (2015) (0)
of Biological Chemistry concept of allosteric interaction and its consequences for the chemistry of the brain.” (2013) (0)
[Study by a rapid mixing method of the interaction between a fluorescent cholinergic agonist and membrane fragments rich in cholinergic receptors from Torpedo marmorata]. (1977) (0)
Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC (2011) (0)
International Workshop on Structural and Functional Aspects of the Cholinergic Synapse Held in Jerusalem, Israel on 30 August-4 September 1987 (1987) (0)
Spin glass model of learning by selection ( Darwinism / categorizaton / Hebb synapse (2003) (0)
Faculty of 1000 evaluation for A tale of two repressors. (2011) (0)
Chronic nicotine administration restores genetic-induced cognitive defects via recovery of endogenous cholinergic activity (2005) (0)
How does complexity lead to apparently simple function (1999) (0)
Cholinergic receptors in Electrophorus. (1973) (0)
Interaction of a fluorescent ligand with the protein receptor of acetylcholine present in Torpedo marmorata membrane fragments (1973) (0)
Faculty Opinions recommendation of α3* Nicotinic acetylcholine receptors in the habenula-interpeduncular nucleus circuit regulate nicotine intake. (2021) (0)
Faculty Opinions recommendation of Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating. (2018) (0)
[Interaction of a fluorescent ligand with the protein receptor of acetylcholine present in Torpedo marmorata membrane fragments]. (1973) (0)
The chemistry of cerebral communications (1993) (0)
CrucialRoleof4and6NicotinicAcetylcholineReceptor SubunitsfromVentralTegmentalAreainSystemicNicotine Self-Administration (2008) (0)
Faculty Opinions recommendation of Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor. (2020) (0)
23 Characterization of mice lacking the nicotinic receptor α4 subunit (1998) (0)
Allosteric transitions oftheacetylcholine receptor probedatthe aminoacidlevel withaphotolabile cholinergic ligand (1991) (0)
A role for neuronal nicotinic receptors in ADHD like behaviors (2009) (0)
X-Ray Structures of the Open and Resting Forms of the Same Bacterial Pentameric Ligand-Gated Ion Channel (2014) (0)
552 Nicotinic receptors (nAChR) in the brain: Gene expression and contribution to learning and aging processes (1996) (0)
Faculty of 1000 evaluation for Allostery and cooperativity revisited. (2011) (0)
Faculty Opinions recommendation of A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase. (2011) (0)
IDENTIFICATION OF CRITICAL DNA SEQUENCES INVOLVED IN THE OVEREXPRESSION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR (nAChR) [Greek small leter alpha] SUBUNIT IN THE DENERVATED MUSCLE (1998) (0)
Faculty Opinions recommendation of Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107. (0)
STUDIES ON THE MOLECULAR MECHANISM OF THE RESPONSE OF AN EXCITABLE MEMBRANE TO CHOLINERGIC AGENTS (1971) (0)
Faculty Opinions recommendation of Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. (2011) (0)
Art et Science - Jean Pierre Changeux (2007) (0)
Multilevel development of cognitive abilities in an artificial neural network (2022) (0)
Identification ofan extracellular motif involved in thebinding ofguanine nucleotides bya glutamate (1996) (0)
L-Threonine Deaminase by L-Isoleucine The Feedback Control Mechanism of Biosynthetic (2012) (0)
Publisher Correction: Differential mechanisms underlie trace and delay conditioning in Drosophila (2022) (0)
rmic polypeptide thymopoietin ic acetylcholine receptor (2016) (0)
Developmental studies of the 43kD (ν1) proteins in Torpedo marmorata electrocyte (1989) (0)
INTERACTIONS BETWEEN VULNERABILITY TO DEVELOP DRUG INTAKE AND RELAPSE TO DRUG TAKING (1996) (0)
Faculty Opinions recommendation of Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1. (2020) (0)
A Neurobiological Theory of Aesthetic Experience and Creativity (2017) (0)
Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli. (2015) (0)
Book Reviews (2020) (0)
Localization of the chlorpromazine binding site on the sequence of acetylcholine receptor delta subunit from torpedo marmorata (1985) (0)
Faculty of 1000 evaluation for Crystal structures of human glyrα3 bound to ivermectin. (2018) (0)
7 Neural development: Genetics and epigenesis (1998) (0)
Book reviews (2004) (0)
Developmental Regulation of Acetylcholinesterase mRNA in the Mouse Diaphragm (1995) (0)
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation (2022) (0)
An open-pore structure of a bacterial pentameric ligand-gated ion channel (2008) (0)
Tritium labelling of the alpha-neurotoxin of Naja nigricollis. (1971) (0)
Contents Vol. 2, 1979 (1979) (0)
Nicotinic Acetylcholine Receptor Functions in the CNS Investigated with a Novel Method of Stereotaxic Gene Re‐expression in Knockout Mice (2008) (0)
Paleoanthropology of cognition: an overview on Hominins brain evolution. (2022) (0)
1 p A Necessary Encounter Knowledge and Wisdom (2000) (0)
[Effects of ionic forces and curarizing agents on the acetylcholine esterase properties of the electric tissue of Torpedo marmorata]. (1966) (0)
Jean-Pierre Changeux and Paul Ricoeur : What Makes Us Think ? (2000) (0)
Reviewer List for 2004 (2004) (0)
Scanning‐Free functional Fluorescence Microscopy Imaging Toward Spatial Mapping of Biomolecular Information in Live Cell (2022) (0)
Faculty Opinions recommendation of The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel. (2016) (0)
5 An antibody specific for the neuronal nicotinic acetylcholine receptor alpha 4 subunit: High levels of expression in monoaminergic neurons (1998) (0)
Allosteric Transition and Pharmacological Modulation of Pentameric Channel-Receptors: The Case of General Anesthetics (2012) (0)
35 Nicotinic receptors (nAChR) in the brain : Gene expression and contribution to learning and aging processes (1996) (0)
Faculty Opinions recommendation of T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism for allosteric control. (2011) (0)
1P218 PH dependent 3D Motion Maps of GLIC from X-ray Single Molecule Observations(13C. Biological & Artificial membrane: Excitation & Channels,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) (2014) (0)
Faculty Opinions recommendation of Unveiling the timescale of the R-T transition in human hemoglobin. (2011) (0)
Books/Livres (2016) (0)
Neuronal, trophic and endocrine effects of nicotine (1994) (0)
Is the acetylcholine receptor targeted to the subsynaptic membrane in innervated muscle fiber (1990) (0)
Faculty of 1000 evaluation for Hemoglobin is an honorary enzyme. (2011) (0)
Faculty Opinions recommendation of Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. (2014) (0)
Tolerance of a Transgenic Self Antigen Expressed in the Thymus: Implication for Myasthenia gravis (2000) (0)
The nicotinic receptor-associated 43K protein is a phosphoprotein (1989) (0)
Foreword. Avant-propos (2008) (0)
Correction: Binding of Thymopoietin to the Acetylcholine Receptor (1993) (0)
Louis Pasteur, molecular dissymmetry, therapeutic chemistry and neuropharmacology. (2022) (0)
AT THE AMINO ACID LEVEL (2000) (0)
The resting-state conformation of the GLIC ligand-gated ion channel (2013) (0)
63 Predicted secondary structure of a nicotinic acetylcholine receptor subunit. Incorporation of predicted solvent accessibility and experimental data into a two dimensional representation (1998) (0)
Regulation of the Desensitization of the Acetylcholine Nicotinic Receptor (1990) (0)
X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine (2014) (0)
78Involvement of protein kinases and protein phosphatases in the regulation of acetylcholine receptor gene expression (1998) (0)
Studies on the molecular mechanism of the response of an excitable membrane to cholinergic agents. (1972) (0)
neuron-specifi'c expression in the brain and spinal cord of transgenic mice (2005) (0)

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