Jeffrey Wine
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Biologist
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Biology
Jeffrey Wine's Degrees
- Bachelors Biology University of California, Berkeley
- Masters Biological Sciences Stanford University
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(Suggest an Edit or Addition)According to Wikipedia, Jeffrey J. Wine is an American biologist and professor. He is currently at Stanford University and an Elected Fellow of the American Association for the Advancement of Science. His research has focused on the genetic disease cystic fibrosis.
Jeffrey Wine's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809 (2011) (963)
- Glycerol Reverses the Misfolding Phenotype of the Most Common Cystic Fibrosis Mutation (*) (1996) (554)
- Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. (1994) (358)
- Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. (2010) (342)
- The organization of escape behaviour in the crayfish. (1972) (315)
- A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. (2002) (252)
- Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus (1998) (216)
- Submucosal glands and airway defense. (2004) (216)
- Safety and Biological Efficacy of an Adeno‐Associated Virus Vector–Cystic Fibrosis Transmembrane Regulator (AAV‐CFTR) in the Cystic Fibrosis Maxillary Sinus (1999) (212)
- The Structural Basis of an Innate Behavioural Pattern (1984) (206)
- Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na+] and pH but elevated viscosity (2001) (195)
- Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP (1996) (194)
- The genesis of cystic fibrosis lung disease. (1999) (192)
- Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells. (1991) (148)
- Airway Gland Structure and Function. (2015) (145)
- CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance. (1994) (144)
- Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines. (1996) (139)
- Presynaptic Inhibition: Primary Afferent Depolarization in Crayfish Neurons (1974) (127)
- Connectivity Patterns of Crayfish Giant Interneurons: Visualization of Synaptic Regions with Cobalt Dye (1973) (119)
- Absent Secretion to Vasoactive Intestinal Peptide in Cystic Fibrosis Airway Glands* (2002) (118)
- Physiological consequences of a peptide cotransmitter in a crayfish nerve-muscle preparation (1987) (108)
- Parasympathetic control of airway submucosal glands: Central reflexes and the airway intrinsic nervous system (2007) (108)
- Hyposecretion, Not Hyperabsorption, Is the Basic Defect of Cystic Fibrosis Airway Glands*♦ (2006) (106)
- CFTR channels in immortalized human airway cells. (1992) (105)
- Segmental homology and variation in flexor motoneurons of the crayfish abdomen (1978) (102)
- Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis. (2007) (98)
- Extrinsic modulation of crayfish escape behaviour. (1975) (97)
- Calcium-stimulated Cl-secretion in Calu-3 human airway cells requires CFTR. (1997) (90)
- A Phase I/II Study of tgAAV-CF for the Treatment of Chronic Sinusitis in Patients with Cystic Fibrosis. Stanford University, Stanford, California (1998) (87)
- Neuropeptide proctolin in postural motoneurons of the crayfish (1984) (82)
- Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs. (2010) (81)
- Optical method for quantifying rates of mucus secretion from single submucosal glands. (2001) (81)
- Mucus Secretion from Single Submucosal Glands of Pig (2002) (80)
- The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin (2017) (77)
- The Production of Crayfish Tailflip Escape Responses (1984) (73)
- High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia. (2019) (73)
- Hyposecretion of β-Adrenergically Induced Sweating in Cystic Fibrosis Heterozygotes (1987) (69)
- Evidence that Calu-3 human airway cells secrete bicarbonate. (1998) (69)
- Mucus secretion by single tracheal submucosal glands from normal and cystic fibrosis transmembrane conductance regulator knockout mice (2007) (69)
- Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains (2010) (64)
- Cystic fibrosis gene expression is not correlated with rectifying Cl- channels. (1991) (61)
- Regulation of Antiprotease and Antimicrobial Protein Secretion by Airway Submucosal Gland Serous Cells* (2004) (59)
- Segmental giant: evidence for a driver neuron interposed between command and motor neurons in the crayfish escape system. (1982) (57)
- Acid and base secretion in the Calu-3 model of human serous cells. (2004) (56)
- Interneurons between giant axons and motoneurons in crayfish escape circuitry. (1981) (56)
- Most basal I(SC) in Calu-3 human airway cells is bicarbonate-dependent Cl- secretion. (1997) (55)
- Control of Crayfish Escape Behavior (1977) (53)
- A Little CFTR Goes a Long Way: CFTR-Dependent Sweat Secretion from G551D and R117H-5T Cystic Fibrosis Subjects Taking Ivacaftor (2014) (51)
- Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process. (2009) (50)
- Ion channels in normal human and cystic fibrosis sweat gland cells. (1989) (49)
- Invertebrate central neurons: orthograde degeneration and retrograde changes after axonotomy. (1973) (49)
- Selection for MDR1/P-glycoprotein enhances swelling-activated K+ and Cl- currents in NIH/3T3 cells. (1994) (48)
- Habituation and inhibition of the crayfish lateral giant fibre escape response. (1975) (47)
- A phase I/II study of tgAAV-CF for the treatment of chronic sinusitis in patients with cystic fibrosis. (1998) (47)
- Temporal organization of crayfish escape behavior: delayed recruitment of peripheral inhibition. (1977) (45)
- Neuronal organization of crayfish escape behavior: inhibition of giant motoneuron via a disynaptic pathway from other motoneurons. (1977) (44)
- Coordination of lateral giant and non-giant systems in crayfish escape behavior (1983) (43)
- Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers (2018) (42)
- Identified interneurons produce both primary afferent depolarization and presynaptic inhibition. (1984) (41)
- Identified nonspiking local interneurons mediate nonrecurrent, lateral inhibition of crayfish mechanosensory interneurons (1983) (40)
- Local interneurons in the terminal abdominal ganglion of the crayfish (1982) (40)
- Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR-/- and CFTRΔF508/ΔF508 Pigs (2011) (40)
- The structure of tonic flexor motoneurons in crayfish abdominal ganglia (1974) (39)
- The basic defect in cystic fibrosis. (1991) (39)
- Acinar origin of CFTR-dependent airway submucosal gland fluid secretion. (2007) (39)
- Proteomic Analysis of Pure Human Airway Gland Mucus Reveals a Large Component of Protective Proteins (2015) (39)
- Two novel mutations in a cystic fibrosis patient of Chinese origin (1999) (39)
- HCO3- transport in relation to mucus secretion from submucosal glands. (2001) (39)
- Transient, axotomy‐induced changes in the membrane properties of crayfish central neurones. (1981) (36)
- Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands (2008) (35)
- Neural mechanisms for serial order in a stereotyped behaviour sequence (1982) (34)
- Mechanosensory integration in the crayfish abdominal nervous system: Structural and physiological differences between interneurons with single and multiple spike initiating sites (1982) (34)
- In Vivo Readout of CFTR Function: Ratiometric Measurement of CFTR-Dependent Secretion by Individual, Identifiable Human Sweat Glands (2013) (34)
- Progress in understanding mucus abnormalities in cystic fibrosis airways. (2017) (32)
- Cystic fibrosis: The ‘bicarbonate before chloride’ hypothesis (2001) (31)
- Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands. (2011) (30)
- Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. (2009) (29)
- Comprehensive mutation screening in a cystic fibrosis center. (2001) (29)
- THE TELSON FLEXOR NEUROMUSCULAR SYSTEM OF THE CRAYFISH I. HOMOLOGY WITH THE FAST FLEXOR SYSTEM (1987) (28)
- Crayfish escape behavior: Neurobehavioral analysis of phasic extension reveals dual systems for motor control (1981) (27)
- Crayfish escape behavior (2004) (26)
- Mucus secretion from individual submucosal glands of the ferret trachea. (2010) (25)
- Stilbenes stimulate T84 Cl- secretion by elevating Ca2+. (1993) (25)
- A "virtual gland" method for quantifying epithelial fluid secretion. (2004) (24)
- Cystic fibrosis advantage (1988) (24)
- An Inwardly Rectifying Potassium Channel in Apical Membrane of Calu-3 Cells* (2004) (23)
- The Development of Lung Disease in Cystic Fibrosis Pigs (2010) (23)
- Segmental differences in pathways between crayfish giant axons and fast flexor motoneurons. (1985) (22)
- Maxillary sinusitis as a surrogate model for CF gene therapy clinical trials in patients with antrostomies (1999) (22)
- Crayfish Escape Behaviour: Commands for Fast Movement Inhibit Postural Tone and Reflexes, and Prevent Habituation of Slow Reflexes (1979) (22)
- Evidence that CFTR Channels Can Regulate the Open Duration of other CFTR Channels: Cooperativity (2001) (21)
- Frequency coding of waterborne vibrations by abdominal mechanosensory interneurons in the crayfish,Procambarus clarkii (1986) (21)
- Method for rapid evaluation of topically applied agents to cystic fibrosis airways. (1991) (20)
- Peptide potentiation of calcium channel activity can be seasonally variable. (1991) (19)
- II. Command-derived Inhibition of Abdominal Extension (1977) (19)
- Crayfish neurons with electrogenic cell bodies: correlations with function and dendritic properties (1975) (18)
- Cystic Fibrosis: How do CFTR mutations cause cystic fibrosis? (1995) (18)
- Cell-volume regulation: P-glycoprotein – a cautionary tale (1996) (18)
- Cystic fibrosis, the CFTR, and rectifying Cl- channels. (1991) (18)
- Evaporimeter and Bubble-Imaging Measures of Sweat Gland Secretion Rates (2016) (17)
- CFTR and other Cl- channels in human airway cells. (1994) (17)
- Mucociliary clearance and submucosal gland secretion in the ex vivo ferret trachea. (2014) (17)
- Disruption of monolayer integrity enables activation of a cystic fibrosis “bypass” channel in human airway epithelia (1997) (16)
- Dissociation of depolarization-activated and swelling-activated Cl- channels. (1994) (16)
- Evidence that Calu-3 human airway cells secrete bicarbonate. (1998) (15)
- Measurement of fluid secretion from intact airway submucosal glands. (2011) (15)
- Patch-clamp study of cultured human sweat duct cells: amiloride-blockable Na+ channel (1989) (15)
- Crayfish escape behavior (2004) (15)
- Doxorubicin selection for MDR1/P-glycoprotein reduces swelling-activated K+ and Cl- currents in MES-SA cells. (1996) (15)
- CFTR Activation Raises Extracellular pH of NIH/3T3 Mouse Fibroblasts and C127 Epithelial Cells (2001) (14)
- Durations of unitary synaptic potentials help time a behavioral sequence. (1978) (14)
- Is regulation of a chloride channel in lymphocytes affected in cystic fibrosis? (1989) (13)
- Rescue of the protein folding defect in cystic fibrosis in vitro by the investigational small molecule, VX-809 (2010) (13)
- Crayfish escape behavior (2004) (13)
- Short Communications: Postsynaptic Inhibition of Crayfish Tonic Flexor Motor Neurones by Escape Commands (1980) (13)
- Acid in the airways. Focus on "Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis". (2006) (13)
- Basic aspects of cystic fibrosis (1991) (12)
- THE TELSON FLEXOR NEUROMUSCULAR SYSTEM OF THE CRAYFISH II. SEGMENT-SPECIFIC DIFFERENCES IN CONNECTIVITY BETWEEN PREMOTOR NEURONES AND THE MOTOR GIANTS (1987) (12)
- Maxillary sinusitis as a surrogate model for CF gene therapy clinical trials in patients with antrostomies. (1999) (11)
- Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance. (2016) (11)
- No CFTR: are CF symptoms milder? (1992) (11)
- Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel (2016) (10)
- Rules of conduct for the cystic fibrosis anion channel (2003) (10)
- Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus (2021) (10)
- THE TELSON FLEXOR NEUROMUSCULAR SYSTEM OF THE CRAYFISH III. THE ROLE OF FEEDFORWARD INHIBITION IN SHAPING A STEREOTYPED BEHAVIOUR PATTERN (1987) (10)
- A sensitive defense: Salt and cystic fibrosis (1997) (10)
- β-Adrenergic Sweat Responses in Cystic Fibrosis Heterozygotes with and without the ΔF508 Allele (1991) (9)
- Basic aspects of cystic fibrosis. (1990) (9)
- Lateral inhibition mediated by a non-spiking interneuron: circuit properties and consequences for behavior. (1982) (9)
- Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease (2017) (9)
- Cystic Fibrosis Transmembrane Conductance Regulator Gating Requires Cytosolic Electrolytes* (2001) (9)
- Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus. (2021) (9)
- Genomic DNA sequence of Rhesus (M. mulatta) cystic fibrosis (CFTR) gene (1998) (8)
- Invertebrate synapse: long-term maintenance of postsynaptic morphology following denervation. (1973) (8)
- Swelling and Ca2+-activated Anion Conductances in C127 Epithelial Cells Expressing WT and ΔF508-CFTR (1996) (8)
- Indictment of pore behaviour (1993) (8)
- The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements (2017) (8)
- Inhibition of airway surface fluid absorption by cholinergic stimulation (2016) (7)
- Ivacaftor restores CFTR-dependent sweat gland fluid secretion in cystic fibrosis subjects with S945L alleles. (2017) (6)
- Chloride channels in cystic fibrosis patients. (1990) (6)
- Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults (2018) (6)
- Secretion Rates of Human Nasal Submucosal Glands from Patients with Chronic Rhinosinusitis or Cystic Fibrosis (2015) (6)
- Natural animal models of human genetic diseases. (2002) (6)
- Feedforward afferent excitation of peripheral inhibitors in the crayfish escape system. (1987) (5)
- Amine and Peptide Modulation of a Voltage-Sensitive, Plasma Membrane Ca2+-Channel in Crayfish Skeletal Muscle (1990) (5)
- Local inhibitor of the crayfish telson-flexor motor giant neurons: morphology and physiology (2004) (5)
- Science under Scrutiny (1990) (5)
- Ion channels and transmembrane transporters (1993) (5)
- Plasticity of non‐giant flexion circuitry in chronically cut abdominal nerve cords of the crayfish, Procambarus clarkii. (1984) (4)
- The inexhaustible mouse nose. Focus on "olfactory epithelia exhibit progressive functional and morphological defects in CF mice". (2007) (4)
- Screening methods for cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in non-human primates (2000) (4)
- beta-adrenergic sweat responses in cystic fibrosis heterozygotes with and without the delta F508 allele. (1991) (4)
- Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia (2019) (4)
- Novel cystic fibrosis mutation L1093P: Functional analysis and possible Native American origin (2000) (4)
- ATP and chloride conductance (1992) (4)
- How to live a long and healthy life with cystic fibrosis: Lessons from the CF ferret. (2019) (3)
- Screening methods for cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in non-human primates (2000) (3)
- Measuring mucociliary transport and mucus properties in multiple regions of airway epithelial surfaces helps clarify cystic fibrosis defects. (2014) (3)
- A local interneurone which receives differential input from the medial and lateral giant axons. (1987) (2)
- How the sweat gland reveals levels of CFTR activity. (2022) (2)
- The mutant protein responds (1991) (2)
- Triggering and organizing functions of command neurons in crayfish escape behavior (1978) (1)
- A readily identifiable neuron. (1979) (1)
- Symposium Summaries (2015) (1)
- Improper ion balance resulting from defects in the ion channel CFTR underlies cystic fibrosis. Separate control mechanisms are now shown to regulate the flux of chloride and bicarbonate through this channel. (2003) (0)
- Time-lapse DIC studies of airway submucosal gland secretion (2006) (0)
- Screening methods for cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in non-human primates. (2000) (0)
- A Readily Identifiable Neuron: Neurobiology of the Mauthner Cell . Donald S. Faber and Henri Korn, Eds. Raven, New York, 1978. xii, 290 pp., illus. $25. (1979) (0)
- Mechanisms of Habituation Habituation: Perspectives from Child Development, Animal Behavior, and Neurophysiology Thomas J. Tighe Robert N. Leaton (1978) (0)
- Letting go of mucus (2014) (0)
- fluid from submucosal glands in early cystic fibrosis'' Focus on ''Hyperacidity of secreted Acid in the airways. (2016) (0)
- Amnesia and Memory Mechanisms. (1974) (0)
- Calcium-stimulated Cl- secretion in Calu-3 human airway cells requires CFTR. (1997) (0)
- Cystic fibrosis. The mutant protein responds. (1991) (0)
- Variation in CFTR-dependent ‘β-sweating’ among healthy adults (2022) (0)
- Cystic fibrosis. ATP and chloride conductance. (1992) (0)
- Twenty‐fifth Annual Meeting of Cystic Fibrosis Club and Clinical Symposia, San Jose, California, April 27–30, 1984 Session on Infection and Immunity (1985) (0)
- Cystic fibrosis. Indictment of pore behaviour. (1993) (0)
- Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model (2021) (0)
- Clinical protocol: AAV‐CFTR for the treatment of chronic sinusitis in CF patients (1996) (0)
- Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults (2018) (0)
- Single Gland Studies of Esophageal Gland Secretion (2006) (0)
- Left ventricular mass in coronary artery disease without hypertension 363 TABLE I Synopsis of data from 64 patients with angina pectoris (0)
- 39 Inhibition of CFTR slows forskolin-stimulated mucociliary clearance in ferret trachea (2015) (0)
- 14 Standardized protocol for ratiometric measurement of b-adrenergic/cholinergic sweating in human sweat glands (2015) (0)
- Cystic fibrosis: ion channels and transmembrane transporters. (1993) (0)
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