Jeffrey Flier

Q: What Schools Are Affiliated With Jeffrey Flier

Jeffrey Flier is affiliated with the following schools: City College of New York, Icahn School of Medicine at Mount Sinai, Pennsylvania State University, Massachusetts Institute of Technology, Rush University, Harvard University

Jeffrey Flier's AcademicInfluence.com Rankings

Jeffrey Flier

Philosophy

#3047

World Rank

#5014

Historical Rank

#1007

USA Rank

Logic

#951

World Rank

#1548

Historical Rank

#321

USA Rank

philosophy Degrees

Download Badge

Philosophy

Jeffrey Flier's Degrees

Doctorate Medicine Harvard University

Why Is Jeffrey Flier Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Jeffrey Flier is an American physician, endocrinologist; widely cited scientist; the Higginson Professor of Medicine and Physiology at Harvard Medical School; and a Distinguished Service Professor at the same institution. He was the 21st Dean of the Faculty of Medicine at Harvard University from 2007 to 2016.

(See a Problem?)

Jeffrey Flier's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Adipose tissue as an endocrine organ. (2004) (3871)
TLR4 links innate immunity and fatty acid-induced insulin resistance. (2006) (3337)
Role of leptin in the neuroendocrine response to fasting (1996) (3087)
Obesity and the Regulation of Energy Balance (2001) (2320)
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome (2001) (1815)
Obesity and insulin resistance. (2000) (1688)
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action (1995) (1636)
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. (2007) (1363)
The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene* (1997) (1292)
Adipogenesis and Obesity: Rounding Out the Big Picture (1996) (1279)
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. (2012) (1278)
Obesity Wars Molecular Progress Confronts an Expanding Epidemic (2004) (1217)
Mice lacking melanin-concentrating hormone are hypophagic and lean (1998) (1140)
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue (1993) (1071)
Distributions of leptin receptor mRNA isoforms in the rat brain (1998) (1067)
Identification of SOCS-3 as a potential mediator of central leptin resistance. (1998) (1029)
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor* (1997) (940)
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area (1999) (896)
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. (2000) (866)
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. (1997) (839)
Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia (1997) (832)
Insulin resistance--mechanisms, syndromes, and implications. (1991) (817)
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. (1987) (787)
Leptin Regulation of Neuroendocrine Systems (2000) (755)
UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. (1997) (748)
Leptin accelerates the onset of puberty in normal female mice. (1997) (746)
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. (2004) (710)
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State (2010) (673)
Human leptin levels are pulsatile and inversely related to pituitary–ardenal function (1997) (670)
Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance (2005) (669)
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. (1996) (665)
The Role of SOCS-3 in Leptin Signaling and Leptin Resistance* (1999) (656)
Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. (1998) (637)
Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. (2001) (618)
Leptin Regulation of the Mesoaccumbens Dopamine Pathway (2006) (605)
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. (1995) (600)
Clinical review 94: What's in a name? In search of leptin's physiologic role. (1998) (585)
SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985 * (2000) (534)
The Gut and Energy Balance: Visceral Allies in the Obesity Wars (2005) (531)
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. (2004) (527)
Unraveling the central nervous system pathways underlying responses to leptin (1998) (527)
Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. (1997) (511)
A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. (1997) (500)
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 (2004) (489)
Targeted Disruption of the β3-Adrenergic Receptor Gene * (1995) (451)
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. (2003) (449)
Obesity and the Hypothalamus: Novel Peptides for New Pathways (1998) (445)
Leptin activates neurons in ventrobasal hypothalamus and brainstem. (1997) (432)
Characterization of the insulin resistance of aging. (1983) (412)
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. (1998) (395)
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. (1987) (371)
Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM (1990) (370)
Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. (2006) (369)
Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors* (2001) (365)
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. (1992) (362)
Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation (2001) (352)
Activation of β3 Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in Mice (1996) (349)
Attenuation of leptin and insulin signaling by SOCS proteins (2006) (346)
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. (2009) (335)
Regulation of neuronal and glial proteins by leptin: implications for brain development. (1999) (326)
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. (2001) (326)
Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. (1997) (313)
Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus. (1997) (311)
The adipocyte: Storage depot or node on the energy information superhighway? (1995) (310)
Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. (1998) (307)
Severely impaired adipsin expression in genetic and acquired obesity. (1987) (302)
Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. (1989) (301)
Reduced activity of the red-cell sodium-potassium pump in human obesity. (1980) (295)
Adipsin Is an Adipokine that Improves β Cell Function in Diabetes (2014) (274)
Expression of leptin receptor isoforms in rat brain microvessels. (1998) (263)
Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. (2012) (263)
Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation With Obesity (1996) (261)
The adipocyte as an active participant in energy balance and metabolism. (2007) (259)
Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity. (2002) (257)
Nasal absorption of insulin: enhancement by hydrophobic bile salts. (1985) (256)
α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors (2013) (255)
Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. (1999) (253)
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. (2005) (248)
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. (1992) (247)
Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue (2007) (244)
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. (2000) (243)
Evidence for constitutive neural cell proliferation in the adult murine hypothalamus (2007) (242)
Leptin expression and action: new experimental paradigms. (1997) (242)
Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. (2002) (239)
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype (2003) (238)
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling* (2004) (235)
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. (2006) (233)
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. (2011) (230)
Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. (1997) (227)
Leptin concentrations in relation to body mass index and the tumor necrosis factor-α system in humans (1997) (226)
Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. (1997) (224)
Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. (2000) (222)
Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. (1996) (222)
Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. (2000) (220)
Leptin Regulates Prothyrotropin-releasing Hormone Biosynthesis (2000) (219)
Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain. (1997) (217)
Leptin concentrations in the polycystic ovary syndrome. (1997) (213)
Complex Role of the Vitamin D Receptor and Its Ligand in Adipogenesis in 3T3-L1 Cells* (2006) (213)
Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. (2002) (210)
Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. (2001) (209)
Making evolutionary biology a basic science for medicine (2010) (207)
Expression of Leptin Receptor Isoforms in Rat Brain Microvessels. (1998) (205)
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. (2014) (204)
Sex differences in circulating human leptin pulse amplitude: clinical implications. (1998) (199)
The Human Uncoupling Protein-3 Gene (1997) (198)
Insulin Administered Intranasally as an Insulin-Bile Salt Aerosol: Effectiveness and Reproducibility in Normal and Diabetic Subjects (1983) (198)
Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (*) (1996) (190)
Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects (1996) (189)
Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans. (1997) (184)
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice. (2015) (182)
Regulated Production of a Peroxisome Proliferator-activated Receptor-γ Ligand during an Early Phase of Adipocyte Differentiation in 3T3-L1 Adipocytes* (2004) (178)
PPARγ regulates adipose triglyceride lipase in adipocytes in vitro and in vivo (2007) (177)
Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. (1998) (169)
Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. (1987) (168)
Xanthine Oxidoreductase Is a Regulator of Adipogenesis and PPARγ Activity (2007) (164)
Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. (1999) (164)
Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. (1989) (162)
Acanthosis nigricans in Obese Women with Hyperandrogenism: Characterization of an Insulin-Resistant State Distinct from the Type A and B Syndromes (1985) (162)
Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. (1991) (160)
Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (1999) (157)
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. (2002) (155)
Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice (2008) (154)
Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). (1988) (150)
Ligand-binding properties of the two isoforms of the human insulin receptor. (1993) (142)
Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. (2003) (142)
Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns. (1997) (139)
Arcuate Nucleus Ablation Prevents Fasting-Induced Suppression of ProTRH mRNA in the Hypothalamic Paraventricular Nucleus (1998) (138)
Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway (*) (1996) (134)
The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions. (1999) (129)
Ligand-independent Activation Domain in the N Terminus of Peroxisome Proliferator-activated Receptor γ (PPARγ) (1997) (129)
Genetic Variability in the TNF-α Promoter Is Not Associated with Type II Diabetes Mellitus (NIDDM) (1995) (127)
Regulation of Glucose-Transporter Gene Expression In Vitro and In Vivo (1990) (126)
High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. (1991) (122)
Diabetes: The missing link with obesity? (2001) (118)
Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men. (1998) (118)
A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance. (1990) (118)
Detection of Mutations in Insulin-Receptor Gene in NIDDM Patients by Analysis of Single-Stranded Conformation Polymorphisms (1991) (116)
Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. (1992) (116)
The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells (2001) (115)
Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia1. (1999) (114)
Prevalence of Mutations in the Insulin Receptor Gene in Subjects With Features of the Type A Syndrome of Insulin Resistance (1994) (114)
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. (2006) (112)
Endocrine function of neuropeptide Y knockout mice (1997) (110)
Leptin as a Therapeutic Agent—Trials and Tribulations (2000) (110)
Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in a PPARα-dependent Manner* (2010) (110)
Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep. (1987) (109)
Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling* (2009) (108)
Platelet-derived growth factor regulates glucose transporter expression. (1988) (107)
Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes (1991) (107)
Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. (1998) (105)
Brown adipose tissue, beta 3-adrenergic receptors, and obesity. (1997) (102)
Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes? (2017) (101)
The Fat-Brain Axis Enters a New Dimension (2004) (100)
Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat (1995) (97)
Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome. (2003) (96)
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. (2008) (96)
Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury (2017) (96)
Clinical, Biochemical, and Ovarian Morphologic Features in Women With Acanthosis Nigricans and Masculinization (1985) (93)
Receptors for peptide hormones. New insights into the pathophysiology of disease states in man. (1977) (93)
Insulin resistance: the clinical spectrum. (1995) (93)
Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas (2016) (90)
Impaired in Vivo Insulin Clearance in Patients With Severe Target-Cell Resistance to Insulin (1982) (90)
Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor. (1999) (90)
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. (2007) (88)
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. (1993) (87)
Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. (1998) (86)
Functional Properties of Leptin Receptor Isoforms Containing the Gln→Pro Extracellular Domain Mutation of the Fatty Rat. (1998) (83)
Familial insulin resistance with acanthosis nigricans, acral hypertrophy, and muscle cramps. (1980) (82)
Differential Regulation of Two Glucose Transporters in Rat Liver by Fasting and Refeeding and by Diabetes and Insulin Treatment (1990) (81)
Lilly Lecture: Syndromes of Insulin Resistance: From Patient to Gene and Back Again (1992) (81)
Lowered leptin slims immune response (1998) (80)
Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations (1998) (79)
Increased CCL27–CCR10 expression in allergic contact dermatitis: implications for local skin memory (2004) (77)
Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells. (2000) (76)
Insulin receptors and insulin resistance. (1983) (73)
Normal Insulin-Receptor cDNA Sequence in Pima Indians With NIDDM (1989) (73)
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3 (1994) (73)
Molecular Scanning of Insulin-Responsive Glucose Transporter (GLUT4) Gene in NIDDM Subjects (1991) (73)
Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. (2015) (71)
Metabolic importance of acanthosis nigricans. (1985) (71)
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts (2007) (71)
Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. (2004) (71)
PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. (2007) (70)
Editorial: leptin as a therapeutic agent--trials and tribulations. (2000) (67)
Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. (2009) (67)
Endogenous digitalis-like activity in the plasma of the toad Bufo marinus (1979) (66)
Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number. (1989) (66)
Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. (1999) (64)
Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis. (1984) (64)
Characterization of Binding and Phosphorylation Defects of Erythrocyte Insulin Receptors in the Type A Syndrome of Insulin Resistance (1986) (63)
Chemokine IP-10 expression in cultured human keratinocytes (1998) (62)
Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. (1999) (62)
Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant. (1991) (60)
Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. (1999) (59)
Obesity research springs a proton leak (1997) (56)
Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance (2010) (56)
Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet (2018) (56)
AgRP in energy balance: Will the real AgRP please stand up? (2006) (55)
Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia. (1996) (55)
Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. (1998) (55)
Developing Core Competencies for the Prevention and Management of Prescription Drug Misuse: A Medical Education Collaboration in Massachusetts (2016) (54)
The Neuroprotective Antioxidant α-lipoic Acid Induces Detoxication Enzymes in Cultured Astroglial Cells (2002) (51)
Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor. (1990) (51)
Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). (1995) (50)
Status of the red cell Na,K-pump in hyper- and hypothyroidism. (1983) (49)
Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cells. (1989) (48)
Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. (2003) (47)
Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. (1998) (46)
Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation. (1992) (45)
Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice (2011) (45)
Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism (2011) (44)
An Introduction to Receptors and Receptor Disorders (1979) (44)
Pushing the envelope on lipodystrophy (2000) (42)
Biological activity of nasally administered insulin in normal subjects. (1990) (42)
Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport (1978) (41)
A Good Night's Sleep: Future Antidote to the Obesity Epidemic? (2004) (41)
Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin (2018) (40)
Overexpression of Ha-ras Selectively in Adipose Tissue of Transgenic Mice (1996) (39)
Irreproducibility of published bioscience research: Diagnosis, pathogenesis and therapy (2016) (39)
Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice. (1989) (39)
ADD-1 provides major new insight into the mechanism of insulin action. (1999) (38)
The stomach speaks--ghrelin and weight regulation. (2002) (38)
Vanadate regulates glucose transporter (Glut-1) expression in NIH3T3 mouse fibroblasts. (1990) (36)
The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells. (2002) (34)
Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. (2002) (34)
Regulating Energy Balance: The Substrate Strikes Back (2006) (33)
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. (1990) (31)
Effect of Sucrose Overfeeding on Na,K-ATPase-Mediated 86Rb Uptake in Normal and ob/ob Mice (1981) (31)
Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. (2014) (31)
Obesity after genetic ablation of brown adipose tissue. (1998) (30)
Chewing the Fat--ACC and Energy Balance (2001) (30)
Hormone Resistance in Diabetes and Obesity: Insulin, Leptin, and FGF21 (2012) (29)
Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice (2017) (28)
U-500 insulin in the treatment of antibody-mediated insulin resistance. (1981) (28)
Fibroblast growth factor 21 has no direct role in regulating fertility in female mice (2016) (28)
Lasker Lauds Leptin (2010) (27)
Gut Check: Testing a Role for the Intestinal Microbiome in Human Obesity (2009) (26)
Functionally abnormal Na+-K+ pump in erythrocytes of a morbidly obese patient. (1982) (26)
Primer Energy homeostasis and body weight (2000) (25)
Physiology: Is brain sympathetic to bone? (2002) (25)
Faculty promotion must assess reproducibility (2017) (24)
Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes. (1990) (22)
Insulin-Resistant Diabetes with Insulin Receptor Autoantibodies in a Male Patient Without Acanghosis Nigricans (1979) (22)
The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes (2006) (21)
Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S 6 Kinase 2 (2003) (21)
What fuels fat. (2007) (21)
Adipsin: regulation and dysregulation in obesity and other metabolic states. (1989) (21)
Altered erythrocyte Na+ + K+ pump in adolescent obesity. (1982) (20)
Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (1994) (20)
Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA. (1989) (20)
Erythrocyte sodium-potassium-ATPase and obesity. (1982) (19)
Energetic pursuit of leptin function (1997) (19)
Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis. (1988) (19)
Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis (2019) (18)
The stimulation of pp42mapkinase by insulin does not correlate with its metabolic actions in cells overexpressing mutant insulin receptors. (1993) (17)
Effect of diet upon the erythrocyte Na,K pump. (1983) (17)
Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a welsh type 2 (non-insulin-dependent) diabetic population (1992) (17)
IP-10 mRNA expression in cultured keratinocytes is suppressed by inhibition of protein kinase-C and tyrosine kinase and elevation of cAMP. (1999) (17)
Evidence for coordinate genetic control of Na,K pump density in erythrocytes and lymphocytes. (1985) (17)
Muscle-Specific Expression of Human Insulin Receptor in Transgenic Mice (1993) (17)
Neuroscience. Regulating energy balance: the substrate strikes back. (2006) (15)
The potential significance of beta 3 adrenergic receptors. (1995) (15)
Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach. (2017) (14)
Insulin: A pacesetter for the shape of modern biomedical science and the Nobel Prize (2021) (13)
Cell biology. Chewing the fat--ACC and energy balance. (2001) (12)
Evidence that metformin increases insulin-stimulated glucose transport by potentiating insulin-induced translocation of glucose transporters from an intracellular pool to the cell surface in rat adipocytes. (1992) (12)
Conference coverage: Selected presentations from the 20th Annual Practical Approaches to the Treatment of Obesity; June 22-24, 2006 (2006) (12)
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus. (1996) (12)
Academia and industry: allocating credit for discovery and development of new therapies. (2019) (11)
Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy. (1989) (10)
Clinical Endocrinology 6 Metabolism Editor-in-chief: Delbert A. Fisher (10)
Development of morbid obesity in transgenic mice following the genetic ablation of brown adipose tissue (1993) (10)
Lasker lauds leptin. (2010) (8)
Categorizing biomedical research: the basics of translation (2017) (8)
Alterations in sympathetic nervous system activity do not regulate adipsin gene expression in mice. (1991) (7)
Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (2020) (6)
Erratum: Regulated production of a peroxisome proliferator-activated receptor-γ ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes (Journal of Biological Chemistry (2004) 279 (36093-36102)) (2004) (6)
Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression. (1989) (6)
to Ketosis Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation (2009) (6)
Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM. (1975) (6)
Credit and Priority in Scientific Discovery: A Scientist’s Perspective (2019) (5)
Creating a Nobel culture. (2013) (4)
Health care reform: without a correct diagnosis, there is no cure. (2009) (3)
Cell Metabolism: Why, and why now? (2005) (3)
Biologic Activities of Naturally Occurring Human Insulin Receptor Mutations THAT METABOLIC EFFECTS OF INSULIN CAN BE MEDIATED BY A KINASE-DEFICIENT (1991) (3)
C. Ronald Kahn: The Louisville Slugger of metabolic science. (2019) (3)
Leptin I (1999) (3)
Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions. (2017) (3)
Reduced intra-adipose glucocorticoid regeneration: A novel adaptive response to, and therapy for, the metabolic syndrome (2003) (3)
All you can't eat (2007) (2)
Strategic Planning at Harvard Medical School (2008) (2)
Augmentation of renal vasoconstrictor responses to norepinephrine and angiotensinii by leptin. (1999) (2)
Big deal about a little insulin (1999) (2)
O-2: Leptin secretion by the adipocyte: Regulation with genetic and dietary obesity and search for an intracellular storage pool (2009) (2)
Loss of insulin binding and insulin receptor mRNA in a transformed human fetal fibroblast cell line. (1990) (2)
Cytogenetic studies of a male with sporadic intestinal lymphangiectasia: 45,X/46,XY mosaicism with pseudo- and hyperdiploid subpopulations in cultured tissues. (1979) (2)
Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat. (1998) (2)
The US Health Provider Workforce: Determinants and Potential Paths to Enhancement (2020) (1)
Differential expression of IFN-γ induced CXC chemokines IP-10 and MIG in inflammatory skin diseases (1998) (1)
Characteristics of in vitro steroidogenesis in a woman with hyperandrogenism, a granulosa cell tumor and polycystic ovary disease. A case report. (1988) (1)
Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in mice (2020) (1)
Book Review Insulin Resistance: The metabolic syndrome X (Contemporary Endocrinology.) Edited by Gerald M. Reaven and Ami Laws. 374 pp. Totowa, N.J., Humana Press, 1999. $145. 0-89603-588-3 (1999) (1)
The Problem of Irreproducible Bioscience Research (2022) (1)
Misconduct in Bioscience Research: a 40-year perspective (2021) (1)
Adipogenesis and Obesity: Review Rounding Out the Big Picture (1996) (1)
Is France Once Again Looking for a Scapegoat? (2021) (1)
Identification of novel hypothalamic genes that are regulated by leptin and play a role in development of leptin-resistance and obesity (1999) (1)
FS02.2 CD4+ CCR10+ effector T cells reside at former allergic contact dermatitis sites (2004) (1)
Functionally Abnormal Na/K Pump in Erythrocytes from a Morbidly Obese Subject (1983) (0)
Douris - Supplemental - en-14-2001 (2015) (0)
Cloning andCharacterization ofp97ZAPK, a NovelHuman HomologofRatERK-3 (1994) (0)
Nasalabsorption ofinsulin: Enhancement byhydrophobic bile salts (drugabsorption/hydrophobicity/mixed micelies/reverse micelles/steroid detergents) (1985) (0)
On diabetes : insulin resistance output (2000) (0)
B-5. 抗インスリン受容体抗体の見いだされたインスリン抵抗性糖尿病を合併したSjogren症候群 (1976) (0)
ADIPSIN IS AN ADIPOCYTOKINE DYSREGULATED IN OBESITY/METABOLIC SYNDROME THAT SUSTAINS CARDIOVASCULAR HEALTH (2014) (0)
ARALAST or ANTI-TNF-a TREATMENT PREVENTS AUTOIMMUNE DESTRUCTION OF ISLET GRAFTS IN NONOBESE DIABETIC (NOD) MICE (131.23) (2007) (0)
Mice lackingmelanin-concentratinghormone arehypophagicand lean (1998) (0)
Former Harvard dean ' s tweet against required faculty diversity statements sets off debate (2020) (0)
脂肪組織における11βHSD1 : メタボリック・シンドローム(代謝異常症候群)における役割 (2003) (0)
Altered erythrocyte Na/sup +/ + K/sup +/ pump in adolescent obesity (1982) (0)
EDITORIAL Leptin, Nutrition, and Reproduction: Timing Is Everything (2000) (0)
Immunosuppression by alpha blockade. (1971) (0)
Regulation of Hypothalamic Neurons (1998) (0)
A composition for administration of systemically acting compounds via mucous membranes (1984) (0)
The US Health Provider Workforce (2020) (0)
Basic research in obesity: incredible insights but limited effects on clinical outcomes (2019) (0)
In Reply to Manion and Khan. (2017) (0)
Moderating "the great debate": The carbohydrate-insulin vs. the energy balance models of obesity. (2023) (0)
Characterization of Expression of Hypothalamic Appetite-Regulating Peptides in Obese Hyperleptinemic Brown Adipose Tissue-Deficient (Uncoupling Protein-Promoter-Driven Diphtheria Toxin A) Mice* *This work was supported by a grant from Eli Lilly & Co. (to E.M.F.), NIH Grant DK-R37-28082 (to J.S.F.), (1998) (0)
2015 Joseph B. Martin Dean's Leadership Award for the Advancement of Women Staff (2014) (0)
Medical preparation for absorption through the body surface (1984) (0)
Identification of IP-9, a novel CXC-chemokine expressed by keratinocytes (1998) (0)
The diagnosis of diabetes: who is a diabetic and why? (1985) (0)
Problems of insulin resistance. (1988) (0)
Address by Chairman and Chief Executive Officer, Aetna Life & Casualty Company. (1982) (0)
Regulation of expression of the chemokine CCL27 (CTACK) during allergic contact dermatitis (2002) (0)
Questions and answers on diabetes. A panel discussion. (1985) (0)
生理学なぜ太ってしまうのか (特集肥満と食糧危機--世界を蝕むパラドックス) (2007) (0)
Beth Israel Deaconess Medical Center Receives $500,000 Bristol-Myers Squibb Unrestricted Metabolic Research Grant (2004) (0)
新しい内臓脂肪型肥満・代謝症候群モデルマウスの開発 (特集肥満症の分子メカニズム--アディポサイエンス最前線) (2002) (0)
Receptors for Peptide Hormones (2020) (0)
THE PHYSIOLOGICAL ROLE OF LEPTIN IN ENERGY HOMEOSTASIS (2019) (0)
706 NASH with pericentral fibrosis and neutrophil inflammation in mice overexpressing 11α-Hydroxysteroid-Dehydrogenase (HSD-1) in adipose tissue (2006) (0)
, Obesity Wars The Gut and Energy Balance : Visceral Allies in the (2010) (0)
Form of administration of medicines. (1984) (0)
Kokoeva Energy Balance Neurogenesis in the Hypothalamus of Adult Mice : Potential Role in (2012) (0)
The Diversity of Institutions Conducting Biomedical Research (2023) (0)
Overfeeding stimulates heptatic na,k-atpase activity in normal but not ob/ob mice. Abstr. (1981) (0)
The Diversity of Institutions Conducting Biomedical Research (2023) (0)
, MD Dean of the Faculty of Medicine The Emerging Priorities (2008) (0)
Defect in membrane na+ + k+-atpase in obese mouse and man. Abstr. (1980) (0)
Abdominal Visceral Fat (AVF) is Related to Energy Expenditure, Leptin, and Fat Mass in Children and Adolescents † 473 (1998) (0)
THE POWERFUL T-CELL TOLERIZING CONSEQUENCES OF BLOCKING EXPRESSION OF PRO-, NOT ANTI-INFLAMMATORY MECHANISM: 297 (2008) (0)

This paper list is powered by the following services:

Other Resources About Jeffrey Flier

en.wikipedia.org

What Schools Are Affiliated With Jeffrey Flier?

Jeffrey Flier is affiliated with the following schools:

Jeffrey Flier's Academic­Influence.com Rankings