Jeffrey M. Drazen

Jeffrey M. Drazen's AcademicInfluence.com Rankings

Jeffrey M. Drazen

Philosophy

#3130

World Rank

#5129

Historical Rank

#1023

USA Rank

Logic

#971

World Rank

#1572

Historical Rank

#326

USA Rank

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Philosophy

Jeffrey M. Drazen's Degrees

Doctorate Medicine Harvard University

Why Is Jeffrey M. Drazen Influential?

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According to Wikipedia, Jeffrey M. Drazen was the editor-in-chief of The New England Journal of Medicine from 2000 to 2019. He currently holds the positions of senior physician at the Brigham and Women’s Hospital, Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, professor of physiology at the Harvard School of Public Health, and adjunct professor of medicine at the Boston University School of Medicine. He is the recipient of honorary degrees from the University of Ferrara, the University of Athens, the University of Modena and the University of Paris-Sud.

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Jeffrey M. Drazen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Global strategy for asthma management and prevention: GINA executive summary (2008) (2982)
Statistics in medicine--reporting of subgroup analyses in clinical trials. (2007) (1220)
The biology of nitrogen oxides in the airways. (1994) (946)
Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. (1993) (846)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2004) (790)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2005) (721)
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. (2010) (687)
A summary of the new GINA strategy: a roadmap to asthma control (2015) (685)
Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet (2002) (671)
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial (2004) (618)
Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. (1994) (608)
Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. (1980) (604)
Significant variability in response to inhaled corticosteroids for persistent asthma. (2002) (601)
Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. (1993) (581)
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment (1999) (578)
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. (2000) (565)
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo (2006) (470)
Treatment of asthma with drugs modifying the leukotriene pathway. (1999) (452)
Correction: Treatment of Asthma with Drugs Modifying the Leukotriene Pathway. (1999) (429)
Active anaphylaxis in IgE-deficient mice (1994) (420)
Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. (1998) (408)
Sorting out the cytokines of asthma (1996) (400)
Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids. (1997) (389)
The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. (1993) (387)
Bronchoconstrictor effects of leukotriene C in humans. (1982) (385)
Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources. (1980) (377)
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. (1990) (375)
Letting the genome out of the bottle--will we get our wish? (2008) (368)
Expired nitric oxide levels during treatment of acute asthma. (1995) (367)
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4 (2002) (362)
The Effect of Inhibition of 5-Lipoxygenase by Zileuton in Mild-to-Moderate Asthma (1993) (344)
Long-Acting β2-Agonist Monotherapy vs Continued Therapy With Inhaled Corticosteroids in Patients With Persistent Asthma: A Randomized Controlled Trial (2001) (343)
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. (1996) (342)
Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. (1997) (333)
Bronchodilator action of inhaled nitric oxide in guinea pigs. (1992) (333)
Mechanotransduction through growth-factor shedding into the extracellular space (2004) (331)
Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. (1998) (331)
Heterogeneity of therapeutic responses in asthma. (2000) (323)
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. (1996) (311)
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. (2004) (310)
Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. (2000) (293)
International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors (2003) (291)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors (2005) (288)
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. (2001) (282)
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice (1995) (281)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2004) (279)
On the mechanism of mucosal folding in normal and asthmatic airways. (1997) (277)
Effects of leukotriene D on the airways in asthma. (1983) (273)
Pulmonary responses to bronchoconstrictor agonists in the mouse. (1988) (269)
Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. (2000) (259)
Systemic effect comparisons of six inhaled corticosteroid preparations. (2002) (244)
Asthma exacerbations during long term β agonist use: influence of β2 adrenoceptor polymorphism (2000) (241)
Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity. (1980) (238)
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. (2005) (229)
The use and misuse of Penh in animal models of lung disease. (2004) (227)
Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors (2016) (227)
Sponsorship, authorship and accountability. (2001) (221)
Leukotrienes and airway responses. (1987) (218)
Contribution of Nitric Oxide Synthases 1, 2, and 3 to Airway Hyperresponsiveness and Inflammation in a Murine Model of Asthma (1999) (216)
The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. (1994) (214)
Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung (1995) (211)
Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. (1993) (208)
Recovery of leukotriene E4 from the urine of patients with airway obstruction. (1992) (199)
Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. (1996) (197)
Clinical trial registration: looking back and moving ahead (2007) (196)
Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. (1996) (194)
COX-2 inhibitors--a lesson in unexpected problems. (2005) (193)
Clinical predictors of health-related quality of life depend on asthma severity. (2001) (192)
Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. (1994) (192)
Transparency in authors’ contributions and responsibilities to promote integrity in scientific publication (2017) (192)
New Guidelines for Statistical Reporting in the Journal. (2019) (191)
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. (2002) (190)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. (2005) (188)
Challenges in the Design and Interpretation of Noninferiority Trials (2017) (185)
Sponsorship, authorship, and accountability. (2001) (184)
Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma. (1999) (182)
Inflammation and airway function in asthma: what you see is not necessarily what you get. (1998) (178)
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7 (2014) (178)
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. (2004) (177)
TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids (2004) (176)
Expression of concern: Bombardier et al., "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis," N Engl J Med 2000;343:1520-8. (2005) (175)
Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma. (1994) (170)
Inflammatory cell distribution within and along asthmatic airways. (1998) (168)
Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. (1994) (167)
5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. (2000) (165)
Characterization of a receptor for C5a anaphylatoxin on human eosinophils. (1989) (163)
Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. (2002) (163)
Evaluation of the Substrate Specificity of Human Mast Cell Tryptase βI and Demonstration of Its Importance in Bacterial Infections of the Lung* (2001) (160)
Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. (2001) (160)
Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature. (1995) (159)
Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. (1983) (156)
Asthma and COPD: Basic Mechanisms and Clinical Management (2002) (154)
Mouse models of airway responsiveness: physiological basis of observed outcomes and analysis of selected examples using these outcome indicators. (1999) (144)
Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2-30 Hz), low tidal volume ventilation. (1981) (141)
Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. (2003) (141)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. (2005) (141)
International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions (2011) (140)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors (2004) (140)
Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. (1984) (138)
Antileukotrienes in the Treatment of Asthma (1997) (138)
Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors (2017) (137)
Chronic effects of mechanical force on airways. (2006) (136)
T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice (1997) (136)
Expired nitric oxide after bronchoprovocation and repeated spirometry in patients with asthma. (1998) (135)
Mast cell activation enhances airway responsiveness to methacholine in the mouse. (1993) (135)
Prioritised research agenda for prevention and control of chronic respiratory diseases (2010) (135)
Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro. (1978) (132)
Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. (1987) (130)
Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. (2002) (130)
Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes (2021) (126)
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. (2003) (125)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2004) (124)
Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors. (2017) (124)
Exhaled nitric oxide in patients with asthma: association with NOS1 genotype. (2000) (122)
Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants. (1998) (120)
Amplification of airway constriction due to liquid filling of airway interstices. (1989) (119)
Eotaxin and impaired lung function in asthma. (1999) (119)
Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig. (1974) (119)
Functional characterization of synthetic leukotriene B and its stereochemical isomers (1981) (117)
Substance P-induced bronchoconstriction in the guinea pig. Enhancement by inhibitors of neutral metalloendopeptidase and angiotensin-converting enzyme. (1988) (117)
Sponsorship, authorship, and accountability (2001) (115)
Ventilation with small tidal volumes. (2002) (115)
Data Sharing. (2016) (113)
Clinical Trial Registration Looking Back and Moving Ahead (2007) (113)
Effect of Polymorphism of the β2-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma (2001) (113)
CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma. (2005) (112)
Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. (1989) (110)
The relaxant properties in guinea pig airways of S-nitrosothiols. (1992) (110)
An experimental study of gas exchange in laminar oscillatory flow (1983) (110)
cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). (1998) (110)
Clinical Trial Registration: A Statement from the International Committee of Medical Journal Editors (2004) (108)
Ebola and quarantine. (2014) (108)
Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene. (2000) (108)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2005) (108)
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. (2001) (107)
Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors. (2016) (106)
Leukotrienes as mediators of airway obstruction. (1998) (104)
Tidal volume and frequency dependence of carbon dioxide elimination by high-frequency ventilation. (1981) (104)
Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. (1999) (104)
Expression of concern reaffirmed. (2006) (103)
Drug-eluting coronary stents--promise and uncertainty. (2007) (102)
Financial associations of authors. (2002) (101)
Pharmacogenetics of asthma. (2002) (100)
Neuropeptide content of lungs from asthmatic and nonasthmatic patients. (1995) (100)
Association of Asthma with β2-Adrenergic Receptor Gene Polymorphism and Cigarette Smoking (2001) (100)
Molecular responses of rat tracheal epithelial cells to transmembrane pressure. (2000) (99)
Elevated plasma eotaxin levels in patients with acute asthma. (1999) (99)
Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo. (2012) (97)
Leukotriene Modifiers and Churg-Strauss Syndrome (1999) (96)
Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. (2002) (96)
Immunologically induced generation of tetraene and pentaene leukotrienes in the peritoneal cavities of menhaden-fed rats. (1984) (95)
Polymorphism of the β2-Adrenergic Receptor Gene and Desensitization in Human Airway Smooth Muscle (2000) (93)
In vivo demonstration of nonadrenergic inhibitory innervation of the guinea pig trachea. (1980) (93)
Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells. (1996) (92)
Risks of long-acting beta-agonists in achieving asthma control. (2009) (92)
A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma. (2000) (90)
Registry research and medical privacy. (2004) (90)
Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to-moderate asthma. (1995) (90)
Lung inflation during high-frequency ventilation. (1984) (87)
High-frequency ventilation. (1984) (86)
Atropine modification of the pulmonary effects of chemical mediators in the guinea pig. (1975) (85)
Asthma: one hundred years of treatment and onward. (2005) (83)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2004) (82)
Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes (2021) (82)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors (2005) (81)
Nonhomogeneity of lung response to inhaled histamine assessed with alveolar capsules. (1985) (81)
Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects. (1995) (80)
Reduction of allergic airway responses in P-selectin-deficient mice. (1997) (79)
Uniform format for disclosure of competing interests in ICMJE journals. (2010) (79)
Exhaled nitric oxide following repeated spirometry or repeated plethysmography in healthy individuals. (2000) (79)
Uniform format for disclosure of competing interests in ICMJE journals (2009) (79)
The Chitinase-like Protein YKL-40 Is Secreted by Airway Epithelial Cells at Base Line and in Response to Compressive Mechanical Stress* (2010) (78)
Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors (2016) (77)
Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics. (1989) (77)
Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells. (2006) (77)
CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. (1993) (76)
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. (2005) (75)
Sharing individual patient data from clinical trials. (2015) (73)
Why doctors should worry about preemption. (2008) (72)
Contractile activities of structural analogs of leukotrienes C and D: role of the polar substituents. (1981) (71)
Differential effects of a partially purified preparation of slow-reacting substance of anaphylaxis on guinea pig tracheal spirals and parenchymal strips. (1979) (71)
Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs. (1990) (71)
Univariate and multivariate family‐based association analysis of the IL‐13 ARG130GLN polymorphism in the Childhood Asthma Management program (2002) (69)
Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. (1998) (69)
A glimpse of the next 100 years in medicine. (2012) (69)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors (2004) (69)
Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors (2016) (68)
Informed consent and SUPPORT. (2013) (68)
Data Sharing and the Journal. (2016) (68)
Making Sense of Triple Inhaled Therapy for COPD. (2018) (68)
Uniform format for disclosure of competing interests in ICMJE journals. (2010) (67)
Genetics and pharmacogenetics of the leukotriene pathway. (2009) (67)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. (2005) (66)
Contribution of type I NOS to expired gas NO and bronchial responsiveness in mice. (1997) (64)
Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors (2017) (64)
Acute and chronic effects of allergic airway inflammation on pulmonary nitric oxide production. (1997) (63)
Clinical trial registration--looking back and moving ahead. (2007) (63)
Morphologic correlation of physiologic changes caused by SO2-induced bronchitis in dogs. The role of inflammation. (1984) (62)
Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice. (1998) (62)
Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. (1999) (62)
Effect of nifedipine on constriction of human tracheal strips in vitro (1983) (61)
Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs. (1991) (61)
Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region. (1981) (61)
Is This Clinical Trial Fully Registered? (2005) (61)
Cholesterol lowering and ezetimibe. (2008) (60)
Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. (2003) (60)
High-frequency oscillatory ventilation on shaky ground. (2013) (60)
Awake and informed. (2004) (59)
Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs. (1989) (58)
Indirect assessment of mucosal surface temperatures in the airways: theory and tests. (1987) (58)
Distribution of pulmonary resistance: effects of gas density, viscosity, and flow rate. (1976) (58)
Density gradient study of bronchial mucus aspirates from healthy volunteers (smokers and nonsmokers) and from patients with tracheostomy. (1985) (58)
Inhibition of bronchoconstriction in the guinea pig by a calcium channel blocker, nifedipine. (1982) (58)
Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels. (2003) (58)
Distribution of pulmonary responsiveness to aerosol histamine in dogs. (1978) (57)
H1N1 influenza A disease--information for health professionals. (2009) (57)
Airway wall liquid. Sources and role as an amplifier of bronchoconstriction. (1995) (57)
Photographic measurement of pleural surface motion during lung oscillation. (1985) (57)
Inhalation challenge with sulfidopeptide leukotrienes in human subjects. (1986) (57)
Rosiglitazone--continued uncertainty about safety. (2007) (57)
Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. (2010) (57)
Airway surface liquid thickness as a function of lung volume in small airways of the guinea pig. (1994) (56)
Models of airway hyperresponsiveness (1990) (56)
Substance P-induced histamine release in tracheally perfused guinea pig lungs. (1995) (56)
Rethinking medical training--the critical work ahead. (2002) (56)
Adrenergic influences on histamine-mediated bronchoconstriction in the guinea pig. (1978) (54)
Neuronal NO synthase (NOS1) is a major candidate gene for asthma. (1999) (54)
Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. (1994) (54)
International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor (2004) (53)
Revisiting the commercial-academic interface. (2015) (53)
Variant eotaxin: its effects on the asthma phenotype. (2001) (53)
Clinical trial registration: looking back and moving ahead. (2007) (52)
To protect those who serve. (2000) (52)
Endogenous nitric oxide and allergic bronchial hyperresponsiveness in guinea pigs. (1997) (51)
Case clusters of the severe acute respiratory syndrome. (2003) (51)
Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness. (2004) (50)
The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. (2001) (50)
Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells. (1997) (50)
Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air. (1992) (49)
Genetic variations in the 5-lipoxygenase core promoter. Description and functional implications. (2000) (49)
Ozone-induced airway hyperreactivity in the guinea pig. (1984) (49)
Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. (1993) (49)
H2 receptor mediated inhibition of immediate type hypersensitivity reactions in vivo. (1978) (49)
Human papillomavirus vaccine--opportunity and challenge. (2007) (49)
Full disclosure and the funding of biomedical research. (2008) (49)
Comparative Contractile Responses to Sulfidopeptide Leukotrienes in Normal and Asthmatic Human Subjects (1988) (48)
Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. (2002) (48)
A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. (2003) (47)
Patient organizations and research on rare diseases. (2011) (47)
The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms. (1999) (47)
Ebola--an ongoing crisis. (2014) (46)
Institutions, contracts, and academic freedom. (2002) (45)
SARS--looking back over the first 100 days. (2003) (44)
Sibutramine--another flawed diet pill. (2010) (44)
Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. (2004) (44)
Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide. (2003) (44)
Heterogeneity of leukotriene C4 production by eosinophils from asthmatic and from normal subjects. (1988) (44)
Is this clinical trial fully registered?--A statement from the International Committee of Medical Journal Editors. (2005) (44)
Mucosal folding in biologic vessels. (2002) (43)
Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. (1986) (43)
Beta(2)-adrenoceptor polymorphism and body mass index are associated with adult-onset asthma in sedentary but not active women. (2001) (43)
Interacting genetic loci cause airway hyperresponsiveness. (2005) (42)
High-Value Health Care — A Sustainable Proposition (2013) (42)
An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. (1997) (42)
Peptidase Modulation of Airway Effects of Neuropeptides (1993) (42)
Airway effects of monosodium glutamate in subjects with chronic stable asthma. (1987) (42)
Expiratory flow limitation and dynamic pulmonary hyperinflation during high-frequency ventilation. (1986) (42)
The effect of indomethacin on the contractile response of the guinea‐pig lung parenchymal strip to leukotrienes B4, C4, D4 and E4 (1983) (42)
Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (1999) (42)
Considering recertification. (2010) (41)
Capsaicin-induced release of tachykinins: effects of enzyme inhibitors. (1991) (41)
Methicillin-Resistant Staphylococcus aureus in a Family and Its Pet Cat (2008) (41)
Experimental induction of chronic bronchitis in dogs: effects on airway obstruction and responsiveness. (1982) (40)
Steady flow in a model of human central airways. (1980) (40)
Oculoparalytic Illusion : Visual-Field Dependent Spatial Mislocalizations by Humans Partially Paralyzed with Curare (2006) (40)
Asthma therapy with agents preventing leukotriene synthesis or action. (1999) (40)
The Dangerous Flavors of E-Cigarettes. (2019) (40)
Airway luminal liquid. Sources and role as an amplifier of bronchoconstriction. (1991) (40)
Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. (2004) (39)
Don't mess with the DSMB. (2010) (39)
Asthma treatment guidelines meet the real world. (2011) (39)
β-Agonists and asthma: too much of a good thing? (2003) (39)
Pulmonary response to antigen infusion in the sensitized guinea pig: modification by atropine. (1975) (39)
Finite difference analysis of respiratory heat transfer. (1986) (39)
Sequence variants in the FcεRI alpha chain gene (2002) (38)
Inappropriate advertising of dietary supplements. (2003) (38)
Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs. (2002) (38)
Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle. (2000) (38)
Ezetimibe and cancer--an uncertain association. (2008) (37)
Comparative bronchoconstrictor effects of histamine, leukotriene C, and leukotriene D in normal human volunteers. (1982) (37)
Controlling research trials. (2003) (37)
Effects of interleukin 5-induced pulmonary eosinophilia on airway reactivity in the guinea pig. (1996) (37)
Toward more uniform conflict disclosures--the updated ICMJE conflict of interest reporting form. (2010) (35)
Learning from a Trial Stopped by a Data and Safety Monitoring Board. (2018) (35)
Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung (1997) (35)
Vagal and aerosol histamine interactions on airway responses in dogs. (1978) (34)
Putting the Squeeze on Airway Epithelia. (2015) (34)
A patient with asthma seeks medical advice in 1828, 1928, and 2012. (2012) (34)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2004) (34)
The growth of hospitalists and the changing face of primary care. (2009) (34)
Global Initiative for Asthma (GINA) Strategy 2021 - Executive summary and rationale for key changes. (2021) (34)
Vagal stimulation and aerosol histamine increase hysteresis of lung recoil. (1981) (34)
Clinical trial registration: looking back and moving ahead (2007) (33)
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Time for NIH to lead on data sharing (2020) (33)
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Tidal Volume and Frequency Dependence of Carbon Dioxide Elimination by High-Frequency Ventilation (1982) (27)
Longitudinal elastic wave propagation in pulmonary parenchyma. (1987) (27)
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Physiological basis and interpretation of indices of pulmonary mechanics. (1984) (27)
High-frequency ventilation: a promising new approach to mechanical ventilation. (1981) (26)
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Indomethacin potentiates the pulmonary response to aerosol leukotriene C4 in the guinea pig. (1983) (25)
Treating mild asthma--when are inhaled steroids indicated? (1994) (25)
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Agonist-induced lipoxin A4 generation: Detection by a novel lipoxin A4-ELISA (1993) (24)
"Exhaled nitric oxide during exercise: site of release and modulation by ventilation and blood flow". (1996) (24)
Surgery for emphysema--not for everyone. (2001) (24)
Human lung expresses unique gamma-glutamyl transpeptidase transcripts. (1993) (24)
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Firearm-Related Injury and Death: A U.S. Health Care Crisis in Need of Health Care Professionals (2017) (9)
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A formyl peptide contracts guinea pig lung: role of arachidonic acid metabolites. (1987) (6)
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Revistas con revisión externa (peer review) en la era digital (2010) (3)
Aspirin and Colon Cancer — Targeting Prevention? (2007) (3)
Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors. (2017) (3)
Breathing pattern affects respiratory heat loss but not bronchoconstrictor response in asthma (2007) (3)
Innovations in Correspondence (2003) (3)
Pharmacogenomics of Asthma Treatment (2003) (3)
Presentation of the 2004 Kober Medal to K. Frank Austen. (2004) (2)
DNA sequence variants of the platelet‐derived growth factor A‐chain gene (2001) (2)
Automated detection of single nucleotide polymorphism in beta-2 adrenergic receptor gene using LCx(R). (2001) (2)
Protein sequence of the human neuronal nitric oxide synthase (Type I NOS): an error in the sequence database. (1997) (2)
No child left uncovered. (2007) (2)
The FDA politics and plan B [letter] (2003) (2)
Genetic analysis in the Asthma Clinical Research Network. (2001) (2)
Clinical trial registration: looking back and moving ahead. (2007) (2)
Erratum: The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma (International Archives of Allergy and Immunology (2000) 162 (75-80)) (2012) (2)
Measurements of gas transport in a branching network of tubes during oscillatory flow (1982) (2)
Uniform Format for Disclosure of Competing Interests in ICMJE Journals (2009) (2)
A milestone in tuberculosis control. (2002) (2)
Safer drugs for the American people. (2007) (2)
Open data. (2014) (2)
16 – Cysteinyl Leukotrienes (1998) (2)
Global Initiative for Asthma Strategy 2021 (2022) (2)
Determinants of clinical responses in asthma (2001) (2)
Editorial independence at the BMJ (2004) (2)
Toward more uniform conflict disclosures--the updated ICMJE conflict of interest reporting form. (2010) (2)
Artificial Intelligence in Medicine. (2023) (2)
Compressive Stress Causes an Unjamming Transition and an Epithelial-Mesenchymal Transition in the Airway Epithelium in Asthma. (2016) (2)
-Adrenergic Receptor Gene and Desensitization in Human Airway Smooth Muscle (2000) (2)
Vivek Murthy for Surgeon General. (2014) (2)
The genetics of air pollution (1997) (2)
Clinical Decisions. Mild persistent asthma--polling results. (2007) (2)
Health, Wealth, and the U.S. Senate. (2017) (2)
Bronchodilator Actions of Nitric Oxide and Related Compounds (2000) (2)
Asthma Steroid Pharmacogenetics (2012) (2)
Churg-Strauss syndrome. (1999) (2)
High Frequency Oscillatory Ventilation Using Tidal Volumes Smaller than the Anatomical Dead Space (1983) (2)
The new ICMJE recommendations. (2013) (2)
[Clinical trial registration: a statement from the International Committee of Medical Journal Editors]. (2005) (1)
Contents, Vol. 94, 1991 (1991) (1)
Effect of tidal volume and anesthetic agent on airway responsiveness to histamine. (1986) (1)
What is the Role of Leukotriene Modifiers in the Treatment of Asthma (2008) (1)
NEJM Evidence — A New Journal in the NEJM Group Family (2022) (1)
AIRWAY RESPONSE TO SP AND SP FRAGMENTS IN THE GUINEA - PIG (1988) (1)
NEJM Resident 360. (2016) (1)
Research replication. (2006) (1)
143 Leukotriene E4(LTE4)-induced airway hyperresponsiveness to histamine (1985) (1)
Acute glutathione depletion underlies the early asthmatic response in a guinea pig model of allergic asthma (2001) (1)
Gas Exchange during Combined High and Low Frequency, Low Tidal Volume Ventilation in Dogs1 (1986) (1)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2005) (1)
Severe Acute Respiratory Syndrome (2003) (1)
Slow-reacting substances from rat leukocytes: selective action on the airways, and progress toward elucidation of their structure. (1981) (1)
Discussion Session A: The early life origins of asthma (1998) (1)
ENDORACHEAL TUBE RESISTANCE: THE EFFECTS OF TUBE CURVATURE, TUBE INTERFACES, GAS-LIQUID INTERACTION AND AIRLOW DIRCTION (1992) (1)
heterogeneity of receptors for the C-6-sulfidopeptide leukotrienes (1984) (1)
Chapter 24 – Leukotrienes (2002) (1)
Retraction: Ahimastos AA, Dart AM, Kingwell BA. Angiotensin II blockade in Marfan's syndrome. N Engl J Med 2008;359:1732. (2015) (1)
Uniform format for disclosure of competing interests in ICMJE Journals. (2009) (1)
Data sharing Statements for Clinical Trials: A requirement of the International Committee of Medical Journal Editors. (2017) (1)
Is anybody listening? (2015) (1)
Leukotrienes and immediate hypersensitivity responses. (1985) (1)
Antigen-antibody mediated desensitization of human lung fragments in vitro (1973) (1)
Response to ‘Lapses at the NEJM’ (2006) (1)
Comprar Asthma And Copd: Basic Mechanisms And Clinical Management | Neil Thomson | 9780123740014 | Academic Press (2008) (1)
Your health in the 21st century. Getting all the facts on drugs. (2005) (1)
Artificial Intelligence and Machine Learning in Clinical Medicine, 2023. (2023) (1)
Chemical Mediators of Immediate Hypersensitivity Reactions (2011) (1)
Maturation of the human bronchial epithelial cell (HBEC) layer causes a jamming transition, but compression of the layer, as in bronchospasm, causes unjamming (2015) (1)
Studies on the peptide core of human bronchial mucus glycoprotein. (1989) (1)
Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update (2023) (1)
Role of capsaicin‐sensitive neurons in histamine‐induced luminal liquid in small airways (1991) (1)
The pharmacogenetics of asthma and allergic disease (2002) (1)
Arachnoids and asthma: the role of receptors of leukotrienes (1991) (1)
Leukotriene receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
Endogenous pulmonary nitric oxide in the regulation of airway microvascular leak. (1998) (1)
Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. (2010) (0)
The Unborn Child: Scientific Discovery, Medical and Ethical Dilemmas Round Table Discussion (2005) (0)
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-1992. A 40-year-old woman with intermittent hemoptysis and mucosal ulceration found on bronchoscopic examination. (1992) (0)
An Opportunity for Greater Discovery (2013) (0)
1991 referees (2004) (0)
[Clinical trial registration: looking back and moving ahead]. (2007) (0)
Compressive Mechanical Stress Induces YKL-40 In Air-liquid Interface Cultured Airway Epithelial Cells (2010) (0)
Tropical Diseases (2003) (0)
Where is the surgeon general? (2014) (0)
Unmet Needs: Cancer Example (2013) (0)
Concurrent Engineering in the Clinic (2013) (0)
Erratum: (The Journal of Clinical Investigation (March 1997) 99:5) (1998) (0)
Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors. (2016) (0)
Global Initiative for Asthma (GINA): 30 years of promoting evidence-based asthma care. (2023) (0)
1990 referees (2007) (0)
response to reviewer #2 (2019) (0)
airway microvascular leak Endogenous pulmonary nitric oxide in the regulation of (2016) (0)
The Role of NO in the Lung (1997) (0)
Data sharing statements for clinical trials: a requirement of the International Committee of Medical Journal Editors. (2017) (0)
Original Communication Lack of association of NAT2 (N-acetyl transferase 2) gene polymorphism with atopic asthma in Turkish subjects (2004) (0)
Audio Interview: Vaccination in Nursing Homes and New Pulmonary/Critical Care Research. (2021) (0)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. (2005) (0)
decreases airway resistance and responsiveness Expression of nitric oxide synthase-2 in the lungs (2015) (0)
Statement for deling af kliniske data: Et krav fra The International Committee of Medical Journal Editors (2017) (0)
Life Lessons from Paul in the Face of Death. (2018) (0)
Leukotkiene E 4-induced airway hyperresponsivenlss of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide ledkotriene receptors (1999) (0)
From Peas To Genome: Engineering-Enabled Biological Research (2013) (0)
From Molecular Science to the Treatment of Allergy (1999) (0)
Erratum (2012) (0)
Chapter 33 – Pathophysiology of Asthma (2009) (0)
Discovery of Chromosomes and the Submicrometer Microscope (2013) (0)
Effects of beta adrenergic blockade on histamine and prostaglandin-F2 alpha responsiveness in the dog. (1981) (0)
RisksofLong-ActingBeta-AgonistsinAchievingAsthmaControl (2009) (0)
Sponsorship, authorship, and accountability. (2001) (0)
1982 References (2007) (0)
ACA standoff. (2013) (0)
Concurrent Engineering and Science (2013) (0)
Sponsorship, authorship, and accountability. (2001) (0)
clinical implications 01basic research Inhalation Challenge with Sultidopeptide Leukotrienes in Human Subjects (2017) (0)
Bronchial Epithelial Cells As A Source Of Angiogenic Mediators In The Airway Remodeling Of Asthma (2012) (0)
Editorial independence at the BMJ: NEJM editor says facts in letter are wrong and accusations reckless… (2004) (0)
1986 Referees (2007) (0)
Role of leukotriene antagonists inthe treatment and prevention ofacute asthma exacerbations (2007) (0)
CORRECTION (2001) (0)
DNA: Gels, Paper, and Columns (2013) (0)
Formylpeptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
Virtual Deliberate Practice: Assessing Clinical Reasoning Using an Illness Script-based Simulator (2023) (0)
A Look Forward - The Frontiers in Medicine Series. (2018) (0)
Genetic polymorphisms of 5-LO (1999) (0)
Mechanical forces induce an asthma gene signature in healthy airway epithelial cells (2020) (0)
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. (2006) (0)
Protein and DNA Automated Sequencing (2013) (0)
Contributors (2012) (0)
Human lung expresses unique y-glutamyl transpeptidase transcripts (2005) (0)
Leukotriene receptors (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database (2020) (0)
The FDA politics and plan B [editorial] (2004) (0)
Taurine 5 (2003) (0)
Book ReviewPhysiology and Pharmacology of the Airways (1981) (0)
Pneumococcal Vaccination in Older Adults (2011) (0)
INTERNATIONAL ADDICTIONS INFOLINE (2001) (0)
Novel technique for investigation of mechanotransduction in airway epithelial cells (1999) (0)
Follow-up in Montelukast Treatment (2000) (0)
Bronchoconstrictor activities of NP gamma and NPK in anaesthetized guinea-pigs: effect on NEP inhibition. (1993) (0)
Leukotriene Inhibitors: An Overview (2001) (0)
Exhaled nitric oxide as a measure of response to therapy in patients with heart failure (1996) (0)
Responsibility of Medical Journals : Papers on Allergy, Asthma and Related Topics (2005) (0)
Giants inChestMedicine (2017) (0)
Clinical trial registration: looking back and moving ahead. (2007) (0)
Unmet Needs: Mapping and Understanding Cell Signaling (2013) (0)
Structure of DNA and Proteins: X-ray Diffraction (2013) (0)
Notice of Retraction (2023) (0)
CO2 elimination by high-frequency oscillation: effects of vagosympathetic stimulation. (1986) (0)
Potential mechanosensory mechanisms in airway epithelial cells exposed to a transcellular pressure difference (2001) (0)
The Engineers and Scientists of Concurrent Engineering (2013) (0)
Engineering and the Engineer (2013) (0)
Fifteen Years. (2015) (0)
Dietary influences on inflammatory mediators as an approach to antiinflammatory drugs (1986) (0)
1992 referees (2004) (0)
Peer Review Journals in the Digital Age Revistas con revisión externa (peer review) en la era digital (2015) (0)
LEUKOTRIENE RECEPTOR ANTAGONISM AND SYNTHESIS INHIBITION IN CHRONIC STABLEASTHMA (1998) (0)
Dear AMSRJ Readers (2014) (0)
Chapter 26 – Interfering with the 5-Lipoxygenase Pathway as a Novel Way to Treat Asthma (1998) (0)
Interaction between Lung Mechanics and Gas Exchange by Low Volume High Frequency Pulmonary Ventilation in Patients with Respiratory Failure. (1985) (0)
A GENETIC APPROACH TO AIRWAY HYPERRESPONSIVENESS (1997) (0)
Sponsorship, authorship and accountability. (2001) (0)
Sharing Clinical Trial Data. (2016) (0)
The Effects of a Fish-Oil-enriched Diet on Pulmonary Mechanics during Anaphylaxis1–3 (2015) (0)
Making An Impact on Clinical Practice and Research in China. (2016) (0)
Albuterol Treatment in Mild Asthma (1997) (0)
Mechanisms of gas transport during high frequency ventilation investigation with single breath nitrogen washout curves (1982) (0)
Peer review journals in the digital age (2010) (0)
Genes, Environment, and Loss of Lung Function in Premature Infants (2023) (0)
Airway epithelial compression: A stimulus for airway remodeling in asthma (2001) (0)
Epithelial-fibroblast interactions in response to mechanical stresses in the airways: an in vitro study (1999) (0)
NEJM Group — More Offerings, Mission Unchanged (2013) (0)
Observing DNA and Protein in Action: Radioisotope Labels (2013) (0)
Research Data - Case No. 92-7 (1992) (0)
Effects of preferential deposition of histamine in the human airway. (1978) (0)
Thank You (2007) (0)
Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors. (2016) (0)
HyperresponsivenessPulmonary Eosinophilia and Airway for the Development of Antigen-Induced CC Chemokine Receptor-2 Is Not Essential (2000) (0)
1989 referees (2007) (0)
Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. (1999) (0)
Uniform format for disclosure of competing interests in ICMJE journals. (2010) (0)
2 From shotguns to rifles : Pharmacogenetics in drug discovery and treatment (2005) (0)
Pulmonary rehabilitation. Asthma and COPD (2002) (0)
Moving Ahead with a New NEJM.org. (2018) (0)
9. Financial associations of authors (2012) (0)
Acknowledgements (1997) (0)
Firearm-Related Injury and Death: A U.S. Health Care Crisis in Need of Health Care Professionals (2017) (0)
Mechano-Transduction in Murine Tracheal Epithelial Cells. (2009) (0)
Institutions and Teams for Concurrent Biology and Engineering (2013) (0)
response to reviewer #1 (2019) (0)
Book Review (1999) (0)
Modulation of aquaporin 4 and the amiloride-inhibitable sodium channel in perinatal rat lung epithelial cells. (1998) (0)
Changes in aerosol-derived airspace diameter induced by bronchoconstrictors and alterations in lung volume (1990) (0)
Concurrent versus Nonconcurrent Engineering (2013) (0)
Experimental Induction of Chronic Bronchitis in Dogs (2015) (0)
Transcription and Electron Microscopy (2013) (0)
Genetics of the nitric oxide synthetic pathway in asthma (2002) (0)
Leukotrienes and Airway Responses: Reply (1988) (0)
The naïve airway hyperresponsiveness of the A/J mouse is Kit-mediated (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 31 (12787-12792) DOI (2011) (0)
Concurrent Engineering and Biology (2013) (0)
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. (2004) (0)
Antigen-antibody mediated desensitization of human lung fragments in vitro. (1973) (0)
Biographical Sketch of Dr. Alec H. Sehon (1991) (0)

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